-- dump date 20140619_001657 -- class Genbank::misc_feature -- table misc_feature_note -- id note 367928000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 367928000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928000003 Walker A motif; other site 367928000004 ATP binding site [chemical binding]; other site 367928000005 Walker B motif; other site 367928000006 arginine finger; other site 367928000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 367928000008 DnaA box-binding interface [nucleotide binding]; other site 367928000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 367928000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 367928000011 putative DNA binding surface [nucleotide binding]; other site 367928000012 dimer interface [polypeptide binding]; other site 367928000013 beta-clamp/clamp loader binding surface; other site 367928000014 beta-clamp/translesion DNA polymerase binding surface; other site 367928000015 recombination protein F; Reviewed; Region: recF; PRK00064 367928000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928000017 Walker A/P-loop; other site 367928000018 ATP binding site [chemical binding]; other site 367928000019 Q-loop/lid; other site 367928000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928000021 Q-loop/lid; other site 367928000022 ABC transporter signature motif; other site 367928000023 Walker B; other site 367928000024 D-loop; other site 367928000025 H-loop/switch region; other site 367928000026 Protein of unknown function (DUF721); Region: DUF721; pfam05258 367928000027 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 367928000028 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 367928000029 anchoring element; other site 367928000030 dimer interface [polypeptide binding]; other site 367928000031 ATP binding site [chemical binding]; other site 367928000032 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 367928000033 active site 367928000034 putative metal-binding site [ion binding]; other site 367928000035 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 367928000036 DNA gyrase subunit A; Validated; Region: PRK05560 367928000037 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 367928000038 CAP-like domain; other site 367928000039 active site 367928000040 primary dimer interface [polypeptide binding]; other site 367928000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367928000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367928000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367928000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367928000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367928000046 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 367928000047 glutamate dehydrogenase; Provisional; Region: PRK09414 367928000048 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 367928000049 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 367928000050 NAD(P) binding site [chemical binding]; other site 367928000051 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 367928000052 Protein of unknown function DUF45; Region: DUF45; pfam01863 367928000053 Domain of unknown function DUF21; Region: DUF21; pfam01595 367928000054 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 367928000055 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 367928000056 Transporter associated domain; Region: CorC_HlyC; smart01091 367928000057 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 367928000058 active site clefts [active] 367928000059 zinc binding site [ion binding]; other site 367928000060 dimer interface [polypeptide binding]; other site 367928000061 RDD family; Region: RDD; pfam06271 367928000062 Primase C terminal 2 (PriCT-2); Region: PriCT_2; pfam08707 367928000063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928000064 AAA domain; Region: AAA_23; pfam13476 367928000065 Walker A/P-loop; other site 367928000066 ATP binding site [chemical binding]; other site 367928000067 BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418 367928000068 active site 367928000069 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 367928000070 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 367928000071 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 367928000072 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 367928000073 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 367928000074 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 367928000075 Na binding site [ion binding]; other site 367928000076 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 367928000077 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 367928000078 active site 367928000079 HIGH motif; other site 367928000080 dimer interface [polypeptide binding]; other site 367928000081 KMSKS motif; other site 367928000082 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 367928000083 homodimer interface [polypeptide binding]; other site 367928000084 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 367928000085 active site pocket [active] 367928000086 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 367928000087 putative septation inhibitor protein; Reviewed; Region: PRK02251 367928000088 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 367928000089 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 367928000090 active site 367928000091 catalytic site [active] 367928000092 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 367928000093 Glutamine amidotransferase class-I; Region: GATase; pfam00117 367928000094 glutamine binding [chemical binding]; other site 367928000095 catalytic triad [active] 367928000096 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 367928000097 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 367928000098 active site 367928000099 ATP binding site [chemical binding]; other site 367928000100 substrate binding site [chemical binding]; other site 367928000101 activation loop (A-loop); other site 367928000102 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 367928000103 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 367928000104 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 367928000105 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 367928000106 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 367928000107 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 367928000108 active site 367928000109 ATP binding site [chemical binding]; other site 367928000110 substrate binding site [chemical binding]; other site 367928000111 activation loop (A-loop); other site 367928000112 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 367928000113 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 367928000114 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 367928000115 active site 367928000116 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 367928000117 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 367928000118 phosphopeptide binding site; other site 367928000119 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 367928000120 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 367928000121 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 367928000122 phosphopeptide binding site; other site 367928000123 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 367928000124 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 367928000125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 367928000126 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 367928000127 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928000128 active site 367928000129 phosphorylation site [posttranslational modification] 367928000130 intermolecular recognition site; other site 367928000131 dimerization interface [polypeptide binding]; other site 367928000132 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 367928000133 DNA binding residues [nucleotide binding] 367928000134 dimerization interface [polypeptide binding]; other site 367928000135 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 367928000136 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 367928000137 EamA-like transporter family; Region: EamA; pfam00892 367928000138 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 367928000139 EamA-like transporter family; Region: EamA; pfam00892 367928000140 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 367928000141 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928000142 active site 367928000143 phosphorylation site [posttranslational modification] 367928000144 intermolecular recognition site; other site 367928000145 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 367928000146 DNA binding residues [nucleotide binding] 367928000147 dimerization interface [polypeptide binding]; other site 367928000148 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 367928000149 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 367928000150 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 367928000151 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 367928000152 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 367928000153 protein binding site [polypeptide binding]; other site 367928000154 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 367928000155 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 367928000156 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 367928000157 active site 367928000158 homodimer interface [polypeptide binding]; other site 367928000159 ferredoxin-NADP+ reductase; Region: PLN02852 367928000160 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 367928000161 heat shock protein HtpX; Provisional; Region: PRK03072 367928000162 aromatic amino acid exporter; Provisional; Region: PRK11689 367928000163 EamA-like transporter family; Region: EamA; pfam00892 367928000164 Predicted membrane protein [Function unknown]; Region: COG1511 367928000165 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 367928000166 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 367928000167 Predicted membrane protein [Function unknown]; Region: COG1511 367928000168 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 367928000169 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 367928000170 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 367928000171 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 367928000172 active site 367928000173 intersubunit interface [polypeptide binding]; other site 367928000174 zinc binding site [ion binding]; other site 367928000175 Na+ binding site [ion binding]; other site 367928000176 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 367928000177 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 367928000178 GDP-binding site [chemical binding]; other site 367928000179 ACT binding site; other site 367928000180 IMP binding site; other site 367928000181 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 367928000182 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 367928000183 Cl- selectivity filter; other site 367928000184 Cl- binding residues [ion binding]; other site 367928000185 pore gating glutamate residue; other site 367928000186 dimer interface [polypeptide binding]; other site 367928000187 H+/Cl- coupling transport residue; other site 367928000188 TrkA-C domain; Region: TrkA_C; pfam02080 367928000189 CrcB-like protein; Region: CRCB; pfam02537 367928000190 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 367928000191 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 367928000192 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 367928000193 TM-ABC transporter signature motif; other site 367928000194 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 367928000195 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 367928000196 TM-ABC transporter signature motif; other site 367928000197 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 367928000198 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 367928000199 Walker A/P-loop; other site 367928000200 ATP binding site [chemical binding]; other site 367928000201 Q-loop/lid; other site 367928000202 ABC transporter signature motif; other site 367928000203 Walker B; other site 367928000204 D-loop; other site 367928000205 H-loop/switch region; other site 367928000206 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 367928000207 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 367928000208 Walker A/P-loop; other site 367928000209 ATP binding site [chemical binding]; other site 367928000210 Q-loop/lid; other site 367928000211 ABC transporter signature motif; other site 367928000212 Walker B; other site 367928000213 D-loop; other site 367928000214 H-loop/switch region; other site 367928000215 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 367928000216 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 367928000217 ligand binding site [chemical binding]; other site 367928000218 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928000219 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928000220 DNA binding site [nucleotide binding] 367928000221 domain linker motif; other site 367928000222 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 367928000223 dimerization interface [polypeptide binding]; other site 367928000224 ligand binding site [chemical binding]; other site 367928000225 sodium binding site [ion binding]; other site 367928000226 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 367928000227 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 367928000228 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928000229 catalytic residue [active] 367928000230 hypothetical protein; Provisional; Region: PRK05463 367928000231 sucrose phosphorylase; Provisional; Region: PRK13840 367928000232 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 367928000233 active site 367928000234 homodimer interface [polypeptide binding]; other site 367928000235 catalytic site [active] 367928000236 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 367928000237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928000238 metabolite-proton symporter; Region: 2A0106; TIGR00883 367928000239 putative substrate translocation pore; other site 367928000240 ketol-acid reductoisomerase; Provisional; Region: PRK05479 367928000241 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 367928000242 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 367928000243 ketol-acid reductoisomerase; Provisional; Region: PRK05479 367928000244 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 367928000245 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 367928000246 Domain of unknown function (DUF303); Region: DUF303; pfam03629 367928000247 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 367928000248 FtsX-like permease family; Region: FtsX; pfam02687 367928000249 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 367928000250 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 367928000251 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 367928000252 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 367928000253 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 367928000254 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 367928000255 ThiS interaction site; other site 367928000256 putative active site [active] 367928000257 tetramer interface [polypeptide binding]; other site 367928000258 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 367928000259 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 367928000260 putative ATP binding site [chemical binding]; other site 367928000261 putative substrate interface [chemical binding]; other site 367928000262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 367928000263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 367928000264 active site 367928000265 catalytic tetrad [active] 367928000266 MarR family; Region: MarR; pfam01047 367928000267 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367928000268 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367928000269 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928000270 Walker A/P-loop; other site 367928000271 ATP binding site [chemical binding]; other site 367928000272 Q-loop/lid; other site 367928000273 ABC transporter signature motif; other site 367928000274 Walker B; other site 367928000275 D-loop; other site 367928000276 H-loop/switch region; other site 367928000277 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367928000278 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367928000279 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 367928000280 Walker A/P-loop; other site 367928000281 ATP binding site [chemical binding]; other site 367928000282 Q-loop/lid; other site 367928000283 ABC transporter signature motif; other site 367928000284 Walker B; other site 367928000285 D-loop; other site 367928000286 H-loop/switch region; other site 367928000287 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 367928000288 active site 367928000289 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 367928000290 catalytic tetrad [active] 367928000291 ApbE family; Region: ApbE; pfam02424 367928000292 Iron permease FTR1 family; Region: FTR1; cl00475 367928000293 Fe2+ transport protein; Region: Iron_transport; pfam10634 367928000294 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 367928000295 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928000296 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 367928000297 FtsX-like permease family; Region: FtsX; pfam02687 367928000298 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928000299 FtsX-like permease family; Region: FtsX; pfam02687 367928000300 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928000301 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367928000302 Walker A/P-loop; other site 367928000303 ATP binding site [chemical binding]; other site 367928000304 Q-loop/lid; other site 367928000305 ABC transporter signature motif; other site 367928000306 Walker B; other site 367928000307 D-loop; other site 367928000308 H-loop/switch region; other site 367928000309 FMN-binding domain; Region: FMN_bind; cl01081 367928000310 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367928000311 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928000312 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 367928000313 Predicted membrane protein [Function unknown]; Region: COG1511 367928000314 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 367928000315 Predicted membrane protein [Function unknown]; Region: COG1511 367928000316 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 367928000317 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747 367928000318 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 367928000319 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 367928000320 Peptidase family C69; Region: Peptidase_C69; pfam03577 367928000321 putative glycosyl transferase; Provisional; Region: PRK10073 367928000322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 367928000323 active site 367928000324 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367928000325 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928000326 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 367928000327 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 367928000328 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 367928000329 P loop; other site 367928000330 GTP binding site [chemical binding]; other site 367928000331 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 367928000332 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 367928000333 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 367928000334 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 367928000335 Nitrogen regulatory protein P-II; Region: P-II; smart00938 367928000336 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 367928000337 metal binding triad; other site 367928000338 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 367928000339 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 367928000340 replicative DNA helicase; Region: DnaB; TIGR00665 367928000341 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 367928000342 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 367928000343 Walker A motif; other site 367928000344 ATP binding site [chemical binding]; other site 367928000345 Walker B motif; other site 367928000346 DNA binding loops [nucleotide binding] 367928000347 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 367928000348 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367928000349 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 367928000350 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 367928000351 catalytic triad [active] 367928000352 Uncharacterized conserved protein [Function unknown]; Region: COG3937 367928000353 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 367928000354 ABC1 family; Region: ABC1; pfam03109 367928000355 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 367928000356 active site 367928000357 ATP binding site [chemical binding]; other site 367928000358 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 367928000359 active site 367928000360 catalytic site [active] 367928000361 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 367928000362 active site 367928000363 catalytic site [active] 367928000364 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 367928000365 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367928000366 active site 367928000367 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 367928000368 active site 367928000369 Ap6A binding site [chemical binding]; other site 367928000370 nudix motif; other site 367928000371 metal binding site [ion binding]; metal-binding site 367928000372 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928000373 catalytic core [active] 367928000374 polyphosphate kinase; Provisional; Region: PRK05443 367928000375 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 367928000376 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 367928000377 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 367928000378 putative domain interface [polypeptide binding]; other site 367928000379 putative active site [active] 367928000380 catalytic site [active] 367928000381 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 367928000382 putative domain interface [polypeptide binding]; other site 367928000383 putative active site [active] 367928000384 catalytic site [active] 367928000385 Type II/IV secretion system protein; Region: T2SE; pfam00437 367928000386 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 367928000387 ATP binding site [chemical binding]; other site 367928000388 Walker A motif; other site 367928000389 hexamer interface [polypeptide binding]; other site 367928000390 Walker B motif; other site 367928000391 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 367928000392 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 367928000393 diacylglycerol kinase; Reviewed; Region: PRK11914 367928000394 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 367928000395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367928000396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928000397 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 367928000398 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928000399 Walker A motif; other site 367928000400 ATP binding site [chemical binding]; other site 367928000401 Walker B motif; other site 367928000402 arginine finger; other site 367928000403 recombination protein RecR; Reviewed; Region: recR; PRK00076 367928000404 RecR protein; Region: RecR; pfam02132 367928000405 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 367928000406 putative active site [active] 367928000407 putative metal-binding site [ion binding]; other site 367928000408 tetramer interface [polypeptide binding]; other site 367928000409 aspartate kinase; Reviewed; Region: PRK06635 367928000410 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 367928000411 putative nucleotide binding site [chemical binding]; other site 367928000412 putative catalytic residues [active] 367928000413 putative Mg ion binding site [ion binding]; other site 367928000414 putative aspartate binding site [chemical binding]; other site 367928000415 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 367928000416 putative allosteric regulatory site; other site 367928000417 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 367928000418 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 367928000419 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 367928000420 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 367928000421 Double zinc ribbon; Region: DZR; pfam12773 367928000422 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 367928000423 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 367928000424 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 367928000425 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 367928000426 metal binding site [ion binding]; metal-binding site 367928000427 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 367928000428 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 367928000429 2-isopropylmalate synthase; Validated; Region: PRK03739 367928000430 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 367928000431 active site 367928000432 catalytic residues [active] 367928000433 metal binding site [ion binding]; metal-binding site 367928000434 