-- dump date 20140619_001657 -- class Genbank::CDS -- table cds_note -- id note YP_908864.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_908865.1 binds the polymerase to DNA and acts as a sliding clamp YP_908866.1 COG family: recombinational DNA repair ATPase; Orthologue of BL0637 YP_908867.1 Orthologue of BL0636 YP_908868.1 negatively supercoils closed circular double-stranded DNA YP_908869.1 negatively supercoils closed circular double-stranded DNA YP_908870.1 Orthologue of BL0633 YP_908871.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_908872.1 COG1970; Orthologue of BL1747 YP_908873.1 COG family: predicted metal-dependent hydrolase; COG1451; Orthologue of BL0621; PFAM_ID: DUF45 YP_908874.1 COG family: uncharacterized CBS domain-containing proteins; COG1253; PFAM_ID: CBS; PFAM_ID: DUF21 YP_908875.1 COG family: carbonic anhydrase; COG0288; Orthologue of BL0616; PFAM_ID:Pro_CA YP_908876.1 Identified by sequence similarity; ORF located using Blastx; Orthologue of IL1869_ MHP7448_0272 YP_908877.1 Orthologue of Rv1078 YP_908878.1 Binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30Ssubunit; Identified by similarity to GP:29608270; Orthologue of AF1910_ DET0967 YP_908879.1 Conserved phage-associated protein; Orthologue of PPA1609_ DET1107 YP_908880.1 Orthologue of PPA1609 YP_908881.1 Identified by Glimmer2; putative; Orthologue of DET1106 YP_908882.1 Orthologue of BL0608 YP_908883.1 Orthologue of PPA1591; Peptide glycan binding domain YP_908884.1 Orthologue of BL0607 YP_908885.1 Orthologue of BL0606 YP_908886.1 Orthologue of BL0605 YP_908887.1 Orthologue of BL0604_ Tfu_2554; Phosphoenolpyruvate carboxylase YP_908888.1 COG family: uncharacterized Bcr; Orthologue of BL0603; Uncharacterized BCR YP_908889.1 COG family: Na+_proline_ Na+_panthothenate symporters and related permeases; COG0591; Orthologue of BL0602; PFAM_ID: SSF YP_908890.1 COG family:tryptophanyl-tRNA synthetase; COG0180; Orthologue of BL0600; PFAM_ID: tRNA-synt_1b; Tryptophan-tRNA ligase YP_908891.1 Orthologue of BL0599 YP_908892.1 Orthologue of BL0598 YP_908893.1 COG0058; Orthologue of slr1367_ BL0597 YP_908894.1 Orthologue of jk2069 YP_908895.1 Identified by Glimmer2; putative YP_908897.1 integral membrane protein involved in inhibition of the Z-ring formation YP_908898.1 Orthologue of BL0592 YP_908899.1 Orthologue of BL0591 YP_908900.1 COG family: anthranilate_para- aminobenzoatesynthases component II; Orthologue of BL0590; PFAM_ID: GATase YP_908901.1 COG family: serine_threonine protein kinases; Orthologue of BL0589; PFAM_ID: pkinase YP_908902.1 COG family: serine_threonine protein kinases; Orthologue of BL0588; PFAM_ID: pkinase YP_908903.1 COG family: cell division proteinFtsI_penicillin-binding protein 2; Orthologue of BL0587; PFAM_ID:Transpeptidase YP_908904.1 COG family: bacterial cell divisionmembrane protein; Orthologue of BL0586; PFAM_ID: FTSW_RODA_SPOVE YP_908905.1 COG family: protein serine_threonine phosphatases; Orthologue of BL0585 YP_908906.1 COG family: FHA-domain-containing proteins; Orthologue of BL0584; PFAM_ID: FHA YP_908907.1 COG family: FHA-domain-containing proteins; Orthologue of BL0583; PFAM_ID: FHA YP_908908.1 COG family: dipeptidylaminopeptidases_acylaminoacyl -peptidases; Orthologue of BL0582 YP_908909.1 Orthologue of CE2341 YP_908910.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL0903; PFAM_ID: GerE; PFAM_ID: response_reg YP_908911.1 COG family: lysophospholipase; Orthologue of BL0581; PFAM_ID:abhydrolase YP_908912.1 Orthologue of str1623 YP_908913.1 Identified by match to protein family HMM PF00753; Orthologue of BTH_I2788 YP_908914.1 Orthologue of Ava_2828 YP_908915.1 Orthologue of CAC3033 YP_908916.1 Orthologue of Bcep18194_B2659 YP_908917.1 Orthologue of SAV5329; PF05127: Putative ATPase (DUF699) YP_908918.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL0903; PFAM_ID: GerE; PFAM_ID: response_reg YP_908919.1 COG family: queuine_archaeosinetRNA- ribosyltransferase; Guanine insertion enzyme Tgt; Orthologue of BL0556; PFAM_ID: TGT; tRNA-guanine transglycosylase YP_908920.1 COG family: trypsin-like serineproteases_ typically periplasmic_ contain C-terminal PDZdomain; DegP or HtrA; Orthologue of BL0555; PFAM_ID: PDZ; PFAM_ID: trypsin YP_908921.1 COG family: cation transport ATPases; Orthologue of BL0554; PFAM_ID: Hydrolase; PFAM_ID:E1-E2_ATPase YP_908922.1 Orthologue of PPA0367 YP_908923.1 Orthologue of sll0641 YP_908924.1 COG family: NADPH-dependent glutamatesynthase beta chain and related oxidoreductases; Orthologue of BL0552; PFAM_ID:pyr_redox YP_908925.1 putative metalloprotease YP_908926.1 COG family: permeases of the drug_metabolitetransporter (Dmt) superfamily; Orthologue of BL0575; PFAM_ID: DUF6 YP_908927.1 COG family: predicted membrane protein; Orthologue of BL0137 YP_908928.1 COG family: predicted membrane protein; Orthologue of BL0138 YP_908929.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_908930.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_908931.1 COG family: chloride channel protein EriC; Orthologue of BL0548; PFAM_ID: TrkA; PFAM_ID:voltage_CLC YP_908932.1 COG family: integral membrane protein possiblyinvolved in chromosome condensation; Orthologue of BL1091; PFAM_ID: CRCB YP_908933.1 Orthologue of Tfu_1182 YP_908934.1 Orthologue of Tfu_1183 YP_908935.1 Orthologue of Tfu_1184 YP_908936.1 Orthologue of Tfu_1185 YP_908937.1 Orthologue of Tfu_1186 YP_908938.1 COG family: transcriptional regulators; Orthologue of BL0546; PFAM_ID: Peripla_BP_like; PFAM_ID:lacI YP_908939.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_908940.1 Orthologue of jk0403 YP_908941.1 COG family:glycosidases; Orthologue of BL0536; PFAM_ID: alpha-amylase; Sucrose glucosyltransferase Spl YP_908942.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0534 YP_908943.1 COG family: permeases of the majorfacilitator superfamily; Orthologue of BL0532; PFAM_ID: sugar_tr YP_908944.2 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_908945.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_908946.1 Cytosolic sialic acid; Orthologue of RB10048; Sialic-acid O-acetylesterase; sialic acid-specific9-O-acetylesterase YP_908947.1 Orthologue of BL0152 YP_908948.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL0155; PFAM_ID: DUF214 YP_908949.1 Orthologue of DIP0794; Similar putative integral membrane efflux protein,Na(+)_H(+)antiporter NapA YP_908950.1 COG family: sortase (surface proteintranspeptidase); Orthologue of BL0498 YP_908951.1 COG family: gamma-aminobutyrate permease andrelated permeases; Orthologue of BL0156; PFAM_ID: aa_permeases YP_908952.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_908953.1 catalyzes the adenylation of ThiS which is involved in the formation of 5-methyl-4-(beta-hydroxyethyl)thiazole phosphate YP_908954.1 Orthologue of BL1023 YP_908955.1 COG family: transcriptional regulators; Orthologue of BL0160; PFAM_ID:MarR YP_908956.1 COG family: ABC-type multidrug_protein_lipidtransport system_ ATPase component; Orthologue of BL0162; PFAM_ID: ABC_membrane; PFAM_ID: ABC_tran YP_908957.1 Orthologue of str0434_BL0163 YP_908958.1 Orthologue of lp_3100 YP_908959.1 COG family: membrane-associated lipoproteininvolved in thiamine biosynthesis; Orthologue of BL0164; PFAM_ID: ApbE YP_908960.1 COG family: high-affinity iron permease; Orthologue of BL0455 YP_908961.1 COG family: predicted periplasmic_secreted protein; Orthologue of BL0454 YP_908962.1 Orthologue of BL0453 YP_908963.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL0452; PFAM_ID: DUF214 YP_908964.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL0451; PFAM_ID: DUF214 YP_908965.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL0450; PFAM_ID: ABC_tran YP_908966.1 Orthologue of BL0449 YP_908967.1 COG family: transcriptional regulator; Orthologue of BL0448; PFAM_ID:tetR YP_908968.1 COG family: predicted membrane protein; Orthologue of BL0447 YP_908969.1 COG family: predicted membrane protein; Orthologue of BL0446 YP_908970.1 Orthologue of BL0445 YP_908971.1 Orthologue of BL0439 YP_908972.1 COG family: glycosyltransferases involved in cellwall biogenesis; Orthologue of BL0438; PFAM_ID: Glycos_transf_2 YP_908973.1 COG family: transcriptional regulator; Orthologue of BL0437; PFAM_ID:tetR YP_908974.1 COG family: signalrecognition particle GTPase; Orthologue of BL0436; PFAM_ID: SRP54_N; PFAM_ID:SRP54; docking protein; FtsY YP_908975.1 Orthologue of lp_0400 YP_908976.1 COG family: ammonia permeases; Orthologue of BL0435; PFAM_ID:Ammonium_transp YP_908977.1 COG family: nitrogen regulatory protein pII; Orthologue of BL0434; PFAM_ID: P-II YP_908978.1 COG family: UTP; Orthologue of BL0433; Uridylyl removing enzyme YP_908979.1 COG family: replicative DNA helicase; Orthologue of BL0431; PFAM_ID: DnaB YP_908980.1 COG family: UDP-N-acetylmuramyl tripeptidesynthase; Orthologue of BL0430; PFAM_ID: Mur_ligase YP_908981.1 COG family: predicted glutamine amidotransferase; Orthologue of BL0429 YP_908982.1 COG family: chaperonin GroEL (Hsp60 family); Orthologue of BL0428 YP_908983.1 COG family: predicted unusual protein kinase; Orthologue of BL0427; PFAM_ID: ABC1 YP_908984.1 Orthologue of lmo2085 YP_908985.1 Orthologue of M6_Spy0161 YP_908986.1 COG family: glycerophosphoryl diesterphosphodiesterase; Orthologue of BL1252; PFAM_ID: GDPD YP_908987.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_908988.1 Identified by sequence similarity; Orthologue of Lxx18480 YP_908989.1 COG family: NTP pyrophosphohydrolasesincluding oxidative damage repair enzymes; Orthologue of BL1258; PFAM_ID: NUDIX YP_908990.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_908991.1 COG family: septum formation inhibitor-activatingATPase; Orthologue of BL0509 YP_908992.1 COG family: predicted ATPases involved in pili andflagella biosynthesis_ VirB11 family; Orthologue of BL0508; PFAM_ID: GSPII_E YP_908993.1 Orthologue of BL0507 YP_908994.1 Orthologue of BL0506 YP_908995.1 Orthologue of BL0505 YP_908996.1 Orthologue of BL0504 YP_908997.1 Orthologue of BL0503 YP_908998.1 COG family: uncharacterized Acr; Orthologue of BL0502; PFAM_ID: DAGKc YP_908999.1 COG family: transcriptional regulator; Orthologue of BL0501; PFAM_ID:tetR YP_909000.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_909001.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_909002.1 Aspartokinase alpha subunit; AskA; COG family:aspartokinases; Orthologue of BL0494; PFAM_ID: aakinase YP_909003.1 Aspartokinase beta subunit; AskB; COG family:aspartokinases; Orthologue of BL0493; PFAM_ID: ACT YP_909004.1 catalyzes the formation of aspartate semialdehyde from aspartyl phosphate YP_909005.1 Orthologue of BL0491 YP_909006.1 COG family: serine_threonine protein kinases; Orthologue of HTA426; PFAM_ID: pkinase YP_909007.1 Orthologue of BL0490 YP_909008.1 Orthologue of Rv3710_BL0448; leuA_alpha-isopropylmalate synthase (EC 4.1.3.12) YP_909009.1 Orthologue of BL0184 YP_909010.1 Orthologue of CE1245 YP_909011.1 Orthologue of CE1244 YP_909012.1 Orthologue of BL0184 YP_909013.1 COG family: transcriptional regulators; Orthologue of BL0185; PFAM_ID: Peripla_BP_like; PFAM_ID:lacI YP_909014.1 Identified by Glimmer2; putative; Orthologue of BMAA0057 YP_909015.1 Orthologue of BL0187 YP_909016.1 COG family: sugar-binding periplasmicproteins_domains; Orthologue of BL0188; PFAM_ID: SBP_bacterial_1 YP_909017.1 COG family: ABC-type sugar transport systems_permease components; Orthologue of BL0189; PFAM_ID: BPD_transp YP_909018.1 COG family: sugar permeases; Orthologue of BL0190; PFAM_ID: BPD_transp YP_909019.1 Orthologue of gll2003 YP_909020.1 COG family: membrane carboxypeptidase(penicillin-binding protein); Orthologue of BL0487; PFAM_ID: Transglycosyl; PFAM_ID: Transpeptidase YP_909021.1 Orthologue of Tfu_3099 YP_909022.1 COG family: UDP-galactopyranose mutase; Orthologue of BL1245 YP_909023.1 COG family: membrane-associated phospholipidphosphatase; Orthologue of BL0486; PFAM_ID: PAP2 YP_909024.1 Catalyzes the ATP-dependent breakage ofsignle-stranded DNA followed by passage and rejoining_maintains net negative superhelicity; Orthologue of Rv3646c_BL0485 YP_909025.1 COG family: thymidylate kinase; Orthologue of BL0484; PFAM_ID: Thymidylate_kin; dTMP kinase YP_909026.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_909027.1 Orthologue of SAV5320; Transcriptional regulator mediating carboncatabolite repression YP_909028.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_0065 YP_909029.1 Identified by sequence similarity; Orthologue of Lxx00830 YP_909030.1 Orthologue of SAR0943; Similar to Bacillus subtilis hypothetical protein YxkA YP_909031.1 Orthologue of BL0479 YP_909032.1 COG family: formyltetrahydrofolate synthetase; Orthologue of BL0478; PFAM_ID:FTHFS; formyltetrahydrofolate synthetase YP_909033.1 Orthologue of BL0477 YP_909034.1 COG family: uncharacterized membrane protein; Orthologue of BL0476 YP_909035.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0475 YP_909036.1 COG family: phosphoglyceratemutase_fructose-2_6- bisphosphatase; Orthologue of BL0474; PFAM_ID: PGAM YP_909037.1 Orthologue of BL0473 YP_909038.1 COG family: uncharacterized membrane protein; Orthologue of BL0471 YP_909039.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_909040.1 COG family: predicted phosphohydrolases; Orthologue of BL1260 YP_909041.1 COG family: transcriptional regulator; Orthologue of BL1261; PFAM_ID:IclR YP_909042.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_909043.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_909044.1 Orthologue of GK0575_BL1784 YP_909045.1 COG family: dihydroorotate dehydrogenase; Orthologue of BL1265; PFAM_ID:DHOdehase YP_909046.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_909047.1 COG family: 1-acyl-sn-glycerol-3- phosphateacyltransferase; Orthologue of BL0347; PFAM_ID: Acyltransferase YP_909048.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_909049.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_909050.1 COG family: ABC-type iron_thiamine transportsystems_ periplasmic component; Orthologue of BL0344; PFAM_ID: SBP_bacterial_1 YP_909051.1 COG family: ABC-type spermidine_putrescinetransport system_ permease component I; Orthologue of BL0343 YP_909052.1 COG family: ABC-type spermidine_putrescinetransport system_ permease component II; Orthologue of BL0342 YP_909053.1 COG family: ABC- typesugar_spermidine_putrescine_iron_thiamine transportsystems_ ATPase component; Orthologue of BL0341; PFAM_ID: ABC_tran YP_909054.1 COG family: predicted metal-dependent membraneprotease; Orthologue of BL0340; PFAM_ID: Abi YP_909055.1 COG family: small-conductance mechanosensitivechannel; Orthologue of BL0339; PFAM_ID: MS_channel YP_909056.1 Orthologue of BL0787 YP_909057.1 Orthologue of BL0336 YP_909058.1 COG family: transcriptional regulator; Orthologue of BL0337; PFAM_ID:tetR YP_909059.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_909060.1 similar to full-length Gnd, these proteins seems to have a truncated C-terminal 6PGD domainin; in Methylobacillus flagellatus this gene is essential for NAD+-dependent oxidation of 6-phosphogluconate YP_909061.1 Orthologue of PPA0738 YP_909062.1 Orthologue of SCO1679 YP_909063.1 Orthologue of CE2422 YP_909064.1 Best Blastp Hit: gb|AAC95491.1| (U73025) unknown[Staphylococcus aureus]; Orthologue of SMU.174c YP_909065.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0332 YP_909066.1 required for 70S ribosome assembly YP_909067.1 COG family: RecG-like helicases; Orthologue of BL0329; PFAM_ID: helicase_C; PFAM_ID:DEAD YP_909068.1 COG family: N6-adenine-specific methylase; Orthologue of BL0328 YP_909069.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_909070.1 COG family: RimM protein_ required for 16S rRNAprocessing; Orthologue of BL0307; PFAM_ID: RimM YP_909071.1 COG family: predicted RNA-binding protein (KHdomain); Orthologue of BL0306 YP_909072.