-- dump date 20140619_001552 -- class Genbank::misc_feature -- table misc_feature_note -- id note 471853000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 471853000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853000003 Walker A motif; other site 471853000004 ATP binding site [chemical binding]; other site 471853000005 Walker B motif; other site 471853000006 arginine finger; other site 471853000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 471853000008 DnaA box-binding interface [nucleotide binding]; other site 471853000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 471853000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 471853000011 putative DNA binding surface [nucleotide binding]; other site 471853000012 dimer interface [polypeptide binding]; other site 471853000013 beta-clamp/clamp loader binding surface; other site 471853000014 beta-clamp/translesion DNA polymerase binding surface; other site 471853000015 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471853000016 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 471853000017 recombination protein F; Reviewed; Region: recF; PRK00064 471853000018 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 471853000019 Walker A/P-loop; other site 471853000020 ATP binding site [chemical binding]; other site 471853000021 Q-loop/lid; other site 471853000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853000023 ABC transporter signature motif; other site 471853000024 Walker B; other site 471853000025 D-loop; other site 471853000026 H-loop/switch region; other site 471853000027 Protein of unknown function (DUF721); Region: DUF721; cl02324 471853000028 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 471853000029 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 471853000030 anchoring element; other site 471853000031 dimer interface [polypeptide binding]; other site 471853000032 ATP binding site [chemical binding]; other site 471853000033 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 471853000034 active site 471853000035 putative metal-binding site [ion binding]; other site 471853000036 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471853000037 DNA gyrase subunit A; Validated; Region: PRK05560 471853000038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471853000039 CAP-like domain; other site 471853000040 active site 471853000041 primary dimer interface [polypeptide binding]; other site 471853000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 471853000049 YCII-related domain; Region: YCII; cl00999 471853000050 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853000051 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853000052 active site 471853000053 metal binding site [ion binding]; metal-binding site 471853000054 Cupin domain; Region: Cupin_2; cl17218 471853000055 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000056 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000057 DNA binding site [nucleotide binding] 471853000058 domain linker motif; other site 471853000059 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000060 dimerization interface [polypeptide binding]; other site 471853000061 ligand binding site [chemical binding]; other site 471853000062 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000063 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853000064 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853000065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000066 putative PBP binding loops; other site 471853000067 dimer interface [polypeptide binding]; other site 471853000068 ABC-ATPase subunit interface; other site 471853000069 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000071 dimer interface [polypeptide binding]; other site 471853000072 conserved gate region; other site 471853000073 putative PBP binding loops; other site 471853000074 ABC-ATPase subunit interface; other site 471853000075 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471853000076 active site 471853000077 B-Box-type zinc finger; zinc binding domain (CHC3H2); often present in combination with other motifs, like RING zinc finger, NHL motif, coiled-coil or RFP domain in functionally unrelated proteins, most likely mediating protein-protein interaction; Region: BBOX; cl00034 471853000078 Zn2+ binding site [ion binding]; other site 471853000079 Rhomboid family; Region: Rhomboid; pfam01694 471853000080 Uncharacterized protein family (UPF0233); Region: UPF0233; pfam06781 471853000081 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471853000082 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 471853000083 active site 471853000084 catalytic site [active] 471853000085 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 471853000086 Glutamine amidotransferase class-I; Region: GATase; pfam00117 471853000087 glutamine binding [chemical binding]; other site 471853000088 catalytic triad [active] 471853000089 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853000090 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471853000091 active site 471853000092 ATP binding site [chemical binding]; other site 471853000093 substrate binding site [chemical binding]; other site 471853000094 activation loop (A-loop); other site 471853000095 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853000096 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853000097 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853000098 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853000099 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471853000100 active site 471853000101 ATP binding site [chemical binding]; other site 471853000102 substrate binding site [chemical binding]; other site 471853000103 activation loop (A-loop); other site 471853000104 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471853000105 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471853000106 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 471853000107 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471853000108 active site 471853000109 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471853000110 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471853000111 phosphopeptide binding site; other site 471853000112 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 471853000113 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471853000114 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471853000115 phosphopeptide binding site; other site 471853000116 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853000117 salt bridge; other site 471853000118 non-specific DNA binding site [nucleotide binding]; other site 471853000119 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471853000120 sequence-specific DNA binding site [nucleotide binding]; other site 471853000121 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 471853000122 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 471853000123 active site 471853000124 catalytic site [active] 471853000125 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 471853000126 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000127 ligand binding site [chemical binding]; other site 471853000128 dimerization interface [polypeptide binding]; other site 471853000129 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 471853000130 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853000131 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471853000132 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853000133 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853000134 substrate binding site [chemical binding]; other site 471853000135 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853000136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000137 dimer interface [polypeptide binding]; other site 471853000138 conserved gate region; other site 471853000139 putative PBP binding loops; other site 471853000140 ABC-ATPase subunit interface; other site 471853000141 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853000142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000143 dimer interface [polypeptide binding]; other site 471853000144 conserved gate region; other site 471853000145 putative PBP binding loops; other site 471853000146 ABC-ATPase subunit interface; other site 471853000147 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471853000148 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853000149 Walker A/P-loop; other site 471853000150 ATP binding site [chemical binding]; other site 471853000151 Q-loop/lid; other site 471853000152 ABC transporter signature motif; other site 471853000153 Walker B; other site 471853000154 D-loop; other site 471853000155 H-loop/switch region; other site 471853000156 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853000157 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471853000158 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853000159 Walker A/P-loop; other site 471853000160 ATP binding site [chemical binding]; other site 471853000161 Q-loop/lid; other site 471853000162 ABC transporter signature motif; other site 471853000163 Walker B; other site 471853000164 D-loop; other site 471853000165 H-loop/switch region; other site 471853000166 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853000167 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853000168 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471853000169 non-specific DNA interactions [nucleotide binding]; other site 471853000170 DNA binding site [nucleotide binding] 471853000171 sequence specific DNA binding site [nucleotide binding]; other site 471853000172 putative cAMP binding site [chemical binding]; other site 471853000173 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853000174 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853000175 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471853000176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853000177 DNA-binding site [nucleotide binding]; DNA binding site 471853000178 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853000179 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853000180 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853000181 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853000182 active site 471853000183 catalytic tetrad [active] 471853000184 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 471853000185 FMN binding site [chemical binding]; other site 471853000186 dimer interface [polypeptide binding]; other site 471853000187 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853000188 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853000189 Coenzyme A binding pocket [chemical binding]; other site 471853000190 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 471853000191 dimer interface [polypeptide binding]; other site 471853000192 catalytic triad [active] 471853000193 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 471853000194 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 471853000195 Protein of unknown function (DUF4232); Region: DUF4232; pfam14016 471853000196 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 471853000197 alpha-galactosidase; Region: PLN02808; cl17638 471853000198 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 471853000199 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000200 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000201 DNA binding site [nucleotide binding] 471853000202 domain linker motif; other site 471853000203 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000204 dimerization interface [polypeptide binding]; other site 471853000205 ligand binding site [chemical binding]; other site 471853000206 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000207 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000208 DNA binding site [nucleotide binding] 471853000209 domain linker motif; other site 471853000210 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000211 ligand binding site [chemical binding]; other site 471853000212 dimerization interface [polypeptide binding]; other site 471853000213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471853000214 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471853000215 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000216 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853000217 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000218 dimer interface [polypeptide binding]; other site 471853000219 conserved gate region; other site 471853000220 putative PBP binding loops; other site 471853000221 ABC-ATPase subunit interface; other site 471853000222 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853000224 Protein of unknown function, DUF624; Region: DUF624; pfam04854 471853000225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471853000226 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471853000227 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853000228 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 471853000229 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471853000230 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853000231 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471853000232 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471853000233 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471853000234 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471853000235 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471853000236 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 471853000237 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853000238 active site 471853000239 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853000240 FAD binding domain; Region: FAD_binding_4; pfam01565 471853000241 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853000242 Berberine and berberine like; Region: BBE; pfam08031 471853000243 Cupin; Region: Cupin_6; pfam12852 471853000244 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853000245 RibD C-terminal domain; Region: RibD_C; cl17279 471853000246 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471853000247 YCII-related domain; Region: YCII; cl00999 471853000248 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853000249 catalytic core [active] 471853000250 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 471853000251 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471853000252 Phosphotransferase enzyme family; Region: APH; pfam01636 471853000253 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471853000254 active site 471853000255 substrate binding site [chemical binding]; other site 471853000256 ATP binding site [chemical binding]; other site 471853000257 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775 471853000258 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 471853000259 dimerization interface [polypeptide binding]; other site 471853000260 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000261 DNA binding residues [nucleotide binding] 471853000262 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853000263 active site 471853000264 catalytic residues [active] 471853000265 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 471853000266 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 471853000267 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471853000268 helix-hairpin-helix signature motif; other site 471853000269 active site 471853000270 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853000271 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471853000272 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853000273 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 471853000274 Uncharacterized conserved protein [Function unknown]; Region: COG2353 471853000275 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853000276 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853000277 active site 471853000278 catalytic tetrad [active] 471853000279 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 471853000280 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471853000281 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853000282 catalytic residue [active] 471853000283 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853000284 homotrimer interaction site [polypeptide binding]; other site 471853000285 putative active site [active] 471853000286 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471853000287 catalytic residues [active] 471853000288 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 471853000289 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 471853000290 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 471853000291 Class I ribonucleotide reductase; Region: RNR_I; cd01679 471853000292 active site 471853000293 dimer interface [polypeptide binding]; other site 471853000294 catalytic residues [active] 471853000295 effector binding site; other site 471853000296 R2 peptide binding site; other site 471853000297 GIY-YIG domain of uncharacterized hypothetical protein found in phycodnavirus PBCV-1 DNA virus, T. thermophila Tlr element eoncoding protein Tlr8p, and similar proteins found in bacteria; Region: GIY-YIG_HE_Tlr8p_PBC-V_like; cd10443 471853000298 GIY-YIG motif/motif A; other site 471853000299 putative active site [active] 471853000300 putative metal binding site [ion binding]; other site 471853000301 GIYX(10-11)YIG family of class I homing endonucleases C-terminus (GIY-YIG_Cterm). Homing endonucleases promote the mobility of intron or intein by recognizing and cleaving a homologous allele that lacks the sequence. They catalyze a double-strand break...; Region: GIY-YIG_Cterm; cl11508 471853000302 DNA binding site [nucleotide binding] 471853000303 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 471853000304 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 471853000305 dimer interface [polypeptide binding]; other site 471853000306 putative radical transfer pathway; other site 471853000307 diiron center [ion binding]; other site 471853000308 tyrosyl radical; other site 471853000309 Predicted membrane protein [Function unknown]; Region: COG3462 471853000310 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000311 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000312 active site 471853000313 phosphorylation site [posttranslational modification] 471853000314 intermolecular recognition site; other site 471853000315 dimerization interface [polypeptide binding]; other site 471853000316 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000317 DNA binding residues [nucleotide binding] 471853000318 dimerization interface [polypeptide binding]; other site 471853000319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853000320 Histidine kinase; Region: HisKA_3; pfam07730 471853000321 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853000322 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471853000323 active site 471853000324 substrate binding site [chemical binding]; other site 471853000325 ATP binding site [chemical binding]; other site 471853000326 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853000327 probable F420-dependent oxidoreductase, Rv3520c family; Region: F420_Rv3520c; TIGR03559 471853000328 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853000329 DNA-binding site [nucleotide binding]; DNA binding site 471853000330 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471853000331 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853000332 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 471853000333 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 471853000334 active site 471853000335 Phosphotransferase enzyme family; Region: APH; pfam01636 471853000336 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471853000337 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853000338 FAD binding pocket [chemical binding]; other site 471853000339 FAD binding motif [chemical binding]; other site 471853000340 phosphate binding motif [ion binding]; other site 471853000341 NAD binding pocket [chemical binding]; other site 471853000342 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 471853000343 Catalytic NodB homology domain of Clostridium thermocellum acetylxylan esterase and its bacterial homologs; Region: CE4_CtAXE_like; cd10954 471853000344 NodB motif; other site 471853000345 active site 471853000346 catalytic site [active] 471853000347 Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309 471853000348 Amidohydrolase; Region: Amidohydro_4; pfam13147 471853000349 active site 471853000350 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471853000351 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471853000352 active site 471853000353 Transcription factor zinc-finger; Region: zf-TFIIB; pfam13453 471853000354 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853000355 putative dimer interface [polypeptide binding]; other site 471853000356 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853000357 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853000358 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853000359 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853000360 active site 471853000361 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471853000362 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853000363 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853000364 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853000365 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000366 NAD(P) binding site [chemical binding]; other site 471853000367 active site 471853000368 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853000369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853000370 DNA-binding site [nucleotide binding]; DNA binding site 471853000371 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 471853000372 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853000373 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853000374 active site pocket [active] 471853000375 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471853000376 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853000377 classical (c) SDRs; Region: SDR_c; cd05233 471853000378 NAD(P) binding site [chemical binding]; other site 471853000379 active site 471853000380 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853000381 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853000382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000383 dimer interface [polypeptide binding]; other site 471853000384 conserved gate region; other site 471853000385 putative PBP binding loops; other site 471853000386 ABC-ATPase subunit interface; other site 471853000387 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000389 dimer interface [polypeptide binding]; other site 471853000390 conserved gate region; other site 471853000391 putative PBP binding loops; other site 471853000392 ABC-ATPase subunit interface; other site 471853000393 Melibiase; Region: Melibiase; pfam02065 471853000394 Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism / Amino acid transport and metabolism]; Region: PrsA; COG0462 471853000395 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471853000396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853000397 active site 471853000398 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 471853000399 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 471853000400 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 471853000401 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 471853000402 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 471853000403 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853000404 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853000405 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471853000406 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471853000407 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853000408 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853000409 Zn-finger in ubiquitin-hydrolases and other protein; Region: zf-UBP; pfam02148 471853000410 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 471853000411 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 471853000412 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471853000413 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471853000414 Walker A/P-loop; other site 471853000415 ATP binding site [chemical binding]; other site 471853000416 Q-loop/lid; other site 471853000417 ABC transporter signature motif; other site 471853000418 Walker B; other site 471853000419 D-loop; other site 471853000420 H-loop/switch region; other site 471853000421 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 471853000422 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471853000423 ABC-ATPase subunit interface; other site 471853000424 dimer interface [polypeptide binding]; other site 471853000425 putative PBP binding regions; other site 471853000426 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471853000427 FecCD transport family; Region: FecCD; pfam01032 471853000428 ABC-ATPase subunit interface; other site 471853000429 dimer interface [polypeptide binding]; other site 471853000430 putative PBP binding regions; other site 471853000431 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 471853000432 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471853000433 intersubunit interface [polypeptide binding]; other site 471853000434 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000436 dimer interface [polypeptide binding]; other site 471853000437 conserved gate region; other site 471853000438 putative PBP binding loops; other site 471853000439 ABC-ATPase subunit interface; other site 471853000440 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000441 dimer interface [polypeptide binding]; other site 471853000442 conserved gate region; other site 471853000443 putative PBP binding loops; other site 471853000444 ABC-ATPase subunit interface; other site 471853000445 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853000446 active site 471853000447 active site 471853000448 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 471853000449 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853000450 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853000451 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853000452 putative active site [active] 471853000453 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853000454 HTH domain; Region: HTH_11; pfam08279 471853000455 WYL domain; Region: WYL; pfam13280 471853000456 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471853000457 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853000458 Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893 471853000459 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471853000460 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 471853000461 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853000462 TIGR04076 family protein; Region: TIGR04076 471853000463 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 471853000464 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853000465 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 471853000466 active site 471853000467 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471853000468 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853000469 Walker A/P-loop; other site 471853000470 ATP binding site [chemical binding]; other site 471853000471 Q-loop/lid; other site 471853000472 ABC transporter signature motif; other site 471853000473 Walker B; other site 471853000474 D-loop; other site 471853000475 H-loop/switch region; other site 471853000476 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853000477 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471853000478 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853000479 Walker A/P-loop; other site 471853000480 ATP binding site [chemical binding]; other site 471853000481 Q-loop/lid; other site 471853000482 ABC transporter signature motif; other site 471853000483 Walker B; other site 471853000484 D-loop; other site 471853000485 H-loop/switch region; other site 471853000486 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853000487 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471853000488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000489 dimer interface [polypeptide binding]; other site 471853000490 conserved gate region; other site 471853000491 ABC-ATPase subunit interface; other site 471853000492 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853000493 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000494 dimer interface [polypeptide binding]; other site 471853000495 conserved gate region; other site 471853000496 putative PBP binding loops; other site 471853000497 ABC-ATPase subunit interface; other site 471853000498 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 471853000499 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853000500 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 471853000501 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853000502 non-specific DNA binding site [nucleotide binding]; other site 471853000503 salt bridge; other site 471853000504 sequence-specific DNA binding site [nucleotide binding]; other site 471853000505 Cupin domain; Region: Cupin_2; pfam07883 471853000506 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853000507 active site 471853000508 metal binding site [ion binding]; metal-binding site 471853000509 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853000510 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853000511 active site 471853000512 catalytic tetrad [active] 471853000513 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 471853000514 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471853000515 active site 471853000516 catalytic triad [active] 471853000517 oxyanion hole [active] 471853000518 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 471853000519 substrate binding site [chemical binding]; other site 471853000520 catalytic residues [active] 471853000521 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 471853000522 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853000523 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853000524 Sulfatase; Region: Sulfatase; cl17466 471853000525 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853000526 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000527 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853000528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000529 dimer interface [polypeptide binding]; other site 471853000530 conserved gate region; other site 471853000531 ABC-ATPase subunit interface; other site 471853000532 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000533 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000534 dimer interface [polypeptide binding]; other site 471853000535 conserved gate region; other site 471853000536 putative PBP binding loops; other site 471853000537 ABC-ATPase subunit interface; other site 471853000538 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853000539 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 471853000540 Protein of unknown function (DUF3995); Region: DUF3995; pfam13160 471853000541 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 471853000542 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 471853000543 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853000544 FAD binding domain; Region: FAD_binding_4; pfam01565 471853000545 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471853000546 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471853000547 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 471853000548 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853000549 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853000550 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000552 dimer interface [polypeptide binding]; other site 471853000553 conserved gate region; other site 471853000554 putative PBP binding loops; other site 471853000555 ABC-ATPase subunit interface; other site 471853000556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853000557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000558 dimer interface [polypeptide binding]; other site 471853000559 putative PBP binding loops; other site 471853000560 ABC-ATPase subunit interface; other site 471853000561 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000562 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853000563 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000564 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000565 DNA binding site [nucleotide binding] 471853000566 domain linker motif; other site 471853000567 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853000568 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853000569 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853000570 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 471853000571 Dehydratase family; Region: ILVD_EDD; cl00340 471853000572 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 471853000573 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853000574 NAD(P) binding site [chemical binding]; other site 471853000575 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 471853000576 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 471853000577 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471853000578 Protein of unknown function (DUF998); Region: DUF998; pfam06197 471853000579 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853000580 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471853000581 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853000582 Predicted transcriptional regulators [Transcription]; Region: COG1733 471853000583 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471853000584 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471853000585 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471853000586 TAP-like protein; Region: Abhydrolase_4; pfam08386 471853000587 RibD C-terminal domain; Region: RibD_C; cl17279 471853000588 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471853000589 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471853000590 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471853000591 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853000592 HTH domain; Region: HTH_11; pfam08279 471853000593 WYL domain; Region: WYL; pfam13280 471853000594 RibD C-terminal domain; Region: RibD_C; cl17279 471853000595 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 471853000596 intersubunit interface [polypeptide binding]; other site 471853000597 active site 471853000598 catalytic residue [active] 471853000599 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 471853000600 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853000601 NAD(P) binding site [chemical binding]; other site 471853000602 catalytic residues [active] 471853000603 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853000604 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 471853000605 SprT-like family; Region: SprT-like; pfam10263 471853000606 SprT homologues; Region: SprT; cl01182 471853000607 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853000608 active site 471853000609 catalytic residues [active] 471853000610 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853000611 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853000612 DNA binding residues [nucleotide binding] 471853000613 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 471853000614 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853000615 S-adenosylmethionine binding site [chemical binding]; other site 471853000616 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 471853000617 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 471853000618 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 471853000619 TAP-like protein; Region: Abhydrolase_4; pfam08386 471853000620 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471853000621 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471853000622 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853000623 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853000624 Coenzyme A binding pocket [chemical binding]; other site 471853000625 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853000626 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853000627 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471853000628 dimerization interface [polypeptide binding]; other site 471853000629 cyclase homology domain; Region: CHD; cd07302 471853000630 nucleotidyl binding site; other site 471853000631 metal binding site [ion binding]; metal-binding site 471853000632 dimer interface [polypeptide binding]; other site 471853000633 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 471853000634 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471853000635 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471853000636 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471853000637 ligand binding site [chemical binding]; other site 471853000638 flexible hinge region; other site 471853000639 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471853000640 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853000641 ATP binding site [chemical binding]; other site 471853000642 putative Mg++ binding site [ion binding]; other site 471853000643 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853000644 nucleotide binding region [chemical binding]; other site 471853000645 ATP-binding site [chemical binding]; other site 471853000646 Helicase associated domain (HA2); Region: HA2; pfam04408 471853000647 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 471853000648 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 471853000649 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 471853000650 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471853000651 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853000652 S-adenosylmethionine binding site [chemical binding]; other site 471853000653 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 471853000654 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853000655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853000656 putative substrate translocation pore; other site 471853000657 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000658 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000659 active site 471853000660 phosphorylation site [posttranslational modification] 471853000661 intermolecular recognition site; other site 471853000662 dimerization interface [polypeptide binding]; other site 471853000663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000664 DNA binding residues [nucleotide binding] 471853000665 dimerization interface [polypeptide binding]; other site 471853000666 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853000667 Coenzyme A binding pocket [chemical binding]; other site 471853000668 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 471853000669 FAD binding site [chemical binding]; other site 471853000670 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 471853000671 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 471853000672 THF binding site; other site 471853000673 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 471853000674 substrate binding site [chemical binding]; other site 471853000675 THF binding site; other site 471853000676 zinc-binding site [ion binding]; other site 471853000677 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 471853000678 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853000679 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471853000680 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471853000681 iron-sulfur cluster [ion binding]; other site 471853000682 [2Fe-2S] cluster binding site [ion binding]; other site 471853000683 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 471853000684 RNA polymerase sigma factor SigL; Provisional; Region: PRK09645 471853000685 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853000686 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853000687 DNA binding residues [nucleotide binding] 471853000688 Putative zinc-finger; Region: zf-HC2; pfam13490 471853000689 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853000690 Predicted nuclease (RecB family) [General function prediction only]; Region: COG2251 471853000691 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 471853000692 Part of AAA domain; Region: AAA_19; pfam13245 471853000693 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 471853000694 AAA domain; Region: AAA_12; pfam13087 471853000695 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853000696 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471853000697 AAA domain; Region: AAA_18; pfam13238 471853000698 active site 471853000699 amino acid transporter; Region: 2A0306; TIGR00909 471853000700 Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044 471853000701 diiron binding motif [ion binding]; other site 471853000702 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_2; cd02433 471853000703 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471853000704 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 471853000705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853000706 Walker A/P-loop; other site 471853000707 ATP binding site [chemical binding]; other site 471853000708 Q-loop/lid; other site 471853000709 ABC transporter signature motif; other site 471853000710 Walker B; other site 471853000711 D-loop; other site 471853000712 H-loop/switch region; other site 471853000713 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471853000714 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853000715 enterobactin exporter EntS; Provisional; Region: PRK10489 471853000716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853000717 putative substrate translocation pore; other site 471853000718 Cupin domain; Region: Cupin_2; pfam07883 471853000719 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853000720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853000721 NAD(P) binding site [chemical binding]; other site 471853000722 active site 471853000723 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471853000724 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853000725 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853000726 DNA binding residues [nucleotide binding] 471853000727 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 471853000728 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853000729 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853000730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853000731 Coenzyme A binding pocket [chemical binding]; other site 471853000732 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 471853000733 RibD C-terminal domain; Region: RibD_C; cl17279 471853000734 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471853000735 ATP-dependent DNA ligase; Reviewed; Region: ligB; PRK03180 471853000736 Adenylation domain of archaeal and bacterial LigB-like DNA ligases; Region: Adenylation_DNA_ligase_Arch_LigB; cd07901 471853000737 active site 471853000738 DNA binding site [nucleotide binding] 471853000739 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 471853000740 DNA binding site [nucleotide binding] 471853000741 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471853000742 hydrophobic ligand binding site; other site 471853000743 Permease family; Region: Xan_ur_permease; pfam00860 471853000744 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 471853000745 active site 471853000746 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000747 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853000748 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853000749 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000750 dimer interface [polypeptide binding]; other site 471853000751 putative PBP binding loops; other site 471853000752 ABC-ATPase subunit interface; other site 471853000753 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000754 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000755 dimer interface [polypeptide binding]; other site 471853000756 conserved gate region; other site 471853000757 putative PBP binding loops; other site 471853000758 ABC-ATPase subunit interface; other site 471853000759 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 471853000760 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853000761 substrate binding site [chemical binding]; other site 471853000762 dimer interface [polypeptide binding]; other site 471853000763 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853000764 ATP binding site [chemical binding]; other site 471853000765 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000766 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000767 DNA binding site [nucleotide binding] 471853000768 domain linker motif; other site 471853000769 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000770 ligand binding site [chemical binding]; other site 471853000771 dimerization interface [polypeptide binding]; other site 471853000772 Cupin domain; Region: Cupin_2; pfam07883 471853000773 Bacterial protein of unknown function (DUF899); Region: DUF899; pfam05988 471853000774 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853000775 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853000776 WHG domain; Region: WHG; pfam13305 471853000777 Uncharacterized conserved protein [Function unknown]; Region: COG2128 471853000778 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 471853000779 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471853000780 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853000781 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471853000782 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000784 active site 471853000785 phosphorylation site [posttranslational modification] 471853000786 intermolecular recognition site; other site 471853000787 dimerization interface [polypeptide binding]; other site 471853000788 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000789 DNA binding residues [nucleotide binding] 471853000790 dimerization interface [polypeptide binding]; other site 471853000791 Histidine kinase; Region: HisKA_3; pfam07730 471853000792 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471853000793 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471853000794 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853000795 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853000796 Walker A/P-loop; other site 471853000797 ATP binding site [chemical binding]; other site 471853000798 Q-loop/lid; other site 471853000799 ABC transporter signature motif; other site 471853000800 Walker B; other site 471853000801 D-loop; other site 471853000802 H-loop/switch region; other site 471853000803 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 471853000804 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471853000805 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 471853000806 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 471853000807 active site 471853000808 dimer interface [polypeptide binding]; other site 471853000809 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 471853000810 dimer interface [polypeptide binding]; other site 471853000811 active site 471853000812 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471853000813 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 471853000814 substrate binding pocket [chemical binding]; other site 471853000815 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471853000816 Histidine kinase; Region: HisKA_3; pfam07730 471853000817 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853000818 ATP binding site [chemical binding]; other site 471853000819 Mg2+ binding site [ion binding]; other site 471853000820 G-X-G motif; other site 471853000821 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000822 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000823 active site 471853000824 phosphorylation site [posttranslational modification] 471853000825 intermolecular recognition site; other site 471853000826 dimerization interface [polypeptide binding]; other site 471853000827 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000828 dimerization interface [polypeptide binding]; other site 471853000829 DNA binding residues [nucleotide binding] 471853000830 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471853000831 Short C-terminal domain; Region: SHOCT; pfam09851 471853000832 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471853000833 anti sigma factor interaction site; other site 471853000834 regulatory phosphorylation site [posttranslational modification]; other site 471853000835 active site 471853000836 metal binding site [ion binding]; metal-binding site 471853000837 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 471853000838 AsnC family; Region: AsnC_trans_reg; pfam01037 471853000839 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471853000840 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 471853000841 putative DNA binding site [nucleotide binding]; other site 471853000842 putative Zn2+ binding site [ion binding]; other site 471853000843 AsnC family; Region: AsnC_trans_reg; pfam01037 471853000844 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853000845 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853000846 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853000847 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 471853000848 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 471853000849 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 471853000850 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853000851 Sulfatase; Region: Sulfatase; cl17466 471853000852 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000853 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853000854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853000855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000856 conserved gate region; other site 471853000857 dimer interface [polypeptide binding]; other site 471853000858 putative PBP binding loops; other site 471853000859 ABC-ATPase subunit interface; other site 471853000860 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000862 dimer interface [polypeptide binding]; other site 471853000863 conserved gate region; other site 471853000864 putative PBP binding loops; other site 471853000865 ABC-ATPase subunit interface; other site 471853000866 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853000867 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853000868 DNA binding site [nucleotide binding] 471853000869 domain linker motif; other site 471853000870 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853000871 ligand binding site [chemical binding]; other site 471853000872 dimerization interface [polypeptide binding]; other site 471853000873 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000874 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853000875 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853000876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000877 dimer interface [polypeptide binding]; other site 471853000878 conserved gate region; other site 471853000879 putative PBP binding loops; other site 471853000880 ABC-ATPase subunit interface; other site 471853000881 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000882 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000883 dimer interface [polypeptide binding]; other site 471853000884 conserved gate region; other site 471853000885 putative PBP binding loops; other site 471853000886 ABC-ATPase subunit interface; other site 471853000887 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 471853000888 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 471853000889 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471853000890 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853000891 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853000892 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853000893 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853000894 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853000895 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853000896 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853000897 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853000898 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853000899 putative active site [active] 471853000900 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853000901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000902 dimer interface [polypeptide binding]; other site 471853000903 conserved gate region; other site 471853000904 putative PBP binding loops; other site 471853000905 ABC-ATPase subunit interface; other site 471853000906 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853000907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853000908 dimer interface [polypeptide binding]; other site 471853000909 conserved gate region; other site 471853000910 putative PBP binding loops; other site 471853000911 ABC-ATPase subunit interface; other site 471853000912 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853000913 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853000914 CGNR zinc finger; Region: zf-CGNR; pfam11706 471853000915 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 471853000916 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 471853000917 catalytic residues [active] 471853000918 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853000919 Phosphotransferase enzyme family; Region: APH; pfam01636 471853000920 active site 471853000921 substrate binding site [chemical binding]; other site 471853000922 ATP binding site [chemical binding]; other site 471853000923 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 471853000924 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 471853000925 tetramer interface [polypeptide binding]; other site 471853000926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853000927 catalytic residue [active] 471853000928 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 471853000929 GxGYxY sequence motif in domain of unknown function; Region: GxGYxYP; pfam14323 471853000930 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853000931 DinB superfamily; Region: DinB_2; pfam12867 471853000932 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 471853000933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853000934 S-adenosylmethionine binding site [chemical binding]; other site 471853000935 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471853000936 TIGR03086 family protein; Region: TIGR03086 471853000937 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853000938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000939 active site 471853000940 phosphorylation site [posttranslational modification] 471853000941 intermolecular recognition site; other site 471853000942 dimerization interface [polypeptide binding]; other site 471853000943 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853000944 DNA binding residues [nucleotide binding] 471853000945 dimerization interface [polypeptide binding]; other site 471853000946 Histidine kinase; Region: HisKA_3; pfam07730 471853000947 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853000948 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853000949 Response regulator receiver domain; Region: Response_reg; pfam00072 471853000950 active site 471853000951 phosphorylation site [posttranslational modification] 471853000952 intermolecular recognition site; other site 471853000953 dimerization interface [polypeptide binding]; other site 471853000954 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471853000955 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471853000956 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853000957 dimer interface [polypeptide binding]; other site 471853000958 phosphorylation site [posttranslational modification] 471853000959 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853000960 ATP binding site [chemical binding]; other site 471853000961 Mg2+ binding site [ion binding]; other site 471853000962 G-X-G motif; other site 471853000963 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471853000964 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 471853000965 DXD motif; other site 471853000966 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471853000967 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 471853000968 putative hydrophobic ligand binding site [chemical binding]; other site 471853000969 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853000970 putative DNA binding site [nucleotide binding]; other site 471853000971 putative Zn2+ binding site [ion binding]; other site 471853000972 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 471853000973 glutamate dehydrogenase; Provisional; Region: PRK09414 471853000974 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471853000975 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 471853000976 NAD(P) binding pocket [chemical binding]; other site 471853000977 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853000978 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853000979 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853000980 active site 471853000981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853000982 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853000983 Coenzyme A binding pocket [chemical binding]; other site 471853000984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853000985 putative Zn2+ binding site [ion binding]; other site 471853000986 putative DNA binding site [nucleotide binding]; other site 471853000987 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; some contain an N-terminal GntR family winged HTH DNA-binding domain; Region: SRPBCC_CalC_Aha1-like_GntR-HTH; cd08893 471853000988 putative hydrophobic ligand binding site [chemical binding]; other site 471853000989 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853000990 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471853000991 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853000992 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 471853000993 Walker A/P-loop; other site 471853000994 ATP binding site [chemical binding]; other site 471853000995 Q-loop/lid; other site 471853000996 ABC transporter signature motif; other site 471853000997 Walker B; other site 471853000998 D-loop; other site 471853000999 H-loop/switch region; other site 471853001000 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 471853001001 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001002 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853001003 DNA binding residues [nucleotide binding] 471853001004 dimerization interface [polypeptide binding]; other site 471853001005 Lamin Tail Domain; Region: LTD; pfam00932 471853001006 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 471853001007 generic binding surface I; other site 471853001008 generic binding surface II; other site 471853001009 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 471853001010 putative active site [active] 471853001011 putative catalytic site [active] 471853001012 putative Mg binding site IVb [ion binding]; other site 471853001013 putative phosphate binding site [ion binding]; other site 471853001014 putative DNA binding site [nucleotide binding]; other site 471853001015 putative Mg binding site IVa [ion binding]; other site 471853001016 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 471853001017 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853001018 active site 471853001019 metal binding site [ion binding]; metal-binding site 471853001020 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 471853001021 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 471853001022 ATP-binding site [chemical binding]; other site 471853001023 Gluconate-6-phosphate binding site [chemical binding]; other site 471853001024 Shikimate kinase; Region: SKI; pfam01202 471853001025 pyruvate dehydrogenase; Provisional; Region: PRK06546 471853001026 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 471853001027 PYR/PP interface [polypeptide binding]; other site 471853001028 dimer interface [polypeptide binding]; other site 471853001029 tetramer interface [polypeptide binding]; other site 471853001030 TPP binding site [chemical binding]; other site 471853001031 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471853001032 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 471853001033 TPP-binding site [chemical binding]; other site 471853001034 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471853001035 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471853001036 catalytic residues [active] 471853001037 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471853001038 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 471853001039 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 471853001040 putative active site [active] 471853001041 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001042 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853001043 putative substrate translocation pore; other site 471853001044 phosphoglucomutase; Validated; Region: PRK07564 471853001045 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 471853001046 active site 471853001047 substrate binding site [chemical binding]; other site 471853001048 metal binding site [ion binding]; metal-binding site 471853001049 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853001050 active site 471853001051 prephenate dehydratase; Provisional; Region: PRK11898 471853001052 Prephenate dehydratase; Region: PDT; pfam00800 471853001053 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 471853001054 putative L-Phe binding site [chemical binding]; other site 471853001055 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471853001056 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 471853001057 seryl-tRNA synthetase; Provisional; Region: PRK05431 471853001058 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 471853001059 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 471853001060 dimer interface [polypeptide binding]; other site 471853001061 active site 471853001062 motif 1; other site 471853001063 motif 2; other site 471853001064 motif 3; other site 471853001065 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 471853001066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853001067 active site 471853001068 motif I; other site 471853001069 motif II; other site 471853001070 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 471853001071 TPR repeat; Region: TPR_11; pfam13414 471853001072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853001073 binding surface 471853001074 TPR motif; other site 471853001075 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853001076 YCII-related domain; Region: YCII; cl00999 471853001077 Protein of unknown function (DUF2587); Region: DUF2587; pfam10759 471853001078 cyclase homology domain; Region: CHD; cd07302 471853001079 nucleotidyl binding site; other site 471853001080 metal binding site [ion binding]; metal-binding site 471853001081 dimer interface [polypeptide binding]; other site 471853001082 AAA ATPase domain; Region: AAA_16; pfam13191 471853001083 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853001084 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853001085 binding surface 471853001086 TPR motif; other site 471853001087 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853001088 dimerization interface [polypeptide binding]; other site 471853001089 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 471853001090 putative active cleft [active] 471853001091 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471853001092 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471853001093 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853001094 Sulfatase; Region: Sulfatase; pfam00884 471853001095 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 471853001096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853001097 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853001098 Walker A/P-loop; other site 471853001099 ATP binding site [chemical binding]; other site 471853001100 Q-loop/lid; other site 471853001101 ABC transporter signature motif; other site 471853001102 Walker B; other site 471853001103 D-loop; other site 471853001104 H-loop/switch region; other site 471853001105 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471853001106 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471853001107 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471853001108 AAA ATPase domain; Region: AAA_16; pfam13191 471853001109 Predicted ATPase [General function prediction only]; Region: COG3903 471853001110 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853001111 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471853001112 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853001113 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853001114 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001115 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471853001116 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 471853001117 NAD(P) binding site [chemical binding]; other site 471853001118 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853001119 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001120 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853001121 active site 471853001122 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001123 putative substrate translocation pore; other site 471853001124 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471853001125 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 471853001126 active site 471853001127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001128 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 471853001129 NAD(P) binding site [chemical binding]; other site 471853001130 active site 471853001131 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853001132 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853001133 active site 471853001134 phosphorylation site [posttranslational modification] 471853001135 intermolecular recognition site; other site 471853001136 dimerization interface [polypeptide binding]; other site 471853001137 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001138 DNA binding residues [nucleotide binding] 471853001139 dimerization interface [polypeptide binding]; other site 471853001140 Histidine kinase; Region: HisKA_3; pfam07730 471853001141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853001142 Mg2+ binding site [ion binding]; other site 471853001143 G-X-G motif; other site 471853001144 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471853001145 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853001146 DNA-binding site [nucleotide binding]; DNA binding site 471853001147 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853001148 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853001149 homodimer interface [polypeptide binding]; other site 471853001150 catalytic residue [active] 471853001151 DoxX-like family; Region: DoxX_2; pfam13564 471853001152 hypothetical protein; Provisional; Region: PRK06184 471853001153 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471853001154 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001155 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853001156 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471853001157 SnoaL-like domain; Region: SnoaL_2; pfam12680 471853001158 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 471853001159 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 471853001160 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 471853001161 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 471853001162 Walker A/P-loop; other site 471853001163 ATP binding site [chemical binding]; other site 471853001164 Q-loop/lid; other site 471853001165 ABC transporter signature motif; other site 471853001166 Walker B; other site 471853001167 D-loop; other site 471853001168 H-loop/switch region; other site 471853001169 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 471853001170 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 471853001171 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 471853001172 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 471853001173 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853001174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853001175 homodimer interface [polypeptide binding]; other site 471853001176 catalytic residue [active] 471853001177 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853001178 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853001179 active site 471853001180 catalytic tetrad [active] 471853001181 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853001182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 471853001183 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471853001184 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471853001185 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853001186 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853001187 CCC1-related family of proteins; Region: CCC1_like; cl00278 471853001188 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471853001189 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471853001190 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853001191 DNA-binding site [nucleotide binding]; DNA binding site 471853001192 UTRA domain; Region: UTRA; pfam07702 471853001193 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853001194 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001195 putative PBP binding loops; other site 471853001196 ABC-ATPase subunit interface; other site 471853001197 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853001198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001199 dimer interface [polypeptide binding]; other site 471853001200 conserved gate region; other site 471853001201 putative PBP binding loops; other site 471853001202 ABC-ATPase subunit interface; other site 471853001203 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 471853001204 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 471853001205 putative active site cavity [active] 471853001206 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853001207 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471853001208 Uncharacterized conserved protein [Function unknown]; Region: COG3189 471853001209 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471853001210 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853001211 Walker A/P-loop; other site 471853001212 ATP binding site [chemical binding]; other site 471853001213 Q-loop/lid; other site 471853001214 ABC transporter signature motif; other site 471853001215 Walker B; other site 471853001216 D-loop; other site 471853001217 H-loop/switch region; other site 471853001218 Domain of unknown function DUF87; Region: DUF87; pfam01935 471853001219 AAA-like domain; Region: AAA_10; pfam12846 471853001220 Zonular occludens toxin (Zot); Region: Zot; cl17485 471853001221 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853001222 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001223 DNA binding residues [nucleotide binding] 471853001224 dimerization interface [polypeptide binding]; other site 471853001225 Predicted ATPase [General function prediction only]; Region: COG3903 471853001226 Cupin domain; Region: Cupin_2; pfam07883 471853001227 RibD C-terminal domain; Region: RibD_C; cl17279 471853001228 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 471853001229 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 471853001230 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001231 Lipase maturation factor; Region: LMF1; pfam06762 471853001232 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471853001233 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471853001234 Walker A/P-loop; other site 471853001235 ATP binding site [chemical binding]; other site 471853001236 Q-loop/lid; other site 471853001237 ABC transporter signature motif; other site 471853001238 Walker B; other site 471853001239 D-loop; other site 471853001240 H-loop/switch region; other site 471853001241 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 471853001242 NMT1/THI5 like; Region: NMT1; pfam09084 471853001243 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471853001244 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853001245 Domain of unknown function DUF77; Region: DUF77; pfam01910 471853001246 aminoglycoside resistance protein; Provisional; Region: PRK13746 471853001247 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471853001248 active site 471853001249 NTP binding site [chemical binding]; other site 471853001250 metal binding triad [ion binding]; metal-binding site 471853001251 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 471853001252 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 471853001253 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471853001254 FtsX-like permease family; Region: FtsX; pfam02687 471853001255 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853001256 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471853001257 Walker A/P-loop; other site 471853001258 ATP binding site [chemical binding]; other site 471853001259 Q-loop/lid; other site 471853001260 ABC transporter signature motif; other site 471853001261 Walker B; other site 471853001262 D-loop; other site 471853001263 H-loop/switch region; other site 471853001264 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 471853001265 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853001266 WYL domain; Region: WYL; pfam13280 471853001267 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 471853001268 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 471853001269 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853001270 MarR family; Region: MarR; pfam01047 471853001271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 471853001272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001273 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471853001274 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471853001275 Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561 471853001276 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 471853001277 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853001278 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853001279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001280 dimer interface [polypeptide binding]; other site 471853001281 conserved gate region; other site 471853001282 putative PBP binding loops; other site 471853001283 ABC-ATPase subunit interface; other site 471853001284 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853001285 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853001286 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853001287 Walker A/P-loop; other site 471853001288 ATP binding site [chemical binding]; other site 471853001289 Q-loop/lid; other site 471853001290 ABC transporter signature motif; other site 471853001291 Walker B; other site 471853001292 D-loop; other site 471853001293 H-loop/switch region; other site 471853001294 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853001295 Walker A/P-loop; other site 471853001296 ATP binding site [chemical binding]; other site 471853001297 Q-loop/lid; other site 471853001298 ABC transporter signature motif; other site 471853001299 Walker B; other site 471853001300 D-loop; other site 471853001301 H-loop/switch region; other site 471853001302 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853001303 Glycosyl hydrolase family 43; Region: GH43_ABN_2; cd08999 471853001304 putative substrate binding site [chemical binding]; other site 471853001305 active site 471853001306 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 471853001307 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853001308 putative metal binding site [ion binding]; other site 471853001309 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853001310 active site 471853001311 metal binding site [ion binding]; metal-binding site 471853001312 translocation protein TolB; Provisional; Region: tolB; PRK02889 471853001313 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 471853001314 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853001315 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853001316 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853001317 Domain of unknown function (DUF1876); Region: DUF1876; pfam08962 471853001318 ATP-dependent DNA ligase; Reviewed; Region: ligC; PRK08224 471853001319 Adenylation domain of Mycobacterium tuberculosis LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigC; cd07905 471853001320 active site 471853001321 DNA binding site [nucleotide binding] 471853001322 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigC is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigC; cd07970 471853001323 DNA binding site [nucleotide binding] 471853001324 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853001325 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853001326 Walker A/P-loop; other site 471853001327 ATP binding site [chemical binding]; other site 471853001328 Q-loop/lid; other site 471853001329 ABC transporter signature motif; other site 471853001330 Walker B; other site 471853001331 D-loop; other site 471853001332 H-loop/switch region; other site 471853001333 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471853001334 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853001335 Walker A/P-loop; other site 471853001336 ATP binding site [chemical binding]; other site 471853001337 Q-loop/lid; other site 471853001338 ABC transporter signature motif; other site 471853001339 Walker B; other site 471853001340 D-loop; other site 471853001341 H-loop/switch region; other site 471853001342 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853001343 DNA-binding site [nucleotide binding]; DNA binding site 471853001344 Protein of unknown function (DUF328); Region: DUF328; cl01143 471853001345 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471853001346 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001347 putative substrate translocation pore; other site 471853001348 LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865 471853001349 nucleotide binding site [chemical binding]; other site 471853001350 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853001351 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471853001352 Acylphosphatase; Region: Acylphosphatase; pfam00708 471853001353 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 471853001354 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 471853001355 CAAX protease self-immunity; Region: Abi; pfam02517 471853001356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853001358 putative substrate translocation pore; other site 471853001359 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471853001360 Helix-turn-helix domain; Region: HTH_38; pfam13936 471853001361 MarR family; Region: MarR; pfam01047 471853001362 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471853001363 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471853001364 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853001365 ATP binding site [chemical binding]; other site 471853001366 putative Mg++ binding site [ion binding]; other site 471853001367 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 471853001368 GIY-YIG motif/motif A; other site 471853001369 active site 471853001370 catalytic site [active] 471853001371 metal binding site [ion binding]; metal-binding site 471853001372 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 471853001373 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853001374 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471853001375 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853001376 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 471853001377 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471853001378 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471853001379 AAA domain; Region: AAA_14; pfam13173 471853001380 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 471853001381 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK07818 471853001382 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471853001383 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853001384 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853001385 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471853001386 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853001387 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853001388 catalytic residue [active] 471853001389 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 471853001390 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471853001391 active site residue [active] 471853001392 O-succinylhomoserine sulfhydrylase; Provisional; Region: PRK07810 471853001393 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853001394 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853001395 catalytic residue [active] 471853001396 hypothetical protein; Provisional; Region: PRK11770 471853001397 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471853001398 Domain of unknown function (DUF307); Region: DUF307; pfam03733 471853001399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853001400 active site 471853001401 Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324 471853001402 NADP binding site [chemical binding]; other site 471853001403 substrate binding site [chemical binding]; other site 471853001404 active site 471853001405 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853001406 Coenzyme A binding pocket [chemical binding]; other site 471853001407 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471853001408 nucleoside/Zn binding site; other site 471853001409 dimer interface [polypeptide binding]; other site 471853001410 catalytic motif [active] 471853001411 RNA polymerase factor sigma-70; Validated; Region: PRK08241 471853001412 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001413 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853001414 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 471853001415 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471853001416 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471853001417 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853001418 putative DNA binding site [nucleotide binding]; other site 471853001419 putative Zn2+ binding site [ion binding]; other site 471853001420 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471853001421 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 471853001422 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471853001423 Conserved hypothetical protein 698; Region: Cons_hypoth698; pfam03601 471853001424 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 471853001425 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471853001426 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 471853001427 putative dimerization interface [polypeptide binding]; other site 471853001428 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 471853001429 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 471853001430 NAD-dependent deacetylase; Provisional; Region: PRK05333 471853001431 SIRT4: Eukaryotic and prokaryotic group (class2) which includes human sirtuin SIRT4 and several bacterial homologs; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein...; Region: SIRT4; cd01409 471853001432 NAD+ binding site [chemical binding]; other site 471853001433 substrate binding site [chemical binding]; other site 471853001434 Zn binding site [ion binding]; other site 471853001435 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 471853001436 A new structural DNA glycosylase; Region: AlkD_like; cd06561 471853001437 active site 471853001438 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853001439 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 471853001440 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471853001441 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471853001442 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853001443 FAD binding pocket [chemical binding]; other site 471853001444 FAD binding motif [chemical binding]; other site 471853001445 phosphate binding motif [ion binding]; other site 471853001446 NAD binding pocket [chemical binding]; other site 471853001447 O-methyltransferase; Region: Methyltransf_2; pfam00891 471853001448 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 471853001449 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 471853001450 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 471853001451 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853001452 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853001453 Walker A/P-loop; other site 471853001454 ATP binding site [chemical binding]; other site 471853001455 Q-loop/lid; other site 471853001456 ABC transporter signature motif; other site 471853001457 Walker B; other site 471853001458 D-loop; other site 471853001459 H-loop/switch region; other site 471853001460 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471853001461 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853001462 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853001463 dimerization interface [polypeptide binding]; other site 471853001464 putative DNA binding site [nucleotide binding]; other site 471853001465 putative Zn2+ binding site [ion binding]; other site 471853001466 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 471853001467 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853001468 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853001469 motif II; other site 471853001470 RibD C-terminal domain; Region: RibD_C; cl17279 471853001471 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471853001472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853001473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853001474 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 471853001475 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471853001476 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like6; cd05664 471853001477 metal binding site [ion binding]; metal-binding site 471853001478 putative dimer interface [polypeptide binding]; other site 471853001479 Laminarinase, member of the glycosyl hydrolase family 16; Region: GH16_laminarinase_like; cd08023 471853001480 active site 471853001481 catalytic residues [active] 471853001482 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471853001483 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471853001484 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 471853001485 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853001486 Walker A/P-loop; other site 471853001487 ATP binding site [chemical binding]; other site 471853001488 Q-loop/lid; other site 471853001489 ABC transporter signature motif; other site 471853001490 Walker B; other site 471853001491 D-loop; other site 471853001492 H-loop/switch region; other site 471853001493 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 471853001494 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853001495 Walker A motif; other site 471853001496 ATP binding site [chemical binding]; other site 471853001497 Walker B motif; other site 471853001498 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 471853001499 recombination protein RecR; Reviewed; Region: recR; PRK00076 471853001500 RecR protein; Region: RecR; pfam02132 471853001501 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 471853001502 putative active site [active] 471853001503 putative metal-binding site [ion binding]; other site 471853001504 tetramer interface [polypeptide binding]; other site 471853001505 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853001506 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 471853001507 Walker A/P-loop; other site 471853001508 ATP binding site [chemical binding]; other site 471853001509 Q-loop/lid; other site 471853001510 ABC transporter signature motif; other site 471853001511 Walker B; other site 471853001512 D-loop; other site 471853001513 H-loop/switch region; other site 471853001514 hypothetical protein; Provisional; Region: PRK10621 471853001515 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 471853001516 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853001517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001518 dimer interface [polypeptide binding]; other site 471853001519 conserved gate region; other site 471853001520 putative PBP binding loops; other site 471853001521 ABC-ATPase subunit interface; other site 471853001522 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001523 dimer interface [polypeptide binding]; other site 471853001524 conserved gate region; other site 471853001525 putative PBP binding loops; other site 471853001526 ABC-ATPase subunit interface; other site 471853001527 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853001528 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853001529 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853001530 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853001531 active site 471853001532 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853001533 catalytic tetrad [active] 471853001534 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853001535 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853001536 DNA binding site [nucleotide binding] 471853001537 domain linker motif; other site 471853001538 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853001539 dimerization interface [polypeptide binding]; other site 471853001540 ligand binding site [chemical binding]; other site 471853001541 aspartate kinase; Reviewed; Region: PRK06635 471853001542 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 471853001543 putative nucleotide binding site [chemical binding]; other site 471853001544 putative catalytic residues [active] 471853001545 putative Mg ion binding site [ion binding]; other site 471853001546 putative aspartate binding