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 367928000435 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 367928000436 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928000437 Walker A motif; other site 367928000438 ATP binding site [chemical binding]; other site 367928000439 Walker B motif; other site 367928000440 arginine finger; other site 367928000441 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 367928000442 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 367928000443 DNA-binding interface [nucleotide binding]; DNA binding site 367928000444 Integrase core domain; Region: rve; pfam00665 367928000445 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 367928000446 active site 367928000447 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928000448 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928000449 DNA binding site [nucleotide binding] 367928000450 domain linker motif; other site 367928000451 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928000452 dimerization interface [polypeptide binding]; other site 367928000453 ligand binding site [chemical binding]; other site 367928000454 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 367928000455 active site 367928000456 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 367928000457 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 367928000458 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928000459 dimer interface [polypeptide binding]; other site 367928000460 conserved gate region; other site 367928000461 putative PBP binding loops; other site 367928000462 ABC-ATPase subunit interface; other site 367928000463 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 367928000464 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 367928000465 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928000466 dimer interface [polypeptide binding]; other site 367928000467 conserved gate region; other site 367928000468 putative PBP binding loops; other site 367928000469 ABC-ATPase subunit interface; other site 367928000470 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 367928000471 Transglycosylase; Region: Transgly; pfam00912 367928000472 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 367928000473 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 367928000474 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 367928000475 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 367928000476 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 367928000477 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 367928000478 UDP-galactopyranose mutase; Region: GLF; pfam03275 367928000479 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 367928000480 active site 367928000481 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 367928000482 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 367928000483 active site 367928000484 interdomain interaction site; other site 367928000485 putative metal-binding site [ion binding]; other site 367928000486 nucleotide binding site [chemical binding]; other site 367928000487 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 367928000488 domain I; other site 367928000489 phosphate binding site [ion binding]; other site 367928000490 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 367928000491 domain II; other site 367928000492 domain III; other site 367928000493 nucleotide binding site [chemical binding]; other site 367928000494 DNA binding groove [nucleotide binding] 367928000495 catalytic site [active] 367928000496 domain IV; other site 367928000497 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 367928000498 thymidylate kinase; Validated; Region: tmk; PRK00698 367928000499 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 367928000500 TMP-binding site; other site 367928000501 ATP-binding site [chemical binding]; other site 367928000502 DNA polymerase III subunit delta'; Validated; Region: PRK07940 367928000503 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928000504 Walker A motif; other site 367928000505 ATP binding site [chemical binding]; other site 367928000506 Walker B motif; other site 367928000507 arginine finger; other site 367928000508 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928000509 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928000510 DNA binding site [nucleotide binding] 367928000511 domain linker motif; other site 367928000512 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928000513 dimerization interface [polypeptide binding]; other site 367928000514 ligand binding site [chemical binding]; other site 367928000515 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 367928000516 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 367928000517 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 367928000518 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 367928000519 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 367928000520 substrate binding site [chemical binding]; other site 367928000521 Peptidase family C69; Region: Peptidase_C69; pfam03577 367928000522 tellurium resistance terB-like protein; Region: terB_like; cl11965 367928000523 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 367928000524 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 367928000525 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 367928000526 Predicted membrane protein [Function unknown]; Region: COG2246 367928000527 GtrA-like protein; Region: GtrA; pfam04138 367928000528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928000529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928000530 putative substrate translocation pore; other site 367928000531 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928000532 catalytic core [active] 367928000533 Protein of unknown function (DUF805); Region: DUF805; pfam05656 367928000534 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 367928000535 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 367928000536 HIGH motif; other site 367928000537 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 367928000538 active site 367928000539 KMSKS motif; other site 367928000540 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 367928000541 putative active site [active] 367928000542 putative metal binding site [ion binding]; other site 367928000543 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 367928000544 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 367928000545 Transcriptional regulator [Transcription]; Region: IclR; COG1414 367928000546 Bacterial transcriptional regulator; Region: IclR; pfam01614 367928000547 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 367928000548 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 367928000549 substrate binding site [chemical binding]; other site 367928000550 ligand binding site [chemical binding]; other site 367928000551 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 367928000552 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 367928000553 substrate binding site [chemical binding]; other site 367928000554 Divergent AAA domain; Region: AAA_4; pfam04326 367928000555 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 367928000556 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 367928000557 active site 367928000558 FMN binding site [chemical binding]; other site 367928000559 substrate binding site [chemical binding]; other site 367928000560 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 367928000561 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 367928000562 hinge; other site 367928000563 active site 367928000564 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 367928000565 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 367928000566 putative acyl-acceptor binding pocket; other site 367928000567 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 367928000568 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 367928000569 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 367928000570 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 367928000571 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 367928000572 ATP-grasp domain; Region: ATP-grasp_4; cl17255 367928000573 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 367928000574 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 367928000575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 367928000576 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928000577 dimer interface [polypeptide binding]; other site 367928000578 conserved gate region; other site 367928000579 putative PBP binding loops; other site 367928000580 ABC-ATPase subunit interface; other site 367928000581 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 367928000582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928000583 Walker A/P-loop; other site 367928000584 ATP binding site [chemical binding]; other site 367928000585 Q-loop/lid; other site 367928000586 ABC transporter signature motif; other site 367928000587 Walker B; other site 367928000588 D-loop; other site 367928000589 H-loop/switch region; other site 367928000590 TOBE domain; Region: TOBE_2; pfam08402 367928000591 CAAX protease self-immunity; Region: Abi; pfam02517 367928000592 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 367928000593 Mechanosensitive ion channel; Region: MS_channel; pfam00924 367928000594 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 367928000595 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 367928000596 nucleophilic elbow; other site 367928000597 catalytic triad; other site 367928000598 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367928000599 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928000600 aspartate aminotransferase; Provisional; Region: PRK06836 367928000601 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928000602 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928000603 homodimer interface [polypeptide binding]; other site 367928000604 catalytic residue [active] 367928000605 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 367928000606 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 367928000607 fructuronate transporter; Provisional; Region: PRK10034; cl15264 367928000608 GntP family permease; Region: GntP_permease; pfam02447 367928000609 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 367928000610 AAA domain; Region: AAA_33; pfam13671 367928000611 ATP-binding site [chemical binding]; other site 367928000612 Gluconate-6-phosphate binding site [chemical binding]; other site 367928000613 Transcriptional regulators [Transcription]; Region: FadR; COG2186 367928000614 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 367928000615 DNA-binding site [nucleotide binding]; DNA binding site 367928000616 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 367928000617 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 367928000618 active site 367928000619 NTP binding site [chemical binding]; other site 367928000620 metal binding triad [ion binding]; metal-binding site 367928000621 Vacuole effluxer Atg22 like; Region: ATG22; pfam11700 367928000622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928000623 putative substrate translocation pore; other site 367928000624 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 367928000625 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 367928000626 ssDNA binding site; other site 367928000627 generic binding surface II; other site 367928000628 DEAD-like helicases superfamily; Region: DEXDc; smart00487 367928000629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928000630 ATP binding site [chemical binding]; other site 367928000631 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928000632 putative Mg++ binding site [ion binding]; other site 367928000633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928000634 nucleotide binding region [chemical binding]; other site 367928000635 ATP-binding site [chemical binding]; other site 367928000636 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 367928000637 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 367928000638 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 367928000639 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 367928000640 RimM N-terminal domain; Region: RimM; pfam01782 367928000641 hypothetical protein; Provisional; Region: PRK02821 367928000642 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 367928000643 G-X-X-G motif; other site 367928000644 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 367928000645 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 367928000646 putative catalytic site [active] 367928000647 putative metal binding site [ion binding]; other site 367928000648 putative phosphate binding site [ion binding]; other site 367928000649 signal recognition particle protein; Provisional; Region: PRK10867 367928000650 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 367928000651 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 367928000652 P loop; other site 367928000653 GTP binding site [chemical binding]; other site 367928000654 Signal peptide binding domain; Region: SRP_SPB; pfam02978 367928000655 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 367928000656 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367928000657 active site 367928000658 HIGH motif; other site 367928000659 nucleotide binding site [chemical binding]; other site 367928000660 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 367928000661 KMSKS motif; other site 367928000662 This DALR domain is found in cysteinyl-tRNA-synthetases; Region: DALR_2; smart00840 367928000663 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 367928000664 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 367928000665 catalytic triad [active] 367928000666 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928000667 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367928000668 ABC transporter; Region: ABC_tran_2; pfam12848 367928000669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367928000670 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928000671 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 367928000672 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 367928000673 ATP binding site [chemical binding]; other site 367928000674 Mg2+ binding site [ion binding]; other site 367928000675 G-X-G motif; other site 367928000676 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 367928000677 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928000678 active site 367928000679 phosphorylation site [posttranslational modification] 367928000680 intermolecular recognition site; other site 367928000681 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 367928000682 DNA binding residues [nucleotide binding] 367928000683 dimerization interface [polypeptide binding]; other site 367928000684 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367928000685 dimerization interface [polypeptide binding]; other site 367928000686 putative DNA binding site [nucleotide binding]; other site 367928000687 Transcriptional regulators [Transcription]; Region: MarR; COG1846 367928000688 putative Zn2+ binding site [ion binding]; other site 367928000689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928000690 putative substrate translocation pore; other site 367928000691 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 367928000692 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 367928000693 putative valine binding site [chemical binding]; other site 367928000694 dimer interface [polypeptide binding]; other site 367928000695 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 367928000696 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 367928000697 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 367928000698 PYR/PP interface [polypeptide binding]; other site 367928000699 dimer interface [polypeptide binding]; other site 367928000700 TPP binding site [chemical binding]; other site 367928000701 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 367928000702 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 367928000703 TPP-binding site [chemical binding]; other site 367928000704 dimer interface [polypeptide binding]; other site 367928000705 ribonuclease III; Reviewed; Region: rnc; PRK00102 367928000706 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 367928000707 dimerization interface [polypeptide binding]; other site 367928000708 active site 367928000709 metal binding site [ion binding]; metal-binding site 367928000710 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cl00054 367928000711 dsRNA binding site [nucleotide binding]; other site 367928000712 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 367928000713 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 367928000714 F0F1 ATP synthase subunit B'; Validated; Region: PRK07353 367928000715 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 367928000716 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 367928000717 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 367928000718 active site 367928000719 Membrane transport protein; Region: Mem_trans; cl09117 367928000720 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 367928000721 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 367928000722 active site 367928000723 dimer interface [polypeptide binding]; other site 367928000724 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 367928000725 dimer interface [polypeptide binding]; other site 367928000726 active site 367928000727 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 367928000728 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 367928000729 RNA/DNA hybrid binding site [nucleotide binding]; other site 367928000730 active site 367928000731 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 367928000732 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367928000733 Walker A/P-loop; other site 367928000734 ATP binding site [chemical binding]; other site 367928000735 Q-loop/lid; other site 367928000736 ABC transporter signature motif; other site 367928000737 Walker B; other site 367928000738 D-loop; other site 367928000739 H-loop/switch region; other site 367928000740 Predicted permeases [General function prediction only]; Region: COG0679 367928000741 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 367928000742 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 367928000743 metal binding site [ion binding]; metal-binding site 367928000744 putative dimer interface [polypeptide binding]; other site 367928000745 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 367928000746 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 367928000747 homodimer interface [polypeptide binding]; other site 367928000748 oligonucleotide binding site [chemical binding]; other site 367928000749 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 367928000750 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 367928000751 GTPase CgtA; Reviewed; Region: obgE; PRK12296 367928000752 GTP1/OBG; Region: GTP1_OBG; pfam01018 367928000753 Obg GTPase; Region: Obg; cd01898 367928000754 G1 box; other site 367928000755 GTP/Mg2+ binding site [chemical binding]; other site 367928000756 Switch I region; other site 367928000757 G2 box; other site 367928000758 G3 box; other site 367928000759 Switch II region; other site 367928000760 G4 box; other site 367928000761 G5 box; other site 367928000762 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 367928000763 gamma-glutamyl kinase; Provisional; Region: PRK05429 367928000764 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 367928000765 nucleotide binding site [chemical binding]; other site 367928000766 homotetrameric interface [polypeptide binding]; other site 367928000767 putative phosphate binding site [ion binding]; other site 367928000768 putative allosteric binding site; other site 367928000769 PUA domain; Region: PUA; pfam01472 367928000770 aspartate aminotransferase; Provisional; Region: PRK05764 367928000771 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928000772 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928000773 homodimer interface [polypeptide binding]; other site 367928000774 catalytic residue [active] 367928000775 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 367928000776 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 367928000777 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 367928000778 putative homodimer interface [polypeptide binding]; other site 367928000779 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 367928000780 heterodimer interface [polypeptide binding]; other site 367928000781 homodimer interface [polypeptide binding]; other site 367928000782 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 367928000783 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 367928000784 23S rRNA interface [nucleotide binding]; other site 367928000785 L7/L12 interface [polypeptide binding]; other site 367928000786 putative thiostrepton binding site; other site 367928000787 L25 interface [polypeptide binding]; other site 367928000788 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 367928000789 mRNA/rRNA interface [nucleotide binding]; other site 367928000790 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 367928000791 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 367928000792 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 367928000793 BioY family; Region: BioY; pfam02632 367928000794 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 367928000795 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 367928000796 ATP-grasp domain; Region: ATP-grasp_4; cl17255 367928000797 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 367928000798 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 367928000799 carboxyltransferase (CT) interaction site; other site 367928000800 biotinylation site [posttranslational modification]; other site 367928000801 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 367928000802 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 367928000803 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 367928000804 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 367928000805 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 367928000806 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 367928000807 phosphate binding site [ion binding]; other site 367928000808 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 367928000809 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 367928000810 putative active site [active] 367928000811 putative catalytic site [active] 367928000812 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 367928000813 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 367928000814 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 367928000815 putative NAD(P) binding site [chemical binding]; other site 367928000816 active site 367928000817 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 367928000818 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 367928000819 active site 367928000820 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 367928000821 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 367928000822 16S/18S rRNA binding site [nucleotide binding]; other site 367928000823 S13e-L30e interaction site [polypeptide binding]; other site 367928000824 25S rRNA binding site [nucleotide binding]; other site 367928000825 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 367928000826 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 367928000827 oligomer interface [polypeptide binding]; other site 367928000828 RNA binding site [nucleotide binding]; other site 367928000829 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 367928000830 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 367928000831 RNase E interface [polypeptide binding]; other site 367928000832 trimer interface [polypeptide binding]; other site 367928000833 active site 367928000834 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 367928000835 putative nucleic acid binding region [nucleotide binding]; other site 367928000836 G-X-X-G motif; other site 367928000837 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 367928000838 RNA binding site [nucleotide binding]; other site 367928000839 domain interface; other site 367928000840 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 367928000841 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 367928000842 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 367928000843 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 367928000844 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 367928000845 active site 367928000846 catalytic tetrad [active] 367928000847 LysE type translocator; Region: LysE; cl00565 367928000848 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 367928000849 DNA-binding site [nucleotide binding]; DNA binding site 367928000850 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 367928000851 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928000852 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928000853 homodimer interface [polypeptide binding]; other site 367928000854 catalytic residue [active] 367928000855 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 367928000856 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 367928000857 Peptidase family U32; Region: Peptidase_U32; pfam01136 367928000858 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 