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_909073.1 Orthologue of BL0304 YP_909074.1 Identified by sequence similarity; Orthologue of Lxx14950_BL0303 YP_909075.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_909076.1 COG family: GMP synthase - glutamineamidotransferase domain; Orthologue of BL0300; PFAM_ID: GATase YP_909077.1 COG family: ATPase components of ABC transporterswith duplicated ATPase domains; Orthologue of BL0299; PFAM_ID: ABC_tran YP_909078.1 Orthologue of STH1505 YP_909079.1 Orthologue of MAP4318c YP_909080.1 Orthologue of CP000255.1 YP_909081.1 Orthologue of SAV6161 YP_909082.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0759 YP_909083.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_909084.1 acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate YP_909085.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_909086.1 Orthologue of nfa46680 YP_909087.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_909088.1 COG family: predicted metal-binding_ possiblynucleic acid-binding protein; Orthologue of BL0293; PFAM_ID: DUF177 YP_909089.1 Orthologue of BL0292 YP_909090.1 Orthologue of Tfu_2388 YP_909091.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_909092.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_1866 YP_909093.1 COG family: predicted permeases; Orthologue of BL0281 YP_909094.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_909095.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_909096.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_3413 YP_909097.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_909098.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL0932_BL1277; PFAM_ID: ABC_tran YP_909099.1 Orthologue of BL1278 YP_909100.1 COG family: predicted permeases; Orthologue of BL1279 YP_909101.1 catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate YP_909102.1 Orthologue of SCO2599_BL1281; SCC88.10c_ hypothetical protein;N-terminal region similar to TR:P71905 YP_909103.1 COG family: ribosomal protein L21; Orthologue of BL1282; PFAM_ID:Ribosomal_L21p YP_909104.1 involved in the peptidyltransferase reaction during translation YP_909105.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_909106.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_909107.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_909108.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_909109.1 COG family: transcription antiterminator; Orthologue of BL1288; PFAM_ID: NusG YP_909110.1 binds directly to 23S ribosomal RNA YP_909111.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_909112.1 COG family: regulator of polyketide synthaseexpression; Orthologue of BL1531 YP_909113.1 Orthologue of BL1532 YP_909114.1 COG family: biotin-(acetyl-CoA carboxylase) ligase; Orthologue of BL1533; PFAM_ID: BPL_LipA_LipB YP_909115.1 Orthologue of Reut_A0577; Site-specific tyrosine recombinase_ which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. YP_909116.1 COG family: uncharacterized Acr; Orthologue of BL1534; PFAM_ID: BioY YP_909117.1 COG family: biotin carboxylase; Orthologue of BL1535 YP_909118.1 COGfamily: acetyl-CoA carboxylase alpha subunit; Orthologue of BL1536; Propanoyl-CoA:carbon dioxide ligase YP_909119.1 Orthologue of Rv2524c_BL1537; Probable fas_ Fatty Acid Synthase (EC 2.3.1.-) YP_909120.1 COG family: phosphopantetheinyltransferase (holo-acp synthase); Holo-acp synthase; Orthologue of BL1538 YP_909121.1 Orthologue of BL1545 YP_909122.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_909123.1 Orthologue of Rv2783c_BL1546; Probable gpsI_polyribonucleotide nucleotidyltransferase (EC 2.7.7.8;2.7.6.-) YP_909124.1 COG family: uncharacterized Acr; Orthologue of BL0311 YP_909125.1 Orthologue of BL0310 YP_909126.1 Orthologue of BL0310 YP_909127.1 COG family: predicted oxidoreductases (related toaryl-alcohol dehydrogenases); Orthologue of BL0309 YP_909128.1 Orthologue of FN1861 YP_909130.1 COG family: collagenase and related proteases; Orthologue of BL0326; PFAM_ID: Peptidase_U32 YP_909131.1 COG family: uncharacterized Acr; Orthologue of BL0325; PFAM_ID: DUF152 YP_909132.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; COGfamily: 4-diphosphocytidyl-2-methyl-D- erithritol synthase; Orthologue of BL0324; PFAM_ID: UPF0007 YP_909133.1 5-oxoprolyl-peptidase; COG family: pyrrolidone-carboxylatepeptidase (N-terminal pyroglutamyl peptidase); Orthologue of BL0323; PFAM_ID:Peptidase_C15; Pyroglutamyl-peptidase I YP_909134.1 COG family: methyl-accepting chemotaxis protein; Orthologue of BL0322 YP_909135.1 COG family: aminopeptidase C; Orthologue of BL0321; PFAM_ID:Pept_C1-like YP_909136.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_909137.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_909138.1 COG family: nucleoside phosphorylase; Orthologue of BL0318; PFAM_ID:PNP_UDP_1 YP_909139.1 COG family: sensory transduction histidine kinases; Orthologue of BL0317; PFAM_ID: HATPase_c; PFAM_ID: signal YP_909140.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL0316; PFAM_ID: response_reg; PFAM_ID: trans_reg_C YP_909141.1 COG family: ABC-type phosphate transportsystem_ periplasmic component; Orthologue of BL0315; PFAM_ID: PstS YP_909142.1 COG family: ABC-type phosphate transportsystem_ permease component; Orthologue of BL0314; PFAM_ID: BPD_transp YP_909143.1 COG family: ABC-type phosphate transportsystem_ permease component; Orthologue of BL0313; PFAM_ID: BPD_transp YP_909144.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_909145.1 COG family: ABC-type Mn_Zn transport system_periplasmic Mn_Zn-binding (lipo)protein (surface adhesina); Orthologue of BL1126; PFAM_ID: Lipoprotein_4 YP_909146.1 COG family: permeases; Orthologue of BL1547; PFAM_ID: xan_ur_permease YP_909147.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_909148.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_909149.1 Orthologue of BL1551 YP_909150.1 COG family: superfamily I DNA and RNA helicases andhelicase subunits; Orthologue of BL1552 YP_909151.1 Orthologue of BL1553 YP_909152.1 COG family: 5-formyltetrahydrofolate cyclo-ligase; Orthologue of BL1555; PFAM_ID: 5-FTHF_cyc-lig YP_909153.1 COG family: acetyltransferases_ includingN-acetylases of ribosomal proteins; Orthologue of BL1556; PFAM_ID: Acetyltransf YP_909154.1 Orthologue of BL1557 YP_909155.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_909156.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif YP_909157.1 Orthologue of BL1561; PFAM_ID: MurB; UDP-N-acetylmuramate dehydrogenase; MurB; COGfamily: UDP-N-acetylmuramate dehydrogenase YP_909158.1 COG family: amino acid transporters; Orthologue of BL1562; PFAM_ID:aa_permeases YP_909159.1 COG family: ferredoxin 3; Orthologue of BL1563; PFAM_ID: fer4 YP_909160.1 catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis YP_909161.1 Identified by Glimmer2; putative; Orthologue of CPS_1689 YP_909162.1 Orthologue of BF2899; Very low similarity to the C-terminal region ofCytophaga xylanolytica ArfI YP_909163.1 Orthologue of BH2105 YP_909164.1 Orthologue of BF0575_BH2105; Similar to Caldocellum saccharolyticum xylanaseXynF YP_909165.1 ORF_ID:slr8023probable esterase; Orthologue of slr8023 YP_909166.1 COG family: nucleotidyltransferase_DNA polymeraseinvolved in DNA repair; Orthologue of BL1565; PFAM_ID: IMS YP_909167.1 COG family: putative enzyme of poly-gamma-glutamatebiosynthesis (capsule formation); Orthologue of BL1567 YP_909168.1 COG family: phosphoglycerate dehydrogenase andrelated dehydrogenases; Orthologue of BL1568; PFAM_ID: 2-Hacid_DH_C YP_909169.1 COG family: uncharacterized Acr; Orthologue of BL1569; PFAM_ID: UPF0029 YP_909170.1 Ccontains a conserved domain in cyanobacteria. Samedomain in Pro0575_ Pro0618_ Pro01459; Orthologue of Pro0615 YP_909171.1 Amylomaltase; COG family:4-alpha-glucanotransferase; Orthologue of BL1570; PFAM_ID: 4A_glucanotrans YP_909172.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_909173.1 forms a direct contact with the tRNA during translation YP_909174.1 COG family: pullulanase and related glycosidases; Orthologue of BL1573; PFAM_ID: alpha-amylase; PFAM_ID: isoamylase_N YP_909176.1 Orthologue of SCO1901; Probable zinc-binding dehydrogenase YP_909177.1 Orthologue of BLi04061 YP_909178.1 COG family: transcriptional regulators; Orthologue of BL1574; PFAM_ID:ROK YP_909179.1 Orthologue of SH0209; Ribitol transporter homolog YP_909180.1 Orthologue of mlr4915 YP_909181.1 AraC family; Identified by match to protein family HMM PF00165; Orthologue of PSPPH_4841 YP_909182.1 Acetaldehyde dehydrogenase; Orthologue of ECs1741; Similar to ADHE_ECOLI gi|1787493 (conserved in Escherichia coli K-12) YP_909183.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_909184.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_909185.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_909186.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_909187.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_909188.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_909189.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_909190.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_909191.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_909192.1 COG family: ribosomal protein L29; Orthologue of BL1587; PFAM_ID: Ribosomal_L29 YP_909193.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_909194.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_909195.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_909196.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_909197.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif YP_909198.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_909199.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_909200.1 binds 5S rRNA along with protein L5 and L25 YP_909201.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_909202.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_909203.1 late assembly protein YP_909204.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_909205.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_909206.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_909207.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_909208.2 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_909209.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_909210.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_909211.1 is a component of the macrolide binding site in the peptidyl transferase center YP_909212.1 COG family: pseudouridylatesynthase (tRNA psi55); Orthologue of BL1608; PFAM_ID: PseudoU_synth_1; Pseudouridylate synthase I; Uuracil hydrolyase YP_909213.1 COG family: uncharacterized Bcr; Orthologue of BL1609 YP_909214.1 COG family: transglutaminase-like enzymes_ putativecysteine proteases; Orthologue of BL1610; PFAM_ID: Transglut_core YP_909215.1 Orthologue of BL1614 YP_909216.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_909217.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_909218.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_909219.1 COGfamily: pseudouridine synthase; Orthologue of BL1618; PFAM_ID: TruB_N; Uracil hydrolyase YP_909220.1 COGfamily: FAD synthase; Fad pyrophosphorylase; Fad synthetase; Orthologue of BL1619; PFAM_ID: FAD_Synth YP_909221.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_909222.1 Orthologue of BL1621 YP_909223.1 Orthologue of BL1622 YP_909224.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_909225.1 COG family: ribonuclease HI; Orthologue of BL1624; PFAM_ID:RNaseH YP_909226.1 Orthologue of lin0802 YP_909227.1 Orthologue of OB1641 YP_909228.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_909229.1 COG family:phosphotransferase system IIb components; Glucose-permease IIABC; Orthologue of BL1632; PFAM_ID: PTS_EIIA_1; PFAM_ID: PTS_EIIC; PFAM_ID:PTS_EIIB; Phosphotransferase enzymeII_ ABC component YP_909230.1 Orthologue of BL1633 YP_909231.1 COG family: uncharacterized Acr; Orthologue of BL1634; PFAM_ID: DAGKc YP_909232.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_909233.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL1645; PFAM_ID: GerE; PFAM_ID: response_reg YP_909234.1 COG family: sensory transduction histidine kinases; Orthologue of BL1646 YP_909235.1 COG family: putative stress-responsivetranscriptional regulator; Orthologue of BL1647 YP_909236.1 Orthologue of BL1648 YP_909237.1 Orthologue of BL1649 YP_909238.1 COG family: arabinose efflux permease; Orthologue of BL1652; PFAM_ID:sugar_tr YP_909239.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_909240.1 COG family: 1_4-dihydroxy-2- naphthoateoctaprenyltransferase; Orthologue of BL1655; PFAM_ID: UbiA YP_909241.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_909242.1 in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever YP_909243.1 COG family: phosphate uptake regulator; Orthologue of BL1657 YP_909244.1 COG family: sensory transduction histidine kinases; Orthologue of BL1658; PFAM_ID: HATPase_c YP_909245.1 Orthologue of BL1659 YP_909246.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate YP_909247.1 Orthologue of BL1661 YP_909248.1 COG family: cell wall-associated hydrolases(invasion-associated proteins); Orthologue of BL1663; PFAM_ID: NLPC_P60 YP_909249.1 COG family: universal stress protein UspA andrelated nucleotide-binding proteins; Orthologue of BL1664; PFAM_ID: Usp YP_909250.1 Orthologue of BL1664a YP_909251.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_909252.1 COG family: dihydrofolate reductase; Orthologue of BL1666; PFAM_ID:DiHfolate_red YP_909253.1 COG family:protein-tyrosine-phosphatase; Orthologue of BL1667; PFAM_ID: LMWPc; Small_ acidic phosphotyrosine proteinphosphatase YP_909254.1 COG family: UDP-glucose 4-epimerase; Galactowaldenase; Orthologue of BL1671; PFAM_ID: 3Beta_HSD; PFAM_ID: Epimerase; UDP-galactose 4-epimerase YP_909255.1 COG family: predicted S-adenosylmethionine-dependent methyltransferase; Orthologue of BL1670; PFAM_ID:Methyltransf_4 YP_909256.1 Orthologue of CAC0731 YP_909257.1 Orthologue of CAC0732 YP_909258.1 Orthologue of CAC0733 YP_909259.1 Lipopolysaccharide biosynthesis protein-related protein; Orthologue of CAC0734 YP_909260.1 Orthologue of CAC0735 YP_909261.1 Orthologue of BCZK1852 YP_909262.1 Orthologue of OB2513 YP_909263.1 Orthologue of BCZK4489 YP_909264.1 Orthologue of YPTB2321; Similar to Escherichia coli b1706 hypothetical protein YP_909265.1 Orthologue of BURPS1710b_1550 YP_909266.1 COG family:alcohol dehydrogenase IV; Orthologue of BL1673; PFAM_ID: Fe-ADH; Propanediol oxidoreductase YP_909267.1 COG family: glycosyltransferases involved in cellwall biogenesis; Orthologue of BL1674; PFAM_ID: Glycos_transf_2 YP_909268.1 COG family: predicted permease; Orthologue of BL1675; PFAM_ID: UPF0118 YP_909269.1 COG family: glycosyltransferases_ probably involvedin cell wall biogenesis; Orthologue of BL1676; PFAM_ID: Glycos_transf_2 YP_909270.1 COG family: D-alanyl-D-alanine carboxypeptidase(penicillin-binding protein 4); Orthologue of BL1679; PFAM_ID: Peptidase_S13 YP_909271.1 COG family: hypoxanthine- guaninephosphoribosyltransferase; Orthologue of BL1681; PFAM_ID: Pribosyltran YP_909273.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_909274.1 COGfamily: dihydropteroate synthase; Dihydropteroate pyrophosphorylase 1; Orthologue of BL1684; PFAM_ID: DHPS YP_909275.1 7_8-dihydro-6- hydroxymethylpterinpyrophosphokinase; HppK; COG family: dihydroneopterinaldolase; Orthologue of BL1685; PFAM_ID: FolB; PFAM_ID: HPPK YP_909276.1 Orthologue of BL1686 YP_909277.1 COG family: acyl-CoA thioesterase; Orthologue of BL1687; PFAM_ID: Acyl_CoA_thio YP_909278.