site [chemical binding]; other site 471853001547 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 471853001548 putative allosteric regulatory site; other site 471853001549 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 471853001550 putative allosteric regulatory residue; other site 471853001551 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 471853001552 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471853001553 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853001554 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 471853001555 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853001556 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853001557 homodimer interface [polypeptide binding]; other site 471853001558 catalytic residue [active] 471853001559 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853001560 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001561 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001562 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853001563 putative substrate translocation pore; other site 471853001564 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853001565 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471853001566 CopC domain; Region: CopC; pfam04234 471853001567 Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079 471853001568 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471853001569 tetramer interface [polypeptide binding]; other site 471853001570 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 471853001571 active site 471853001572 Mg2+/Mn2+ binding site [ion binding]; other site 471853001573 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853001574 Sulfatase; Region: Sulfatase; cl17466 471853001575 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853001576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001577 dimer interface [polypeptide binding]; other site 471853001578 conserved gate region; other site 471853001579 putative PBP binding loops; other site 471853001580 ABC-ATPase subunit interface; other site 471853001581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001582 dimer interface [polypeptide binding]; other site 471853001583 conserved gate region; other site 471853001584 putative PBP binding loops; other site 471853001585 ABC-ATPase subunit interface; other site 471853001586 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853001587 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853001588 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 471853001589 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 471853001590 citrate synthase; Provisional; Region: PRK14033 471853001591 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 471853001592 oxalacetate binding site [chemical binding]; other site 471853001593 citrylCoA binding site [chemical binding]; other site 471853001594 coenzyme A binding site [chemical binding]; other site 471853001595 catalytic triad [active] 471853001596 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 471853001597 nudix motif; other site 471853001598 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 471853001599 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 471853001600 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471853001601 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 471853001602 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853001603 catalytic residue [active] 471853001604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001605 D-galactonate transporter; Region: 2A0114; TIGR00893 471853001606 putative substrate translocation pore; other site 471853001607 membrane protein FdrA; Validated; Region: PRK06091 471853001608 CoA binding domain; Region: CoA_binding; pfam02629 471853001609 CoA-ligase; Region: Ligase_CoA; pfam00549 471853001610 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 471853001611 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 471853001612 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001613 D-galactonate transporter; Region: 2A0114; TIGR00893 471853001614 putative substrate translocation pore; other site 471853001615 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 471853001616 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 471853001617 putative substrate binding site [chemical binding]; other site 471853001618 nucleotide binding site [chemical binding]; other site 471853001619 nucleotide binding site [chemical binding]; other site 471853001620 homodimer interface [polypeptide binding]; other site 471853001621 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471853001622 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853001623 DNA-binding site [nucleotide binding]; DNA binding site 471853001624 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471853001625 RibD C-terminal domain; Region: RibD_C; cl17279 471853001626 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471853001627 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471853001628 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853001629 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853001630 active site 471853001631 phosphorylation site [posttranslational modification] 471853001632 intermolecular recognition site; other site 471853001633 dimerization interface [polypeptide binding]; other site 471853001634 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001635 DNA binding residues [nucleotide binding] 471853001636 dimerization interface [polypeptide binding]; other site 471853001637 Histidine kinase; Region: HisKA_3; pfam07730 471853001638 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 471853001639 galactarate dehydratase; Region: galactar-dH20; TIGR03248 471853001640 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 471853001641 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471853001642 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471853001643 active site 471853001644 trimer interface [polypeptide binding]; other site 471853001645 allosteric site; other site 471853001646 active site lid [active] 471853001647 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471853001648 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853001649 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471853001650 active site 471853001651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853001652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853001653 DNA binding site [nucleotide binding] 471853001654 domain linker motif; other site 471853001655 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853001656 dimerization interface [polypeptide binding]; other site 471853001657 ligand binding site [chemical binding]; other site 471853001658 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853001659 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853001660 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853001661 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853001662 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 471853001663 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853001664 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001665 dimer interface [polypeptide binding]; other site 471853001666 conserved gate region; other site 471853001667 putative PBP binding loops; other site 471853001668 ABC-ATPase subunit interface; other site 471853001669 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853001670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001671 dimer interface [polypeptide binding]; other site 471853001672 conserved gate region; other site 471853001673 putative PBP binding loops; other site 471853001674 ABC-ATPase subunit interface; other site 471853001675 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853001676 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853001677 Walker A/P-loop; other site 471853001678 ATP binding site [chemical binding]; other site 471853001679 Q-loop/lid; other site 471853001680 ABC transporter signature motif; other site 471853001681 Walker B; other site 471853001682 D-loop; other site 471853001683 H-loop/switch region; other site 471853001684 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853001685 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853001686 Walker A/P-loop; other site 471853001687 ATP binding site [chemical binding]; other site 471853001688 Q-loop/lid; other site 471853001689 ABC transporter signature motif; other site 471853001690 Walker B; other site 471853001691 D-loop; other site 471853001692 H-loop/switch region; other site 471853001693 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853001694 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853001695 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853001696 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853001697 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 471853001698 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471853001699 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471853001700 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 471853001701 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853001702 putative active site [active] 471853001703 putative metal binding site [ion binding]; other site 471853001704 Transglycosylase; Region: Transgly; pfam00912 471853001705 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471853001706 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 471853001707 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853001708 Transcription factor WhiB; Region: Whib; pfam02467 471853001709 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 471853001710 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 471853001711 homotrimer interaction site [polypeptide binding]; other site 471853001712 putative active site [active] 471853001713 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 471853001714 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 471853001715 ligand binding site [chemical binding]; other site 471853001716 flexible hinge region; other site 471853001717 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471853001718 putative switch regulator; other site 471853001719 non-specific DNA interactions [nucleotide binding]; other site 471853001720 DNA binding site [nucleotide binding] 471853001721 sequence specific DNA binding site [nucleotide binding]; other site 471853001722 putative cAMP binding site [chemical binding]; other site 471853001723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853001724 S-adenosylmethionine binding site [chemical binding]; other site 471853001725 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471853001726 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471853001727 Serine hydrolase (FSH1); Region: FSH1; pfam03959 471853001728 acetyl-CoA synthetase; Provisional; Region: PRK00174 471853001729 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 471853001730 active site 471853001731 CoA binding site [chemical binding]; other site 471853001732 acyl-activating enzyme (AAE) consensus motif; other site 471853001733 AMP binding site [chemical binding]; other site 471853001734 acetate binding site [chemical binding]; other site 471853001735 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853001736 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001737 PAS domain; Region: PAS_9; pfam13426 471853001738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471853001739 putative active site [active] 471853001740 heme pocket [chemical binding]; other site 471853001741 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 471853001742 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 471853001743 Type II/IV secretion system protein; Region: T2SE; pfam00437 471853001744 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 471853001745 ATP binding site [chemical binding]; other site 471853001746 Walker A motif; other site 471853001747 hexamer interface [polypeptide binding]; other site 471853001748 Walker B motif; other site 471853001749 helicase/secretion neighborhood putative DEAH-box helicase; Region: DECH_helic; TIGR03817 471853001750 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853001751 ATP binding site [chemical binding]; other site 471853001752 putative Mg++ binding site [ion binding]; other site 471853001753 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 471853001754 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853001755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853001756 DNA binding site [nucleotide binding] 471853001757 Peptidase S8 family domain in BacillopeptidaseF-like proteins; Region: Peptidases_S8_BacillopeptidaseF-like; cd07481 471853001758 active site 471853001759 catalytic triad [active] 471853001760 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471853001761 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471853001762 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471853001763 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 471853001764 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471853001765 anti sigma factor interaction site; other site 471853001766 regulatory phosphorylation site [posttranslational modification]; other site 471853001767 arginine-tRNA ligase; Region: PLN02286 471853001768 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 471853001769 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 471853001770 active site 471853001771 HIGH motif; other site 471853001772 KMSK motif region; other site 471853001773 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 471853001774 tRNA binding surface [nucleotide binding]; other site 471853001775 anticodon binding site; other site 471853001776 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471853001777 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853001778 DNA binding residues [nucleotide binding] 471853001779 membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733 471853001780 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 471853001781 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853001782 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853001783 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 471853001784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853001785 S-adenosylmethionine binding site [chemical binding]; other site 471853001786 Protein of unknown function (DUF2871); Region: DUF2871; pfam11070 471853001787 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 471853001788 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001789 NAD(P) binding site [chemical binding]; other site 471853001790 active site 471853001791 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 471853001792 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471853001793 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853001794 metal binding site [ion binding]; metal-binding site 471853001795 substrate binding pocket [chemical binding]; other site 471853001796 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853001797 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471853001798 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853001799 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853001800 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001801 dimer interface [polypeptide binding]; other site 471853001802 conserved gate region; other site 471853001803 putative PBP binding loops; other site 471853001804 ABC-ATPase subunit interface; other site 471853001805 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853001806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853001807 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853001808 dimer interface [polypeptide binding]; other site 471853001809 ABC-ATPase subunit interface; other site 471853001810 putative PBP binding loops; other site 471853001811 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853001812 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853001813 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853001814 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 471853001815 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853001816 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 471853001817 putative hydrophobic ligand binding site [chemical binding]; other site 471853001818 CLM binding site; other site 471853001819 L1 loop; other site 471853001820 DNA binding site [nucleotide binding] 471853001821 Ku protein, prokaryotic; Region: Ku_bact; TIGR02772 471853001822 Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789 471853001823 putative DNA binding site [nucleotide binding]; other site 471853001824 putative homodimer interface [polypeptide binding]; other site 471853001825 ATP-dependent DNA ligase; Reviewed; Region: PRK09632 471853001826 MtLigD_Pol_like: Polymerase (Pol) domain of bacterial LigD proteins similar to Mycobacterium tuberculosis (Mt)LigD. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required for...; Region: MtLigD_Pol_like; cd04863 471853001827 nucleotide binding site [chemical binding]; other site 471853001828 DNA polymerase Ligase (LigD); Region: LigD_N; cl11819 471853001829 Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906 471853001830 active site 471853001831 DNA binding site [nucleotide binding] 471853001832 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971 471853001833 DNA binding site [nucleotide binding] 471853001834 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853001835 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853001836 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853001837 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853001838 active site 471853001839 PAP2 superfamily; Region: PAP2; pfam01569 471853001840 active site 471853001841 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 471853001842 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 471853001843 active site 471853001844 interdomain interaction site; other site 471853001845 putative metal-binding site [ion binding]; other site 471853001846 nucleotide binding site [chemical binding]; other site 471853001847 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 471853001848 domain I; other site 471853001849 phosphate binding site [ion binding]; other site 471853001850 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 471853001851 domain II; other site 471853001852 domain III; other site 471853001853 nucleotide binding site [chemical binding]; other site 471853001854 DNA binding groove [nucleotide binding] 471853001855 catalytic site [active] 471853001856 domain IV; other site 471853001857 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471853001858 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 471853001859 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853001860 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853001861 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853001862 DinB superfamily; Region: DinB_2; pfam12867 471853001863 thymidylate kinase; Validated; Region: tmk; PRK00698 471853001864 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 471853001865 TMP-binding site; other site 471853001866 ATP-binding site [chemical binding]; other site 471853001867 DNA polymerase III subunit delta'; Validated; Region: PRK07940 471853001868 DNA polymerase III subunit delta'; Validated; Region: PRK08485 471853001869 TAP-like protein; Region: Abhydrolase_4; pfam08386 471853001870 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 471853001871 nucleotide binding site [chemical binding]; other site 471853001872 putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208 471853001873 oligomer interface [polypeptide binding]; other site 471853001874 hypothetical protein; Provisional; Region: PRK02237 471853001875 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853001876 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853001877 DNA binding residues [nucleotide binding] 471853001878 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471853001879 DNA-binding site [nucleotide binding]; DNA binding site 471853001880 RNA-binding motif; other site 471853001881 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471853001882 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 471853001883 putative di-iron ligands [ion binding]; other site 471853001884 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471853001885 nudix motif; other site 471853001886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853001887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853001888 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853001889 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853001890 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853001891 Walker A/P-loop; other site 471853001892 ATP binding site [chemical binding]; other site 471853001893 Q-loop/lid; other site 471853001894 ABC transporter signature motif; other site 471853001895 Walker B; other site 471853001896 D-loop; other site 471853001897 H-loop/switch region; other site 471853001898 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471853001899 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471853001900 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853001901 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471853001902 NAD(P) binding site [chemical binding]; other site 471853001903 active site 471853001904 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853001905 active site 471853001906 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853001907 catalytic tetrad [active] 471853001908 Predicted phosphatase [General function prediction only]; Region: PhoX; COG3211 471853001909 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853001910 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853001911 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853001912 DNA binding residues [nucleotide binding] 471853001913 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853001914 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853001915 active site 471853001916 catalytic site [active] 471853001917 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853001918 FAD binding domain; Region: FAD_binding_4; pfam01565 471853001919 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 471853001920 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 471853001921 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 471853001922 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471853001923 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471853001924 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 471853001925 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 471853001926 O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK07812 471853001927 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471853001928 homodimer interface [polypeptide binding]; other site 471853001929 substrate-cofactor binding pocket; other site 471853001930 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853001931 catalytic residue [active] 471853001932 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471853001933 NlpC/P60 family; Region: NLPC_P60; pfam00877 471853001934 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 471853001935 dimer interface [polypeptide binding]; other site 471853001936 substrate binding site [chemical binding]; other site 471853001937 metal binding sites [ion binding]; metal-binding site 471853001938 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 471853001939 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 471853001940 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 471853001941 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 471853001942 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 471853001943 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 471853001944 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853001945 active site 471853001946 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 471853001947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853001948 Walker A motif; other site 471853001949 ATP binding site [chemical binding]; other site 471853001950 Walker B motif; other site 471853001951 arginine finger; other site 471853001952 Peptidase family M41; Region: Peptidase_M41; pfam01434 471853001953 GTP cyclohydrolase I; Provisional; Region: PLN03044 471853001954 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 471853001955 homodecamer interface [polypeptide binding]; other site 471853001956 active site 471853001957 putative catalytic site residues [active] 471853001958 zinc binding site [ion binding]; other site 471853001959 GTP-CH-I/GFRP interaction surface; other site 471853001960 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 471853001961 dihydropteroate synthase; Region: DHPS; TIGR01496 471853001962 substrate binding pocket [chemical binding]; other site 471853001963 dimer interface [polypeptide binding]; other site 471853001964 inhibitor binding site; inhibition site 471853001965 Dihydroneopterin aldolase [Coenzyme metabolism]; Region: FolB; COG1539 471853001966 active site 471853001967 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 471853001968 catalytic center binding site [active] 471853001969 ATP binding site [chemical binding]; other site 471853001970 Uncharacterized conserved protein [Function unknown]; Region: COG3402 471853001971 Bacterial PH domain; Region: DUF304; pfam03703 471853001972 Bacterial PH domain; Region: DUF304; cl01348 471853001973 Bacterial PH domain; Region: DUF304; pfam03703 471853001974 Protein of unknown function (DUF1684); Region: DUF1684; cl01327 471853001975 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 471853001976 nudix motif; other site 471853001977 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853001978 MarR family; Region: MarR; pfam01047 471853001979 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853001980 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853001981 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 471853001982 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853001983 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 471853001984 catalytic site [active] 471853001985 Rossmann-like domain; Region: Rossmann-like; pfam10727 471853001986 Domain of unknown function (DUF2520); Region: DUF2520; pfam10728 471853001987 pantoate--beta-alanine ligase; Reviewed; Region: panC; PRK00380 471853001988 active site 471853001989 nucleotide binding site [chemical binding]; other site 471853001990 HIGH motif; other site 471853001991 KMSKS motif; other site 471853001992 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853001993 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853001994 active site 471853001995 phosphorylation site [posttranslational modification] 471853001996 intermolecular recognition site; other site 471853001997 dimerization interface [polypeptide binding]; other site 471853001998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853001999 DNA binding residues [nucleotide binding] 471853002000 dimerization interface [polypeptide binding]; other site 471853002001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853002002 Histidine kinase; Region: HisKA_3; pfam07730 471853002003 Protein of unknown function (DUF418); Region: DUF418; pfam04235 471853002004 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 471853002005 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 471853002006 dimer interface [polypeptide binding]; other site 471853002007 putative anticodon binding site; other site 471853002008 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471853002009 motif 1; other site 471853002010 dimer interface [polypeptide binding]; other site 471853002011 active site 471853002012 motif 2; other site 471853002013 motif 3; other site 471853002014 Lsr2; Region: Lsr2; pfam11774 471853002015 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 471853002016 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471853002017 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853002018 DNA-binding site [nucleotide binding]; DNA binding site 471853002019 UTRA domain; Region: UTRA; pfam07702 471853002020 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853002021 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471853002022 substrate binding site [chemical binding]; other site 471853002023 ATP binding site [chemical binding]; other site 471853002024 KduI/IolB family; Region: KduI; pfam04962 471853002025 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 471853002026 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471853002027 PYR/PP interface [polypeptide binding]; other site 471853002028 dimer interface [polypeptide binding]; other site 471853002029 TPP binding site [chemical binding]; other site 471853002030 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471853002031 Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003 471853002032 TPP-binding site; other site 471853002033 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 471853002034 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 471853002035 tetrameric interface [polypeptide binding]; other site 471853002036 NAD binding site [chemical binding]; other site 471853002037 catalytic residues [active] 471853002038 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471853002039 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853002040 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853002041 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853002042 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853002043 catalytic core [active] 471853002044 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853002045 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853002046 Sulfatase; Region: Sulfatase; pfam00884 471853002047 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 471853002048 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 471853002049 Protein of unknown function (DUF1214); Region: DUF1214; pfam06742 471853002050 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853002051 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 471853002052 tetramerization interface [polypeptide binding]; other site 471853002053 NAD(P) binding site [chemical binding]; other site 471853002054 catalytic residues [active] 471853002055 Short C-terminal domain; Region: SHOCT; pfam09851 471853002056 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853002057 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 471853002058 DNA binding residues [nucleotide binding] 471853002059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002060 putative substrate translocation pore; other site 471853002061 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853002062 HTH domain; Region: HTH_11; pfam08279 471853002063 WYL domain; Region: WYL; pfam13280 471853002064 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 471853002065 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471853002066 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853002067 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853002068 DNA binding residues [nucleotide binding] 471853002069 dimerization interface [polypeptide binding]; other site 471853002070 Protease prsW family; Region: PrsW-protease; pfam13367 471853002071 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471853002072 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471853002073 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471853002074 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471853002075 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471853002076 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 471853002077 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471853002078 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471853002079 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 471853002080 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 471853002081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471853002082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853002083 dimerization interface [polypeptide binding]; other site 471853002084 Protein of unknown function (DUF2910); Region: DUF2910; pfam11139 471853002085 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 471853002086 Uncharacterized conserved protein [Function unknown]; Region: COG1262 471853002087 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 471853002088 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853002089 Sulfatase; Region: Sulfatase; pfam00884 471853002090 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853002091 Sulfatase; Region: Sulfatase; pfam00884 471853002092 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853002093 Sulfatase; Region: Sulfatase; pfam00884 471853002094 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471853002095 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 471853002096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853002097 Q-loop/lid; other site 471853002098 ABC transporter signature motif; other site 471853002099 Walker B; other site 471853002100 D-loop; other site 471853002101 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 471853002102 Sulfate transporter family; Region: Sulfate_transp; pfam00916 471853002103 AAA ATPase domain; Region: AAA_16; pfam13191 471853002104 AAA domain; Region: AAA_22; pfam13401 471853002105 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853002106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853002107 DNA binding residues [nucleotide binding] 471853002108 dimerization interface [polypeptide binding]; other site 471853002109 DinB superfamily; Region: DinB_2; pfam12867 471853002110 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 471853002111 PhoU domain; Region: PhoU; pfam01895 471853002112 PhoU domain; Region: PhoU; pfam01895 471853002113 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471853002114 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853002115 dimer interface [polypeptide binding]; other site 471853002116 phosphorylation site [posttranslational modification] 471853002117 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853002118 ATP binding site [chemical binding]; other site 471853002119 Mg2+ binding site [ion binding]; other site 471853002120 G-X-G motif; other site 471853002121 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853002122 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002123 active site 471853002124 phosphorylation site [posttranslational modification] 471853002125 intermolecular recognition site; other site 471853002126 dimerization interface [polypeptide binding]; other site 471853002127 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853002128 DNA binding site [nucleotide binding] 471853002129 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 471853002130 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 471853002131 substrate binding site; other site 471853002132 dimer interface; other site 471853002133 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 471853002134 homotrimer interaction site [polypeptide binding]; other site 471853002135 zinc binding site [ion binding]; other site 471853002136 CDP-binding sites; other site 471853002137 MarR family; Region: MarR_2; cl17246 471853002138 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853002139 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853002140 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853002141 Walker A/P-loop; other site 471853002142 ATP binding site [chemical binding]; other site 471853002143 Q-loop/lid; other site 471853002144 ABC transporter signature motif; other site 471853002145 Walker B; other site 471853002146 D-loop; other site 471853002147 H-loop/switch region; other site 471853002148 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471853002149 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471853002150 DNA binding site [nucleotide binding] 471853002151 active site 471853002152 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 471853002153 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853002154 active site 471853002155 HIGH motif; other site 471853002156 nucleotide binding site [chemical binding]; other site 471853002157 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 471853002158 KMSKS motif; other site 471853002159 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 471853002160 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471853002161 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 471853002162 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471853002163 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 471853002164 TM1410 hypothetical-related protein; Region: DUF297; pfam03537 471853002165 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 471853002166 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853002167 Walker A/P-loop; other site 471853002168 ATP binding site [chemical binding]; other site 471853002169 Q-loop/lid; other site 471853002170 ABC transporter signature motif; other site 471853002171 Walker B; other site 471853002172 D-loop; other site 471853002173 H-loop/switch region; other site 471853002174 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471853002175 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 471853002176 Walker A/P-loop; other site 471853002177 ATP binding site [chemical binding]; other site 471853002178 Q-loop/lid; other site 471853002179 ABC transporter signature motif; other site 471853002180 Walker B; other site 471853002181 D-loop; other site 471853002182 H-loop/switch region; other site 471853002183 TOBE domain; Region: TOBE; pfam03459 471853002184 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 471853002185 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 471853002186 dimer interface [polypeptide binding]; other site 471853002187 NADP binding site [chemical binding]; other site 471853002188 catalytic residues [active] 471853002189 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853002190 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853002191 active site pocket [active] 471853002192 Class I aldolases; Region: Aldolase_Class_I; cl17187 471853002193 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853002194 catalytic residue [active] 471853002195 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853002196 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002197 NAD(P) binding site [chemical binding]; other site 471853002198 active site 471853002199 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853002200 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853002201 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853002202 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002204 dimer interface [polypeptide binding]; other site 471853002205 conserved gate region; other site 471853002206 putative PBP binding loops; other site 471853002207 ABC-ATPase subunit interface; other site 471853002208 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853002209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002210 ABC-ATPase subunit interface; other site 471853002211 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002212 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853002213 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853002214 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853002215 DNA binding site [nucleotide binding] 471853002216 domain linker motif; other site 471853002217 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853002218 dimerization interface [polypeptide binding]; other site 471853002219 ligand binding site [chemical binding]; other site 471853002220 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 471853002221 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 471853002222 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 471853002223 active site 471853002224 homotetramer interface [polypeptide binding]; other site 471853002225 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471853002226 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471853002227 active site 471853002228 ATP binding site [chemical binding]; other site 471853002229 substrate binding site [chemical binding]; other site 471853002230 activation loop (A-loop); other site 471853002231 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471853002232 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 471853002233 catalytic residues [active] 471853002234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853002235 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 471853002236 putative dimerization interface [polypeptide binding]; other site 471853002237 putative ligand binding site [chemical binding]; other site 471853002238 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853002239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853002240 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853002241 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002242 dimer interface [polypeptide binding]; other site 471853002243 conserved gate region; other site 471853002244 putative PBP binding loops; other site 471853002245 ABC-ATPase subunit interface; other site 471853002246 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002247 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002248 dimer interface [polypeptide binding]; other site 471853002249 conserved gate region; other site 471853002250 putative PBP binding loops; other site 471853002251 ABC-ATPase subunit interface; other site 471853002252 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853002253 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853002254 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853002255 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853002256 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853002257 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002258 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853002259 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853002260 classical (c) SDRs; Region: SDR_c; cd05233 471853002261 NAD(P) binding site [chemical binding]; other site 471853002262 active site 471853002263 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853002264 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853002265 PQQ-like domain; Region: PQQ_2; pfam13360 471853002266 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 471853002267 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471853002268 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_1; cd01832 471853002269 active site 471853002270 catalytic triad [active] 471853002271 oxyanion hole [active] 471853002272 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 471853002273 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 471853002274 ligand binding site [chemical binding]; other site 471853002275 active site 471853002276 UGI interface [polypeptide binding]; other site 471853002277 catalytic site [active] 471853002278 Protein of unknown function (DUF3263); Region: DUF3263; pfam11662 471853002279 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 471853002280 malate:quinone oxidoreductase; Validated; Region: PRK05257 471853002281 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 471853002282 Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387 471853002283 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471853002284 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471853002285 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 471853002286 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 471853002287 ring oligomerisation interface [polypeptide binding]; other site 471853002288 ATP/Mg binding site [chemical binding]; other site 471853002289 stacking interactions; other site 471853002290 hinge regions; other site 471853002291 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471853002292 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853002293 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 471853002294 MgtC family; Region: MgtC; pfam02308 471853002295 FOG: CBS domain [General function prediction only]; Region: COG0517 471853002296 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 471853002297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853002298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853002299 DNA binding site [nucleotide binding] 471853002300 domain linker motif; other site 471853002301 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853002302 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 471853002303 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 471853002304 substrate binding [chemical binding]; other site 471853002305 active site 471853002306 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002308 dimer interface [polypeptide binding]; other site 471853002309 conserved gate region; other site 471853002310 putative PBP binding loops; other site 471853002311 ABC-ATPase subunit interface; other site 471853002312 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853002313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002314 dimer interface [polypeptide binding]; other site 471853002315 conserved gate region; other site 471853002316 putative PBP binding loops; other site 471853002317 ABC-ATPase subunit interface; other site 471853002318 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002319 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853002320 Protein of unknown function (DUF4031); Region: DUF4031; pfam13223 471853002321 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 471853002322 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002323 NAD(P) binding site [chemical binding]; other site 471853002324 active site 471853002325 Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640 471853002326 dimerization interface [polypeptide binding]; other site 471853002327 putative DNA binding site [nucleotide binding]; other site 471853002328 putative Zn2+ binding site [ion binding]; other site 471853002329 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 471853002330 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 471853002331 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 471853002332 NAD(P) binding site [chemical binding]; other site 471853002333 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 471853002334 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 471853002335 substrate-cofactor binding pocket; other site 471853002336 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002337 catalytic residue [active] 471853002338 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 471853002339 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4339 471853002340 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471853002341 dimerization interface [polypeptide binding]; other site 471853002342 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471853002343 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853002344 dimer interface [polypeptide binding]; other site 471853002345 phosphorylation site [posttranslational modification] 471853002346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853002347 Mg2+ binding site [ion binding]; other site 471853002348 G-X-G motif; other site 471853002349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853002350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002351 active site 471853002352 phosphorylation site [posttranslational modification] 471853002353 intermolecular recognition site; other site 471853002354 dimerization interface [polypeptide binding]; other site 471853002355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853002356 DNA binding site [nucleotide binding] 471853002357 LabA_like proteins; Region: LabA_like; cd06167 471853002358 putative metal binding site [ion binding]; other site 471853002359 PspA/IM30 family; Region: PspA_IM30; pfam04012 471853002360 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 471853002361 catalytic triad [active] 471853002362 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471853002363 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002364 putative substrate translocation pore; other site 471853002365 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 471853002366 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 471853002367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853002368 ATP binding site [chemical binding]; other site 471853002369 putative Mg++ binding site [ion binding]; other site 471853002370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853002371 nucleotide binding region [chemical binding]; other site 471853002372 ATP-binding site [chemical binding]; other site 471853002373 Helicase conserved C-terminal domain; Region: Helicase_C_3; pfam13625 471853002374 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471853002375 DNA-binding site [nucleotide binding]; DNA binding site 471853002376 RNA-binding motif; other site 471853002377 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 471853002378 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 471853002379 putative metal binding residues [ion binding]; other site 471853002380 signature motif; other site 471853002381 dimer interface [polypeptide binding]; other site 471853002382 active site 471853002383 polyP binding site; other site 471853002384 substrate binding site [chemical binding]; other site 471853002385 acceptor-phosphate pocket; other site 471853002386 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853002387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002388 active site 471853002389 phosphorylation site [posttranslational modification] 471853002390 intermolecular recognition site; other site 471853002391 dimerization interface [polypeptide binding]; other site 471853002392 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853002393 DNA binding site [nucleotide binding] 471853002394 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 471853002395 putative binding surface; other site 471853002396 active site 471853002397 Response regulator receiver domain; Region: Response_reg; pfam00072 471853002398 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002399 active site 471853002400 phosphorylation site [posttranslational modification] 471853002401 intermolecular recognition site; other site 471853002402 dimerization interface [polypeptide binding]; other site 471853002403 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 471853002404 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 471853002405 putative active site [active] 471853002406 heme pocket [chemical binding]; other site 471853002407 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853002408 dimer interface [polypeptide binding]; other site 471853002409 phosphorylation site [posttranslational modification] 471853002410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853002411 ATP binding site [chemical binding]; other site 471853002412 Mg2+ binding site [ion binding]; other site 471853002413 G-X-G motif; other site 471853002414 Pyruvoyl-dependent arginine decarboxylase (PvlArgDC); Region: PvlArgDC; cl00849 471853002415 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 471853002416 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 471853002417 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 471853002418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853002419 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002420 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 471853002421 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 471853002422 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 471853002423 tetramer interface [polypeptide binding]; other site 471853002424 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 471853002425 tetramer interface [polypeptide binding]; other site 471853002426 active site 471853002427 metal binding site [ion binding]; metal-binding site 471853002428 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 471853002429 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853002430 NAD(P) binding site [chemical binding]; other site 471853002431 catalytic residues [active] 471853002432 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853002433 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471853002434 dimer interface [polypeptide binding]; other site 471853002435 active site 471853002436 catalytic residue [active] 471853002437 hypothetical protein; Provisional; Region: PRK12764 471853002438 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471853002439 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471853002440 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-1; TIGR02309 471853002441 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 471853002442 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 471853002443 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853002444 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853002445 putative DNA binding site [nucleotide binding]; other site 471853002446 putative Zn2+ binding site [ion binding]; other site 471853002447 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471853002448 PYR/PP interface [polypeptide binding]; other site 471853002449 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 471853002450 dimer interface [polypeptide binding]; other site 471853002451 TPP binding site [chemical binding]; other site 471853002452 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471853002453 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 471853002454 TPP-binding site [chemical binding]; other site 471853002455 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853002456 MarR family; Region: MarR; pfam01047 471853002457 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853002458 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002459 putative substrate translocation pore; other site 471853002460 HNH/ENDO VII superfamily nuclease with conserved GHE residues; Region: GH-E; pfam14410 471853002461 FOG: Ankyrin repeat [General function prediction only]; Region: Arp; COG0666 471853002462 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471853002463 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 471853002464 phosphoserine aminotransferase; Provisional; Region: PRK03080 471853002465 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853002466 catalytic residue [active] 471853002467 citrate synthase 2; Provisional; Region: PRK12350 471853002468 Citrate synthase; Region: Citrate_synt; pfam00285 471853002469 citrylCoA binding site [chemical binding]; other site 471853002470 oxalacetate binding site [chemical binding]; other site 471853002471 coenzyme A binding site [chemical binding]; other site 471853002472 catalytic triad [active] 471853002473 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 471853002474 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 471853002475 non-specific DNA interactions [nucleotide binding]; other site 471853002476 DNA binding site [nucleotide binding] 471853002477 sequence specific DNA binding site [nucleotide binding]; other site 471853002478 putative cAMP binding site [chemical binding]; other site 471853002479 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471853002480 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 471853002481 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 471853002482 NlpC/P60 family; Region: NLPC_P60; pfam00877 471853002483 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471853002484 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471853002485 Ligand Binding Site [chemical binding]; other site 471853002486 Domain of unknown function (DUF305); Region: DUF305; pfam03713 471853002487 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471853002488 ornithine aminotransferase; Region: Orn_aminotrans; TIGR01885 471853002489 inhibitor-cofactor binding pocket; inhibition site 471853002490 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002491 catalytic residue [active] 471853002492 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 471853002493 Amidinotransferase; Region: Amidinotransf; cl12043 471853002494 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471853002495 hydrophobic ligand binding site; other site 471853002496 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471853002497 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853002498 motif II; other site 471853002499 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 471853002500 Asp-box motif; other site 471853002501 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 471853002502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853002503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853002504 DNA binding site [nucleotide binding] 471853002505 domain linker motif; other site 471853002506 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853002507 dimerization interface [polypeptide binding]; other site 471853002508 ligand binding site [chemical binding]; other site 471853002509 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 471853002510 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853002511 active site 471853002512 catalytic site [active] 471853002513 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002514 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853002515 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002516 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002517 dimer interface [polypeptide binding]; other site 471853002518 conserved gate region; other site 471853002519 putative PBP binding loops; other site 471853002520 ABC-ATPase subunit interface; other site 471853002521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002522 dimer interface [polypeptide binding]; other site 471853002523 conserved gate region; other site 471853002524 putative PBP binding loops; other site 471853002525 ABC-ATPase subunit interface; other site 471853002526 benzoate transport; Region: 2A0115; TIGR00895 471853002527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002528 putative substrate translocation pore; other site 471853002529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002530 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 471853002531 putative active site [active] 471853002532 catalytic triad [active] 471853002533 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 471853002534 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 471853002535 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 471853002536 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 471853002537 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 471853002538 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471853002539 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 471853002540 active site 471853002541 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 471853002542 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 471853002543 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471853002544 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471853002545 dimer interface [polypeptide binding]; other site 471853002546 putative functional site; other site 471853002547 putative MPT binding site; other site 471853002548 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853002549 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471853002550 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853002551 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002552 NAD(P) binding site [chemical binding]; other site 471853002553 active site 471853002554 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 471853002555 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471853002556 metal binding site [ion binding]; metal-binding site 471853002557 substrate binding pocket [chemical binding]; other site 471853002558 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002559 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853002560 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002561 dimer interface [polypeptide binding]; other site 471853002562 conserved gate region; other site 471853002563 putative PBP binding loops; other site 471853002564 ABC-ATPase subunit interface; other site 471853002565 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002566 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002567 dimer interface [polypeptide binding]; other site 471853002568 conserved gate region; other site 471853002569 putative PBP binding loops; other site 471853002570 ABC-ATPase subunit interface; other site 471853002571 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853002572 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853002573 DNA binding site [nucleotide binding] 471853002574 domain linker motif; other site 471853002575 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853002576 dimerization interface [polypeptide binding]; other site 471853002577 ligand binding site [chemical binding]; other site 471853002578 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 471853002579 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_5; cd09621 471853002580 putative ligand binding site [chemical binding]; other site 471853002581 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853002582 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 471853002583 putative ligand binding site [chemical binding]; other site 471853002584 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 471853002585 putative NAD binding site [chemical binding]; other site 471853002586 catalytic site [active] 471853002587 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853002588 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853002589 dimerization interface [polypeptide binding]; other site 471853002590 ligand binding site [chemical binding]; other site 471853002591 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002592 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853002593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002594 dimer interface [polypeptide binding]; other site 471853002595 conserved gate region; other site 471853002596 putative PBP binding loops; other site 471853002597 ABC-ATPase subunit interface; other site 471853002598 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002600 dimer interface [polypeptide binding]; other site 471853002601 conserved gate region; other site 471853002602 putative PBP binding loops; other site 471853002603 ABC-ATPase subunit interface; other site 471853002604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853002605 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853002606 DNA binding residues [nucleotide binding] 471853002607 dimerization interface [polypeptide binding]; other site 471853002608 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471853002609 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 471853002610 Intradiol dioxygenase supgroup. Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. They break the catechol C1-C2 bond and utilize Fe3+, as opposed to the...; Region: intradiol_dioxygenase_like; cd03457 471853002611 putative active site [active] 471853002612 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853002613 active site 471853002614 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 471853002615 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853002616 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471853002617 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853002618 FAD binding domain; Region: FAD_binding_4; pfam01565 471853002619 Berberine and berberine like; Region: BBE; pfam08031 471853002620 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853002621 MarR family; Region: MarR_2; pfam12802 471853002622 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853002623 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853002624 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853002625 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853002626 active site 471853002627 catalytic tetrad [active] 471853002628 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853002629 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471853002630 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853002631 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853002632 catalytic residue [active] 471853002633 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 471853002634 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 471853002635 putative dimer interface [polypeptide binding]; other site 471853002636 N-terminal domain interface [polypeptide binding]; other site 471853002637 putative substrate binding pocket (H-site) [chemical binding]; other site 471853002638 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 471853002639 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853002640 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853002641 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471853002642 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853002643 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853002644 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853002645 binding surface 471853002646 TPR motif; other site 471853002647 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 471853002648 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853002649 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853002650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853002651 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853002652 putative PBP binding loops; other site 471853002653 ABC-ATPase subunit interface; other site 471853002654 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853002655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853002656 Melibiase; Region: Melibiase; pfam02065 471853002657 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471853002658 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 471853002659 metal ion-dependent adhesion site (MIDAS); other site 471853002660 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 471853002661 Transposase; Region: HTH_Tnp_1; pfam01527 471853002662 A subgroup of the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the N-acetylhexosaminidase from Streptomyces plicatus (SpHex). SpHex catalyzes the hydrolysis of N-acetyl-beta-hexosaminides. An Asp residue within the...; Region: GH20_SpHex_like; cd06568 471853002663 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 471853002664 active site 471853002665 Protein of unknown function (DUF419); Region: DUF419; pfam04237 471853002666 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 471853002667 Predicted methyltransferases [General function prediction only]; Region: COG0313 471853002668 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 471853002669 putative SAM binding site [chemical binding]; other site 471853002670 putative homodimer interface [polypeptide binding]; other site 471853002671 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 471853002672 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853002673 P-loop; other site 471853002674 Magnesium ion binding site [ion binding]; other site 471853002675 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853002676 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853002677 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853002678 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471853002679 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 471853002680 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 471853002681 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 471853002682 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 471853002683 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471853002684 Interdomain contacts; other site 471853002685 Cytokine receptor motif; other site 471853002686 Bacterial Ig-like domain; Region: Big_5; pfam13205 471853002687 Di-glucose binding within endoplasmic reticulum; Region: Malectin; pfam11721 471853002688 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 471853002689 Isochorismatase family; Region: Isochorismatase; pfam00857 471853002690 catalytic triad [active] 471853002691 metal binding site [ion binding]; metal-binding site 471853002692 conserved cis-peptide bond; other site 471853002693 aminotransferase; Validated; Region: PRK08175 471853002694 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853002695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002696 homodimer interface [polypeptide binding]; other site 471853002697 catalytic residue [active] 471853002698 Tryptophan 2,3-dioxygenase; Region: Trp_dioxygenase; cl03994 471853002699 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853002700 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 471853002701 Part of AAA domain; Region: AAA_19; pfam13245 471853002702 Family description; Region: UvrD_C_2; pfam13538 471853002703 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853002704 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853002705 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 471853002706 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 471853002707 MMPL family; Region: MMPL; pfam03176 471853002708 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853002709 MarR family; Region: MarR_2; cl17246 471853002710 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 471853002711 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 471853002712 active site 471853002713 metal binding site [ion binding]; metal-binding site 471853002714 nudix motif; other site 471853002715 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471853002716 substrate binding pocket [chemical binding]; other site 471853002717 substrate-Mg2+ binding site; other site 471853002718 aspartate-rich region 1; other site 471853002719 aspartate-rich region 2; other site 471853002720 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 471853002721 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 471853002722 active site 471853002723 HIGH motif; other site 471853002724 KMSKS motif; other site 471853002725 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 471853002726 tRNA binding surface [nucleotide binding]; other site 471853002727 anticodon binding site; other site 471853002728 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 471853002729 active site 471853002730 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471853002731 G5 domain; Region: G5; pfam07501 471853002732 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471853002733 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471853002734 catalytic residue [active] 471853002735 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471853002736 Domain of unknown function (DUF348); Region: DUF348; pfam03990 471853002737 G5 domain; Region: G5; pfam07501 471853002738 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 471853002739 N-acetyl-D-glucosamine binding site [chemical binding]; other site 471853002740 catalytic residue [active] 471853002741 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 471853002742 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 471853002743 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 471853002744 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853002745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853002746 ABC transporter; Region: ABC_tran_2; pfam12848 471853002747 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853002748 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471853002749 Low molecular weight phosphatase family; Region: LMWPc; cl00105 471853002750 active site 471853002751 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 471853002752 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 471853002753 trimer interface [polypeptide binding]; other site 471853002754 putative metal binding site [ion binding]; other site 471853002755 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853002756 MarR family; Region: MarR_2; cl17246 471853002757 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471853002758 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471853002759 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471853002760 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853002761 Walker A/P-loop; other site 471853002762 ATP binding site [chemical binding]; other site 471853002763 Q-loop/lid; other site 471853002764 ABC transporter signature motif; other site 471853002765 Walker B; other site 471853002766 D-loop; other site 471853002767 H-loop/switch region; other site 471853002768 Predicted transcriptional regulators [Transcription]; Region: COG1725 471853002769 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853002770 DNA-binding site [nucleotide binding]; DNA binding site 471853002771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853002772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853002773 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 471853002774 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 471853002775 DXD motif; other site 471853002776 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 471853002777 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 471853002778 Substrate binding site; other site 471853002779 Mg++ binding site; other site 471853002780 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 471853002781 active site 471853002782 substrate binding site [chemical binding]; other site 471853002783 CoA binding site [chemical binding]; other site 471853002784 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 471853002785 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 471853002786 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853002787 active site 471853002788 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 471853002789 putative active site [active] 471853002790 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 471853002791 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 471853002792 5S rRNA interface [nucleotide binding]; other site 471853002793 CTC domain interface [polypeptide binding]; other site 471853002794 L16 interface [polypeptide binding]; other site 471853002795 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 471853002796 putative active site [active] 471853002797 catalytic residue [active] 471853002798 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853002799 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 471853002800 active site 471853002801 nucleotide binding site [chemical binding]; other site 471853002802 HIGH motif; other site 471853002803 KMSKS motif; other site 471853002804 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 471853002805 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471853002806 Probable Catalytic site; other site 471853002807 metal-binding site 471853002808 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 471853002809 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853002810 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 471853002811 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471853002812 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 471853002813 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471853002814 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853002815 active site 471853002816 Right handed beta helix region; Region: Beta_helix; pfam13229 471853002817 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853002818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853002819 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 471853002820 Chain length determinant protein; Region: Wzz; cl15801 471853002821 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 471853002822 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471853002823 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 471853002824 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 471853002825 active site 471853002826 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471853002827 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471853002828 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471853002829 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 471853002830 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 471853002831 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 471853002832 Ligand binding site; other site 471853002833 Putative Catalytic site; other site 471853002834 DXD motif; other site 471853002835 GtrA-like protein; Region: GtrA; pfam04138 471853002836 Up-frameshift suppressor 2; Region: Upf2; pfam04050 471853002837 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471853002838 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853002839 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853002840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853002841 Walker A/P-loop; other site 471853002842 ATP binding site [chemical binding]; other site 471853002843 Q-loop/lid; other site 471853002844 ABC transporter signature motif; other site 471853002845 Walker B; other site 471853002846 D-loop; other site 471853002847 H-loop/switch region; other site 471853002848 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 471853002849 putative active site pocket [active] 471853002850 dimerization interface [polypeptide binding]; other site 471853002851 putative catalytic residue [active] 471853002852 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 471853002853 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 471853002854 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853002855 ATP binding site [chemical binding]; other site 471853002856 putative Mg++ binding site [ion binding]; other site 471853002857 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853002858 nucleotide binding region [chemical binding]; other site 471853002859 ATP-binding site [chemical binding]; other site 471853002860 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 471853002861 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 471853002862 putative active site [active] 471853002863 putative metal binding site [ion binding]; other site 471853002864 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853002865 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853002866 catalytic core [active] 471853002867 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 471853002868 homodimer interface [polypeptide binding]; other site 471853002869 metal binding site [ion binding]; metal-binding site 471853002870 enolase; Provisional; Region: eno; PRK00077 471853002871 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 471853002872 dimer interface [polypeptide binding]; other site 471853002873 metal binding site [ion binding]; metal-binding site 471853002874 substrate binding pocket [chemical binding]; other site 471853002875 Septum formation initiator; Region: DivIC; pfam04977 471853002876 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 471853002877 Protein of unknown function (DUF501); Region: DUF501; pfam04417 471853002878 DNA polymerase IV; Validated; Region: PRK03858 471853002879 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471853002880 active site 471853002881 DNA binding site [nucleotide binding] 471853002882 exopolyphosphatase; Region: exo_poly_only; TIGR03706 471853002883 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 471853002884 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471853002885 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_6; cd07242 471853002886 putative dimer interface [polypeptide binding]; other site 471853002887 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853002888 ligand binding site [chemical binding]; other site 471853002889 Zn binding site [ion binding]; other site 471853002890 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853002891 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471853002892 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332 471853002893 putative deacylase active site [active] 471853002894 Family-5 Uracil-DNA glycosylases (UDG), found in thermophilic organisms; Region: UDG_F5_TTUDGB_like; cd10031 471853002895 Fe-S cluster binding site [ion binding]; other site 471853002896 DNA binding site [nucleotide binding] 471853002897 active site 471853002898 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471853002899 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 471853002900 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853002901 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471853002902 Protein of unknown function (DUF1048); Region: DUF1048; cl01986 471853002903 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471853002904 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853002905 Walker A/P-loop; other site 471853002906 ATP binding site [chemical binding]; other site 471853002907 Q-loop/lid; other site 471853002908 ABC transporter signature motif; other site 471853002909 Walker B; other site 471853002910 D-loop; other site 471853002911 H-loop/switch region; other site 471853002912 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471853002913 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471853002914 DNA polymerase IV; Validated; Region: PRK03352 471853002915 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471853002916 active site 471853002917 DNA binding site [nucleotide binding] 471853002918 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853002919 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853002920 NAD(P) binding site [chemical binding]; other site 471853002921 active site 471853002922 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 471853002923 bifunctional 3'-5' exonuclease/DNA polymerase; Provisional; Region: PRK14975 471853002924 Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cd06444 471853002925 active site 471853002926 DNA binding site [nucleotide binding] 471853002927 catalytic site [active] 471853002928 Uncharacterized conserved protein [Function unknown]; Region: COG1432 471853002929 LabA_like proteins; Region: LabA_like; cd06167 471853002930 putative metal binding site [ion binding]; other site 471853002931 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 471853002932 C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879 471853002933 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 471853002934 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853002935 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853002936 active site 471853002937 motif I; other site 471853002938 motif II; other site 471853002939 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853002940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853002941 active site 471853002942 phosphorylation site [posttranslational modification] 471853002943 intermolecular recognition site; other site 471853002944 dimerization interface [polypeptide binding]; other site 471853002945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853002946 DNA binding residues [nucleotide binding] 471853002947 dimerization interface [polypeptide binding]; other site 471853002948 Histidine kinase; Region: HisKA_3; pfam07730 471853002949 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853002950 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 471853002951 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 471853002952 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853002953 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853002954 Walker A/P-loop; other site 471853002955 ATP binding site [chemical binding]; other site 471853002956 Q-loop/lid; other site 471853002957 ABC transporter signature motif; other site 471853002958 Walker B; other site 471853002959 D-loop; other site 471853002960 H-loop/switch region; other site 471853002961 Bax inhibitor 1 like; Region: BaxI_1; cl17691 471853002962 cystathionine beta-synthase; Region: cysta_beta; TIGR01137 471853002963 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471853002964 dimer interface [polypeptide binding]; other site 471853002965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002966 catalytic residue [active] 471853002967 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream. The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609 471853002968 cystathionine gamma-synthase; Provisional; Region: PRK07811 471853002969 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471853002970 homodimer interface [polypeptide binding]; other site 471853002971 substrate-cofactor binding pocket; other site 471853002972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853002973 catalytic residue [active] 471853002974 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471853002975 putative hydrophobic ligand binding site [chemical binding]; other site 471853002976 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853002977 dimerization interface [polypeptide binding]; other site 471853002978 putative DNA binding site [nucleotide binding]; other site 471853002979 putative Zn2+ binding site [ion binding]; other site 471853002980 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 471853002981 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471853002982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853002983 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853002984 putative substrate translocation pore; other site 471853002985 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471853002986 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853002987 DinB superfamily; Region: DinB_2; pfam12867 471853002988 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 471853002989 putative hydrophobic ligand binding site [chemical binding]; other site 471853002990 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_8; cd08901 471853002991 putative hydrophobic ligand binding site [chemical binding]; other site 471853002992 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853002993 dimerization interface [polypeptide binding]; other site 471853002994 putative DNA binding site [nucleotide binding]; other site 471853002995 putative Zn2+ binding site [ion binding]; other site 471853002996 hypothetical protein; Provisional; Region: PRK07945 471853002997 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 471853002998 active site 471853002999 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 471853003000 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853003001 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853003002 active site 471853003003 metal binding site [ion binding]; metal-binding site 471853003004 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 471853003005 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 471853003006 Phosphotransferase enzyme family; Region: APH; pfam01636 471853003007 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471853003008 substrate binding site [chemical binding]; other site 471853003009 Protein of unknown function (DUF503); Region: DUF503; pfam04456 471853003010 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471853003011 TIGR03086 family protein; Region: TIGR03086 471853003012 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471853003013 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003014 NAD(P) binding site [chemical binding]; other site 471853003015 active site 471853003016 Predicted transcriptional regulators [Transcription]; Region: COG1733 471853003017 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471853003018 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 471853003019 threonine dehydratase; Provisional; Region: PRK08198 471853003020 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 471853003021 tetramer interface [polypeptide binding]; other site 471853003022 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003023 catalytic residue [active] 471853003024 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 471853003025 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 471853003026 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 471853003027 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 471853003028 Domain of unknown function (DUF4307); Region: DUF4307; pfam14155 471853003029 Predicted membrane protein [Function unknown]; Region: COG2311 471853003030 Protein of unknown function (DUF418); Region: DUF418; pfam04235 471853003031 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471853003032 preprotein translocase subunit SecY; Reviewed; Region: PRK08568 471853003033 Predicted amidohydrolase [General function prediction only]; Region: COG0388 471853003034 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 471853003035 active site 471853003036 catalytic triad [active] 471853003037 dimer interface [polypeptide binding]; other site 471853003038 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 471853003039 Haemolysin-III related; Region: HlyIII; pfam03006 471853003040 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 471853003041 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471853003042 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 471853003043 catalytic residue [active] 471853003044 putative FPP diphosphate binding site; other site 471853003045 putative FPP binding hydrophobic cleft; other site 471853003046 dimer interface [polypeptide binding]; other site 471853003047 putative IPP diphosphate binding site; other site 471853003048 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 471853003049 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 471853003050 putative active site [active] 471853003051 PhoH-like protein; Region: PhoH; pfam02562 471853003052 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 471853003053 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853003054 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853003055 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 471853003056 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471853003057 ferrochelatase; Reviewed; Region: hemH; PRK00035 471853003058 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 471853003059 C-terminal domain interface [polypeptide binding]; other site 471853003060 active site 471853003061 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 471853003062 active site 471853003063 N-terminal domain interface [polypeptide binding]; other site 471853003064 Predicted heme peroxidase involved in anaerobic stress response [General function prediction only]; Region: ywfI; COG3253 471853003065 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853003066 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853003067 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471853003068 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853003069 