367928000859 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 367928000860 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 367928000861 substrate binding site; other site 367928000862 dimer interface; other site 367928000863 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 367928000864 putative substrate binding pocket [chemical binding]; other site 367928000865 AC domain interface; other site 367928000866 catalytic triad [active] 367928000867 AB domain interface; other site 367928000868 interchain disulfide; other site 367928000869 DivIVA protein; Region: DivIVA; pfam05103 367928000870 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 367928000871 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 367928000872 trimer interface [polypeptide binding]; other site 367928000873 active site 367928000874 G bulge; other site 367928000875 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 367928000876 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 367928000877 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 367928000878 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 367928000879 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 367928000880 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 367928000881 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 367928000882 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367928000883 dimer interface [polypeptide binding]; other site 367928000884 phosphorylation site [posttranslational modification] 367928000885 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928000886 ATP binding site [chemical binding]; other site 367928000887 Mg2+ binding site [ion binding]; other site 367928000888 G-X-G motif; other site 367928000889 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367928000890 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928000891 active site 367928000892 phosphorylation site [posttranslational modification] 367928000893 intermolecular recognition site; other site 367928000894 dimerization interface [polypeptide binding]; other site 367928000895 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367928000896 DNA binding site [nucleotide binding] 367928000897 PBP superfamily domain; Region: PBP_like_2; cl17296 367928000898 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 367928000899 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928000900 dimer interface [polypeptide binding]; other site 367928000901 conserved gate region; other site 367928000902 putative PBP binding loops; other site 367928000903 ABC-ATPase subunit interface; other site 367928000904 sulfate transport protein; Provisional; Region: cysT; CHL00187 367928000905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928000906 dimer interface [polypeptide binding]; other site 367928000907 conserved gate region; other site 367928000908 putative PBP binding loops; other site 367928000909 ABC-ATPase subunit interface; other site 367928000910 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 367928000911 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 367928000912 Walker A/P-loop; other site 367928000913 ATP binding site [chemical binding]; other site 367928000914 Q-loop/lid; other site 367928000915 ABC transporter signature motif; other site 367928000916 Walker B; other site 367928000917 D-loop; other site 367928000918 H-loop/switch region; other site 367928000919 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 367928000920 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 367928000921 intersubunit interface [polypeptide binding]; other site 367928000922 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 367928000923 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 367928000924 23S rRNA interface [nucleotide binding]; other site 367928000925 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 367928000926 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 367928000927 peripheral dimer interface [polypeptide binding]; other site 367928000928 core dimer interface [polypeptide binding]; other site 367928000929 L10 interface [polypeptide binding]; other site 367928000930 L11 interface [polypeptide binding]; other site 367928000931 putative EF-Tu interaction site [polypeptide binding]; other site 367928000932 putative EF-G interaction site [polypeptide binding]; other site 367928000933 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 367928000934 phosphopeptide binding site; other site 367928000935 Part of AAA domain; Region: AAA_19; pfam13245 367928000936 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 367928000937 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 367928000938 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 367928000939 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 367928000940 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 367928000941 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 367928000942 oligomerisation interface [polypeptide binding]; other site 367928000943 mobile loop; other site 367928000944 roof hairpin; other site 367928000945 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 367928000946 FAD binding domain; Region: FAD_binding_4; pfam01565 367928000947 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 367928000948 amino acid transporter; Region: 2A0306; TIGR00909 367928000949 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 367928000950 Ferredoxin [Energy production and conversion]; Region: COG1146 367928000951 4Fe-4S binding domain; Region: Fer4; pfam00037 367928000952 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 367928000953 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928000954 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928000955 homodimer interface [polypeptide binding]; other site 367928000956 catalytic residue [active] 367928000957 Right handed beta helix region; Region: Beta_helix; pfam13229 367928000958 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 367928000959 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 367928000960 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 367928000961 active site 367928000962 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 367928000963 Carboxylesterase family; Region: COesterase; pfam00135 367928000964 substrate binding pocket [chemical binding]; other site 367928000965 catalytic triad [active] 367928000966 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 367928000967 active site 367928000968 DNA polymerase IV; Validated; Region: PRK02406 367928000969 DNA binding site [nucleotide binding] 367928000970 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 367928000971 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 367928000972 putative active site [active] 367928000973 putative metal binding site [ion binding]; other site 367928000974 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 367928000975 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 367928000976 dimerization interface [polypeptide binding]; other site 367928000977 NAD binding site [chemical binding]; other site 367928000978 ligand binding site [chemical binding]; other site 367928000979 catalytic site [active] 367928000980 Uncharacterized conserved protein [Function unknown]; Region: COG1739 367928000981 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 367928000982 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 367928000983 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 367928000984 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 367928000985 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 367928000986 23S rRNA interface [nucleotide binding]; other site 367928000987 L3 interface [polypeptide binding]; other site 367928000988 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 367928000989 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 367928000990 active site 367928000991 catalytic site [active] 367928000992 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 367928000993 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 367928000994 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 367928000995 putative NAD(P) binding site [chemical binding]; other site 367928000996 catalytic Zn binding site [ion binding]; other site 367928000997 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 367928000998 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 367928000999 active site 367928001000 metal binding site [ion binding]; metal-binding site 367928001001 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 367928001002 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 367928001003 polyol permease family; Region: 2A0118; TIGR00897 367928001004 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928001005 putative substrate translocation pore; other site 367928001006 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 367928001007 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 367928001008 inhibitor binding site; inhibition site 367928001009 catalytic Zn binding site [ion binding]; other site 367928001010 structural Zn binding site [ion binding]; other site 367928001011 NADP binding site [chemical binding]; other site 367928001012 tetramer interface [polypeptide binding]; other site 367928001013 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 367928001014 Helix-turn-helix domain; Region: HTH_18; pfam12833 367928001015 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367928001016 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 367928001017 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 367928001018 putative catalytic cysteine [active] 367928001019 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 367928001020 putative active site [active] 367928001021 metal binding site [ion binding]; metal-binding site 367928001022 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 367928001023 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 367928001024 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 367928001025 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 367928001026 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 367928001027 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 367928001028 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 367928001029 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 367928001030 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 367928001031 putative translocon binding site; other site 367928001032 protein-rRNA interface [nucleotide binding]; other site 367928001033 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 367928001034 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 367928001035 G-X-X-G motif; other site 367928001036 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 367928001037 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 367928001038 23S rRNA interface [nucleotide binding]; other site 367928001039 5S rRNA interface [nucleotide binding]; other site 367928001040 putative antibiotic binding site [chemical binding]; other site 367928001041 L25 interface [polypeptide binding]; other site 367928001042 L27 interface [polypeptide binding]; other site 367928001043 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 367928001044 23S rRNA interface [nucleotide binding]; other site 367928001045 putative translocon interaction site; other site 367928001046 signal recognition particle (SRP54) interaction site; other site 367928001047 L23 interface [polypeptide binding]; other site 367928001048 trigger factor interaction site; other site 367928001049 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 367928001050 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 367928001051 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 367928001052 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 367928001053 RNA binding site [nucleotide binding]; other site 367928001054 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 367928001055 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 367928001056 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 367928001057 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 367928001058 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 367928001059 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 367928001060 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 367928001061 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 367928001062 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 367928001063 5S rRNA interface [nucleotide binding]; other site 367928001064 L27 interface [polypeptide binding]; other site 367928001065 23S rRNA interface [nucleotide binding]; other site 367928001066 L5 interface [polypeptide binding]; other site 367928001067 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 367928001068 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 367928001069 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 367928001070 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 367928001071 23S rRNA binding site [nucleotide binding]; other site 367928001072 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 367928001073 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 367928001074 SecY translocase; Region: SecY; pfam00344 367928001075 adenylate kinase; Reviewed; Region: adk; PRK00279 367928001076 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 367928001077 AMP-binding site [chemical binding]; other site 367928001078 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 367928001079 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 367928001080 rRNA binding site [nucleotide binding]; other site 367928001081 predicted 30S ribosome binding site; other site 367928001082 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 367928001083 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 367928001084 30S ribosomal protein S13; Region: bact_S13; TIGR03631 367928001085 30S ribosomal protein S11; Validated; Region: PRK05309 367928001086 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 367928001087 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 367928001088 alphaNTD homodimer interface [polypeptide binding]; other site 367928001089 alphaNTD - beta interaction site [polypeptide binding]; other site 367928001090 alphaNTD - beta' interaction site [polypeptide binding]; other site 367928001091 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 367928001092 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 367928001093 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 367928001094 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 367928001095 dimerization interface 3.5A [polypeptide binding]; other site 367928001096 active site 367928001097 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 367928001098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 367928001099 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 367928001100 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 367928001101 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 367928001102 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 367928001103 NusA N-terminal domain; Region: NusA_N; pfam08529 367928001104 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 367928001105 RNA binding site [nucleotide binding]; other site 367928001106 homodimer interface [polypeptide binding]; other site 367928001107 NusA-like KH domain; Region: KH_5; pfam13184 367928001108 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 367928001109 G-X-X-G motif; other site 367928001110 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 367928001111 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 367928001112 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 367928001113 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 367928001114 G1 box; other site 367928001115 putative GEF interaction site [polypeptide binding]; other site 367928001116 GTP/Mg2+ binding site [chemical binding]; other site 367928001117 Switch I region; other site 367928001118 G2 box; other site 367928001119 G3 box; other site 367928001120 Switch II region; other site 367928001121 G4 box; other site 367928001122 G5 box; other site 367928001123 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 367928001124 Translation-initiation factor 2; Region: IF-2; pfam11987 367928001125 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 367928001126 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 367928001127 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 367928001128 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 367928001129 RNA binding site [nucleotide binding]; other site 367928001130 active site 367928001131 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 367928001132 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 367928001133 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 367928001134 active site 367928001135 Riboflavin kinase; Region: Flavokinase; smart00904 367928001136 DNA repair protein RadA; Provisional; Region: PRK11823 367928001137 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 367928001138 Walker A motif; other site 367928001139 ATP binding site [chemical binding]; other site 367928001140 Walker B motif; other site 367928001141 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 367928001142 tetramer (dimer of dimers) interface [polypeptide binding]; other site 367928001143 active site 367928001144 dimer interface [polypeptide binding]; other site 367928001145 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 367928001146 RNA/DNA hybrid binding site [nucleotide binding]; other site 367928001147 active site 367928001148 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928001149 ATP binding site [chemical binding]; other site 367928001150 Mg2+ binding site [ion binding]; other site 367928001151 G-X-G motif; other site 367928001152 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 367928001153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928001154 active site 367928001155 dimerization interface [polypeptide binding]; other site 367928001156 LytTr DNA-binding domain; Region: LytTR; smart00850 367928001157 phosphoglucomutase; Validated; Region: PRK07564 367928001158 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 367928001159 active site 367928001160 substrate binding site [chemical binding]; other site 367928001161 metal binding site [ion binding]; metal-binding site 367928001162 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 367928001163 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 367928001164 active site turn [active] 367928001165 phosphorylation site [posttranslational modification] 367928001166 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 367928001167 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 367928001168 HPr interaction site; other site 367928001169 glycerol kinase (GK) interaction site [polypeptide binding]; other site 367928001170 active site 367928001171 phosphorylation site [posttranslational modification] 367928001172 transcriptional antiterminator BglG; Provisional; Region: PRK09772 367928001173 CAT RNA binding domain; Region: CAT_RBD; smart01061 367928001174 PRD domain; Region: PRD; pfam00874 367928001175 PRD domain; Region: PRD; pfam00874 367928001176 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 367928001177 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 367928001178 seryl-tRNA synthetase; Provisional; Region: PRK05431 367928001179 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 367928001180 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 367928001181 dimer interface [polypeptide binding]; other site 367928001182 active site 367928001183 motif 1; other site 367928001184 motif 2; other site 367928001185 motif 3; other site 367928001186 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 367928001187 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928001188 active site 367928001189 phosphorylation site [posttranslational modification] 367928001190 intermolecular recognition site; other site 367928001191 dimerization interface [polypeptide binding]; other site 367928001192 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 367928001193 DNA binding residues [nucleotide binding] 367928001194 dimerization interface [polypeptide binding]; other site 367928001195 PspC domain; Region: PspC; cl00864 367928001196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 367928001197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928001198 ATP binding site [chemical binding]; other site 367928001199 Mg2+ binding site [ion binding]; other site 367928001200 G-X-G motif; other site 367928001201 PspC domain; Region: PspC; pfam04024 367928001202 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 367928001203 MFS transport protein AraJ; Provisional; Region: PRK10091 367928001204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928001205 putative substrate translocation pore; other site 367928001206 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 367928001207 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 367928001208 dimer interface [polypeptide binding]; other site 367928001209 putative anticodon binding site; other site 367928001210 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 367928001211 motif 1; other site 367928001212 dimer interface [polypeptide binding]; other site 367928001213 active site 367928001214 motif 2; other site 367928001215 motif 3; other site 367928001216 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 367928001217 UbiA prenyltransferase family; Region: UbiA; pfam01040 367928001218 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928001219 catalytic core [active] 367928001220 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 367928001221 myosin-cross-reactive antigen; Provisional; Region: PRK13977 367928001222 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 367928001223 PhoU domain; Region: PhoU; pfam01895 367928001224 PhoU domain; Region: PhoU; pfam01895 367928001225 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 367928001226 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928001227 ATP binding site [chemical binding]; other site 367928001228 Mg2+ binding site [ion binding]; other site 367928001229 G-X-G motif; other site 367928001230 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 367928001231 phosphoserine aminotransferase; Provisional; Region: PRK03080 367928001232 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367928001233 catalytic residue [active] 367928001234 CHAP domain; Region: CHAP; pfam05257 367928001235 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 367928001236 NlpC/P60 family; Region: NLPC_P60; pfam00877 367928001237 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 367928001238 Ligand Binding Site [chemical binding]; other site 367928001239 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 367928001240 Ligand Binding Site [chemical binding]; other site 367928001241 OsmC-like protein; Region: OsmC; pfam02566 367928001242 thymidylate synthase; Reviewed; Region: thyA; PRK01827 367928001243 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 367928001244 dimerization interface [polypeptide binding]; other site 367928001245 active site 367928001246 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 367928001247 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 367928001248 folate binding site [chemical binding]; other site 367928001249 NADP+ binding site [chemical binding]; other site 367928001250 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 367928001251 Low molecular weight phosphatase family; Region: LMWPc; cd00115 367928001252 active site 367928001253 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 367928001254 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 367928001255 NAD(P) binding site [chemical binding]; other site 367928001256 active site 367928001257 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 367928001258 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 367928001259 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 367928001260 active site 367928001261 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 367928001262 GAF domain; Region: GAF_3; pfam13492 367928001263 Uncharacterized protein conserved in bacteria (DUF2194); Region: DUF2194; pfam09960 367928001264 Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924 367928001265 NodB motif; other site 367928001266 putative active site [active] 367928001267 putative catalytic site [active] 367928001268 putative Zn binding site [ion binding]; other site 367928001269 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 367928001270 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367928001271 Predicted membrane protein [Function unknown]; Region: COG4267 367928001272 CotH protein; Region: CotH; pfam08757 367928001273 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 367928001274 putative metal binding residues [ion binding]; other site 367928001275 signature motif; other site 367928001276 dimer interface [polypeptide binding]; other site 367928001277 active site 367928001278 polyP binding site; other site 367928001279 substrate binding site [chemical binding]; other site 367928001280 acceptor-phosphate pocket; other site 367928001281 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 367928001282 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 367928001283 dimer interface [polypeptide binding]; other site 367928001284 active site 367928001285 