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_909279.1 Orthologue of SCO4877 YP_909280.1 Escherichia coli ECs4838 transcriptional regulator in 2-component system CpxR; Orthologue of YPTB0070; Similar to Yersinia pestis YPO0074 cpxR YP_909281.1 Orthologue of SAK_0872; identified by similarity to SP:P17618 YP_909282.1 COG family: predicted metal-dependent hydrolasewith the TIM-barrel fold; Orthologue of BL0601 YP_909283.1 Orthologue of BL0019 YP_909284.1 Orthologue of BT1923 YP_909285.1 catalyzes the interconversion of D-xylose to D-xylulose YP_909286.1 Includes: beta-xylosidase; Orthologue of ABC1148 YP_909287.1 Orthologue of SAV4983 YP_909288.1 Orthologue of SAV4979 YP_909289.1 Orthologue of SAV4980 YP_909290.1 Orthologue of SAV4981 YP_909291.1 Orthologue of L0234; intracellular xylan-degrading enzyme YP_909292.1 Orthologue of XCV4334 YP_909293.1 Orthologue of bll4001 YP_909294.1 Orthologue of Tfu_1260 YP_909295.1 COG family: sugar (pentuloseand hexulose) kinases; Orthologue of BL1709; PFAM_ID: FGGY; Xylulokinase YP_909296.1 COG family: transcriptional regulators; Orthologue of BL1710; PFAM_ID:ROK YP_909297.1 Orthologue of MAP0607c YP_909298.1 Orthologue of BH3701 YP_909299.1 Glucose kinase; Orthologue of LBA1367 YP_909300.1 COG family: transcriptional regulator; Orthologue of BL1756; PFAM_ID:tetR YP_909301.1 COG family: esterase_lipase; Orthologue of BL0682 YP_909302.1 Orthologue of TM1848; Similar to GP:3184120 percent identity: 97.66;identified by sequence similarity YP_909303.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_909304.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_909305.1 COG family: predicted rRNA or tRNA methylase; Orthologue of BL1713 YP_909306.1 COG family: ABC-type branched-chain amino acidtransport systems_ periplasmic component; Orthologue of BL1714 YP_909307.1 COG family: branched-chain amino acid ABC-typetransport system_ permease components; Orthologue of BL1715 YP_909308.1 COG family: branched-chain amino acid ABC-typetransport system_ permease components; Orthologue of BL1716 YP_909309.1 COG family: ABC-type branched-chain amino acidtransport systems_ ATPase component; Orthologue of BL1717 YP_909310.1 COG family: ABC-type branched-chain amino acidtransport systems_ ATPase component; Orthologue of BL1718 YP_909311.1 COG family: putative translation factor (Sua5); Orthologue of BL1720; PFAM_ID: Sua5_yciO_yrdC YP_909312.1 COG family: UDP-N-acetylmuramyl pentapeptidephosphotransferase_UDP-N-acetylglucosamine-1- phosphatetransferase; Orthologue of BL1721 YP_909313.1 Identified by sequence similarity; Orthologue of Lxx19860_BL1722 YP_909314.1 COG family: transcriptional regulators; Orthologue of BL0528; PFAM_ID:lacI YP_909315.1 COG family: glycosidases; Maltase-like enzyme; Orthologue of BL0529; PFAM_ID:alpha-amylase YP_909316.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_909317.1 Orthologue of SAV4444; PF00702: haloacid dehalogenase-like hydrolase YP_909318.1 COG family: ATP-dependent exoDNase (exonuclease V)_alpha subunit - helicase superfamily I member; Orthologue of BL1724 YP_909319.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_909320.1 COG family: single-stranded DNA-binding protein; Orthologue of BL1729; PFAM_ID: SSB YP_909321.1 COG family: predictedmetalloendopeptidase; Orthologue of BL1730; PFAM_ID: Peptidase_M13; Zinc metalloprotease YP_909322.1 COG family: methionineaminopeptidase; Orthologue of BL1732; PFAM_ID: Peptidase_M24 YP_909323.1 COG family: citrate synthase; Orthologue of BL1733 YP_909324.1 COG family: tetrahydrodipicolinateN- succinyltransferase; Orthologue of BL1734 YP_909325.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_909326.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_909327.1 COG family: predicted ATPase involved in celldivision; Orthologue of BL1183 YP_909328.1 COG family: cell division protein; Orthologue of BL1182; PFAM_ID:DUF214 YP_909329.1 Orthologue of BL1181 YP_909330.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_909331.1 COG family: ABC-type amino acid transport system_periplasmic component; Orthologue of BL1179_BL1178 YP_909332.1 COG family: ABC-type amino acid transport system_periplasmic component; Orthologue of BL1179_BL1178 YP_909333.1 COG family: ABC-type amino acid transport system_periplasmic component; Orthologue of BL1179_BL1178 YP_909334.1 COG family: ABC-type amino acid transport system_permease component; Orthologue of BL1177 YP_909335.1 COG family: ABC-type polar amino acid transportsystem_ ATPase component; Orthologue of BL1176 YP_909336.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_909337.1 COG family: pseudouridylate synthases_ 23SRNA-specific; Orthologue of BL1174; RNA-uridine isomerase_RNA pseudouridylate synthase YP_909338.1 involved in the import of serine and threonine coupled with the import of sodium YP_909339.1 COG family: sugar-binding periplasmicproteins_domains; Orthologue of BL1163 YP_909340.1 type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP YP_909341.1 Orthologue of SH1703; Phosphopantothenate-cysteine ligase; Ppantothenate metabolism flavoprotein homolog YP_909342.1 COG family: ABC-type dipeptide_oligopeptide_nickeltransport systems_ periplasmic components; Orthologue of BL1161 YP_909343.1 COG family: ABC-type dipeptide_oligopeptide_nickeltransport systems_ permease components; Orthologue of BL1160 YP_909344.1 COG family: ABC-type dipeptide_oligopeptide_nickeltransport systems_ permease components; Orthologue of BL1159 YP_909345.1 COG family: ATPase components of variousABC-type transport systems_ contain duplicated ATPase; Orthologue of BL1158 YP_909346.1 COG family: ATPase components of variousABC-type transport systems_ contain duplicated ATPase; Orthologue of BL1157 YP_909347.1 Orthologue of Lxx17750 YP_909348.1 Orthologue of Lxx17740 YP_909349.1 ATP-binding protein; Identified by sequence similarity; Orthologue of Lxx18820 YP_909350.1 Orthologue of Lxx17710 YP_909351.1 ATP-binding protein; Orthologue of lp_2743 YP_909352.1 Orthologue of STY4758; Similar to Escherichia coli hypothetical 35.5 kDa protein in rpli-cpdb intergenic region ytfF SW:YTFF_ECOLI(P39314)Contains possible membrane spanning hydrophobic domains YP_909353.1 Beta-thionase; COGfamily: cysteine synthase; Orthologue of BL1156; PFAM_ID: PALP; serine sulfhydrase YP_909354.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_909355.1 COG family: superfamily II DNA helicase; Orthologue of BL1153; PFAM_ID: HRDC; PFAM_ID: helicase_C; PFAM_ID:DEAD YP_909356.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_909357.1 Orthologue of BL1151 YP_909358.1 COG family: amino acid transporters; Orthologue of BL1150; PFAM_ID:aa_permeases YP_909359.1 COG family: alanine racemase; Orthologue of BL1149; PFAM_ID:Ala_racemase YP_909360.1 dGTPase family type 2 subfamily; presumably hydrolyzes dGTP to deoxyguanosine and triphosphate YP_909361.1 synthesizes RNA primers at the replication forks YP_909362.1 COG family: di- and tricarboxylate transporters; Orthologue of BL1140 YP_909363.1 Orthologue of lp_2696 YP_909364.1 GTPase; Orthologue of LBA0051 YP_909365.1 COG family: histone acetyltransferase Hpa2 andrelated acetyltransferases; Orthologue of BL0130; PFAM_ID: Acetyltransf YP_909366.1 COG family: ABC-type amino acid transport system_permease component; Orthologue of BL0074; PFAM_ID: BPD_transp YP_909367.1 COG family: ABC-type amino acid transport system_permease component; Orthologue of BL0075; PFAM_ID: BPD_transp YP_909368.1 COG family: ABC-type polar amino acidtransport system_ ATPase component; Orthologue of BL0076; PFAM_ID: ABC_tran YP_909369.1 COG family: ABC-type amino acid transport system_periplasmic component; Orthologue of BL0077; PFAM_ID: SBP_bac_3 YP_909370.1 Beta-cystathionase; COG family: cystathioninebeta-lyases_cystathionine gamma-synthases; Orthologue of BL0078; PFAM_ID:Cys_Met_Meta_PP YP_909371.1 COG family: membrane protease subunits_stomatin_prohibitin homologs; Orthologue of BL0084; PFAM_ID: Band_7 YP_909372.1 Orthologue of ABC3794 YP_909373.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL1135; PFAM_ID: ABC_tran YP_909374.1 COG family: S-layer domain; Orthologue of BL1134 YP_909375.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL1133; PFAM_ID: DUF214 YP_909376.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_909377.1 COG family: NADPH; Orthologue of BL1131; PFAM_ID: adh_zinc; Quinone oxidoreductase YP_909378.1 Air carboxylase AirC; COG family:phosphoribosylcarboxyaminoimidazole (ncair) mutase; Orthologue of BL1130; PFAM_ID: AIRC YP_909379.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_909380.1 COG family: Fe2+_Zn2+ uptake regulationproteins; Orthologue of BL1128; PFAM_ID: FUR YP_909381.1 COG family: phosphoglycerol transferase and relatedproteins_ alkaline phosphatase superfamily; Orthologue of BL1125 YP_909382.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_909383.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_909384.1 Catalyzes first step of the de novo purinenucleotide biosynthetic pathway; Orthologue of ABC1031_BL1121 YP_909385.1 COG family: nucleotidyltransferase_DNA polymeraseinvolved in DNA repair; Orthologue of BL1114; PFAM_ID: IMS YP_909386.1 Bifunctional enzyme; Orthologue of CAC1655_BL1108 YP_909387.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_909388.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_909389.1 COG family: predicted glycosyltransferases; Orthologue of BL1104; PFAM_ID: Glycos_transf_1 YP_909390.1 COG family: threonine aldolase; Orthologue of BL1103 YP_909391.1 COG family: predicted Na+-dependent transporter; Orthologue of BL1102; PFAM_ID: SBF YP_909392.1 Orthologue of BPSL0772_BL1101 YP_909393.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_909394.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_909395.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_909396.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_909397.1 Orthologue of c5233 YP_909398.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_909399.1 Composed of two chains; the small (or glutamine)chain promotes the hydrolysis of glutamine to ammonia_which is used by the large (or ammonia) chain tosynthesize carbamoyl phosphate; binds manganese; involvedin pyrimidine synthesis; Orthologue of Rv1384_BL0068 YP_909400.1 COG family:orotidine-5'-phosphate decarboxylase; Omp decarboxylase; Ompdcase; Orthologue of BL0069 YP_909401.1 Essential for recycling GMP and indirectly, cGMP YP_909402.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_909403.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_909404.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_909405.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_909406.1 COG family: predicted hydrolases of the Hadsuperfamily; Orthologue of BL1790; PFAM_ID: Hydrolase YP_909407.1 COG family: methionyl-tRNA formyltransferase; Orthologue of BL1789; PFAM_ID: formyl_transf YP_909408.1 COG family: phosphoserine phosphatase; Orthologue of BL1792; PFAM_ID:Hydrolase; Psp:O-phosphoserine phosphohydrolase YP_909409.1 COG family: ATPases of the Aaa+ class; Orthologue of BL1794; PFAM_ID:AAA YP_909410.1 Orthologue of BL1795 YP_909411.1 COG family: archaeal fructose-1_6-bisphosphataseand related enzymes of inositol monophosphatase family; Orthologue of BL1796; PFAM_ID: inositol_P YP_909412.1 Orthologue of BL1797 YP_909413.1 Orthologue of BL1086 YP_909414.1 COG family: transcriptional regulators; Orthologue of BL1087; PFAM_ID:MarR YP_909415.1 COG family: bacterial nucleoidDNA-binding protein; Orthologue of BL1798; PFAM_ID: Bac_DNA_binding YP_909416.1 COG family: predicted integral membrane protein; Orthologue of BL1799 YP_909417.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_909418.1 Orthologue of BL1804 YP_909419.1 Orthologue of BL1805 YP_909420.1 Orthologue of SH1431 YP_909421.1 COG family: uncharacterized Bcr; Orthologue of BL1807 YP_909422.1 COG family: uncharacterized Bcr; Orthologue of BL1808 YP_909423.1 Orthologue of BL1809 YP_909424.1 COG family: uncharacterized Acr; Orthologue of BL1810 YP_909425.1 COG family: MoxR-like ATPases; Orthologue of BL1811; PFAM_ID: AAA; PFAM_ID: Mg_chelatase YP_909426.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_909427.1 Orthologue of BL1813 YP_909428.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_909429.1 COG family: methyl-accepting chemotaxis protein; Orthologue of BL0003 YP_909430.1 Orthologue of BL0004 YP_909431.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL0005; PFAM_ID: response_reg; PFAM_ID: trans_reg_C YP_909432.1 COG family: sensory transduction histidine kinases; Orthologue of BL0006; PFAM_ID: HAMP; PFAM_ID: HATPase_c; PFAM_ID: signal YP_909433.1 COG family: cold shock proteins; Orthologue of BL0007; PFAM_ID:CSD YP_909434.1 Orthologue of BL0008 YP_909435.1 COG family: universal stress protein UspA andrelated nucleotide-binding proteins; Orthologue of BL0009; PFAM_ID: Usp YP_909436.1 Orthologue of Rv3596c_BL0010; ProbableclpC1_ ATP-dependent protease ATP-binding subunit (EC3.4.-.-) YP_909437.1 Orthologue of BL0016 YP_909438.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_909439.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_909440.1 Orthologue of lin0840 YP_909441.1 ATP-binding protein; Orthologue of SMU.805c YP_909442.1 COG family: ABC-type polar amino acidtransport system_ ATPase component; Orthologue of BL0021; PFAM_ID: ABC_tran YP_909443.1 COG family: ABC-type amino acid transportsystem_ periplasmic component; Orthologue of BL0022; PFAM_ID: SBP_bac_3 YP_909444.1 COG family: ABC-type amino acid transportsystem_ permease component; Orthologue of BL0023; PFAM_ID: BPD_transp YP_909445.1 COG family: ABC-type amino acid transportsystem_ permease component; Orthologue of BL0024; PFAM_ID: BPD_transp YP_909446.1 COG family: uncharacterized Bcr; Orthologue of BL0027 YP_909447.1 Orthologue of Tfu_0878_BL0028 YP_909448.1 COG family: uncharacterized ATPase related to thehelicase subunit of the holliday junction resolvase; Orthologue of BL0029; PFAM_ID: AAA YP_909449.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0037; PFAM_ID: sugar_tr YP_909450.1 COG family: proteasesubunit of ATP-dependent Clp proteases; Endopeptidase Clp1; Orthologue of BL0945; PFAM_ID:CLP_protease YP_909451.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_909452.1 binds and unfolds substrates as part of the ClpXP protease YP_909453.1 COG family: Na+_H+ antiporter; Orthologue of BL0942 YP_909454.1 COG family: SAM-dependent methyltransferases; Orthologue of BL0940; PFAM_ID: Methyltransf_3 YP_909455.1 COG family: succinate dehydrogenase_fumaratereductase Fe-S protein; Orthologue of BL0939; fumarate reductase YP_909456.1 COG family: succinate dehydrogenase_fumaratereductase_ flavoprotein subunits; Orthologue of BL0938; PFAM_ID: FAD_binding_2; PFAM_ID: succ_DH_flav_C YP_909457.1 COG family: predicted Rossmann-foldnucleotide-binding protein involved in DNA uptake; Orthologue of BL0937; PFAM_ID: SMF YP_909458.1 COG family: predicted ATPase with chaperoneactivity; Orthologue of BL0936; PFAM_ID: Mg_chelatase YP_909459.1 COG family: predicted endonuclease distantlyrelated to archaeal holliday junction resolvase; Orthologue of BL0935; PFAM_ID:UPF0102 YP_909460.1 COG family:pyridoxal_pyridoxine_pyridoxamine kinase; Orthologue of BL0934 YP_909461.1 COG family:O-acetylhomoserine sulfhydrylase; Homocysteine synthase; Oahsulfhydrylase; Orthologue of BL0933; PFAM_ID:Cys_Met_Meta_PP YP_909462.1 Orthologue of TK2102 YP_909463.1 Orthologue of TTE1589 YP_909464.1 Orthologue of Moth_0708 YP_909465.1 AsnC/Lrp; Orthologue of Tfu_1373 YP_909466.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL0932; PFAM_ID: ABC_tran YP_909467.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL0931; PFAM_ID: DUF214 YP_909468.