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 471853003070 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 471853003071 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 471853003072 active site clefts [active] 471853003073 zinc binding site [ion binding]; other site 471853003074 dimer interface [polypeptide binding]; other site 471853003075 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853003076 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853003077 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471853003078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003079 dimer interface [polypeptide binding]; other site 471853003080 conserved gate region; other site 471853003081 putative PBP binding loops; other site 471853003082 ABC-ATPase subunit interface; other site 471853003083 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853003084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003085 dimer interface [polypeptide binding]; other site 471853003086 conserved gate region; other site 471853003087 ABC-ATPase subunit interface; other site 471853003088 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471853003089 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 471853003090 Walker A/P-loop; other site 471853003091 ATP binding site [chemical binding]; other site 471853003092 Q-loop/lid; other site 471853003093 ABC transporter signature motif; other site 471853003094 Walker B; other site 471853003095 D-loop; other site 471853003096 H-loop/switch region; other site 471853003097 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853003098 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 471853003099 putative substrate binding site [chemical binding]; other site 471853003100 putative ATP binding site [chemical binding]; other site 471853003101 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 471853003102 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 471853003103 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 471853003104 generic binding surface II; other site 471853003105 generic binding surface I; other site 471853003106 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 471853003107 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 471853003108 RmuC family; Region: RmuC; pfam02646 471853003109 GTP-binding protein YchF; Reviewed; Region: PRK09601 471853003110 YchF GTPase; Region: YchF; cd01900 471853003111 G1 box; other site 471853003112 GTP/Mg2+ binding site [chemical binding]; other site 471853003113 Switch I region; other site 471853003114 G2 box; other site 471853003115 Switch II region; other site 471853003116 G3 box; other site 471853003117 G4 box; other site 471853003118 G5 box; other site 471853003119 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 471853003120 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 471853003121 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853003122 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853003123 active site 471853003124 metal binding site [ion binding]; metal-binding site 471853003125 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853003126 active site 471853003127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853003128 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 471853003129 heme-binding site [chemical binding]; other site 471853003130 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 471853003131 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853003132 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853003133 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853003134 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853003135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003136 ABC-ATPase subunit interface; other site 471853003137 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853003138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003139 dimer interface [polypeptide binding]; other site 471853003140 conserved gate region; other site 471853003141 putative PBP binding loops; other site 471853003142 ABC-ATPase subunit interface; other site 471853003143 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853003144 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853003145 Walker A/P-loop; other site 471853003146 ATP binding site [chemical binding]; other site 471853003147 Q-loop/lid; other site 471853003148 ABC transporter signature motif; other site 471853003149 Walker B; other site 471853003150 D-loop; other site 471853003151 H-loop/switch region; other site 471853003152 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853003153 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853003154 Walker A/P-loop; other site 471853003155 ATP binding site [chemical binding]; other site 471853003156 Q-loop/lid; other site 471853003157 ABC transporter signature motif; other site 471853003158 Walker B; other site 471853003159 D-loop; other site 471853003160 H-loop/switch region; other site 471853003161 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853003162 BCCT family transporter; Region: BCCT; pfam02028 471853003163 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 471853003164 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 471853003165 G1 box; other site 471853003166 putative GEF interaction site [polypeptide binding]; other site 471853003167 GTP/Mg2+ binding site [chemical binding]; other site 471853003168 Switch I region; other site 471853003169 G2 box; other site 471853003170 G3 box; other site 471853003171 Switch II region; other site 471853003172 G4 box; other site 471853003173 G5 box; other site 471853003174 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 471853003175 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 471853003176 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471853003177 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 471853003178 VanW like protein; Region: VanW; pfam04294 471853003179 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 471853003180 4Fe-4S binding domain; Region: Fer4; pfam00037 471853003181 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 471853003182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853003183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003184 homodimer interface [polypeptide binding]; other site 471853003185 catalytic residue [active] 471853003186 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 471853003187 dimer interface [polypeptide binding]; other site 471853003188 Citrate synthase; Region: Citrate_synt; pfam00285 471853003189 active site 471853003190 citrylCoA binding site [chemical binding]; other site 471853003191 NADH binding [chemical binding]; other site 471853003192 cationic pore residues; other site 471853003193 oxalacetate/citrate binding site [chemical binding]; other site 471853003194 coenzyme A binding site [chemical binding]; other site 471853003195 catalytic triad [active] 471853003196 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 471853003197 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471853003198 putative trimer interface [polypeptide binding]; other site 471853003199 putative CoA binding site [chemical binding]; other site 471853003200 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 471853003201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853003202 Cupin; Region: Cupin_6; pfam12852 471853003203 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853003204 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853003205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853003206 META domain; Region: META; pfam03724 471853003207 Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825 471853003208 NUDIX domain; Region: NUDIX; pfam00293 471853003209 nudix motif; other site 471853003210 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 471853003211 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471853003212 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 471853003213 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 471853003214 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471853003215 carboxyltransferase (CT) interaction site; other site 471853003216 biotinylation site [posttranslational modification]; other site 471853003217 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853003218 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853003219 active site 471853003220 metal binding site [ion binding]; metal-binding site 471853003221 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853003222 active site 471853003223 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853003224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853003225 Coenzyme A binding pocket [chemical binding]; other site 471853003226 Maf-like protein; Region: Maf; pfam02545 471853003227 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 471853003228 active site 471853003229 dimer interface [polypeptide binding]; other site 471853003230 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 471853003231 nudix motif; other site 471853003232 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853003233 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853003234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003235 NAD(P) binding site [chemical binding]; other site 471853003236 active site 471853003237 Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960 471853003238 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471853003239 conserved cys residue [active] 471853003240 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853003241 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853003242 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853003243 short chain dehydrogenase; Provisional; Region: PRK07577 471853003244 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003245 NAD(P) binding site [chemical binding]; other site 471853003246 active site 471853003247 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853003248 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 471853003249 substrate binding site [chemical binding]; other site 471853003250 dimer interface [polypeptide binding]; other site 471853003251 ATP binding site [chemical binding]; other site 471853003252 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471853003253 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 471853003254 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471853003255 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471853003256 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 471853003257 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 471853003258 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 471853003259 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 471853003260 cyclase homology domain; Region: CHD; cd07302 471853003261 nucleotidyl binding site; other site 471853003262 metal binding site [ion binding]; metal-binding site 471853003263 dimer interface [polypeptide binding]; other site 471853003264 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853003265 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853003266 active site 471853003267 phosphorylation site [posttranslational modification] 471853003268 intermolecular recognition site; other site 471853003269 dimerization interface [polypeptide binding]; other site 471853003270 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853003271 DNA binding site [nucleotide binding] 471853003272 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471853003273 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853003274 phosphorylation site [posttranslational modification] 471853003275 dimer interface [polypeptide binding]; other site 471853003276 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853003277 ATP binding site [chemical binding]; other site 471853003278 Mg2+ binding site [ion binding]; other site 471853003279 G-X-G motif; other site 471853003280 Predicted membrane protein [Function unknown]; Region: COG2246 471853003281 GtrA-like protein; Region: GtrA; pfam04138 471853003282 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 471853003283 ATP-grasp domain; Region: ATP-grasp; pfam02222 471853003284 AIR carboxylase; Region: AIRC; pfam00731 471853003285 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471853003286 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003287 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 471853003288 active site 471853003289 Beta-mannanase [Carbohydrate transport and metabolism]; Region: ManB; COG4124 471853003290 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 471853003291 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471853003292 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471853003293 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 471853003294 CoA binding domain; Region: CoA_binding; cl17356 471853003295 Transcriptional regulator [Transcription]; Region: LytR; COG1316 471853003296 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 471853003297 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471853003298 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853003299 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003300 NAD(P) binding site [chemical binding]; other site 471853003301 active site 471853003302 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471853003303 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003304 active site 471853003305 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003306 active site 471853003307 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471853003308 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471853003309 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 471853003310 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471853003311 UDP-galactopyranose mutase; Region: GLF; pfam03275 471853003312 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 471853003313 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 471853003314 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 471853003315 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 471853003316 active site 471853003317 metal-binding site 471853003318 LicD family; Region: LicD; pfam04991 471853003319 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 471853003320 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 471853003321 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 471853003322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003323 active site 471853003324 Stage II sporulation protein; Region: SpoIID; pfam08486 471853003325 Family description; Region: VCBS; pfam13517 471853003326 Family description; Region: VCBS; pfam13517 471853003327 Family description; Region: VCBS; pfam13517 471853003328 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471853003329 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471853003330 inhibitor-cofactor binding pocket; inhibition site 471853003331 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003332 catalytic residue [active] 471853003333 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853003334 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003335 NAD(P) binding site [chemical binding]; other site 471853003336 active site 471853003337 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 471853003338 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 471853003339 trimer interface [polypeptide binding]; other site 471853003340 active site 471853003341 substrate binding site [chemical binding]; other site 471853003342 CoA binding site [chemical binding]; other site 471853003343 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853003344 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853003345 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471853003346 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471853003347 inhibitor-cofactor binding pocket; inhibition site 471853003348 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003349 catalytic residue [active] 471853003350 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471853003351 putative trimer interface [polypeptide binding]; other site 471853003352 putative CoA binding site [chemical binding]; other site 471853003353 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 471853003354 hydroxyglutarate oxidase; Provisional; Region: PRK11728 471853003355 Predicted dehydrogenase [General function prediction only]; Region: COG0579 471853003356 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 471853003357 amidase catalytic site [active] 471853003358 Zn binding residues [ion binding]; other site 471853003359 substrate binding site [chemical binding]; other site 471853003360 Family description; Region: VCBS; pfam13517 471853003361 Family description; Region: VCBS; pfam13517 471853003362 Family description; Region: VCBS; pfam13517 471853003363 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 471853003364 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 471853003365 NAD binding site [chemical binding]; other site 471853003366 substrate binding site [chemical binding]; other site 471853003367 homodimer interface [polypeptide binding]; other site 471853003368 active site 471853003369 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 471853003370 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 471853003371 substrate binding site; other site 471853003372 tetramer interface; other site 471853003373 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 471853003374 trimer interface [polypeptide binding]; other site 471853003375 active site 471853003376 substrate binding site [chemical binding]; other site 471853003377 CoA binding site [chemical binding]; other site 471853003378 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853003379 active site 471853003380 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471853003381 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471853003382 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853003383 active site 471853003384 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471853003385 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471853003386 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 471853003387 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 471853003388 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 471853003389 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853003390 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853003391 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 471853003392 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 471853003393 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 471853003394 UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350 471853003395 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 471853003396 homodimer interface [polypeptide binding]; other site 471853003397 active site 471853003398 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471853003399 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853003400 active site 471853003401 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471853003402 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003403 NAD(P) binding site [chemical binding]; other site 471853003404 active site 471853003405 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 471853003406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 471853003407 active site 471853003408 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 471853003409 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 471853003410 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853003411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853003412 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471853003413 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853003414 S-adenosylmethionine binding site [chemical binding]; other site 471853003415 LicD family; Region: LicD; cl01378 471853003416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471853003417 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471853003418 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853003419 TIGR03089 family protein; Region: TIGR03089 471853003420 Transcription factor WhiB; Region: Whib; pfam02467 471853003421 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003422 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471853003423 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 471853003424 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 471853003425 NADP binding site [chemical binding]; other site 471853003426 active site 471853003427 putative substrate binding site [chemical binding]; other site 471853003428 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 471853003429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853003430 dimerization interface [polypeptide binding]; other site 471853003431 putative DNA binding site [nucleotide binding]; other site 471853003432 putative Zn2+ binding site [ion binding]; other site 471853003433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853003434 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 471853003435 Protein of unknown function (DUF3499); Region: DUF3499; pfam12005 471853003436 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471853003437 active site 471853003438 dimer interface [polypeptide binding]; other site 471853003439 motif 1; other site 471853003440 motif 2; other site 471853003441 motif 3; other site 471853003442 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 471853003443 anticodon binding site; other site 471853003444 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853003445 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853003446 active site 471853003447 catalytic site [active] 471853003448 Trm112p-like protein; Region: Trm112p; cl01066 471853003449 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 471853003450 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853003451 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 471853003452 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471853003453 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 471853003454 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 471853003455 Walker A/P-loop; other site 471853003456 ATP binding site [chemical binding]; other site 471853003457 Q-loop/lid; other site 471853003458 ABC transporter signature motif; other site 471853003459 Walker B; other site 471853003460 D-loop; other site 471853003461 H-loop/switch region; other site 471853003462 Cation efflux family; Region: Cation_efflux; pfam01545 471853003463 Cupin domain; Region: Cupin_2; pfam07883 471853003464 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471853003465 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853003466 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853003467 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471853003468 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471853003469 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 471853003470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003471 dimer interface [polypeptide binding]; other site 471853003472 conserved gate region; other site 471853003473 putative PBP binding loops; other site 471853003474 ABC-ATPase subunit interface; other site 471853003475 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 471853003476 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 471853003477 Walker A/P-loop; other site 471853003478 ATP binding site [chemical binding]; other site 471853003479 Q-loop/lid; other site 471853003480 ABC transporter signature motif; other site 471853003481 Walker B; other site 471853003482 D-loop; other site 471853003483 H-loop/switch region; other site 471853003484 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 471853003485 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471853003486 active site 471853003487 substrate binding site [chemical binding]; other site 471853003488 Phosphotransferase enzyme family; Region: APH; pfam01636 471853003489 ATP binding site [chemical binding]; other site 471853003490 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 471853003491 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 471853003492 dimer interface [polypeptide binding]; other site 471853003493 putative functional site; other site 471853003494 putative MPT binding site; other site 471853003495 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 471853003496 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853003497 DNA binding residues [nucleotide binding] 471853003498 TOBE domain; Region: TOBE; cl01440 471853003499 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 471853003500 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 471853003501 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003502 dimer interface [polypeptide binding]; other site 471853003503 conserved gate region; other site 471853003504 putative PBP binding loops; other site 471853003505 ABC-ATPase subunit interface; other site 471853003506 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 471853003507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853003508 Walker A/P-loop; other site 471853003509 ATP binding site [chemical binding]; other site 471853003510 Q-loop/lid; other site 471853003511 ABC transporter signature motif; other site 471853003512 Walker B; other site 471853003513 D-loop; other site 471853003514 H-loop/switch region; other site 471853003515 TOBE domain; Region: TOBE; cl01440 471853003516 Adenosylhomocysteinase; Provisional; Region: PTZ00075 471853003517 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 471853003518 homotetramer interface [polypeptide binding]; other site 471853003519 ligand binding site [chemical binding]; other site 471853003520 catalytic site [active] 471853003521 NAD binding site [chemical binding]; other site 471853003522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853003523 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853003524 Walker A/P-loop; other site 471853003525 ATP binding site [chemical binding]; other site 471853003526 Q-loop/lid; other site 471853003527 ABC transporter signature motif; other site 471853003528 Walker B; other site 471853003529 D-loop; other site 471853003530 H-loop/switch region; other site 471853003531 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471853003532 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 471853003533 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 471853003534 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853003535 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853003536 active site 471853003537 phosphorylation site [posttranslational modification] 471853003538 intermolecular recognition site; other site 471853003539 dimerization interface [polypeptide binding]; other site 471853003540 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853003541 DNA binding site [nucleotide binding] 471853003542 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471853003543 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471853003544 dimerization interface [polypeptide binding]; other site 471853003545 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853003546 dimer interface [polypeptide binding]; other site 471853003547 phosphorylation site [posttranslational modification] 471853003548 Histidine kinase-like ATPases; Region: HATPase_c; smart00387 471853003549 ATP binding site [chemical binding]; other site 471853003550 G-X-G motif; other site 471853003551 lipoprotein LpqB; Provisional; Region: PRK13614 471853003552 Sporulation and spore germination; Region: Germane; pfam10646 471853003553 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471853003554 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 471853003555 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 471853003556 30S subunit binding site; other site 471853003557 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 471853003558 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471853003559 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 471853003560 DEAD/DEAH box helicase; Region: DEAD; pfam00270 471853003561 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 471853003562 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 471853003563 nucleotide binding region [chemical binding]; other site 471853003564 AAA ATPase domain; Region: AAA_16; pfam13191 471853003565 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853003566 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853003567 DNA binding residues [nucleotide binding] 471853003568 dimerization interface [polypeptide binding]; other site 471853003569 AAA-like domain; Region: AAA_10; pfam12846 471853003570 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853003571 Walker A motif; other site 471853003572 ATP binding site [chemical binding]; other site 471853003573 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 471853003574 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331 471853003575 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 471853003576 putative ligand binding site [chemical binding]; other site 471853003577 DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005 471853003578 Ca binding site [ion binding]; other site 471853003579 carbohydrate binding site [chemical binding]; other site 471853003580 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471853003581 Helix-turn-helix domain; Region: HTH_17; pfam12728 471853003582 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 471853003583 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471853003584 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471853003585 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 471853003586 active site 471853003587 Predicted GTPases [General function prediction only]; Region: COG1162 471853003588 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471853003589 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471853003590 GTP/Mg2+ binding site [chemical binding]; other site 471853003591 G4 box; other site 471853003592 G5 box; other site 471853003593 G1 box; other site 471853003594 Switch I region; other site 471853003595 G2 box; other site 471853003596 G3 box; other site 471853003597 Switch II region; other site 471853003598 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 471853003599 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 471853003600 hinge; other site 471853003601 active site 471853003602 Predicted membrane protein [Function unknown]; Region: COG2259 471853003603 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 471853003604 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853003605 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853003606 DNA binding residues [nucleotide binding] 471853003607 mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806 471853003608 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 471853003609 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853003610 NAD(P) binding site [chemical binding]; other site 471853003611 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471853003612 active site 471853003613 catalytic triad [active] 471853003614 oxyanion hole [active] 471853003615 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 471853003616 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 471853003617 conserved cys residue [active] 471853003618 AAA ATPase domain; Region: AAA_16; pfam13191 471853003619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853003620 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853003621 DNA binding residues [nucleotide binding] 471853003622 dimerization interface [polypeptide binding]; other site 471853003623 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 471853003624 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471853003625 2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, and related enzymes [Energy production and conversion]; Region: SucA; COG0567 471853003626 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 471853003627 TPP-binding site [chemical binding]; other site 471853003628 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 471853003629 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471853003630 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471853003631 dimerization interface [polypeptide binding]; other site 471853003632 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853003633 dimer interface [polypeptide binding]; other site 471853003634 phosphorylation site [posttranslational modification] 471853003635 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853003636 Mg2+ binding site [ion binding]; other site 471853003637 G-X-G motif; other site 471853003638 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853003639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853003640 active site 471853003641 phosphorylation site [posttranslational modification] 471853003642 intermolecular recognition site; other site 471853003643 dimerization interface [polypeptide binding]; other site 471853003644 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853003645 DNA binding site [nucleotide binding] 471853003646 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471853003647 Peptidase family M23; Region: Peptidase_M23; pfam01551 471853003648 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 471853003649 active site 471853003650 catalytic residues [active] 471853003651 diaminopimelate decarboxylase; Region: lysA; TIGR01048 471853003652 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471853003653 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853003654 catalytic residue [active] 471853003655 homoserine dehydrogenase; Provisional; Region: PRK06349 471853003656 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 471853003657 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 471853003658 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 471853003659 threonine synthase; Reviewed; Region: PRK06721 471853003660 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 471853003661 homodimer interface [polypeptide binding]; other site 471853003662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853003663 catalytic residue [active] 471853003664 Homoserine kinase [Amino acid transport and metabolism]; Region: ThrB; COG0083 471853003665 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 471853003666 transcription termination factor Rho; Provisional; Region: PRK12608 471853003667 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471853003668 RNA binding site [nucleotide binding]; other site 471853003669 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471853003670 Walker A motif; other site 471853003671 ATP binding site [chemical binding]; other site 471853003672 Walker B motif; other site 471853003673 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 471853003674 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471853003675 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 471853003676 RF-1 domain; Region: RF-1; pfam00472 471853003677 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471853003678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853003679 S-adenosylmethionine binding site [chemical binding]; other site 471853003680 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 471853003681 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 471853003682 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 471853003683 Mg++ binding site [ion binding]; other site 471853003684 putative catalytic motif [active] 471853003685 substrate binding site [chemical binding]; other site 471853003686 The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563 471853003687 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 471853003688 active site 471853003689 PhoD-like phosphatase; Region: PhoD; pfam09423 471853003690 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853003691 putative active site [active] 471853003692 putative metal binding site [ion binding]; other site 471853003693 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853003694 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853003695 DNA binding site [nucleotide binding] 471853003696 domain linker motif; other site 471853003697 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853003698 ligand binding site [chemical binding]; other site 471853003699 dimerization interface [polypeptide binding]; other site 471853003700 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853003701 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853003702 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853003703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003704 dimer interface [polypeptide binding]; other site 471853003705 conserved gate region; other site 471853003706 putative PBP binding loops; other site 471853003707 ABC-ATPase subunit interface; other site 471853003708 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853003709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003710 dimer interface [polypeptide binding]; other site 471853003711 conserved gate region; other site 471853003712 putative PBP binding loops; other site 471853003713 ABC-ATPase subunit interface; other site 471853003714 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853003715 arylsulfatase; Provisional; Region: PRK13759 471853003716 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853003717 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 471853003718 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 471853003719 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 471853003720 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 471853003721 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 471853003722 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 471853003723 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 471853003724 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 471853003725 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471853003726 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 471853003727 beta subunit interaction interface [polypeptide binding]; other site 471853003728 Walker A motif; other site 471853003729 ATP binding site [chemical binding]; other site 471853003730 Walker B motif; other site 471853003731 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471853003732 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 471853003733 core domain interface [polypeptide binding]; other site 471853003734 delta subunit interface [polypeptide binding]; other site 471853003735 epsilon subunit interface [polypeptide binding]; other site 471853003736 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 471853003737 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 471853003738 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 471853003739 alpha subunit interaction interface [polypeptide binding]; other site 471853003740 Walker A motif; other site 471853003741 ATP binding site [chemical binding]; other site 471853003742 Walker B motif; other site 471853003743 inhibitor binding site; inhibition site 471853003744 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 471853003745 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 471853003746 gamma subunit interface [polypeptide binding]; other site 471853003747 LBP interface [polypeptide binding]; other site 471853003748 Protein of unknown function (DUF2550); Region: DUF2550; pfam10739 471853003749 hypothetical protein; Provisional; Region: PRK03298 471853003750 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853003751 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853003752 Domain of unknown function (DUF1990); Region: DUF1990; cl01969 471853003753 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 471853003754 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853003755 active site 471853003756 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853003757 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471853003758 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471853003759 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 471853003760 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853003761 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853003762 DNA binding site [nucleotide binding] 471853003763 domain linker motif; other site 471853003764 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853003765 dimerization interface [polypeptide binding]; other site 471853003766 ligand binding site [chemical binding]; other site 471853003767 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853003768 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471853003769 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471853003770 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471853003771 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 471853003772 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853003773 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853003774 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003775 dimer interface [polypeptide binding]; other site 471853003776 conserved gate region; other site 471853003777 ABC-ATPase subunit interface; other site 471853003778 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853003779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003780 dimer interface [polypeptide binding]; other site 471853003781 conserved gate region; other site 471853003782 putative PBP binding loops; other site 471853003783 ABC-ATPase subunit interface; other site 471853003784 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853003785 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853003786 DNA binding site [nucleotide binding] 471853003787 domain linker motif; other site 471853003788 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853003789 dimerization interface [polypeptide binding]; other site 471853003790 ligand binding site [chemical binding]; other site 471853003791 putative alpha-glucosidase; Provisional; Region: PRK10658 471853003792 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 471853003793 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 471853003794 active site 471853003795 homotrimer interface [polypeptide binding]; other site 471853003796 catalytic site [active] 471853003797 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 471853003798 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853003799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853003800 Walker A/P-loop; other site 471853003801 ATP binding site [chemical binding]; other site 471853003802 Q-loop/lid; other site 471853003803 ABC transporter signature motif; other site 471853003804 Walker B; other site 471853003805 D-loop; other site 471853003806 H-loop/switch region; other site 471853003807 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853003808 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471853003809 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853003810 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 471853003811 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 471853003812 glycogen branching enzyme; Provisional; Region: PRK05402 471853003813 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 471853003814 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 471853003815 active site 471853003816 catalytic site [active] 471853003817 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 471853003818 trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457 471853003819 Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281 471853003820 trehalose synthase; Region: treS_nterm; TIGR02456 471853003821 Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334 471853003822 active site 471853003823 catalytic site [active] 471853003824 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 471853003825 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 471853003826 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471853003827 active site 471853003828 homodimer interface [polypeptide binding]; other site 471853003829 catalytic site [active] 471853003830 acceptor binding site [chemical binding]; other site 471853003831 This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299 471853003832 putative homodimer interface [polypeptide binding]; other site 471853003833 putative active site pocket [active] 471853003834 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 471853003835 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853003836 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471853003837 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471853003838 active site 471853003839 HIGH motif; other site 471853003840 dimer interface [polypeptide binding]; other site 471853003841 KMSKS motif; other site 471853003842 RDD family; Region: RDD; pfam06271 471853003843 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 471853003844 FAD binding domain; Region: FAD_binding_2; pfam00890 471853003845 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 471853003846 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 471853003847 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 471853003848 active site 471853003849 catalytic site [active] 471853003850 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 471853003851 Ligand binding site [chemical binding]; other site 471853003852 Electron transfer flavoprotein domain; Region: ETF; pfam01012 471853003853 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 471853003854 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 471853003855 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853003856 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853003857 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853003858 putative active site [active] 471853003859 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853003860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853003861 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 471853003862 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471853003863 Walker A/P-loop; other site 471853003864 ATP binding site [chemical binding]; other site 471853003865 Q-loop/lid; other site 471853003866 ABC transporter signature motif; other site 471853003867 Walker B; other site 471853003868 D-loop; other site 471853003869 H-loop/switch region; other site 471853003870 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471853003871 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471853003872 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471853003873 TM-ABC transporter signature motif; other site 471853003874 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853003875 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 471853003876 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853003877 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853003878 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853003879 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471853003880 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471853003881 Metal-binding active site; metal-binding site 471853003882 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 471853003883 Phosphotransferase enzyme family; Region: APH; pfam01636 471853003884 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853003885 active site 471853003886 ATP binding site [chemical binding]; other site 471853003887 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853003888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 471853003889 active site 471853003890 phosphorylation site [posttranslational modification] 471853003891 intermolecular recognition site; other site 471853003892 dimerization interface [polypeptide binding]; other site 471853003893 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853003894 DNA binding residues [nucleotide binding] 471853003895 Putative sensor; Region: Sensor; pfam13796 471853003896 Histidine kinase; Region: HisKA_3; pfam07730 471853003897 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853003898 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853003899 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471853003900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853003901 catalytic residue [active] 471853003902 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853003903 NAD(P) binding site [chemical binding]; other site 471853003904 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853003905 active site 471853003906 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 471853003907 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 471853003908 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 471853003909 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471853003910 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 471853003911 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853003912 putative substrate translocation pore; other site 471853003913 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853003914 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853003915 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853003916 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 471853003917 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 471853003918 nucleotide binding pocket [chemical binding]; other site 471853003919 K-X-D-G motif; other site 471853003920 catalytic site [active] 471853003921 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 471853003922 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 471853003923 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 471853003924 Dimer interface [polypeptide binding]; other site 471853003925 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 471853003926 putative active site [active] 471853003927 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 471853003928 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 471853003929 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471853003930 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471853003931 glycosyltransferase, MGT family; Region: MGT; TIGR01426 471853003932 active site 471853003933 TDP-binding site; other site 471853003934 acceptor substrate-binding pocket; other site 471853003935 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853003936 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853003937 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 471853003938 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471853003939 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 471853003940 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 471853003941 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 471853003942 GatB domain; Region: GatB_Yqey; smart00845 471853003943 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853003944 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853003945 Coenzyme A binding pocket [chemical binding]; other site 471853003946 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 471853003947 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 471853003948 metal binding site [ion binding]; metal-binding site 471853003949 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471853003950 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471853003951 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471853003952 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471853003953 ABC-ATPase subunit interface; other site 471853003954 dimer interface [polypeptide binding]; other site 471853003955 putative PBP binding regions; other site 471853003956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853003957 putative DNA binding site [nucleotide binding]; other site 471853003958 putative Zn2+ binding site [ion binding]; other site 471853003959 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 471853003960 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 471853003961 FeoA domain; Region: FeoA; pfam04023 471853003962 Protein of unknown function (DUF1343); Region: DUF1343; pfam07075 471853003963 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853003964 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853003965 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853003966 putative active site [active] 471853003967 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 471853003968 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853003969 Coenzyme A binding pocket [chemical binding]; other site 471853003970 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853003971 substrate binding site [chemical binding]; other site 471853003972 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853003973 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853003974 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853003975 substrate binding site [chemical binding]; other site 471853003976 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853003977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003978 dimer interface [polypeptide binding]; other site 471853003979 conserved gate region; other site 471853003980 putative PBP binding loops; other site 471853003981 ABC-ATPase subunit interface; other site 471853003982 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853003983 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471853003984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853003985 dimer interface [polypeptide binding]; other site 471853003986 conserved gate region; other site 471853003987 putative PBP binding loops; other site 471853003988 ABC-ATPase subunit interface; other site 471853003989 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471853003990 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853003991 Walker A/P-loop; other site 471853003992 ATP binding site [chemical binding]; other site 471853003993 Q-loop/lid; other site 471853003994 ABC transporter signature motif; other site 471853003995 Walker B; other site 471853003996 D-loop; other site 471853003997 H-loop/switch region; other site 471853003998 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853003999 nickel import ATP-binding protein NikD; Region: nickel_nikD; TIGR02770 471853004000 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853004001 Walker A/P-loop; other site 471853004002 ATP binding site [chemical binding]; other site 471853004003 Q-loop/lid; other site 471853004004 ABC transporter signature motif; other site 471853004005 Walker B; other site 471853004006 D-loop; other site 471853004007 H-loop/switch region; other site 471853004008 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853004009 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471853004010 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853004011 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 471853004012 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 471853004013 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 471853004014 aromatic arch; other site 471853004015 DCoH dimer interaction site [polypeptide binding]; other site 471853004016 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471853004017 DCoH tetramer interaction site [polypeptide binding]; other site 471853004018 substrate binding site [chemical binding]; other site 471853004019 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 471853004020 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 471853004021 PYR/PP interface [polypeptide binding]; other site 471853004022 dimer interface [polypeptide binding]; other site 471853004023 TPP binding site [chemical binding]; other site 471853004024 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 471853004025 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 471853004026 TPP-binding site [chemical binding]; other site 471853004027 dimer interface [polypeptide binding]; other site 471853004028 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 471853004029 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 471853004030 putative valine binding site [chemical binding]; other site 471853004031 dimer interface [polypeptide binding]; other site 471853004032 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 471853004033 ketol-acid reductoisomerase; Provisional; Region: PRK05479 471853004034 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 471853004035 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 471853004036 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471853004037 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 471853004038 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471853004039 minor groove reading motif; other site 471853004040 helix-hairpin-helix signature motif; other site 471853004041 substrate binding pocket [chemical binding]; other site 471853004042 active site 471853004043 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 471853004044 active site 471853004045 catalytic residues [active] 471853004046 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471853004047 Strictosidine synthase; Region: Str_synth; pfam03088 471853004048 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 471853004049 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 471853004050 tartrate dehydrogenase; Region: TTC; TIGR02089 471853004051 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 471853004052 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 471853004053 homodimer interface [polypeptide binding]; other site 471853004054 substrate-cofactor binding pocket; other site 471853004055 catalytic residue [active] 471853004056 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471853004057 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004058 mycofactocin system transcriptional regulator; Region: mycofact_TetR; TIGR03968 471853004059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853004060 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 471853004061 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 471853004062 active site 471853004063 catalytic residues [active] 471853004064 metal binding site [ion binding]; metal-binding site 471853004065 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 471853004066 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 471853004067 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853004068 non-specific DNA binding site [nucleotide binding]; other site 471853004069 salt bridge; other site 471853004070 sequence-specific DNA binding site [nucleotide binding]; other site 471853004071 Cupin domain; Region: Cupin_2; pfam07883 471853004072 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 471853004073 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853004074 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 471853004075 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 471853004076 minor groove reading motif; other site 471853004077 helix-hairpin-helix signature motif; other site 471853004078 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853004079 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 471853004080 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853004081 catalytic residue [active] 471853004082 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 471853004083 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853004084 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853004085 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853004086 DNA-binding site [nucleotide binding]; DNA binding site 471853004087 FCD domain; Region: FCD; pfam07729 471853004088 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853004089 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853004090 inhibitor site; inhibition site 471853004091 active site 471853004092 dimer interface [polypeptide binding]; other site 471853004093 catalytic residue [active] 471853004094 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471853004095 catalytic site [active] 471853004096 BNR repeat-like domain; Region: BNR_2; pfam13088 471853004097 Asp-box motif; other site 471853004098 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004099 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004101 dimer interface [polypeptide binding]; other site 471853004102 conserved gate region; other site 471853004103 ABC-ATPase subunit interface; other site 471853004104 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004105 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004106 dimer interface [polypeptide binding]; other site 471853004107 conserved gate region; other site 471853004108 putative PBP binding loops; other site 471853004109 ABC-ATPase subunit interface; other site 471853004110 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 471853004111 catalytic site [active] 471853004112 BNR repeat-like domain; Region: BNR_2; pfam13088 471853004113 Asp-box motif; other site 471853004114 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 471853004115 putative deacylase active site [active] 471853004116 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 471853004117 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 471853004118 DEAD/DEAH box helicase; Region: DEAD; pfam00270 471853004119 ATP binding site [chemical binding]; other site 471853004120 putative Mg++ binding site [ion binding]; other site 471853004121 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853004122 nucleotide binding region [chemical binding]; other site 471853004123 ATP-binding site [chemical binding]; other site 471853004124 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 471853004125 Helix-turn-helix domain; Region: HTH_17; pfam12728 471853004126 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 471853004127 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 471853004128 23S rRNA methyluridine methyltransferase; Reviewed; Region: rumB; PRK03522 471853004129 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471853004130 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853004131 DNA-binding site [nucleotide binding]; DNA binding site 471853004132 FCD domain; Region: FCD; pfam07729 471853004133 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471853004134 nucleoside/Zn binding site; other site 471853004135 dimer interface [polypeptide binding]; other site 471853004136 catalytic motif [active] 471853004137 cytosine deaminase; Provisional; Region: PRK05985 471853004138 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 471853004139 active site 471853004140 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471853004141 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 471853004142 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004143 NAD(P) binding site [chemical binding]; other site 471853004144 active site 471853004145 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004146 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853004147 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004148 dimer interface [polypeptide binding]; other site 471853004149 conserved gate region; other site 471853004150 putative PBP binding loops; other site 471853004151 ABC-ATPase subunit interface; other site 471853004152 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004154 dimer interface [polypeptide binding]; other site 471853004155 conserved gate region; other site 471853004156 ABC-ATPase subunit interface; other site 471853004157 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853004158 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471853004159 Glutamate-1-semialdehyde aminotransferase [Coenzyme metabolism]; Region: HemL; COG0001 471853004160 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471853004161 inhibitor-cofactor binding pocket; inhibition site 471853004162 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853004163 catalytic residue [active] 471853004164 Uncharacterized conserved protein [Function unknown]; Region: COG5476 471853004165 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 471853004166 MlrC C-terminus; Region: MlrC_C; pfam07171 471853004167 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853004168 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853004169 active site pocket [active] 471853004170 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853004171 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 471853004172 active site 471853004173 metal binding site [ion binding]; metal-binding site 471853004174 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 471853004175 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471853004176 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853004177 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853004178 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853004179 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 471853004180 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853004181 ATP binding site [chemical binding]; other site 471853004182 putative Mg++ binding site [ion binding]; other site 471853004183 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853004184 nucleotide binding region [chemical binding]; other site 471853004185 ATP-binding site [chemical binding]; other site 471853004186 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853004187 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853004188 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004189 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853004190 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004192 putative PBP binding loops; other site 471853004193 dimer interface [polypeptide binding]; other site 471853004194 ABC-ATPase subunit interface; other site 471853004195 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004197 dimer interface [polypeptide binding]; other site 471853004198 conserved gate region; other site 471853004199 putative PBP binding loops; other site 471853004200 ABC-ATPase subunit interface; other site 471853004201 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 471853004202 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 471853004203 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004204 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004205 DNA binding site [nucleotide binding] 471853004206 domain linker motif; other site 471853004207 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853004208 ligand binding site [chemical binding]; other site 471853004209 dimerization interface [polypeptide binding]; other site 471853004210 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471853004211 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471853004212 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471853004213 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 471853004214 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 471853004215 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like_2; cd11339 471853004216 active site 471853004217 catalytic site [active] 471853004218 putative hydrolase, CocE/NonD family; Region: /NonD; TIGR00976 471853004219 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 471853004220 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004221 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004222 putative PBP binding loops; other site 471853004223 dimer interface [polypeptide binding]; other site 471853004224 ABC-ATPase subunit interface; other site 471853004225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004226 dimer interface [polypeptide binding]; other site 471853004227 conserved gate region; other site 471853004228 putative PBP binding loops; other site 471853004229 ABC-ATPase subunit interface; other site 471853004230 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 471853004231 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853004232 short chain dehydrogenase; Provisional; Region: PRK06138 471853004233 classical (c) SDRs; Region: SDR_c; cd05233 471853004234 NAD(P) binding site [chemical binding]; other site 471853004235 active site 471853004236 enolase; Provisional; Region: eno; PRK00077 471853004237 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471853004238 metal binding site [ion binding]; metal-binding site 471853004239 substrate binding pocket [chemical binding]; other site 471853004240 Phosphotransferase enzyme family; Region: APH; pfam01636 471853004241 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 471853004242 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471853004243 substrate binding site [chemical binding]; other site 471853004244 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853004245 (2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233 471853004246 putative NAD(P) binding site [chemical binding]; other site 471853004247 catalytic Zn binding site [ion binding]; other site 471853004248 Dehydratase family; Region: ILVD_EDD; pfam00920 471853004249 MarR family; Region: MarR_2; pfam12802 471853004250 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853004251 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853004252 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471853004253 nucleotide binding site [chemical binding]; other site 471853004254 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471853004255 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853004256 Protein of unknown function DUF91; Region: DUF91; cl00709 471853004257 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 471853004258 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471853004259 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853004260 S-adenosylmethionine binding site [chemical binding]; other site 471853004261 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853004262 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471853004263 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853004264 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471853004265 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471853004266 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853004267 ATP binding site [chemical binding]; other site 471853004268 putative Mg++ binding site [ion binding]; other site 471853004269 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 471853004270 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471853004271 nucleotide binding site/active site [active] 471853004272 HIT family signature motif; other site 471853004273 catalytic residue [active] 471853004274 Protein of unknown function DUF262; Region: DUF262; pfam03235 471853004275 Uncharacterized conserved protein [Function unknown]; Region: COG1479 471853004276 Protein of unknown function DUF262; Region: DUF262; pfam03235 471853004277 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 471853004278 Right handed beta helix region; Region: Beta_helix; pfam13229 471853004279 PhoD-like phosphatase; Region: PhoD; pfam09423 471853004280 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853004281 putative active site [active] 471853004282 putative metal binding site [ion binding]; other site 471853004283 Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175 471853004284 active site 471853004285 metal binding site [ion binding]; metal-binding site 471853004286 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 471853004287 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 471853004288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853004289 active site 471853004290 motif I; other site 471853004291 motif II; other site 471853004292 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853004293 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 471853004294 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004295 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004296 dimer interface [polypeptide binding]; other site 471853004297 putative PBP binding loops; other site 471853004298 ABC-ATPase subunit interface; other site 471853004299 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004301 dimer interface [polypeptide binding]; other site 471853004302 conserved gate region; other site 471853004303 putative PBP binding loops; other site 471853004304 ABC-ATPase subunit interface; other site 471853004305 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853004306 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853004307 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853004308 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471853004309 active site 471853004310 catalytic site [active] 471853004311 Carbohydrate kinase and ribulose-phosphate 3-epimerase fusion proteins-like; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CarbK-RPE_like; cd07783 471853004312 Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069 471853004313 N- and C-terminal domain interface [polypeptide binding]; other site 471853004314 active site 471853004315 MgATP binding site [chemical binding]; other site 471853004316 catalytic site [active] 471853004317 metal binding site [ion binding]; metal-binding site 471853004318 putative carbohydrate binding site [chemical binding]; other site 471853004319 putative homodimer interface [polypeptide binding]; other site 471853004320 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 471853004321 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 471853004322 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471853004323 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853004324 inhibitor site; inhibition site 471853004325 active site 471853004326 dimer interface [polypeptide binding]; other site 471853004327 catalytic residue [active] 471853004328 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 471853004329 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004330 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004332 dimer interface [polypeptide binding]; other site 471853004333 conserved gate region; other site 471853004334 putative PBP binding loops; other site 471853004335 ABC-ATPase subunit interface; other site 471853004336 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004338 dimer interface [polypeptide binding]; other site 471853004339 conserved gate region; other site 471853004340 putative PBP binding loops; other site 471853004341 ABC-ATPase subunit interface; other site 471853004342 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471853004343 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853004344 DNA-binding site [nucleotide binding]; DNA binding site 471853004345 FCD domain; Region: FCD; pfam07729 471853004346 MarR family; Region: MarR; pfam01047 471853004347 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004348 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004349 DNA binding site [nucleotide binding] 471853004350 domain linker motif; other site 471853004351 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853004352 dimerization interface [polypeptide binding]; other site 471853004353 ligand binding site [chemical binding]; other site 471853004354 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853004355 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004356 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853004357 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 471853004358 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004360 dimer interface [polypeptide binding]; other site 471853004361 conserved gate region; other site 471853004362 putative PBP binding loops; other site 471853004363 ABC-ATPase subunit interface; other site 471853004364 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853004365 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 471853004366 Walker A/P-loop; other site 471853004367 ATP binding site [chemical binding]; other site 471853004368 Q-loop/lid; other site 471853004369 ABC transporter signature motif; other site 471853004370 Walker B; other site 471853004371 D-loop; other site 471853004372 H-loop/switch region; other site 471853004373 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853004374 Q-loop/lid; other site 471853004375 ABC transporter signature motif; other site 471853004376 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471853004377 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 471853004378 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004379 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853004380 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004382 dimer interface [polypeptide binding]; other site 471853004383 conserved gate region; other site 471853004384 putative PBP binding loops; other site 471853004385 ABC-ATPase subunit interface; other site 471853004386 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004387 dimer interface [polypeptide binding]; other site 471853004388 conserved gate region; other site 471853004389 putative PBP binding loops; other site 471853004390 ABC-ATPase subunit interface; other site 471853004391 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853004392 putative metal binding site [ion binding]; other site 471853004393 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar3; cd08577 471853004394 putative active site [active] 471853004395 catalytic site [active] 471853004396 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853004397 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004398 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004399 dimer interface [polypeptide binding]; other site 471853004400 conserved gate region; other site 471853004401 putative PBP binding loops; other site 471853004402 ABC-ATPase subunit interface; other site 471853004403 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853004404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004405 dimer interface [polypeptide binding]; other site 471853004406 putative PBP binding loops; other site 471853004407 ABC-ATPase subunit interface; other site 471853004408 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853004409 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853004410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004412 DNA binding site [nucleotide binding] 471853004413 domain linker motif; other site 471853004414 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853004415 dimerization interface [polypeptide binding]; other site 471853004416 ligand binding site [chemical binding]; other site 471853004417 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853004418 non-specific DNA binding site [nucleotide binding]; other site 471853004419 salt bridge; other site 471853004420 sequence-specific DNA binding site [nucleotide binding]; other site 471853004421 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853004422 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853004423 active site 471853004424 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471853004425 nudix motif; other site 471853004426 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471853004427 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853004428 DNA-binding site [nucleotide binding]; DNA binding site 471853004429 FCD domain; Region: FCD; pfam07729 471853004430 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 471853004431 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853004432 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853004433 active site 471853004434 catalytic tetrad [active] 471853004435 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004436 dimer interface [polypeptide binding]; other site 471853004437 conserved gate region; other site 471853004438 putative PBP binding loops; other site 471853004439 ABC-ATPase subunit interface; other site 471853004440 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004442 dimer interface [polypeptide binding]; other site 471853004443 conserved gate region; other site 471853004444 putative PBP binding loops; other site 471853004445 ABC-ATPase subunit interface; other site 471853004446 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853004447 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 471853004448 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853004449 NAD(P) binding site [chemical binding]; other site 471853004450 active site 471853004451 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK09260 471853004452 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471853004453 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471853004454 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471853004455 dihydroxyacetone kinase; Provisional; Region: PRK14479 471853004456 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 471853004457 DAK2 domain; Region: Dak2; pfam02734 471853004458 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 471853004459 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471853004460 substrate binding site [chemical binding]; other site 471853004461 dimer interface [polypeptide binding]; other site 471853004462 triosephosphate isomerase; Provisional; Region: PRK14565 471853004463 catalytic triad [active] 471853004464 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471853004465 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 471853004466 active site 471853004467 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853004468 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471853004469 YCII-related domain; Region: YCII; cl00999 471853004470 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853004471 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853004472 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471853004473 Walker A/P-loop; other site 471853004474 ATP binding site [chemical binding]; other site 471853004475 Q-loop/lid; other site 471853004476 ABC transporter signature motif; other site 471853004477 Walker B; other site 471853004478 D-loop; other site 471853004479 H-loop/switch region; other site 471853004480 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853004481 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471853004482 Walker A/P-loop; other site 471853004483 ATP binding site [chemical binding]; other site 471853004484 Q-loop/lid; other site 471853004485 ABC transporter signature motif; other site 471853004486 Walker B; other site 471853004487 D-loop; other site 471853004488 H-loop/switch region; other site 471853004489 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471853004490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853004491 S-adenosylmethionine binding site [chemical binding]; other site 471853004492 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853004493 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853004494 DNA binding residues [nucleotide binding] 471853004495 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853004496 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853004497 DNA binding residues [nucleotide binding] 471853004498 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 471853004499 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471853004500 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471853004501 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 471853004502 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471853004503 HIGH motif; other site 471853004504 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 471853004505 active site 471853004506 KMSKS motif; other site 471853004507 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471853004508 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853004509 motif II; other site 471853004510 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853004511 Coenzyme A binding pocket [chemical binding]; other site 471853004512 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471853004513 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 471853004514 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471853004515 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 471853004516 Family description; Region: UvrD_C_2; pfam13538 471853004517 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471853004518 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471853004519 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853004520 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853004521 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 471853004522 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 471853004523 substrate binding site [chemical binding]; other site 471853004524 ligand binding site [chemical binding]; other site 471853004525 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 471853004526 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 471853004527 substrate binding site [chemical binding]; other site 471853004528 Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088 471853004529 alpha-amylase; Reviewed; Region: malS; PRK09505 471853004530 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853004531 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853004532 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853004533 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004534 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004535 DNA binding site [nucleotide binding] 471853004536 domain linker motif; other site 471853004537 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853004538 dimerization interface [polypeptide binding]; other site 471853004539 ligand binding site [chemical binding]; other site 471853004540 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004541 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004543 dimer interface [polypeptide binding]; other site 471853004544 conserved gate region; other site 471853004545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853004546 ABC-ATPase subunit interface; other site 471853004547 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004548 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 471853004549 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471853004550 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004551 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853004552 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853004553 Walker A/P-loop; other site 471853004554 ATP binding site [chemical binding]; other site 471853004555 Q-loop/lid; other site 471853004556 ABC transporter signature motif; other site 471853004557 Walker B; other site 471853004558 D-loop; other site 471853004559 H-loop/switch region; other site 471853004560 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853004561 Histidine kinase; Region: HisKA_3; pfam07730 471853004562 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853004563 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853004564 active site 471853004565 phosphorylation site [posttranslational modification] 471853004566 intermolecular recognition site; other site 471853004567 dimerization interface [polypeptide binding]; other site 471853004568 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853004569 DNA binding residues [nucleotide binding] 471853004570 dimerization interface [polypeptide binding]; other site 471853004571 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471853004572 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471853004573 putative acyl-acceptor binding pocket; other site 471853004574 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 471853004575 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 471853004576 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 471853004577 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471853004578 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 471853004579 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853004580 Protein of unknown function (DUF2804); Region: DUF2804; pfam10974 471853004581 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853004582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853004583 putative substrate translocation pore; other site 471853004584 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 471853004585 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853004586 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853004587 catalytic residue [active] 471853004588 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 471853004589 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471853004590 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 471853004591 Protein of unknown function (DUF3515); Region: DUF3515; pfam12028 471853004592 thiamine monophosphate kinase; Provisional; Region: PRK05731 471853004593 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 471853004594 ATP binding site [chemical binding]; other site 471853004595 dimerization interface [polypeptide binding]; other site 471853004596 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471853004597 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853004598 Coenzyme A binding pocket [chemical binding]; other site 471853004599 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 471853004600 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 471853004601 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471853004602 ssDNA binding site; other site 471853004603 generic binding surface II; other site 471853004604 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853004605 ATP binding site [chemical binding]; other site 471853004606 putative Mg++ binding site [ion binding]; other site 471853004607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853004608 nucleotide binding region [chemical binding]; other site 471853004609 ATP-binding site [chemical binding]; other site 471853004610 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853004611 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853004612 Walker A/P-loop; other site 471853004613 ATP binding site [chemical binding]; other site 471853004614 Q-loop/lid; other site 471853004615 ABC transporter signature motif; other site 471853004616 Walker B; other site 471853004617 D-loop; other site 471853004618 H-loop/switch region; other site 471853004619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853004620 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853004621 putative substrate translocation pore; other site 471853004622 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 471853004623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853004624 S-adenosylmethionine binding site [chemical binding]; other site 471853004625 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 471853004626 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 471853004627 active site 471853004628 (T/H)XGH motif; other site 471853004629 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 471853004630 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 471853004631 ribonuclease III; Reviewed; Region: rnc; PRK00102 471853004632 