metal binding site [ion binding]; metal-binding site 367928001286 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 367928001287 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 367928001288 active site 367928001289 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 367928001290 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 367928001291 Domain of unknown function DUF20; Region: UPF0118; pfam01594 367928001292 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 367928001293 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 367928001294 DXD motif; other site 367928001295 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 367928001296 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 367928001297 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367928001298 active site 367928001299 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 367928001300 Preprotein translocase subunit; Region: YajC; cl00806 367928001301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928001302 Walker A motif; other site 367928001303 ATP binding site [chemical binding]; other site 367928001304 Walker B motif; other site 367928001305 arginine finger; other site 367928001306 Peptidase family M41; Region: Peptidase_M41; pfam01434 367928001307 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 367928001308 GTP cyclohydrolase I; Provisional; Region: PLN03044 367928001309 active site 367928001310 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 367928001311 dihydropteroate synthase; Region: DHPS; TIGR01496 367928001312 substrate binding pocket [chemical binding]; other site 367928001313 dimer interface [polypeptide binding]; other site 367928001314 inhibitor binding site; inhibition site 367928001315 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 367928001316 homooctamer interface [polypeptide binding]; other site 367928001317 active site 367928001318 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 367928001319 catalytic center binding site [active] 367928001320 ATP binding site [chemical binding]; other site 367928001321 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 367928001322 catalytic center binding site [active] 367928001323 ATP binding site [chemical binding]; other site 367928001324 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 367928001325 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 367928001326 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 367928001327 active site 367928001328 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 367928001329 catalytic triad [active] 367928001330 dimer interface [polypeptide binding]; other site 367928001331 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 367928001332 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928001333 Walker A/P-loop; other site 367928001334 ATP binding site [chemical binding]; other site 367928001335 Q-loop/lid; other site 367928001336 ABC transporter signature motif; other site 367928001337 Walker B; other site 367928001338 D-loop; other site 367928001339 H-loop/switch region; other site 367928001340 ABC transporter; Region: ABC_tran_2; pfam12848 367928001341 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367928001342 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 367928001343 catalytic motif [active] 367928001344 Zn binding site [ion binding]; other site 367928001345 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 367928001346 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 367928001347 active site 367928001348 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 367928001349 putative active site [active] 367928001350 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 367928001351 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 367928001352 homodimer interface [polypeptide binding]; other site 367928001353 substrate-cofactor binding pocket; other site 367928001354 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928001355 catalytic residue [active] 367928001356 xylose isomerase; Provisional; Region: PRK05474 367928001357 xylose isomerase; Region: xylose_isom_A; TIGR02630 367928001358 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 367928001359 active site 367928001360 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928001361 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928001362 DNA binding site [nucleotide binding] 367928001363 domain linker motif; other site 367928001364 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 367928001365 putative dimerization interface [polypeptide binding]; other site 367928001366 putative ligand binding site [chemical binding]; other site 367928001367 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 367928001368 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 367928001369 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 367928001370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928001371 dimer interface [polypeptide binding]; other site 367928001372 conserved gate region; other site 367928001373 putative PBP binding loops; other site 367928001374 ABC-ATPase subunit interface; other site 367928001375 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 367928001376 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928001377 dimer interface [polypeptide binding]; other site 367928001378 conserved gate region; other site 367928001379 putative PBP binding loops; other site 367928001380 ABC-ATPase subunit interface; other site 367928001381 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 367928001382 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 367928001383 inhibitor binding site; inhibition site 367928001384 active site 367928001385 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 367928001386 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 367928001387 Domain of unknown function (DUF303); Region: DUF303; pfam03629 367928001388 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 367928001389 Domain of unknown function (DUF303); Region: DUF303; pfam03629 367928001390 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 367928001391 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 367928001392 substrate binding pocket [chemical binding]; other site 367928001393 catalytic triad [active] 367928001394 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 367928001395 trimer interface [polypeptide binding]; other site 367928001396 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 367928001397 active site 367928001398 substrate binding site [chemical binding]; other site 367928001399 CoA binding site [chemical binding]; other site 367928001400 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 367928001401 N- and C-terminal domain interface [polypeptide binding]; other site 367928001402 D-xylulose kinase; Region: XylB; TIGR01312 367928001403 active site 367928001404 MgATP binding site [chemical binding]; other site 367928001405 catalytic site [active] 367928001406 metal binding site [ion binding]; metal-binding site 367928001407 xylulose binding site [chemical binding]; other site 367928001408 putative homodimer interface [polypeptide binding]; other site 367928001409 Transcriptional regulators [Transcription]; Region: MarR; COG1846 367928001410 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 367928001411 non-specific DNA interactions [nucleotide binding]; other site 367928001412 DNA binding site [nucleotide binding] 367928001413 sequence specific DNA binding site [nucleotide binding]; other site 367928001414 putative cAMP binding site [chemical binding]; other site 367928001415 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 367928001416 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 367928001417 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 367928001418 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 367928001419 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 367928001420 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 367928001421 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 367928001422 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 367928001423 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 367928001424 nucleotide binding site [chemical binding]; other site 367928001425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367928001426 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928001427 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 367928001428 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 367928001429 N-terminal domain of glycoside hydrolase family 94 and related domains; Region: GH94N_like; cl17067 367928001430 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 367928001431 peptide chain release factor 1; Validated; Region: prfA; PRK00591 367928001432 PCRF domain; Region: PCRF; pfam03462 367928001433 RF-1 domain; Region: RF-1; pfam00472 367928001434 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 367928001435 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367928001436 S-adenosylmethionine binding site [chemical binding]; other site 367928001437 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 367928001438 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 367928001439 putative ligand binding site [chemical binding]; other site 367928001440 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 367928001441 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 367928001442 TM-ABC transporter signature motif; other site 367928001443 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 367928001444 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 367928001445 TM-ABC transporter signature motif; other site 367928001446 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 367928001447 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 367928001448 Walker A/P-loop; other site 367928001449 ATP binding site [chemical binding]; other site 367928001450 Q-loop/lid; other site 367928001451 ABC transporter signature motif; other site 367928001452 Walker B; other site 367928001453 D-loop; other site 367928001454 H-loop/switch region; other site 367928001455 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 367928001456 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 367928001457 Walker A/P-loop; other site 367928001458 ATP binding site [chemical binding]; other site 367928001459 Q-loop/lid; other site 367928001460 ABC transporter signature motif; other site 367928001461 Walker B; other site 367928001462 D-loop; other site 367928001463 H-loop/switch region; other site 367928001464 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 367928001465 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 367928001466 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 367928001467 Mg++ binding site [ion binding]; other site 367928001468 putative catalytic motif [active] 367928001469 substrate binding site [chemical binding]; other site 367928001470 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 367928001471 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 367928001472 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 367928001473 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 367928001474 active site 367928001475 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928001476 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928001477 DNA binding site [nucleotide binding] 367928001478 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928001479 ligand binding site [chemical binding]; other site 367928001480 dimerization interface [polypeptide binding]; other site 367928001481 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 367928001482 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 367928001483 active site 367928001484 catalytic site [active] 367928001485 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 367928001486 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 367928001487 catalytic site [active] 367928001488 putative active site [active] 367928001489 putative substrate binding site [chemical binding]; other site 367928001490 dimer interface [polypeptide binding]; other site 367928001491 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928001492 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 367928001493 active site 367928001494 motif I; other site 367928001495 motif II; other site 367928001496 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 367928001497 AAA domain; Region: AAA_30; pfam13604 367928001498 PIF1-like helicase; Region: PIF1; pfam05970 367928001499 prolyl-tRNA synthetase; Provisional; Region: PRK09194 367928001500 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 367928001501 dimer interface [polypeptide binding]; other site 367928001502 motif 1; other site 367928001503 active site 367928001504 motif 2; other site 367928001505 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 367928001506 putative deacylase active site [active] 367928001507 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 367928001508 active site 367928001509 motif 3; other site 367928001510 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 367928001511 anticodon binding site; other site 367928001512 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 367928001513 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 367928001514 dimer interface [polypeptide binding]; other site 367928001515 ssDNA binding site [nucleotide binding]; other site 367928001516 tetramer (dimer of dimers) interface [polypeptide binding]; other site 367928001517 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 367928001518 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 367928001519 active site 367928001520 Zn binding site [ion binding]; other site 367928001521 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 367928001522 active site 367928001523 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 367928001524 Citrate synthase; Region: Citrate_synt; pfam00285 367928001525 oxalacetate binding site [chemical binding]; other site 367928001526 citrylCoA binding site [chemical binding]; other site 367928001527 coenzyme A binding site [chemical binding]; other site 367928001528 catalytic triad [active] 367928001529 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 367928001530 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 367928001531 putative trimer interface [polypeptide binding]; other site 367928001532 putative CoA binding site [chemical binding]; other site 367928001533 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 367928001534 peptide chain release factor 2; Validated; Region: prfB; PRK00578 367928001535 This domain is found in peptide chain release factors; Region: PCRF; smart00937 367928001536 RF-1 domain; Region: RF-1; pfam00472 367928001537 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 367928001538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928001539 Walker A/P-loop; other site 367928001540 ATP binding site [chemical binding]; other site 367928001541 Q-loop/lid; other site 367928001542 ABC transporter signature motif; other site 367928001543 Walker B; other site 367928001544 D-loop; other site 367928001545 H-loop/switch region; other site 367928001546 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 367928001547 FtsX-like permease family; Region: FtsX; pfam02687 367928001548 CHAP domain; Region: CHAP; pfam05257 367928001549 Surface antigen [General function prediction only]; Region: COG3942 367928001550 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 367928001551 SmpB-tmRNA interface; other site 367928001552 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367928001553 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367928001554 substrate binding pocket [chemical binding]; other site 367928001555 membrane-bound complex binding site; other site 367928001556 hinge residues; other site 367928001557 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367928001558 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367928001559 substrate binding pocket [chemical binding]; other site 367928001560 membrane-bound complex binding site; other site 367928001561 hinge residues; other site 367928001562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367928001563 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367928001564 substrate binding pocket [chemical binding]; other site 367928001565 membrane-bound complex binding site; other site 367928001566 hinge residues; other site 367928001567 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 367928001568 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928001569 dimer interface [polypeptide binding]; other site 367928001570 conserved gate region; other site 367928001571 putative PBP binding loops; other site 367928001572 ABC-ATPase subunit interface; other site 367928001573 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 367928001574 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 367928001575 Walker A/P-loop; other site 367928001576 ATP binding site [chemical binding]; other site 367928001577 Q-loop/lid; other site 367928001578 ABC transporter signature motif; other site 367928001579 Walker B; other site 367928001580 D-loop; other site 367928001581 H-loop/switch region; other site 367928001582 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 367928001583 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 367928001584 glutaminase active site [active] 367928001585 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 367928001586 dimer interface [polypeptide binding]; other site 367928001587 active site 367928001588 YtxH-like protein; Region: YtxH; pfam12732 367928001589 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 367928001590 dimer interface [polypeptide binding]; other site 367928001591 active site 367928001592 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 367928001593 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 367928001594 active site 367928001595 serine/threonine transporter SstT; Provisional; Region: PRK13628 367928001596 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 367928001597 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 367928001598 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 367928001599 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 367928001600 pantothenate kinase; Reviewed; Region: PRK13318 367928001601 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 367928001602 Flavoprotein; Region: Flavoprotein; pfam02441 367928001603 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 367928001604 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 367928001605 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 367928001606 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 367928001607 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 367928001608 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 367928001609 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 367928001610 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 367928001611 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 367928001612 Walker A/P-loop; other site 367928001613 ATP binding site [chemical binding]; other site 367928001614 Q-loop/lid; other site 367928001615 ABC transporter signature motif; other site 367928001616 Walker B; other site 367928001617 D-loop; other site 367928001618 H-loop/switch region; other site 367928001619 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 367928001620 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 367928001621 Walker A/P-loop; other site 367928001622 ATP binding site [chemical binding]; other site 367928001623 Q-loop/lid; other site 367928001624 ABC transporter signature motif; other site 367928001625 Walker B; other site 367928001626 D-loop; other site 367928001627 H-loop/switch region; other site 367928001628 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928001629 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928001630 Walker A/P-loop; other site 367928001631 ATP binding site [chemical binding]; other site 367928001632 Q-loop/lid; other site 367928001633 ABC transporter signature motif; other site 367928001634 Walker B; other site 367928001635 D-loop; other site 367928001636 H-loop/switch region; other site 367928001637 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 367928001638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928001639 Walker A/P-loop; other site 367928001640 ATP binding site [chemical binding]; other site 367928001641 Q-loop/lid; other site 367928001642 ABC transporter signature motif; other site 367928001643 Walker B; other site 367928001644 D-loop; other site 367928001645 H-loop/switch region; other site 367928001646 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 367928001647 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 367928001648 dimer interface [polypeptide binding]; other site 367928001649 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928001650 catalytic residue [active] 367928001651 cystathionine gamma-synthase; Provisional; Region: PRK07811 367928001652 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 367928001653 homodimer interface [polypeptide binding]; other site 367928001654 substrate-cofactor binding pocket; other site 367928001655 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928001656 catalytic residue [active] 367928001657 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 367928001658 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928001659 ATP binding site [chemical binding]; other site 367928001660 putative Mg++ binding site [ion binding]; other site 367928001661 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928001662 nucleotide binding region [chemical binding]; other site 367928001663 ATP-binding site [chemical binding]; other site 367928001664 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 367928001665 HRDC domain; Region: HRDC; pfam00570 367928001666 S-ribosylhomocysteinase; Provisional; Region: PRK02260 367928001667 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 367928001668 amino acid transporter; Region: 2A0306; TIGR00909 367928001669 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 367928001670 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 367928001671 alanine racemase; Reviewed; Region: alr; PRK00053 367928001672 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 367928001673 active site 367928001674 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 367928001675 dimer interface [polypeptide binding]; other site 367928001676 substrate binding site [chemical binding]; other site 367928001677 catalytic residues [active] 367928001678 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 367928001679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367928001680 Zn2+ binding site [ion binding]; other site 367928001681 Mg2+ binding site [ion binding]; other site 367928001682 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 367928001683 DNA primase; Validated; Region: dnaG; PRK05667 367928001684 CHC2 zinc finger; Region: zf-CHC2; pfam01807 367928001685 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 367928001686 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 367928001687 active site 367928001688 metal binding site [ion binding]; metal-binding site 367928001689 interdomain interaction site; other site 367928001690 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 367928001691 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 367928001692 transmembrane helices; other site 367928001693 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 367928001694 Protein of unknown function, DUF606; Region: DUF606; pfam04657 367928001695 Protein of unknown function, DUF606; Region: DUF606; pfam04657 367928001696 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 367928001697 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 367928001698 G1 box; other site 367928001699 putative GEF interaction site [polypeptide binding]; other site 367928001700 GTP/Mg2+ binding site [chemical binding]; other site 367928001701 Switch I region; other site 367928001702 G2 box; other site 367928001703 G3 box; other site 367928001704 Switch II region; other site 367928001705 G4 box; other site 367928001706 G5 box; other site 367928001707 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 367928001708 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 367928001709 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 367928001710 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 367928001711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 367928001712 Coenzyme A binding pocket [chemical binding]; other site 367928001713 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 367928001714 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928001715 dimer interface [polypeptide binding]; other site 367928001716 conserved gate region; other site 367928001717 putative PBP binding loops; other site 367928001718 ABC-ATPase subunit interface; other site 367928001719 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 367928001720 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928001721 dimer interface [polypeptide binding]; other site 367928001722 conserved gate region; other site 367928001723 putative PBP binding loops; other site 367928001724 ABC-ATPase subunit interface; other site 367928001725 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 367928001726 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 367928001727 Walker A/P-loop; other site 