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL0930; PFAM_ID: GerE; PFAM_ID: response_reg YP_909469.1 COG family: sensory transduction histidine kinases; Orthologue of BL0929; PFAM_ID: HATPase_c YP_909470.1 COG family:predicted hydrolases or acyltransferases (alpha_betahydrolase superfamily); Orthologue of BL0928; PFAM_ID: abhydrolase; Prolyl aminopeptidase YP_909471.1 COG family:pyrroline-5-carboxylate reductase; Orthologue of BL0927; PFAM_ID: P5CR YP_909472.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_909473.1 Orthologue of PAB3260 YP_909474.1 Orthologue of DR1219 YP_909475.1 Orthologue of BPSS0271 YP_909476.1 Orthologue of BL1511 YP_909477.1 COG family: permeases of the drug_metabolitetransporter (Dmt) superfamily; Orthologue of BL1444; PFAM_ID:DUF6 YP_909478.1 COG family: uncharacterized membrane protein; Membrane protein; Orthologue of BL1094 YP_909479.1 Orthologue of nfa47170 YP_909480.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_2381 YP_909481.1 COG family: predicted permeases; Orthologue of BL1190 YP_909482.1 AraC family; Orthologue of BT9727_2894 YP_909483.1 COG family: phosphoglyceratemutase_fructose-2_6- bisphosphatase; Orthologue of BL0911; PFAM_ID: PGAM YP_909484.1 COG family: xanthine_uracil permeases; Orthologue of BL0910; PFAM_ID: xan_ur_permease YP_909485.1 COG family: dehydrogenases with differentspecificities (related to short-chain alcoholdehydrogenases); Orthologue of BL0690; PFAM_ID: adh_short YP_909486.1 COG family: superfamily II DNA and RNA helicases; Identified by sequence similarity; Orthologue of BL0909; PFAM_ID: DEAD; PFAM_ID: helicase_C YP_909487.1 COG family: predicted permease; Orthologue of BL0063 YP_909488.1 COG family: ABC-type multidrug_protein_lipidtransport system_ ATPase component; Orthologue of BL0064; PFAM_ID: ABC_tran YP_909489.1 Identified by sequence similarity; Orthologue of Lxx14510 YP_909490.1 COG family: uncharacterized Bcr; Identified by sequence similarity; Orthologue of BL0570 YP_909491.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_909492.1 COG family:6-phosphogluconolactonase_glucosamine-6- phosphateisomerase_deaminase; Orthologue of BL0443 YP_909493.1 COG family: uncharacterized Bcr_ stimulatesglucose-6-P dehydrogenase activity; Orthologue of BL0441 YP_909494.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_909495.1 Identified by match to protein family HMM PF01554 and match to protein family HMM TIGR00797; Orthologue of TDE1055 YP_909496.1 Orthologue of Atu1295; Putative ORF located using Glimmer YP_909497.1 Orthologue of SSP0322 YP_909498.1 Orthologue of BT1398_BF2133 YP_909499.1 Orthologue of lp_2889 YP_909500.1 COG family: putative NADPH-quinone reductase(modulator of drug activity B); Orthologue of BL1749; PFAM_ID: NADHdh_2 YP_909501.1 COG family: predicted branched-chain amino acidpermease (azaleucine resistance); Orthologue of BL1669 YP_909502.1 COG family: predicted branched-chain aminoacid permeases (azaleucine resistance); Orthologue of BL1668 YP_909503.1 COG family: beta-glucosidase-related glycosidases; Orthologue of BL1031; PFAM_ID: Glyco_hydro_3 YP_909504.1 Orthologue of Tfu_0541_BL1029 YP_909505.1 COG family: sortase and related acyltransferases; Orthologue of BL1028; PFAM_ID: Acetyltransf YP_909506.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_909507.1 Orthologue of Rv1020_BL1025; Probable mfd(alternate gene name: trcF)_ transcription-repair couplingfactor similar to many e.g.MFD_ECOLI|P30958 transcription-repair coupling factor from Escherichia coli YP_909508.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_909509.1 COG family: septum formation initiator; Orthologue of BL1021 YP_909510.1 COG family: uncharacterized Acr; Orthologue of BL1020 YP_909511.1 COG family: exopolyphosphatase; Orthologue of BL1019; PFAM_ID: Ppx-GppA YP_909512.1 Cd efflux system component [Wolbachia endosymbiont strain TRS of Brugia malayi] YP_909513.1 COG family: L-serinedeaminase; L-serine deaminase; Orthologue of BL1017 YP_909514.1 COG family: FkbP-type peptidyl-prolylcis-trans isomerases 1; Orthologue of BL1016; PFAM_ID: FKBP YP_909515.1 COG family:transcription elongation factor; Orthologue of BL1015; PFAM_ID: GreA_GreB YP_909516.1 COG family: predicted membrane proteins_ hemolysinIII homologs; Orthologue of BL1014; PFAM_ID: UPF0073 YP_909517.1 COG family: sensory transduction histidine kinases; Orthologue of BL1012; PFAM_ID: HATPase_c YP_909518.1 Orthologue of BL1011 YP_909519.1 COG family: DNA segregation ATPase FtsK_SpoIIIE andrelated proteins; Orthologue of BL1010; PFAM_ID: FtsK_SpoIIIE YP_909520.1 COG family: transcriptional regulator; Orthologue of BL1009 YP_909521.1 Orthologue of SCO4755; Possible transcriptional regulator YP_909522.1 Orthologue of BL1008 YP_909523.1 COG family: predicted glycosyltransferases; Orthologue of BL1007 YP_909524.1 Orthologue of BL1006 YP_909525.1 Orthologue of BL1005 YP_909526.1 COG family: predicted hydrolases of the Hadsuperfamily; Orthologue of BL1004 YP_909527.1 COG family: predicted amidophosphoribosyltransferases; Orthologue of BL1003; PFAM_ID: Pribosyltran YP_909528.1 COG family: sensory transduction histidine kinases; Orthologue of BL1001; PFAM_ID: HAMP; PFAM_ID: HATPase_c; PFAM_ID: signal YP_909529.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL1000; PFAM_ID: response_reg; PFAM_ID: trans_reg_C YP_909530.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_909531.1 COG family: transcriptional regulators_ similar toM. xanthus card; Orthologue of BL0998; PFAM_ID: TF_CarD YP_909532.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_909533.1 COG family: ABC-type Mn2+_Zn2+ transport systems_permease components; Orthologue of BL0996; PFAM_ID: ABC-3 YP_909534.1 COG family: ABC-typecobalamin_Fe3+-siderophores transport systems_ ATPasecomponents; Orthologue of BL0995; PFAM_ID: ABC_tran YP_909535.1 COG family: ABC-type Mn_Zn transport system_periplasmic Mn_Zn-binding (lipo)protein (surface adhesina); Orthologue of BL0994; PFAM_ID: Lipoprotein_4 YP_909536.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_909537.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_909538.1 COG family: dephospho-CoA kinase; Orthologue of BL0991; PFAM_ID: CoaE YP_909539.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_909540.1 COG family: membrane protein TerC possiblyinvolved in tellurium resistance; Identified by sequence similarity; Orthologue of BL0989 YP_909541.1 COG family: pyruvate kinase; Orthologue of BL0988; PFAM_ID: PK YP_909542.1 COG family: CheY-like receiver domains; Orthologue of BL0986; PFAM_ID:response_reg YP_909543.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_909544.1 COG family: uncharacterized Acr; Orthologue of BL0984; PFAM_ID: DUF34 YP_909545.1 COG family: NTP pyrophosphohydrolases includingoxidative damage repair enzymes; Orthologue of BL0983; PFAM_ID: NUDIX YP_909546.1 Orthologue of Rv1564c_BL0982; Probable treX(previously called glgX)_ Maltooligosyltrehalose synthase.Strong similarity to D83245|g1890053 treX_ glycogendebranching enzyme (glgX) from Sulfolobus acidocaldarius YP_909547.1 Orthologue of BL0971 YP_909548.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_909549.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_909550.1 Orthologue of Synpcc7942_2080 YP_909551.1 COG family:phosphotransacetylase; Orthologue of BL0968; PFAM_ID: PTA_PTB; Phosphotransacetylase YP_909552.1 COG family: acetate kinase; Orthologue of BL0969; PFAM_ID: Acetate_kinase YP_909553.1 COG family: predicted acyltransferases; Orthologue of BL0962 YP_909554.1 COG family: xanthine_uracil permeases; Orthologue of BL0892; PFAM_ID: xan_ur_permease YP_909555.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_909556.1 Orthologue of Rv0949_BL0890; ProbableuvrD1_ ATP dependent DNA helicase II (EC 3.6.1.-) YP_909557.1 Orthologue of BL0889 YP_909558.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL0888; PFAM_ID: DUF214 YP_909559.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL0887; PFAM_ID: ABC_tran YP_909560.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_909561.1 COG family: phosphoglyceratemutase_fructose-2_6- bisphosphatase; Orthologue of BL0884; PFAM_ID: PGAM YP_909562.1 Identified by sequence similarity; Orthologue of Lxx10890 YP_909563.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_909564.1 COG family: predicted endonuclease involved inrecombination (possible holliday junction resolvase inmycoplasmas and B. subtilis); Orthologue of BL0881 YP_909565.1 COG family: predicted periplasmic solute-bindingprotein; Orthologue of BL0880; PFAM_ID: DUF175 YP_909566.1 Orthologue of XOO3073 YP_909567.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_909568.1 catalyzes the formation of shikimate 3-phosphate from shikimate and the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_909569.1 catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis YP_909570.1 Orthologue of SAV5981 YP_909571.1 Orthologue of BCZK2463 YP_909572.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_909573.1 Orthologue of Tfu_1987_BL0872 YP_909574.1 COG family: predicted membrane components of anuncharacterized iron-regulated ABC-type transporter SufB; Orthologue of BL0871_Tfu_1987; PFAM_ID: UPF0051 YP_909575.1 COG family: iron-regulated ABC transporter ATPasesubunit SufC; Identified by sequence similarity; Orthologue of BL0870; PFAM_ID: ABC_tran YP_909576.1 COG family: iron-regulated ABC transporter ATPasesubunit SufC; Orthologue of BL0869; PFAM_ID: ABC_tran YP_909577.1 COG family: NifU homologs involved in Fe-S clusterformation; Orthologue of BL0868; PFAM_ID: NifU_N YP_909578.1 COG family: putative aromatic ring hydroxylatingenzyme; Orthologue of BL0867; PFAM_ID: DUF59 YP_909579.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_909580.1 COG family: rRNA methylases; Orthologue of BL0865; PFAM_ID:SpoU_methylase YP_909581.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_909582.1 COG family: diadenosine tetraphosphate (Ap4A)hydrolase and other Hit family hydrolases; Orthologue of BL0863; PFAM_ID: HIT YP_909583.1 COG family: phosphate starvation-inducible proteinPhoH_ predicted ATPase; Orthologue of BL0862; PFAM_ID: PhoH YP_909584.1 COG family: predicted metal-dependent hydrolase; Orthologue of BL0861; PFAM_ID: UPF0054 YP_909585.1 COG family: uncharacterized CBS domain-containingproteins; Orthologue of BL0860; PFAM_ID: CBS YP_909586.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_909587.1 COG family: long-chain acyl-CoA synthetases(AMP-forming); Orthologue of BL0858; PFAM_ID: AMP-binding YP_909588.1 COG family: NAD_NADP transhydrogenase alphasubunit; Orthologue of BL0857; PFAM_ID: AlaDh_PNT; Pyridine nucleotide transhydrogenase subunit alpha1 YP_909589.1 COG family: NAD_NADP transhydrogenase beta subunit; Orthologue of BL0856; PFAM_ID: PNTB; Pyridine nucleotide transhydrogenase subunit beta YP_909590.1 Orthologue of BP2948; Similar to Escherichia coli riboflavin biosynthesis protein (diamino hydroxyphospho ribosylaminopyrimidinedeaminase) YP_909591.1 Orthologue of BT1387 YP_909592.1 Orthologue of BSU05460; Similar to multidrug-efflux transporter regulator YP_909594.1 Orthologue of BF2138; Similar to Mycoplasma penetrans hypothetical protein mype1860 YP_909595.1 Orthologue of SCO7639; Probable marR-family regulatory protein YP_909596.1 EmrB/QacA family protein; Identified by match to protein family HMM PF07690; Orthologue of BTH_II2230 YP_909597.1 COG family: integral membrane protein possiblyinvolved in chromosome condensation; Orthologue of BL1091; PFAM_ID: CRCB YP_909598.1 COG family: integral membrane protein possiblyinvolved in chromosome condensation; Orthologue of BL1092; PFAM_ID: CRCB YP_909599.1 Orthologue of BL0695 YP_909600.1 COG family: ABC-type cobalt transport system_permease component CbiQ and related transporters; Orthologue of BL0694; PFAM_ID:CbiQ YP_909601.1 COG family: ABC-type cobalt transport system_ATPase component; Orthologue of BL0693; PFAM_ID: ABC_tran; PFAM_ID: PRK YP_909602.1 Orthologue of BL0692 YP_909603.1 Orthologue of BL1083_LBA1002; UvrA YP_909604.1 COG family: hydrolases of the alpha_betasuperfamily; Orthologue of BL0855 YP_909605.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_909606.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_909607.1 COG family: predicted membrane protein; Orthologue of BL0850 YP_909608.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_909609.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_909610.1 COGfamily: coproporphyrinogen III oxidase and related FeSoxidoreductases; Orthologue of BL0847; PFAM_ID: Coprogen_an_ox; coproporphyrinogenase YP_909611.1 Orthologue of Rv3859c_BL0834; ProbablegltB_ ferredoxin-dependent glutamate synthase largesubunit (EC 1.4.1.13) YP_909612.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_909613.1 Orthologue of BL0827 YP_909614.1 COG family: predicted glycosyltransferases; Orthologue of BL0826; PFAM_ID: Glycos_transf_1 YP_909615.1 COG family: ABC-type molybdenum transport system_ATPase component_photorepair protein PhrA; Orthologue of BL0825; PFAM_ID:ABC_tran YP_909616.1 COG family: predicted SAM-dependentmethyltransferase involved in tRNA-met maturation; Orthologue of BL0800 YP_909617.1 COG family: phosphohistidine phosphatase SixA; Orthologue of BL0799; PFAM_ID: PGAM YP_909618.1 Orthologue of BF1907; Similar to Mycoplasma penetrans hypothetical protein mype1860 YP_909619.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_909620.1 COG family: 5_10- methylenetetrahydrofolatereductase; Orthologue of BL0797; PFAM_ID: MTHFR YP_909621.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_909622.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_909623.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_909624.1 COG family: dihydroorotase; Orthologue of BL0792; PFAM_ID:Dihydroorotase YP_909625.1 COG family:orotidine-5'-phosphate decarboxylase; OMP decarboxylase; Orthologue of BL0791 YP_909626.1 COG family: 2-polyprenylphenolhydroxylase and related flavodoxin oxidoreductases; Orthologue of BL0790; PFAM_ID: FAD_binding_6 YP_909627.1 COG family: dihydroorotate dehydrogenase; Orthologue of BL0789; PFAM_ID: DHOdehase YP_909628.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_909629.1 COG family: transcriptional regulator; Orthologue of BL0786_C-terminal fragment; PFAM_ID: HTH_1 YP_909630.1 COG family: transcriptional regulator; Orthologue of BL0786_N-terminal fragment; PFAM_ID: HTH_1 YP_909631.1 COG family: predicted hydrolases of the Hadsuperfamily; Orthologue of BL0785; PFAM_ID: Hydrolase YP_909632.1 Identified by match to protein family HMM PF00657; Orthologue of SRU_2203 YP_909633.1 Identified by match to protein family HMM PF02687;match to protein family HMM TIGR01612; Orthologue of LMOf2365_1233; Permease protein YP_909634.1 COG family: predicted sugar kinase; Orthologue of BL0784; PFAM_ID:UPF0031 YP_909635.1 ATP-binding protein; Orthologue of SP1653 YP_909636.1 COG family: membrane proteins related tometalloendopeptidases; Orthologue of BL1497; PFAM_ID: Peptidase_M37 YP_909637.1 COG family: long-chain acyl-CoA synthetases(AMP-forming); Orthologue of BL1748; PFAM_ID: AMP-binding YP_909638.1 COG family: periplasmic sugar-binding proteins; Orthologue of BL1498 YP_909639.1 NADP; Converts isocitrate to alpha ketoglutarate YP_909640.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_909641.1 Identified by sequence similarity; Orthologue of Atu4275 YP_909642.1 COG family: long-chain acyl-CoA synthetases(AMP-forming); Orthologue of BL1501; PFAM_ID: AMP-binding YP_909643.1 COG family:N-formylmethionyl-tRNA deformylase; Orthologue of BL1502; PFAM_ID:Pep_deformylase; formylmethionine deformylase YP_909644.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_909645.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_909646.1 Catalyzes the phosphorylation of UMP to UDP YP_909647.