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 471853004633 dimerization interface [polypeptide binding]; other site 471853004634 active site 471853004635 metal binding site [ion binding]; metal-binding site 471853004636 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 471853004637 dsRNA binding site [nucleotide binding]; other site 471853004638 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 471853004639 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 471853004640 DNA binding site [nucleotide binding] 471853004641 catalytic residue [active] 471853004642 H2TH interface [polypeptide binding]; other site 471853004643 putative catalytic residues [active] 471853004644 turnover-facilitating residue; other site 471853004645 intercalation triad [nucleotide binding]; other site 471853004646 8OG recognition residue [nucleotide binding]; other site 471853004647 putative reading head residues; other site 471853004648 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471853004649 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471853004650 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853004651 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853004652 active site 471853004653 phosphorylation site [posttranslational modification] 471853004654 intermolecular recognition site; other site 471853004655 dimerization interface [polypeptide binding]; other site 471853004656 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853004657 DNA binding residues [nucleotide binding] 471853004658 dimerization interface [polypeptide binding]; other site 471853004659 BLMT, a bleomycin resistance protein encoded on the transposon Tn5, and similar proteins; Region: BLMT_like; cd08350 471853004660 dimer interface [polypeptide binding]; other site 471853004661 ligand binding site [chemical binding]; other site 471853004662 GAF domain; Region: GAF; pfam01590 471853004663 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853004664 Histidine kinase; Region: HisKA_3; pfam07730 471853004665 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 471853004666 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 471853004667 Walker A/P-loop; other site 471853004668 ATP binding site [chemical binding]; other site 471853004669 Q-loop/lid; other site 471853004670 ABC transporter signature motif; other site 471853004671 Walker B; other site 471853004672 D-loop; other site 471853004673 H-loop/switch region; other site 471853004674 thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857 471853004675 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853004676 Walker A/P-loop; other site 471853004677 ATP binding site [chemical binding]; other site 471853004678 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 471853004679 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 471853004680 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 471853004681 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 471853004682 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 471853004683 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 471853004684 homodimer interface [polypeptide binding]; other site 471853004685 oligonucleotide binding site [chemical binding]; other site 471853004686 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 471853004687 active site pocket [active] 471853004688 oxyanion hole [active] 471853004689 catalytic triad [active] 471853004690 active site nucleophile [active] 471853004691 Dodecin; Region: Dodecin; pfam07311 471853004692 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 471853004693 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 471853004694 GTPase CgtA; Reviewed; Region: obgE; PRK12296 471853004695 GTP1/OBG; Region: GTP1_OBG; pfam01018 471853004696 Obg GTPase; Region: Obg; cd01898 471853004697 G1 box; other site 471853004698 GTP/Mg2+ binding site [chemical binding]; other site 471853004699 Switch I region; other site 471853004700 G2 box; other site 471853004701 G3 box; other site 471853004702 Switch II region; other site 471853004703 G4 box; other site 471853004704 G5 box; other site 471853004705 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 471853004706 gamma-glutamyl kinase; Provisional; Region: PRK05429 471853004707 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 471853004708 nucleotide binding site [chemical binding]; other site 471853004709 homotetrameric interface [polypeptide binding]; other site 471853004710 putative phosphate binding site [ion binding]; other site 471853004711 putative allosteric binding site; other site 471853004712 PUA domain; Region: PUA; pfam01472 471853004713 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471853004714 substrate binding site [chemical binding]; other site 471853004715 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853004716 ATP binding site [chemical binding]; other site 471853004717 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 471853004718 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 471853004719 active site 471853004720 intersubunit interface [polypeptide binding]; other site 471853004721 catalytic residue [active] 471853004722 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004723 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471853004724 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853004725 DNA binding residues [nucleotide binding] 471853004726 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 471853004727 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471853004728 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853004729 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 471853004730 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 471853004731 active site 471853004732 (T/H)XGH motif; other site 471853004733 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 471853004734 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853004735 active site 471853004736 catalytic site [active] 471853004737 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 471853004738 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853004739 catalytic core [active] 471853004740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853004741 S-adenosylmethionine binding site [chemical binding]; other site 471853004742 ZIP Zinc transporter; Region: Zip; pfam02535 471853004743 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 471853004744 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 471853004745 active site 471853004746 DNA binding site [nucleotide binding] 471853004747 Int/Topo IB signature motif; other site 471853004748 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853004749 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 471853004750 dimer interface [polypeptide binding]; other site 471853004751 Lsr2; Region: Lsr2; pfam11774 471853004752 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 471853004753 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853004754 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 471853004755 active site 471853004756 metal binding site [ion binding]; metal-binding site 471853004757 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 471853004758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 471853004759 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853004760 dimerization interface [polypeptide binding]; other site 471853004761 Lysine efflux permease [General function prediction only]; Region: COG1279 471853004762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853004763 S-adenosylmethionine binding site [chemical binding]; other site 471853004764 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 471853004765 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853004766 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853004767 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853004768 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004769 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853004770 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004772 putative PBP binding loops; other site 471853004773 ABC-ATPase subunit interface; other site 471853004774 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004775 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004776 dimer interface [polypeptide binding]; other site 471853004777 conserved gate region; other site 471853004778 putative PBP binding loops; other site 471853004779 ABC-ATPase subunit interface; other site 471853004780 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853004781 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853004782 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853004783 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853004784 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853004785 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853004786 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853004787 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853004788 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853004789 Domain of unknown function (DUF4282); Region: DUF4282; pfam14110 471853004790 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 471853004791 Eukaryotic phosphomannomutase; Region: PMM; cl17107 471853004792 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 471853004793 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 471853004794 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471853004795 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 471853004796 Moco binding site; other site 471853004797 metal coordination site [ion binding]; other site 471853004798 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853004799 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853004800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853004801 Walker A/P-loop; other site 471853004802 ATP binding site [chemical binding]; other site 471853004803 Q-loop/lid; other site 471853004804 ABC transporter signature motif; other site 471853004805 Walker B; other site 471853004806 D-loop; other site 471853004807 H-loop/switch region; other site 471853004808 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853004809 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853004810 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 471853004811 Walker A/P-loop; other site 471853004812 ATP binding site [chemical binding]; other site 471853004813 Q-loop/lid; other site 471853004814 ABC transporter signature motif; other site 471853004815 Walker B; other site 471853004816 D-loop; other site 471853004817 H-loop/switch region; other site 471853004818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471853004819 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 471853004820 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 471853004821 ABC1 family; Region: ABC1; cl17513 471853004822 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471853004823 active site 471853004824 ATP binding site [chemical binding]; other site 471853004825 GAF domain; Region: GAF; pfam01590 471853004826 ANTAR (AmiR and NasR transcription antitermination regulators) is an RNA-binding domain found in bacterial transcription antitermination regulatory proteins; Region: ANTAR; smart01012 471853004827 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471853004828 nucleoside/Zn binding site; other site 471853004829 catalytic motif [active] 471853004830 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853004831 FAD binding domain; Region: FAD_binding_4; pfam01565 471853004832 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853004833 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471853004834 nucleotide binding site [chemical binding]; other site 471853004835 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 471853004836 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 471853004837 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 471853004838 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 471853004839 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 471853004840 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 471853004841 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 471853004842 FAD binding domain in molybdopterin dehydrogenase; Region: FAD_binding_5; pfam00941 471853004843 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; cl08390 471853004844 methylenetetrahydromethanopterin reductase; Provisional; Region: PRK02271 471853004845 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853004846 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 471853004847 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853004848 active site 471853004849 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853004850 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853004851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004852 dimer interface [polypeptide binding]; other site 471853004853 conserved gate region; other site 471853004854 putative PBP binding loops; other site 471853004855 ABC-ATPase subunit interface; other site 471853004856 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004858 dimer interface [polypeptide binding]; other site 471853004859 conserved gate region; other site 471853004860 putative PBP binding loops; other site 471853004861 ABC-ATPase subunit interface; other site 471853004862 cytosine deaminase; Provisional; Region: PRK05985 471853004863 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 471853004864 active site 471853004865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853004866 putative substrate translocation pore; other site 471853004867 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853004868 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471853004869 metal binding site [ion binding]; metal-binding site 471853004870 substrate binding pocket [chemical binding]; other site 471853004871 Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_11; cd12175 471853004872 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 471853004873 putative ligand binding site [chemical binding]; other site 471853004874 putative NAD binding site [chemical binding]; other site 471853004875 catalytic site [active] 471853004876 glucose-6-phosphate dehydrogenase (coenzyme-F420); Region: F420_G6P_DH; TIGR03554 471853004877 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853004878 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853004879 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 471853004880 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 471853004881 XdhC Rossmann domain; Region: XdhC_C; pfam13478 471853004882 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 471853004883 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853004884 FeS/SAM binding site; other site 471853004885 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 471853004886 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 471853004887 MoaE interaction surface [polypeptide binding]; other site 471853004888 MoeB interaction surface [polypeptide binding]; other site 471853004889 thiocarboxylated glycine; other site 471853004890 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853004891 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 471853004892 MoaE homodimer interface [polypeptide binding]; other site 471853004893 MoaD interaction [polypeptide binding]; other site 471853004894 active site residues [active] 471853004895 MoaC family. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine derivative to the precursor...; Region: MoaC; cl00242 471853004896 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 471853004897 trimer interface [polypeptide binding]; other site 471853004898 dimer interface [polypeptide binding]; other site 471853004899 putative active site [active] 471853004900 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 471853004901 MPT binding site; other site 471853004902 trimer interface [polypeptide binding]; other site 471853004903 molybdopterin biosynthesis-like protein MoeZ; Validated; Region: PRK07878 471853004904 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 471853004905 ATP binding site [chemical binding]; other site 471853004906 substrate interface [chemical binding]; other site 471853004907 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471853004908 active site residue [active] 471853004909 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853004910 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853004911 DNA binding site [nucleotide binding] 471853004912 domain linker motif; other site 471853004913 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853004914 ligand binding site [chemical binding]; other site 471853004915 dimerization interface [polypeptide binding]; other site 471853004916 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 471853004917 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853004919 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004920 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004921 dimer interface [polypeptide binding]; other site 471853004922 conserved gate region; other site 471853004923 putative PBP binding loops; other site 471853004924 ABC-ATPase subunit interface; other site 471853004925 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004927 dimer interface [polypeptide binding]; other site 471853004928 conserved gate region; other site 471853004929 putative PBP binding loops; other site 471853004930 ABC-ATPase subunit interface; other site 471853004931 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853004932 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853004933 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853004934 DNA binding residues [nucleotide binding] 471853004935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 471853004936 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 471853004937 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 471853004938 putative active site [active] 471853004939 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853004940 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 471853004941 substrate binding site [chemical binding]; other site 471853004942 dimer interface [polypeptide binding]; other site 471853004943 ATP binding site [chemical binding]; other site 471853004944 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 471853004945 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853004946 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853004947 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853004948 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853004949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004950 dimer interface [polypeptide binding]; other site 471853004951 conserved gate region; other site 471853004952 putative PBP binding loops; other site 471853004953 ABC-ATPase subunit interface; other site 471853004954 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853004955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853004956 dimer interface [polypeptide binding]; other site 471853004957 conserved gate region; other site 471853004958 putative PBP binding loops; other site 471853004959 ABC-ATPase subunit interface; other site 471853004960 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853004961 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853004962 beta-Glucocerebrosidase 2 N terminal; Region: GBA2_N; pfam12215 471853004963 Predicted bile acid beta-glucosidase [Carbohydrate transport and metabolism]; Region: COG4354 471853004964 Protein of unknown function, DUF608; Region: DUF608; pfam04685 471853004965 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 471853004966 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853004967 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853004968 active site 471853004969 metal binding site [ion binding]; metal-binding site 471853004970 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_6; cd07824 471853004971 putative hydrophobic ligand binding site [chemical binding]; other site 471853004972 HicB family; Region: HicB; pfam05534 471853004973 Uncharacterized conserved protein [Function unknown]; Region: COG3595 471853004974 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 471853004975 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 471853004976 putative active site [active] 471853004977 redox center [active] 471853004978 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cl00364 471853004979 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471853004980 Domain of unknown function DUF21; Region: DUF21; pfam01595 471853004981 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471853004982 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471853004983 Domain of unknown function DUF21; Region: DUF21; pfam01595 471853004984 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471853004985 Transporter associated domain; Region: CorC_HlyC; pfam03471 471853004986 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 471853004987 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 471853004988 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853004989 MarR family; Region: MarR; pfam01047 471853004990 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 471853004991 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471853004992 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 471853004993 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853004994 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853004995 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 471853004996 Ferritin-like domain; Region: Ferritin; pfam00210 471853004997 dimerization interface [polypeptide binding]; other site 471853004998 DPS ferroxidase diiron center [ion binding]; other site 471853004999 ion pore; other site 471853005000 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471853005001 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853005002 active site 471853005003 HIGH motif; other site 471853005004 nucleotide binding site [chemical binding]; other site 471853005005 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853005006 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471853005007 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853005008 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853005009 active site 471853005010 KMSKS motif; other site 471853005011 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 471853005012 tRNA binding surface [nucleotide binding]; other site 471853005013 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471853005014 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853005015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853005016 active site 471853005017 phosphorylation site [posttranslational modification] 471853005018 intermolecular recognition site; other site 471853005019 dimerization interface [polypeptide binding]; other site 471853005020 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853005021 DNA binding residues [nucleotide binding] 471853005022 dimerization interface [polypeptide binding]; other site 471853005023 Histidine kinase; Region: HisKA_3; pfam07730 471853005024 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853005025 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471853005026 RibD C-terminal domain; Region: RibD_C; cl17279 471853005027 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471853005028 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 471853005029 AAA-like domain; Region: AAA_10; pfam12846 471853005030 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471853005031 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 471853005032 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 471853005033 Competence protein; Region: Competence; pfam03772 471853005034 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 471853005035 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471853005036 hypothetical protein; Reviewed; Region: PRK07914 471853005037 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 471853005038 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 471853005039 PemK-like protein; Region: PemK; pfam02452 471853005040 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853005041 GTP-binding protein LepA; Provisional; Region: PRK05433 471853005042 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 471853005043 G1 box; other site 471853005044 putative GEF interaction site [polypeptide binding]; other site 471853005045 GTP/Mg2+ binding site [chemical binding]; other site 471853005046 Switch I region; other site 471853005047 G2 box; other site 471853005048 G3 box; other site 471853005049 Switch II region; other site 471853005050 G4 box; other site 471853005051 G5 box; other site 471853005052 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 471853005053 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 471853005054 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 471853005055 Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729 471853005056 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853005057 FeS/SAM binding site; other site 471853005058 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 471853005059 Protein of unknown function (DUF3097); Region: DUF3097; pfam11296 471853005060 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 471853005061 HTH domain; Region: HTH_11; cl17392 471853005062 chaperone protein DnaJ; Provisional; Region: PRK14278 471853005063 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471853005064 HSP70 interaction site [polypeptide binding]; other site 471853005065 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 471853005066 Zn binding sites [ion binding]; other site 471853005067 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471853005068 dimer interface [polypeptide binding]; other site 471853005069 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 471853005070 PhoH-like protein; Region: PhoH; pfam02562 471853005071 metal-binding heat shock protein; Provisional; Region: PRK00016 471853005072 GTPase Era; Reviewed; Region: era; PRK00089 471853005073 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 471853005074 G1 box; other site 471853005075 GTP/Mg2+ binding site [chemical binding]; other site 471853005076 Switch I region; other site 471853005077 G2 box; other site 471853005078 Switch II region; other site 471853005079 G3 box; other site 471853005080 G4 box; other site 471853005081 G5 box; other site 471853005082 KH domain; Region: KH_2; pfam07650 471853005083 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853005084 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471853005085 active site 471853005086 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471853005087 phosphopeptide binding site; other site 471853005088 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471853005089 Protein kinase domain; Region: Pkinase; pfam00069 471853005090 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471853005091 active site 471853005092 ATP binding site [chemical binding]; other site 471853005093 substrate binding site [chemical binding]; other site 471853005094 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853005095 substrate binding site [chemical binding]; other site 471853005096 activation loop (A-loop); other site 471853005097 activation loop (A-loop); other site 471853005098 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471853005099 Interdomain contacts; other site 471853005100 Cytokine receptor motif; other site 471853005101 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471853005102 Interdomain contacts; other site 471853005103 Cytokine receptor motif; other site 471853005104 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471853005105 Interdomain contacts; other site 471853005106 Cytokine receptor motif; other site 471853005107 MoxR-like ATPases [General function prediction only]; Region: COG0714 471853005108 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853005109 Walker A motif; other site 471853005110 ATP binding site [chemical binding]; other site 471853005111 Walker B motif; other site 471853005112 arginine finger; other site 471853005113 Protein of unknown function DUF58; Region: DUF58; pfam01882 471853005114 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471853005115 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471853005116 FHA domain; Region: FHA; pfam00498 471853005117 2-isopropylmalate synthase; Validated; Region: PRK03739 471853005118 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 471853005119 active site 471853005120 catalytic residues [active] 471853005121 metal binding site [ion binding]; metal-binding site 471853005122 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 471853005123 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 471853005124 Lumazine binding domain; Region: Lum_binding; pfam00677 471853005125 Lumazine binding domain; Region: Lum_binding; pfam00677 471853005126 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 471853005127 Recombination protein O N terminal; Region: RecO_N; pfam11967 471853005128 Recombination protein O C terminal; Region: RecO_C; pfam02565 471853005129 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 471853005130 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 471853005131 catalytic residue [active] 471853005132 putative FPP diphosphate binding site; other site 471853005133 putative FPP binding hydrophobic cleft; other site 471853005134 dimer interface [polypeptide binding]; other site 471853005135 putative IPP diphosphate binding site; other site 471853005136 RibD C-terminal domain; Region: RibD_C; cl17279 471853005137 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 471853005138 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471853005139 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471853005140 metal binding site 2 [ion binding]; metal-binding site 471853005141 putative DNA binding helix; other site 471853005142 metal binding site 1 [ion binding]; metal-binding site 471853005143 dimer interface [polypeptide binding]; other site 471853005144 structural Zn2+ binding site [ion binding]; other site 471853005145 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 471853005146 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 471853005147 ABC-ATPase subunit interface; other site 471853005148 dimer interface [polypeptide binding]; other site 471853005149 putative PBP binding regions; other site 471853005150 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471853005151 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 471853005152 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471853005153 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 471853005154 intersubunit interface [polypeptide binding]; other site 471853005155 glycyl-tRNA synthetase; Provisional; Region: PRK04173 471853005156 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471853005157 motif 1; other site 471853005158 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 471853005159 active site 471853005160 motif 2; other site 471853005161 motif 3; other site 471853005162 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 471853005163 anticodon binding site; other site 471853005164 YibE/F-like protein; Region: YibE_F; pfam07907 471853005165 Thioesterase-like superfamily; Region: 4HBT_3; pfam13622 471853005166 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 471853005167 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 471853005168 FMN binding site [chemical binding]; other site 471853005169 active site 471853005170 catalytic residues [active] 471853005171 substrate binding site [chemical binding]; other site 471853005172 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853005173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853005174 DNA binding site [nucleotide binding] 471853005175 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_10; cd06292 471853005176 putative dimerization interface [polypeptide binding]; other site 471853005177 putative ligand binding site [chemical binding]; other site 471853005178 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853005179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005180 dimer interface [polypeptide binding]; other site 471853005181 conserved gate region; other site 471853005182 putative PBP binding loops; other site 471853005183 ABC-ATPase subunit interface; other site 471853005184 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853005185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005186 dimer interface [polypeptide binding]; other site 471853005187 conserved gate region; other site 471853005188 putative PBP binding loops; other site 471853005189 ABC-ATPase subunit interface; other site 471853005190 Uncharacterized conserved protein (DUF2277); Region: DUF2277; pfam10041 471853005191 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 471853005192 active site 471853005193 catalytic site [active] 471853005194 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 471853005195 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471853005196 Zn2+ binding site [ion binding]; other site 471853005197 Mg2+ binding site [ion binding]; other site 471853005198 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 471853005199 probable F420-dependent oxidoreductase, MSMEG_2906 family; Region: F420_MSMEG_2906; TIGR03856 471853005200 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853005201 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853005202 DNA primase, catalytic core; Region: dnaG; TIGR01391 471853005203 CHC2 zinc finger; Region: zf-CHC2; pfam01807 471853005204 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 471853005205 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 471853005206 active site 471853005207 metal binding site [ion binding]; metal-binding site 471853005208 interdomain interaction site; other site 471853005209 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 471853005210 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853005211 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853005212 FMN-dependent oxidoreductase, nitrilotriacetate monooxygenase family; Region: FMN_nitrolo; TIGR03860 471853005213 nitrilotriacetate monoxygenase oxidizes nitrilotriacetate utilizing reduced flavin mononucleotide (FMNH2) and oxygen. The FMNH2 is provided by an NADH:flavin mononucleotide (FMN) oxidorductase that uses NADH to reduce FMN to FMNH2; Region: Nitrilotriacetate_monoxgenase; cd01095 471853005214 active site 471853005215 non-prolyl cis peptide bond; other site 471853005216 sulfur acquisition oxidoreductase, SfnB family; Region: sulfur_SfnB; TIGR04022 471853005217 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471853005218 active site 471853005219 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853005220 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853005221 Walker A/P-loop; other site 471853005222 ATP binding site [chemical binding]; other site 471853005223 Q-loop/lid; other site 471853005224 ABC transporter signature motif; other site 471853005225 Walker B; other site 471853005226 D-loop; other site 471853005227 H-loop/switch region; other site 471853005228 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853005229 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853005230 Walker A/P-loop; other site 471853005231 ATP binding site [chemical binding]; other site 471853005232 Q-loop/lid; other site 471853005233 ABC transporter signature motif; other site 471853005234 Walker B; other site 471853005235 D-loop; other site 471853005236 H-loop/switch region; other site 471853005237 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853005238 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471853005239 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005240 dimer interface [polypeptide binding]; other site 471853005241 conserved gate region; other site 471853005242 putative PBP binding loops; other site 471853005243 ABC-ATPase subunit interface; other site 471853005244 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853005245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005246 dimer interface [polypeptide binding]; other site 471853005247 conserved gate region; other site 471853005248 putative PBP binding loops; other site 471853005249 ABC-ATPase subunit interface; other site 471853005250 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853005251 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_15; cd08492 471853005252 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471853005253 active site 471853005254 catalytic residues [active] 471853005255 metal binding site [ion binding]; metal-binding site 471853005256 Protein of unknown function (DUF3145); Region: DUF3145; pfam11343 471853005257 Phosphotransferase enzyme family; Region: APH; pfam01636 471853005258 Protein of unknown function (DUF1679); Region: DUF1679; pfam07914 471853005259 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853005260 active site 471853005261 metal binding site [ion binding]; metal-binding site 471853005262 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 471853005263 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853005264 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471853005265 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 471853005266 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 471853005267 dimer interface [polypeptide binding]; other site 471853005268 active site 471853005269 acyl carrier protein; Provisional; Region: acpP; PRK00982 471853005270 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 471853005271 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 471853005272 dimer interface [polypeptide binding]; other site 471853005273 active site 471853005274 CoA binding pocket [chemical binding]; other site 471853005275 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 471853005276 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 471853005277 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 471853005278 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 471853005279 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 471853005280 dimer interface [polypeptide binding]; other site 471853005281 TPP-binding site [chemical binding]; other site 471853005282 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 471853005283 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471853005284 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853005285 CAAX protease self-immunity; Region: Abi; pfam02517 471853005286 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 471853005287 Cupin; Region: Cupin_6; pfam12852 471853005288 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853005289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853005290 RibD C-terminal domain; Region: RibD_C; cl17279 471853005291 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853005292 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853005293 active site 471853005294 phosphorylation site [posttranslational modification] 471853005295 intermolecular recognition site; other site 471853005296 dimerization interface [polypeptide binding]; other site 471853005297 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853005298 DNA binding residues [nucleotide binding] 471853005299 dimerization interface [polypeptide binding]; other site 471853005300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471853005301 Histidine kinase; Region: HisKA_3; pfam07730 471853005302 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853005303 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853005304 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 471853005305 putative NAD(P) binding site [chemical binding]; other site 471853005306 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853005307 Putative glycolipid-binding; Region: Glycolipid_bind; pfam06475 471853005308 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853005309 active site 471853005310 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471853005311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853005312 S-adenosylmethionine binding site [chemical binding]; other site 471853005313 Acyltransferase family; Region: Acyl_transf_3; pfam01757 471853005314 Uncharacterized conserved protein [Function unknown]; Region: COG0327 471853005315 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471853005316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 471853005317 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 471853005318 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 471853005319 Putative zinc ribbon domain; Region: DUF164; pfam02591 471853005320 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853005321 active site 471853005322 metallochaperone-like domain; Region: TRASH; smart00746 471853005323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853005324 sequence-specific DNA binding site [nucleotide binding]; other site 471853005325 salt bridge; other site 471853005326 hypothetical protein; Validated; Region: PRK02101 471853005327 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 471853005328 active site 471853005329 metal binding site [ion binding]; metal-binding site 471853005330 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853005331 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471853005332 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853005333 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 471853005334 active sites [active] 471853005335 tetramer interface [polypeptide binding]; other site 471853005336 urocanate hydratase; Provisional; Region: PRK05414 471853005337 imidazolonepropionase; Provisional; Region: PRK14085 471853005338 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853005339 active site 471853005340 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 471853005341 MarR family; Region: MarR; pfam01047 471853005342 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 471853005343 A new structural DNA glycosylase; Region: AlkD_like; cd06561 471853005344 active site 471853005345 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 471853005346 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853005347 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471853005348 nucleotide binding site [chemical binding]; other site 471853005349 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 471853005350 oligomerization interface [polypeptide binding]; other site 471853005351 active site 471853005352 metal binding site [ion binding]; metal-binding site 471853005353 NAD synthetase; Provisional; Region: PRK13981 471853005354 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 471853005355 multimer interface [polypeptide binding]; other site 471853005356 active site 471853005357 catalytic triad [active] 471853005358 protein interface 1 [polypeptide binding]; other site 471853005359 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 471853005360 homodimer interface [polypeptide binding]; other site 471853005361 NAD binding pocket [chemical binding]; other site 471853005362 ATP binding pocket [chemical binding]; other site 471853005363 Mg binding site [ion binding]; other site 471853005364 active-site loop [active] 471853005365 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 471853005366 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471853005367 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471853005368 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 471853005369 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471853005370 metal binding triad; other site 471853005371 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471853005372 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471853005373 metal binding triad; other site 471853005374 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471853005375 AAA ATPase domain; Region: AAA_16; pfam13191 471853005376 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853005377 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853005378 DNA binding residues [nucleotide binding] 471853005379 dimerization interface [polypeptide binding]; other site 471853005380 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471853005381 glutamine synthetase, type I; Region: GlnA; TIGR00653 471853005382 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 471853005383 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 471853005384 RDD family; Region: RDD; pfam06271 471853005385 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 471853005386 lipoyl synthase; Provisional; Region: PRK05481 471853005387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853005388 FeS/SAM binding site; other site 471853005389 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 471853005390 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471853005391 active site 471853005392 ATP binding site [chemical binding]; other site 471853005393 substrate binding site [chemical binding]; other site 471853005394 activation loop (A-loop); other site 471853005395 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853005396 active site 471853005397 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471853005398 E3 interaction surface; other site 471853005399 lipoyl attachment site [posttranslational modification]; other site 471853005400 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471853005401 E3 interaction surface; other site 471853005402 lipoyl attachment site [posttranslational modification]; other site 471853005403 e3 binding domain; Region: E3_binding; pfam02817 471853005404 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 471853005405 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471853005406 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 471853005407 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853005408 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853005409 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471853005410 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471853005411 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853005412 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471853005413 Transcriptional regulator; Region: Rrf2; cl17282 471853005414 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 471853005415 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 471853005416 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853005417 Protein of unknown function, DUF624; Region: DUF624; pfam04854 471853005418 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853005419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005420 dimer interface [polypeptide binding]; other site 471853005421 conserved gate region; other site 471853005422 ABC-ATPase subunit interface; other site 471853005423 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853005424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005425 dimer interface [polypeptide binding]; other site 471853005426 conserved gate region; other site 471853005427 putative PBP binding loops; other site 471853005428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853005429 ABC-ATPase subunit interface; other site 471853005430 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471853005431 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471853005432 interface (dimer of trimers) [polypeptide binding]; other site 471853005433 Substrate-binding/catalytic site; other site 471853005434 Zn-binding sites [ion binding]; other site 471853005435 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 471853005436 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 471853005437 quinone interaction residues [chemical binding]; other site 471853005438 active site 471853005439 catalytic residues [active] 471853005440 FMN binding site [chemical binding]; other site 471853005441 substrate binding site [chemical binding]; other site 471853005442 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853005443 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853005444 active site 471853005445 catalytic tetrad [active] 471853005446 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 471853005447 hypothetical protein; Provisional; Region: PRK07907 471853005448 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 471853005449 active site 471853005450 metal binding site [ion binding]; metal-binding site 471853005451 dimer interface [polypeptide binding]; other site 471853005452 Glycerate kinase family; Region: Gly_kinase; cl00841 471853005453 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 471853005454 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471853005455 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 471853005456 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 471853005457 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 471853005458 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 471853005459 D-pathway; other site 471853005460 Putative ubiquinol binding site [chemical binding]; other site 471853005461 Low-spin heme (heme b) binding site [chemical binding]; other site 471853005462 Putative water exit pathway; other site 471853005463 Binuclear center (heme o3/CuB) [ion binding]; other site 471853005464 K-pathway; other site 471853005465 Putative proton exit pathway; other site 471853005466 Cytochrome c oxidase subunit IV; Region: Cyt_c_ox_IV; pfam12270 471853005467 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 471853005468 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 471853005469 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 471853005470 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 471853005471 heme bH binding site [chemical binding]; other site 471853005472 intrachain domain interface; other site 471853005473 heme bL binding site [chemical binding]; other site 471853005474 interchain domain interface [polypeptide binding]; other site 471853005475 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N_2; pfam13631 471853005476 Qo binding site; other site 471853005477 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 471853005478 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 471853005479 iron-sulfur cluster [ion binding]; other site 471853005480 [2Fe-2S] cluster binding site [ion binding]; other site 471853005481 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 471853005482 Cytochrome c; Region: Cytochrom_C; pfam00034 471853005483 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 471853005484 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 471853005485 Subunit I/III interface [polypeptide binding]; other site 471853005486 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853005487 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 471853005488 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471853005489 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471853005490 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471853005491 AsnC family; Region: AsnC_trans_reg; pfam01037 471853005492 succinic semialdehyde dehydrogenase; Reviewed; Region: gabD2; PRK09407 471853005493 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853005494 NAD(P) binding site [chemical binding]; other site 471853005495 catalytic residues [active] 471853005496 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853005497 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471853005498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853005499 catalytic residue [active] 471853005500 FAD-linked oxidoreductase; Region: bact_FAD_ox; TIGR01679 471853005501 FAD binding domain; Region: FAD_binding_4; pfam01565 471853005502 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 471853005503 hypothetical protein; Validated; Region: PRK07883 471853005504 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471853005505 active site 471853005506 catalytic site [active] 471853005507 substrate binding site [chemical binding]; other site 471853005508 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471853005509 GIY-YIG motif/motif A; other site 471853005510 active site 471853005511 catalytic site [active] 471853005512 putative DNA binding site [nucleotide binding]; other site 471853005513 metal binding site [ion binding]; metal-binding site 471853005514 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471853005515 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 471853005516 acyl-activating enzyme (AAE) consensus motif; other site 471853005517 putative AMP binding site [chemical binding]; other site 471853005518 putative active site [active] 471853005519 putative CoA binding site [chemical binding]; other site 471853005520 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 471853005521 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471853005522 nucleotide binding site [chemical binding]; other site 471853005523 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471853005524 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471853005525 putative acyl-acceptor binding pocket; other site 471853005526 pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated; Region: PRK06555 471853005527 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 471853005528 active site 471853005529 ADP/pyrophosphate binding site [chemical binding]; other site 471853005530 allosteric effector site; other site 471853005531 fructose-1,6-bisphosphate binding site; other site 471853005532 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 471853005533 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 471853005534 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 471853005535 Moco binding site; other site 471853005536 metal coordination site [ion binding]; other site 471853005537 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 471853005538 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 471853005539 active site 471853005540 ATP binding site [chemical binding]; other site 471853005541 substrate binding site [chemical binding]; other site 471853005542 activation loop (A-loop); other site 471853005543 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853005544 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853005545 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 471853005546 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853005547 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 471853005548 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471853005549 substrate binding pocket [chemical binding]; other site 471853005550 substrate-Mg2+ binding site; other site 471853005551 aspartate-rich region 1; other site 471853005552 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471853005553 aspartate-rich region 2; other site 471853005554 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 471853005555 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 471853005556 Ligand Binding Site [chemical binding]; other site 471853005557 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 471853005558 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 471853005559 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471853005560 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 471853005561 lipoyl attachment site [posttranslational modification]; other site 471853005562 glycine dehydrogenase; Provisional; Region: PRK05367 471853005563 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471853005564 tetramer interface [polypeptide binding]; other site 471853005565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853005566 catalytic residue [active] 471853005567 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 471853005568 tetramer interface [polypeptide binding]; other site 471853005569 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853005570 catalytic residue [active] 471853005571 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 471853005572 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 471853005573 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853005574 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 471853005575 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853005576 DNA binding residues [nucleotide binding] 471853005577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853005578 dimerization interface [polypeptide binding]; other site 471853005579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853005580 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853005581 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 471853005582 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853005583 Mg2+ binding site [ion binding]; other site 471853005584 G-X-G motif; other site 471853005585 DNA gyrase B; Region: DNA_gyraseB; pfam00204 471853005586 ATP binding site [chemical binding]; other site 471853005587 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 471853005588 active site 471853005589 metal binding site [ion binding]; metal-binding site 471853005590 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 471853005591 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471853005592 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853005593 hypothetical protein; Provisional; Region: PRK07907 471853005594 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 471853005595 active site 471853005596 metal binding site [ion binding]; metal-binding site 471853005597 dimer interface [polypeptide binding]; other site 471853005598 Predicted membrane protein [Function unknown]; Region: COG1288 471853005599 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 471853005600 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 471853005601 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 471853005602 CAP-like domain; other site 471853005603 active site 471853005604 primary dimer interface [polypeptide binding]; other site 471853005605 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853005606 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 471853005607 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 471853005608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853005609 Coenzyme A binding pocket [chemical binding]; other site 471853005610 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 471853005611 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 471853005612 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 471853005613 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471853005614 thymidine kinase; Provisional; Region: PRK04296 471853005615 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 471853005616 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 471853005617 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471853005618 active site 471853005619 dimerization interface [polypeptide binding]; other site 471853005620 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 471853005621 Protein of unknown function (DUF3093); Region: DUF3093; pfam11292 471853005622 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471853005623 trimer interface [polypeptide binding]; other site 471853005624 active site 471853005625 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 471853005626 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 471853005627 ssDNA binding site; other site 471853005628 generic binding surface II; other site 471853005629 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471853005630 TrkA-N domain; Region: TrkA_N; pfam02254 471853005631 TrkA-C domain; Region: TrkA_C; pfam02080 471853005632 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471853005633 TrkA-N domain; Region: TrkA_N; pfam02254 471853005634 TrkA-C domain; Region: TrkA_C; pfam02080 471853005635 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 471853005636 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 471853005637 TRAM domain; Region: TRAM; cl01282 471853005638 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 471853005639 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853005640 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853005641 motif II; other site 471853005642 aconitate hydratase; Validated; Region: PRK09277 471853005643 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 471853005644 substrate binding site [chemical binding]; other site 471853005645 ligand binding site [chemical binding]; other site 471853005646 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 471853005647 substrate binding site [chemical binding]; other site 471853005648 Serpin (serine protease inhibitor); Region: Serpin; pfam00079 471853005649 reactive center loop; other site 471853005650 Phosphotransferase enzyme family; Region: APH; pfam01636 471853005651 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853005652 active site 471853005653 substrate binding site [chemical binding]; other site 471853005654 ATP binding site [chemical binding]; other site 471853005655 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 471853005656 putative active site [active] 471853005657 putative CoA binding site [chemical binding]; other site 471853005658 nudix motif; other site 471853005659 metal binding site [ion binding]; metal-binding site 471853005660 Predicted membrane protein [Function unknown]; Region: COG2860 471853005661 UPF0126 domain; Region: UPF0126; pfam03458 471853005662 UPF0126 domain; Region: UPF0126; pfam03458 471853005663 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK07807 471853005664 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471853005665 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 471853005666 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471853005667 active site 471853005668 YCII-related domain; Region: YCII; cl00999 471853005669 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853005670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005671 dimer interface [polypeptide binding]; other site 471853005672 conserved gate region; other site 471853005673 ABC-ATPase subunit interface; other site 471853005674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853005675 dimer interface [polypeptide binding]; other site 471853005676 conserved gate region; other site 471853005677 putative PBP binding loops; other site 471853005678 ABC-ATPase subunit interface; other site 471853005679 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853005680 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853005681 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853005682 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853005683 DNA binding site [nucleotide binding] 471853005684 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853005685 Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408 471853005686 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 471853005687 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 471853005688 TPP-binding site; other site 471853005689 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471853005690 PYR/PP interface [polypeptide binding]; other site 471853005691 dimer interface [polypeptide binding]; other site 471853005692 TPP binding site [chemical binding]; other site 471853005693 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471853005694 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471853005695 substrate binding site [chemical binding]; other site 471853005696 oxyanion hole (OAH) forming residues; other site 471853005697 trimer interface [polypeptide binding]; other site 471853005698 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 471853005699 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 471853005700 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 471853005701 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471853005702 acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930 471853005703 dimer interface [polypeptide binding]; other site 471853005704 active site 471853005705 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 471853005706 putative active site [active] 471853005707 putative substrate binding site [chemical binding]; other site 471853005708 catalytic site [active] 471853005709 HRDC domain; Region: HRDC; pfam00570 471853005710 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471853005711 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 471853005712 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; cl00895 471853005713 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 471853005714 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471853005715 AFG1-like ATPase; Region: AFG1_ATPase; pfam03969 471853005716 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 471853005717 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 471853005718 nucleotide binding site/active site [active] 471853005719 HIT family signature motif; other site 471853005720 catalytic residue [active] 471853005721 malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402 471853005722 N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853 471853005723 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 471853005724 catalytic site [active] 471853005725 active site 471853005726 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 471853005727 maltooligosyl trehalose synthase; Provisional; Region: PRK14511 471853005728 Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336 471853005729 active site 471853005730 catalytic site [active] 471853005731 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 471853005732 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 471853005733 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 471853005734 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 471853005735 active site 471853005736 catalytic site [active] 471853005737 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 471853005738 Predicted membrane protein (DUF2319); Region: DUF2319; pfam10081 471853005739 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853005740 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 471853005741 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 471853005742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853005743 catalytic residue [active] 471853005744 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853005745 inhibitor site; inhibition site 471853005746 active site 471853005747 dimer interface [polypeptide binding]; other site 471853005748 catalytic residue [active] 471853005749 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 471853005750 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 471853005751 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 471853005752 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 471853005753 active site 471853005754 dimer interface [polypeptide binding]; other site 471853005755 motif 1; other site 471853005756 motif 2; other site 471853005757 motif 3; other site 471853005758 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 471853005759 anticodon binding site; other site 471853005760 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 471853005761 nucleotide binding site/active site [active] 471853005762 HIT family signature motif; other site 471853005763 catalytic residue [active] 471853005764 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 471853005765 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 471853005766 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 471853005767 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 471853005768 putative acyl-acceptor binding pocket; other site 471853005769 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853005770 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471853005771 Protease prsW family; Region: PrsW-protease; pfam13367 471853005772 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 471853005773 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 471853005774 active site 471853005775 multimer interface [polypeptide binding]; other site 471853005776 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily requires a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_26; cd04685 471853005777 nudix motif; other site 471853005778 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 471853005779 predicted active site [active] 471853005780 catalytic triad [active] 471853005781 hypothetical protein; Validated; Region: PRK00110 471853005782 Protein of unknown function (DUF2630); Region: DUF2630; pfam10944 471853005783 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471853005784 hydrophobic ligand binding site; other site 471853005785 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 471853005786 active site 471853005787 putative DNA-binding cleft [nucleotide binding]; other site 471853005788 dimer interface [polypeptide binding]; other site 471853005789 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 471853005790 RuvA N terminal domain; Region: RuvA_N; pfam01330 471853005791 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 471853005792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853005793 Walker A motif; other site 471853005794 ATP binding site [chemical binding]; other site 471853005795 Walker B motif; other site 471853005796 arginine finger; other site 471853005797 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 471853005798 Preprotein translocase subunit; Region: YajC; pfam02699 471853005799 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 471853005800 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 471853005801 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 471853005802 Protein export membrane protein; Region: SecD_SecF; pfam02355 471853005803 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853005804 active site 471853005805 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 471853005806 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471853005807 Zn2+ binding site [ion binding]; other site 471853005808 Mg2+ binding site [ion binding]; other site 471853005809 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471853005810 synthetase active site [active] 471853005811 NTP binding site [chemical binding]; other site 471853005812 metal binding site [ion binding]; metal-binding site 471853005813 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 471853005814 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 471853005815 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471853005816 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 471853005817 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 471853005818 active site 471853005819 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 471853005820 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 471853005821 dimer interface [polypeptide binding]; other site 471853005822 motif 1; other site 471853005823 active site 471853005824 motif 2; other site 471853005825 motif 3; other site 471853005826 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 471853005827 anticodon binding site; other site 471853005828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853005829 Radical SAM superfamily; Region: Radical_SAM; pfam04055 471853005830 FeS/SAM binding site; other site 471853005831 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 471853005832 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471853005833 ATP binding site [chemical binding]; other site 471853005834 Mg++ binding site [ion binding]; other site 471853005835 motif III; other site 471853005836 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853005837 nucleotide binding region [chemical binding]; other site 471853005838 ATP-binding site [chemical binding]; other site 471853005839 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 471853005840 putative RNA binding site [nucleotide binding]; other site 471853005841 aspartate aminotransferase; Provisional; Region: PRK05764 471853005842 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853005843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853005844 homodimer interface [polypeptide binding]; other site 471853005845 catalytic residue [active] 471853005846 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 471853005847 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 471853005848 dimer interface [polypeptide binding]; other site 471853005849 anticodon binding site; other site 471853005850 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 471853005851 homodimer interface [polypeptide binding]; other site 471853005852 motif 1; other site 471853005853 active site 471853005854 motif 2; other site 471853005855 GAD domain; Region: GAD; pfam02938 471853005856 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471853005857 active site 471853005858 motif 3; other site 471853005859 MMPL family; Region: MMPL; pfam03176 471853005860 recombination factor protein RarA; Reviewed; Region: PRK13342 471853005861 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853005862 Walker A motif; other site 471853005863 ATP binding site [chemical binding]; other site 471853005864 Walker B motif; other site 471853005865 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 471853005866 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 471853005867 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 471853005868 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471853005869 RNA binding surface [nucleotide binding]; other site 471853005870 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 471853005871 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 471853005872 tRNA synthetases class II (A); Region: tRNA-synt_2c; pfam01411 471853005873 motif 1; other site 471853005874 active site 471853005875 motif 2; other site 471853005876 motif 3; other site 471853005877 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 471853005878 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 471853005879 YceG-like family; Region: YceG; pfam02618 471853005880 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 471853005881 dimerization interface [polypeptide binding]; other site 471853005882 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 471853005883 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 471853005884 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 471853005885 shikimate binding site; other site 471853005886 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 471853005887 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 471853005888 Tetramer interface [polypeptide binding]; other site 471853005889 active site 471853005890 FMN-binding site [chemical binding]; other site 471853005891 shikimate kinase; Reviewed; Region: aroK; PRK00131 471853005892 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 471853005893 ADP binding site [chemical binding]; other site 471853005894 magnesium binding site [ion binding]; other site 471853005895 putative shikimate binding site; other site 471853005896 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 471853005897 dimer interface [polypeptide binding]; other site 471853005898 active site 471853005899 metal binding site [ion binding]; metal-binding site 471853005900 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853005901 dimerization interface [polypeptide binding]; other site 471853005902 putative DNA binding site [nucleotide binding]; other site 471853005903 putative Zn2+ binding site [ion binding]; other site 471853005904 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 471853005905 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 471853005906 tetramer interface [polypeptide binding]; other site 471853005907 active site 471853005908 Mg2+/Mn2+ binding site [ion binding]; other site 471853005909 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 471853005910 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 471853005911 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853005912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853005913 RibD C-terminal domain; Region: RibD_C; cl17279 471853005914 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853005915 elongation factor P; Validated; Region: PRK00529 471853005916 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 471853005917 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 471853005918 RNA binding site [nucleotide binding]; other site 471853005919 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 471853005920 RNA binding site [nucleotide binding]; other site 471853005921 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 471853005922 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase; Provisional; Region: PRK05205 471853005923 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 471853005924 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 471853005925 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471853005926 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471853005927 dihydroorotase; Validated; Region: pyrC; PRK09357 471853005928 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853005929 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 471853005930 active site 471853005931 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 471853005932 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 471853005933 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 471853005934 catalytic site [active] 471853005935 subunit interface [polypeptide binding]; other site 471853005936 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 471853005937 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471853005938 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471853005939 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 471853005940 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471853005941 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471853005942 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 471853005943 IMP binding site; other site 471853005944 dimer interface [polypeptide binding]; other site 471853005945 interdomain contacts; other site 471853005946 partial ornithine binding site; other site 471853005947 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 471853005948 active site 471853005949 dimer interface [polypeptide binding]; other site 471853005950 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 471853005951 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 471853005952 Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162 471853005953 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 471853005954 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 471853005955 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 471853005956 Guanylate kinase; Region: Guanylate_kin; pfam00625 471853005957 catalytic site [active] 471853005958 G-X2-G-X-G-K; other site 471853005959 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 471853005960 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 471853005961 Flavoprotein; Region: Flavoprotein; pfam02441 471853005962 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 471853005963 S-adenosylmethionine synthetase; Validated; Region: PRK05250 471853005964 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 471853005965 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 471853005966 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 471853005967 primosome assembly protein PriA; Provisional; Region: PRK14873 471853005968 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471853005969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853005970 motif II; other site 471853005971 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 471853005972 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 471853005973 putative active site [active] 471853005974 substrate binding site [chemical binding]; other site 471853005975 putative cosubstrate binding site; other site 471853005976 catalytic site [active] 471853005977 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 471853005978 substrate binding site [chemical binding]; other site 471853005979 16S rRNA methyltransferase B; Provisional; Region: PRK14902 471853005980 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223 471853005981 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 471853005982 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 471853005983 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 471853005984 substrate binding site [chemical binding]; other site 471853005985 hexamer interface [polypeptide binding]; other site 471853005986 metal binding site [ion binding]; metal-binding site 471853005987 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853005988 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471853005989 NMT1/THI5 like; Region: NMT1; pfam09084 471853005990 substrate binding pocket [chemical binding]; other site 471853005991 membrane-bound complex binding site; other site 471853005992 hinge residues; other site 471853005993 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 471853005994 homodimer interface [polypeptide binding]; other site 471853005995 putative metal binding site [ion binding]; other site 471853005996 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 471853005997 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 471853005998 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 471853005999 Protein of unknown function (DUF2581); Region: DUF2581; pfam10756 471853006000 Protein of unknown function (DUF3866); Region: DUF3866; pfam12982 471853006001 Protein of unknown function (DUF952); Region: DUF952; cl01393 471853006002 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853006003 WYL domain; Region: WYL; pfam13280 471853006004 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853006005 WYL domain; Region: WYL; pfam13280 471853006006 twin arginine-targeting protein translocase, TatA/E family; Region: tatAE; TIGR01411 471853006007 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 471853006008 diacylglycerol kinase; Reviewed; Region: PRK11914 471853006009 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471853006010 Superfamily II RNA helicase [DNA replication, recombination, and repair]; Region: COG4581 471853006011 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853006012 ATP binding site [chemical binding]; other site 471853006013 putative Mg++ binding site [ion binding]; other site 471853006014 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853006015 nucleotide binding region [chemical binding]; other site 471853006016 ATP-binding site [chemical binding]; other site 471853006017 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 471853006018 apolipoprotein N-acyltransferase; Region: lnt; TIGR00546 471853006019 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 471853006020 putative active site [active] 471853006021 catalytic triad [active] 471853006022 putative dimer interface [polypeptide binding]; other site 471853006023 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 471853006024 DXD motif; other site 471853006025 Putative Catalytic site; other site 471853006026 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 471853006027 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471853006028 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471853006029 nucleotide binding site/active site [active] 471853006030 HIT family signature motif; other site 471853006031 catalytic residue [active] 471853006032 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853006033 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853006034 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853006035 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853006036 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853006037 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853006038 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471853006039 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 471853006040 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 471853006041 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006042 Walker A/P-loop; other site 471853006043 ATP binding site [chemical binding]; other site 471853006044 Q-loop/lid; other site 471853006045 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471853006046 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006047 Walker A/P-loop; other site 471853006048 ATP binding site [chemical binding]; other site 471853006049 Q-loop/lid; other site 471853006050 ABC transporter signature motif; other site 471853006051 Walker B; other site 471853006052 D-loop; other site 471853006053 H-loop/switch region; other site 471853006054 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 471853006055 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471853006056 DinB superfamily; Region: DinB_2; pfam12867 471853006057 Protein of unknown function (DUF796); Region: DUF796; pfam05638 471853006058 Phosphotransferase enzyme family; Region: APH; pfam01636 471853006059 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853006060 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 471853006061 hydrophobic ligand binding site; other site 471853006062 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471853006063 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853006064 Predicted transcriptional regulators [Transcription]; Region: COG1733 471853006065 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471853006066 SCP-2 sterol transfer family; Region: SCP2; cl01225 471853006067 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853006068 DinB superfamily; Region: DinB_2; pfam12867 471853006069 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cl00942 471853006070 aromatic arch; other site 471853006071 DCoH dimer interaction site [polypeptide binding]; other site 471853006072 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 471853006073 DCoH tetramer interaction site [polypeptide binding]; other site 471853006074 substrate binding site [chemical binding]; other site 471853006075 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853006076 S-adenosylmethionine binding site [chemical binding]; other site 471853006077 RibD C-terminal domain; Region: RibD_C; cl17279 471853006078 YCII-related domain; Region: YCII; cl00999 471853006079 YCII-related domain; Region: YCII; cl00999 471853006080 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853006081 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853006082 TPR motif; other site 471853006083 binding surface 471853006084 AAA domain; Region: AAA_33; pfam13671 471853006085 Uncharacterized conserved protein [Function unknown]; Region: COG1262 471853006086 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 471853006087 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853006088 Sulfatase; Region: Sulfatase; pfam00884 471853006089 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 471853006090 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471853006091 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853006092 substrate binding site [chemical binding]; other site 471853006093 ATP binding site [chemical binding]; other site 471853006094 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 471853006095 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 471853006096 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 471853006097 DNA binding residues [nucleotide binding] 471853006098 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853006099 Bifunctional nuclease; Region: DNase-RNase; pfam02577 471853006100 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471853006101 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 471853006102 DNA binding residues [nucleotide binding] 471853006103 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 471853006104 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 471853006105 phosphopeptide binding site; other site 471853006106 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 471853006107 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471853006108 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 471853006109 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 471853006110 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853006111 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471853006112 Domain of unknown function (DUF4395); Region: DUF4395; pfam14340 471853006113 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471853006114 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853006115 active site 471853006116 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 471853006117 RNA/DNA hybrid binding site [nucleotide binding]; other site 471853006118 active site 471853006119 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 471853006120 DinB superfamily; Region: DinB_2; pfam12867 471853006121 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853006122 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 471853006123 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471853006124 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 471853006125 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 471853006126 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 471853006127 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 471853006128 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 471853006129 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853006130 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 471853006131 CAAX protease self-immunity; Region: Abi; pfam02517 471853006132 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853006133 PhoD-like phosphatase; Region: PhoD; pfam09423 471853006134 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853006135 putative active site [active] 471853006136 putative metal binding site [ion binding]; other site 471853006137 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853006138 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 471853006139 The Luminal domain, a dimerization domain, of Inositol-requiring protein 1-like proteins; Region: Luminal_IRE1_like; cl14874 471853006140 maltose O-acetyltransferase; Provisional; Region: PRK10092 471853006141 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 471853006142 active site 471853006143 substrate binding site [chemical binding]; other site 471853006144 trimer interface [polypeptide binding]; other site 471853006145 CoA binding site [chemical binding]; other site 471853006146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 471853006147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853006148 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853006149 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853006150 active site 471853006151 catalytic tetrad [active] 471853006152 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 471853006153 tellurite resistance protein TehB; Provisional; Region: PRK11207 471853006154 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853006155 S-adenosylmethionine binding site [chemical binding]; other site 471853006156 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471853006157 Carboxylesterase family; Region: COesterase; pfam00135 471853006158 substrate binding pocket [chemical binding]; other site 471853006159 catalytic triad [active] 471853006160 Domain of unknown function (DUF4342); Region: DUF4342; pfam14242 471853006161 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853006162 Coenzyme A binding pocket [chemical binding]; other site 471853006163 transcriptional activator FtrA; Provisional; Region: ftrA; PRK09393 471853006164 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 471853006165 conserved cys residue [active] 471853006166 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853006167 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853006168 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 471853006169 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 471853006170 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471853006171 MarR family; Region: MarR_2; pfam12802 471853006172 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853006173 hypothetical protein; Provisional; Region: PRK09256 471853006174 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471853006175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853006176 SIR2-like domain; Region: SIR2_2; pfam13289 471853006177 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 471853006178 cofactor binding site; other site 471853006179 DNA binding site [nucleotide binding] 471853006180 substrate interaction site [chemical binding]; other site 471853006181 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471853006182 short chain dehydrogenase; Provisional; Region: PRK06114 471853006183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006184 NAD(P) binding site [chemical binding]; other site 471853006185 active site 471853006186 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853006187 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471853006188 dimer interface [polypeptide binding]; other site 471853006189 active site 471853006190 catalytic residue [active] 471853006191 GTP-binding protein Der; Reviewed; Region: PRK03003 471853006192 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 471853006193 G1 box; other site 471853006194 GTP/Mg2+ binding site [chemical binding]; other site 471853006195 Switch I region; other site 471853006196 G2 box; other site 471853006197 Switch II region; other site 471853006198 G3 box; other site 471853006199 G4 box; other site 471853006200 G5 box; other site 471853006201 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 471853006202 G1 box; other site 471853006203 GTP/Mg2+ binding site [chemical binding]; other site 471853006204 Switch I region; other site 471853006205 G2 box; other site 471853006206 G3 box; other site 471853006207 Switch II region; other site 471853006208 G4 box; other site 471853006209 G5 box; other site 471853006210 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471853006211 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 471853006212 putative acyl-acceptor binding pocket; other site 471853006213 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 471853006214 CMP-binding site; other site 471853006215 The sites determining sugar specificity; other site 471853006216 prephenate dehydrogenase; Validated; Region: PRK06545 471853006217 prephenate dehydrogenase; Validated; Region: PRK08507 471853006218 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471853006219 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 471853006220 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471853006221 RNA binding surface [nucleotide binding]; other site 471853006222 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 471853006223 active site 471853006224 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 471853006225 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 471853006226 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471853006227 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853006228 P-loop; other site 471853006229 Magnesium ion binding site [ion binding]; other site 471853006230 transport-energizing ATPase, TRC40/GET3/ArsA family; Region: GET3_arsA_TRC40; TIGR00345 471853006231 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853006232 Magnesium ion binding site [ion binding]; other site 471853006233 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 471853006234 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 471853006235 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 471853006236 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471853006237 active site 471853006238 DNA binding site [nucleotide binding] 471853006239 Int/Topo IB signature motif; other site 471853006240 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 471853006241 UbiA prenyltransferase family; Region: UbiA; pfam01040 471853006242 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 471853006243 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 471853006244 TPP-binding site [chemical binding]; other site 471853006245 dimer interface [polypeptide binding]; other site 471853006246 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 471853006247 PYR/PP interface [polypeptide binding]; other site 471853006248 dimer interface [polypeptide binding]; other site 471853006249 TPP binding site [chemical binding]; other site 471853006250 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471853006251 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 471853006252 putative active site [active] 471853006253 catalytic residue [active] 471853006254 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 471853006255 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 471853006256 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 471853006257 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 471853006258 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 471853006259 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471853006260 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 471853006261 putative active site [active] 471853006262 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471853006263 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853006264 S-adenosylmethionine binding site [chemical binding]; other site 471853006265 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 471853006266 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 471853006267 triosephosphate isomerase; Provisional; Region: PRK14565 471853006268 substrate binding site [chemical binding]; other site 471853006269 dimer interface [polypeptide binding]; other site 471853006270 catalytic triad [active] 471853006271 Phosphoglycerate kinase; Region: PGK; pfam00162 471853006272 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 471853006273 substrate binding site [chemical binding]; other site 471853006274 hinge regions; other site 471853006275 ADP binding site [chemical binding]; other site 471853006276 catalytic site [active] 471853006277 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 471853006278 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 471853006279 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 471853006280 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 471853006281 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 471853006282 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 471853006283 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 471853006284 phosphate binding site [ion binding]; other site 471853006285 putative substrate binding pocket [chemical binding]; other site 471853006286 dimer interface [polypeptide binding]; other site 471853006287 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 471853006288 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 471853006289 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471853006290 GIY-YIG motif/motif A; other site 471853006291 active site 471853006292 catalytic site [active] 471853006293 putative DNA binding site [nucleotide binding]; other site 471853006294 metal binding site [ion binding]; metal-binding site 471853006295 UvrB/uvrC motif; Region: UVR; pfam02151 471853006296 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 471853006297 Helix-hairpin-helix motif; Region: HHH; pfam00633 471853006298 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 471853006299 putative catalytic site [active] 471853006300 putative metal binding site [ion binding]; other site 471853006301 putative phosphate binding site [ion binding]; other site 471853006302 OsmC-like protein; Region: OsmC; cl00767 471853006303 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 471853006304 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471853006305 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 471853006306 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 471853006307 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 471853006308 MOSC domain; Region: MOSC; pfam03473 471853006309 YCII-related domain; Region: YCII; cl00999 471853006310 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 471853006311 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 471853006312 Integral membrane protein TerC family; Region: TerC; cl10468 471853006313 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 471853006314 excinuclease ABC subunit B; Provisional; Region: PRK05298 471853006315 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853006316 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853006317 nucleotide binding region [chemical binding]; other site 471853006318 ATP-binding site [chemical binding]; other site 471853006319 Ultra-violet resistance protein B; Region: UvrB; pfam12344 471853006320 UvrB/uvrC motif; Region: UVR; pfam02151 471853006321 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 471853006322 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471853006323 active site 471853006324 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 471853006325 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 471853006326 CoA-binding site [chemical binding]; other site 471853006327 ATP-binding [chemical binding]; other site 471853006328 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 471853006329 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853006330 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853006331 active site 471853006332 phosphorylation site [posttranslational modification] 471853006333 intermolecular recognition site; other site 471853006334 dimerization interface [polypeptide binding]; other site 471853006335 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853006336 DNA binding residues [nucleotide binding] 471853006337 dimerization interface [polypeptide binding]; other site 471853006338 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853006339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853006340 ATP binding site [chemical binding]; other site 471853006341 Mg2+ binding site [ion binding]; other site 471853006342 G-X-G motif; other site 471853006343 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 471853006344 putative substrate binding pocket [chemical binding]; other site 471853006345 AC domain interface; other site 471853006346 catalytic triad [active] 471853006347 AB domain interface; other site 471853006348 interchain disulfide; other site 471853006349 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471853006350 active site 471853006351 ADP-ribose binding site [chemical binding]; other site 471853006352 dimer interface [polypeptide binding]; other site 471853006353 nudix motif; other site 471853006354 metal binding site [ion binding]; metal-binding site 471853006355 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 471853006356 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 471853006357 RNA binding site [nucleotide binding]; other site 471853006358 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 471853006359 RNA binding site [nucleotide binding]; other site 471853006360 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 471853006361 RNA binding site [nucleotide binding]; other site 471853006362 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 471853006363 RNA binding site [nucleotide binding]; other site 471853006364 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853006365 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853006366 Walker A/P-loop; other site 471853006367 ATP binding site [chemical binding]; other site 471853006368 Q-loop/lid; other site 471853006369 ABC transporter signature motif; other site 471853006370 Walker B; other site 471853006371 D-loop; other site 471853006372 H-loop/switch region; other site 471853006373 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853006374 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853006375 Walker A/P-loop; other site 471853006376 ATP binding site [chemical binding]; other site 471853006377 Q-loop/lid; other site 471853006378 ABC transporter signature motif; other site 471853006379 Walker B; other site 471853006380 D-loop; other site 471853006381 H-loop/switch region; other site 471853006382 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853006383 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853006384 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006385 putative PBP binding loops; other site 471853006386 dimer interface [polypeptide binding]; other site 471853006387 ABC-ATPase subunit interface; other site 471853006388 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853006389 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006390 dimer interface [polypeptide binding]; other site 471853006391 conserved gate region; other site 471853006392 putative PBP binding loops; other site 471853006393 ABC-ATPase subunit interface; other site 471853006394 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 471853006395 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853006396 peptide binding site [polypeptide binding]; other site 471853006397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853006398 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 471853006399 DNA polymerase I; Provisional; Region: PRK05755 471853006400 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471853006401 active site 471853006402 metal binding site 1 [ion binding]; metal-binding site 471853006403 putative 5' ssDNA interaction site; other site 471853006404 metal binding site 3; metal-binding site 471853006405 metal binding site 2 [ion binding]; metal-binding site 471853006406 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471853006407 putative DNA binding site [nucleotide binding]; other site 471853006408 putative metal binding site [ion binding]; other site 471853006409 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 471853006410 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 471853006411 active site 471853006412 DNA binding site [nucleotide binding] 471853006413 catalytic site [active] 471853006414 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 471853006415 CoenzymeA binding site [chemical binding]; other site 471853006416 subunit interaction site [polypeptide binding]; other site 471853006417 PHB binding site; other site 471853006418 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 471853006419 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 471853006420 TM-ABC transporter signature motif; other site 471853006421 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 471853006422 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 471853006423 TM-ABC transporter signature motif; other site 471853006424 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 471853006425 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 471853006426 Walker A/P-loop; other site 471853006427 ATP binding site [chemical binding]; other site 471853006428 Q-loop/lid; other site 471853006429 ABC transporter signature motif; other site 471853006430 Walker B; other site 471853006431 D-loop; other site 471853006432 H-loop/switch region; other site 471853006433 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 471853006434 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 471853006435 Walker A/P-loop; other site 471853006436 ATP binding site [chemical binding]; other site 471853006437 Q-loop/lid; other site 471853006438 ABC transporter signature motif; other site 471853006439 Walker B; other site 471853006440 D-loop; other site 471853006441 H-loop/switch region; other site 471853006442 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 471853006443 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 471853006444 ligand binding site [chemical binding]; other site 471853006445 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 471853006446 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853006447 active site 471853006448 phosphorylation site [posttranslational modification] 471853006449 intermolecular recognition site; other site 471853006450 dimerization interface [polypeptide binding]; other site 471853006451 ANTAR domain; Region: ANTAR; pfam03861 471853006452 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853006453 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853006454 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853006455 DNA binding residues [nucleotide binding] 471853006456 YCII-related domain; Region: YCII; cl00999 471853006457 Catalytic domain of Protein Kinases; Region: PKc; cd00180 471853006458 active site 471853006459 ATP binding site [chemical binding]; other site 471853006460 substrate binding site [chemical binding]; other site 471853006461 activation loop (A-loop); other site 471853006462 type VII secretion-associated protein, Rv3446c family, C-terminal domain; Region: T7SS_Rv3446c; TIGR03931 471853006463 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 471853006464 pyruvate kinase; Provisional; Region: PRK06247 471853006465 domain interfaces; other site 471853006466 active site 471853006467 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 471853006468 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471853006469 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 471853006470 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 471853006471 active site 471853006472 dimer interface [polypeptide binding]; other site 471853006473 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 471853006474 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 471853006475 active site 471853006476 FMN binding site [chemical binding]; other site 471853006477 substrate binding site [chemical binding]; other site 471853006478 3Fe-4S cluster binding site [ion binding]; other site 471853006479 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 471853006480 domain interface; other site 471853006481 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 471853006482 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 471853006483 substrate binding site [chemical binding]; other site 471853006484 active site 471853006485 catalytic residues [active] 471853006486 heterodimer interface [polypeptide binding]; other site 471853006487 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 471853006488 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 471853006489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853006490 catalytic residue [active] 471853006491 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 471853006492 active site 471853006493 ribulose/triose binding site [chemical binding]; other site 471853006494 phosphate binding site [ion binding]; other site 471853006495 substrate (anthranilate) binding pocket [chemical binding]; other site 471853006496 product (indole) binding pocket [chemical binding]; other site 471853006497 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 471853006498 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 471853006499 anthranilate synthase component I; Provisional; Region: PRK13571 471853006500 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 471853006501 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471853006502 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 471853006503 TIGR03085 family protein; Region: TIGR03085 471853006504 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853006505 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853006506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006507 Walker A/P-loop; other site 471853006508 ATP binding site [chemical binding]; other site 471853006509 Q-loop/lid; other site 471853006510 ABC transporter signature motif; other site 471853006511 Walker B; other site 471853006512 D-loop; other site 471853006513 H-loop/switch region; other site 471853006514 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853006515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006516 Walker A/P-loop; other site 471853006517 ATP binding site [chemical binding]; other site 471853006518 Q-loop/lid; other site 471853006519 ABC transporter signature motif; other site 471853006520 Walker B; other site 471853006521 D-loop; other site 471853006522 H-loop/switch region; other site 471853006523 OsmC-like protein; Region: OsmC; cl00767 471853006524 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 471853006525 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853006526 putative NAD(P) binding site [chemical binding]; other site 471853006527 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471853006528 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853006529 non-specific DNA binding site [nucleotide binding]; other site 471853006530 salt bridge; other site 471853006531 sequence-specific DNA binding site [nucleotide binding]; other site 471853006532 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 471853006533 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 471853006534 substrate binding site [chemical binding]; other site 471853006535 glutamase interaction surface [polypeptide binding]; other site 471853006536 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471853006537 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 471853006538 active site 471853006539 proteasome accessory factor PafA; Region: pupylate_PafA; TIGR03686 471853006540 proteasome, beta subunit, bacterial type; Region: 20S_bact_beta; TIGR03690 471853006541 proteasome_protease_HslV. This group contains the eukaryotic proteosome alpha and beta subunits and the prokaryotic protease hslV subunit. Proteasomes are large multimeric self-compartmentalizing proteases, involved in the clearance of misfolded proteins; Region: proteasome_protease_HslV; cd01906 471853006542 active site 471853006543 Pup-like protein; Region: Pup; pfam05639 471853006544 Pup-ligase protein; Region: Pup_ligase; cl15463 471853006545 proteasome ATPase; Region: pup_AAA; TIGR03689 471853006546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853006547 Walker B motif; other site 471853006548 arginine finger; other site 471853006549 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 471853006550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471853006551 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 471853006552 active site 471853006553 putative substrate binding region [chemical binding]; other site 471853006554 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 471853006555 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853006556 motif II; other site 471853006557 PAC2 family; Region: PAC2; pfam09754 471853006558 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853006559 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 471853006560 active site 471853006561 HIGH motif; other site 471853006562 nucleotide binding site [chemical binding]; other site 471853006563 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853006564 active site 471853006565 KMSKS motif; other site 471853006566 Mycobacterium tuberculosis CorA-like subfamily; Region: MtCorA-like; cd12830 471853006567 oligomer interface [polypeptide binding]; other site 471853006568 metal binding site [ion binding]; metal-binding site 471853006569 metal binding site [ion binding]; metal-binding site 471853006570 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 471853006571 putative Cl binding site [ion binding]; other site 471853006572 basic sphincter; other site 471853006573 hydrophobic gate; other site 471853006574 periplasmic entrance; other site 471853006575 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 471853006576 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853006577 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853006578 active site 471853006579 catalytic tetrad [active] 471853006580 hypothetical protein; Provisional; Region: PRK07906 471853006581 M20 Peptidase, carboxypeptidase yscS-like; Region: M20_yscS_like; cd05675 471853006582 putative metal binding site [ion binding]; other site 471853006583 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 471853006584 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 471853006585 active site 471853006586 Zn binding site [ion binding]; other site 471853006587 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471853006588 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 471853006589 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 471853006590 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471853006591 MFS/sugar transport protein; Region: MFS_2; pfam13347 471853006592 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 471853006593 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471853006594 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 471853006595 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853006596 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853006597 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853006598 DNA binding site [nucleotide binding] 471853006599 domain linker motif; other site 471853006600 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853006601 dimerization interface [polypeptide binding]; other site 471853006602 ligand binding site [chemical binding]; other site 471853006603 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853006604 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853006605 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006606 putative PBP binding loops; other site 471853006607 dimer interface [polypeptide binding]; other site 471853006608 ABC-ATPase subunit interface; other site 471853006609 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853006610 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006611 dimer interface [polypeptide binding]; other site 471853006612 conserved gate region; other site 471853006613 putative PBP binding loops; other site 471853006614 ABC-ATPase subunit interface; other site 471853006615 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 471853006616 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853006617 putative NAD(P) binding site [chemical binding]; other site 471853006618 catalytic Zn binding site [ion binding]; other site 471853006619 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853006620 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853006621 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471853006622 Peptidase family M23; Region: Peptidase_M23; pfam01551 471853006623 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 471853006624 active site 471853006625 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853006626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006627 dimer interface [polypeptide binding]; other site 471853006628 conserved gate region; other site 471853006629 putative PBP binding loops; other site 471853006630 ABC-ATPase subunit interface; other site 471853006631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853006632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006633 putative PBP binding loops; other site 471853006634 ABC-ATPase subunit interface; other site 471853006635 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853006636 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853006637 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853006638 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853006639 DNA binding site [nucleotide binding] 471853006640 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853006641 ligand binding site [chemical binding]; other site 471853006642 dimerization interface [polypeptide binding]; other site 471853006643 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 471853006644 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 471853006645 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 471853006646 Predicted ATPase [General function prediction only]; Region: COG4637 471853006647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006648 Walker A/P-loop; other site 471853006649 ATP binding site [chemical binding]; other site 471853006650 Q-loop/lid; other site 471853006651 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 471853006652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 471853006653 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471853006654 motif I; other site 471853006655 active site 471853006656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853006657 motif II; other site 471853006658 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 471853006659 Phosphotransferase enzyme family; Region: APH; pfam01636 471853006660 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471853006661 Domain of unknown function DUF20; Region: UPF0118; pfam01594 471853006662 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 471853006663 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 471853006664 active site 471853006665 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06920 471853006666 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471853006667 generic binding surface I; other site 471853006668 generic binding surface II; other site 471853006669 Y-family of DNA polymerases; Region: PolY; cl12025 471853006670 active site 471853006671 DNA binding site [nucleotide binding] 471853006672 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 471853006673 substrate binding site [chemical binding]; other site 471853006674 PA2301 is an uncharacterized Pseudomonas aeruginosa protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's...; Region: PA2301; cd04939 471853006675 putative deacylase active site [active] 471853006676 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471853006677 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853006678 FAD binding pocket [chemical binding]; other site 471853006679 FAD binding motif [chemical binding]; other site 471853006680 phosphate binding motif [ion binding]; other site 471853006681 NAD binding pocket [chemical binding]; other site 471853006682 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471853006683 FecCD transport family; Region: FecCD; pfam01032 471853006684 FecCD transport family; Region: FecCD; pfam01032 471853006685 ABC-ATPase subunit interface; other site 471853006686 dimer interface [polypeptide binding]; other site 471853006687 putative PBP binding regions; other site 471853006688 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 471853006689 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471853006690 siderophore binding site; other site 471853006691 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471853006692 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471853006693 Walker A/P-loop; other site 471853006694 ATP binding site [chemical binding]; other site 471853006695 Q-loop/lid; other site 471853006696 ABC transporter signature motif; other site 471853006697 Walker B; other site 471853006698 D-loop; other site 471853006699 H-loop/switch region; other site 471853006700 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471853006701 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 471853006702 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853006703 homotrimer interaction site [polypeptide binding]; other site 471853006704 putative active site [active] 471853006705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853006706 dimer interface [polypeptide binding]; other site 471853006707 conserved gate region; other site 471853006708 ABC-ATPase subunit interface; other site 471853006709 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 471853006710 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 471853006711 Walker A/P-loop; other site 471853006712 ATP binding site [chemical binding]; other site 471853006713 Q-loop/lid; other site 471853006714 ABC transporter signature motif; other site 471853006715 Walker B; other site 471853006716 D-loop; other site 471853006717 H-loop/switch region; other site 471853006718 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 471853006719 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 471853006720 hypothetical protein; Provisional; Region: PRK07236 471853006721 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 471853006722 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853006723 MarR family; Region: MarR_2; cl17246 471853006724 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853006725 Coenzyme A binding pocket [chemical binding]; other site 471853006726 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471853006727 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471853006728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853006729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853006730 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 471853006731 Protein of unknown function (DUF998); Region: DUF998; pfam06197 471853006732 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853006733 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853006734 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 471853006735 Walker A/P-loop; other site 471853006736 ATP binding site [chemical binding]; other site 471853006737 Q-loop/lid; other site 471853006738 ABC transporter signature motif; other site 471853006739 Walker B; other site 471853006740 D-loop; other site 471853006741 H-loop/switch region; other site 471853006742 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853006743 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853006744 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006745 Walker A/P-loop; other site 471853006746 ATP binding site [chemical binding]; other site 471853006747 Q-loop/lid; other site 471853006748 ABC transporter signature motif; other site 471853006749 Walker B; other site 471853006750 D-loop; other site 471853006751 H-loop/switch region; other site 471853006752 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 471853006753 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 471853006754 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 471853006755 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 471853006756 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006757 Walker A/P-loop; other site 471853006758 ATP binding site [chemical binding]; other site 471853006759 ABC transporter signature motif; other site 471853006760 Walker B; other site 471853006761 D-loop; other site 471853006762 H-loop/switch region; other site 471853006763 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 471853006764 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 471853006765 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 471853006766 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 471853006767 ligand binding site; other site 471853006768 oligomer interface; other site 471853006769 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 471853006770 sulfate 1 binding site; other site 471853006771 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853006772 motif II; other site 471853006773 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853006774 catalytic core [active] 471853006775 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07889 471853006776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006777 NAD(P) binding site [chemical binding]; other site 471853006778 active site 471853006779 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006780 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 471853006781 NAD(P) binding site [chemical binding]; other site 471853006782 active site 471853006783 Protein of unknown function (DUF3099); Region: DUF3099; pfam11298 471853006784 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 471853006785 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853006786 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006787 Walker A/P-loop; other site 471853006788 ATP binding site [chemical binding]; other site 471853006789 Q-loop/lid; other site 471853006790 ABC transporter signature motif; other site 471853006791 Walker B; other site 471853006792 D-loop; other site 471853006793 H-loop/switch region; other site 471853006794 ABC transporter; Region: ABC_tran_2; pfam12848 471853006795 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853006796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853006797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853006798 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 471853006799 putative dimer interface [polypeptide binding]; other site 471853006800 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471853006801 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471853006802 BioY family; Region: BioY; pfam02632 471853006803 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 471853006804 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853006805 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853006806 active site 471853006807 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 471853006808 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 471853006809 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 471853006810 trimerization site [polypeptide binding]; other site 471853006811 active site 471853006812 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 471853006813 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 471853006814 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853006815 catalytic residue [active] 471853006816 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 471853006817 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 471853006818 Walker A/P-loop; other site 471853006819 ATP binding site [chemical binding]; other site 471853006820 Q-loop/lid; other site 471853006821 ABC transporter signature motif; other site 471853006822 Walker B; other site 471853006823 D-loop; other site 471853006824 H-loop/switch region; other site 471853006825 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 471853006826 [2Fe-2S] cluster binding site [ion binding]; other site 471853006827 FeS assembly protein SufD; Region: sufD; TIGR01981 471853006828 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 471853006829 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 471853006830 FeS assembly protein SufB; Region: sufB; TIGR01980 471853006831 Predicted transcriptional regulator [Transcription]; Region: COG2345 471853006832 HTH domain; Region: HTH_11; cl17392 471853006833 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853006834 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853006835 Walker A/P-loop; other site 471853006836 ATP binding site [chemical binding]; other site 471853006837 Q-loop/lid; other site 471853006838 ABC transporter signature motif; other site 471853006839 Walker B; other site 471853006840 D-loop; other site 471853006841 H-loop/switch region; other site 471853006842 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471853006843 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853006844 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471853006845 NAD(P) binding site [chemical binding]; other site 471853006846 active site 471853006847 Domain of unknown function (DUF1772); Region: DUF1772; pfam08592 471853006848 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 471853006849 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 471853006850 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 471853006851 dimer interface [polypeptide binding]; other site 471853006852 ADP-ribose binding site [chemical binding]; other site 471853006853 active site 471853006854 nudix motif; other site 471853006855 metal binding site [ion binding]; metal-binding site 471853006856 CTP synthetase; Validated; Region: pyrG; PRK05380 471853006857 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 471853006858 Catalytic site [active] 471853006859 active site 471853006860 UTP binding site [chemical binding]; other site 471853006861 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 471853006862 active site 471853006863 putative oxyanion hole; other site 471853006864 catalytic triad [active] 471853006865 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853006866 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853006867 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 471853006868 Protein of unknown function (DUF3186); Region: DUF3186; pfam11382 471853006869 Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4825 471853006870 Thiamine pyrophosphokinase; Region: TPK; cl08415 471853006871 Thiamine pyrophosphokinase C terminal; Region: TPPK_C; pfam12555 471853006872 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 471853006873 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006874 Walker A/P-loop; other site 471853006875 ATP binding site [chemical binding]; other site 471853006876 Q-loop/lid; other site 471853006877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853006878 ABC transporter signature motif; other site 471853006879 Walker B; other site 471853006880 D-loop; other site 471853006881 H-loop/switch region; other site 471853006882 NAD kinase [Coenzyme metabolism]; Region: nadF; cl01255 471853006883 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 471853006884 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 471853006885 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471853006886 RNA binding surface [nucleotide binding]; other site 471853006887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853006888 S-adenosylmethionine binding site [chemical binding]; other site 471853006889 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471853006890 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 471853006891 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 471853006892 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 471853006893 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 471853006894 active site 471853006895 HIGH motif; other site 471853006896 dimer interface [polypeptide binding]; other site 471853006897 KMSKS motif; other site 471853006898 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471853006899 RNA binding surface [nucleotide binding]; other site 471853006900 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 471853006901 active site 471853006902 DNA binding site [nucleotide binding] 471853006903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853006904 S-adenosylmethionine binding site [chemical binding]; other site 471853006905 hypothetical protein; Provisional; Region: PRK06547 471853006906 argininosuccinate lyase; Provisional; Region: PRK00855 471853006907 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 471853006908 active sites [active] 471853006909 tetramer interface [polypeptide binding]; other site 471853006910 argininosuccinate synthase; Provisional; Region: PRK13820 471853006911 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 471853006912 ANP binding site [chemical binding]; other site 471853006913 Substrate Binding Site II [chemical binding]; other site 471853006914 Substrate Binding Site I [chemical binding]; other site 471853006915 arginine repressor; Provisional; Region: PRK03341 471853006916 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 471853006917 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 471853006918 ornithine carbamoyltransferase; Provisional; Region: PRK00779 471853006919 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 471853006920 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 471853006921 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 471853006922 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471853006923 inhibitor-cofactor binding pocket; inhibition site 471853006924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853006925 catalytic residue [active] 471853006926 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 471853006927 feedback inhibition sensing region; other site 471853006928 homohexameric interface [polypeptide binding]; other site 471853006929 nucleotide binding site [chemical binding]; other site 471853006930 N-acetyl-L-glutamate binding site [chemical binding]; other site 471853006931 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 471853006932 heterotetramer interface [polypeptide binding]; other site 471853006933 active site pocket [active] 471853006934 cleavage site 471853006935 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 471853006936 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 471853006937 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 471853006938 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 471853006939 NADP binding site [chemical binding]; other site 471853006940 dimer interface [polypeptide binding]; other site 471853006941 Flavodoxin domain; Region: Flavodoxin_5; cl17428 471853006942 classical (c) SDRs; Region: SDR_c; cd05233 471853006943 NAD(P) binding site [chemical binding]; other site 471853006944 active site 471853006945 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 471853006946 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 471853006947 putative tRNA-binding site [nucleotide binding]; other site 471853006948 B3/4 domain; Region: B3_4; pfam03483 471853006949 tRNA synthetase B5 domain; Region: B5; cl08394 471853006950 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471853006951 motif 1; other site 471853006952 dimer interface [polypeptide binding]; other site 471853006953 active site 471853006954 motif 2; other site 471853006955 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 471853006956 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 471853006957 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 471853006958 dimer interface [polypeptide binding]; other site 471853006959 motif 1; other site 471853006960 active site 471853006961 motif 2; other site 471853006962 motif 3; other site 471853006963 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 471853006964 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853006965 active site 471853006966 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471853006967 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471853006968 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 471853006969 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 471853006970 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 471853006971 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 471853006972 23S rRNA binding site [nucleotide binding]; other site 471853006973 L21 binding site [polypeptide binding]; other site 471853006974 L13 binding site [polypeptide binding]; other site 471853006975 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 471853006976 translation initiation factor IF-3; Region: infC; TIGR00168 471853006977 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 471853006978 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 471853006979 Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596 471853006980 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 471853006981 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 471853006982 catalytic residues [active] 471853006983 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 471853006984 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 471853006985 putative active site [active] 471853006986 oxyanion strand; other site 471853006987 catalytic triad [active] 471853006988 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 471853006989 putative active site pocket [active] 471853006990 4-fold oligomerization interface [polypeptide binding]; other site 471853006991 metal binding residues [ion binding]; metal-binding site 471853006992 3-fold/trimer interface [polypeptide binding]; other site 471853006993 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 471853006994 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853006995 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853006996 homodimer interface [polypeptide binding]; other site 471853006997 catalytic residue [active] 471853006998 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 471853006999 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853007000 ATP binding site [chemical binding]; other site 471853007001 putative Mg++ binding site [ion binding]; other site 471853007002 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853007003 nucleotide binding region [chemical binding]; other site 471853007004 ATP-binding site [chemical binding]; other site 471853007005 PspC domain; Region: PspC; cl00864 471853007006 AAA domain; Region: AAA_17; pfam13207 471853007007 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 471853007008 histidinol dehydrogenase; Region: hisD; TIGR00069 471853007009 NAD binding site [chemical binding]; other site 471853007010 dimerization interface [polypeptide binding]; other site 471853007011 product binding site; other site 471853007012 substrate binding site [chemical binding]; other site 471853007013 zinc binding site [ion binding]; other site 471853007014 catalytic residues [active] 471853007015 S4 domain; Region: S4_2; pfam13275 471853007016 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_24; cd04683 471853007017 nudix motif; other site 471853007018 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 471853007019 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 471853007020 active site 471853007021 PHP Thumb interface [polypeptide binding]; other site 471853007022 metal binding site [ion binding]; metal-binding site 471853007023 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 471853007024 generic binding surface II; other site 471853007025 generic binding surface I; other site 471853007026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853007027 Coenzyme A binding pocket [chemical binding]; other site 471853007028 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 471853007029 active site 471853007030 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 471853007031 DivIVA protein; Region: DivIVA; pfam05103 471853007032 DivIVA domain; Region: DivI1A_domain; TIGR03544 471853007033 YGGT family; Region: YGGT; cl00508 471853007034 Protein of unknown function (DUF552); Region: DUF552; pfam04472 471853007035 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 471853007036 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 471853007037 cell division protein FtsZ; Validated; Region: PRK09330 471853007038 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 471853007039 nucleotide binding site [chemical binding]; other site 471853007040 SulA interaction site; other site 471853007041 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 471853007042 Cell division protein FtsQ; Region: FtsQ; pfam03799 471853007043 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 471853007044 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471853007045 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471853007046 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471853007047 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 471853007048 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 471853007049 active site 471853007050 homodimer interface [polypeptide binding]; other site 471853007051 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 471853007052 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 471853007053 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471853007054 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 471853007055 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 471853007056 Mg++ binding site [ion binding]; other site 471853007057 putative catalytic motif [active] 471853007058 putative substrate binding site [chemical binding]; other site 471853007059 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 471853007060 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 471853007061 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471853007062 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471853007063 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 471853007064 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 471853007065 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471853007066 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 471853007067 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 471853007068 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471853007069 MraW methylase family; Region: Methyltransf_5; cl17771 471853007070 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 471853007071 cell division protein MraZ; Reviewed; Region: PRK00326 471853007072 MraZ protein; Region: MraZ; pfam02381 471853007073 MraZ protein; Region: MraZ; pfam02381 471853007074 MoxR-like ATPases [General function prediction only]; Region: COG0714 471853007075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853007076 ATP binding site [chemical binding]; other site 471853007077 Walker A motif; other site 471853007078 Walker B motif; other site 471853007079 arginine finger; other site 471853007080 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471853007081 Protein of unknown function DUF58; Region: DUF58; pfam01882 471853007082 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471853007083 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471853007084 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 471853007085 DNA polymerase IV; Validated; Region: PRK03858 471853007086 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 471853007087 active site 471853007088 DNA binding site [nucleotide binding] 471853007089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471853007090 S-adenosylmethionine binding site [chemical binding]; other site 471853007091 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 471853007092 DNA-binding site [nucleotide binding]; DNA binding site 471853007093 RNA-binding motif; other site 471853007094 PAC2 family; Region: PAC2; pfam09754 471853007095 Part of AAA domain; Region: AAA_19; pfam13245 471853007096 Family description; Region: UvrD_C_2; pfam13538 471853007097 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 471853007098 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 471853007099 ligand binding site [chemical binding]; other site 471853007100 NAD binding site [chemical binding]; other site 471853007101 tetramer interface [polypeptide binding]; other site 471853007102 catalytic site [active] 471853007103 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 471853007104 L-serine binding site [chemical binding]; other site 471853007105 ACT domain interface; other site 471853007106 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 471853007107 ATP cone domain; Region: ATP-cone; pfam03477 471853007108 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 471853007109 LexA repressor; Validated; Region: PRK00215 471853007110 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 471853007111 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 471853007112 Catalytic site [active] 471853007113 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 471853007114 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 471853007115 NAD binding site [chemical binding]; other site 471853007116 dimer interface [polypeptide binding]; other site 471853007117 substrate binding site [chemical binding]; other site 471853007118 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471853007119 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 471853007120 DEAD/DEAH box helicase; Region: DEAD; pfam00270 471853007121 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 471853007122 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 471853007123 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 471853007124 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 471853007125 HflX GTPase family; Region: HflX; cd01878 471853007126 G1 box; other site 471853007127 GTP/Mg2+ binding site [chemical binding]; other site 471853007128 Switch I region; other site 471853007129 G2 box; other site 471853007130 G3 box; other site 471853007131 Switch II region; other site 471853007132 G4 box; other site 471853007133 G5 box; other site 471853007134 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 471853007135 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853007136 S-adenosylmethionine binding site [chemical binding]; other site 471853007137 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471853007138 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 471853007139 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 471853007140 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 471853007141 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 471853007142 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 471853007143 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 471853007144 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 471853007145 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 471853007146 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471853007147 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 471853007148 Walker A/P-loop; other site 471853007149 ATP binding site [chemical binding]; other site 471853007150 Q-loop/lid; other site 471853007151 ABC transporter signature motif; other site 471853007152 Walker B; other site 471853007153 D-loop; other site 471853007154 H-loop/switch region; other site 471853007155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471853007156 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 471853007157 substrate binding pocket [chemical binding]; other site 471853007158 membrane-bound complex binding site; other site 471853007159 hinge residues; other site 471853007160 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007161 dimer interface [polypeptide binding]; other site 471853007162 conserved gate region; other site 471853007163 ABC-ATPase subunit interface; other site 471853007164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007165 dimer interface [polypeptide binding]; other site 471853007166 conserved gate region; other site 471853007167 putative PBP binding loops; other site 471853007168 ABC-ATPase subunit interface; other site 471853007169 recombination regulator RecX; Reviewed; Region: recX; PRK00117 471853007170 recombinase A; Provisional; Region: recA; PRK09354 471853007171 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 471853007172 hexamer interface [polypeptide binding]; other site 471853007173 Walker A motif; other site 471853007174 ATP binding site [chemical binding]; other site 471853007175 Walker B motif; other site 471853007176 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853007177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853007178 active site 471853007179 phosphorylation site [posttranslational modification] 471853007180 intermolecular recognition site; other site 471853007181 dimerization interface [polypeptide binding]; other site 471853007182 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853007183 DNA binding residues [nucleotide binding] 471853007184 dimerization interface [polypeptide binding]; other site 471853007185 Histidine kinase; Region: HisKA_3; pfam07730 471853007186 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853007187 Pectinacetylesterase; Region: PAE; pfam03283 471853007188 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 471853007189 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853007190 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 471853007191 ATP binding site [chemical binding]; other site 471853007192 putative Mg++ binding site [ion binding]; other site 471853007193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853007194 nucleotide binding region [chemical binding]; other site 471853007195 ATP-binding site [chemical binding]; other site 471853007196 DEAD/H associated; Region: DEAD_assoc; pfam08494 471853007197 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471853007198 N-terminal domain of the actinomycetal Nei2 and related DNA glycosylases; Region: AcNei2_N; cd08971 471853007199 putative DNA binding site [nucleotide binding]; other site 471853007200 catalytic residue [active] 471853007201 putative H2TH interface [polypeptide binding]; other site 471853007202 putative catalytic residues [active] 471853007203 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471853007204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853007205 non-specific DNA binding site [nucleotide binding]; other site 471853007206 salt bridge; other site 471853007207 sequence-specific DNA binding site [nucleotide binding]; other site 471853007208 Competence-damaged protein; Region: CinA; pfam02464 471853007209 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 471853007210 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 471853007211 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 471853007212 putative active site [active] 471853007213 putative metal binding site [ion binding]; other site 471853007214 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471853007215 Sulfatase; Region: Sulfatase; cl17466 471853007216 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853007217 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853007218 active site 471853007219 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 471853007220 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 471853007221 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471853007222 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 471853007223 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853007224 WHG domain; Region: WHG; pfam13305 471853007225 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 471853007226 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471853007227 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 471853007228 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853007229 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 471853007230 dimer interface [polypeptide binding]; other site 471853007231 active site 471853007232 catalytic residue [active] 471853007233 AzlC protein; Region: AzlC; pfam03591 471853007234 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853007235 Coenzyme A binding pocket [chemical binding]; other site 471853007236 hypothetical protein; Provisional; Region: PRK05208 471853007237 dihydrodipicolinate reductase; Provisional; Region: PRK00048 471853007238 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 471853007239 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 471853007240 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 471853007241 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 471853007242 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853007243 classical (c) SDRs; Region: SDR_c; cd05233 471853007244 NAD(P) binding site [chemical binding]; other site 471853007245 active site 471853007246 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853007247 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853007248 putative substrate translocation pore; other site 471853007249 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853007250 putative DNA binding site [nucleotide binding]; other site 471853007251 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 471853007252 putative Zn2+ binding site [ion binding]; other site 471853007253 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 471853007254 dimerization interface [polypeptide binding]; other site 471853007255 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 471853007256 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 471853007257 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 471853007258 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 471853007259 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 471853007260 oligomer interface [polypeptide binding]; other site 471853007261 RNA binding site [nucleotide binding]; other site 471853007262 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 471853007263 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 471853007264 RNase E interface [polypeptide binding]; other site 471853007265 trimer interface [polypeptide binding]; other site 471853007266 active site 471853007267 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 471853007268 putative nucleic acid binding region [nucleotide binding]; other site 471853007269 G-X-X-G motif; other site 471853007270 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 471853007271 RNA binding site [nucleotide binding]; other site 471853007272 domain interface; other site 471853007273 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 471853007274 16S/18S rRNA binding site [nucleotide binding]; other site 471853007275 S13e-L30e interaction site [polypeptide binding]; other site 471853007276 25S rRNA binding site [nucleotide binding]; other site 471853007277 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471853007278 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853007279 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853007280 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853007281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853007282 active site 471853007283 phosphorylation site [posttranslational modification] 471853007284 intermolecular recognition site; other site 471853007285 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853007286 dimerization interface [polypeptide binding]; other site 471853007287 DNA binding residues [nucleotide binding] 471853007288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853007289 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853007290 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471853007291 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471853007292 FtsX-like permease family; Region: FtsX; pfam02687 471853007293 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853007294 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471853007295 Walker A/P-loop; other site 471853007296 ATP binding site [chemical binding]; other site 471853007297 Q-loop/lid; other site 471853007298 ABC transporter signature motif; other site 471853007299 Walker B; other site 471853007300 D-loop; other site 471853007301 H-loop/switch region; other site 471853007302 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 471853007303 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 471853007304 active site 471853007305 Riboflavin kinase; Region: Flavokinase; smart00904 471853007306 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 471853007307 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 471853007308 RNA binding site [nucleotide binding]; other site 471853007309 active site 471853007310 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 471853007311 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 471853007312 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471853007313 translation initiation factor IF-2; Region: IF-2; TIGR00487 471853007314 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 471853007315 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 471853007316 G1 box; other site 471853007317 putative GEF interaction site [polypeptide binding]; other site 471853007318 GTP/Mg2+ binding site [chemical binding]; other site 471853007319 Switch I region; other site 471853007320 G2 box; other site 471853007321 G3 box; other site 471853007322 Switch II region; other site 471853007323 G4 box; other site 471853007324 G5 box; other site 471853007325 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 471853007326 Translation-initiation factor 2; Region: IF-2; pfam11987 471853007327 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 471853007328 Protein of unknown function (DUF448); Region: DUF448; pfam04296 471853007329 putative RNA binding cleft [nucleotide binding]; other site 471853007330 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 471853007331 NusA N-terminal domain; Region: NusA_N; pfam08529 471853007332 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 471853007333 RNA binding site [nucleotide binding]; other site 471853007334 homodimer interface [polypeptide binding]; other site 471853007335 NusA-like KH domain; Region: KH_5; pfam13184 471853007336 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 471853007337 G-X-X-G motif; other site 471853007338 Sm and related proteins; Region: Sm_like; cl00259 471853007339 ribosome maturation protein RimP; Reviewed; Region: PRK00092 471853007340 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 471853007341 putative oligomer interface [polypeptide binding]; other site 471853007342 putative RNA binding site [nucleotide binding]; other site 471853007343 prolyl-tRNA synthetase; Provisional; Region: PRK09194 471853007344 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 471853007345 dimer interface [polypeptide binding]; other site 471853007346 motif 1; other site 471853007347 active site 471853007348 motif 2; other site 471853007349 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 471853007350 putative deacylase active site [active] 471853007351 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471853007352 active site 471853007353 motif 3; other site 471853007354 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 471853007355 anticodon binding site; other site 471853007356 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853007357 homotrimer interaction site [polypeptide binding]; other site 471853007358 putative active site [active] 471853007359 HTH domain; Region: HTH_11; pfam08279 471853007360 WYL domain; Region: WYL; pfam13280 471853007361 Domain of unknown function (DUF4081); Region: DUF4081; pfam13312 471853007362 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853007363 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 471853007364 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471853007365 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 471853007366 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 471853007367 Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750 471853007368 active site 471853007369 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 471853007370 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 471853007371 putative substrate binding region [chemical binding]; other site 471853007372 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 471853007373 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 471853007374 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 471853007375 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 471853007376 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 471853007377 DivIVA domain; Region: DivI1A_domain; TIGR03544 471853007378 DivIVA domain; Region: DivI1A_domain; TIGR03544 471853007379 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 471853007380 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 471853007381 FeS/SAM binding site; other site 471853007382 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 471853007383 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 471853007384 ribosome recycling factor; Reviewed; Region: frr; PRK00083 471853007385 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 471853007386 hinge region; other site 471853007387 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 471853007388 putative nucleotide binding site [chemical binding]; other site 471853007389 uridine monophosphate binding site [chemical binding]; other site 471853007390 homohexameric interface [polypeptide binding]; other site 471853007391 elongation factor Ts; Provisional; Region: tsf; PRK09377 471853007392 UBA/TS-N domain; Region: UBA; pfam00627 471853007393 Elongation factor TS; Region: EF_TS; pfam00889 471853007394 Elongation factor TS; Region: EF_TS; pfam00889 471853007395 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 471853007396 rRNA interaction site [nucleotide binding]; other site 471853007397 S8 interaction site; other site 471853007398 putative laminin-1 binding site; other site 471853007399 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471853007400 Peptidase family M23; Region: Peptidase_M23; pfam01551 471853007401 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 471853007402 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 471853007403 active site 471853007404 DNA binding site [nucleotide binding] 471853007405 Int/Topo IB signature motif; other site 471853007406 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471853007407 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 471853007408 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 471853007409 DNA protecting protein DprA; Region: dprA; TIGR00732 471853007410 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 471853007411 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 471853007412 catalytic residues [active] 471853007413 catalytic nucleophile [active] 471853007414 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 471853007415 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 471853007416 polymerase nucleotide-binding site; other site 471853007417 DNA-binding residues [nucleotide binding]; DNA binding site 471853007418 nucleotide binding site [chemical binding]; other site 471853007419 primase nucleotide-binding site [nucleotide binding]; other site 471853007420 AAA domain; Region: AAA_25; pfam13481 471853007421 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 471853007422 hypothetical protein; Reviewed; Region: PRK12497 471853007423 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 471853007424 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 471853007425 RNA/DNA hybrid binding site [nucleotide binding]; other site 471853007426 active site 471853007427 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 471853007428 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 471853007429 Catalytic site [active] 471853007430 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 471853007431 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 471853007432 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853007433 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 471853007434 RimM N-terminal domain; Region: RimM; pfam01782 471853007435 PRC-barrel domain; Region: PRC; pfam05239 471853007436 hypothetical protein; Provisional; Region: PRK02821 471853007437 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 471853007438 G-X-X-G motif; other site 471853007439 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 471853007440 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 471853007441 signal recognition particle protein; Provisional; Region: PRK10867 471853007442 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 471853007443 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 471853007444 P loop; other site 471853007445 GTP binding site [chemical binding]; other site 471853007446 Signal peptide binding domain; Region: SRP_SPB; pfam02978 471853007447 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 471853007448 metal binding triad; other site 471853007449 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 471853007450 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 471853007451 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 471853007452 Nitrogen regulatory protein P-II; Region: P-II; smart00938 471853007453 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 471853007454 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 471853007455 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471853007456 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471853007457 AAA domain; Region: AAA_23; pfam13476 471853007458 Walker A/P-loop; other site 471853007459 ATP binding site [chemical binding]; other site 471853007460 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 471853007461 ABC transporter signature motif; other site 471853007462 Walker B; other site 471853007463 D-loop; other site 471853007464 H-loop/switch region; other site 471853007465 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007466 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853007467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007468 dimer interface [polypeptide binding]; other site 471853007469 conserved gate region; other site 471853007470 putative PBP binding loops; other site 471853007471 ABC-ATPase subunit interface; other site 471853007472 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007474 dimer interface [polypeptide binding]; other site 471853007475 conserved gate region; other site 471853007476 putative PBP binding loops; other site 471853007477 ABC-ATPase subunit interface; other site 471853007478 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471853007479 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853007480 Walker A/P-loop; other site 471853007481 ATP binding site [chemical binding]; other site 471853007482 Q-loop/lid; other site 471853007483 ABC transporter signature motif; other site 471853007484 Walker B; other site 471853007485 D-loop; other site 471853007486 H-loop/switch region; other site 471853007487 TOBE domain; Region: TOBE_2; pfam08402 471853007488 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 471853007489 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 471853007490 active site 471853007491 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471853007492 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853007493 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 471853007494 active site 471853007495 multimer interface [polypeptide binding]; other site 471853007496 Protein of unknown function (DUF4233); Region: DUF4233; pfam14017 471853007497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853007498 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853007499 putative substrate translocation pore; other site 471853007500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853007501 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 471853007502 DAK2 domain; Region: Dak2; cl03685 471853007503 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853007504 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853007505 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471853007506 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853007507 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 471853007508 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 471853007509 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 471853007510 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471853007511 HIGH motif; other site 471853007512 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 471853007513 active site 471853007514 KMSKS motif; other site 471853007515 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 471853007516 tRNA binding surface [nucleotide binding]; other site 471853007517 anticodon binding site; other site 471853007518 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471853007519 nucleotide binding site/active site [active] 471853007520 HIT family signature motif; other site 471853007521 catalytic residue [active] 471853007522 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853007523 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853007524 active site 471853007525 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007526 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 471853007527 NAD(P) binding site [chemical binding]; other site 471853007528 active site 471853007529 hypothetical protein; Provisional; Region: PRK06062 471853007530 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 471853007531 inhibitor-cofactor binding pocket; inhibition site 471853007532 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853007533 catalytic residue [active] 471853007534 NMT1/THI5 like; Region: NMT1; pfam09084 471853007535 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 471853007536 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471853007537 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471853007538 Walker A/P-loop; other site 471853007539 ATP binding site [chemical binding]; other site 471853007540 Q-loop/lid; other site 471853007541 ABC transporter signature motif; other site 471853007542 Walker B; other site 471853007543 D-loop; other site 471853007544 H-loop/switch region; other site 471853007545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853007546 F420-dependent oxidoreductase, CPS_4043 family; Region: F420_CPS_4043; TIGR03842 471853007547 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853007548 phenylhydantoinase; Validated; Region: PRK08323 471853007549 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 471853007550 tetramer interface [polypeptide binding]; other site 471853007551 active site 471853007552 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 471853007553 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 471853007554 active site 471853007555 catalytic triad [active] 471853007556 dimer interface [polypeptide binding]; other site 471853007557 putative transporter; Provisional; Region: PRK11021 471853007558 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853007559 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853007560 active site 471853007561 catalytic tetrad [active] 471853007562 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 471853007563 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471853007564 intersubunit interface [polypeptide binding]; other site 471853007565 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 471853007566 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471853007567 ABC-ATPase subunit interface; other site 471853007568 dimer interface [polypeptide binding]; other site 471853007569 putative PBP binding regions; other site 471853007570 proposed F420-0 ABC transporter, ATP-binding protein; Region: F420-0_ABC_ATP; TIGR03873 471853007571 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 471853007572 Walker A/P-loop; other site 471853007573 ATP binding site [chemical binding]; other site 471853007574 Q-loop/lid; other site 471853007575 ABC transporter signature motif; other site 471853007576 Walker B; other site 471853007577 D-loop; other site 471853007578 H-loop/switch region; other site 471853007579 F420-0:Gamma-glutamyl ligase; Region: F420_ligase; cl00644 471853007580 probable non-F420 flavinoid oxidoreductase; Region: flavin_revert; TIGR03885 471853007581 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853007582 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 471853007583 NAD(P) binding site [chemical binding]; other site 471853007584 LDH/MDH dimer interface [polypeptide binding]; other site 471853007585 substrate binding site [chemical binding]; other site 471853007586 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853007587 Ribokinase-like subgroup A. Found in bacteria and archaea, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_A; cd01942 471853007588 substrate binding site [chemical binding]; other site 471853007589 ATP binding site [chemical binding]; other site 471853007590 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853007591 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853007592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007593 dimer interface [polypeptide binding]; other site 471853007594 conserved gate region; other site 471853007595 putative PBP binding loops; other site 471853007596 ABC-ATPase subunit interface; other site 471853007597 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007598 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007599 dimer interface [polypeptide binding]; other site 471853007600 conserved gate region; other site 471853007601 putative PBP binding loops; other site 471853007602 ABC-ATPase subunit interface; other site 471853007603 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 471853007604 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853007605 active site 471853007606 HIGH motif; other site 471853007607 nucleotide binding site [chemical binding]; other site 471853007608 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853007609 active site 471853007610 KMSKS motif; other site 471853007611 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 471853007612 tRNA binding surface [nucleotide binding]; other site 471853007613 anticodon binding site; other site 471853007614 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 471853007615 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 471853007616 acyl-activating enzyme (AAE) consensus motif; other site 471853007617 putative AMP binding site [chemical binding]; other site 471853007618 putative active site [active] 471853007619 putative CoA binding site [chemical binding]; other site 471853007620 chorismate mutase; Provisional; Region: PRK09239 471853007621 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 471853007622 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 471853007623 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 471853007624 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853007625 Walker A motif; other site 471853007626 ATP binding site [chemical binding]; other site 471853007627 Walker B motif; other site 471853007628 arginine finger; other site 471853007629 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 471853007630 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 471853007631 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471853007632 oligomer interface [polypeptide binding]; other site 471853007633 active site residues [active] 471853007634 Clp protease; Region: CLP_protease; pfam00574 471853007635 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471853007636 oligomer interface [polypeptide binding]; other site 471853007637 active site residues [active] 471853007638 trigger factor; Provisional; Region: tig; PRK01490 471853007639 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 471853007640 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 471853007641 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853007642 Sulfatase; Region: Sulfatase; cl17466 471853007643 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007645 dimer interface [polypeptide binding]; other site 471853007646 conserved gate region; other site 471853007647 putative PBP binding loops; other site 471853007648 ABC-ATPase subunit interface; other site 471853007649 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853007650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007651 putative PBP binding loops; other site 471853007652 dimer interface [polypeptide binding]; other site 471853007653 ABC-ATPase subunit interface; other site 471853007654 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007655 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853007656 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853007657 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853007658 DNA binding site [nucleotide binding] 471853007659 domain linker motif; other site 471853007660 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853007661 ligand binding site [chemical binding]; other site 471853007662 dimerization interface [polypeptide binding]; other site 471853007663 Cupin domain; Region: Cupin_2; pfam07883 471853007664 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 471853007665 hydrophobic ligand binding site; other site 471853007666 Phosphotransferase enzyme family; Region: APH; pfam01636 471853007667 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853007668 active site 471853007669 ATP binding site [chemical binding]; other site 471853007670 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 471853007671 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 471853007672 dimer interface [polypeptide binding]; other site 471853007673 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853007674 catalytic residue [active] 471853007675 Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762 471853007676 serine O-acetyltransferase; Region: cysE; TIGR01172 471853007677 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 471853007678 trimer interface [polypeptide binding]; other site 471853007679 active site 471853007680 substrate binding site [chemical binding]; other site 471853007681 CoA binding site [chemical binding]; other site 471853007682 Putative p-aminobenzoyl-glutamate transporter [Coenzyme metabolism]; Region: AbgT; COG2978 471853007683 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 471853007684 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471853007685 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471853007686 interface (dimer of trimers) [polypeptide binding]; other site 471853007687 Substrate-binding/catalytic site; other site 471853007688 Zn-binding sites [ion binding]; other site 471853007689 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 471853007690 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471853007691 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 471853007692 putative DNA binding site [nucleotide binding]; other site 471853007693 catalytic residue [active] 471853007694 putative H2TH interface [polypeptide binding]; other site 471853007695 putative catalytic residues [active] 471853007696 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471853007697 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471853007698 DNA binding site [nucleotide binding] 471853007699 active site 471853007700 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471853007701 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471853007702 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 471853007703 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 471853007704 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 471853007705 active site 471853007706 Zn binding site [ion binding]; other site 471853007707 PQQ-like domain; Region: PQQ_2; pfam13360 471853007708 PQQ-like domain; Region: PQQ_2; pfam13360 471853007709 hypothetical protein; Provisional; Region: PRK01346 471853007710 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853007711 Coenzyme A binding pocket [chemical binding]; other site 471853007712 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007713 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 471853007714 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471853007715 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007716 putative PBP binding loops; other site 471853007717 dimer interface [polypeptide binding]; other site 471853007718 ABC-ATPase subunit interface; other site 471853007719 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007721 dimer interface [polypeptide binding]; other site 471853007722 conserved gate region; other site 471853007723 putative PBP binding loops; other site 471853007724 ABC-ATPase subunit interface; other site 471853007725 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471853007726 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853007727 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 471853007728 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 471853007729 Zn binding site [ion binding]; other site 471853007730 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853007731 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853007732 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 471853007733 HPr interaction site; other site 471853007734 glycerol kinase (GK) interaction site [polypeptide binding]; other site 471853007735 active site 471853007736 phosphorylation site [posttranslational modification] 471853007737 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 471853007738 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 471853007739 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 471853007740 Mechanosensitive ion channel; Region: MS_channel; pfam00924 471853007741 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 471853007742 active site turn [active] 471853007743 phosphorylation site [posttranslational modification] 471853007744 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 471853007745 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 471853007746 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471853007747 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471853007748 Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454 471853007749 apolar tunnel; other site 471853007750 heme binding site [chemical binding]; other site 471853007751 dimerization interface [polypeptide binding]; other site 471853007752 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 471853007753 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 471853007754 active site 471853007755 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 471853007756 catalytic triad [active] 471853007757 dimer interface [polypeptide binding]; other site 471853007758 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 471853007759 active site 471853007760 YfjP GTPase; Region: YfjP; cd11383 471853007761 G1 box; other site 471853007762 GTP/Mg2+ binding site [chemical binding]; other site 471853007763 Switch I region; other site 471853007764 G2 box; other site 471853007765 Switch II region; other site 471853007766 G3 box; other site 471853007767 G4 box; other site 471853007768 G5 box; other site 471853007769 Dynamin family; Region: Dynamin_N; pfam00350 471853007770 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471853007771 G1 box; other site 471853007772 GTP/Mg2+ binding site [chemical binding]; other site 471853007773 G2 box; other site 471853007774 Switch I region; other site 471853007775 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 471853007776 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853007777 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853007778 ABC transporter; Region: ABC_tran_2; pfam12848 471853007779 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853007780 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471853007781 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471853007782 dimer interface [polypeptide binding]; other site 471853007783 ssDNA binding site [nucleotide binding]; other site 471853007784 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471853007785 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471853007786 G1 box; other site 471853007787 GTP/Mg2+ binding site [chemical binding]; other site 471853007788 G2 box; other site 471853007789 Switch I region; other site 471853007790 G3 box; other site 471853007791 Switch II region; other site 471853007792 G4 box; other site 471853007793 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 471853007794 G1 box; other site 471853007795 GTP/Mg2+ binding site [chemical binding]; other site 471853007796 G2 box; other site 471853007797 Switch I region; other site 471853007798 G3 box; other site 471853007799 Switch II region; other site 471853007800 G4 box; other site 471853007801 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853007802 S-adenosylmethionine binding site [chemical binding]; other site 471853007803 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471853007804 Phosphotransferase enzyme family; Region: APH; pfam01636 471853007805 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853007806 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 471853007807 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471853007808 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853007809 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 471853007810 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 471853007811 Fe-S metabolism associated domain; Region: SufE; cl00951 471853007812 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471853007813 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 471853007814 active site residue [active] 471853007815 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471853007816 active site residue [active] 471853007817 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853007818 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853007819 active site 471853007820 catalytic site [active] 471853007821 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 471853007822 catalytic site [active] 471853007823 putative active site [active] 471853007824 putative substrate binding site [chemical binding]; other site 471853007825 dimer interface [polypeptide binding]; other site 471853007826 Predicted lipoprotein of unknown function (DUF2380); Region: DUF2380; cl15289 471853007827 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 471853007828 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853007829 Coenzyme A binding pocket [chemical binding]; other site 471853007830 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853007831 putative DNA binding site [nucleotide binding]; other site 471853007832 putative Zn2+ binding site [ion binding]; other site 471853007833 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471853007834 Low molecular weight phosphatase family; Region: LMWPc; cl00105 471853007835 active site 471853007836 Low molecular weight phosphatase family; Region: LMWPc; cd00115 471853007837 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 471853007838 active site 471853007839 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 471853007840 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 471853007841 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853007842 dimerization interface [polypeptide binding]; other site 471853007843 putative DNA binding site [nucleotide binding]; other site 471853007844 putative Zn2+ binding site [ion binding]; other site 471853007845 Fatty acid desaturase; Region: FA_desaturase; pfam00487 471853007846 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 471853007847 putative di-iron ligands [ion binding]; other site 471853007848 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 471853007849 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 471853007850 Walker A/P-loop; other site 471853007851 ATP binding site [chemical binding]; other site 471853007852 Q-loop/lid; other site 471853007853 ABC transporter signature motif; other site 471853007854 Walker B; other site 471853007855 D-loop; other site 471853007856 H-loop/switch region; other site 471853007857 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 471853007858 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 471853007859 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 471853007860 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 471853007861 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 471853007862 catalytic triad [active] 471853007863 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853007864 putative active site [active] 471853007865 homotrimer interaction site [polypeptide binding]; other site 471853007866 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853007867 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853007868 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853007869 putative active site [active] 471853007870 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 471853007871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007872 dimer interface [polypeptide binding]; other site 471853007873 conserved gate region; other site 471853007874 ABC-ATPase subunit interface; other site 471853007875 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 471853007876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007877 dimer interface [polypeptide binding]; other site 471853007878 conserved gate region; other site 471853007879 ABC-ATPase subunit interface; other site 471853007880 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 471853007881 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 471853007882 Walker A/P-loop; other site 471853007883 ATP binding site [chemical binding]; other site 471853007884 Q-loop/lid; other site 471853007885 ABC transporter signature motif; other site 471853007886 Walker B; other site 471853007887 D-loop; other site 471853007888 H-loop/switch region; other site 471853007889 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 471853007890 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 471853007891 CCC1-related family of proteins; Region: CCC1_like; cl00278 471853007892 Protein of unknown function DUF72; Region: DUF72; pfam01904 471853007893 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471853007894 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007895 NAD(P) binding site [chemical binding]; other site 471853007896 active site 471853007897 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471853007898 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853007899 NAD(P) binding site [chemical binding]; other site 471853007900 endonuclease IV; Provisional; Region: PRK01060 471853007901 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 471853007902 AP (apurinic/apyrimidinic) site pocket; other site 471853007903 DNA interaction; other site 471853007904 Metal-binding active site; metal-binding site 471853007905 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853007906 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 471853007907 catalytic site [active] 471853007908 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853007909 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853007910 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853007911 FAD binding domain; Region: FAD_binding_4; pfam01565 471853007912 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853007913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853007914 active site 471853007915 phosphorylation site [posttranslational modification] 471853007916 intermolecular recognition site; other site 471853007917 dimerization interface [polypeptide binding]; other site 471853007918 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853007919 dimerization interface [polypeptide binding]; other site 471853007920 DNA binding residues [nucleotide binding] 471853007921 Histidine kinase; Region: HisKA_3; pfam07730 471853007922 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853007923 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471853007924 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853007925 Walker A/P-loop; other site 471853007926 ATP binding site [chemical binding]; other site 471853007927 Q-loop/lid; other site 471853007928 ABC transporter signature motif; other site 471853007929 Walker B; other site 471853007930 D-loop; other site 471853007931 H-loop/switch region; other site 471853007932 Part of AAA domain; Region: AAA_19; pfam13245 471853007933 Family description; Region: UvrD_C_2; pfam13538 471853007934 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471853007935 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 471853007936 Methyltransferase domain; Region: Methyltransf_31; pfam13847 471853007937 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853007938 S-adenosylmethionine binding site [chemical binding]; other site 471853007939 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853007940 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853007941 DNA binding residues [nucleotide binding] 471853007942 dimerization interface [polypeptide binding]; other site 471853007943 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853007944 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471853007945 metal binding site [ion binding]; metal-binding site 471853007946 substrate binding pocket [chemical binding]; other site 471853007947 aldose dehydrogenase; Validated; Region: PRK06398 471853007948 classical (c) SDRs; Region: SDR_c; cd05233 471853007949 NAD(P) binding site [chemical binding]; other site 471853007950 active site 471853007951 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007952 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007953 dimer interface [polypeptide binding]; other site 471853007954 conserved gate region; other site 471853007955 putative PBP binding loops; other site 471853007956 ABC-ATPase subunit interface; other site 471853007957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007958 dimer interface [polypeptide binding]; other site 471853007959 conserved gate region; other site 471853007960 putative PBP binding loops; other site 471853007961 ABC-ATPase subunit interface; other site 471853007962 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853007963 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853007964 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853007965 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853007966 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853007967 DNA-binding site [nucleotide binding]; DNA binding site 471853007968 FCD domain; Region: FCD; pfam07729 471853007969 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 471853007970 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853007971 S-adenosylmethionine binding site [chemical binding]; other site 471853007972 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 471853007973 Histidine kinase; Region: HisKA_3; pfam07730 471853007974 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853007975 Mg2+ binding site [ion binding]; other site 471853007976 G-X-G motif; other site 471853007977 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853007978 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853007979 active site 471853007980 phosphorylation site [posttranslational modification] 471853007981 intermolecular recognition site; other site 471853007982 dimerization interface [polypeptide binding]; other site 471853007983 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853007984 DNA binding residues [nucleotide binding] 471853007985 dimerization interface [polypeptide binding]; other site 471853007986 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853007987 putative substrate translocation pore; other site 471853007988 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853007989 amino acid transporter; Region: 2A0306; TIGR00909 471853007990 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 471853007991 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471853007992 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471853007993 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471853007994 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853007995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853007996 dimer interface [polypeptide binding]; other site 471853007997 conserved gate region; other site 471853007998 putative PBP binding loops; other site 471853007999 ABC-ATPase subunit interface; other site 471853008000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008001 dimer interface [polypeptide binding]; other site 471853008002 conserved gate region; other site 471853008003 putative PBP binding loops; other site 471853008004 ABC-ATPase subunit interface; other site 471853008005 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853008006 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853008007 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853008008 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008009 DNA binding site [nucleotide binding] 471853008010 domain linker motif; other site 471853008011 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853008012 Phosphotransferase enzyme family; Region: APH; pfam01636 471853008013 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853008014 active site 471853008015 substrate binding site [chemical binding]; other site 471853008016 ATP binding site [chemical binding]; other site 471853008017 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853008018 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008019 DNA binding site [nucleotide binding] 471853008020 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853008021 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853008022 ligand binding site [chemical binding]; other site 471853008023 dimerization interface [polypeptide binding]; other site 471853008024 ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608 471853008025 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853008026 Walker A/P-loop; other site 471853008027 ATP binding site [chemical binding]; other site 471853008028 Q-loop/lid; other site 471853008029 ABC transporter signature motif; other site 471853008030 Walker B; other site 471853008031 D-loop; other site 471853008032 H-loop/switch region; other site 471853008033 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853008034 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471853008035 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853008036 Walker A/P-loop; other site 471853008037 ATP binding site [chemical binding]; other site 471853008038 Q-loop/lid; other site 471853008039 ABC transporter signature motif; other site 471853008040 Walker B; other site 471853008041 D-loop; other site 471853008042 H-loop/switch region; other site 471853008043 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 471853008044 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853008045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008046 dimer interface [polypeptide binding]; other site 471853008047 conserved gate region; other site 471853008048 putative PBP binding loops; other site 471853008049 ABC-ATPase subunit interface; other site 471853008050 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853008051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008052 dimer interface [polypeptide binding]; other site 471853008053 conserved gate region; other site 471853008054 putative PBP binding loops; other site 471853008055 ABC-ATPase subunit interface; other site 471853008056 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853008057 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853008058 substrate binding site [chemical binding]; other site 471853008059 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 471853008060 nudix motif; other site 471853008061 Protein of unknown function (DUF3054); Region: DUF3054; pfam11255 471853008062 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853008063 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853008064 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853008065 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853008066 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008067 Walker A/P-loop; other site 471853008068 ATP binding site [chemical binding]; other site 471853008069 Q-loop/lid; other site 471853008070 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853008071 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 471853008072 active site 471853008073 dimerization interface [polypeptide binding]; other site 471853008074 ribonuclease PH; Reviewed; Region: rph; PRK00173 471853008075 Ribonuclease PH; Region: RNase_PH_bact; cd11362 471853008076 hexamer interface [polypeptide binding]; other site 471853008077 active site 471853008078 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 471853008079 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 471853008080 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 471853008081 glutamate racemase; Provisional; Region: PRK00865 471853008082 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 471853008083 SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966 471853008084 Domain of unknown function (DUF2017); Region: DUF2017; pfam09438 471853008085 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 471853008086 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 471853008087 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 471853008088 active site 471853008089 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 471853008090 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853008091 ATP binding site [chemical binding]; other site 471853008092 putative Mg++ binding site [ion binding]; other site 471853008093 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 471853008094 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471853008095 Carboxylesterase family; Region: COesterase; pfam00135 471853008096 substrate binding pocket [chemical binding]; other site 471853008097 catalytic triad [active] 471853008098 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853008099 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 471853008100 active site 471853008101 catalytic site [active] 471853008102 metal binding site [ion binding]; metal-binding site 471853008103 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471853008104 active site 471853008105 trimer interface [polypeptide binding]; other site 471853008106 allosteric site; other site 471853008107 active site lid [active] 471853008108 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471853008109 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 471853008110 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853008111 Walker A/P-loop; other site 471853008112 ATP binding site [chemical binding]; other site 471853008113 Q-loop/lid; other site 471853008114 ABC transporter signature motif; other site 471853008115 Walker B; other site 471853008116 D-loop; other site 471853008117 H-loop/switch region; other site 471853008118 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 471853008119 IHF dimer interface [polypeptide binding]; other site 471853008120 IHF - DNA interface [nucleotide binding]; other site 471853008121 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471853008122 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471853008123 Cupin domain; Region: Cupin_2; cl17218 471853008124 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853008125 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 471853008126 ATP binding site [chemical binding]; other site 471853008127 putative Mg++ binding site [ion binding]; other site 471853008128 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853008129 nucleotide binding region [chemical binding]; other site 471853008130 ATP-binding site [chemical binding]; other site 471853008131 SnoaL-like domain; Region: SnoaL_2; pfam12680 471853008132 AAA domain; Region: AAA_33; pfam13671 471853008133 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471853008134 active site 471853008135 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853008136 Coenzyme A binding pocket [chemical binding]; other site 471853008137 putative luciferase-like monooxygenase, FMN-dependent, CE1758 family; Region: LLM_CE1758_fam; TIGR04036 471853008138 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 471853008139 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853008140 Sulfatase; Region: Sulfatase; cl17466 471853008141 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 471853008142 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 471853008143 SmpB-tmRNA interface; other site 471853008144 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 471853008145 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 471853008146 Peptidase family M23; Region: Peptidase_M23; pfam01551 471853008147 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 471853008148 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 471853008149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008150 Walker A/P-loop; other site 471853008151 ATP binding site [chemical binding]; other site 471853008152 Q-loop/lid; other site 471853008153 ABC transporter signature motif; other site 471853008154 Walker B; other site 471853008155 D-loop; other site 471853008156 H-loop/switch region; other site 471853008157 pyruvate phosphate dikinase; Provisional; Region: PRK09279 471853008158 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 471853008159 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 471853008160 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 471853008161 peptide chain release factor 2; Validated; Region: prfB; PRK00578 471853008162 This domain is found in peptide chain release factors; Region: PCRF; smart00937 471853008163 RF-1 domain; Region: RF-1; pfam00472 471853008164 Phosphotransferase enzyme family; Region: APH; pfam01636 471853008165 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853008166 active site 471853008167 ATP binding site [chemical binding]; other site 471853008168 substrate binding site [chemical binding]; other site 471853008169 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 471853008170 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 471853008171 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853008172 catalytic residue [active] 471853008173 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 471853008174 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 471853008175 dimerization interface [polypeptide binding]; other site 471853008176 active site 471853008177 L-aspartate oxidase; Provisional; Region: PRK06175 471853008178 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471853008179 quinolinate synthetase; Provisional; Region: PRK09375 471853008180 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 471853008181 nudix motif; other site 471853008182 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 471853008183 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853008184 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 471853008185 hypothetical protein; Provisional; Region: PRK07236 471853008186 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853008187 putative substrate translocation pore; other site 471853008188 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471853008189 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 471853008190 Filamin/ABP280 repeat; Region: Filamin; pfam00630 471853008191 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 471853008192 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 471853008193 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 471853008194 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 471853008195 NAD binding site [chemical binding]; other site 471853008196 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 471853008197 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 471853008198 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 471853008199 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 471853008200 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471853008201 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 471853008202 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 471853008203 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 471853008204 Walker A motif; other site 471853008205 hexamer interface [polypeptide binding]; other site 471853008206 ATP binding site [chemical binding]; other site 471853008207 Walker B motif; other site 471853008208 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853008209 putative dimer interface [polypeptide binding]; other site 471853008210 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853008211 Helix-turn-helix domain; Region: HTH_18; pfam12833 471853008212 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853008213 DinB superfamily; Region: DinB_2; pfam12867 471853008214 Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138 471853008215 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 471853008216 putative active site [active] 471853008217 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 471853008218 active site 471853008219 bifunctional uroporphyrinogen-III synthetase/response regulator domain protein; Validated; Region: PRK07239 471853008220 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471853008221 active site 471853008222 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 471853008223 DNA binding site [nucleotide binding] 471853008224 Putative NAD(P)-binding; Region: NAD_binding_7; cl17660 471853008225 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 471853008226 homodimer interface [polypeptide binding]; other site 471853008227 active site 471853008228 SAM binding site [chemical binding]; other site 471853008229 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 471853008230 nitrite reductase subunit NirD; Provisional; Region: PRK14989 471853008231 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 471853008232 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 471853008233 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471853008234 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 471853008235 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 471853008236 [4Fe-4S] binding site [ion binding]; other site 471853008237 molybdopterin cofactor binding site; other site 471853008238 This CD includes formate dehydrogenases (Fdh) H and N; nitrate reductases, Nap and Nas; and other related proteins. Formate dehydrogenase H is a component of the anaerobic formate hydrogen lyase complex and catalyzes the reversible oxidation of formate...; Region: MopB_CT_Fdh-Nap-like; cd00508 471853008239 molybdopterin cofactor binding site; other site 471853008240 nitrite extrusion protein (nitrite facilitator); Region: 2A0108; TIGR00886 471853008241 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 471853008242 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 471853008243 [4Fe-4S] binding site [ion binding]; other site 471853008244 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471853008245 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471853008246 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471853008247 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 471853008248 molybdopterin cofactor binding site; other site 471853008249 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 471853008250 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 471853008251 Nitrate reductase gamma subunit; Region: Nitrate_red_gam; pfam02665 471853008252 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853008253 putative substrate translocation pore; other site 471853008254 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 471853008255 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 471853008256 GTP binding site; other site 471853008257 aminotransferase; Validated; Region: PRK07777 471853008258 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853008259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853008260 homodimer interface [polypeptide binding]; other site 471853008261 catalytic residue [active] 471853008262 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 471853008263 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853008264 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853008265 Melibiase; Region: Melibiase; pfam02065 471853008266 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853008267 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008268 dimer interface [polypeptide binding]; other site 471853008269 conserved gate region; other site 471853008270 putative PBP binding loops; other site 471853008271 ABC-ATPase subunit interface; other site 471853008272 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853008273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008274 dimer interface [polypeptide binding]; other site 471853008275 conserved gate region; other site 471853008276 putative PBP binding loops; other site 471853008277 ABC-ATPase subunit interface; other site 471853008278 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853008279 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853008280 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 471853008281 Histidine kinase; Region: HisKA_3; pfam07730 471853008282 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853008283 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853008284 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853008285 active site 471853008286 phosphorylation site [posttranslational modification] 471853008287 intermolecular recognition site; other site 471853008288 dimerization interface [polypeptide binding]; other site 471853008289 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853008290 DNA binding residues [nucleotide binding] 471853008291 dimerization interface [polypeptide binding]; other site 471853008292 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853008293 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471853008294 Walker A/P-loop; other site 471853008295 ATP binding site [chemical binding]; other site 471853008296 Q-loop/lid; other site 471853008297 ABC transporter signature motif; other site 471853008298 Walker B; other site 471853008299 D-loop; other site 471853008300 H-loop/switch region; other site 471853008301 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471853008302 FtsX-like permease family; Region: FtsX; pfam02687 471853008303 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471853008304 Transcription factor WhiB; Region: Whib; pfam02467 471853008305 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 471853008306 PAS fold; Region: PAS_4; pfam08448 471853008307 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 471853008308 Histidine kinase; Region: HisKA_2; pfam07568 471853008309 Protein of unknown function (DUF2505); Region: DUF2505; pfam10698 471853008310 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 471853008311 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 471853008312 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853008313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008314 dimer interface [polypeptide binding]; other site 471853008315 conserved gate region; other site 471853008316 putative PBP binding loops; other site 471853008317 ABC-ATPase subunit interface; other site 471853008318 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853008319 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008320 dimer interface [polypeptide binding]; other site 471853008321 conserved gate region; other site 471853008322 putative PBP binding loops; other site 471853008323 ABC-ATPase subunit interface; other site 471853008324 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853008325 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853008326 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471853008327 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853008328 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853008329 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853008330 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853008331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008332 ABC-ATPase subunit interface; other site 471853008333 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853008334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008335 dimer interface [polypeptide binding]; other site 471853008336 conserved gate region; other site 471853008337 putative PBP binding loops; other site 471853008338 ABC-ATPase subunit interface; other site 471853008339 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 471853008340 beta-galactosidase; Region: BGL; TIGR03356 471853008341 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853008342 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008343 DNA binding site [nucleotide binding] 471853008344 domain linker motif; other site 471853008345 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 471853008346 putative dimerization interface [polypeptide binding]; other site 471853008347 putative ligand binding site [chemical binding]; other site 471853008348 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 471853008349 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 471853008350 active site 471853008351 catalytic site [active] 471853008352 Lamin Tail Domain; Region: LTD; pfam00932 471853008353 metallophosphoesterase, PPA1498 family; Region: P_acnes_RR; cl17623 471853008354 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853008355 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008356 DNA binding site [nucleotide binding] 471853008357 domain linker motif; other site 471853008358 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853008359 dimerization interface [polypeptide binding]; other site 471853008360 ligand binding site [chemical binding]; other site 471853008361 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 471853008362 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008363 Walker A/P-loop; other site 471853008364 ATP binding site [chemical binding]; other site 471853008365 Q-loop/lid; other site 471853008366 ABC transporter signature motif; other site 471853008367 Walker B; other site 471853008368 D-loop; other site 471853008369 H-loop/switch region; other site 471853008370 TOBE domain; Region: TOBE_2; pfam08402 471853008371 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853008372 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853008373 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008374 dimer interface [polypeptide binding]; other site 471853008375 conserved gate region; other site 471853008376 putative PBP binding loops; other site 471853008377 ABC-ATPase subunit interface; other site 471853008378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853008379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008380 dimer interface [polypeptide binding]; other site 471853008381 conserved gate region; other site 471853008382 putative PBP binding loops; other site 471853008383 ABC-ATPase subunit interface; other site 471853008384 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 471853008385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853008386 active site 471853008387 motif I; other site 471853008388 motif II; other site 471853008389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853008390 Proline dehydrogenase; Region: Pro_dh; cl03282 471853008391 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853008392 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 471853008393 NAD(P) binding site [chemical binding]; other site 471853008394 catalytic residues [active] 471853008395 PAS fold; Region: PAS_4; pfam08448 471853008396 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471853008397 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853008398 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 471853008399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853008400 Coenzyme A binding pocket [chemical binding]; other site 471853008401 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 471853008402 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853008403 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471853008404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853008405 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853008406 NAD(P) binding site [chemical binding]; other site 471853008407 active site 471853008408 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 471853008409 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853008410 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853008411 active site 471853008412 catalytic tetrad [active] 471853008413 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853008414 dimerization interface [polypeptide binding]; other site 471853008415 putative DNA binding site [nucleotide binding]; other site 471853008416 putative Zn2+ binding site [ion binding]; other site 471853008417 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 471853008418 putative hydrophobic ligand binding site [chemical binding]; other site 471853008419 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853008420 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853008421 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 471853008422 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853008423 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cd00347 471853008424 Luciferase-like monooxygenase; Region: Bac_luciferase; pfam00296 471853008425 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853008426 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 471853008427 thymidylate synthase; Reviewed; Region: thyA; PRK01827 471853008428 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 471853008429 dimerization interface [polypeptide binding]; other site 471853008430 active site 471853008431 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471853008432 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 471853008433 folate binding site [chemical binding]; other site 471853008434 NADP+ binding site [chemical binding]; other site 471853008435 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 471853008436 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853008437 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008438 DNA binding site [nucleotide binding] 471853008439 domain linker motif; other site 471853008440 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853008441 ligand binding site [chemical binding]; other site 471853008442 dimerization interface [polypeptide binding]; other site 471853008443 MoxR-like ATPases [General function prediction only]; Region: COG0714 471853008444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853008445 Walker A motif; other site 471853008446 ATP binding site [chemical binding]; other site 471853008447 Walker B motif; other site 471853008448 arginine finger; other site 471853008449 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471853008450 Protein of unknown function DUF58; Region: DUF58; pfam01882 471853008451 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 471853008452 Uncharacterized bacterial subgroup of the N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: BaFpgNei_N_1; cd08973 471853008453 putative DNA binding site [nucleotide binding]; other site 471853008454 catalytic residue [active] 471853008455 putative H2TH interface [polypeptide binding]; other site 471853008456 putative catalytic residues [active] 471853008457 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 471853008458 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 471853008459 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853008460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008461 dimer interface [polypeptide binding]; other site 471853008462 conserved gate region; other site 471853008463 putative PBP binding loops; other site 471853008464 ABC-ATPase subunit interface; other site 471853008465 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853008466 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853008467 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008468 putative PBP binding loops; other site 471853008469 dimer interface [polypeptide binding]; other site 471853008470 ABC-ATPase subunit interface; other site 471853008471 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853008472 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853008473 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853008474 DNA binding site [nucleotide binding] 471853008475 domain linker motif; other site 471853008476 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853008477 dimerization interface [polypeptide binding]; other site 471853008478 ligand binding site [chemical binding]; other site 471853008479 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471853008480 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 471853008481 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471853008482 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853008483 FAD binding domain; Region: FAD_binding_4; pfam01565 471853008484 D-arabinono-1,4-lactone oxidase; Region: ALO; pfam04030 471853008485 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 471853008486 A new structural DNA glycosylase; Region: AlkD_like; cd06561 471853008487 active site 471853008488 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853008489 putative DNA binding site [nucleotide binding]; other site 471853008490 putative Zn2+ binding site [ion binding]; other site 471853008491 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471853008492 putative hydrophobic ligand binding site [chemical binding]; other site 471853008493 RibD C-terminal domain; Region: RibD_C; cl17279 471853008494 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 471853008495 Uncharacterized conserved protein [Function unknown]; Region: COG1615; cl09133 471853008496 DinB superfamily; Region: DinB_2; pfam12867 471853008497 HTH domain; Region: HTH_11; pfam08279 471853008498 WYL domain; Region: WYL; pfam13280 471853008499 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 471853008500 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471853008501 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 471853008502 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 471853008503 Protein of unknown function DUF45; Region: DUF45; pfam01863 471853008504 bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882 471853008505 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853008506 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008507 Walker A/P-loop; other site 471853008508 ATP binding site [chemical binding]; other site 471853008509 Q-loop/lid; other site 471853008510 ABC transporter signature motif; other site 471853008511 Walker B; other site 471853008512 D-loop; other site 471853008513 H-loop/switch region; other site 471853008514 PhoD-like phosphatase; Region: PhoD; pfam09423 471853008515 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853008516 putative active site [active] 471853008517 putative metal binding site [ion binding]; other site 471853008518 Part of AAA domain; Region: AAA_19; pfam13245 471853008519 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 471853008520 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471853008521 Family description; Region: UvrD_C_2; pfam13538 471853008522 HRDC domain; Region: HRDC; pfam00570 471853008523 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 471853008524 catalytic residues [active] 471853008525 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 471853008526 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 471853008527 putative NADH binding site [chemical binding]; other site 471853008528 putative active site [active] 471853008529 nudix motif; other site 471853008530 putative metal binding site [ion binding]; other site 471853008531 Phosphotransferase enzyme family; Region: APH; pfam01636 471853008532 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853008533 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 471853008534 Part of AAA domain; Region: AAA_19; pfam13245 471853008535 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 471853008536 Family description; Region: UvrD_C_2; pfam13538 471853008537 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471853008538 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 471853008539 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 471853008540 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 471853008541 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471853008542 dinuclear metal binding motif [ion binding]; other site 471853008543 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 471853008544 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471853008545 ATP binding site [chemical binding]; other site 471853008546 Mg++ binding site [ion binding]; other site 471853008547 motif III; other site 471853008548 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853008549 nucleotide binding region [chemical binding]; other site 471853008550 ATP-binding site [chemical binding]; other site 471853008551 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 471853008552 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 471853008553 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 471853008554 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 471853008555 active site 471853008556 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 471853008557 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 471853008558 proline aminopeptidase P II; Provisional; Region: PRK10879 471853008559 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 471853008560 active site 471853008561 Predicted membrane protein [Function unknown]; Region: COG3463 471853008562 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471853008563 MgtE intracellular N domain; Region: MgtE_N; smart00924 471853008564 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471853008565 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 471853008566 Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716 471853008567 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 471853008568 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 471853008569 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 471853008570 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 471853008571 active site 471853008572 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 471853008573 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 471853008574 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471853008575 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471853008576 RNA polymerase sigma factor SigE; Reviewed; Region: PRK09647 471853008577 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853008578 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853008579 DNA binding residues [nucleotide binding] 471853008580 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 471853008581 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471853008582 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 471853008583 multifunctional aminopeptidase A; Provisional; Region: PRK00913 471853008584 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 471853008585 interface (dimer of trimers) [polypeptide binding]; other site 471853008586 Substrate-binding/catalytic site; other site 471853008587 Zn-binding sites [ion binding]; other site 471853008588 Protein of unknown function (DUF3117); Region: DUF3117; pfam11314 471853008589 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 471853008590 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 471853008591 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 471853008592 metal binding site [ion binding]; metal-binding site 471853008593 putative dimer interface [polypeptide binding]; other site 471853008594 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 471853008595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008596 Walker A/P-loop; other site 471853008597 ATP binding site [chemical binding]; other site 471853008598 Q-loop/lid; other site 471853008599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 471853008600 ABC transporter; Region: ABC_tran_2; pfam12848 471853008601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008602 Walker A/P-loop; other site 471853008603 ATP binding site [chemical binding]; other site 471853008604 Q-loop/lid; other site 471853008605 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008606 Q-loop/lid; other site 471853008607 ABC transporter signature motif; other site 471853008608 ABC transporter signature motif; other site 471853008609 Walker B; other site 471853008610 Walker B; other site 471853008611 D-loop; other site 471853008612 D-loop; other site 471853008613 H-loop/switch region; other site 471853008614 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853008615 flavoprotein disulfide reductase; Reviewed; Region: PRK07845 471853008616 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853008617 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853008618 purine nucleoside phosphorylase; Provisional; Region: PRK08202 471853008619 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 471853008620 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 471853008621 active site 471853008622 substrate binding site [chemical binding]; other site 471853008623 metal binding site [ion binding]; metal-binding site 471853008624 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853008625 putative DNA binding site [nucleotide binding]; other site 471853008626 putative Zn2+ binding site [ion binding]; other site 471853008627 adenosine deaminase; Provisional; Region: PRK09358 471853008628 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 471853008629 active site 471853008630 Domain of unknown function (DUF202); Region: DUF202; cl09954 471853008631 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 471853008632 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 471853008633 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 471853008634 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 471853008635 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471853008636 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 471853008637 active site 471853008638 TDP-binding site; other site 471853008639 acceptor substrate-binding pocket; other site 471853008640 homodimer interface [polypeptide binding]; other site 471853008641 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 471853008642 active site 471853008643 catalytic motif [active] 471853008644 Zn binding site [ion binding]; other site 471853008645 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471853008646 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 471853008647 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471853008648 TM-ABC transporter signature motif; other site 471853008649 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471853008650 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 471853008651 TM-ABC transporter signature motif; other site 471853008652 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 471853008653 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008654 Walker A/P-loop; other site 471853008655 ATP binding site [chemical binding]; other site 471853008656 Q-loop/lid; other site 471853008657 ABC transporter signature motif; other site 471853008658 Walker B; other site 471853008659 D-loop; other site 471853008660 H-loop/switch region; other site 471853008661 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471853008662 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 471853008663 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 471853008664 ligand binding site [chemical binding]; other site 471853008665 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471853008666 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like4; cd08014 471853008667 metal binding site [ion binding]; metal-binding site 471853008668 putative dimer interface [polypeptide binding]; other site 471853008669 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 471853008670 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 471853008671 active site 471853008672 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase C (SdhC)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhC_like; cd03501 471853008673 putative Iron-sulfur protein interface [polypeptide binding]; other site 471853008674 putative proximal heme binding site [chemical binding]; other site 471853008675 putative SdhD-like interface [polypeptide binding]; other site 471853008676 putative distal heme binding site [chemical binding]; other site 471853008677 Succinate:quinone oxidoreductase (SQR) Type A subfamily, Succinate dehydrogenase D (SdhD)-like subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Members of this subfamily reduce low potential...; Region: SQR_TypeA_SdhD_like; cd03500 471853008678 putative Iron-sulfur protein interface [polypeptide binding]; other site 471853008679 putative proximal heme binding site [chemical binding]; other site 471853008680 putative SdhC-like subunit interface [polypeptide binding]; other site 471853008681 putative distal heme binding site [chemical binding]; other site 471853008682 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 471853008683 L-aspartate oxidase; Provisional; Region: PRK06175 471853008684 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471853008685 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 471853008686 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471853008687 catalytic loop [active] 471853008688 iron binding site [ion binding]; other site 471853008689 Phosphotransferase enzyme family; Region: APH; pfam01636 471853008690 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471853008691 active site 471853008692 ATP binding site [chemical binding]; other site 471853008693 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 471853008694 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 471853008695 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 471853008696 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 471853008697 active site 471853008698 HIGH motif; other site 471853008699 dimer interface [polypeptide binding]; other site 471853008700 KMSKS motif; other site 471853008701 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 471853008702 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 471853008703 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 471853008704 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 471853008705 dimer interface [polypeptide binding]; other site 471853008706 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 471853008707 active site 471853008708 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 471853008709 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 471853008710 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 471853008711 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 471853008712 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853008713 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471853008714 Walker A/P-loop; other site 471853008715 ATP binding site [chemical binding]; other site 471853008716 Q-loop/lid; other site 471853008717 ABC transporter signature motif; other site 471853008718 Walker B; other site 471853008719 D-loop; other site 471853008720 H-loop/switch region; other site 471853008721 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 471853008722 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 471853008723 FtsX-like permease family; Region: FtsX; pfam02687 471853008724 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471853008725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853008726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853008727 DNA binding residues [nucleotide binding] 471853008728 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853008729 putative DNA binding site [nucleotide binding]; other site 471853008730 putative Zn2+ binding site [ion binding]; other site 471853008731 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853008732 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853008733 TIGR03086 family protein; Region: TIGR03086 471853008734 uncharacterized Actinobacterial protein TIGR03083; Region: TIGR03083 471853008735 Helix-turn-helix domain; Region: HTH_18; pfam12833 471853008736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853008737 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 471853008738 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 471853008739 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853008740 classical (c) SDRs; Region: SDR_c; cd05233 471853008741 NAD(P) binding site [chemical binding]; other site 471853008742 active site 471853008743 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853008744 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853008745 inhibitor site; inhibition site 471853008746 active site 471853008747 dimer interface [polypeptide binding]; other site 471853008748 catalytic residue [active] 471853008749 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 471853008750 active site 471853008751 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853008752 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853008753 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008754 dimer interface [polypeptide binding]; other site 471853008755 conserved gate region; other site 471853008756 putative PBP binding loops; other site 471853008757 ABC-ATPase subunit interface; other site 471853008758 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853008759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008760 dimer interface [polypeptide binding]; other site 471853008761 conserved gate region; other site 471853008762 putative PBP binding loops; other site 471853008763 ABC-ATPase subunit interface; other site 471853008764 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 471853008765 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853008766 active site 471853008767 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853008768 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853008769 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471853008770 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853008771 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 471853008772 homotrimer interaction site [polypeptide binding]; other site 471853008773 putative active site [active] 471853008774 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 471853008775 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 471853008776 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853008777 catalytic residue [active] 471853008778 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853008779 classical (c) SDRs; Region: SDR_c; cd05233 471853008780 NAD(P) binding site [chemical binding]; other site 471853008781 active site 471853008782 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 471853008783 putative active site [active] 471853008784 putative catalytic site [active] 471853008785 putative DNA binding site [nucleotide binding]; other site 471853008786 putative phosphate binding site [ion binding]; other site 471853008787 metal binding site A [ion binding]; metal-binding site 471853008788 putative AP binding site [nucleotide binding]; other site 471853008789 putative metal binding site B [ion binding]; other site 471853008790 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 471853008791 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 471853008792 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 471853008793 homodimer interface [polypeptide binding]; other site 471853008794 NADP binding site [chemical binding]; other site 471853008795 substrate binding site [chemical binding]; other site 471853008796 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 471853008797 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 471853008798 dimer interface [polypeptide binding]; other site 471853008799 active site 471853008800 glycine-pyridoxal phosphate binding site [chemical binding]; other site 471853008801 folate binding site [chemical binding]; other site 471853008802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 471853008803 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 471853008804 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853008805 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471853008806 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 471853008807 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 471853008808 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 471853008809 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 471853008810 putative substrate binding site [chemical binding]; other site 471853008811 putative active site [active] 471853008812 putative cosubstrate binding site; other site 471853008813 catalytic site [active] 471853008814 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 471853008815 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471853008816 Walker A/P-loop; other site 471853008817 ATP binding site [chemical binding]; other site 471853008818 Q-loop/lid; other site 471853008819 ABC transporter signature motif; other site 471853008820 Walker B; other site 471853008821 D-loop; other site 471853008822 H-loop/switch region; other site 471853008823 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853008824 putative DNA binding site [nucleotide binding]; other site 471853008825 putative Zn2+ binding site [ion binding]; other site 471853008826 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853008827 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471853008828 nucleotide binding site [chemical binding]; other site 471853008829 Ribose/xylose/arabinose/galactoside ABC-type transport systems, permease components [Carbohydrate transport and metabolism]; Region: AraH; COG1172 471853008830 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 471853008831 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 471853008832 TM-ABC transporter signature motif; other site 471853008833 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 471853008834 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 471853008835 Walker A/P-loop; other site 471853008836 ATP binding site [chemical binding]; other site 471853008837 Q-loop/lid; other site 471853008838 ABC transporter signature motif; other site 471853008839 Walker B; other site 471853008840 D-loop; other site 471853008841 H-loop/switch region; other site 471853008842 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 471853008843 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 471853008844 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 471853008845 putative ligand binding site [chemical binding]; other site 471853008846 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 471853008847 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 471853008848 active site 471853008849 catalytic site [active] 471853008850 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 471853008851 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853008852 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853008853 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853008854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008855 dimer interface [polypeptide binding]; other site 471853008856 conserved gate region; other site 471853008857 putative PBP binding loops; other site 471853008858 ABC-ATPase subunit interface; other site 471853008859 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853008860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853008861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853008862 dimer interface [polypeptide binding]; other site 471853008863 conserved gate region; other site 471853008864 putative PBP binding loops; other site 471853008865 ABC-ATPase subunit interface; other site 471853008866 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 471853008867 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 471853008868 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853008869 hypothetical protein; Provisional; Region: PRK07588 471853008870 hypothetical protein; Provisional; Region: PRK07236 471853008871 malate dehydrogenase; Provisional; Region: PRK05442 471853008872 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 471853008873 NAD(P) binding site [chemical binding]; other site 471853008874 dimer interface [polypeptide binding]; other site 471853008875 malate binding site [chemical binding]; other site 471853008876 isocitrate dehydrogenase; Validated; Region: PRK08299 471853008877 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 471853008878 amphipathic channel; other site 471853008879 Asn-Pro-Ala signature motifs; other site 471853008880 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 471853008881 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 471853008882 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 471853008883 purine monophosphate binding site [chemical binding]; other site 471853008884 dimer interface [polypeptide binding]; other site 471853008885 putative catalytic residues [active] 471853008886 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 471853008887 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 471853008888 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 471853008889 active site 471853008890 cosubstrate binding site; other site 471853008891 substrate binding site [chemical binding]; other site 471853008892 catalytic site [active] 471853008893 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 471853008894 CoA binding domain; Region: CoA_binding; smart00881 471853008895 CoA-ligase; Region: Ligase_CoA; pfam00549 471853008896 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 471853008897 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 471853008898 CoA-ligase; Region: Ligase_CoA; pfam00549 471853008899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471853008900 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 471853008901 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 471853008902 active site 471853008903 catalytic triad [active] 471853008904 oxyanion hole [active] 471853008905 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853008906 Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886 471853008907 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853008908 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853008909 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471853008910 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 471853008911 Part of AAA domain; Region: AAA_19; pfam13245 471853008912 Family description; Region: UvrD_C_2; pfam13538 471853008913 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853008914 Histidine kinase; Region: HisKA_3; pfam07730 471853008915 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853008916 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853008917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853008918 active site 471853008919 phosphorylation site [posttranslational modification] 471853008920 intermolecular recognition site; other site 471853008921 dimerization interface [polypeptide binding]; other site 471853008922 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853008923 DNA binding residues [nucleotide binding] 471853008924 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 471853008925 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008926 Walker A/P-loop; other site 471853008927 ATP binding site [chemical binding]; other site 471853008928 Q-loop/lid; other site 471853008929 ABC transporter signature motif; other site 471853008930 Walker B; other site 471853008931 D-loop; other site 471853008932 H-loop/switch region; other site 471853008933 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471853008934 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 471853008935 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 471853008936 Dehydroquinase class II; Region: DHquinase_II; pfam01220 471853008937 trimer interface [polypeptide binding]; other site 471853008938 active site 471853008939 dimer interface [polypeptide binding]; other site 471853008940 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853008941 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853008942 DNA binding residues [nucleotide binding] 471853008943 dimerization interface [polypeptide binding]; other site 471853008944 PspC domain; Region: PspC; cl00864 471853008945 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853008946 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853008947 ATP binding site [chemical binding]; other site 471853008948 Mg2+ binding site [ion binding]; other site 471853008949 G-X-G motif; other site 471853008950 PspC domain; Region: PspC; pfam04024 471853008951 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 471853008952 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 471853008953 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853008954 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853008955 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 471853008956 GMP synthase; Reviewed; Region: guaA; PRK00074 471853008957 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 471853008958 AMP/PPi binding site [chemical binding]; other site 471853008959 candidate oxyanion hole; other site 471853008960 catalytic triad [active] 471853008961 potential glutamine specificity residues [chemical binding]; other site 471853008962 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 471853008963 ATP Binding subdomain [chemical binding]; other site 471853008964 Ligand Binding sites [chemical binding]; other site 471853008965 Dimerization subdomain; other site 471853008966 Domain of unknown function (DUF3817); Region: DUF3817; pfam12823 471853008967 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853008968 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853008969 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008970 Walker A/P-loop; other site 471853008971 ATP binding site [chemical binding]; other site 471853008972 Q-loop/lid; other site 471853008973 ABC transporter signature motif; other site 471853008974 Walker B; other site 471853008975 D-loop; other site 471853008976 H-loop/switch region; other site 471853008977 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853008978 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853008979 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853008980 Walker A/P-loop; other site 471853008981 ATP binding site [chemical binding]; other site 471853008982 Q-loop/lid; other site 471853008983 ABC transporter signature motif; other site 471853008984 Walker B; other site 471853008985 D-loop; other site 471853008986 H-loop/switch region; other site 471853008987 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 471853008988 active site 471853008989 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853008990 putative dimer interface [polypeptide binding]; other site 471853008991 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853008992 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471853008993 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 471853008994 putative phosphoketolase; Provisional; Region: PRK05261 471853008995 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 471853008996 TPP-binding site; other site 471853008997 XFP C-terminal domain; Region: XFP_C; pfam09363 471853008998 phosphate acetyltransferase; Reviewed; Region: PRK05632 471853008999 DRTGG domain; Region: DRTGG; pfam07085 471853009000 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 471853009001 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 471853009002 propionate/acetate kinase; Provisional; Region: PRK12379 471853009003 fumarate hydratase; Reviewed; Region: fumC; PRK00485 471853009004 aspartase (L-aspartate ammonia-lyase) and fumarase class II enzymes; Region: Aspartase_like; cd01596 471853009005 active sites [active] 471853009006 tetramer interface [polypeptide binding]; other site 471853009007 putative acetyltransferase; Provisional; Region: PRK03624 471853009008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853009009 Coenzyme A binding pocket [chemical binding]; other site 471853009010 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 471853009011 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471853009012 active site 471853009013 DNA polymerase III subunit epsilon; Validated; Region: PRK06309 471853009014 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 471853009015 active site 471853009016 catalytic site [active] 471853009017 substrate binding site [chemical binding]; other site 471853009018 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 471853009019 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471853009020 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 471853009021 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 471853009022 active site 471853009023 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853009024 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 471853009025 DNA binding residues [nucleotide binding] 471853009026 Transcription factor WhiB; Region: Whib; pfam02467 471853009027 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 471853009028 oligomerisation interface [polypeptide binding]; other site 471853009029 mobile loop; other site 471853009030 roof hairpin; other site 471853009031 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853009032 S-adenosylmethionine binding site [chemical binding]; other site 471853009033 carboxylate-amine ligase; Provisional; Region: PRK13517 471853009034 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 471853009035 Predicted transcriptional regulator [Transcription]; Region: COG2378 471853009036 HTH domain; Region: HTH_11; pfam08279 471853009037 WYL domain; Region: WYL; pfam13280 471853009038 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 471853009039 active site 471853009040 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853009041 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471853009042 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853009043 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853009044 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471853009045 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 471853009046 UGMP family protein; Validated; Region: PRK09604 471853009047 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 471853009048 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 471853009049 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 471853009050 active site residue [active] 471853009051 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 471853009052 active site residue [active] 471853009053 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 471853009054 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 471853009055 Glycoprotease family; Region: Peptidase_M22; pfam00814 471853009056 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 471853009057 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 471853009058 alanine racemase; Reviewed; Region: alr; PRK00053 471853009059 active site 471853009060 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 471853009061 dimer interface [polypeptide binding]; other site 471853009062 substrate binding site [chemical binding]; other site 471853009063 catalytic residues [active] 471853009064 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 471853009065 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009066 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009067 DNA binding site [nucleotide binding] 471853009068 domain linker motif; other site 471853009069 Ligand binding domain of a transcription regulator of cellulose genes, CelR, which is highly homologous to the LacI-GalR family of bacterial transcription regulators; Region: PBP1_CelR; cd06295 471853009070 putative dimerization interface [polypeptide binding]; other site 471853009071 putative ligand binding site [chemical binding]; other site 471853009072 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853009073 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471853009074 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471853009075 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 471853009076 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 471853009077 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853009078 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009079 dimer interface [polypeptide binding]; other site 471853009080 conserved gate region; other site 471853009081 ABC-ATPase subunit interface; other site 471853009082 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853009083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009084 dimer interface [polypeptide binding]; other site 471853009085 conserved gate region; other site 471853009086 putative PBP binding loops; other site 471853009087 ABC-ATPase subunit interface; other site 471853009088 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 471853009089 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 471853009090 RNHCP domain; Region: RNHCP; pfam12647 471853009091 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853009092 active site 471853009093 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 471853009094 nucleotide binding site/active site [active] 471853009095 HIT family signature motif; other site 471853009096 catalytic residue [active] 471853009097 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 471853009098 Phosphotransferase enzyme family; Region: APH; pfam01636 471853009099 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853009100 substrate binding site [chemical binding]; other site 471853009101 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853009102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853009103 active site 471853009104 phosphorylation site [posttranslational modification] 471853009105 intermolecular recognition site; other site 471853009106 dimerization interface [polypeptide binding]; other site 471853009107 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853009108 DNA binding site [nucleotide binding] 471853009109 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853009110 dimer interface [polypeptide binding]; other site 471853009111 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471853009112 phosphorylation site [posttranslational modification] 471853009113 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853009114 ATP binding site [chemical binding]; other site 471853009115 Mg2+ binding site [ion binding]; other site 471853009116 G-X-G motif; other site 471853009117 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 471853009118 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853009119 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009120 NAD(P) binding site [chemical binding]; other site 471853009121 active site 471853009122 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 471853009123 Ligand binding site; other site 471853009124 Putative Catalytic site; other site 471853009125 DXD motif; other site 471853009126 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 471853009127 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471853009128 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471853009129 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cd00321 471853009130 Moco binding site; other site 471853009131 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 471853009132 metal coordination site [ion binding]; other site 471853009133 probable F420-dependent oxidoreductase, Rv2161c family; Region: F420_Rv2161c; TIGR03619 471853009134 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 471853009135 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 471853009136 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 471853009137 glutaminase active site [active] 471853009138 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471853009139 dimer interface [polypeptide binding]; other site 471853009140 active site 471853009141 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471853009142 dimer interface [polypeptide binding]; other site 471853009143 active site 471853009144 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471853009145 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 471853009146 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 471853009147 binding surface 471853009148 TPR motif; other site 471853009149 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471853009150 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853009151 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471853009152 binding surface 471853009153 TPR motif; other site 471853009154 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853009155 DNA binding site [nucleotide binding] 471853009156 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 471853009157 Bacterial transcriptional activator domain; Region: BTAD; pfam03704 471853009158 Tetratricopeptide repeat; Region: TPR_12; pfam13424 471853009159 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 471853009160 binding surface 471853009161 TPR motif; other site 471853009162 pantothenate kinase; Provisional; Region: PRK05439 471853009163 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 471853009164 ATP-binding site [chemical binding]; other site 471853009165 CoA-binding site [chemical binding]; other site 471853009166 Mg2+-binding site [ion binding]; other site 471853009167 AAA domain; Region: AAA_25; pfam13481 471853009168 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 471853009169 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 471853009170 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 471853009171 active site 471853009172 catalytic residues [active] 471853009173 metal binding site [ion binding]; metal-binding site 471853009174 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 471853009175 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 471853009176 active site 471853009177 substrate binding site [chemical binding]; other site 471853009178 metal binding site [ion binding]; metal-binding site 471853009179 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 471853009180 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 471853009181 23S rRNA interface [nucleotide binding]; other site 471853009182 L3 interface [polypeptide binding]; other site 471853009183 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009184 short chain dehydrogenase; Provisional; Region: PRK06197 471853009185 NAD(P) binding site [chemical binding]; other site 471853009186 active site 471853009187 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 471853009188 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 471853009189 dimerization interface 3.5A [polypeptide binding]; other site 471853009190 active site 471853009191 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853009192 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853009193 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 471853009194 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 471853009195 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 471853009196 alphaNTD - beta interaction site [polypeptide binding]; other site 471853009197 alphaNTD homodimer interface [polypeptide binding]; other site 471853009198 alphaNTD - beta' interaction site [polypeptide binding]; other site 471853009199 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 471853009200 30S ribosomal protein S11; Validated; Region: PRK05309 471853009201 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 471853009202 30S ribosomal protein S13; Region: bact_S13; TIGR03631 471853009203 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 471853009204 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 471853009205 rRNA binding site [nucleotide binding]; other site 471853009206 predicted 30S ribosome binding site; other site 471853009207 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 471853009208 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 471853009209 active site 471853009210 Bacterial sugar transferase; Region: Bac_transf; pfam02397 471853009211 Origin of replication binding protein; Region: Herpes_ori_bp; pfam02399 471853009212 ATP-dependent transcriptional regulator [Transcription]; Region: MalT; COG2909 471853009213 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853009214 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853009215 DNA binding residues [nucleotide binding] 471853009216 dimerization interface [polypeptide binding]; other site 471853009217 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471853009218 active site 471853009219 adenylate kinase; Reviewed; Region: adk; PRK00279 471853009220 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 471853009221 AMP-binding site [chemical binding]; other site 471853009222 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 471853009223 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 471853009224 SecY translocase; Region: SecY; pfam00344 471853009225 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 471853009226 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 471853009227 23S rRNA binding site [nucleotide binding]; other site 471853009228 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 471853009229 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 471853009230 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 471853009231 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 471853009232 23S rRNA interface [nucleotide binding]; other site 471853009233 5S rRNA interface [nucleotide binding]; other site 471853009234 L27 interface [polypeptide binding]; other site 471853009235 L5 interface [polypeptide binding]; other site 471853009236 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 471853009237 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471853009238 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 471853009239 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 471853009240 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 471853009241 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 