367928001728 ATP binding site [chemical binding]; other site 367928001729 Q-loop/lid; other site 367928001730 ABC transporter signature motif; other site 367928001731 Walker B; other site 367928001732 D-loop; other site 367928001733 H-loop/switch region; other site 367928001734 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 367928001735 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367928001736 substrate binding pocket [chemical binding]; other site 367928001737 membrane-bound complex binding site; other site 367928001738 hinge residues; other site 367928001739 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 367928001740 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 367928001741 homodimer interface [polypeptide binding]; other site 367928001742 substrate-cofactor binding pocket; other site 367928001743 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928001744 catalytic residue [active] 367928001745 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 367928001746 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 367928001747 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928001748 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367928001749 Walker A/P-loop; other site 367928001750 ATP binding site [chemical binding]; other site 367928001751 Q-loop/lid; other site 367928001752 ABC transporter signature motif; other site 367928001753 Walker B; other site 367928001754 D-loop; other site 367928001755 H-loop/switch region; other site 367928001756 CARDB; Region: CARDB; pfam07705 367928001757 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928001758 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 367928001759 FtsX-like permease family; Region: FtsX; pfam02687 367928001760 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 367928001761 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 367928001762 TPP-binding site; other site 367928001763 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 367928001764 PYR/PP interface [polypeptide binding]; other site 367928001765 dimer interface [polypeptide binding]; other site 367928001766 TPP binding site [chemical binding]; other site 367928001767 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 367928001768 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 367928001769 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 367928001770 NAD(P) binding site [chemical binding]; other site 367928001771 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 367928001772 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 367928001773 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 367928001774 NAD binding site [chemical binding]; other site 367928001775 ATP-grasp domain; Region: ATP-grasp; pfam02222 367928001776 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 367928001777 metal binding site 2 [ion binding]; metal-binding site 367928001778 putative DNA binding helix; other site 367928001779 metal binding site 1 [ion binding]; metal-binding site 367928001780 dimer interface [polypeptide binding]; other site 367928001781 structural Zn2+ binding site [ion binding]; other site 367928001782 Sulfatase; Region: Sulfatase; pfam00884 367928001783 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 367928001784 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 367928001785 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 367928001786 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 367928001787 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 367928001788 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 367928001789 dimerization interface [polypeptide binding]; other site 367928001790 putative ATP binding site [chemical binding]; other site 367928001791 amidophosphoribosyltransferase; Provisional; Region: PRK07272 367928001792 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 367928001793 active site 367928001794 tetramer interface [polypeptide binding]; other site 367928001795 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367928001796 active site 367928001797 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 367928001798 Y-family of DNA polymerases; Region: PolY; cl12025 367928001799 active site 367928001800 DNA binding site [nucleotide binding] 367928001801 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 367928001802 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 367928001803 dimerization interface [polypeptide binding]; other site 367928001804 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 367928001805 dimerization interface [polypeptide binding]; other site 367928001806 ATP binding site [chemical binding]; other site 367928001807 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 367928001808 dimerization interface [polypeptide binding]; other site 367928001809 ATP binding site [chemical binding]; other site 367928001810 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 367928001811 putative active site [active] 367928001812 catalytic triad [active] 367928001813 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 367928001814 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 367928001815 ATP binding site [chemical binding]; other site 367928001816 active site 367928001817 substrate binding site [chemical binding]; other site 367928001818 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 367928001819 ATP-grasp domain; Region: ATP-grasp; pfam02222 367928001820 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 367928001821 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367928001822 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 367928001823 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 367928001824 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367928001825 catalytic residue [active] 367928001826 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 367928001827 Sodium Bile acid symporter family; Region: SBF; pfam01758 367928001828 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 367928001829 S17 interaction site [polypeptide binding]; other site 367928001830 S8 interaction site; other site 367928001831 16S rRNA interaction site [nucleotide binding]; other site 367928001832 streptomycin interaction site [chemical binding]; other site 367928001833 23S rRNA interaction site [nucleotide binding]; other site 367928001834 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 367928001835 30S ribosomal protein S7; Validated; Region: PRK05302 367928001836 elongation factor G; Reviewed; Region: PRK00007 367928001837 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 367928001838 G1 box; other site 367928001839 putative GEF interaction site [polypeptide binding]; other site 367928001840 GTP/Mg2+ binding site [chemical binding]; other site 367928001841 Switch I region; other site 367928001842 G2 box; other site 367928001843 G3 box; other site 367928001844 Switch II region; other site 367928001845 G4 box; other site 367928001846 G5 box; other site 367928001847 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 367928001848 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 367928001849 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 367928001850 elongation factor Tu; Reviewed; Region: PRK00049 367928001851 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 367928001852 G1 box; other site 367928001853 GEF interaction site [polypeptide binding]; other site 367928001854 GTP/Mg2+ binding site [chemical binding]; other site 367928001855 Switch I region; other site 367928001856 G2 box; other site 367928001857 G3 box; other site 367928001858 Switch II region; other site 367928001859 G4 box; other site 367928001860 G5 box; other site 367928001861 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 367928001862 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 367928001863 Antibiotic Binding Site [chemical binding]; other site 367928001864 elongation factor P; Validated; Region: PRK00529 367928001865 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 367928001866 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 367928001867 RNA binding site [nucleotide binding]; other site 367928001868 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 367928001869 RNA binding site [nucleotide binding]; other site 367928001870 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 367928001871 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 367928001872 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 367928001873 catalytic site [active] 367928001874 subunit interface [polypeptide binding]; other site 367928001875 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 367928001876 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 367928001877 ATP-grasp domain; Region: ATP-grasp_4; cl17255 367928001878 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 367928001879 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 367928001880 ATP-grasp domain; Region: ATP-grasp_4; cl17255 367928001881 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 367928001882 IMP binding site; other site 367928001883 dimer interface [polypeptide binding]; other site 367928001884 interdomain contacts; other site 367928001885 partial ornithine binding site; other site 367928001886 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 367928001887 active site 367928001888 dimer interface [polypeptide binding]; other site 367928001889 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 367928001890 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 367928001891 catalytic site [active] 367928001892 G-X2-G-X-G-K; other site 367928001893 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 367928001894 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 367928001895 S-adenosylmethionine synthetase; Validated; Region: PRK05250 367928001896 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 367928001897 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 367928001898 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 367928001899 primosome assembly protein PriA; Provisional; Region: PRK14873 367928001900 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 367928001901 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928001902 motif II; other site 367928001903 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 367928001904 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 367928001905 putative active site [active] 367928001906 substrate binding site [chemical binding]; other site 367928001907 putative cosubstrate binding site; other site 367928001908 catalytic site [active] 367928001909 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 367928001910 substrate binding site [chemical binding]; other site 367928001911 phosphoserine phosphatase SerB; Region: serB; TIGR00338 367928001912 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928001913 motif II; other site 367928001914 proteasome ATPase; Region: pup_AAA; TIGR03689 367928001915 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928001916 Walker A motif; other site 367928001917 ATP binding site [chemical binding]; other site 367928001918 Walker B motif; other site 367928001919 arginine finger; other site 367928001920 Pup-ligase protein; Region: Pup_ligase; pfam03136 367928001921 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 367928001922 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 367928001923 active site 367928001924 Pup-ligase protein; Region: Pup_ligase; cl15463 367928001925 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 367928001926 IHF dimer interface [polypeptide binding]; other site 367928001927 IHF - DNA interface [nucleotide binding]; other site 367928001928 Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219 367928001929 adenylosuccinate lyase; Provisional; Region: PRK09285 367928001930 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 367928001931 tetramer interface [polypeptide binding]; other site 367928001932 active site 367928001933 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 367928001934 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 367928001935 nucleophilic elbow; other site 367928001936 catalytic triad; other site 367928001937 von Willebrand factor type A domain; Region: VWA_2; pfam13519 367928001938 metal ion-dependent adhesion site (MIDAS); other site 367928001939 von Willebrand factor type A domain; Region: VWA_2; pfam13519 367928001940 Protein of unknown function DUF58; Region: DUF58; pfam01882 367928001941 MoxR-like ATPases [General function prediction only]; Region: COG0714 367928001942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 367928001943 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 367928001944 ligand binding site [chemical binding]; other site 367928001945 active site 367928001946 UGI interface [polypeptide binding]; other site 367928001947 catalytic site [active] 367928001948 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 367928001949 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 367928001950 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 367928001951 ring oligomerisation interface [polypeptide binding]; other site 367928001952 ATP/Mg binding site [chemical binding]; other site 367928001953 stacking interactions; other site 367928001954 hinge regions; other site 367928001955 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 367928001956 Repair protein; Region: Repair_PSII; cl01535 367928001957 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367928001958 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928001959 active site 367928001960 phosphorylation site [posttranslational modification] 367928001961 intermolecular recognition site; other site 367928001962 dimerization interface [polypeptide binding]; other site 367928001963 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367928001964 DNA binding site [nucleotide binding] 367928001965 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367928001966 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 367928001967 dimerization interface [polypeptide binding]; other site 367928001968 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367928001969 dimer interface [polypeptide binding]; other site 367928001970 phosphorylation site [posttranslational modification] 367928001971 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928001972 ATP binding site [chemical binding]; other site 367928001973 Mg2+ binding site [ion binding]; other site 367928001974 G-X-G motif; other site 367928001975 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 367928001976 DNA-binding site [nucleotide binding]; DNA binding site 367928001977 RNA-binding motif; other site 367928001978 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 367928001979 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 367928001980 Ligand Binding Site [chemical binding]; other site 367928001981 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 367928001982 Ligand Binding Site [chemical binding]; other site 367928001983 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 367928001984 Clp amino terminal domain; Region: Clp_N; pfam02861 367928001985 Clp amino terminal domain; Region: Clp_N; pfam02861 367928001986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928001987 Walker A motif; other site 367928001988 ATP binding site [chemical binding]; other site 367928001989 Walker B motif; other site 367928001990 arginine finger; other site 367928001991 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928001992 Walker A motif; other site 367928001993 ATP binding site [chemical binding]; other site 367928001994 Walker B motif; other site 367928001995 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 367928001996 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 367928001997 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 367928001998 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 367928001999 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 367928002000 dimer interface [polypeptide binding]; other site 367928002001 motif 1; other site 367928002002 active site 367928002003 motif 2; other site 367928002004 motif 3; other site 367928002005 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 367928002006 anticodon binding site; other site 367928002007 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 367928002008 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 367928002009 dimer interface [polypeptide binding]; other site 367928002010 anticodon binding site; other site 367928002011 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 367928002012 motif 1; other site 367928002013 dimer interface [polypeptide binding]; other site 367928002014 active site 367928002015 motif 2; other site 367928002016 GAD domain; Region: GAD; pfam02938 367928002017 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 367928002018 active site 367928002019 motif 3; other site 367928002020 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367928002021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367928002022 substrate binding pocket [chemical binding]; other site 367928002023 membrane-bound complex binding site; other site 367928002024 hinge residues; other site 367928002025 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 367928002026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928002027 dimer interface [polypeptide binding]; other site 367928002028 conserved gate region; other site 367928002029 putative PBP binding loops; other site 367928002030 ABC-ATPase subunit interface; other site 367928002031 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 367928002032 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 367928002033 Walker A/P-loop; other site 367928002034 ATP binding site [chemical binding]; other site 367928002035 Q-loop/lid; other site 367928002036 ABC transporter signature motif; other site 367928002037 Walker B; other site 367928002038 D-loop; other site 367928002039 H-loop/switch region; other site 367928002040 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 367928002041 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 367928002042 Walker A/P-loop; other site 367928002043 ATP binding site [chemical binding]; other site 367928002044 Q-loop/lid; other site 367928002045 ABC transporter signature motif; other site 367928002046 Walker B; other site 367928002047 D-loop; other site 367928002048 H-loop/switch region; other site 367928002049 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367928002050 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367928002051 substrate binding pocket [chemical binding]; other site 367928002052 membrane-bound complex binding site; other site 367928002053 hinge residues; other site 367928002054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928002055 dimer interface [polypeptide binding]; other site 367928002056 conserved gate region; other site 367928002057 ABC-ATPase subunit interface; other site 367928002058 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 367928002059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928002060 dimer interface [polypeptide binding]; other site 367928002061 conserved gate region; other site 367928002062 putative PBP binding loops; other site 367928002063 ABC-ATPase subunit interface; other site 367928002064 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 367928002065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928002066 ATP binding site [chemical binding]; other site 367928002067 putative Mg++ binding site [ion binding]; other site 367928002068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928002069 nucleotide binding region [chemical binding]; other site 367928002070 ATP-binding site [chemical binding]; other site 367928002071 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 367928002072 recombination factor protein RarA; Reviewed; Region: PRK13342 367928002073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928002074 Walker A motif; other site 367928002075 ATP binding site [chemical binding]; other site 367928002076 Walker B motif; other site 367928002077 arginine finger; other site 367928002078 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 367928002079 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928002080 putative substrate translocation pore; other site 367928002081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928002082 Clp protease; Region: CLP_protease; pfam00574 367928002083 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 367928002084 oligomer interface [polypeptide binding]; other site 367928002085 active site residues [active] 367928002086 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 367928002087 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 367928002088 oligomer interface [polypeptide binding]; other site 367928002089 active site residues [active] 367928002090 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 367928002091 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 367928002092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928002093 Walker A motif; other site 367928002094 ATP binding site [chemical binding]; other site 367928002095 Walker B motif; other site 367928002096 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 367928002097 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 367928002098 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 367928002099 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 367928002100 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 367928002101 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 367928002102 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 367928002103 L-aspartate oxidase; Provisional; Region: PRK06175 367928002104 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 367928002105 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 367928002106 DNA protecting protein DprA; Region: dprA; TIGR00732 367928002107 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 367928002108 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 367928002109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928002110 Walker A motif; other site 367928002111 ATP binding site [chemical binding]; other site 367928002112 Walker B motif; other site 367928002113 arginine finger; other site 367928002114 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 367928002115 hypothetical protein; Provisional; Region: PRK14681 367928002116 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 367928002117 dimer interface [polypeptide binding]; other site 367928002118 pyridoxal binding site [chemical binding]; other site 367928002119 ATP binding site [chemical binding]; other site 367928002120 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 367928002121 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 367928002122 homodimer interface [polypeptide binding]; other site 367928002123 substrate-cofactor binding pocket; other site 367928002124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928002125 catalytic residue [active] 367928002126 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 367928002127 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 367928002128 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 367928002129 Walker A/P-loop; other site 367928002130 ATP binding site [chemical binding]; other site 367928002131 Q-loop/lid; other site 367928002132 ABC transporter signature motif; other site 367928002133 Walker B; other site 367928002134 D-loop; other site 367928002135 H-loop/switch region; other site 367928002136 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 367928002137 Walker A/P-loop; other site 367928002138 ATP binding site [chemical binding]; other site 367928002139 Q-loop/lid; other site 367928002140 ABC transporter signature motif; other site 367928002141 Walker B; other site 367928002142 D-loop; other site 367928002143 H-loop/switch region; other site 367928002144 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 367928002145 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 367928002146 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 367928002147 AsnC family; Region: AsnC_trans_reg; pfam01037 367928002148 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 367928002149 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 367928002150 AsnC family; Region: AsnC_trans_reg; pfam01037 367928002151 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928002152 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367928002153 Walker A/P-loop; other site 367928002154 ATP binding site [chemical binding]; other site 367928002155 Q-loop/lid; other site 367928002156 ABC transporter signature motif; other site 367928002157 Walker B; other site 367928002158 D-loop; other site 367928002159 H-loop/switch region; other site 367928002160 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 367928002161 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928002162 FtsX-like permease family; Region: FtsX; pfam02687 367928002163 FtsX-like permease family; Region: FtsX; pfam02687 367928002164 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 367928002165 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928002166 active site 367928002167 phosphorylation site [posttranslational modification] 367928002168 intermolecular recognition site; other site 367928002169 dimerization interface [polypeptide binding]; other site 367928002170 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 367928002171 DNA binding residues [nucleotide binding] 