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_909648.1 CDP-diglyceride synthetase; COGfamily: CDP-diglyceride synthetase; Orthologue of BL1507; PFAM_ID:Cytidylyltrans YP_909649.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_909650.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_909651.1 PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers YP_909652.1 Catalyzes the formation of anthranilate andglutamate from chorismate and glutamine; Orthologue of BL0687 YP_909653.1 catalyzes ring closure to form indole-3-glycerol phosphate; catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_909654.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_909655.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_909656.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_909657.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis YP_909658.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_909659.1 COG family: phosphatidylglycerophosphatesynthase; Orthologue of BL0750; PFAM_ID: CDP-OH_P_transf; Phosphatidylglycerophosphate synthase YP_909660.1 Orthologue of BL0749 YP_909661.1 Orthologue of BL0748a YP_909662.1 Orthologue of BL0748 YP_909663.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_909664.1 Orthologue of PPA1078 YP_909665.1 COG family: uncharacterized Acr; Orthologue of BL0726; PFAM_ID: DUF28 YP_909666.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_909667.1 COG family: holliday junction resolvasomeDNA-binding subunit; Orthologue of BL0728; PFAM_ID: RuvA; PFAM_ID: RuvA_II YP_909668.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_909669.1 COG family: preprotein translocase subunit YajC; Orthologue of BL0730; PFAM_ID: DUF219 YP_909670.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_909671.1 COG family: succinyl-CoA synthetasebeta subunit; Orthologue of BL0732; PFAM_ID: ATP-grasp; PFAM_ID: ligase-CoA YP_909672.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_909673.1 Orthologue of BL0734 YP_909674.2 involved in de novo purine biosynthesis YP_909675.1 COG family: glycerol uptake facilitator and relatedpermeases (major intrinsic protein family); Orthologue of BL0736; PFAM_ID: MIP YP_909676.1 Orthologue of BP2096 YP_909677.1 Orthologue of SAV1 YP_909678.1 CMK catalyzes the formation of (d)CDP from ATP and (d)CMP; the function of the GTP-binding domain EngA appears to be in synchronizing cellular events by interacting with multiple cellular targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide-binding affinities in the two binding domains YP_909679.1 Orthologue of BL0739; UDP-glucose pyrophosphorylase YP_909680.1 Orthologue of BL0741 YP_909681.1 Identified by sequence similarity; Orthologue of Lxx08340_BL0742 YP_909682.1 Orthologue of BL0743 YP_909683.1 COG family: predicted phosphatases; Orthologue of BL0744; PFAM_ID:Hydrolase YP_909684.1 Functions in anaerobic transport ofC4-dicarboxylate compounds such as fumarate; Orthologue of MTH934_ECs5105 YP_909685.1 COG family: predicted transcriptional regulators; Orthologue of BL0746 YP_909686.1 COG family: FHA-domain-containing proteins; Orthologue of BL0747; PFAM_ID: FHA YP_909687.1 Orthologue of BL0722 YP_909688.1 phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_909689.1 COG family: uncharacterized Bcr; Orthologue of BL0720 YP_909690.1 COG family: molecular chaperones (containC-terminal Zn finger domain); Orthologue of BL0719; PFAM_ID: DnaJ; PFAM_ID: DnaJ_C; PFAM_ID:DnaJ_CXXCXGXG YP_909691.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_909692.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_909693.1 catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate YP_909694.1 in Corynebacterium glutamicum the aminotransferase can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; this protein contains a helix-turn-helix domain at the N-terminus YP_909695.1 COG family: predicted hydrolases of the Hadsuperfamily; Orthologue of BL0711 YP_909696.1 Orthologue of BL0709 YP_909697.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_909698.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_909699.1 COG family: uncharacterized Bcr; Orthologue of BL0706; PFAM_ID: DUF199 YP_909700.1 COG family: predicted P-loop-containing kinase; Orthologue of BL0705 YP_909701.1 COG family: shikimate 5-dehydrogenase; Orthologue of BL0704; PFAM_ID: Shikimate_DH YP_909702.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_909703.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_909704.1 Orthologue of BL0700 YP_909705.1 Orthologue of BL0699 YP_909706.1 Orthologue of BL0698 YP_909707.1 Orthologue of BL0697 YP_909708.1 Orthologue of FTT0478c; Similar to RECJ_HAEIN (P45112)single-stranded-DNA-specific exonuclease from Haemophilusinfluenzae YP_909709.1 Orthologue of PSHAa2974 YP_909710.1 Orthologue of PPA1479 YP_909711.1 Orthologue of BL0760 YP_909712.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_2065 YP_909713.1 COG0488_ Uup_ ATPase components of ABC transporterswith duplicated ATPase domains.; Fused ATPase subunits; Orthologue of RSP_2895 YP_909714.1 Orthologue of Tfu_1880_BL0689 YP_909715.1 Identified by sequence similarity; Orthologue of Lxx01710 YP_909716.1 Orthologue of CPj0143 YP_909717.1 Orthologue of LBA0464 YP_909718.1 MerR; Orthologue of Tfu_1384 YP_909719.1 COG family: penicillin V acylase and relatedamidases; Conjugated bile acid hydrolase; Orthologue of BL0796; PFAM_ID: CBAH YP_909720.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_909721.1 COG family: acetyltransferases; Orthologue of BL1456; PFAM_ID:Acetyltransf YP_909722.1 COG family: inactive homologs of metal-dependentproteases_ putative molecular chaperones; Orthologue of BL1455 YP_909723.1 Orthologue of SAV4969; PF02367: Uncharacterised P-loop hydrolase UPF0079 YP_909724.1 COG family: DNA polymerase III delta subunit; Orthologue of BL1454 YP_909725.1 COG family: predicted multitransmembrane_metal-binding protein; Orthologue of BL1452 YP_909726.1 COG family: DNA uptake protein and relatedDNA-binding proteins; Orthologue of BL1451; PFAM_ID: HHH YP_909727.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_909728.1 COG family: ABC-type amino acid transport system_periplasmic component; Orthologue of BL1449; PFAM_ID: SBP_bac_3 YP_909729.1 COG family: Mg2+ and Co2+ transporters; Orthologue of BL1448; PFAM_ID: CorA YP_909730.1 COG family: phosphoglyceratemutase_fructose-2_6- bisphosphatase; Orthologue of BL1447; PFAM_ID: PGAM YP_909731.1 Orthologue of BL1443 YP_909732.1 COG family: phosphoglyceratemutase_fructose-2_6- bisphosphatase; Orthologue of BL0966; PFAM_ID: PGAM YP_909733.1 COG family: uncharacterized Acr (homolog of plantiojap proteins); Orthologue of BL0965; PFAM_ID: DUF143 YP_909734.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_909735.1 Orthologue of HH0341; Similar to Campylobacter jejuni CJ1254 YP_909736.1 COG family: predicted oxidoreductases (related toaryl-alcohol dehydrogenases); Orthologue of BL0290; PFAM_ID: aldo_ket_red YP_909737.1 Orthologue of spr0628; Probable transcriptional regulator YP_909738.1 Identified by match to protein family HMM PF00571; Orthologue of DVU0445 YP_909739.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_A1396 YP_909740.1 Identified by Glimmer2; putative; Orthologue of BCE0996 YP_909741.1 Orthologue of CE1244 YP_909742.1 Orthologue of CE1245 YP_909743.1 Orthologue of CPE1289 YP_909744.1 Orthologue of BB0913; Similar to Salmonella typhimurium type III restriction-modification system stylti enzyme res orstm0358 SWALL:T3RE_SALTY (SWALL:P40815) YP_909745.1 Orthologue of TWT151 YP_909746.1 Orthologue of y0750 YP_909747.1 Orthologue of DIP2252; Similar to Bacillus subtilis hypothetical 72.2 kDa protein YrhL YP_909748.1 COG family: histone acetyltransferase Hpa2 andrelated acetyltransferases; Orthologue of BL0561; PFAM_ID: Acetyltransf YP_909749.1 Hypothetical protein; Orthologue of bll1128 YP_909750.1 Orthologue of PMM1692 YP_909751.1 Orthologue of pNG3054 YP_909752.1 Orthologue of BTH_I1000 YP_909753.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL0269; PFAM_ID: DUF214 YP_909754.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL0268; PFAM_ID: DUF214 YP_909755.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ ATPase components; Orthologue of BL0267; PFAM_ID: ABC_tran YP_909756.1 Orthologue of BURPS1710b_A0691 YP_909757.1 Orthologue of BCE4987 YP_909758.1 Orthologue of GK2134 YP_909759.1 Orthologue of BSU18690 N-terminal fragment YP_909761.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_909762.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_909763.1 Orthologue of BL1033 YP_909764.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_909765.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_909766.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_909767.1 Orthologue of lp_0893 YP_909768.1 COG family: predicted transcriptional regulators; Orthologue of BL1041a; PFAM_ID: gntR YP_909769.1 COG family: predicted phosphatase_phosphohexomutase; Orthologue of BL1042; PFAM_ID: Hydrolase YP_909770.1 COG family: ATPasesinvolved in DNA repair; Orthologue of BL1043; Recombination protein N YP_909771.1 catalyzes the phosphorylation of NAD to NADP YP_909772.1 COG family: Trk-type K+ transport systems_ membranecomponents; Orthologue of BL1045; PFAM_ID: TrkH YP_909773.1 COG family: K+ transport systems_ NAD-bindingcomponent; Orthologue of BL1046; PFAM_ID: KTN; PFAM_ID: TrkA YP_909774.1 COG family: predicted rRNA methylases; Orthologue of BL1048; PFAM_ID: FtsJ; PFAM_ID: S4 YP_909775.1 COG family: predicted sugar phosphatases of the Hadsuperfamily; Orthologue of BL1049; PFAM_ID: Hydrolase YP_909776.1 Orthologue of BL1050 YP_909777.1 COG family:tyrosyl-tRNA synthetase; Orthologue of BL1051; PFAM_ID: tRNA-synt_1b; PFAM_ID:S4; Tyrosine-tRNA ligase YP_909778.1 Couples the complete acetyl-CoA oxidation toaromatic ring reduction by the use of the low-potentialelectron shuttle ferredoxin; Orthologue of DP2321 YP_909779.1 Orthologue of lin2818 YP_909780.1 COG family: predicted HD superfamily hydrolase; Orthologue of BL1053; PFAM_ID: HD YP_909781.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_909782.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_909783.1 COG family: arginine repressor; Orthologue of BL1059; PFAM_ID: Arg_repressor_C; PFAM_ID:Arg_repressor YP_909784.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation YP_909785.1 catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine YP_909786.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_909787.1 bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate YP_909788.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_909789.1 Orthologue of BL1065 YP_909790.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_909791.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_909792.1 COG family: rRNA methylases; Orthologue of BL1068; PFAM_ID:SpoU_methylase YP_909793.1 Orthologue of lmo1506 YP_909794.1 Identified by match to protein family HMM PF00005; Orthologue of BCE2757 YP_909795.1 COG family: xanthine_uracil permeases; Orthologue of BL0515; PFAM_ID:xan_ur_permease YP_909796.1 Acyl-CoA reductase-like protein; Orthologue of BL0514 YP_909797.1 Orthologue of BL0513 YP_909798.1 3-ketoacyl-acyl carrier protein reductase; COGfamily: dehydrogenases with different specificities(related to short-chain alcohol dehydrogenases); Orthologue of BL0512; PFAM_ID:adh_short YP_909799.1 Orthologue of gbs1997; Similar to unknown protein YP_909800.1 COG family: predicted permeases; Orthologue of BL0281 YP_909801.1 Orthologue of SCO4446 YP_909802.1 Orthologue of Moth_1796 YP_909803.1 Orthologue of Rv2022c YP_909804.1 Identified by match to protein family HMM PF03372; Orthologue of BURPS1710b_A0408 YP_909805.1 Orthologue of SCP1.290c YP_909806.1 Orthologue of jk0702_BL1076 YP_909807.1 Orthologue of BL1075 YP_909808.1 COG family: dihydrolipoamidedehydrogenase_glutathio ne oxidoreductase and relatedenzymes; Orthologue of BL1074; PFAM_ID: pyr_redox YP_909809.1 Orthologue of BL1073 YP_909810.1 COG family: acetylornithinedeacetylase_succinyl- diaminopimelate desuccinylase andrelated deacylases; Orthologue of BL1072; PFAM_ID: Peptidase_M20 YP_909811.1 COG family: ABC-type cobalt transport system_permease component CbiQ and related transporters; Orthologue of BL1069; PFAM_ID:CbiQ YP_909812.1 COG family: ABC-type cobalt transport system_ATPase component; Orthologue of BL1070; PFAM_ID: ABC_tran YP_909813.1 Orthologue of BL1071 YP_909814.1 COG family: ATPases involved in chromosomepartitioning; Orthologue of BL0053; PFAM_ID: DUF59; PFAM_ID: fer4_NifH YP_909815.1 Orthologue of BL0052 YP_909816.1 Orthologue of BL0051 YP_909817.1 Orthologue of BL0050 YP_909818.1 COG family: ABC-type cobalt transport system_ATPase component; Orthologue of BL0049; PFAM_ID: ABC_tran YP_909819.1 COG family: PLP-dependent aminotransferases; Orthologue of BL0048; PFAM_ID: aminotran_1_2 YP_909820.1 COG family: transcriptional regulators; Orthologue of BL0047; PFAM_ID: ROK YP_909821.1 COG family: predicted glycosyltransferases; Orthologue of BL0045; PFAM_ID: Glycos_transf_2 YP_909822.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_2627 YP_909823.1 COG family: predicted RNA-binding proteincontaining KH domain_ possibly ribosomal protein; Orthologue of BL0042; PFAM_ID:UPF0044 YP_909824.1 COG family: ABC-type cobalt transport system_permease component CbiQ and related transporters; Orthologue of BL0043; PFAM_ID: CbiQ; PFAM_ID:ABC_tran YP_909825.1 COG family: uncharacterized membrane protein; Orthologue of BL0044 YP_909826.1 COG family: superfamily II DNA_RNA helicases_ Snf2family; Orthologue of BL1736; PFAM_ID: SNF2_N; PFAM_ID: helicase_C YP_909827.1 COG family: aminopeptidase C; Orthologue of BL0173; PFAM_ID:Pept_C1-like YP_909828.1 Orthologue of CE2653 YP_909829.1 COG family: Kef-type K+ transport systems_predicted NAD-binding component; Orthologue of BL0664; PFAM_ID: ion_trans YP_909830.1 COG family: phosphoglycerate dehydrogenase andrelated dehydrogenases; Orthologue of BL0038; PFAM_ID: 2-Hacid_DH_C YP_909831.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_909832.1 Orthologue of BL1548 YP_909833.1 COG family: transcriptional regulators; Orthologue of BL0142; PFAM_ID: Peripla_BP_like; PFAM_ID:lacI YP_909834.1 COG family: glycosidases; Orthologue of BL0529; PFAM_ID:alpha-amylase YP_909835.1 COG family: sugar-binding periplasmicproteins_domains; Orthologue of BL0141; PFAM_ID: SBP_bacterial_1 YP_909836.1 Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine andfree tRNA(Tyr). Could be a defense mechanism against aharmful effect of D-tyrosine; Orthologue of BL1326 YP_909837.1 Orthologue of LSA1255 YP_909838.1 Orthologue of Ava_0847 YP_909839.1 Orthologue of Cag_1061 YP_909840.1 Identified by match to protein family HMM; Orthologue of CC3080 YP_909841.1 Orthologue of XF1862_RPA0941; Similar to GI|1934987 YP_909842.1 Orthologue of SSO3095 YP_909843.1 COG family: dihydroxyaciddehydratase_phosphoglucona te dehydratase; Orthologue of BL0923 YP_909844.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL1801 YP_909845.1 Orthologue of Nmul_D2818_BPP3752; UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenolN- acetylglucosamine transferase; involved in cell wallformation; inner membrane-associated; last step ofpeptidoglycan synthesis YP_909846.1 COG family: histone acetyltransferase Hpa2 andrelated acetyltransferases; Orthologue of BL1401; PFAM_ID: Acetyltransf YP_909847.1 Orthologue of BCZK1488 YP_909848.1 3'-5' exonuclease of DNA polymerase III; Orthologue of SAV6439 YP_909849.1 Converts homocysteine and S-adenosyl-methionine tomethionine and S-adenosyl-homocysteine orS-methyl-methionine and homocysteine to two methionines; Orthologue of lp_1298 YP_909850.1 COG family: amino acid transporters; Orthologue of BL0778; PFAM_ID:aa_permeases YP_909851.