471853009242 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 471853009243 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 471853009244 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 471853009245 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 471853009246 RNA binding site [nucleotide binding]; other site 471853009247 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 471853009248 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 471853009249 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 471853009250 23S rRNA interface [nucleotide binding]; other site 471853009251 putative translocon interaction site; other site 471853009252 signal recognition particle (SRP54) interaction site; other site 471853009253 L23 interface [polypeptide binding]; other site 471853009254 trigger factor interaction site; other site 471853009255 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 471853009256 23S rRNA interface [nucleotide binding]; other site 471853009257 5S rRNA interface [nucleotide binding]; other site 471853009258 putative antibiotic binding site [chemical binding]; other site 471853009259 L25 interface [polypeptide binding]; other site 471853009260 L27 interface [polypeptide binding]; other site 471853009261 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 471853009262 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 471853009263 G-X-X-G motif; other site 471853009264 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 471853009265 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 471853009266 putative translocon binding site; other site 471853009267 protein-rRNA interface [nucleotide binding]; other site 471853009268 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 471853009269 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 471853009270 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 471853009271 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 471853009272 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 471853009273 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 471853009274 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 471853009275 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 471853009276 elongation factor Tu; Reviewed; Region: PRK00049 471853009277 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 471853009278 G1 box; other site 471853009279 GEF interaction site [polypeptide binding]; other site 471853009280 GTP/Mg2+ binding site [chemical binding]; other site 471853009281 Switch I region; other site 471853009282 G2 box; other site 471853009283 G3 box; other site 471853009284 Switch II region; other site 471853009285 G4 box; other site 471853009286 G5 box; other site 471853009287 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 471853009288 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 471853009289 Antibiotic Binding Site [chemical binding]; other site 471853009290 elongation factor G; Reviewed; Region: PRK00007 471853009291 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 471853009292 G1 box; other site 471853009293 putative GEF interaction site [polypeptide binding]; other site 471853009294 GTP/Mg2+ binding site [chemical binding]; other site 471853009295 Switch I region; other site 471853009296 G2 box; other site 471853009297 G3 box; other site 471853009298 Switch II region; other site 471853009299 G4 box; other site 471853009300 G5 box; other site 471853009301 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471853009302 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471853009303 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471853009304 30S ribosomal protein S7; Validated; Region: PRK05302 471853009305 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 471853009306 S17 interaction site [polypeptide binding]; other site 471853009307 S8 interaction site; other site 471853009308 16S rRNA interaction site [nucleotide binding]; other site 471853009309 streptomycin interaction site [chemical binding]; other site 471853009310 23S rRNA interaction site [nucleotide binding]; other site 471853009311 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 471853009312 MFS/sugar transport protein; Region: MFS_2; pfam13347 471853009313 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853009314 putative substrate translocation pore; other site 471853009315 Thermus thermophiles TTHB029 and similar proteins; Region: YdjC_TTHB029_like; cd10802 471853009316 putative active site [active] 471853009317 YdjC motif; other site 471853009318 Mg binding site [ion binding]; other site 471853009319 homodimer interface [polypeptide binding]; other site 471853009320 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 471853009321 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 471853009322 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853009323 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853009324 Walker A/P-loop; other site 471853009325 ATP binding site [chemical binding]; other site 471853009326 Q-loop/lid; other site 471853009327 ABC transporter signature motif; other site 471853009328 Walker B; other site 471853009329 D-loop; other site 471853009330 H-loop/switch region; other site 471853009331 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 471853009332 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 471853009333 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 471853009334 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 471853009335 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 471853009336 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471853009337 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 471853009338 G-loop; other site 471853009339 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 471853009340 DNA binding site [nucleotide binding] 471853009341 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 471853009342 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 471853009343 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471853009344 RPB12 interaction site [polypeptide binding]; other site 471853009345 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 471853009346 RPB1 interaction site [polypeptide binding]; other site 471853009347 RPB10 interaction site [polypeptide binding]; other site 471853009348 RPB11 interaction site [polypeptide binding]; other site 471853009349 RPB3 interaction site [polypeptide binding]; other site 471853009350 RPB12 interaction site [polypeptide binding]; other site 471853009351 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 471853009352 core dimer interface [polypeptide binding]; other site 471853009353 peripheral dimer interface [polypeptide binding]; other site 471853009354 L10 interface [polypeptide binding]; other site 471853009355 L11 interface [polypeptide binding]; other site 471853009356 putative EF-Tu interaction site [polypeptide binding]; other site 471853009357 putative EF-G interaction site [polypeptide binding]; other site 471853009358 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 471853009359 23S rRNA interface [nucleotide binding]; other site 471853009360 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 471853009361 Domain of unknown function (DUF4383); Region: DUF4383; pfam14325 471853009362 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 471853009363 mRNA/rRNA interface [nucleotide binding]; other site 471853009364 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 471853009365 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 471853009366 23S rRNA interface [nucleotide binding]; other site 471853009367 putative thiostrepton binding site; other site 471853009368 L7/L12 interface [polypeptide binding]; other site 471853009369 L25 interface [polypeptide binding]; other site 471853009370 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 471853009371 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 471853009372 putative homodimer interface [polypeptide binding]; other site 471853009373 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 471853009374 heterodimer interface [polypeptide binding]; other site 471853009375 homodimer interface [polypeptide binding]; other site 471853009376 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 471853009377 aspartate aminotransferase; Provisional; Region: PRK05764 471853009378 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853009379 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853009380 homodimer interface [polypeptide binding]; other site 471853009381 catalytic residue [active] 471853009382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 471853009383 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 471853009384 dimerization interface [polypeptide binding]; other site 471853009385 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853009386 dimer interface [polypeptide binding]; other site 471853009387 phosphorylation site [posttranslational modification] 471853009388 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853009389 ATP binding site [chemical binding]; other site 471853009390 Mg2+ binding site [ion binding]; other site 471853009391 G-X-G motif; other site 471853009392 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853009393 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853009394 active site 471853009395 phosphorylation site [posttranslational modification] 471853009396 intermolecular recognition site; other site 471853009397 dimerization interface [polypeptide binding]; other site 471853009398 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853009399 DNA binding site [nucleotide binding] 471853009400 Phosphotransferase enzyme family; Region: APH; pfam01636 471853009401 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471853009402 substrate binding site [chemical binding]; other site 471853009403 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853009404 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853009405 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853009406 Walker A/P-loop; other site 471853009407 ATP binding site [chemical binding]; other site 471853009408 Q-loop/lid; other site 471853009409 ABC transporter signature motif; other site 471853009410 Walker B; other site 471853009411 D-loop; other site 471853009412 H-loop/switch region; other site 471853009413 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471853009414 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471853009415 adenosine deaminase; Provisional; Region: PRK09358 471853009416 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 471853009417 active site 471853009418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853009419 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471853009420 Walker A/P-loop; other site 471853009421 ATP binding site [chemical binding]; other site 471853009422 Q-loop/lid; other site 471853009423 ABC transporter signature motif; other site 471853009424 Walker B; other site 471853009425 D-loop; other site 471853009426 H-loop/switch region; other site 471853009427 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853009428 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471853009429 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 471853009430 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 471853009431 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 471853009432 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009433 DNA binding site [nucleotide binding] 471853009434 domain linker motif; other site 471853009435 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 471853009436 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471853009437 active site 2 [active] 471853009438 active site 1 [active] 471853009439 (R)-hydratase [(R)-specific enoyl-CoA hydratase]. Catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. The structure of the monomer includes a five-strand antiparallel...; Region: R_hydratase_like; cd03441 471853009440 active site 471853009441 catalytic site [active] 471853009442 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 471853009443 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 471853009444 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853009445 catalytic Zn binding site [ion binding]; other site 471853009446 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 471853009447 structural Zn binding site [ion binding]; other site 471853009448 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 471853009449 phosphonatase-like hydrolase; Region: PhnX-like; TIGR03351 471853009450 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 471853009451 motif II; other site 471853009452 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 471853009453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 471853009454 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 471853009455 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853009456 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471853009457 heat shock protein HtpX; Provisional; Region: PRK03072 471853009458 ferredoxin-NADP+ reductase; Region: PLN02852 471853009459 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471853009460 Predicted permeases [General function prediction only]; Region: RarD; COG2962 471853009461 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853009462 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 471853009463 active site 471853009464 catalytic residues [active] 471853009465 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853009466 catalytic residues [active] 471853009467 Protein of unknown function (DUF690); Region: DUF690; cl04939 471853009468 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 471853009469 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 471853009470 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 471853009471 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 471853009472 active site 471853009473 catalytic residues [active] 471853009474 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 471853009475 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 471853009476 RDD family; Region: RDD; pfam06271 471853009477 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 471853009478 phosphopeptide binding site; other site 471853009479 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 471853009480 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471853009481 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 471853009482 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471853009483 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 471853009484 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 471853009485 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 471853009486 substrate binding pocket [chemical binding]; other site 471853009487 chain length determination region; other site 471853009488 substrate-Mg2+ binding site; other site 471853009489 catalytic residues [active] 471853009490 aspartate-rich region 1; other site 471853009491 active site lid residues [active] 471853009492 aspartate-rich region 2; other site 471853009493 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 471853009494 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471853009495 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 471853009496 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471853009497 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 471853009498 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 471853009499 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471853009500 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 471853009501 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 471853009502 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 471853009503 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 471853009504 4Fe-4S binding domain; Region: Fer4; pfam00037 471853009505 4Fe-4S binding domain; Region: Fer4; pfam00037 471853009506 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 471853009507 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 471853009508 NADH dehydrogenase subunit G; Validated; Region: PRK07860 471853009509 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471853009510 catalytic loop [active] 471853009511 iron binding site [ion binding]; other site 471853009512 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 471853009513 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 471853009514 molybdopterin cofactor binding site; other site 471853009515 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 471853009516 NADH-quinone oxidoreductase, F subunit; Region: nuoF_fam; TIGR01959 471853009517 SLBB domain; Region: SLBB; pfam10531 471853009518 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 471853009519 NADH dehydrogenase subunit E; Validated; Region: PRK07539 471853009520 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 471853009521 putative dimer interface [polypeptide binding]; other site 471853009522 [2Fe-2S] cluster binding site [ion binding]; other site 471853009523 NADH dehydrogenase I, D subunit; Region: NuoD; TIGR01962 471853009524 NADH dehydrogenase subunit D; Validated; Region: PRK06075 471853009525 NADH dehydrogenase subunit C; Provisional; Region: PRK07785 471853009526 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 471853009527 NADH dehydrogenase subunit B; Validated; Region: PRK06411 471853009528 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 471853009529 geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032 471853009530 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471853009531 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 471853009532 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853009533 S-adenosylmethionine binding site [chemical binding]; other site 471853009534 Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169 471853009535 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 471853009536 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471853009537 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471853009538 protein binding site [polypeptide binding]; other site 471853009539 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 471853009540 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 471853009541 dimer interface [polypeptide binding]; other site 471853009542 tetramer interface [polypeptide binding]; other site 471853009543 PYR/PP interface [polypeptide binding]; other site 471853009544 TPP binding site [chemical binding]; other site 471853009545 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 471853009546 TPP-binding site; other site 471853009547 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 471853009548 o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927 471853009549 active site 471853009550 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 471853009551 Domain of unknown function DUF21; Region: DUF21; pfam01595 471853009552 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 471853009553 Transporter associated domain; Region: CorC_HlyC; smart01091 471853009554 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 471853009555 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 471853009556 tetramer interface [polypeptide binding]; other site 471853009557 heme binding pocket [chemical binding]; other site 471853009558 NADPH binding site [chemical binding]; other site 471853009559 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 471853009560 metal binding site 2 [ion binding]; metal-binding site 471853009561 putative DNA binding helix; other site 471853009562 metal binding site 1 [ion binding]; metal-binding site 471853009563 dimer interface [polypeptide binding]; other site 471853009564 structural Zn2+ binding site [ion binding]; other site 471853009565 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 471853009566 MgtE intracellular N domain; Region: MgtE_N; smart00924 471853009567 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 471853009568 Divalent cation transporter; Region: MgtE; cl00786 471853009569 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 471853009570 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 471853009571 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 471853009572 substrate binding site [chemical binding]; other site 471853009573 oxyanion hole (OAH) forming residues; other site 471853009574 trimer interface [polypeptide binding]; other site 471853009575 Protein of unknown function (DUF3048); Region: DUF3048; pfam11258 471853009576 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 471853009577 active site 471853009578 AMP binding site [chemical binding]; other site 471853009579 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 471853009580 UbiA prenyltransferase family; Region: UbiA; pfam01040 471853009581 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 471853009582 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471853009583 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 471853009584 ResB-like family; Region: ResB; pfam05140 471853009585 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 471853009586 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 471853009587 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 471853009588 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 471853009589 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471853009590 catalytic residues [active] 471853009591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853009592 catalytic core [active] 471853009593 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853009594 MarR family; Region: MarR; pfam01047 471853009595 Uncharacterized conserved protein [Function unknown]; Region: COG2353 471853009596 Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768 471853009597 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 471853009598 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853009599 motif II; other site 471853009600 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471853009601 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853009602 non-specific DNA binding site [nucleotide binding]; other site 471853009603 salt bridge; other site 471853009604 sequence-specific DNA binding site [nucleotide binding]; other site 471853009605 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 471853009606 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 471853009607 putative active site [active] 471853009608 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 471853009609 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 471853009610 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 471853009611 DNA binding domain, excisionase family; Region: excise; TIGR01764 471853009612 Domain of unknown function DUF77; Region: DUF77; pfam01910 471853009613 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 471853009614 glycosyltransferase, MGT family; Region: MGT; TIGR01426 471853009615 active site 471853009616 TDP-binding site; other site 471853009617 acceptor substrate-binding pocket; other site 471853009618 RNA polymerase factor sigma-70; Validated; Region: PRK08241 471853009619 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853009620 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853009621 DNA binding residues [nucleotide binding] 471853009622 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853009623 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 471853009624 catalytic site [active] 471853009625 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 471853009626 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 471853009627 active site 471853009628 Zn binding site [ion binding]; other site 471853009629 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 471853009630 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 471853009631 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 471853009632 TrkA-N domain; Region: TrkA_N; pfam02254 471853009633 TrkA-C domain; Region: TrkA_C; pfam02080 471853009634 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853009635 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 471853009636 NAD(P) binding site [chemical binding]; other site 471853009637 L-arabinose isomerase; Provisional; Region: PRK02929 471853009638 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 471853009639 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 471853009640 trimer interface [polypeptide binding]; other site 471853009641 putative substrate binding site [chemical binding]; other site 471853009642 putative metal binding site [ion binding]; other site 471853009643 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 471853009644 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 471853009645 intersubunit interface [polypeptide binding]; other site 471853009646 active site 471853009647 Zn2+ binding site [ion binding]; other site 471853009648 ribulokinase; Provisional; Region: PRK04123 471853009649 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853009650 nucleotide binding site [chemical binding]; other site 471853009651 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009652 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009653 DNA binding site [nucleotide binding] 471853009654 domain linker motif; other site 471853009655 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 471853009656 ligand binding site [chemical binding]; other site 471853009657 dimerization interface (open form) [polypeptide binding]; other site 471853009658 dimerization interface (closed form) [polypeptide binding]; other site 471853009659 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 471853009660 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 471853009661 DNA repair protein RadA; Provisional; Region: PRK11823 471853009662 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 471853009663 Walker A motif; other site 471853009664 ATP binding site [chemical binding]; other site 471853009665 Walker B motif; other site 471853009666 DNA integrity scanning protein DisA; Provisional; Region: PRK13482 471853009667 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 471853009668 DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635 471853009669 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471853009670 endonuclease III; Region: ENDO3c; smart00478 471853009671 minor groove reading motif; other site 471853009672 helix-hairpin-helix signature motif; other site 471853009673 substrate binding pocket [chemical binding]; other site 471853009674 active site 471853009675 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 471853009676 Alpha/beta hydrolase; Region: Abhydrolase_8; pfam06259 471853009677 N-acetylglutamate synthase; Validated; Region: PRK07922 471853009678 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 471853009679 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853009680 DNA binding residues [nucleotide binding] 471853009681 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 471853009682 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 471853009683 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 471853009684 amphipathic channel; other site 471853009685 Asn-Pro-Ala signature motifs; other site 471853009686 glycerol kinase; Provisional; Region: glpK; PRK00047 471853009687 Cellulomonas sp. glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_CsGK_like; cd07789 471853009688 N- and C-terminal domain interface [polypeptide binding]; other site 471853009689 active site 471853009690 MgATP binding site [chemical binding]; other site 471853009691 catalytic site [active] 471853009692 metal binding site [ion binding]; metal-binding site 471853009693 putative homotetramer interface [polypeptide binding]; other site 471853009694 glycerol binding site [chemical binding]; other site 471853009695 homodimer interface [polypeptide binding]; other site 471853009696 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 471853009697 substrate binding site [chemical binding]; other site 471853009698 active site 471853009699 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 471853009700 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 471853009701 phosphate binding site [ion binding]; other site 471853009702 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471853009703 active site 471853009704 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853009705 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471853009706 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471853009707 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 471853009708 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853009709 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471853009710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853009711 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853009712 amino acid transporter; Region: 2A0306; TIGR00909 471853009713 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853009714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009715 dimer interface [polypeptide binding]; other site 471853009716 conserved gate region; other site 471853009717 putative PBP binding loops; other site 471853009718 ABC-ATPase subunit interface; other site 471853009719 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009720 dimer interface [polypeptide binding]; other site 471853009721 conserved gate region; other site 471853009722 putative PBP binding loops; other site 471853009723 ABC-ATPase subunit interface; other site 471853009724 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853009725 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853009726 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 471853009727 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853009728 D-xylulose kinase; Region: XylB; TIGR01312 471853009729 nucleotide binding site [chemical binding]; other site 471853009730 xylose isomerase; Provisional; Region: PRK12677 471853009731 xylose isomerase, Arthrobacter type; Region: xylA_Arthro; TIGR02631 471853009732 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 471853009733 non-specific DNA interactions [nucleotide binding]; other site 471853009734 DNA binding site [nucleotide binding] 471853009735 sequence specific DNA binding site [nucleotide binding]; other site 471853009736 putative cAMP binding site [chemical binding]; other site 471853009737 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853009738 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853009739 1,6-dihydroxycyclohexa-2,4-diene-1-carboxylate dehydrogenase; Provisional; Region: benD; PRK12823 471853009740 classical (c) SDRs; Region: SDR_c; cd05233 471853009741 NAD(P) binding site [chemical binding]; other site 471853009742 active site 471853009743 Bacterial PH domain; Region: DUF304; pfam03703 471853009744 Bacterial PH domain; Region: DUF304; pfam03703 471853009745 Bacterial PH domain; Region: DUF304; cl01348 471853009746 glucuronate isomerase; Reviewed; Region: PRK02925 471853009747 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 471853009748 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009749 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009750 DNA binding site [nucleotide binding] 471853009751 domain linker motif; other site 471853009752 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009753 dimerization interface [polypeptide binding]; other site 471853009754 ligand binding site [chemical binding]; other site 471853009755 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853009756 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009757 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853009758 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853009759 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471853009760 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 471853009761 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 471853009762 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 471853009763 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 471853009764 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471853009765 metal binding site [ion binding]; metal-binding site 471853009766 substrate binding pocket [chemical binding]; other site 471853009767 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009768 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009769 DNA binding site [nucleotide binding] 471853009770 domain linker motif; other site 471853009771 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 471853009772 putative dimerization interface [polypeptide binding]; other site 471853009773 putative ligand binding site [chemical binding]; other site 471853009774 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 471853009775 Protein of unknown function, DUF624; Region: DUF624; cl02369 471853009776 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853009777 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 471853009778 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 471853009779 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 471853009780 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853009781 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853009782 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853009783 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009784 dimer interface [polypeptide binding]; other site 471853009785 conserved gate region; other site 471853009786 ABC-ATPase subunit interface; other site 471853009787 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853009788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009789 dimer interface [polypeptide binding]; other site 471853009790 conserved gate region; other site 471853009791 putative PBP binding loops; other site 471853009792 ABC-ATPase subunit interface; other site 471853009793 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 471853009794 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471853009795 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471853009796 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853009797 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853009798 Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631 471853009799 SnoaL-like domain; Region: SnoaL_2; pfam12680 471853009800 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853009801 FAD binding pocket [chemical binding]; other site 471853009802 FAD binding motif [chemical binding]; other site 471853009803 phosphate binding motif [ion binding]; other site 471853009804 NAD binding pocket [chemical binding]; other site 471853009805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853009806 putative substrate translocation pore; other site 471853009807 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853009808 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853009809 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 471853009810 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009811 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 471853009812 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 471853009813 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853009814 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 471853009815 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853009816 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009817 dimer interface [polypeptide binding]; other site 471853009818 conserved gate region; other site 471853009819 putative PBP binding loops; other site 471853009820 ABC-ATPase subunit interface; other site 471853009821 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471853009822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009823 dimer interface [polypeptide binding]; other site 471853009824 conserved gate region; other site 471853009825 putative PBP binding loops; other site 471853009826 ABC-ATPase subunit interface; other site 471853009827 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853009828 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853009829 Walker A/P-loop; other site 471853009830 ATP binding site [chemical binding]; other site 471853009831 Q-loop/lid; other site 471853009832 ABC transporter signature motif; other site 471853009833 Walker B; other site 471853009834 D-loop; other site 471853009835 H-loop/switch region; other site 471853009836 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853009837 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853009838 Walker A/P-loop; other site 471853009839 ATP binding site [chemical binding]; other site 471853009840 Q-loop/lid; other site 471853009841 ABC transporter signature motif; other site 471853009842 Walker B; other site 471853009843 D-loop; other site 471853009844 H-loop/switch region; other site 471853009845 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853009846 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 471853009847 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853009848 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853009849 active site 471853009850 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 471853009851 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471853009852 inhibitor-cofactor binding pocket; inhibition site 471853009853 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853009854 catalytic residue [active] 471853009855 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 471853009856 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 471853009857 inhibitor-cofactor binding pocket; inhibition site 471853009858 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853009859 catalytic residue [active] 471853009860 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009861 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853009862 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853009863 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009864 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853009865 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853009866 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853009867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853009868 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853009869 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853009870 inhibitor site; inhibition site 471853009871 active site 471853009872 dimer interface [polypeptide binding]; other site 471853009873 catalytic residue [active] 471853009874 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853009875 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 471853009876 active site 471853009877 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 471853009878 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 471853009879 active site 471853009880 trimer interface [polypeptide binding]; other site 471853009881 allosteric site; other site 471853009882 active site lid [active] 471853009883 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 471853009884 dimerization interface [polypeptide binding]; other site 471853009885 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 471853009886 putative active cleft [active] 471853009887 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477 471853009888 putative transporter; Provisional; Region: PRK10484 471853009889 Na binding site [ion binding]; other site 471853009890 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009891 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009892 DNA binding site [nucleotide binding] 471853009893 domain linker motif; other site 471853009894 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009895 dimerization interface [polypeptide binding]; other site 471853009896 ligand binding site [chemical binding]; other site 471853009897 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 471853009898 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009899 DNA binding site [nucleotide binding] 471853009900 domain linker motif; other site 471853009901 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009902 ligand binding site [chemical binding]; other site 471853009903 dimerization interface [polypeptide binding]; other site 471853009904 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 471853009905 Pectate lyase; Region: Pec_lyase_C; cl01593 471853009906 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471853009907 G1 box; other site 471853009908 GTP/Mg2+ binding site [chemical binding]; other site 471853009909 G2 box; other site 471853009910 Switch I region; other site 471853009911 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009912 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853009913 Methane oxygenase PmoA; Region: PmoA; pfam14100 471853009914 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009915 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853009916 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853009917 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009918 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853009919 Protein of unknown function (DUF993); Region: DUF993; pfam06187 471853009920 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 471853009921 AAA ATPase domain; Region: AAA_16; pfam13191 471853009922 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853009923 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853009924 DNA binding residues [nucleotide binding] 471853009925 dimerization interface [polypeptide binding]; other site 471853009926 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471853009927 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 471853009928 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 471853009929 Amidohydrolase; Region: Amidohydro_2; pfam04909 471853009930 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 471853009931 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 471853009932 Na binding site [ion binding]; other site 471853009933 Protein of unknown function, DUF485; Region: DUF485; pfam04341 471853009934 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471853009935 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 471853009936 Na binding site [ion binding]; other site 471853009937 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 471853009938 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853009939 active site 471853009940 phosphorylation site [posttranslational modification] 471853009941 intermolecular recognition site; other site 471853009942 dimerization interface [polypeptide binding]; other site 471853009943 LytTr DNA-binding domain; Region: LytTR; smart00850 471853009944 Histidine kinase; Region: His_kinase; pfam06580 471853009945 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853009946 ATP binding site [chemical binding]; other site 471853009947 Mg2+ binding site [ion binding]; other site 471853009948 G-X-G motif; other site 471853009949 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 471853009950 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 471853009951 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 471853009952 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 471853009953 Protein of unknown function (DUF419); Region: DUF419; cl15265 471853009954 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 471853009955 putative active site [active] 471853009956 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853009957 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853009958 DNA binding site [nucleotide binding] 471853009959 domain linker motif; other site 471853009960 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853009961 dimerization interface [polypeptide binding]; other site 471853009962 ligand binding site [chemical binding]; other site 471853009963 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 471853009964 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853009965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009966 dimer interface [polypeptide binding]; other site 471853009967 conserved gate region; other site 471853009968 ABC-ATPase subunit interface; other site 471853009969 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853009970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853009971 dimer interface [polypeptide binding]; other site 471853009972 conserved gate region; other site 471853009973 putative PBP binding loops; other site 471853009974 ABC-ATPase subunit interface; other site 471853009975 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853009976 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 471853009977 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 471853009978 aromatic chitin/cellulose binding site residues [chemical binding]; other site 471853009979 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 471853009980 aromatic chitin/cellulose binding site residues [chemical binding]; other site 471853009981 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 471853009982 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 471853009983 sugar binding site [chemical binding]; other site 471853009984 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 471853009985 galactonate dehydratase; Provisional; Region: PRK14017 471853009986 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853009987 active site pocket [active] 471853009988 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 471853009989 active site 471853009990 catalytic triad [active] 471853009991 oxyanion hole [active] 471853009992 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 471853009993 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853009994 active site 471853009995 metal binding site [ion binding]; metal-binding site 471853009996 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853009997 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853009998 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853009999 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 471853010000 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 471853010001 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853010002 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853010003 DNA binding site [nucleotide binding] 471853010004 domain linker motif; other site 471853010005 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853010006 ligand binding site [chemical binding]; other site 471853010007 dimerization interface [polypeptide binding]; other site 471853010008 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853010009 The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509 471853010010 substrate binding site [chemical binding]; other site 471853010011 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853010012 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010013 dimer interface [polypeptide binding]; other site 471853010014 conserved gate region; other site 471853010015 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853010016 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 471853010017 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010018 dimer interface [polypeptide binding]; other site 471853010019 conserved gate region; other site 471853010020 putative PBP binding loops; other site 471853010021 ABC-ATPase subunit interface; other site 471853010022 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853010023 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853010024 Walker A/P-loop; other site 471853010025 ATP binding site [chemical binding]; other site 471853010026 Q-loop/lid; other site 471853010027 ABC transporter signature motif; other site 471853010028 Walker B; other site 471853010029 D-loop; other site 471853010030 H-loop/switch region; other site 471853010031 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853010032 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853010033 Walker A/P-loop; other site 471853010034 ATP binding site [chemical binding]; other site 471853010035 Q-loop/lid; other site 471853010036 ABC transporter signature motif; other site 471853010037 Walker B; other site 471853010038 D-loop; other site 471853010039 H-loop/switch region; other site 471853010040 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853010041 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 471853010042 Clp amino terminal domain; Region: Clp_N; pfam02861 471853010043 Clp amino terminal domain; Region: Clp_N; pfam02861 471853010044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853010045 Walker A motif; other site 471853010046 ATP binding site [chemical binding]; other site 471853010047 Walker B motif; other site 471853010048 arginine finger; other site 471853010049 UvrB/uvrC motif; Region: UVR; pfam02151 471853010050 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853010051 Walker A motif; other site 471853010052 ATP binding site [chemical binding]; other site 471853010053 Walker B motif; other site 471853010054 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471853010055 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 471853010056 ADP-ribose binding site [chemical binding]; other site 471853010057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010058 putative substrate translocation pore; other site 471853010059 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853010060 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853010061 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010062 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 471853010063 putative active site [active] 471853010064 dimerization interface [polypeptide binding]; other site 471853010065 putative tRNAtyr binding site [nucleotide binding]; other site 471853010066 L-asparaginase II; Region: Asparaginase_II; pfam06089 471853010067 Protein of unknown function (DUF2516); Region: DUF2516; pfam10724 471853010068 PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874 471853010069 putative active site [active] 471853010070 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 471853010071 Predicted membrane protein [Function unknown]; Region: COG4129 471853010072 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 471853010073 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 471853010074 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 471853010075 nitrobindin heme-binding domain; Region: nitrobindin; cd07828 471853010076 heme-binding site [chemical binding]; other site 471853010077 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853010078 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853010079 DNA binding site [nucleotide binding] 471853010080 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 471853010081 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 471853010082 Septum formation; Region: Septum_form; pfam13845 471853010083 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 471853010084 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 471853010085 Walker A/P-loop; other site 471853010086 ATP binding site [chemical binding]; other site 471853010087 Q-loop/lid; other site 471853010088 ABC transporter signature motif; other site 471853010089 Walker B; other site 471853010090 D-loop; other site 471853010091 H-loop/switch region; other site 471853010092 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 471853010093 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010094 dimer interface [polypeptide binding]; other site 471853010095 conserved gate region; other site 471853010096 putative PBP binding loops; other site 471853010097 ABC-ATPase subunit interface; other site 471853010098 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 471853010099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010100 dimer interface [polypeptide binding]; other site 471853010101 conserved gate region; other site 471853010102 putative PBP binding loops; other site 471853010103 ABC-ATPase subunit interface; other site 471853010104 PBP superfamily domain; Region: PBP_like_2; cl17296 471853010105 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471853010106 active site 471853010107 Ap6A binding site [chemical binding]; other site 471853010108 nudix motif; other site 471853010109 metal binding site [ion binding]; metal-binding site 471853010110 polyphosphate kinase; Provisional; Region: PRK05443 471853010111 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 471853010112 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 471853010113 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 471853010114 putative domain interface [polypeptide binding]; other site 471853010115 putative active site [active] 471853010116 catalytic site [active] 471853010117 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 471853010118 putative domain interface [polypeptide binding]; other site 471853010119 putative active site [active] 471853010120 catalytic site [active] 471853010121 mycothiol synthase; Region: mycothiol_MshD; TIGR03448 471853010122 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853010123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853010124 Coenzyme A binding pocket [chemical binding]; other site 471853010125 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471853010126 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853010127 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853010128 DNA binding residues [nucleotide binding] 471853010129 Anti-sigma-K factor rskA; Region: RskA; pfam10099 471853010130 Iron-sulphur cluster biosynthesis; Region: Fe-S_biosyn; cl00400 471853010131 META domain; Region: META; pfam03724 471853010132 CoA binding domain; Region: CoA_binding_2; pfam13380 471853010133 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 471853010134 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 471853010135 homodimer interface [polypeptide binding]; other site 471853010136 substrate-cofactor binding pocket; other site 471853010137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853010138 catalytic residue [active] 471853010139 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471853010140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010141 dimer interface [polypeptide binding]; other site 471853010142 conserved gate region; other site 471853010143 putative PBP binding loops; other site 471853010144 ABC-ATPase subunit interface; other site 471853010145 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 471853010146 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 471853010147 substrate binding pocket [chemical binding]; other site 471853010148 membrane-bound complex binding site; other site 471853010149 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471853010150 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853010151 Walker A/P-loop; other site 471853010152 ATP binding site [chemical binding]; other site 471853010153 Q-loop/lid; other site 471853010154 ABC transporter signature motif; other site 471853010155 Walker B; other site 471853010156 D-loop; other site 471853010157 H-loop/switch region; other site 471853010158 Protein of unknown function (DUF3060); Region: DUF3060; pfam11259 471853010159 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853010160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010161 putative substrate translocation pore; other site 471853010162 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471853010163 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471853010164 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471853010165 Right handed beta helix region; Region: Beta_helix; pfam13229 471853010166 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853010167 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853010168 inhibitor site; inhibition site 471853010169 active site 471853010170 dimer interface [polypeptide binding]; other site 471853010171 catalytic residue [active] 471853010172 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853010173 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 471853010174 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853010175 Walker A/P-loop; other site 471853010176 ATP binding site [chemical binding]; other site 471853010177 Q-loop/lid; other site 471853010178 ABC transporter signature motif; other site 471853010179 Walker B; other site 471853010180 D-loop; other site 471853010181 H-loop/switch region; other site 471853010182 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853010183 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 471853010184 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853010185 Walker A/P-loop; other site 471853010186 ATP binding site [chemical binding]; other site 471853010187 Q-loop/lid; other site 471853010188 ABC transporter signature motif; other site 471853010189 Walker B; other site 471853010190 D-loop; other site 471853010191 H-loop/switch region; other site 471853010192 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853010193 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 471853010194 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471853010195 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 471853010196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010197 dimer interface [polypeptide binding]; other site 471853010198 conserved gate region; other site 471853010199 putative PBP binding loops; other site 471853010200 ABC-ATPase subunit interface; other site 471853010201 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853010202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010203 dimer interface [polypeptide binding]; other site 471853010204 conserved gate region; other site 471853010205 ABC-ATPase subunit interface; other site 471853010206 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853010207 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853010208 DNA binding site [nucleotide binding] 471853010209 domain linker motif; other site 471853010210 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853010211 ligand binding site [chemical binding]; other site 471853010212 dimerization interface [polypeptide binding]; other site 471853010213 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853010214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 471853010215 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 471853010216 CAAX protease self-immunity; Region: Abi; pfam02517 471853010217 EthD domain; Region: EthD; cl17553 471853010218 Asp23 family; Region: Asp23; pfam03780 471853010219 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853010220 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853010221 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853010222 DNA binding residues [nucleotide binding] 471853010223 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853010224 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853010225 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853010226 DNA binding residues [nucleotide binding] 471853010227 Sortase E (SrtE) is a membrane transpeptidase found in gram-positive bacteria that cleaves surface proteins at a cell sorting motif and catalyzes a transpeptidation reaction in which the surface protein substrate is covalently linked to peptidoglycan for...; Region: Sortase_E; cd05829 471853010228 active site 471853010229 putative catalytic site [active] 471853010230 Domain of unknown function (DUF4397); Region: DUF4397; pfam14344 471853010231 Fasciclin domain; Region: Fasciclin; cl02663 471853010232 Predicted acetyltransferase [General function prediction only]; Region: COG2388 471853010233 Pirin-related protein [General function prediction only]; Region: COG1741 471853010234 Pirin; Region: Pirin; pfam02678 471853010235 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 471853010236 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 471853010237 Membrane transport protein; Region: Mem_trans; cl09117 471853010238 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853010239 methionine sulfoxide reductase B; Provisional; Region: PRK00222 471853010240 SelR domain; Region: SelR; pfam01641 471853010241 Uncharacterized conserved protein [Function unknown]; Region: COG2966 471853010242 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 471853010243 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 471853010244 glycerate dehydrogenase; Provisional; Region: PRK06932 471853010245 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_3; cd12160 471853010246 putative ligand binding site [chemical binding]; other site 471853010247 putative NAD binding site [chemical binding]; other site 471853010248 catalytic site [active] 471853010249 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471853010250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 471853010251 DEAD-like helicases superfamily; Region: DEXDc; smart00487 471853010252 ATP binding site [chemical binding]; other site 471853010253 putative Mg++ binding site [ion binding]; other site 471853010254 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 471853010255 nucleotide binding region [chemical binding]; other site 471853010256 ATP-binding site [chemical binding]; other site 471853010257 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471853010258 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 471853010259 putative NAD(P) binding site [chemical binding]; other site 471853010260 putative active site [active] 471853010261 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 471853010262 prenyltransferase; Reviewed; Region: ubiA; PRK13105 471853010263 lycopene cyclase domain; Region: CarR_dom_SF; TIGR03462 471853010264 phytoene desaturase; Region: crtI_fam; TIGR02734 471853010265 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 471853010266 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 471853010267 substrate binding pocket [chemical binding]; other site 471853010268 substrate-Mg2+ binding site; other site 471853010269 aspartate-rich region 1; other site 471853010270 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 471853010271 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 471853010272 substrate binding site [chemical binding]; other site 471853010273 ATP binding site [chemical binding]; other site 471853010274 Survival protein SurE; Region: SurE; cl00448 471853010275 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 471853010276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010277 NAD(P) binding site [chemical binding]; other site 471853010278 active site 471853010279 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 471853010280 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 471853010281 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853010282 dimerization interface [polypeptide binding]; other site 471853010283 putative DNA binding site [nucleotide binding]; other site 471853010284 putative Zn2+ binding site [ion binding]; other site 471853010285 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 471853010286 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853010287 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853010288 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853010289 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853010290 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010291 dimer interface [polypeptide binding]; other site 471853010292 conserved gate region; other site 471853010293 putative PBP binding loops; other site 471853010294 ABC-ATPase subunit interface; other site 471853010295 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 471853010296 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853010297 Walker A/P-loop; other site 471853010298 ATP binding site [chemical binding]; other site 471853010299 Q-loop/lid; other site 471853010300 ABC transporter signature motif; other site 471853010301 Walker B; other site 471853010302 D-loop; other site 471853010303 H-loop/switch region; other site 471853010304 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 471853010305 Walker A/P-loop; other site 471853010306 ATP binding site [chemical binding]; other site 471853010307 Q-loop/lid; other site 471853010308 ABC transporter signature motif; other site 471853010309 Walker B; other site 471853010310 D-loop; other site 471853010311 H-loop/switch region; other site 471853010312 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 471853010313 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 471853010314 active site 471853010315 catalytic site [active] 471853010316 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471853010317 dinuclear metal binding motif [ion binding]; other site 471853010318 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 471853010319 dinuclear metal binding motif [ion binding]; other site 471853010320 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 471853010321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 471853010322 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471853010323 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 471853010324 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 471853010325 DNA binding residues [nucleotide binding] 471853010326 putative dimer interface [polypeptide binding]; other site 471853010327 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853010328 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853010329 active site 471853010330 catalytic tetrad [active] 471853010331 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853010332 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853010333 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010334 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 471853010335 NAD(P) binding site [chemical binding]; other site 471853010336 active site 471853010337 5'-3' exonuclease; Region: 53EXOc; smart00475 471853010338 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 471853010339 active site 471853010340 metal binding site 1 [ion binding]; metal-binding site 471853010341 putative 5' ssDNA interaction site; other site 471853010342 metal binding site 3; metal-binding site 471853010343 metal binding site 2 [ion binding]; metal-binding site 471853010344 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 471853010345 putative DNA binding site [nucleotide binding]; other site 471853010346 putative metal binding site [ion binding]; other site 471853010347 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 471853010348 Protein of unknown function (DUF3618); Region: DUF3618; pfam12277 471853010349 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 471853010350 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 471853010351 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 471853010352 dimerization interface [polypeptide binding]; other site 471853010353 putative ATP binding site [chemical binding]; other site 471853010354 amidophosphoribosyltransferase; Provisional; Region: PRK07847 471853010355 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 471853010356 active site 471853010357 tetramer interface [polypeptide binding]; other site 471853010358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 471853010359 active site 471853010360 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 471853010361 Thioredoxin; Region: Thioredoxin_4; pfam13462 471853010362 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 471853010363 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 471853010364 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 471853010365 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853010366 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 471853010367 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 471853010368 hypothetical protein; Provisional; Region: PRK07877 471853010369 Uncharacterized conserved protein [Function unknown]; Region: COG2128 471853010370 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 471853010371 RNB domain; Region: RNB; pfam00773 471853010372 This domain is the catalytic domain of ribonuclease II; Region: RNB; smart00955 471853010373 pyridoxamine kinase; Validated; Region: PRK05756 471853010374 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 471853010375 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471853010376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853010377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853010378 DNA binding residues [nucleotide binding] 471853010379 ribosome small subunit-dependent GTPase A; Region: TIGR00157 471853010380 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 471853010381 GTPase/Zn-binding domain interface [polypeptide binding]; other site 471853010382 GTP/Mg2+ binding site [chemical binding]; other site 471853010383 G4 box; other site 471853010384 G5 box; other site 471853010385 G1 box; other site 471853010386 Switch I region; other site 471853010387 G2 box; other site 471853010388 G3 box; other site 471853010389 Switch II region; other site 471853010390 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 471853010391 Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281 471853010392 Malic enzyme, N-terminal domain; Region: malic; pfam00390 471853010393 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 471853010394 NAD(P) binding pocket [chemical binding]; other site 471853010395 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 471853010396 Aspartase; Region: Aspartase; cd01357 471853010397 active sites [active] 471853010398 tetramer interface [polypeptide binding]; other site 471853010399 Phosphotransferase enzyme family; Region: APH; pfam01636 471853010400 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853010401 active site 471853010402 ATP binding site [chemical binding]; other site 471853010403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010404 putative substrate translocation pore; other site 471853010405 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010406 RNA polymerase sigma-70 factor, sigma-E family; Region: SigE-fam_strep; TIGR02983 471853010407 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853010408 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853010409 DNA binding residues [nucleotide binding] 471853010410 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 471853010411 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 471853010412 intersubunit interface [polypeptide binding]; other site 471853010413 active site 471853010414 zinc binding site [ion binding]; other site 471853010415 Na+ binding site [ion binding]; other site 471853010416 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 471853010417 putative substrate binding site [chemical binding]; other site 471853010418 putative ATP binding site [chemical binding]; other site 471853010419 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853010420 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471853010421 nucleotide binding site [chemical binding]; other site 471853010422 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 471853010423 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 471853010424 dimer interface [polypeptide binding]; other site 471853010425 active site 471853010426 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 471853010427 dimer interface [polypeptide binding]; other site 471853010428 active site 471853010429 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 471853010430 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 471853010431 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853010432 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853010433 active site 471853010434 phosphorylation site [posttranslational modification] 471853010435 intermolecular recognition site; other site 471853010436 dimerization interface [polypeptide binding]; other site 471853010437 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853010438 dimerization interface [polypeptide binding]; other site 471853010439 DNA binding residues [nucleotide binding] 471853010440 Histidine kinase; Region: HisKA_3; pfam07730 471853010441 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471853010442 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853010443 ATP binding site [chemical binding]; other site 471853010444 Mg2+ binding site [ion binding]; other site 471853010445 G-X-G motif; other site 471853010446 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471853010447 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853010448 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853010449 Walker A/P-loop; other site 471853010450 ATP binding site [chemical binding]; other site 471853010451 Q-loop/lid; other site 471853010452 ABC transporter signature motif; other site 471853010453 Walker B; other site 471853010454 D-loop; other site 471853010455 H-loop/switch region; other site 471853010456 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 471853010457 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 471853010458 dimerization interface [polypeptide binding]; other site 471853010459 ATP binding site [chemical binding]; other site 471853010460 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 471853010461 dimerization interface [polypeptide binding]; other site 471853010462 ATP binding site [chemical binding]; other site 471853010463 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471853010464 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471853010465 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853010466 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853010467 Walker A/P-loop; other site 471853010468 ATP binding site [chemical binding]; other site 471853010469 Q-loop/lid; other site 471853010470 ABC transporter signature motif; other site 471853010471 Walker B; other site 471853010472 D-loop; other site 471853010473 H-loop/switch region; other site 471853010474 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853010475 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471853010476 AAA domain; Region: AAA_33; pfam13671 471853010477 Predicted flavoprotein [General function prediction only]; Region: COG0431 471853010478 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 471853010479 Transcriptional regulators [Transcription]; Region: MarR; COG1846 471853010480 MarR family; Region: MarR_2; pfam12802 471853010481 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853010482 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471853010483 metal binding site [ion binding]; metal-binding site 471853010484 substrate binding pocket [chemical binding]; other site 471853010485 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010487 dimer interface [polypeptide binding]; other site 471853010488 conserved gate region; other site 471853010489 putative PBP binding loops; other site 471853010490 ABC-ATPase subunit interface; other site 471853010491 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853010492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010493 dimer interface [polypeptide binding]; other site 471853010494 conserved gate region; other site 471853010495 putative PBP binding loops; other site 471853010496 ABC-ATPase subunit interface; other site 471853010497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 471853010498 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853010499 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853010500 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 471853010501 Transcriptional regulators [Transcription]; Region: GntR; COG1802 471853010502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 471853010503 DNA-binding site [nucleotide binding]; DNA binding site 471853010504 FCD domain; Region: FCD; pfam07729 471853010505 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471853010506 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471853010507 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 471853010508 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 471853010509 FAD binding pocket [chemical binding]; other site 471853010510 FAD binding motif [chemical binding]; other site 471853010511 phosphate binding motif [ion binding]; other site 471853010512 NAD binding pocket [chemical binding]; other site 471853010513 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 471853010514 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 471853010515 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853010516 active site 471853010517 catalytic residues [active] 471853010518 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12386 471853010519 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 471853010520 catalytic loop [active] 471853010521 iron binding site [ion binding]; other site 471853010522 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07803 471853010523 L-aspartate oxidase; Provisional; Region: PRK06175 471853010524 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 471853010525 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471853010526 acyl-coenzyme A oxidase; Region: PLN02636 471853010527 active site 471853010528 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853010529 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853010530 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 471853010531 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853010532 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853010533 DNA binding site [nucleotide binding] 471853010534 domain linker motif; other site 471853010535 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853010536 ligand binding site [chemical binding]; other site 471853010537 dimerization interface [polypeptide binding]; other site 471853010538 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 471853010539 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853010540 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853010541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010542 dimer interface [polypeptide binding]; other site 471853010543 conserved gate region; other site 471853010544 putative PBP binding loops; other site 471853010545 ABC-ATPase subunit interface; other site 471853010546 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010547 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010548 dimer interface [polypeptide binding]; other site 471853010549 conserved gate region; other site 471853010550 ABC-ATPase subunit interface; other site 471853010551 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 471853010552 Putative glucoamylase; Region: Glycoamylase; pfam10091 471853010553 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 471853010554 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 471853010555 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 471853010556 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471853010557 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471853010558 Biopterin-dependent aromatic amino acid hydroxylase; a family of non-heme, iron(II)-dependent enzymes that includes prokaryotic and eukaryotic phenylalanine-4-hydroxylase (PheOH), eukaryotic tyrosine hydroxylase (TyrOH) and eukaryotic tryptophan...; Region: arom_aa_hydroxylase; cd00361 471853010559 cofactor binding site; other site 471853010560 metal binding site [ion binding]; metal-binding site 471853010561 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471853010562 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 471853010563 putative DNA binding site [nucleotide binding]; other site 471853010564 putative Zn2+ binding site [ion binding]; other site 471853010565 AsnC family; Region: AsnC_trans_reg; pfam01037 471853010566 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853010567 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853010568 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 471853010569 Walker A/P-loop; other site 471853010570 ATP binding site [chemical binding]; other site 471853010571 Q-loop/lid; other site 471853010572 ABC transporter signature motif; other site 471853010573 Walker B; other site 471853010574 D-loop; other site 471853010575 H-loop/switch region; other site 471853010576 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853010577 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853010578 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853010579 Walker A/P-loop; other site 471853010580 ATP binding site [chemical binding]; other site 471853010581 Q-loop/lid; other site 471853010582 ABC transporter signature motif; other site 471853010583 Walker B; other site 471853010584 D-loop; other site 471853010585 H-loop/switch region; other site 471853010586 stage V sporulation protein K; Region: spore_V_K; TIGR02881 471853010587 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853010588 Walker A motif; other site 471853010589 ATP binding site [chemical binding]; other site 471853010590 Walker B motif; other site 471853010591 arginine finger; other site 471853010592 acetyl-CoA acetyltransferase; Provisional; Region: PRK09268 471853010593 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471853010594 dimer interface [polypeptide binding]; other site 471853010595 active site 471853010596 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08261 471853010597 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010598 NAD(P) binding site [chemical binding]; other site 471853010599 active site 471853010600 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 471853010601 active site 2 [active] 471853010602 active site 1 [active] 471853010603 META domain; Region: META; pfam03724 471853010604 META domain; Region: META; cl01245 471853010605 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853010606 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853010607 Coenzyme A binding pocket [chemical binding]; other site 471853010608 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 471853010609 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853010610 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853010611 Coenzyme A binding pocket [chemical binding]; other site 471853010612 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 471853010613 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 471853010614 putative active site [active] 471853010615 catalytic triad [active] 471853010616 phosphoribosylformylglycinamidine synthase subunit PurS; Reviewed; Region: PRK05974 471853010617 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 471853010618 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 471853010619 ATP binding site [chemical binding]; other site 471853010620 active site 471853010621 substrate binding site [chemical binding]; other site 471853010622 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471853010623 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 471853010624 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853010625 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 471853010626 putative NAD(P) binding site [chemical binding]; other site 471853010627 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471853010628 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 471853010629 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 471853010630 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010631 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 471853010632 NAD(P) binding site [chemical binding]; other site 471853010633 active site 471853010634 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 471853010635 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 471853010636 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 471853010637 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 471853010638 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819 471853010639 active site 471853010640 substrate-binding site [chemical binding]; other site 471853010641 metal-binding site [ion binding] 471853010642 GTP binding site [chemical binding]; other site 471853010643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853010644 non-specific DNA binding site [nucleotide binding]; other site 471853010645 salt bridge; other site 471853010646 sequence-specific DNA binding site [nucleotide binding]; other site 471853010647 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 471853010648 PQQ-like domain; Region: PQQ_2; pfam13360 471853010649 Protein of unknown function (DUF402); Region: DUF402; pfam04167 471853010650 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853010651 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853010652 DNA binding site [nucleotide binding] 471853010653 domain linker motif; other site 471853010654 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853010655 dimerization interface [polypeptide binding]; other site 471853010656 ligand binding site [chemical binding]; other site 471853010657 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 471853010658 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853010659 DNA binding residues [nucleotide binding] 471853010660 dimer interface [polypeptide binding]; other site 471853010661 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_14; cd08355 471853010662 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853010663 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853010664 putative dimer interface [polypeptide binding]; other site 471853010665 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 471853010666 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 471853010667 active site 471853010668 Domain of unknown function (DUF718); Region: DUF718; pfam05336 471853010669 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853010670 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853010671 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853010672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010673 dimer interface [polypeptide binding]; other site 471853010674 conserved gate region; other site 471853010675 putative PBP binding loops; other site 471853010676 ABC-ATPase subunit interface; other site 471853010677 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010679 dimer interface [polypeptide binding]; other site 471853010680 ABC-ATPase subunit interface; other site 471853010681 putative PBP binding loops; other site 471853010682 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 471853010683 hexamer (dimer of trimers) interface [polypeptide binding]; other site 471853010684 substrate binding site [chemical binding]; other site 471853010685 trimer interface [polypeptide binding]; other site 471853010686 Mn binding site [ion binding]; other site 471853010687 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 471853010688 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 471853010689 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 471853010690 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 471853010691 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 471853010692 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010694 dimer interface [polypeptide binding]; other site 471853010695 conserved gate region; other site 471853010696 putative PBP binding loops; other site 471853010697 ABC-ATPase subunit interface; other site 471853010698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010699 putative PBP binding loops; other site 471853010700 dimer interface [polypeptide binding]; other site 471853010701 ABC-ATPase subunit interface; other site 471853010702 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853010703 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853010704 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 471853010705 L-rhamnose catabolism isomerase, Pseudomonas stutzeri subtype; Region: L_rham_iso_rhiz; TIGR02629 471853010706 short chain dehydrogenase; Validated; Region: PRK08324 471853010707 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 471853010708 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010709 NAD(P) binding site [chemical binding]; other site 471853010710 active site 471853010711 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 471853010712 N- and C-terminal domain interface [polypeptide binding]; other site 471853010713 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 471853010714 active site 471853010715 putative catalytic site [active] 471853010716 metal binding site [ion binding]; metal-binding site 471853010717 ATP binding site [chemical binding]; other site 471853010718 carbohydrate binding site [chemical binding]; other site 471853010719 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 471853010720 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853010721 active site 471853010722 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 471853010723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853010724 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853010725 active site 471853010726 catalytic tetrad [active] 471853010727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853010728 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 471853010729 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853010730 Walker A/P-loop; other site 471853010731 ATP binding site [chemical binding]; other site 471853010732 Q-loop/lid; other site 471853010733 ABC transporter signature motif; other site 471853010734 Walker B; other site 471853010735 D-loop; other site 471853010736 H-loop/switch region; other site 471853010737 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471853010738 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 471853010739 Staphylococcal nuclease homologue; Region: SNase; pfam00565 471853010740 Catalytic site; other site 471853010741 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 471853010742 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 471853010743 GDP-binding site [chemical binding]; other site 471853010744 ACT binding site; other site 471853010745 IMP binding site; other site 471853010746 Protein of unknown function (DUF3151); Region: DUF3151; pfam11349 471853010747 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471853010748 anti sigma factor interaction site; other site 471853010749 regulatory phosphorylation site [posttranslational modification]; other site 471853010750 PAS domain; Region: PAS_9; pfam13426 471853010751 Sigma factor PP2C-like phosphatases; Region: PP2C_SIG; smart00331 471853010752 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471853010753 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 471853010754 anti sigma factor interaction site; other site 471853010755 regulatory phosphorylation site [posttranslational modification]; other site 471853010756 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 471853010757 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 471853010758 active site 471853010759 intersubunit interface [polypeptide binding]; other site 471853010760 zinc binding site [ion binding]; other site 471853010761 Na+ binding site [ion binding]; other site 471853010762 