367928002172 dimerization interface [polypeptide binding]; other site 367928002173 Histidine kinase; Region: HisKA_3; pfam07730 367928002174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928002175 ATP binding site [chemical binding]; other site 367928002176 Mg2+ binding site [ion binding]; other site 367928002177 G-X-G motif; other site 367928002178 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 367928002179 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 367928002180 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 367928002181 GTP-binding protein YchF; Reviewed; Region: PRK09601 367928002182 YchF GTPase; Region: YchF; cd01900 367928002183 G1 box; other site 367928002184 GTP/Mg2+ binding site [chemical binding]; other site 367928002185 Switch I region; other site 367928002186 G2 box; other site 367928002187 Switch II region; other site 367928002188 G3 box; other site 367928002189 G4 box; other site 367928002190 G5 box; other site 367928002191 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 367928002192 FeoA domain; Region: FeoA; pfam04023 367928002193 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 367928002194 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 367928002195 G1 box; other site 367928002196 GTP/Mg2+ binding site [chemical binding]; other site 367928002197 G2 box; other site 367928002198 Switch I region; other site 367928002199 G3 box; other site 367928002200 Switch II region; other site 367928002201 G4 box; other site 367928002202 G5 box; other site 367928002203 Nucleoside recognition; Region: Gate; pfam07670 367928002204 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 367928002205 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 367928002206 EamA-like transporter family; Region: EamA; pfam00892 367928002207 EamA-like transporter family; Region: EamA; pfam00892 367928002208 Predicted membrane protein [Function unknown]; Region: COG2855 367928002209 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 367928002210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367928002211 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 367928002212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367928002213 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928002214 catalytic core [active] 367928002215 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 367928002216 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 367928002217 classical (c) SDRs; Region: SDR_c; cd05233 367928002218 NAD(P) binding site [chemical binding]; other site 367928002219 active site 367928002220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 367928002221 DEAD-like helicases superfamily; Region: DEXDc; smart00487 367928002222 ATP binding site [chemical binding]; other site 367928002223 putative Mg++ binding site [ion binding]; other site 367928002224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928002225 nucleotide binding region [chemical binding]; other site 367928002226 ATP-binding site [chemical binding]; other site 367928002227 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 367928002228 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928002229 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928002230 Walker A/P-loop; other site 367928002231 ATP binding site [chemical binding]; other site 367928002232 Q-loop/lid; other site 367928002233 ABC transporter signature motif; other site 367928002234 Walker B; other site 367928002235 D-loop; other site 367928002236 H-loop/switch region; other site 367928002237 Putative esterase; Region: Esterase; pfam00756 367928002238 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 367928002239 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 367928002240 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 367928002241 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 367928002242 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 367928002243 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 367928002244 putative active site [active] 367928002245 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 367928002246 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 367928002247 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 367928002248 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 367928002249 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 367928002250 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 367928002251 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 367928002252 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 367928002253 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 367928002254 DNA binding site [nucleotide binding] 367928002255 active site 367928002256 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 367928002257 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928002258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928002259 homodimer interface [polypeptide binding]; other site 367928002260 catalytic residue [active] 367928002261 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 367928002262 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 367928002263 AzlC protein; Region: AzlC; cl00570 367928002264 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 367928002265 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 367928002266 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 367928002267 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 367928002268 Uncharacterized conserved protein [Function unknown]; Region: COG1615 367928002269 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 367928002270 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 367928002271 Coenzyme A binding pocket [chemical binding]; other site 367928002272 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 367928002273 putative active site [active] 367928002274 catalytic residue [active] 367928002275 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 367928002276 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 367928002277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928002278 ATP binding site [chemical binding]; other site 367928002279 putative Mg++ binding site [ion binding]; other site 367928002280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928002281 nucleotide binding region [chemical binding]; other site 367928002282 ATP-binding site [chemical binding]; other site 367928002283 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 367928002284 enolase; Provisional; Region: eno; PRK00077 367928002285 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 367928002286 dimer interface [polypeptide binding]; other site 367928002287 metal binding site [ion binding]; metal-binding site 367928002288 substrate binding pocket [chemical binding]; other site 367928002289 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 367928002290 Septum formation initiator; Region: DivIC; pfam04977 367928002291 Protein of unknown function (DUF501); Region: DUF501; pfam04417 367928002292 exopolyphosphatase; Region: exo_poly_only; TIGR03706 367928002293 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 367928002294 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 367928002295 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 367928002296 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 367928002297 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 367928002298 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 367928002299 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 367928002300 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 367928002301 Haemolysin-III related; Region: HlyIII; pfam03006 367928002302 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 367928002303 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 367928002304 PAS fold; Region: PAS_4; pfam08448 367928002305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 367928002306 Histidine kinase; Region: HisKA_2; pfam07568 367928002307 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928002308 ATP binding site [chemical binding]; other site 367928002309 Mg2+ binding site [ion binding]; other site 367928002310 G-X-G motif; other site 367928002311 Transcription factor WhiB; Region: Whib; pfam02467 367928002312 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 367928002313 Transcriptional regulator [Transcription]; Region: LytR; COG1316 367928002314 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 367928002315 Transcription factor WhiB; Region: Whib; pfam02467 367928002316 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 367928002317 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 367928002318 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 367928002319 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 367928002320 Eukaryotic phosphomannomutase; Region: PMM; cl17107 367928002321 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 367928002322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367928002323 active site 367928002324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 367928002325 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 367928002326 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 367928002327 dimerization interface [polypeptide binding]; other site 367928002328 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 367928002329 dimer interface [polypeptide binding]; other site 367928002330 phosphorylation site [posttranslational modification] 367928002331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928002332 ATP binding site [chemical binding]; other site 367928002333 Mg2+ binding site [ion binding]; other site 367928002334 G-X-G motif; other site 367928002335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367928002336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928002337 active site 367928002338 phosphorylation site [posttranslational modification] 367928002339 intermolecular recognition site; other site 367928002340 dimerization interface [polypeptide binding]; other site 367928002341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367928002342 DNA binding site [nucleotide binding] 367928002343 glycogen branching enzyme; Provisional; Region: PRK05402 367928002344 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 367928002345 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 367928002346 active site 367928002347 catalytic site [active] 367928002348 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 367928002349 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 367928002350 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 367928002351 homotrimer interaction site [polypeptide binding]; other site 367928002352 zinc binding site [ion binding]; other site 367928002353 CDP-binding sites; other site 367928002354 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 367928002355 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 367928002356 ABC-ATPase subunit interface; other site 367928002357 dimer interface [polypeptide binding]; other site 367928002358 putative PBP binding regions; other site 367928002359 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 367928002360 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 367928002361 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 367928002362 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 367928002363 intersubunit interface [polypeptide binding]; other site 367928002364 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 367928002365 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 367928002366 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 367928002367 homodimer interface [polypeptide binding]; other site 367928002368 NADP binding site [chemical binding]; other site 367928002369 substrate binding site [chemical binding]; other site 367928002370 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 367928002371 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 367928002372 RNA binding site [nucleotide binding]; other site 367928002373 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 367928002374 RNA binding site [nucleotide binding]; other site 367928002375 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 367928002376 RNA binding site [nucleotide binding]; other site 367928002377 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 367928002378 RNA binding site [nucleotide binding]; other site 367928002379 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 367928002380 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 367928002381 CoA-binding site [chemical binding]; other site 367928002382 ATP-binding [chemical binding]; other site 367928002383 excinuclease ABC subunit B; Provisional; Region: PRK05298 367928002384 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928002385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928002386 nucleotide binding region [chemical binding]; other site 367928002387 ATP-binding site [chemical binding]; other site 367928002388 Ultra-violet resistance protein B; Region: UvrB; pfam12344 367928002389 UvrB/uvrC motif; Region: UVR; pfam02151 367928002390 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 367928002391 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 367928002392 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 367928002393 domain interfaces; other site 367928002394 active site 367928002395 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 367928002396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928002397 active site 367928002398 phosphorylation site [posttranslational modification] 367928002399 intermolecular recognition site; other site 367928002400 dimerization interface [polypeptide binding]; other site 367928002401 ANTAR domain; Region: ANTAR; pfam03861 367928002402 DNA polymerase I; Provisional; Region: PRK05755 367928002403 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 367928002404 active site 367928002405 metal binding site 1 [ion binding]; metal-binding site 367928002406 putative 5' ssDNA interaction site; other site 367928002407 metal binding site 3; metal-binding site 367928002408 metal binding site 2 [ion binding]; metal-binding site 367928002409 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 367928002410 putative DNA binding site [nucleotide binding]; other site 367928002411 putative metal binding site [ion binding]; other site 367928002412 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 367928002413 active site 367928002414 substrate binding site [chemical binding]; other site 367928002415 catalytic site [active] 367928002416 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 367928002417 active site 367928002418 DNA binding site [nucleotide binding] 367928002419 catalytic site [active] 367928002420 Uncharacterized conserved protein [Function unknown]; Region: COG0327 367928002421 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 367928002422 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 367928002423 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 367928002424 dimer interface [polypeptide binding]; other site 367928002425 ADP-ribose binding site [chemical binding]; other site 367928002426 active site 367928002427 nudix motif; other site 367928002428 metal binding site [ion binding]; metal-binding site 367928002429 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 367928002430 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 367928002431 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 367928002432 active site 367928002433 catalytic site [active] 367928002434 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 367928002435 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 367928002436 hinge; other site 367928002437 active site 367928002438 GMP synthase; Reviewed; Region: guaA; PRK00074 367928002439 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 367928002440 AMP/PPi binding site [chemical binding]; other site 367928002441 candidate oxyanion hole; other site 367928002442 catalytic triad [active] 367928002443 potential glutamine specificity residues [chemical binding]; other site 367928002444 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 367928002445 ATP Binding subdomain [chemical binding]; other site 367928002446 Ligand Binding sites [chemical binding]; other site 367928002447 Dimerization subdomain; other site 367928002448 putative phosphoketolase; Provisional; Region: PRK05261 367928002449 XFP N-terminal domain; Region: XFP_N; pfam09364 367928002450 XFP C-terminal domain; Region: XFP_C; pfam09363 367928002451 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 367928002452 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 367928002453 propionate/acetate kinase; Provisional; Region: PRK12379 367928002454 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 367928002455 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 367928002456 catalytic triad [active] 367928002457 catalytic triad [active] 367928002458 oxyanion hole [active] 367928002459 xanthine permease; Region: pbuX; TIGR03173 367928002460 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367928002461 active site 367928002462 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 367928002463 Part of AAA domain; Region: AAA_19; pfam13245 367928002464 Family description; Region: UvrD_C_2; pfam13538 367928002465 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 367928002466 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928002467 FtsX-like permease family; Region: FtsX; pfam02687 367928002468 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928002469 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367928002470 Walker A/P-loop; other site 367928002471 ATP binding site [chemical binding]; other site 367928002472 Q-loop/lid; other site 367928002473 ABC transporter signature motif; other site 367928002474 Walker B; other site 367928002475 D-loop; other site 367928002476 H-loop/switch region; other site 367928002477 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 367928002478 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 367928002479 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 367928002480 RNA binding surface [nucleotide binding]; other site 367928002481 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928002482 catalytic core [active] 367928002483 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 367928002484 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 367928002485 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 367928002486 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 367928002487 motif 1; other site 367928002488 active site 367928002489 motif 2; other site 367928002490 motif 3; other site 367928002491 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 367928002492 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 367928002493 YceG-like family; Region: YceG; pfam02618 367928002494 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 367928002495 dimerization interface [polypeptide binding]; other site 367928002496 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 367928002497 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 367928002498 Tetramer interface [polypeptide binding]; other site 367928002499 active site 367928002500 FMN-binding site [chemical binding]; other site 367928002501 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 367928002502 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 367928002503 ADP binding site [chemical binding]; other site 367928002504 magnesium binding site [ion binding]; other site 367928002505 putative shikimate binding site; other site 367928002506 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 367928002507 active site 367928002508 dimer interface [polypeptide binding]; other site 367928002509 metal binding site [ion binding]; metal-binding site 367928002510 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 367928002511 Dehydroquinase class II; Region: DHquinase_II; pfam01220 367928002512 trimer interface [polypeptide binding]; other site 367928002513 active site 367928002514 dimer interface [polypeptide binding]; other site 367928002515 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 367928002516 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 367928002517 active site 367928002518 Ca binding site [ion binding]; other site 367928002519 catalytic site [active] 367928002520 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 367928002521 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 367928002522 active site 367928002523 Ca binding site [ion binding]; other site 367928002524 catalytic site [active] 367928002525 Aamy_C domain; Region: Aamy_C; smart00632 367928002526 Carbohydrate binding domain; Region: CBM_25; smart01066 367928002527 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 367928002528 carbohydrate binding site [chemical binding]; other site 367928002529 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 367928002530 carbohydrate binding site [chemical binding]; other site 367928002531 pullulanase, type I; Region: pulA_typeI; TIGR02104 367928002532 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 367928002533 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 367928002534 Ca binding site [ion binding]; other site 367928002535 active site 367928002536 catalytic site [active] 367928002537 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 367928002538 CTP synthetase; Validated; Region: pyrG; PRK05380 367928002539 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 367928002540 Catalytic site [active] 367928002541 active site 367928002542 UTP binding site [chemical binding]; other site 367928002543 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 367928002544 active site 367928002545 putative oxyanion hole; other site 367928002546 catalytic triad [active] 367928002547 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 367928002548 FeS assembly protein SufB; Region: sufB; TIGR01980 367928002549 FeS assembly protein SufD; Region: sufD; TIGR01981 367928002550 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 367928002551 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 367928002552 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 367928002553 Walker A/P-loop; other site 367928002554 ATP binding site [chemical binding]; other site 367928002555 Q-loop/lid; other site 367928002556 ABC transporter signature motif; other site 367928002557 Walker B; other site 367928002558 D-loop; other site 367928002559 H-loop/switch region; other site 367928002560 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 367928002561 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 367928002562 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 367928002563 catalytic residue [active] 367928002564 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 367928002565 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 367928002566 trimerization site [polypeptide binding]; other site 367928002567 active site 367928002568 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 367928002569 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 367928002570 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 367928002571 ligand binding site; other site 367928002572 oligomer interface; other site 367928002573 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 367928002574 dimer interface [polypeptide binding]; other site 367928002575 N-terminal domain interface [polypeptide binding]; other site 367928002576 sulfate 1 binding site; other site 367928002577 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 367928002578 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 367928002579 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 367928002580 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 367928002581 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 367928002582 nucleotide binding site/active site [active] 367928002583 HIT family signature motif; other site 367928002584 catalytic residue [active] 367928002585 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 367928002586 PhoH-like protein; Region: PhoH; pfam02562 367928002587 metal-binding heat shock protein; Provisional; Region: PRK00016 367928002588 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 367928002589 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 367928002590 Transporter associated domain; Region: CorC_HlyC; smart01091 367928002591 GTPase Era; Reviewed; Region: era; PRK00089 367928002592 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 367928002593 G1 box; other site 367928002594 GTP/Mg2+ binding site [chemical binding]; other site 367928002595 Switch I region; other site 367928002596 G2 box; other site 367928002597 Switch II region; other site 367928002598 G3 box; other site 367928002599 G4 box; other site 367928002600 G5 box; other site 367928002601 KH domain; Region: KH_2; pfam07650 367928002602 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 367928002603 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 367928002604 acyl-activating enzyme (AAE) consensus motif; other site 367928002605 putative AMP binding site [chemical binding]; other site 367928002606 putative active site [active] 367928002607 putative CoA binding site [chemical binding]; other site 367928002608 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 367928002609 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 367928002610 ligand binding site [chemical binding]; other site 367928002611 homodimer interface [polypeptide binding]; other site 367928002612 NAD(P) binding site [chemical binding]; other site 367928002613 trimer interface B [polypeptide binding]; other site 367928002614 trimer interface A [polypeptide binding]; other site 367928002615 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 367928002616 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 367928002617 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 367928002618 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 367928002619 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 367928002620 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 367928002621 DNA binding residues [nucleotide binding] 367928002622 drug binding residues [chemical binding]; other site 367928002623 dimer interface [polypeptide binding]; other site 367928002624 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 367928002625 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 367928002626 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 367928002627 Transcriptional regulators [Transcription]; Region: MarR; COG1846 367928002628 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367928002629 putative Zn2+ binding site [ion binding]; other site 367928002630 putative DNA binding site [nucleotide binding]; other site 367928002631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928002632 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928002633 putative substrate translocation pore; other site 367928002634 CrcB-like protein; Region: CRCB; pfam02537 367928002635 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 367928002636 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 367928002637 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 367928002638 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 367928002639 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 367928002640 Walker A/P-loop; other site 367928002641 ATP binding site [chemical binding]; other site 367928002642 Q-loop/lid; other site 367928002643 ABC transporter signature motif; other site 367928002644 Walker B; other site 367928002645 D-loop; other site 367928002646 H-loop/switch region; other site 367928002647 Second domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain2; cd03226 367928002648 Walker A/P-loop; other site 367928002649 ATP binding site [chemical binding]; other site 367928002650 Q-loop/lid; other site 367928002651 ABC transporter signature motif; other site 367928002652 Walker B; other site 367928002653 D-loop; other site 367928002654 H-loop/switch region; other site 367928002655 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928002656 Walker A/P-loop; other site 367928002657 ATP binding site [chemical binding]; other site 367928002658 Q-loop/lid; other site 367928002659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928002660 ABC transporter signature motif; other site 367928002661 Walker B; other site 367928002662 D-loop; other site 367928002663 H-loop/switch region; other site 367928002664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928002665 AAA domain; Region: AAA_21; pfam13304 367928002666 Walker A/P-loop; other site 367928002667 ATP binding site [chemical binding]; other site 367928002668 Q-loop/lid; other site 367928002669 ABC transporter signature motif; other site 367928002670 Walker B; other site 367928002671 D-loop; other site 367928002672 H-loop/switch region; other site 367928002673 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 367928002674 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 367928002675 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 367928002676 5S rRNA interface [nucleotide binding]; other site 367928002677 CTC domain interface [polypeptide binding]; other site 367928002678 L16 interface [polypeptide binding]; other site 367928002679 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 367928002680 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 367928002681 homodimer interface [polypeptide binding]; other site 367928002682 substrate-cofactor binding pocket; other site 367928002683 catalytic residue [active] 367928002684 UPF0126 domain; Region: UPF0126; pfam03458 367928002685 Predicted membrane protein [Function unknown]; Region: COG2860 367928002686 UPF0126 domain; Region: UPF0126; pfam03458 367928002687 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 367928002688 GTP-binding protein LepA; Provisional; Region: PRK05433 367928002689 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 367928002690 Switch I region; other site 367928002691 G2 box; other site 367928002692 putative GEF interaction site [polypeptide binding]; other site 367928002693 G3 box; other site 367928002694 Switch II region; other site 367928002695 GTP/Mg2+ binding site [chemical binding]; other site 367928002696 G4 box; other site 367928002697 G5 box; other site 367928002698 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 367928002699 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 367928002700 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 367928002701 coproporphyrinogen III oxidase; Validated; Region: PRK05628 367928002702 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367928002703 FeS/SAM binding site; other site 367928002704 HemN C-terminal domain; Region: HemN_C; pfam06969 367928002705 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 367928002706 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 367928002707 active site 367928002708 dimer interface [polypeptide binding]; other site 367928002709 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 367928002710 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 367928002711 active site 367928002712 FMN binding site [chemical binding]; other site 367928002713 substrate binding site [chemical binding]; other site 367928002714 3Fe-4S cluster binding site [ion binding]; other site 367928002715 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 367928002716 domain interface; other site 367928002717 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 367928002718 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 367928002719 photosystem II protein J; Region: psbJ; CHL00108 367928002720 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 367928002721 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 367928002722 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 367928002723 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 367928002724 Walker A/P-loop; other site 367928002725 ATP binding site [chemical binding]; other site 367928002726 Q-loop/lid; other site 367928002727 ABC transporter signature motif; other site 367928002728 Walker B; other site 367928002729 D-loop; other site 367928002730 H-loop/switch region; other site 367928002731 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 367928002732 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367928002733 S-adenosylmethionine binding site [chemical binding]; other site 367928002734 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928002735 catalytic core [active] 367928002736 Cupin domain; Region: Cupin_2; cl17218 367928002737 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 367928002738 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 367928002739 THF binding site; other site 367928002740 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 367928002741 substrate binding site [chemical binding]; other site 367928002742 THF binding site; other site 367928002743 zinc-binding site [ion binding]; other site 367928002744 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 367928002745 FAD binding site [chemical binding]; other site 367928002746 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 367928002747 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 367928002748 metal binding triad; other site 367928002749 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 367928002750 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 367928002751 metal binding triad; other site 367928002752 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 367928002753 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 367928002754 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 367928002755 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 367928002756 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 367928002757 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 367928002758 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 367928002759 dihydroorotase; Validated; Region: pyrC; PRK09357 367928002760 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 367928002761 active site 367928002762 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 367928002763 active site 367928002764 dimer interface [polypeptide binding]; other site 367928002765 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 367928002766 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 367928002767 FAD binding pocket [chemical binding]; other site 367928002768 FAD binding motif [chemical binding]; other site 367928002769 phosphate binding motif [ion binding]; other site 367928002770 beta-alpha-beta structure motif; other site 367928002771 NAD binding pocket [chemical binding]; other site 367928002772 Iron coordination center [ion binding]; other site 367928002773 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 367928002774 heterodimer interface [polypeptide binding]; other site 367928002775 active site 367928002776 FMN binding site [chemical binding]; other site 367928002777 homodimer interface [polypeptide binding]; other site 367928002778 substrate binding site [chemical binding]; other site 367928002779 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367928002780 active site 367928002781 Transcriptional regulator [Transcription]; Region: LysR; COG0583 367928002782 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 367928002783 Transcriptional regulator [Transcription]; Region: LysR; COG0583 367928002784 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 367928002785 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 367928002786 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928002787 motif II; other site 367928002788 FtsX-like permease family; Region: FtsX; pfam02687 367928002789 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928002790 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 367928002791 FtsX-like permease family; Region: FtsX; pfam02687 367928002792 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 367928002793 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 367928002794 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928002795 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367928002796 Walker A/P-loop; other site 367928002797 ATP binding site [chemical binding]; other site 367928002798 Q-loop/lid; other site 367928002799 ABC transporter signature motif; other site 367928002800 Walker B; other site 367928002801 D-loop; other site 367928002802 H-loop/switch region; other site 367928002803 Peptidase family M23; Region: Peptidase_M23; pfam01551 367928002804 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 367928002805 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 367928002806 acyl-activating enzyme (AAE) consensus motif; other site 367928002807 putative AMP binding site [chemical binding]; other site 367928002808 putative active site [active] 367928002809 putative CoA binding site [chemical binding]; other site 367928002810 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 367928002811 isocitrate dehydrogenase; Validated; Region: PRK08299 367928002812 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 367928002813 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 367928002814 active site 367928002815 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 367928002816 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 367928002817 acyl-activating enzyme (AAE) consensus motif; other site 367928002818 putative AMP binding site [chemical binding]; other site 367928002819 putative active site [active] 367928002820 putative CoA binding site [chemical binding]; other site 367928002821 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cl00234 367928002822 active site 367928002823 metal binding site [ion binding]; metal-binding site 367928002824 catalytic residues [active] 367928002825 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 367928002826 rRNA interaction site [nucleotide binding]; other site 367928002827 S8 interaction site; other site 367928002828 putative laminin-1 binding site; other site 367928002829 elongation factor Ts; Provisional; Region: tsf; PRK09377 367928002830 UBA/TS-N domain; Region: UBA; pfam00627 367928002831 Elongation factor TS; Region: EF_TS; pfam00889 367928002832 Elongation factor TS; Region: EF_TS; pfam00889 367928002833 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 367928002834 putative nucleotide binding site [chemical binding]; other site 367928002835 uridine monophosphate binding site [chemical binding]; other site 367928002836 homohexameric interface [polypeptide binding]; other site 367928002837 ribosome recycling factor; Reviewed; Region: frr; PRK00083 367928002838 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 367928002839 hinge region; other site 367928002840 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 367928002841 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 367928002842 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 367928002843 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367928002844 FeS/SAM binding site; other site 367928002845 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 367928002846 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 367928002847 substrate binding site [chemical binding]; other site 367928002848 glutamase interaction surface [polypeptide binding]; other site 367928002849 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 367928002850 anthranilate synthase component I; Provisional; Region: PRK13571 367928002851 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 367928002852 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 367928002853 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 367928002854 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 367928002855 active site 367928002856 ribulose/triose binding site [chemical binding]; other site 367928002857 phosphate binding site [ion binding]; other site 367928002858 substrate (anthranilate) binding pocket [chemical binding]; other site 367928002859 product (indole) binding pocket [chemical binding]; other site 367928002860 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 367928002861 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928002862 catalytic residue [active] 367928002863 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 367928002864 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 367928002865 substrate binding site [chemical binding]; other site 367928002866 active site 367928002867 catalytic residues [active] 367928002868 heterodimer interface [polypeptide binding]; other site 367928002869 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 367928002870 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 367928002871 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 367928002872 substrate binding site [chemical binding]; other site 367928002873 hexamer interface [polypeptide binding]; other site 367928002874 metal binding site [ion binding]; metal-binding site 367928002875 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 367928002876 homodimer interface [polypeptide binding]; other site 367928002877 putative metal binding site [ion binding]; other site 367928002878 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 367928002879 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 367928002880 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 367928002881 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 367928002882 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 367928002883 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 367928002884 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 367928002885 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 367928002886 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 367928002887 thiS-thiF/thiG interaction site; other site 367928002888 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 367928002889 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 367928002890 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 367928002891 active site 367928002892 dimer interface [polypeptide binding]; other site 367928002893 motif 1; other site 367928002894 motif 2; other site 367928002895 motif 3; other site 367928002896 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 367928002897 anticodon binding site; other site 367928002898 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 367928002899 hypothetical protein; Validated; Region: PRK00110 367928002900 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 367928002901 active site 367928002902 putative DNA-binding cleft [nucleotide binding]; other site 367928002903 dimer interface [polypeptide binding]; other site 367928002904 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 367928002905 RuvA N terminal domain; Region: RuvA_N; pfam01330 367928002906 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 367928002907 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 367928002908 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 367928002909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928002910 Walker A motif; other site 367928002911 ATP binding site [chemical binding]; other site 367928002912 Walker B motif; other site 367928002913 arginine finger; other site 367928002914 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 367928002915 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367928002916 active site 367928002917 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 367928002918 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 367928002919 CoA-ligase; Region: Ligase_CoA; pfam00549 367928002920 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 367928002921 CoA binding domain; Region: CoA_binding; smart00881 367928002922 CoA-ligase; Region: Ligase_CoA; pfam00549 367928002923 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 367928002924 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 367928002925 purine monophosphate binding site [chemical binding]; other site 367928002926 dimer interface [polypeptide binding]; other site 367928002927 putative catalytic residues [active] 367928002928 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 367928002929 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 367928002930 amphipathic channel; other site 367928002931 Asn-Pro-Ala signature motifs; other site 367928002932 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 367928002933 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 367928002934 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 367928002935 G1 box; other site 367928002936 GTP/Mg2+ binding site [chemical binding]; other site 367928002937 Switch I region; other site 367928002938 G2 box; other site 367928002939 Switch II region; other site 367928002940 G3 box; other site 367928002941 G4 box; other site 367928002942 G5 box; other site 367928002943 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 367928002944 G1 box; other site 367928002945 GTP/Mg2+ binding site [chemical binding]; other site 367928002946 Switch I region; other site 367928002947 G2 box; other site 367928002948 G3 box; other site 367928002949 Switch II region; other site 367928002950 G4 box; other site 367928002951 G5 box; other site 367928002952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 367928002953 active site 367928002954 Predicted transcriptional regulator [Transcription]; Region: COG2378 367928002955 WYL domain; Region: WYL; pfam13280 367928002956 DEAD-like helicases superfamily; Region: DEXDc; smart00487 367928002957 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928002958 ATP binding site [chemical binding]; other site 367928002959 putative Mg++ binding site [ion binding]; other site 367928002960 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928002961 nucleotide binding region [chemical binding]; other site 367928002962 ATP-binding site [chemical binding]; other site 367928002963 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 367928002964 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 367928002965 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 367928002966 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928002967 motif II; other site 367928002968 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 367928002969 DNA binding residues [nucleotide binding] 367928002970 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 367928002971 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 367928002972 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 367928002973 phosphopeptide binding site; other site 367928002974 PAC2 family; Region: PAC2; pfam09754 367928002975 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 367928002976 Fructosamine kinase; Region: Fructosamin_kin; cl17579 367928002977 Phosphotransferase enzyme family; Region: APH; pfam01636 367928002978 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 367928002979 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 367928002980 HSP70 interaction site [polypeptide binding]; other site 367928002981 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 367928002982 Zn binding sites [ion binding]; other site 367928002983 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 367928002984 dimer interface [polypeptide binding]; other site 367928002985 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 367928002986 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 367928002987 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 367928002988 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 367928002989 TPP-binding site [chemical binding]; other site 367928002990 dimer interface [polypeptide binding]; other site 367928002991 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 367928002992 PYR/PP interface [polypeptide binding]; other site 367928002993 dimer interface [polypeptide binding]; other site 367928002994 TPP binding site [chemical binding]; other site 367928002995 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 367928002996 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 367928002997 putative active site [active] 367928002998 transaldolase; Provisional; Region: PRK03903 367928002999 catalytic residue [active] 367928003000 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 367928003001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367928003002 non-specific DNA binding site [nucleotide binding]; other site 367928003003 salt bridge; other site 367928003004 sequence-specific DNA binding site [nucleotide binding]; other site 367928003005 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928003006 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928003007 homodimer interface [polypeptide binding]; other site 367928003008 catalytic residue [active] 367928003009 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 367928003010 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 367928003011 active site 367928003012 motif I; other site 367928003013 motif II; other site 367928003014 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 367928003015 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 367928003016 triosephosphate isomerase; Provisional; Region: PRK14567 367928003017 substrate binding site [chemical binding]; other site 367928003018 dimer interface [polypeptide binding]; other site 367928003019 catalytic triad [active] 367928003020 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 367928003021 Phosphoglycerate kinase; Region: PGK; pfam00162 367928003022 substrate binding site [chemical binding]; other site 367928003023 hinge regions; other site 367928003024 ADP binding site [chemical binding]; other site 367928003025 catalytic site [active] 367928003026 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 367928003027 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 367928003028 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 367928003029 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 367928003030 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 367928003031 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 367928003032 shikimate binding site; other site 367928003033 NAD(P) binding site [chemical binding]; other site 367928003034 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 367928003035 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 367928003036 GIY-YIG motif/motif A; other site 367928003037 active site 367928003038 catalytic site [active] 367928003039 putative DNA binding site [nucleotide binding]; other site 367928003040 metal binding site [ion binding]; metal-binding site 367928003041 UvrB/uvrC motif; Region: UVR; pfam02151 367928003042 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 367928003043 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 367928003044 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 367928003045 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 367928003046 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 367928003047 