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_909852.1 COG family: ribonuclease D; Orthologue of BL0948; PFAM_ID:3_5_exonuclease YP_909853.1 Orthologue of BL0949 YP_909854.1 COG family:pyruvate-formate lyase-activating enzyme; Orthologue of BL0950; PFAM_ID:Radical_activat; Pfl-activating enzyme YP_909855.1 Orthologue of BL0951_HI0180 YP_909856.1 Orthologue of BL0952 YP_909857.1 COGfamily: NAD synthase; Orthologue of BL0953; PFAM_ID: CN_hydrolase; PFAM_ID:NAD_synthase YP_909858.1 COG family: metal- dependentamidase_aminoacylase_carboxypeptidase; Orthologue of BL0954; PFAM_ID:Peptidase_M20 YP_909859.1 COG family: predicted hydrolases of the Hadsuperfamily; Orthologue of BL0958; PFAM_ID: Hydrolase YP_909860.1 Orthologue of PA5505 YP_909861.1 ATP-binding protein; Identified by match to protein family HMM PF00005; Orthologue of BTH_I1650 YP_909862.1 Orthologue of VV0891 YP_909863.1 Orthologue of Pcar_2682 YP_909864.1 COG family: peptidyl-prolyl cis-trans isomerase(rotamase) - cyclophilin family; Orthologue of BL1442; PFAM_ID: pro_isomerase YP_909865.1 Orthologue of Rv2583c_BL1439; Probable relA_GTP pyrophosphokinase (EC 2.7.6.5) YP_909866.1 COG family:dUTPase; Orthologue of BL1438; PFAM_ID: dUTPase; dUTP pyrophosphatase YP_909867.1 Orthologue of BL1437 YP_909868.1 Orthologue of BL1436 YP_909869.1 COG family: uncharacterized proteins of the APsuperfamily; Orthologue of BL1435 YP_909870.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_909871.1 Orthologue of b1653_BL1432 YP_909872.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL1430 YP_909873.1 COG family: DNA gyrase (topoisomerase II) Bsubunit; Orthologue of BL1429; PFAM_ID: DNA_gyraseB_C; PFAM_ID: DNA_topoisoII; PFAM_ID: HATPase_c YP_909874.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released YP_909875.1 Orthologue of BL1427 YP_909876.1 COG family: geranylgeranyl pyrophosphatesynthase; Orthologue of BL1426; PFAM_ID: polyprenyl_synt; includes: farnesylpyrophosphate synthetase (Fpp synthetase)(dimethylallyltransferase); geranyltranstransferase YP_909877.1 COG family: serine_threonine proteinkinases; Orthologue of BL1425; PFAM_ID: pkinase YP_909878.1 COG family: 1-acyl-sn-glycerol-3- phosphateacyltransferase; Orthologue of BL1424; PFAM_ID: Acyltransferase YP_909879.1 Orthologue of BL1423 YP_909880.1 Orthologue of HI1721 YP_909881.1 Orthologue of b3558 YP_909882.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_909883.2 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_909884.1 COG family: ribosome-associated protein y (Psrp-1); Orthologue of BL1418; PFAM_ID: Ribosomal_S30 YP_909885.1 Orthologue of BL1417 YP_909886.1 COG family: uncharacterized Bcr; Orthologue of BL1416; PFAM_ID: RecX YP_909887.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_909888.1 Orthologue of SCO0160; Spossible DNA-binding protein_ len: 195aa_ similarity to Mycobacterium tuberculosis TR:O53625(EMBL; AL021428) hypothetical 16.6 KD protein YP_909889.1 COG family: predicted transcriptional regulators; Orthologue of BL1414; PFAM_ID: HTH_3 YP_909890.1 COG family: uncharacterized protein (competence-and mitomycin-induced); Orthologue of BL1413; PFAM_ID: CinA YP_909891.1 COG family: phosphatidylglycerophosphatesynthase; Orthologue of BL1412; PFAM_ID: CDP-OH_P_transf; Phosphatidylglycerophosphate synthase YP_909892.1 Orthologue of Tfu_0793_BL1411 YP_909893.1 Orthologue of BF0839 YP_909894.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_909895.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_909896.1 COG family: uncharacterized Bcr; Orthologue of BL1407 YP_909897.1 COG family: permeases of the drug_metabolitetransporter (Dmt) superfamily; Orthologue of BL1406; PFAM_ID:DUF6 YP_909898.1 COG family: integral membrane protein_ interactswith FtsH; Orthologue of BL1405; PFAM_ID: UPF0005 YP_909899.1 Orthologue of BL1404 YP_909900.1 COG family: sensory transduction histidine kinases; Orthologue of BL1403 YP_909901.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL1402; PFAM_ID: GerE; PFAM_ID: response_reg YP_909902.1 COG family: uncharacterized Acr; Orthologue of BL1400 YP_909903.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL0903; PFAM_ID: GerE; PFAM_ID: response_reg YP_909904.1 COG family: sensory transduction histidine kinases; Orthologue of BL0902 YP_909905.1 COG family: ABC-type multidrug transport system_ATPase component; Orthologue of BL0901; PFAM_ID: ABC_tran YP_909906.1 COG family: ABC-type multidrug transport system_permease component; Orthologue of BL0900 YP_909907.1 COG family: ABC-type multidrug transport system_permease component; Orthologue of BL0899 YP_909908.1 COG family: lactoylglutathione lyase and relatedlyases; Orthologue of BL0896; PFAM_ID: Glyoxalase YP_909909.1 Orthologue of CPE0864 YP_909910.1 Orthologue of lp_3093 YP_909911.1 Orthologue of BSU05150; Similar to transcriptional regulator (AraC_XylSfamily) YP_909912.1 Orthologue of jk1779 YP_909913.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_0926 YP_909914.1 COG family: transcriptional regulators; Orthologue of BL0107; PFAM_ID: Peripla_BP_like; PFAM_ID:lacI YP_909915.1 Catalyzes the conversion of citrate to isocitrate YP_909916.1 COG family: cation transport ATPases; Orthologue of BL1396; PFAM_ID: E1-E2_ATPase; PFAM_ID: Hydrolase YP_909917.1 Orthologue of BL1395 YP_909918.1 COG family: SAM-dependent methyltransferasesrelated to tRNA (uracil-5-)-methyltransferase; Orthologue of BL1394; PFAM_ID:TRAM YP_909919.1 Orthologue of BL1393 YP_909920.1 Orthologue of BL1392 YP_909921.1 COG family: exonuclease III; Orthologue of BL1391; PFAM_ID:AP_endonucleas1 YP_909922.1 COG family: ATPase components of various ABC-typetransport systems_ contain duplicated ATPase; Orthologue of BL1390; PFAM_ID:ABC_tran YP_909923.1 COG family: ABC-typedipeptide_oligopeptide_nickel transport systems_ permeasecomponents; Orthologue of BL1389; PFAM_ID: BPD_transp YP_909924.1 COG family: ABC-typedipeptide_oligopeptide_nickel transport systems_ permeasecomponents; Orthologue of BL1387 YP_909925.1 COG family: ABC-typedipeptide_oligopeptide_nickel transport systems_periplasmic components; Orthologue of BL1386; PFAM_ID:SBP_bac_5 YP_909926.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_909927.1 Orthologue of BL0932_nfa46550 YP_909928.1 Orthologue of BL0932_SCO3110_nfa46550 YP_909929.1 COG family: prephenate dehydrogenase; Orthologue of BL1382; PFAM_ID: PDH YP_909930.1 COG family: prephenate dehydratase; Orthologue of BL1381; PFAM_ID: ACT; PFAM_ID:PDT YP_909931.1 Orthologue of BL1380 YP_909932.1 COG family: predicted membrane GTPase involved instress response; Orthologue of BL1379; PFAM_ID: GTP_EFTU YP_909933.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL1378; PFAM_ID: sugar_tr YP_909934.1 COG family: ADP-ribose pyrophosphatase; Orthologue of BL1373; PFAM_ID:NUDIX YP_909935.1 COG family: ATPases involved in chromosomepartitioning; Orthologue of BL1370; PFAM_ID: ParA; PFAM_ID: fer4_NifH YP_909936.1 COG family: integrase; Orthologue of BL1368; PFAM_ID: Phage_integrase YP_909937.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_909938.1 COG family: ribosomal protein L35; Orthologue of BL1366a; PFAM_ID:Ribosomal_L35p YP_909939.1 COG family: translation initiation factorIf3; Orthologue of BL1366; PFAM_ID: IF3 YP_909940.1 Aspartate family; Orthologue of L0095 YP_909941.1 Orthologue of BL1364 YP_909942.1 COG family:glyceraldehyde-3- phosphatedehydrogenase_erythrose-4-phosphate dehydrogenase; Orthologue of BL1363; PFAM_ID: GpdH; PFAM_ID: gpdh_C YP_909943.1 COG family: uncharacterized Acr; Orthologue of BL1362 YP_909944.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_909945.1 COG family: galactose mutarotase and relatedenzymes; Orthologue of BL1359; PFAM_ID: Aldose_epim YP_909946.1 Orthologue of BL1358 YP_909947.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_909948.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_909949.1 Orthologue of LSA0098 YP_909950.1 Orthologue of L92665; murein sacculusand peptidoglycan provides D-aspartate_ which plays arole of cross-bridge during peptidoglycan networkformation YP_909951.1 COG family: folylpolyglutamatesynthase; Orthologue of BL1353; PFAM_ID: Mur_ligase YP_909952.1 Orthologue of BL1350; PFAM_ID: Peptidase_M24 YP_909953.1 COG family: NTP pyrophosphohydrolases includingoxidative damage repair enzymes; Orthologue of BL1349; PFAM_ID: NUDIX YP_909954.1 Identified by sequence similarity; Orthologue of Lxx08560_BL1348 YP_909955.1 COG family: ABC-type dipeptide_oligopeptide_nickeltransport systems_ permease components; Orthologue of BL1347 YP_909956.1 COG family: ABC-type dipeptide_oligopeptide_nickeltransport systems_ permease components; Orthologue of BL1346; PFAM_ID:BPD_transp YP_909957.1 COG family: ABC-type dipeptide_oligopeptide_nickeltransport systems_ periplasmic components; Orthologue of BL1345; PFAM_ID:SBP_bac_5 YP_909958.1 COG family: transcriptional regulators; Orthologue of BL1340; PFAM_ID:ROK YP_909959.1 COG family: sugar kinases_ ribokinase family; Orthologue of BL1339; PFAM_ID: pfkB YP_909960.1 Orthologue of Plut_0902 YP_909961.1 COG family: predicted flavin-nucleotide-bindingprotein structurally related to pyridoxine 5'-phosphateoxidase; Orthologue of BL1445 YP_909962.1 Identified by sequence similarity; Orthologue of Lxx15240 YP_909963.1 COG family: UDP-N-acetylmuramate-alanine ligase; Orthologue of BL1324; PFAM_ID:Mur_ligase; UDP-N-acetylmuramoyl-L-alanine synthetase YP_909964.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_909965.1 COG family: bacterial cell division membraneprotein; Orthologue of BL1322; PFAM_ID: FTSW_RODA_SPOVE YP_909966.1 COGfamily: UDP-N-acetylmuramoylalanine-D-glutamate ligase; Orthologue of BL1321; PFAM_ID: Mur_ligase; UDP-N-acetylmuramoyl-L-alanyl-D- glutamatesynthetase YP_909967.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_909968.1 COG family:UDP-N-acetylmuramyl pentapeptide synthase; Orthologue of BL1319; PFAM_ID:Mur_ligase; UDP-MurNAc-pentapeptide synthetase YP_909969.1 COG family: UDP-N-acetylmuramyl tripeptidesynthase; Orthologue of BL1318 YP_909970.1 COG family: cell divisionprotein FtsI_penicillin-binding protein 2; Orthologue of BL1317; PFAM_ID:Transpeptidase YP_909971.1 Orthologue of SCO2091 YP_909972.1 COG family: predicted S-adenosylmethionine-dependent methyltransferase involvedin cell envelope biogenesis; Orthologue of BL1316; PFAM_ID: Methyltransf_5 YP_909973.1 COG family: uncharacterized Bcr; Orthologue of BL1315; PFAM_ID: UPF0040 YP_909974.1 Orthologue of BL1314 YP_909975.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_909976.1 COG family: predicted transcriptional regulator_consists of a Zn-ribbon and ATP-cone domains; Orthologue of BL1312; PFAM_ID:DUF193 YP_909977.1 Orthologue of BL1311 YP_909978.1 Represses a number of genes involved in the response to DNA damage YP_909979.1 COG family: Co_Zn_Cd efflux system component; Orthologue of BL1309; PFAM_ID: Cation_efflux YP_909980.1 COG family: malate_lactate dehydrogenases; Orthologue of BL1308; PFAM_ID: Ldh; PFAM_ID: ldh_C YP_909981.1 COG family: GTPases; Orthologue of BL1307 YP_909982.1 COG family: 16s RNA g1207 methylase RsmC; Orthologue of BL1306 YP_909983.1 Orthologue of ECs2015_BL1305 YP_909984.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_3224 YP_909985.1 Orthologue of BL1304 YP_909986.1 Orthologue of Tfu_0982_ BL1302 YP_909987.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis YP_909988.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_909989.1 Orthologue of BCZK0765 YP_909990.1 catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis YP_909991.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_909992.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_909993.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_909994.1 COG family: pseudouridylate synthases_ 23SRNA-specific; Orthologue of BL0123; PFAM_ID: PseudoU_synth_2 YP_909995.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_909996.1 COG family: ATPase involved in DNA repair; Orthologue of BL0121 YP_909997.1 COG family: predicted integral membrane protein; Orthologue of BL0120 YP_909998.1 COG family: uncharacterized Bcr; Orthologue of BL0119 YP_909999.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_910000.1 COG family: predicted TIM-barrel enzymes_ possiblydehydrogenases_ NifR3 family; Orthologue of BL0117; PFAM_ID: UPF0034 YP_910001.1 Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_910002.1 Orthologue of NCgl0947 YP_910003.1 Orthologue of mll3846 YP_910004.1 Orthologue of CPS_3642; Permease protein YP_910005.1 Orthologue of lmo2592 YP_910006.1 MarR family; Orthologue of ABC2794 YP_910007.1 4-methyl-5-beta-hydroxyethylthiazole kinase; COG family: hydroxyethylthiazole kinase_sugar kinase family; Orthologue of BL0115; PFAM_ID: HK YP_910008.1 COG family: thiamine biosynthesisprotein ThiC; Orthologue of BL0114; PFAM_ID: TMP-TENI; PFAM_ID: ThiC YP_910009.1 COGfamily: hydroxymethylpyrimidine_phosphomethylpyr imidinekinase; HMP-phosphate kinase; HMP-P kinas; Orthologue of BL0113 YP_910010.1 COG family: uncharacterized Acr; Orthologue of BL0112; PFAM_ID: DUF77 YP_910011.1 COG family: transcriptional regulators; Orthologue of BL0107; PFAM_ID: Peripla_BP_like; PFAM_ID:lacI YP_910012.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_910013.1 COG family: beta-fructosidases(levanase_invertase); Orthologue of BL0105; PFAM_ID: Glyco_hydro_32 YP_910014.1 COG family: ABC- typenitrate_sulfonate_taurine_bicarbonate transport systems_permease components; Orthologue of BL0104 YP_910015.1 COG family: ABC- typenitrate_sulfonate_taurine_bicarbonate transport systems_periplasmic components; Orthologue of BL0103 YP_910016.1 COG family: inosine-uridine nucleosideN-ribohydrolase; Orthologue of BL0102; PFAM_ID: IU_nuc_hydro YP_910017.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_910018.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_910019.1 COG family: hydrolases of the alpha_betasuperfamily; Orthologue of BL0099 YP_910020.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_910021.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_910022.1 Orthologue of BL0096 YP_910023.1 Orthologue of BL0095 YP_910024.1 COG family: predicted secreted protein containing aPDZ domain; Orthologue of BL0094 YP_910025.1 Orthologue of BL0093 YP_910026.1 COG family: superfamily I DNA and RNAhelicases; Orthologue of BL0092; PFAM_ID: UvrD-helicase; UvrD YP_910027.1 Orthologue of BL0091 YP_910028.1 COG family: predicted metal-dependentphosphoesterases (Php family); Orthologue of BL0089; PFAM_ID: PHP_N YP_910029.1 Orthologue of BL0088 YP_910030.1 COG family: diaminopimelateepimerase; Dap epimerase; Orthologue of BL0087; PFAM_ID: DAP_epimerase YP_910031.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_910032.1 COG family: predicted esterase of the alpha-betahydrolase superfamily; Orthologue of BL0085 YP_910033.1 COG family: PLP-dependent aminotransferase; Orthologue of BL1268; PFAM_ID: aminotran_1_2 YP_910034.1 COG family: uncharacterized membrane protein; Orthologue of BL0471 YP_910035.1 COG family: ABC-typedipeptide_oligopeptide_nickel transport systems_periplasmic components; Orthologue of BL1386; PFAM_ID:SBP_bac_5 YP_910036.1 COG family:asparaginase; Orthologue of BL1142; PFAM_ID: Asparaginase_2 YP_910037.1 Orthologue of TTE0858 YP_910038.1 Orthologue of MS0131 YP_910039.1 Orthologue of spr0281 YP_910040.1 Orthologue of CE1244 YP_910041.1 Orthologue of CE1245 YP_910042.1 CRISPR-associated factor cas2 simular to S. pyogenes; Orthologue of cas2 YP_910043.1 Orthologue of ABC3592_BH0341; Protein unknown function DUF48 YP_910044.1 COG1468; CRISPR-associated protein; Domain of unknown function DUF83; Exonuclease_RecB family; Orthologue of ABC3593_Cag_1006_SPy1563 YP_910045.1 Family of unknown function (DUF694)_pfam05107; Orthologue of ebA3286 YP_910046.1 Orthologue of ebA3288 YP_910047.1 Orthologue of Cag_1008_BH0338 YP_910048.1 Orthologue of ebA3290 YP_910049.1 Orthologue of ebA3291_BH0336 YP_910050.