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 471853010763 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 471853010764 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 471853010765 non-specific DNA binding site [nucleotide binding]; other site 471853010766 salt bridge; other site 471853010767 sequence-specific DNA binding site [nucleotide binding]; other site 471853010768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853010769 UMP phosphatase; Provisional; Region: PRK10444 471853010770 active site 471853010771 motif I; other site 471853010772 motif II; other site 471853010773 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853010774 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 471853010775 orotate phosphoribosyltransferase; Validated; Region: pyrE; PRK00455 471853010776 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 471853010777 classical (c) SDRs; Region: SDR_c; cd05233 471853010778 NAD(P) binding site [chemical binding]; other site 471853010779 active site 471853010780 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 471853010781 putative catalytic site [active] 471853010782 putative phosphate binding site [ion binding]; other site 471853010783 active site 471853010784 metal binding site A [ion binding]; metal-binding site 471853010785 DNA binding site [nucleotide binding] 471853010786 putative AP binding site [nucleotide binding]; other site 471853010787 putative metal binding site B [ion binding]; other site 471853010788 Septum formation; Region: Septum_form; pfam13845 471853010789 Septum formation; Region: Septum_form; pfam13845 471853010790 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853010791 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 471853010792 NAD(P) binding site [chemical binding]; other site 471853010793 active site 471853010794 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 471853010795 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 471853010796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853010797 Walker A motif; other site 471853010798 ATP binding site [chemical binding]; other site 471853010799 Walker B motif; other site 471853010800 arginine finger; other site 471853010801 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853010802 Walker A motif; other site 471853010803 ATP binding site [chemical binding]; other site 471853010804 Walker B motif; other site 471853010805 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 471853010806 MarR family; Region: MarR_2; cl17246 471853010807 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 471853010808 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 471853010809 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cd00596 471853010810 active site 471853010811 Zn binding site [ion binding]; other site 471853010812 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 471853010813 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010814 dimer interface [polypeptide binding]; other site 471853010815 conserved gate region; other site 471853010816 ABC-ATPase subunit interface; other site 471853010817 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 471853010818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010819 dimer interface [polypeptide binding]; other site 471853010820 conserved gate region; other site 471853010821 putative PBP binding loops; other site 471853010822 ABC-ATPase subunit interface; other site 471853010823 Putative FMN-binding domain; Region: FMN_bind_2; cl17803 471853010824 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 471853010825 active site 471853010826 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853010827 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH6; cd08260 471853010828 putative NAD(P) binding site [chemical binding]; other site 471853010829 catalytic Zn binding site [ion binding]; other site 471853010830 structural Zn binding site [ion binding]; other site 471853010831 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 471853010832 catalytic core [active] 471853010833 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853010834 S-adenosylmethionine binding site [chemical binding]; other site 471853010835 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 471853010836 FAD binding domain; Region: FAD_binding_4; pfam01565 471853010837 Berberine and berberine like; Region: BBE; pfam08031 471853010838 RNA polymerase sigma-70 factor, TIGR02957 family; Region: SigX4 471853010839 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853010840 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853010841 DNA binding residues [nucleotide binding] 471853010842 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 471853010843 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 471853010844 protein binding site [polypeptide binding]; other site 471853010845 Amidase; Region: Amidase; cl11426 471853010846 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 471853010847 RNHCP domain; Region: RNHCP; pfam12647 471853010848 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471853010849 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 471853010850 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853010851 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853010852 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 471853010853 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853010854 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853010855 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853010856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010857 dimer interface [polypeptide binding]; other site 471853010858 conserved gate region; other site 471853010859 putative PBP binding loops; other site 471853010860 ABC-ATPase subunit interface; other site 471853010861 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010862 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010863 dimer interface [polypeptide binding]; other site 471853010864 conserved gate region; other site 471853010865 putative PBP binding loops; other site 471853010866 ABC-ATPase subunit interface; other site 471853010867 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 471853010868 putative catalytic site [active] 471853010869 putative metal binding site [ion binding]; other site 471853010870 putative phosphate binding site [ion binding]; other site 471853010871 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 471853010872 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 471853010873 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 471853010874 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 471853010875 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853010876 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471853010877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010878 putative substrate translocation pore; other site 471853010879 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853010880 Cation efflux family; Region: Cation_efflux; pfam01545 471853010881 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 471853010882 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853010883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853010884 Walker A/P-loop; other site 471853010885 ATP binding site [chemical binding]; other site 471853010886 Q-loop/lid; other site 471853010887 ABC transporter signature motif; other site 471853010888 Walker B; other site 471853010889 D-loop; other site 471853010890 H-loop/switch region; other site 471853010891 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853010892 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853010893 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853010894 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853010895 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471853010896 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853010897 dimerization interface [polypeptide binding]; other site 471853010898 putative DNA binding site [nucleotide binding]; other site 471853010899 putative Zn2+ binding site [ion binding]; other site 471853010900 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_6; cd08899 471853010901 putative hydrophobic ligand binding site [chemical binding]; other site 471853010902 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471853010903 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471853010904 Phosphotransferase enzyme family; Region: APH; pfam01636 471853010905 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853010906 active site 471853010907 ATP binding site [chemical binding]; other site 471853010908 substrate binding site [chemical binding]; other site 471853010909 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853010910 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR1; cd08267 471853010911 putative NAD(P) binding site [chemical binding]; other site 471853010912 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471853010913 Clp protease; Region: CLP_protease; pfam00574 471853010914 oligomer interface [polypeptide binding]; other site 471853010915 active site residues [active] 471853010916 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 471853010917 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 471853010918 oligomer interface [polypeptide binding]; other site 471853010919 active site residues [active] 471853010920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 471853010921 sequence-specific DNA binding site [nucleotide binding]; other site 471853010922 salt bridge; other site 471853010923 Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170 471853010924 elongation factor G; Reviewed; Region: PRK12740 471853010925 G1 box; other site 471853010926 putative GEF interaction site [polypeptide binding]; other site 471853010927 GTP/Mg2+ binding site [chemical binding]; other site 471853010928 Switch I region; other site 471853010929 G2 box; other site 471853010930 G3 box; other site 471853010931 Switch II region; other site 471853010932 G4 box; other site 471853010933 G5 box; other site 471853010934 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 471853010935 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 471853010936 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 471853010937 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_9; cd07826 471853010938 putative hydrophobic ligand binding site [chemical binding]; other site 471853010939 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853010940 dimerization interface [polypeptide binding]; other site 471853010941 putative DNA binding site [nucleotide binding]; other site 471853010942 putative Zn2+ binding site [ion binding]; other site 471853010943 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 471853010944 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 471853010945 catalytic residues [active] 471853010946 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 471853010947 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 471853010948 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 471853010949 DNA binding residues [nucleotide binding] 471853010950 putative dimer interface [polypeptide binding]; other site 471853010951 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 471853010952 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 471853010953 HSP70 interaction site [polypeptide binding]; other site 471853010954 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 471853010955 substrate binding site [polypeptide binding]; other site 471853010956 dimer interface [polypeptide binding]; other site 471853010957 GrpE; Region: GrpE; pfam01025 471853010958 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 471853010959 dimer interface [polypeptide binding]; other site 471853010960 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 471853010961 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 471853010962 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853010963 nucleotide binding site [chemical binding]; other site 471853010964 Phosphotransferase enzyme family; Region: APH; pfam01636 471853010965 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853010966 active site 471853010967 ATP binding site [chemical binding]; other site 471853010968 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471853010969 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853010970 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853010971 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853010972 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853010973 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010974 dimer interface [polypeptide binding]; other site 471853010975 conserved gate region; other site 471853010976 putative PBP binding loops; other site 471853010977 ABC-ATPase subunit interface; other site 471853010978 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853010979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853010980 dimer interface [polypeptide binding]; other site 471853010981 conserved gate region; other site 471853010982 putative PBP binding loops; other site 471853010983 ABC-ATPase subunit interface; other site 471853010984 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 471853010985 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 471853010986 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 471853010987 active site 471853010988 catalytic residues [active] 471853010989 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853010990 classical (c) SDRs; Region: SDR_c; cd05233 471853010991 NAD(P) binding site [chemical binding]; other site 471853010992 active site 471853010993 D-mannonate dehydratase (UxuA); Region: UxuA; pfam03786 471853010994 mannonate dehydratase; Region: uxuA; TIGR00695 471853010995 mannonate dehydratase; Region: uxuA; TIGR00695 471853010996 Protein of unknown function (DUF402); Region: DUF402; cl00979 471853010997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853010998 S-adenosylmethionine binding site [chemical binding]; other site 471853010999 Dienelactone hydrolase family; Region: DLH; pfam01738 471853011000 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853011001 dimerization interface [polypeptide binding]; other site 471853011002 putative DNA binding site [nucleotide binding]; other site 471853011003 putative Zn2+ binding site [ion binding]; other site 471853011004 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853011005 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853011006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853011007 Walker A/P-loop; other site 471853011008 ATP binding site [chemical binding]; other site 471853011009 Q-loop/lid; other site 471853011010 ABC transporter signature motif; other site 471853011011 Walker B; other site 471853011012 D-loop; other site 471853011013 H-loop/switch region; other site 471853011014 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 471853011015 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 471853011016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853011017 Q-loop/lid; other site 471853011018 ABC transporter signature motif; other site 471853011019 Walker B; other site 471853011020 D-loop; other site 471853011021 H-loop/switch region; other site 471853011022 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 471853011023 NAD(P) binding site [chemical binding]; other site 471853011024 catalytic residues [active] 471853011025 AAA domain; Region: AAA_33; pfam13671 471853011026 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 471853011027 DinB superfamily; Region: DinB_2; pfam12867 471853011028 Domain of unknown function (DUF4349); Region: DUF4349; pfam14257 471853011029 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471853011030 active site 471853011031 NTP binding site [chemical binding]; other site 471853011032 metal binding triad [ion binding]; metal-binding site 471853011033 Domain of unknown function (DUF222); Region: DUF222; pfam02720 471853011034 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853011035 active site 471853011036 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 471853011037 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988 471853011038 putative acyl-acceptor binding pocket; other site 471853011039 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 471853011040 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 471853011041 putative dimer interface [polypeptide binding]; other site 471853011042 Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076 471853011043 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853011044 catalytic residue [active] 471853011045 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853011046 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471853011047 TPR repeat; Region: TPR_11; pfam13414 471853011048 Predicted transcriptional regulators [Transcription]; Region: COG1733 471853011049 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471853011050 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853011051 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853011052 Protein of unknown function (DUF3626); Region: DUF3626; pfam12294 471853011053 Aminoglycoside/hydroxyurea antibiotic resistance kinase; Region: APH_6_hur; cl17810 471853011054 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 471853011055 coenzyme A binding site [chemical binding]; other site 471853011056 citrylCoA binding site [chemical binding]; other site 471853011057 oxalacetate binding site [chemical binding]; other site 471853011058 catalytic triad [active] 471853011059 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 471853011060 Citrate synthase; Region: Citrate_synt; pfam00285 471853011061 oxalacetate binding site [chemical binding]; other site 471853011062 citrylCoA binding site [chemical binding]; other site 471853011063 coenzyme A binding site [chemical binding]; other site 471853011064 catalytic triad [active] 471853011065 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853011066 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853011067 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 471853011068 active site 471853011069 NTP binding site [chemical binding]; other site 471853011070 metal binding triad [ion binding]; metal-binding site 471853011071 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 471853011072 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 471853011073 catalytic residue [active] 471853011074 putative FPP diphosphate binding site; other site 471853011075 putative FPP binding hydrophobic cleft; other site 471853011076 dimer interface [polypeptide binding]; other site 471853011077 putative IPP diphosphate binding site; other site 471853011078 Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559 471853011079 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853011080 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853011081 Walker A/P-loop; other site 471853011082 ATP binding site [chemical binding]; other site 471853011083 Q-loop/lid; other site 471853011084 ABC transporter signature motif; other site 471853011085 Walker B; other site 471853011086 D-loop; other site 471853011087 H-loop/switch region; other site 471853011088 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 471853011089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853011090 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690 471853011091 nudix motif; other site 471853011092 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853011093 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853011094 Coenzyme A binding pocket [chemical binding]; other site 471853011095 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471853011096 RibD C-terminal domain; Region: RibD_C; cl17279 471853011097 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853011098 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471853011099 YCII-related domain; Region: YCII; cl00999 471853011100 Domain of unknown function (DUF1918); Region: DUF1918; pfam08940 471853011101 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 471853011102 RNA binding surface [nucleotide binding]; other site 471853011103 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853011104 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853011105 DNA-binding site [nucleotide binding]; DNA binding site 471853011106 FCD domain; Region: FCD; pfam07729 471853011107 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 471853011108 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 471853011109 putative active site cavity [active] 471853011110 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853011111 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853011112 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 471853011113 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853011114 inhibitor site; inhibition site 471853011115 active site 471853011116 dimer interface [polypeptide binding]; other site 471853011117 catalytic residue [active] 471853011118 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853011119 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853011120 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853011121 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011123 dimer interface [polypeptide binding]; other site 471853011124 conserved gate region; other site 471853011125 putative PBP binding loops; other site 471853011126 ABC-ATPase subunit interface; other site 471853011127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011128 dimer interface [polypeptide binding]; other site 471853011129 conserved gate region; other site 471853011130 putative PBP binding loops; other site 471853011131 ABC-ATPase subunit interface; other site 471853011132 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853011133 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853011134 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853011135 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853011136 DNA-binding site [nucleotide binding]; DNA binding site 471853011137 FCD domain; Region: FCD; pfam07729 471853011138 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471853011139 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 471853011140 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 471853011141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853011142 active site 471853011143 phosphorylation site [posttranslational modification] 471853011144 intermolecular recognition site; other site 471853011145 dimerization interface [polypeptide binding]; other site 471853011146 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 471853011147 DNA binding site [nucleotide binding] 471853011148 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 471853011149 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 471853011150 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 471853011151 Ligand Binding Site [chemical binding]; other site 471853011152 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 471853011153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 471853011154 dimer interface [polypeptide binding]; other site 471853011155 phosphorylation site [posttranslational modification] 471853011156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853011157 G-X-G motif; other site 471853011158 K+-transporting ATPase, c chain [Inorganic ion transport and metabolism]; Region: KdpC; COG2156 471853011159 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 471853011160 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853011161 Soluble P-type ATPase [General function prediction only]; Region: COG4087 471853011162 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 471853011163 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853011164 Coenzyme A binding pocket [chemical binding]; other site 471853011165 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 471853011166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011167 dimer interface [polypeptide binding]; other site 471853011168 conserved gate region; other site 471853011169 putative PBP binding loops; other site 471853011170 ABC-ATPase subunit interface; other site 471853011171 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 471853011172 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 471853011173 Walker A/P-loop; other site 471853011174 ATP binding site [chemical binding]; other site 471853011175 Q-loop/lid; other site 471853011176 ABC transporter signature motif; other site 471853011177 Walker B; other site 471853011178 D-loop; other site 471853011179 H-loop/switch region; other site 471853011180 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 471853011181 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 471853011182 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011184 dimer interface [polypeptide binding]; other site 471853011185 conserved gate region; other site 471853011186 putative PBP binding loops; other site 471853011187 ABC-ATPase subunit interface; other site 471853011188 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853011189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011190 putative PBP binding loops; other site 471853011191 dimer interface [polypeptide binding]; other site 471853011192 ABC-ATPase subunit interface; other site 471853011193 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853011194 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853011195 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853011196 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853011197 EthD domain; Region: EthD; cl17553 471853011198 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 471853011199 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 471853011200 hypothetical protein; Provisional; Region: PRK02399 471853011201 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853011202 putative DNA binding site [nucleotide binding]; other site 471853011203 putative Zn2+ binding site [ion binding]; other site 471853011204 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853011205 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 471853011206 nucleotide binding site [chemical binding]; other site 471853011207 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853011208 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 471853011209 Domain of unknown function (DUF4185); Region: DUF4185; pfam13810 471853011210 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853011211 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853011212 Walker A/P-loop; other site 471853011213 ATP binding site [chemical binding]; other site 471853011214 Q-loop/lid; other site 471853011215 ABC transporter signature motif; other site 471853011216 Walker B; other site 471853011217 D-loop; other site 471853011218 H-loop/switch region; other site 471853011219 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 471853011220 Histidine kinase; Region: HisKA_3; pfam07730 471853011221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 471853011222 Mg2+ binding site [ion binding]; other site 471853011223 G-X-G motif; other site 471853011224 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853011225 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853011226 active site 471853011227 phosphorylation site [posttranslational modification] 471853011228 intermolecular recognition site; other site 471853011229 dimerization interface [polypeptide binding]; other site 471853011230 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853011231 DNA binding residues [nucleotide binding] 471853011232 dimerization interface [polypeptide binding]; other site 471853011233 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 471853011234 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 471853011235 G1 box; other site 471853011236 GTP/Mg2+ binding site [chemical binding]; other site 471853011237 G2 box; other site 471853011238 Switch I region; other site 471853011239 G3 box; other site 471853011240 Switch II region; other site 471853011241 G4 box; other site 471853011242 G5 box; other site 471853011243 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 471853011244 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 471853011245 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 471853011246 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853011247 Phosphotransferase enzyme family; Region: APH; pfam01636 471853011248 ATP binding site [chemical binding]; other site 471853011249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853011250 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 471853011251 Walker A/P-loop; other site 471853011252 ATP binding site [chemical binding]; other site 471853011253 Q-loop/lid; other site 471853011254 ABC transporter signature motif; other site 471853011255 Walker B; other site 471853011256 D-loop; other site 471853011257 H-loop/switch region; other site 471853011258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011259 ABC-ATPase subunit interface; other site 471853011260 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011261 dimer interface [polypeptide binding]; other site 471853011262 conserved gate region; other site 471853011263 putative PBP binding loops; other site 471853011264 ABC-ATPase subunit interface; other site 471853011265 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 471853011266 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 471853011267 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 471853011268 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 471853011269 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 471853011270 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 471853011271 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12665 471853011272 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471853011273 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07946 471853011274 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12644 471853011275 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 471853011276 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 471853011277 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 471853011278 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853011279 active site 471853011280 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 471853011281 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 471853011282 trimer interface [polypeptide binding]; other site 471853011283 active site 471853011284 Predicted membrane protein [Function unknown]; Region: COG2364 471853011285 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471853011286 TIGR02569 family protein; Region: TIGR02569_actnb 471853011287 Domain of unknown function (DUF385); Region: DUF385; pfam04075 471853011288 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 471853011289 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853011290 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 471853011291 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 471853011292 Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604 471853011293 trimer interface [polypeptide binding]; other site 471853011294 active site 471853011295 homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site 471853011296 catalytic site [active] 471853011297 short chain dehydrogenase; Provisional; Region: PRK06701 471853011298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011299 NAD(P) binding site [chemical binding]; other site 471853011300 active site 471853011301 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 471853011302 Domain of unknown function (DU1801); Region: DUF1801; cl17490 471853011303 RibD C-terminal domain; Region: RibD_C; cl17279 471853011304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853011305 Coenzyme A binding pocket [chemical binding]; other site 471853011306 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 471853011307 putative acyltransferase; Provisional; Region: PRK05790 471853011308 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 471853011309 dimer interface [polypeptide binding]; other site 471853011310 active site 471853011311 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 471853011312 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 471853011313 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 471853011314 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 471853011315 putative active site [active] 471853011316 putative catalytic site [active] 471853011317 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 471853011318 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 471853011319 active site 471853011320 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 471853011321 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 471853011322 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471853011323 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 471853011324 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 471853011325 carboxyltransferase (CT) interaction site; other site 471853011326 biotinylation site [posttranslational modification]; other site 471853011327 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 471853011328 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 471853011329 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471853011330 E3 interaction surface; other site 471853011331 lipoyl attachment site [posttranslational modification]; other site 471853011332 e3 binding domain; Region: E3_binding; pfam02817 471853011333 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 471853011334 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471853011335 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 471853011336 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471853011337 tetramer interface [polypeptide binding]; other site 471853011338 TPP-binding site [chemical binding]; other site 471853011339 heterodimer interface [polypeptide binding]; other site 471853011340 phosphorylation loop region [posttranslational modification] 471853011341 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471853011342 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471853011343 alpha subunit interface [polypeptide binding]; other site 471853011344 TPP binding site [chemical binding]; other site 471853011345 heterodimer interface [polypeptide binding]; other site 471853011346 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471853011347 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 471853011348 AsnC family; Region: AsnC_trans_reg; pfam01037 471853011349 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 471853011350 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853011351 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 471853011352 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 471853011353 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 471853011354 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 471853011355 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 471853011356 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 471853011357 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 471853011358 PPOX class probable F420-dependent enzyme; Region: Rv1155_F420; TIGR03618 471853011359 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 471853011360 active site 471853011361 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 471853011362 active site 471853011363 8-oxo-dGMP binding site [chemical binding]; other site 471853011364 nudix motif; other site 471853011365 metal binding site [ion binding]; metal-binding site 471853011366 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG3571 471853011367 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853011368 putative DNA binding site [nucleotide binding]; other site 471853011369 dimerization interface [polypeptide binding]; other site 471853011370 putative Zn2+ binding site [ion binding]; other site 471853011371 Putative hydrophobic ligand-binding SRPBCC domain of an uncharacterized subgroup of CalC- and Aha1-like proteins; Region: SRPBCC_CalC_Aha1-like_5; cd08898 471853011372 putative hydrophobic ligand binding site [chemical binding]; other site 471853011373 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 471853011374 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853011375 putative substrate translocation pore; other site 471853011376 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853011377 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853011378 YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359 471853011379 Heme oxygenase catalyzes the rate limiting step in the degradation of heme to bilirubin, it is essential for recycling of iron from heme. Heme is used as a substrate and cofactor for its own degradation to biliverdin, iron, and carbon monoxide. This...; Region: HemeO; cd00232 471853011380 heme binding pocket [chemical binding]; other site 471853011381 heme ligand [chemical binding]; other site 471853011382 Predicted membrane protein [Function unknown]; Region: COG1470 471853011383 hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548 471853011384 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853011385 Walker A/P-loop; other site 471853011386 ATP binding site [chemical binding]; other site 471853011387 Q-loop/lid; other site 471853011388 ABC transporter signature motif; other site 471853011389 Walker B; other site 471853011390 D-loop; other site 471853011391 H-loop/switch region; other site 471853011392 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 471853011393 dimer interface [polypeptide binding]; other site 471853011394 putative PBP binding regions; other site 471853011395 ABC-ATPase subunit interface; other site 471853011396 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 471853011397 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 471853011398 intersubunit interface [polypeptide binding]; other site 471853011399 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853011400 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853011401 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 471853011402 short chain dehydrogenase; Validated; Region: PRK05855 471853011403 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471853011404 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471853011405 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853011406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853011407 Walker A/P-loop; other site 471853011408 ATP binding site [chemical binding]; other site 471853011409 Q-loop/lid; other site 471853011410 ABC transporter signature motif; other site 471853011411 Walker B; other site 471853011412 D-loop; other site 471853011413 H-loop/switch region; other site 471853011414 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853011415 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853011416 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853011417 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 471853011418 PA/protease or protease-like domain interface [polypeptide binding]; other site 471853011419 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 471853011420 catalytic residues [active] 471853011421 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 471853011422 Phosphotransferase enzyme family; Region: APH; pfam01636 471853011423 active site 471853011424 substrate binding site [chemical binding]; other site 471853011425 ATP binding site [chemical binding]; other site 471853011426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853011427 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 471853011428 Walker A/P-loop; other site 471853011429 ATP binding site [chemical binding]; other site 471853011430 Q-loop/lid; other site 471853011431 ABC transporter signature motif; other site 471853011432 Walker B; other site 471853011433 D-loop; other site 471853011434 H-loop/switch region; other site 471853011435 Histidine kinase; Region: HisKA_3; pfam07730 471853011436 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853011437 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853011438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853011439 active site 471853011440 phosphorylation site [posttranslational modification] 471853011441 intermolecular recognition site; other site 471853011442 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853011443 DNA binding residues [nucleotide binding] 471853011444 dimerization interface [polypeptide binding]; other site 471853011445 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471853011446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853011447 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853011448 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 471853011449 DNA binding site [nucleotide binding] 471853011450 domain linker motif; other site 471853011451 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853011452 dimerization interface [polypeptide binding]; other site 471853011453 ligand binding site [chemical binding]; other site 471853011454 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011456 dimer interface [polypeptide binding]; other site 471853011457 conserved gate region; other site 471853011458 putative PBP binding loops; other site 471853011459 ABC-ATPase subunit interface; other site 471853011460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011461 dimer interface [polypeptide binding]; other site 471853011462 conserved gate region; other site 471853011463 putative PBP binding loops; other site 471853011464 ABC-ATPase subunit interface; other site 471853011465 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853011466 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853011467 Sulfatase; Region: Sulfatase; cl17466 471853011468 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853011469 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 471853011470 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 471853011471 NHL repeat; Region: NHL; pfam01436 471853011472 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853011473 active site 471853011474 HTH domain; Region: HTH_11; pfam08279 471853011475 WYL domain; Region: WYL; pfam13280 471853011476 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853011477 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 471853011478 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 471853011479 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 471853011480 ATP binding site [chemical binding]; other site 471853011481 putative Mg++ binding site [ion binding]; other site 471853011482 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 471853011483 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853011484 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853011485 Coenzyme A binding pocket [chemical binding]; other site 471853011486 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 471853011487 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 471853011488 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 471853011489 HsdM N-terminal domain; Region: HsdM_N; pfam12161 471853011490 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 471853011491 Methyltransferase domain; Region: Methyltransf_26; pfam13659 471853011492 Protein of unknown function (DUF3892); Region: DUF3892; pfam13031 471853011493 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 471853011494 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 471853011495 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 471853011496 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471853011497 substrate binding pocket [chemical binding]; other site 471853011498 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853011499 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853011500 hexokinase; Provisional; Region: PTZ00107 471853011501 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 471853011502 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853011503 DNA-binding site [nucleotide binding]; DNA binding site 471853011504 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853011505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853011506 homodimer interface [polypeptide binding]; other site 471853011507 catalytic residue [active] 471853011508 Predicted membrane protein [Function unknown]; Region: COG2364 471853011509 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 471853011510 This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333 471853011511 putative deacylase active site [active] 471853011512 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853011513 putative DNA binding site [nucleotide binding]; other site 471853011514 dimerization interface [polypeptide binding]; other site 471853011515 putative Zn2+ binding site [ion binding]; other site 471853011516 Ligand-binding SRPBCC domain of Micromonospora echinospora CalC and related proteins; Region: SRPBCC_CalC; cd08891 471853011517 putative hydrophobic ligand binding site [chemical binding]; other site 471853011518 CLM binding site; other site 471853011519 L1 loop; other site 471853011520 DNA binding site [nucleotide binding] 471853011521 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 471853011522 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 471853011523 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 471853011524 Protein of unknown function (DUF805); Region: DUF805; pfam05656 471853011525 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471853011526 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471853011527 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 471853011528 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 471853011529 Transcriptional regulator [Transcription]; Region: IclR; COG1414 471853011530 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 471853011531 Bacterial transcriptional regulator; Region: IclR; pfam01614 471853011532 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853011533 classical (c) SDRs; Region: SDR_c; cd05233 471853011534 NAD(P) binding site [chemical binding]; other site 471853011535 active site 471853011536 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 471853011537 inhibitor site; inhibition site 471853011538 active site 471853011539 dimer interface [polypeptide binding]; other site 471853011540 catalytic residue [active] 471853011541 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853011542 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853011543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011544 dimer interface [polypeptide binding]; other site 471853011545 putative PBP binding loops; other site 471853011546 ABC-ATPase subunit interface; other site 471853011547 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011549 ABC-ATPase subunit interface; other site 471853011550 putative PBP binding loops; other site 471853011551 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 471853011552 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853011553 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 471853011554 active site pocket [active] 471853011555 Protein of unknown function (DUF2993); Region: DUF2993; pfam11209 471853011556 oxidoreductase; Provisional; Region: PRK12743 471853011557 classical (c) SDRs; Region: SDR_c; cd05233 471853011558 NAD(P) binding site [chemical binding]; other site 471853011559 active site 471853011560 MT0933-like antitoxin protein; Region: MT0933_antitox; pfam14013 471853011561 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853011562 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471853011563 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 471853011564 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 471853011565 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 471853011566 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 471853011567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853011568 S-adenosylmethionine binding site [chemical binding]; other site 471853011569 A domain in the BMP inhibitor chordin and in microbial proteins; Region: CHRD; smart00754 471853011570 Copper resistance protein D; Region: CopD; pfam05425 471853011571 Cytochrome c oxidase caa3 assembly factor (Caa3_CtaG); Region: Caa3_CtaG; pfam09678 471853011572 Phosphotransferase enzyme family; Region: APH; pfam01636 471853011573 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 471853011574 MoxR-like ATPases [General function prediction only]; Region: COG0714 471853011575 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 471853011576 Walker A motif; other site 471853011577 ATP binding site [chemical binding]; other site 471853011578 Walker B motif; other site 471853011579 arginine finger; other site 471853011580 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 471853011581 Protein of unknown function DUF58; Region: DUF58; pfam01882 471853011582 von Willebrand factor type A domain; Region: VWA_2; pfam13519 471853011583 metal ion-dependent adhesion site (MIDAS); other site 471853011584 von Willebrand factor type A domain; Region: VWA_2; pfam13519 471853011585 metal ion-dependent adhesion site (MIDAS); other site 471853011586 Predicted transcriptional regulators [Transcription]; Region: COG1733 471853011587 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471853011588 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 471853011589 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 471853011590 E3 interaction surface; other site 471853011591 lipoyl attachment site [posttranslational modification]; other site 471853011592 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 471853011593 e3 binding domain; Region: E3_binding; pfam02817 471853011594 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 471853011595 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 471853011596 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 471853011597 alpha subunit interface [polypeptide binding]; other site 471853011598 TPP binding site [chemical binding]; other site 471853011599 heterodimer interface [polypeptide binding]; other site 471853011600 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 471853011601 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 471853011602 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 471853011603 TPP-binding site [chemical binding]; other site 471853011604 heterodimer interface [polypeptide binding]; other site 471853011605 tetramer interface [polypeptide binding]; other site 471853011606 phosphorylation loop region [posttranslational modification] 471853011607 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 471853011608 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853011609 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853011610 homodimer interface [polypeptide binding]; other site 471853011611 catalytic residue [active] 471853011612 Predicted membrane protein [Function unknown]; Region: COG1950 471853011613 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 471853011614 Fructosamine kinase; Region: Fructosamin_kin; cl17579 471853011615 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 471853011616 nucleoside/Zn binding site; other site 471853011617 dimer interface [polypeptide binding]; other site 471853011618 catalytic motif [active] 471853011619 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 471853011620 putative dimer interface [polypeptide binding]; other site 471853011621 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853011622 adenylosuccinate lyase; Provisional; Region: PRK09285 471853011623 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 471853011624 tetramer interface [polypeptide binding]; other site 471853011625 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 471853011626 active site 471853011627 metal binding site [ion binding]; metal-binding site 471853011628 AAA domain; Region: AAA_31; pfam13614 471853011629 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853011630 P-loop; other site 471853011631 Magnesium ion binding site [ion binding]; other site 471853011632 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471853011633 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853011634 DNA-binding site [nucleotide binding]; DNA binding site 471853011635 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853011636 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853011637 dimerization interface [polypeptide binding]; other site 471853011638 ligand binding site [chemical binding]; other site 471853011639 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853011640 Sulfatase; Region: Sulfatase; pfam00884 471853011641 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 471853011642 putative DNA binding site [nucleotide binding]; other site 471853011643 putative Zn2+ binding site [ion binding]; other site 471853011644 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 471853011645 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 471853011646 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 471853011647 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853011648 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011649 dimer interface [polypeptide binding]; other site 471853011650 conserved gate region; other site 471853011651 putative PBP binding loops; other site 471853011652 ABC-ATPase subunit interface; other site 471853011653 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011655 dimer interface [polypeptide binding]; other site 471853011656 conserved gate region; other site 471853011657 putative PBP binding loops; other site 471853011658 ABC-ATPase subunit interface; other site 471853011659 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853011660 Sulfatase; Region: Sulfatase; pfam00884 471853011661 PhoD-like phosphatase; Region: PhoD; pfam09423 471853011662 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 471853011663 putative active site [active] 471853011664 putative metal binding site [ion binding]; other site 471853011665 Glycosyl hydrolase family 76; Region: Glyco_hydro_76; cl01996 471853011666 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853011667 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853011668 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011670 dimer interface [polypeptide binding]; other site 471853011671 conserved gate region; other site 471853011672 putative PBP binding loops; other site 471853011673 ABC-ATPase subunit interface; other site 471853011674 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853011675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011676 dimer interface [polypeptide binding]; other site 471853011677 conserved gate region; other site 471853011678 putative PBP binding loops; other site 471853011679 ABC-ATPase subunit interface; other site 471853011680 Uncharacterized conserved protein [Function unknown]; Region: COG3538 471853011681 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 471853011682 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 471853011683 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853011684 Coenzyme A binding pocket [chemical binding]; other site 471853011685 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011687 dimer interface [polypeptide binding]; other site 471853011688 conserved gate region; other site 471853011689 putative PBP binding loops; other site 471853011690 ABC-ATPase subunit interface; other site 471853011691 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011692 dimer interface [polypeptide binding]; other site 471853011693 conserved gate region; other site 471853011694 putative PBP binding loops; other site 471853011695 ABC-ATPase subunit interface; other site 471853011696 carbohydrate ABC transporter, N-acetylglucosamine/diacetylchitobiose-binding protein; Region: chitin_NgcE; TIGR03851 471853011697 hypothetical protein; Provisional; Region: PRK02947 471853011698 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853011699 putative active site [active] 471853011700 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 471853011701 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 471853011702 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 471853011703 putative active site [active] 471853011704 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 471853011705 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853011706 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 471853011707 active site 471853011708 phosphorylation site [posttranslational modification] 471853011709 intermolecular recognition site; other site 471853011710 dimerization interface [polypeptide binding]; other site 471853011711 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853011712 DNA binding residues [nucleotide binding] 471853011713 dimerization interface [polypeptide binding]; other site 471853011714 Histidine kinase; Region: HisKA_3; pfam07730 471853011715 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853011716 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 471853011717 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 471853011718 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 471853011719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853011720 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 471853011721 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 471853011722 Coenzyme A binding pocket [chemical binding]; other site 471853011723 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 471853011724 Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827 471853011725 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 471853011726 NAD(P) binding pocket [chemical binding]; other site 471853011727 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 471853011728 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 471853011729 substrate binding site [chemical binding]; other site 471853011730 active site 471853011731 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 471853011732 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 471853011733 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 471853011734 domain interfaces; other site 471853011735 active site 471853011736 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 471853011737 active site 471853011738 delta-aminolevulinic acid dehydratase; Validated; Region: PRK09283 471853011739 dimer interface [polypeptide binding]; other site 471853011740 active site 471853011741 Schiff base residues; other site 471853011742 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853011743 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 471853011744 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 471853011745 catalytic residue [active] 471853011746 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 471853011747 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 471853011748 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 471853011749 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471853011750 metal-binding site [ion binding] 471853011751 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853011752 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471853011753 metal-binding site [ion binding] 471853011754 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 471853011755 putative homotetramer interface [polypeptide binding]; other site 471853011756 putative homodimer interface [polypeptide binding]; other site 471853011757 putative allosteric switch controlling residues; other site 471853011758 putative metal binding site [ion binding]; other site 471853011759 putative homodimer-homodimer interface [polypeptide binding]; other site 471853011760 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 471853011761 metal-binding site [ion binding] 471853011762 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853011763 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 471853011764 Walker A/P-loop; other site 471853011765 ATP binding site [chemical binding]; other site 471853011766 Q-loop/lid; other site 471853011767 ABC transporter signature motif; other site 471853011768 Walker B; other site 471853011769 D-loop; other site 471853011770 H-loop/switch region; other site 471853011771 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853011772 putative Zn2+ binding site [ion binding]; other site 471853011773 putative DNA binding site [nucleotide binding]; other site 471853011774 CAAX protease self-immunity; Region: Abi; pfam02517 471853011775 2-dehydropantoate 2-reductase; Region: apbA_panE; TIGR00745 471853011776 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 471853011777 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 471853011778 CAAX protease self-immunity; Region: Abi; pfam02517 471853011779 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 471853011780 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 471853011781 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 471853011782 active site 471853011783 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 471853011784 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853011785 galactonate dehydratase; Provisional; Region: PRK14017 471853011786 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471853011787 metal binding site [ion binding]; metal-binding site 471853011788 substrate binding pocket [chemical binding]; other site 471853011789 Carboxylesterase family; Region: COesterase; pfam00135 471853011790 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 471853011791 substrate binding pocket [chemical binding]; other site 471853011792 catalytic triad [active] 471853011793 Transcriptional regulators [Transcription]; Region: FadR; COG2186 471853011794 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853011795 DNA-binding site [nucleotide binding]; DNA binding site 471853011796 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 471853011797 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853011798 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471853011799 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 471853011800 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853011801 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 471853011802 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 471853011803 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011804 dimer interface [polypeptide binding]; other site 471853011805 conserved gate region; other site 471853011806 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 471853011807 ABC-ATPase subunit interface; other site 471853011808 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011810 dimer interface [polypeptide binding]; other site 471853011811 conserved gate region; other site 471853011812 putative PBP binding loops; other site 471853011813 ABC-ATPase subunit interface; other site 471853011814 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853011815 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853011816 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 471853011817 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 471853011818 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 471853011819 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 471853011820 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 471853011821 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 471853011822 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011823 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471853011824 NAD(P) binding site [chemical binding]; other site 471853011825 active site 471853011826 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 471853011827 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 471853011828 active site 471853011829 catalytic site [active] 471853011830 metal binding site [ion binding]; metal-binding site 471853011831 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 471853011832 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 471853011833 CutC family; Region: CutC; cl01218 471853011834 Uncharacterized conserved protein [Function unknown]; Region: COG5476 471853011835 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 471853011836 MlrC C-terminus; Region: MlrC_C; pfam07171 471853011837 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 471853011838 endonuclease III; Region: ENDO3c; smart00478 471853011839 minor groove reading motif; other site 471853011840 helix-hairpin-helix signature motif; other site 471853011841 substrate binding pocket [chemical binding]; other site 471853011842 active site 471853011843 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 471853011844 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 471853011845 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 471853011846 DNA binding site [nucleotide binding] 471853011847 active site 471853011848 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 471853011849 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853011850 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471853011851 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 471853011852 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853011853 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011854 dimer interface [polypeptide binding]; other site 471853011855 conserved gate region; other site 471853011856 putative PBP binding loops; other site 471853011857 ABC-ATPase subunit interface; other site 471853011858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853011859 dimer interface [polypeptide binding]; other site 471853011860 conserved gate region; other site 471853011861 putative PBP binding loops; other site 471853011862 ABC-ATPase subunit interface; other site 471853011863 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853011864 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853011865 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853011866 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853011867 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 471853011868 Transcriptional regulators [Transcription]; Region: PurR; COG1609 471853011869 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 471853011870 dimerization interface [polypeptide binding]; other site 471853011871 ligand binding site [chemical binding]; other site 471853011872 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cl17706 471853011873 substrate binding site [chemical binding]; other site 471853011874 catalytic residues [active] 471853011875 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853011876 S-adenosylmethionine binding site [chemical binding]; other site 471853011877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853011878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853011879 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 471853011880 probable F420-dependent oxidoreductase, Rv1855c family; Region: F420_Rv1855c; TIGR03560 471853011881 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 471853011882 Beta-lactamase; Region: Beta-lactamase; pfam00144 471853011883 Protein of unknown function (DUF1269); Region: DUF1269; cl01978 471853011884 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 471853011885 putative active site [active] 471853011886 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 471853011887 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 471853011888 metal binding site [ion binding]; metal-binding site 471853011889 substrate binding pocket [chemical binding]; other site 471853011890 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853011891 classical (c) SDRs; Region: SDR_c; cd05233 471853011892 NAD(P) binding site [chemical binding]; other site 471853011893 active site 471853011894 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853011895 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853011896 active site 471853011897 catalytic tetrad [active] 471853011898 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853011899 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853011900 active site 471853011901 catalytic tetrad [active] 471853011902 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 471853011903 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 471853011904 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853011905 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471853011906 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 471853011907 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 471853011908 putative hydrophobic ligand binding site [chemical binding]; other site 471853011909 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 471853011910 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 471853011911 Walker A/P-loop; other site 471853011912 ATP binding site [chemical binding]; other site 471853011913 Q-loop/lid; other site 471853011914 ABC transporter signature motif; other site 471853011915 Walker B; other site 471853011916 D-loop; other site 471853011917 H-loop/switch region; other site 471853011918 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 471853011919 daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188 471853011920 Walker A/P-loop; other site 471853011921 ATP binding site [chemical binding]; other site 471853011922 Q-loop/lid; other site 471853011923 ABC transporter signature motif; other site 471853011924 Walker B; other site 471853011925 D-loop; other site 471853011926 H-loop/switch region; other site 471853011927 ABC-2 type transporter; Region: ABC2_membrane; cl17235 471853011928 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 471853011929 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 471853011930 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853011931 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853011932 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 471853011933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853011934 S-adenosylmethionine binding site [chemical binding]; other site 471853011935 YCII-related domain; Region: YCII; cl00999 471853011936 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 471853011937 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853011938 Possible enoyl reductase; Region: MDR_enoyl_red; cd08244 471853011939 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 471853011940 putative NAD(P) binding site [chemical binding]; other site 471853011941 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 471853011942 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 471853011943 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 471853011944 NAD(P) binding pocket [chemical binding]; other site 471853011945 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 471853011946 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 471853011947 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 471853011948 HIGH motif; other site 471853011949 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 471853011950 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 471853011951 active site 471853011952 KMSKS motif; other site 471853011953 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 471853011954 tRNA binding surface [nucleotide binding]; other site 471853011955 anticodon binding site; other site 471853011956 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 471853011957 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 471853011958 Moco binding site; other site 471853011959 metal coordination site [ion binding]; other site 471853011960 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 471853011961 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 471853011962 FAD binding pocket [chemical binding]; other site 471853011963 FAD binding motif [chemical binding]; other site 471853011964 phosphate binding motif [ion binding]; other site 471853011965 beta-alpha-beta structure motif; other site 471853011966 NAD binding pocket [chemical binding]; other site 471853011967 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 471853011968 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 471853011969 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 471853011970 Uncharacterized bacterial proteins with similarity to Aminoglycoside 3'-phosphotransferase (APH) and Choline kinase (ChoK) family members. The APH/ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases; Region: APH_ChoK_like_1; cd05155 471853011971 Phosphotransferase enzyme family; Region: APH; pfam01636 471853011972 putative active site [active] 471853011973 putative substrate binding site [chemical binding]; other site 471853011974 ATP binding site [chemical binding]; other site 471853011975 Domain of unknown function (DU1801); Region: DUF1801; pfam08818 471853011976 DoxX-like family; Region: DoxX_2; pfam13564 471853011977 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853011978 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853011979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853011980 dimerization interface [polypeptide binding]; other site 471853011981 putative DNA binding site [nucleotide binding]; other site 471853011982 putative Zn2+ binding site [ion binding]; other site 471853011983 Predicted transcriptional regulators [Transcription]; Region: COG1733 471853011984 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 471853011985 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471853011986 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 471853011987 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 471853011988 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853011989 NADH(P)-binding; Region: NAD_binding_10; pfam13460 471853011990 NAD(P) binding site [chemical binding]; other site 471853011991 active site 471853011992 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853011993 Sulfatase; Region: Sulfatase; pfam00884 471853011994 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 471853011995 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471853011996 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 471853011997 YCII-related domain; Region: YCII; cl00999 471853011998 Domain of unknown function (DUF1905); Region: DUF1905; pfam08922 471853011999 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 471853012000 Interdomain contacts; other site 471853012001 Cytokine receptor motif; other site 471853012002 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853012003 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853012004 active site 471853012005 catalytic tetrad [active] 471853012006 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 471853012007 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 471853012008 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853012009 catalytic Zn binding site [ion binding]; other site 471853012010 NAD(P) binding site [chemical binding]; other site 471853012011 structural Zn binding site [ion binding]; other site 471853012012 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 471853012013 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 471853012014 active site 471853012015 RibD C-terminal domain; Region: RibD_C; cl17279 471853012016 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 471853012017 Uncharacterized protein conserved in bacteria (DUF2255); Region: DUF2255; cl01788 471853012018 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 471853012019 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 471853012020 active site 471853012021 catalytic tetrad [active] 471853012022 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 471853012023 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 471853012024 DNA binding residues [nucleotide binding] 471853012025 YCII-related domain; Region: YCII; cl00999 471853012026 Protein of unknown function (DUF998); Region: DUF998; pfam06197 471853012027 F0F1-type ATP synthase, beta subunit [Energy production and conversion]; Region: AtpD; COG0055 471853012028 Short C-terminal domain; Region: SHOCT; pfam09851 471853012029 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853012030 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853012031 DNA binding residues [nucleotide binding] 471853012032 dimerization interface [polypeptide binding]; other site 471853012033 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 471853012034 Sulfatase; Region: Sulfatase; pfam00884 471853012035 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 471853012036 Protein of unknown function (DUF664); Region: DUF664; pfam04978 471853012037 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 471853012038 Methyltransferase domain; Region: Methyltransf_23; pfam13489 471853012039 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 471853012040 S-adenosylmethionine binding site [chemical binding]; other site 471853012041 tetracycline repressor protein TetR; Provisional; Region: PRK13756 471853012042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 471853012043 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 471853012044 Major Facilitator Superfamily; Region: MFS_1; pfam07690 471853012045 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853012046 putative substrate translocation pore; other site 471853012047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 471853012048 SnoaL-like domain; Region: SnoaL_4; cl17707 471853012049 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 471853012050 Nuclease subunit of the excinuclease complex [DNA replication, recombination, and repair]; Region: UvrC; COG0322 471853012051 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 471853012052 GIY-YIG motif/motif A; other site 471853012053 active site 471853012054 catalytic site [active] 471853012055 putative DNA binding site [nucleotide binding]; other site 471853012056 metal binding site [ion binding]; metal-binding site 471853012057 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853012058 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 471853012059 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853012060 motif II; other site 471853012061 DoxX-like family; Region: DoxX_2; pfam13564 471853012062 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 471853012063 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 471853012064 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 471853012065 DNA binding residues [nucleotide binding] 471853012066 SnoaL-like domain; Region: SnoaL_2; pfam12680 471853012067 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 471853012068 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 471853012069 M20 Peptidase Aminoacylase 1-like protein 2-like, amidohydrolase subfamily; Region: M20_ACY1L2_like; cd05672 471853012070 metal binding site [ion binding]; metal-binding site 471853012071 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 471853012072 MarR family; Region: MarR; pfam01047 471853012073 Domain of unknown function (DUF385); Region: DUF385; cl04387 471853012074 Part of AAA domain; Region: AAA_19; pfam13245 471853012075 Family description; Region: UvrD_C_2; pfam13538 471853012076 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 471853012077 synthetase active site [active] 471853012078 NTP binding site [chemical binding]; other site 471853012079 metal binding site [ion binding]; metal-binding site 471853012080 Histidine kinase; Region: HisKA_3; pfam07730 471853012081 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 471853012082 ATP binding site [chemical binding]; other site 471853012083 Mg2+ binding site [ion binding]; other site 471853012084 G-X-G motif; other site 471853012085 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 471853012086 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 471853012087 DNA binding residues [nucleotide binding] 471853012088 dimerization interface [polypeptide binding]; other site 471853012089 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853012090 Transcriptional regulator PadR-like family; Region: PadR; cl17335 471853012091 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 471853012092 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 471853012093 Walker A/P-loop; other site 471853012094 ATP binding site [chemical binding]; other site 471853012095 Q-loop/lid; other site 471853012096 ABC transporter signature motif; other site 471853012097 Walker B; other site 471853012098 D-loop; other site 471853012099 H-loop/switch region; other site 471853012100 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 471853012101 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 471853012102 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853012103 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 471853012104 putative DNA binding site [nucleotide binding]; other site 471853012105 putative Zn2+ binding site [ion binding]; other site 471853012106 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 471853012107 putative hydrophobic ligand binding site [chemical binding]; other site 471853012108 Ketosteroid isomerase homolog [Function unknown]; Region: COG4319 471853012109 SnoaL-like domain; Region: SnoaL_3; pfam13474 471853012110 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 471853012111 nucleotide binding site [chemical binding]; other site 471853012112 aspartyl-tRNA synthetase; Provisional; Region: aspC; PRK05159 471853012113 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 471853012114 Dimer interface [polypeptide binding]; other site 471853012115 anticodon binding site; other site 471853012116 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 471853012117 motif 1; other site 471853012118 dimer interface [polypeptide binding]; other site 471853012119 active site 471853012120 motif 2; other site 471853012121 motif 3; other site 471853012122 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 471853012123 Helix-turn-helix domain; Region: HTH_31; pfam13560 471853012124 sequence-specific DNA binding site [nucleotide binding]; other site 471853012125 salt bridge; other site 471853012126 short chain dehydrogenase; Provisional; Region: PRK05854 471853012127 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 471853012128 NAD(P) binding site [chemical binding]; other site 471853012129 active site 471853012130 replicative DNA helicase; Region: DnaB; TIGR00665 471853012131 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 471853012132 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 471853012133 Walker A motif; other site 471853012134 ATP binding site [chemical binding]; other site 471853012135 Walker B motif; other site 471853012136 DNA binding loops [nucleotide binding] 471853012137 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 471853012138 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 471853012139 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 471853012140 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 471853012141 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 471853012142 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 471853012143 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 471853012144 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 471853012145 dimer interface [polypeptide binding]; other site 471853012146 ssDNA binding site [nucleotide binding]; other site 471853012147 tetramer (dimer of dimers) interface [polypeptide binding]; other site 471853012148 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 471853012149 Transglycosylase; Region: Transgly; pfam00912 471853012150 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 471853012151 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 471853012152 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853012153 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 471853012154 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 471853012155 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 471853012156 tetrameric interface [polypeptide binding]; other site 471853012157 NAD binding site [chemical binding]; other site 471853012158 catalytic residues [active] 471853012159 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 471853012160 classical (c) SDRs; Region: SDR_c; cd05233 471853012161 NAD(P) binding site [chemical binding]; other site 471853012162 active site 471853012163 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853012164 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853012165 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853012166 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 471853012167 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 471853012168 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 471853012169 putative NAD(P) binding site [chemical binding]; other site 471853012170 catalytic Zn binding site [ion binding]; other site 471853012171 structural Zn binding site [ion binding]; other site 471853012172 Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863 471853012173 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 471853012174 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 471853012175 substrate binding site [chemical binding]; other site 471853012176 ATP binding site [chemical binding]; other site 471853012177 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 471853012178 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 471853012179 DNA-binding site [nucleotide binding]; DNA binding site 471853012180 UTRA domain; Region: UTRA; pfam07702 471853012181 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 471853012182 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 471853012183 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 471853012184 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 471853012185 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 471853012186 classical (c) SDRs; Region: SDR_c; cd05233 471853012187 NAD(P) binding site [chemical binding]; other site 471853012188 active site 471853012189 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 471853012190 active site 471853012191 catalytic residues [active] 471853012192 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 471853012193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853012194 dimer interface [polypeptide binding]; other site 471853012195 conserved gate region; other site 471853012196 putative PBP binding loops; other site 471853012197 ABC-ATPase subunit interface; other site 471853012198 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 471853012199 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 471853012200 dimer interface [polypeptide binding]; other site 471853012201 conserved gate region; other site 471853012202 putative PBP binding loops; other site 471853012203 ABC-ATPase subunit interface; other site 471853012204 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 471853012205 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 471853012206 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 471853012207 active site 471853012208 Predicted transcriptional regulators [Transcription]; Region: COG1695 471853012209 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 471853012210 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 471853012211 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 471853012212 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 471853012213 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 471853012214 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 471853012215 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 471853012216 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 471853012217 motif II; other site 471853012218 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 471853012219 H+ Antiporter protein; Region: 2A0121; TIGR00900 471853012220 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 471853012221 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 471853012222 Epoxide hydrolase N terminus; Region: EHN; pfam06441 471853012223 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 471853012224 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 471853012225 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 471853012226 active site 471853012227 NTP binding site [chemical binding]; other site 471853012228 metal binding triad [ion binding]; metal-binding site 471853012229 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 471853012230 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 471853012231 Zn2+ binding site [ion binding]; other site 471853012232 Mg2+ binding site [ion binding]; other site 471853012233 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 471853012234 active site 471853012235 Ap6A binding site [chemical binding]; other site 471853012236 nudix motif; other site 471853012237 metal binding site [ion binding]; metal-binding site 471853012238 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 471853012239 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 471853012240 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 471853012241 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 471853012242 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 471853012243 catalytic residues [active] 471853012244 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 471853012245 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 471853012246 pyridoxal 5'-phosphate binding site [chemical binding]; other site 471853012247 homodimer interface [polypeptide binding]; other site 471853012248 catalytic residue [active] 471853012249 D-alanine--D-alanine ligase; Region: D_ala_D_alaTIGR; TIGR01205 471853012250 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 471853012251 ATP-grasp domain; Region: ATP-grasp_4; cl17255 471853012252 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 471853012253 ParB-like nuclease domain; Region: ParB; smart00470 471853012254 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 471853012255 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853012256 P-loop; other site 471853012257 Magnesium ion binding site [ion binding]; other site 471853012258 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 471853012259 Magnesium ion binding site [ion binding]; other site 471853012260 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 471853012261 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 471853012262 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 471853012263 G-X-X-G motif; other site 471853012264 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 471853012265 RxxxH motif; other site 471853012266 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 471853012267 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 471853012268 Haemolytic domain; Region: Haemolytic; pfam01809 471853012269 Ribonuclease P; Region: Ribonuclease_P; cl00457 471853012270 Ribosomal protein L34; Region: Ribosomal_L34; cl00370