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin) YP_910051.1 COG family: Na+_melibiose symporter andrelated transporters; Orthologue of BL0976 YP_910052.1 COG family: transcriptional regulators; Orthologue of BL1774; PFAM_ID:lacI YP_910053.1 Orthologue of BL1628 YP_910054.1 ATP-binding transmembrane protein; Orthologue of CAC3415_BL1767 YP_910055.1 COG family: ABC-type multidrug_protein_lipidtransport system_ ATPase component; Orthologue of BL1766; PFAM_ID: ABC_membrane; PFAM_ID: ABC_tran YP_910056.1 COG family: transcriptional regulators; Orthologue of BL1765; PFAM_ID:MarR YP_910057.1 Orthologue of nfa29580 YP_910058.1 COG family: transcriptional regulator; Orthologue of BL1756; PFAM_ID:tetR YP_910059.1 COG family: glycerate kinase; Orthologue of BL0845; PFAM_ID:DUF168 YP_910060.1 COG family: beta-glucosidase-relatedglycosidases; Gentiobiase; Orthologue of BL1757; PFAM_ID: Glyco_hydro_3 YP_910061.1 COG family: transcriptional regulator; Orthologue of BL1756; PFAM_ID:tetR YP_910062.1 Orthologue of PPA1284 YP_910063.1 Orthologue of BLi00227 YP_910064.1 COG family: transcriptional regulator; Orthologue of BL1756; PFAM_ID:tetR YP_910065.1 COG family: endoglucanase; Orthologue of BL1761 YP_910066.1 Orthologue of BH3683 YP_910067.1 COG family: endoglucanase; Orthologue of BL1761 YP_910068.1 Orthologue of BH1874 YP_910069.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0777 YP_910070.1 COG family: transcriptional regulator; Orthologue of BL1756; PFAM_ID:tetR YP_910071.1 Orthologue of plu2272; Similar to glucosylceramidase YP_910072.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0777 YP_910073.1 COG family: transcriptional regulator; Orthologue of BL1756; PFAM_ID:tetR YP_910074.1 Orthologue of SCO7407_BL1168 YP_910075.1 COG family: transcriptional regulator; Orthologue of BL1756; PFAM_ID:tetR YP_910076.1 COG family: gamma-glutamylcysteine synthetase; Gamma-glutamylcysteine synthetase; Orthologue of BL1755 YP_910077.1 Orthologue of L104115_BL1754; Similar to activator of (R)-2-hydroxyglutaryl-CoAdehydratase of Acidaminococcus fermentans YP_910078.1 COG family: organic radical activatingenzymes; Class III anaerobic ribonucleotide reductase smallcomponent; Orthologue of BL1753 YP_910079.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_910080.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_910081.1 Orthologue of bll6794 YP_910082.1 Orthologue of BL1743 YP_910083.1 COG0845; Orthologue of HCH_01961 YP_910084.1 CE3P009_ similar to PIR:S76704 percent identity: 37in 153 aa; Orthologue of CE3P009 YP_910085.1 Orthologue of BL1096 YP_910086.1 COG family: exopolyphosphatase; Orthologue of BL1742; PFAM_ID: Ppx-GppA YP_910087.1 COG family: PLP-dependent aminotransferases; Orthologue of BL1741; PFAM_ID: aminotran_1_2 YP_910088.1 Orthologue of BL1739 YP_910089.1 COG family: predicted dehydrogenases and relatedproteins; Orthologue of BL1740; PFAM_ID: GFO_IDH_MocA YP_910090.1 Orthologue of YPO1440 YP_910091.1 COG family: predicted restriction endonuclease; Orthologue of BL0565 YP_910092.1 Orthologue of LMOf2365_0325 YP_910093.1 Orthologue of BCE1021; SNF2 family YP_910094.1 Orthologue of BCE1020 YP_910095.1 Orthologue of BL0563 YP_910096.1 COGfamily: site-specific DNA methylase; Cytosine-specific methyltransferase Sau3AI; Orthologue of BL0564; PFAM_ID:DNA_methylase YP_910097.1 Orthologue of BL0039 YP_910098.1 Orthologue of Rts1_137 YP_910099.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_3414 YP_910101.1 Orthologue of SCO0948_BL1327_BL1328_BL1329 YP_910102.1 Orthologue of PF1851; Putative hth-type transcriptional regulatoryprotein YP_910103.1 Orthologue of TDE1708 YP_910104.1 Similar to replicase of Bifidobacterium asteroidesplasmid pAP1 encoded by GenBank Accession Number Y11549 YP_910105.1 COG family: serine_threonine protein kinases; Orthologue of BL1477 YP_910106.1 Orthologue of nfa36670 YP_910107.1 Orthologue of BL1479 YP_910108.1 Orthologue of PP0700 YP_910109.1 Orthologue of BL1481 YP_910110.1 Orthologue of BH2970 YP_910111.1 COG family: ATP-dependent Lon protease_ bacterialtype; Orthologue of BL1483 YP_910112.1 Orthologue of BL1484 YP_910113.1 Orthologue of BL1485 YP_910114.1 Orthologue of gbs0828; Similar to unknown proteins YP_910115.1 Orthologue of BL1486a YP_910116.1 Orthologue of XAC3660 YP_910117.1 Orthologue of MA2939 YP_910118.1 Orthologue of BURPS1710b_2649 YP_910119.1 Orthologue of SSP0620 YP_910120.1 Identified by match to protein family HMM PF05591; Orthologue of BURPS1710b_A1695 YP_910122.1 Identified by Glimmer2; putative; Orthologue of TDE2362 YP_910123.1 Orthologue of BLi00418 YP_910124.1 Orthologue of STH257 YP_910125.1 Orthologue of PP4452 YP_910126.1 Orthologue of BL1467 YP_910127.1 Orthologue of c4663 YP_910128.1 Orthologue of XCV3785_lpl1808; Similar to proline iminopeptidase YP_910130.1 LuxR family; Orthologue of BMA3290 YP_910131.1 LuxR family; Orthologue of BMA3290 YP_910132.1 Orthologue of STH3037 YP_910133.1 Orthologue of SCO6919 YP_910134.1 Catalyzes the formation of spermidine fromputrescine and S-adenosylmethioninamine; Orthologue of STM0166 YP_910135.1 Orthologue of pnf2870 YP_910136.1 Orthologue of CE3P009 YP_910137.1 Orthologue of MYPE1730 YP_910138.1 Orthologue of M6_Spy1667 YP_910139.1 Orthologue of DP2366 YP_910140.1 Orthologue of STH2159 YP_910141.1 Orthologue of XAC1815 YP_910142.1 Orthologue of Atu5353 YP_910143.1 Orthologue of BC0939 YP_910144.1 Orthologue of BC0940 YP_910145.1 Orthologue of kpn2kIR YP_910146.1 Orthologue of Kpn2 YP_910147.1 Defines one boundary of pathogenicity island; Orthologue of p103_22 YP_910148.1 Identified by Glimmer2; putative; Orthologue of SERP2454 YP_910149.1 Orthologue of PFL_4163 YP_910150.1 Function Code: 5.1 Central Intermediary Metabolism:Degradation of polysaccharides; Orthologue of PF0442 YP_910151.1 Orthologue of lmo1732; Permease protein YP_910152.1 Orthologue of PD1465 YP_910153.1 Orthologue of lin1841 YP_910154.1 Orthologue of SRU_2839 YP_910155.1 COG family: DNA polymerase III epsilon subunit andrelated 3'-5' exonucleases; COG0847 YP_910156.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_910157.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_910158.1 Orthologue of Rv2467_BL1191; Probable pepN_aminopeptidase N (EC 3.4.11.2) YP_910159.1 Orthologue of Tfu_0792_BL1192 YP_910160.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_910161.1 Orthologue of PA1626 YP_910162.1 Orthologue of YPTB0864 YP_910163.1 Orthologue of SAV1996 YP_910164.1 Orthologue of SMa1013; Silver efflux P-type ATPase [Psychrobacter arcticus 273-4]; Start changed for RBS and homology with other ATPases YP_910165.1 COG family: uncharacterized Bcr; Orthologue of BL0408; PFAM_ID: DUF156 YP_910166.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_910167.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL1195 YP_910168.1 COG family: superfamily I DNA and RNA helicases; Orthologue of BL1196; PFAM_ID:UvrD-helicase YP_910169.1 COG family: superfamily I DNA and RNA helicases; Orthologue of BL1197 YP_910170.1 COG family: superfamily I DNA and RNA helicases; Identified by Glimmer2; putative; Orthologue of BMAA1451.2 YP_910171.1 Orthologue of LSA1706 YP_910172.1 Orthologue of BL1013 YP_910173.1 COG family: serine_threonine protein kinases; PFAM_ID: pkinase YP_910174.1 Orthologue of BL1199 YP_910175.1 COG family: MoxR-like ATPases; Orthologue of BL1199a; PFAM_ID:Mg_chelatase YP_910176.1 COG family: uncharacterized Acr; Orthologue of BL1200; PFAM_ID: DUF58 YP_910177.1 COG family: transglutaminase-like enzymes_ putativecysteine proteases; Orthologue of BL1201; PFAM_ID: Transglut_core YP_910178.1 COG family: protein serine_threoninephosphatases; Orthologue of BL1202; PFAM_ID: PP2C YP_910179.1 Orthologue of BL1551 YP_910180.1 Orthologue of ACIAD0295 YP_910181.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_910182.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_910183.1 Orthologue of BL1206 YP_910184.1 COG family: A_G-specific DNA glycosylase; Orthologue of BL1207; PFAM_ID: HhH-GPD YP_910185.1 COG family: predicted rRNA methylase (SpoUclass); Orthologue of BL1208; PFAM_ID: SpoU_methylase YP_910186.1 COG family: uncharacterized Acr; Orthologue of BL1209 YP_910187.1 ACT domain-containing protein YP_910188.1 Orthologue of BLi04178 YP_910189.1 COG family: transcriptional regulators; Orthologue of BL0107; PFAM_ID: Peripla_BP_like; PFAM_ID:lacI YP_910190.1 Orthologue of BSU30090 YP_910191.1 Orthologue of ABC3118 YP_910192.1 Orthologue of ABC0361 YP_910193.1 Orthologue of SP1796; Substrate-binding protein YP_910194.1 COG family: galactokinase; Orthologue of BL1210; PFAM_ID: GHMP_kinases YP_910195.1 COG family: galactose-1- phosphateuridylyltransferase; Orthologue of BL1211; PFAM_ID: GalP_UDP_transf; PFAM_ID:GalP_UDP_tr_C YP_910196.1 COG family: transcriptional regulators of sugarmetabolism; Orthologue of BL1212; PFAM_ID: deoR; PFAM_ID: gntR YP_910197.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_910198.1 COG family: NADH; Orthologue of BL1214; PFAM_ID: oxidored_FMN YP_910199.1 COG family: membrane carboxypeptidase(penicillin-binding protein); Orthologue of BL1215; PFAM_ID: Transglycosyl; PFAM_ID: Transpeptidase YP_910200.1 COG family: cAMP-binding domains - catabolite geneactivator and regulatory subunit of cAMP-dependent proteinkinases; Orthologue of BL1216; PFAM_ID: cNMP_binding; PFAM_ID: crp YP_910201.1 COG family: lipoate-protein ligase A; Orthologue of BL1217; PFAM_ID: BPL_LipA_LipB YP_910202.1 COG family: predicted membrane protein; Orthologue of BL0040 YP_910203.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_910204.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_0275 YP_910205.1 COG family: protease II; Orthologue of BL1219; PFAM_ID: Peptidase_S9; oligo peptidase B; PtrB YP_910206.1 Orthologue of BL1220 YP_910207.1 COG family: glycine cleavage system H protein(lipoate-binding); Orthologue of BL1221; PFAM_ID: GCV_H YP_910208.1 COG family: uncharacterized Bcr; Orthologue of BL1154 YP_910209.1 COG family: NTP pyrophosphohydrolases containing aZn-finger_ probably nucleic-acid-binding; Orthologue of BL1222; PFAM_ID: NUDIX YP_910210.1 COG family: predicted hydrolases oracyltransferases (alpha_beta hydrolase superfamily); Orthologue of BL1223; PFAM_ID: abhydrolase YP_910211.1 Orthologue of BL1224 YP_910212.1 COG family: thiol-disulfide isomerase andthioredoxins; Orthologue of BL1226; PFAM_ID: thiored YP_910213.1 COG family: uncharacterized Bcr; Orthologue of BL1227 YP_910214.1 Orthologue of MSC_0013 YP_910215.1 Orthologue of BL0054 YP_910216.1 COG family: ribosomal protein L11; Orthologue of BL1230 YP_910217.1 Orthologue of BL1511 YP_910218.1 Orthologue of MM2895 YP_910219.1 Orthologue of BL0158 YP_910220.1 COG family: protein-tyrosine-phosphatase; Orthologue of BL0248; PFAM_ID:LMWPc YP_910221.1 COG family: ATPases involved in chromosomepartitioning; Orthologue of BL1229 YP_910222.1 Orthologue of EF3176 YP_910223.1 Orthologue of VPA1455 YP_910224.1 Orthologue of Tcr_0703; Rne/Rng family YP_910225.1 Orthologue of lmo1415 YP_910226.1 Identified by sequence similarity; Orthologue of Lxx08530; Solute-binding protein YP_910227.1 Orthologue of cg2040 YP_910228.1 Orthologue of RSc2066 YP_910229.1 Orthologue of CE1462 YP_910230.1 Orthologue of bll2163 YP_910231.1 Orthologue of Cag_1061 YP_910232.1 Identified by match to PFAM protein family HMMPF00665; Orthologue of SAG1229 YP_910233.1 Orthologue of SAG1270 YP_910234.1 Orthologue of BT1223 YP_910235.1 Identified by match to protein family HMM PF05193; Orthologue of PFL_5859_BLi03533 YP_910237.1 Identified by sequence similarity; putative; Orthologue of Atu5353 YP_910238.1 Orthologue of CE1244 YP_910239.1 Orthologue of CE1245 YP_910240.1 Orthologue of Rv3474; Possible transposase YP_910241.1 Orthologue of XF1091 YP_910242.1 Orthologue of BLi00680 YP_910243.1 Orthologue of BT1710 YP_910244.1 Identified by sequence similarity; Orthologue of CV3007 YP_910245.1 Orthologue of BF0187; Similar to Lactobacillus delbrueckiiglycosyltransferase EpsJ YP_910246.1 Orthologue of BF2794; Similar to Bacteroides thetaiotaomicron conservedhypothetical protein BT0042 YP_910247.1 Orthologue of ebA5878; Similar to Protein capG_ involved in capsularpolysaccharide (CPS) biosynthesis YP_910248.1 Orthologue of BF0187; Similar to Lactobacillus delbrueckiiglycosyltransferase EpsJ YP_910249.1 COG family: membrane protein involved in the exportof O-antigen and teichoic acid; Orthologue of BL0230; PFAM_ID: Polysacc_synt YP_910250.1 Orthologue of BSU30910 YP_910251.1 Orthologue of SP0353 YP_910252.1 COG family: sugar transferases involved inlipopolysaccharide synthesis; Orthologue of BL0237; PFAM_ID: Bact_transf YP_910253.1 Orthologue of BL1084 YP_910254.1 Orthologue of BL1743 YP_910255.1 Orthologue of cg0150 YP_910256.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0251 YP_910257.1 Orthologue of BURPS1710b_1550 YP_910258.1 COG family: Mn2+ and Fe2+ transporters of theNramp family; Orthologue of BL0252; PFAM_ID: Nramp YP_910259.1 COG family: aldo_keto reductases_ related todiketogulonate reductase; Orthologue of BL0255; PFAM_ID: aldo_ket_red YP_910260.1 Orthologue of BL0254 YP_910261.1 Orthologue of BL1628 YP_910262.1 Orthologue of NMA1364 YP_910263.1 COG family: transcriptional regulators; Orthologue of BL0258; PFAM_ID:lacI YP_910264.1 COG family: beta-galactosidase; Orthologue of BL0259; PFAM_ID: Glyco_hydro_42; lactase YP_910265.1 Orthologue of BT4160 YP_910266.1 Orthologue of OB2568 YP_910267.1 Orthologue of TTE0800 YP_910268.1 Orthologue of SMc02873 YP_910269.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_910270.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_910271.1 COG family: ABC-type multidrug_protein_lipidtransport system_ ATPase component; Orthologue of BL0264; PFAM_ID: ABC_membrane; PFAM_ID: ABC_tran YP_910272.1 COG family: long-chain acyl-CoA synthetases(AMP-forming); Orthologue of BL0266; PFAM_ID: AMP-binding YP_910273.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_910274.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate YP_910275.1 Orthologue of BLi02062_BL0274 YP_910276.1 COG family: transcriptional regulators; Orthologue of BL0275; PFAM_ID:lacI YP_910277.1 COG family: nucleotide-binding protein implicatedin inhibition of septum formation; Orthologue of BL1276; PFAM_ID: Maf; PFAM_ID:NUDIX YP_910278.1 COG family: homoserine kinase; Orthologue of BL1275; PFAM_ID:GHMP_kinases YP_910279.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_910280.1 COG family:diaminopimelate decarboxylase; Orthologue of BL1273; PFAM_ID: Orn_Arg_deC_N; PFAM_ID: Orn_DAP_Arg_deC YP_910281.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_910282.1 COG family: amino acid transporters; Orthologue of BL0758; PFAM_ID:aa_permeases YP_910283.1 COG family: putative translation initiationinhibitor; Orthologue of BL0348; PFAM_ID: UPF0076 YP_910284.1 COG family: thioredoxin domain-containing protein; Orthologue of BL0350 YP_910285.1 Orthologue of BL0352 YP_910286.1 Orthologue of BL0353 YP_910287.1 COG family: FkbP-typepeptidyl-prolyl cis-trans isomerases 1; Orthologue of BL0354; PFAM_ID: FKBP YP_910288.1 COG family: predicted nuclease of the RecB family; Orthologue of BL0355; PFAM_ID: DUF91 YP_910289.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex YP_910290.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_910291.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_910292.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_910293.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_910294.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_910295.1 COG family: F0F1-typeATP synthase C subunit_archaeal_vacuolar-type H+-ATPasesubunit K; Orthologue of BL0362; PFAM_ID: ATP-synt_C; lipid-binding protein YP_910296.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_910297.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_910298.1 COG family: glycosidases; Orthologue of BL0388; PFAM_ID: alpha-amylase YP_910299.1 ATP-binding protein; Identified by match to protein family HMM PF00005; Orthologue of LMOf2365_2627 YP_910300.1 Identified by match to protein family HMM PF06271; Orthologue of PFL_4645_GK1673 YP_910301.1 Orthologue of Mbar_A2147 YP_910302.1 Orthologue of LMOf2365_2630 YP_910303.1 Identified by similarity to GP:528976; Orthologue of LMOf2365_2631 YP_910304.1 Orthologue of SE0252 YP_910305.1 Orthologue of STH3220 YP_910306.1 Orthologue of CE2341 YP_910307.1 COGfamily: inorganic pyrophosphatase; Orthologue of BL0389; PFAM_ID:Pyrophosphatase; Pyrophosphate phospho-hydrolase YP_910308.1 COG family: predicted membrane protein; Orthologue of BL0390; PFAM_ID:DUF204 YP_910309.1 Orthologue of BL0391 YP_910310.1 COG family: response regulators consisting of aCheY-like receiver domain and a HTH DNA-binding domain; Orthologue of BL0392; PFAM_ID: trans_reg_C YP_910311.1 COGfamily: predicted endoIII-related endonuclease; DNA-(apurinic or apyrimidinic site lyase); Orthologue of BL0393; PFAM_ID:HhH-GPD YP_910312.1 COG family: ABC-type dipeptide_oligopeptide_nickeltransport systems_ periplasmic components; Orthologue of BL0394; PFAM_ID:SBP_bac_5 YP_910313.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_910314.1 COG family: methyl-accepting chemotaxis protein; Orthologue of BL0396 YP_910315.1 catalyzes the interconversion of chorismate to prephenate YP_910316.1 COG family: transcriptional regulators; Orthologue of BL0629; PFAM_ID:ASNC_trans_reg YP_910317.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_910318.1 COG family: protoporphyrinogen oxidase; Orthologue of BL0399 YP_910319.1 COG family: acetyltransferases_ includingN-acetylases of ribosomal proteins; Orthologue of BL0401; PFAM_ID: Acetyltransf YP_910320.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_910321.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_910322.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_910323.1 COG family: rRNA methylases; Orthologue of BL0405; PFAM_ID:SpoU_methylase YP_910324.1 COG family: orotate phosphoribosyltransferase; Orthologue of BL0406 YP_910325.1 COG family: uncharacterized Bcr; Orthologue of BL0407; PFAM_ID: DUF195 YP_910326.1 COG family: cation transport ATPases; Orthologue of BL0409; PFAM_ID: E1-E2_ATPase; PFAM_ID: Hydrolase YP_910327.1 Orthologue of Rv0384c_BL1250; Probable clpB(alternate gene name: htpM)_ endopeptidase ATP-bindingprotein_ chain B (EC 3.-.-.-) YP_910328.1 COG family: 2-keto-4-pentenoatehydratase_2- oxohepta-3-ene-1_7-dioic acid hydratase(catechol pathway); Orthologue of BL1247; PFAM_ID: FAA_hydrolase YP_910329.1 Orthologue of BL0678 YP_910330.1 Cna protein B-type domain; Orthologue of BL0675 YP_910331.1 Orthologue of BL1539 YP_910332.1 Orthologue of SAB0744 YP_910333.1 COG family: sortase (surface proteintranspeptidase); Orthologue of BL0498 YP_910334.1 COG family: predicted enzyme with a Tim-barrelfold; Orthologue of BL0419; PFAM_ID: UPF0001 YP_910335.1 Orthologue of ABC3794 YP_910336.1 COG family:glutamyl- and glutaminyl-tRNA synthetases; Glutamate--tRNA ligase; Orthologue of BL1251; PFAM_ID:tRNA-synt_1c YP_910337.1 Orthologue of SCO7229 YP_910338.1 COG family: glycerol uptake facilitator andrelated permeases (major intrinsic protein family); Orthologue of BL0410; PFAM_ID: MIP YP_910340.1 Identified by Glimmer2; putative; Identified by match to protein family HMM PF03372; Orthologue of BURPS1710b_2927_BURPS1710b_A0408 YP_910341.1 Orthologue of BL0417 YP_910342.1 Orthologue of RB950 YP_910343.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_910344.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_910345.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_910346.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_910347.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_910348.1 COG family: sugar kinases_ ribokinase family; Orthologue of BL1772; PFAM_ID: pfkB YP_910349.1 Orthologue of cg2168 YP_910350.1 Orthologue of BTH_I2472 YP_910352.1 Orthologue of FN1382 YP_910353.1 Orthologue of RS05312 YP_910354.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0920; PFAM_ID: sugar_tr; PFAM_ID:CBS YP_910355.1 COG family: S-adenosylmethionine synthetase; Orthologue of BL0921 YP_910356.1 Orthologue of BL0922 YP_910357.1 Orthologue of SAV5722 YP_910358.1 COG family: dTDP-D-glucose 4_6-dehydratase; Orthologue of BL0229; PFAM_ID: 3Beta_HSD; PFAM_ID: Epimerase YP_910359.1 Orthologue of nfa2110 YP_910360.1 COG family: phosphoglycerol transferase and relatedproteins_ alkaline phosphatase superfamily; Orthologue of BL0203 YP_910361.1 Orthologue of BF0187; Similar to Lactobacillus delbrueckiiglycosyltransferase EpsJ YP_910362.1 Identified by match to protein family HMM PF00535; Orthologue of TDE1433 YP_910363.1 COG family: ABC-type polysaccharide_polyolphosphate transport system_ ATPase component; Orthologue of BL0207; PFAM_ID:ABC_tran YP_910364.1 COG family: membrane permeases involved in cellwall biosynthesis; Orthologue of BL0208; PFAM_ID: ABC2_membrane YP_910365.1 Orthologue of mlr7560 YP_910366.1 Orthologue of Mbar_A2235 YP_910367.1 Orthologue of LMOf2365_2740 YP_910368.1 COG family: glycosyltransferases involved in cellwall biogenesis; Orthologue of BL0205; PFAM_ID: Glycos_transf_2 YP_910369.1 Orthologue of Pcar_1128 YP_910370.1 COG family: dTDP-D-glucose 4_6-dehydratase; Orthologue of BL0229; PFAM_ID: 3Beta_HSD; PFAM_ID: Epimerase YP_910371.1 COG family: dTDP-4-dehydrorhamnose 3_5-epimeraseand related enzymes; Orthologue of BL0228_cg0402; PFAM_ID: dTDP_sugar_isom; PFAM_ID:Epimerase YP_910374.1 Orthologue of spr1431 YP_910375.1 Orthologue of SAS2540; Similar to internal region of Streptococcusgordonii platelet binding protein GspB YP_910376.1 Orthologue of BT3124; Similar to human sialic acid-specificacetylesterase II YP_910377.1 Orthologue of mlr0587 YP_910378.1 Orthologue of MAP2018c YP_910379.1 Orthologue of LSA1873 YP_910380.1 Orthologue of Rv3779; Probableconserved transmembrane ala-_ leu-rich protein YP_910381.1 COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components YP_910382.1 COG family: ABC-type sugar (aldose) transportsystem_ ATPase component; COG family: ABC-type transport systems_ involved inlipoprotein release_ permease components; Orthologue of BL0197; PFAM_ID: ABC_tran YP_910383.1 COG family: predicted HD superfamily hydrolase; Orthologue of BL0196 YP_910384.1 COG family: predicted glutamine amidotransferase; Orthologue of BL0195 YP_910385.1 COG family: K+ transporter; Orthologue of BL0194; PFAM_ID: K_trans YP_910386.1 COG family: Mg-dependent DNase; Orthologue of BL0193; PFAM_ID:TatD_DNase YP_910387.1 COG family: alpha-L-arabinofuranosidase; Orthologue of BL0181 YP_910388.1 Orthologue of BL0177 YP_910389.1 COG family: transcriptional regulators; Orthologue of BL0176; PFAM_ID: Peripla_BP_like; PFAM_ID:lacI YP_910390.1 Orthologue of SAV6381 YP_910391.1 Orthologue of PPA2057 YP_910392.1 COG family: uncharacterized Bcr; Orthologue of BL0174 YP_910393.1 ATP-binding protein; Orthologue of BL0180_lin0155 YP_910394.1 COG family: ABC-type multidrug_protein_lipidtransport system_ ATPase component; Orthologue of BL0179; PFAM_ID: ABC_membrane; PFAM_ID: ABC_tran YP_910395.1 COG0657 Esterase-lipase; Orthologue of LBA1355 YP_910396.1 Orthologue of BL1631 YP_910397.1 Identified by match to protein family HMM PF00703;match to protein family HMM PF02837; Orthologue of TDE1730 YP_910398.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_910399.1 Orthologue of BL0168 YP_910400.1 Orthologue of BL0167 YP_910401.1 COG family: predicted methyltransferases; Orthologue of BL0166; PFAM_ID:TP_methylase YP_910402.1 Identified by Glimmer2; putative; Orthologue of BURPS1710b_2087 YP_910403.1 Orthologue of Bcep18194_B0045 YP_910404.1 COG family: predicted phosphatase_phosphohexomutase; Orthologue of BL0511; PFAM_ID: Hydrolase YP_910405.1 Orthologue of PG1691 YP_910406.1 Orthologue of SAV283 YP_910407.1 COG family: predicted transcriptional regulators; Orthologue of BL0516; PFAM_ID: merR YP_910408.1 COG family: molecular chaperones (containC-terminal Zn finger domain); Orthologue of BL0517; PFAM_ID: DnaJ; PFAM_ID:DnaJ_C YP_910409.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_910410.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_910411.1 Orthologue of ECs0433 YP_910412.1 COG family: predicted permeases; Orthologue of BL1515; PFAM_ID: DUF81 YP_910413.1 Orthologue of nfa13410 YP_910414.1 Identified by similarity to GB:AAC13546.1; match toprotein family HMM PF04203; match to protein family HMMTIGR01076; Orthologue of SAK_1439 YP_910415.1 Orthologue of SAS2578 YP_910416.1 Identified by match to protein family HMM PF00990;match to protein family HMM TIGR00254; Orthologue of PFL_0087 YP_910417.1 Orthologue of BF3410 YP_910418.1 Orthologue of alr9029 YP_910419.1 COG family: transcriptional regulators; Orthologue of BL0142; PFAM_ID: Peripla_BP_like; PFAM_ID:lacI YP_910420.1 No significant database matches; Orthologue of DIP0537 YP_910421.1 Orthologue of Nmul_A1707 YP_910422.1 Orthologue of BT4689_BT9727_2498 YP_910423.1 Amylomaltase; COG family:4-alpha-glucanotransferase; Orthologue of BL0527; PFAM_ID: 4A_glucanotrans YP_910424.1 COG family: glycosidases; Orthologue of BL0529; PFAM_ID:alpha-amylase YP_910425.1 COG family: 4-hydroxybenzoate polyprenyltransferaseand related prenyltransferases; Orthologue of BL0145 YP_910426.1 COG family: sugar permeases; Orthologue of BL0144; PFAM_ID: BPD_transp YP_910427.1 COG family: ABC-type sugar transport systems_permease components; Orthologue of BL0143; PFAM_ID: BPD_transp YP_910428.1 COG family: transcriptional regulators; Orthologue of BL0142; PFAM_ID: Peripla_BP_like; PFAM_ID:lacI YP_910429.1 Orthologue of BL0141 YP_910430.1 COG family: phosphoglyceratemutase_fructose-2_6- bisphosphatase; Orthologue of BL0140; PFAM_ID: PGAM YP_910431.1 COG family: nitroreductase; Flavin reductase P; NADPH-Fmn oxidoreductase; Orthologue of BL0139; PFAM_ID:Nitroreductase YP_910432.1 COG family: NAD-dependent protein deacetylases_Sir2 family; Orthologue of BL1528; PFAM_ID: SIR2 YP_910433.1 catalyzes the formation of 2-oxobutanoate from L-threonine YP_910434.1 COG family:glycosidases; Dextrin 6-alpha-D-glucanohydrolase; Orthologue of BL1526; PFAM_ID: alpha-amylase; Sucrase-isomaltase YP_910435.1 COG family: sugar permeases; Orthologue of BL1523; PFAM_ID:BPD_transp YP_910436.1 COG family: ABC-type sugar transport systems_permease components; Orthologue of BL1522; PFAM_ID: BPD_transp YP_910437.1 COG family: sugar-binding periplasmicproteins_domains; Orthologue of BL1521; PFAM_ID: SBP_bacterial_1 YP_910438.1 COG family: transcriptional regulators; Orthologue of BL1520; PFAM_ID:ROK YP_910439.1 COG family: alpha-galactosidase; Orthologue of BL1518; melibiase YP_910440.1 COG family: cytosine_adenosine deaminases; Orthologue of BL1517; PFAM_ID: dCMP_cyt_deam YP_910441.1 COG family: NhaP-type Na+_H+ and K+_H+ antiporters; Hydrogen exchanger family protein [Listeria monocytogenes str. 4b F2365]; Orthologue of BL1516; PFAM_ID: Na_H_Exchanger YP_910442.1 COG family: predicted esterase; Orthologue of BL1514; PFAM_ID:abhydrolase_2 YP_910443.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_910444.1 Orthologue of ABC2324 YP_910445.1 Orthologue of BH2723 YP_910446.1 COG family: uncharacterized Bcr; Orthologue of BL1731 YP_910447.1 Orthologue of SAV2569 YP_910448.1 Orthologue of SAV1028; PF00497: Bacterial extracellular solute-bindingproteins_ family 3 YP_910449.1 sugar; Identified by sequence similarity; Orthologue of Atu2506 YP_910450.1 Orthologue of TTE1936 YP_910451.1 Orthologue of SMb20234; Product confidence : hypothetical Gene name confidence : hypothetical YP_910452.1 LuxR; Orthologue of Reut_B3832 YP_910453.1 COG family: permeases of the major facilitatorsuperfamily; Orthologue of BL0681; PFAM_ID: sugar_tr YP_910454.1 Identified by sequence similarity; Orthologue of Lxx18230 YP_910455.1 Orthologue of BL0679 YP_910456.1 COG family: ABC- typesugar_spermidine_putrescine_iron_thiamine transportsystems_ ATPase component; Orthologue of BL0673; PFAM_ID: ABC_tran YP_910457.1 Orthologue of CPE1501; Similar to pir:S60139 virR protein from Clostridiumperfringens YP_910458.1 Orthologue of CPE1500; Similar to pir:C55521 virS protein from Clostridiumperfringens 5 putative transmembrane regions were found by PSORT. YP_910459.1 COG family: chloride channel protein EriC; Orthologue of BL0946; PFAM_ID:voltage_CLC YP_910460.1 Orthologue of STH952 YP_910461.1 Orthologue of nfa34000 YP_910462.1 Orthologue of spr0284 YP_910463.1 Orthologue of BH3445 YP_910464.1 Identified by match to protein family HMM PF03372; Orthologue of BURPS1710b_A0408 YP_910465.1 COG family:N-acetylglucosamine-6-phosphate deacetylase; GlcNAc 6-P deacetylase; Orthologue of BL1344; PFAM_ID:NagA YP_910466.1 Orthologue of SCO7407; Probable beta-galactosidase(EC 3.2.1.23) YP_910467.1 COG family: Na+_melibiose symporter andrelated transporters; Orthologue of BL0976 YP_910468.1 Orthologue of BH2723 YP_910469.1 COG family: transcriptional regulators; Orthologue of BL1774; PFAM_ID:lacI YP_910470.1 AraC family; Identified by match to protein family HMM PF00165;match to protein family HMM PF02311; Orthologue of SAK_1191 YP_910471.1 Identified by match to protein family HMM PF00583; Orthologue of TDE0035 YP_910472.1 Orthologue of SSP0040 YP_910473.1 Orthologue of TM0025 YP_910474.1 COG1472; Orthologue of VV21304 YP_910475.1 COG family: serine_threonine protein kinases; Orthologue of BL0660; PFAM_ID: pkinase YP_910476.1 COG family: protein-disulfide isomerase; Orthologue of BL0659 YP_910477.1 COG family: uncharacterized Bcr; Orthologue of BL0658 YP_910478.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_910479.1 COG family:4-diphosphocytidyl-2C-methyl-D- erythritol 2-phosphatesynthase; Orthologue of BL0656 YP_910480.1 Orthologue of BL0655 YP_910481.1 COG family: tRNA nucleotidyltransferase _poly(A) polymerase; Orthologue of BL0654; PFAM_ID: HD; PFAM_ID:PolyA_pol YP_910482.1 COG family: NTP pyrophosphohydrolases includingoxidative damage repair enzymes; Orthologue of BL0653; PFAM_ID: NUDIX YP_910483.1 Orthologue of BL0652 YP_910484.1 COG family: uncharacterized membrane protein_putative virulence factor; Orthologue of BL0651; PFAM_ID: MVIN YP_910485.1 Orthologue of BL0650 YP_910486.1 COG family: thioredoxin reductase; Orthologue of BL0649; PFAM_ID:pyr_redox; TrxB_ thioredoxin reductase (NADPH)_len: 322 aa; previously sequenced as SW:TRXB_STRCO(EMBL:AJ007313)_ TrxB. Contains PS00573 Pyridinenucleotide-disulphide oxidoreductases class-II active site YP_910487.1 COG family: predicted transcriptionalregulators; Orthologue of BL0648; PFAM_ID: ParBc YP_910488.1 COG family: ATPases involved in chromosomepartitioning; Orthologue of BL0647; PFAM_ID: ParA; PFAM_ID: fer4_NifH YP_910489.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_910490.1 COG family: predicted RNA-binding protein; Orthologue of BL0645; PFAM_ID: R3H YP_910491.1 COG family: preprotein translocase subunit YidC; Orthologue of BL0644; PFAM_ID: 60KD_IMP YP_910492.1 COG family: uncharacterized Acr; Orthologue of BL0643; PFAM_ID: DUF37 YP_910493.1 COG family: RNase P protein component; Orthologue of BL0642a; PFAM_ID: Ribonuclease_P YP_910494.1 COG family: ribosomal protein L34; Orthologue of BL0642; PFAM_ID:Ribosomal_L34