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 367928003048 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 367928003049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 367928003050 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 367928003051 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 367928003052 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 367928003053 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 367928003054 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 367928003055 VanZ like family; Region: VanZ; cl01971 367928003056 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367928003057 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 367928003058 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 367928003059 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928003060 Walker A/P-loop; other site 367928003061 ATP binding site [chemical binding]; other site 367928003062 Q-loop/lid; other site 367928003063 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367928003064 ABC transporter signature motif; other site 367928003065 Walker B; other site 367928003066 D-loop; other site 367928003067 Agouti protein; Region: Agouti; cl04902 367928003068 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 367928003069 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 367928003070 Cation efflux family; Region: Cation_efflux; pfam01545 367928003071 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 367928003072 substrate binding site [chemical binding]; other site 367928003073 THF binding site; other site 367928003074 zinc-binding site [ion binding]; other site 367928003075 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 367928003076 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 367928003077 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 367928003078 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 367928003079 DNA binding residues [nucleotide binding] 367928003080 putative dimer interface [polypeptide binding]; other site 367928003081 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 367928003082 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 367928003083 active site 367928003084 UGMP family protein; Validated; Region: PRK09604 367928003085 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 367928003086 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 367928003087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 367928003088 Coenzyme A binding pocket [chemical binding]; other site 367928003089 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 367928003090 Glycoprotease family; Region: Peptidase_M22; pfam00814 367928003091 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 367928003092 hypothetical protein; Validated; Region: PRK05629 367928003093 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 367928003094 Competence protein; Region: Competence; pfam03772 367928003095 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 367928003096 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 367928003097 Helix-hairpin-helix motif; Region: HHH; pfam00633 367928003098 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 367928003099 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367928003100 active site 367928003101 HIGH motif; other site 367928003102 nucleotide binding site [chemical binding]; other site 367928003103 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367928003104 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 367928003105 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367928003106 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367928003107 active site 367928003108 KMSKS motif; other site 367928003109 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 367928003110 tRNA binding surface [nucleotide binding]; other site 367928003111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367928003112 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367928003113 substrate binding pocket [chemical binding]; other site 367928003114 membrane-bound complex binding site; other site 367928003115 hinge residues; other site 367928003116 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 367928003117 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 367928003118 Cl binding site [ion binding]; other site 367928003119 oligomer interface [polypeptide binding]; other site 367928003120 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928003121 catalytic core [active] 367928003122 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928003123 catalytic core [active] 367928003124 Oligomerisation domain; Region: Oligomerisation; pfam02410 367928003125 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 367928003126 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 367928003127 Substrate binding site; other site 367928003128 Mg++ binding site; other site 367928003129 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 367928003130 active site 367928003131 substrate binding site [chemical binding]; other site 367928003132 CoA binding site [chemical binding]; other site 367928003133 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 367928003134 putative active site [active] 367928003135 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 367928003136 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 367928003137 active site 367928003138 catalytic tetrad [active] 367928003139 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 367928003140 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 367928003141 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 367928003142 DNA-binding interface [nucleotide binding]; DNA binding site 367928003143 Integrase core domain; Region: rve; pfam00665 367928003144 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 367928003145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928003146 Walker A motif; other site 367928003147 ATP binding site [chemical binding]; other site 367928003148 Walker B motif; other site 367928003149 arginine finger; other site 367928003150 Restriction endonuclease [Defense mechanisms]; Region: COG3587 367928003151 DivIVA domain; Region: DivI1A_domain; TIGR03544 367928003152 DivIVA domain; Region: DivI1A_domain; TIGR03544 367928003153 Protein of unknown function DUF262; Region: DUF262; pfam03235 367928003154 Uncharacterized conserved protein [Function unknown]; Region: COG1479 367928003155 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 367928003156 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 367928003157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 367928003158 Coenzyme A binding pocket [chemical binding]; other site 367928003159 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928003160 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 367928003161 FtsX-like permease family; Region: FtsX; pfam02687 367928003162 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928003163 FtsX-like permease family; Region: FtsX; pfam02687 367928003164 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928003165 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367928003166 Walker A/P-loop; other site 367928003167 ATP binding site [chemical binding]; other site 367928003168 Q-loop/lid; other site 367928003169 ABC transporter signature motif; other site 367928003170 Walker B; other site 367928003171 D-loop; other site 367928003172 H-loop/switch region; other site 367928003173 Predicted integral membrane protein [Function unknown]; Region: COG5658 367928003174 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 367928003175 SdpI/YhfL protein family; Region: SdpI; pfam13630 367928003176 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367928003177 dimerization interface [polypeptide binding]; other site 367928003178 putative DNA binding site [nucleotide binding]; other site 367928003179 putative Zn2+ binding site [ion binding]; other site 367928003180 YoaP-like; Region: YoaP; pfam14268 367928003181 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 367928003182 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 367928003183 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367928003184 active site 367928003185 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 367928003186 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 367928003187 active site 367928003188 (T/H)XGH motif; other site 367928003189 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 367928003190 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 367928003191 putative catalytic cysteine [active] 367928003192 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 367928003193 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 367928003194 dimer interface [polypeptide binding]; other site 367928003195 active site 367928003196 glycine-pyridoxal phosphate binding site [chemical binding]; other site 367928003197 folate binding site [chemical binding]; other site 367928003198 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 367928003199 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 367928003200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928003201 catalytic residue [active] 367928003202 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928003203 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928003204 putative substrate translocation pore; other site 367928003205 Predicted transcriptional regulators [Transcription]; Region: COG1725 367928003206 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 367928003207 DNA-binding site [nucleotide binding]; DNA binding site 367928003208 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 367928003209 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 367928003210 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928003211 motif II; other site 367928003212 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 367928003213 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928003214 Walker A/P-loop; other site 367928003215 ATP binding site [chemical binding]; other site 367928003216 Q-loop/lid; other site 367928003217 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 367928003218 ABC transporter signature motif; other site 367928003219 Walker B; other site 367928003220 D-loop; other site 367928003221 H-loop/switch region; other site 367928003222 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 367928003223 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 367928003224 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 367928003225 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 367928003226 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 367928003227 TrkA-N domain; Region: TrkA_N; pfam02254 367928003228 TrkA-C domain; Region: TrkA_C; pfam02080 367928003229 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 367928003230 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 367928003231 RNA binding surface [nucleotide binding]; other site 367928003232 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367928003233 S-adenosylmethionine binding site [chemical binding]; other site 367928003234 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 367928003235 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 367928003236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928003237 motif II; other site 367928003238 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 367928003239 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 367928003240 active site 367928003241 HIGH motif; other site 367928003242 dimer interface [polypeptide binding]; other site 367928003243 KMSKS motif; other site 367928003244 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 367928003245 RNA binding surface [nucleotide binding]; other site 367928003246 Predicted membrane protein [Function unknown]; Region: COG4905 367928003247 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 367928003248 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367928003249 Zn2+ binding site [ion binding]; other site 367928003250 Mg2+ binding site [ion binding]; other site 367928003251 argininosuccinate lyase; Provisional; Region: PRK00855 367928003252 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 367928003253 active sites [active] 367928003254 tetramer interface [polypeptide binding]; other site 367928003255 argininosuccinate synthase; Provisional; Region: PRK13820 367928003256 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 367928003257 ANP binding site [chemical binding]; other site 367928003258 Substrate Binding Site II [chemical binding]; other site 367928003259 Substrate Binding Site I [chemical binding]; other site 367928003260 arginine repressor; Provisional; Region: PRK03341 367928003261 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 367928003262 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 367928003263 ornithine carbamoyltransferase; Provisional; Region: PRK00779 367928003264 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 367928003265 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 367928003266 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 367928003267 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 367928003268 inhibitor-cofactor binding pocket; inhibition site 367928003269 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928003270 catalytic residue [active] 367928003271 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 367928003272 feedback inhibition sensing region; other site 367928003273 homohexameric interface [polypeptide binding]; other site 367928003274 nucleotide binding site [chemical binding]; other site 367928003275 N-acetyl-L-glutamate binding site [chemical binding]; other site 367928003276 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 367928003277 heterotetramer interface [polypeptide binding]; other site 367928003278 active site pocket [active] 367928003279 cleavage site 367928003280 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 367928003281 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 367928003282 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 367928003283 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 367928003284 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 367928003285 putative tRNA-binding site [nucleotide binding]; other site 367928003286 B3/4 domain; Region: B3_4; pfam03483 367928003287 tRNA synthetase B5 domain; Region: B5; pfam03484 367928003288 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 367928003289 dimer interface [polypeptide binding]; other site 367928003290 motif 1; other site 367928003291 motif 3; other site 367928003292 motif 2; other site 367928003293 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 367928003294 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 367928003295 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 367928003296 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 367928003297 dimer interface [polypeptide binding]; other site 367928003298 motif 1; other site 367928003299 active site 367928003300 motif 2; other site 367928003301 motif 3; other site 367928003302 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 367928003303 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 367928003304 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367928003305 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928003306 Walker A/P-loop; other site 367928003307 ATP binding site [chemical binding]; other site 367928003308 Q-loop/lid; other site 367928003309 ABC transporter signature motif; other site 367928003310 Walker B; other site 367928003311 D-loop; other site 367928003312 H-loop/switch region; other site 367928003313 xanthine permease; Region: pbuX; TIGR03173 367928003314 Acyl-protein synthetase, LuxE; Region: LuxE; pfam04443 367928003315 Acyl-CoA reductase LuxC; Region: ALDH_Acyl-CoA-Red_LuxC; cd07080 367928003316 Acyl-CoA reductase (LuxC); Region: LuxC; pfam05893 367928003317 putative catalytic cysteine [active] 367928003318 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 367928003319 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 367928003320 NAD(P) binding site [chemical binding]; other site 367928003321 active site 367928003322 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 367928003323 Membrane transport protein; Region: Mem_trans; cl09117 367928003324 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 367928003325 active site 367928003326 DNA binding site [nucleotide binding] 367928003327 Int/Topo IB signature motif; other site 367928003328 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 367928003329 Zeta toxin; Region: Zeta_toxin; pfam06414 367928003330 glutamine synthetase, type I; Region: GlnA; TIGR00653 367928003331 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 367928003332 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 367928003333 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 367928003334 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 367928003335 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 367928003336 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 367928003337 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 367928003338 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 367928003339 hypothetical protein; Provisional; Region: PRK07907 367928003340 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 367928003341 active site 367928003342 metal binding site [ion binding]; metal-binding site 367928003343 dimer interface [polypeptide binding]; other site 367928003344 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 367928003345 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 367928003346 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 367928003347 Walker A/P-loop; other site 367928003348 ATP binding site [chemical binding]; other site 367928003349 Q-loop/lid; other site 367928003350 ABC transporter signature motif; other site 367928003351 Walker B; other site 367928003352 D-loop; other site 367928003353 H-loop/switch region; other site 367928003354 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 367928003355 Walker A/P-loop; other site 367928003356 ATP binding site [chemical binding]; other site 367928003357 Q-loop/lid; other site 367928003358 ABC transporter signature motif; other site 367928003359 Walker B; other site 367928003360 D-loop; other site 367928003361 H-loop/switch region; other site 367928003362 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 367928003363 Domain of unknown function DUF59; Region: DUF59; cl00941 367928003364 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 367928003365 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 367928003366 Walker A motif; other site 367928003367 Ligase N family; Region: LIGANc; smart00532 367928003368 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 367928003369 nucleotide binding pocket [chemical binding]; other site 367928003370 K-X-D-G motif; other site 367928003371 catalytic site [active] 367928003372 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 367928003373 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 367928003374 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 367928003375 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 367928003376 Dimer interface [polypeptide binding]; other site 367928003377 BRCT sequence motif; other site 367928003378 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 367928003379 binding surface 367928003380 TPR motif; other site 367928003381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928003382 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 367928003383 Walker A/P-loop; other site 367928003384 ATP binding site [chemical binding]; other site 367928003385 ABC transporter signature motif; other site 367928003386 Walker B; other site 367928003387 D-loop; other site 367928003388 H-loop/switch region; other site 367928003389 tyrosine aminotransferase; Provisional; Region: PTZ00433 367928003390 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928003391 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928003392 homodimer interface [polypeptide binding]; other site 367928003393 catalytic residue [active] 367928003394 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 367928003395 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 367928003396 nucleotide binding site [chemical binding]; other site 367928003397 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 367928003398 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 367928003399 Probable Catalytic site; other site 367928003400 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 367928003401 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 367928003402 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 367928003403 Walker A/P-loop; other site 367928003404 ATP binding site [chemical binding]; other site 367928003405 Q-loop/lid; other site 367928003406 ABC transporter signature motif; other site 367928003407 Walker B; other site 367928003408 D-loop; other site 367928003409 H-loop/switch region; other site 367928003410 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 367928003411 Walker A/P-loop; other site 367928003412 ATP binding site [chemical binding]; other site 367928003413 Q-loop/lid; other site 367928003414 ABC transporter signature motif; other site 367928003415 Walker B; other site 367928003416 D-loop; other site 367928003417 H-loop/switch region; other site 367928003418 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 367928003419 Predicted membrane protein [Function unknown]; Region: COG3601 367928003420 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 367928003421 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 367928003422 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928003423 ATP binding site [chemical binding]; other site 367928003424 putative Mg++ binding site [ion binding]; other site 367928003425 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928003426 nucleotide binding region [chemical binding]; other site 367928003427 ATP-binding site [chemical binding]; other site 367928003428 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 367928003429 trimer interface [polypeptide binding]; other site 367928003430 active site 367928003431 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 367928003432 Excalibur calcium-binding domain; Region: Excalibur; smart00894 367928003433 Ion channel; Region: Ion_trans_2; pfam07885 367928003434 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 367928003435 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 367928003436 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 367928003437 NAD binding site [chemical binding]; other site 367928003438 ligand binding site [chemical binding]; other site 367928003439 catalytic site [active] 367928003440 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 367928003441 putative active site [active] 367928003442 dimerization interface [polypeptide binding]; other site 367928003443 putative tRNAtyr binding site [nucleotide binding]; other site 367928003444 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928003445 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928003446 DNA binding site [nucleotide binding] 367928003447 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928003448 ligand binding site [chemical binding]; other site 367928003449 dimerization interface [polypeptide binding]; other site 367928003450 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 367928003451 active site 367928003452 catalytic site [active] 367928003453 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 367928003454 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 367928003455 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 367928003456 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 367928003457 putative active site [active] 367928003458 dimerization interface [polypeptide binding]; other site 367928003459 putative tRNAtyr binding site [nucleotide binding]; other site 367928003460 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 367928003461 GIY-YIG motif/motif A; other site 367928003462 putative active site [active] 367928003463 putative metal binding site [ion binding]; other site 367928003464 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 367928003465 Uncharacterized conserved protein [Function unknown]; Region: COG3410 367928003466 Abi-like protein; Region: Abi_2; pfam07751 367928003467 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 367928003468 active site 367928003469 NTP binding site [chemical binding]; other site 367928003470 metal binding triad [ion binding]; metal-binding site 367928003471 antibiotic binding site [chemical binding]; other site 367928003472 PemK-like protein; Region: PemK; pfam02452 367928003473 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 367928003474 active site 367928003475 metal binding site [ion binding]; metal-binding site 367928003476 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 367928003477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 367928003478 Coenzyme A binding pocket [chemical binding]; other site 367928003479 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 367928003480 Uncharacterized conserved protein [Function unknown]; Region: COG1434 367928003481 putative active site [active] 367928003482 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 367928003483 active site 367928003484 catalytic site [active] 367928003485 substrate binding site [chemical binding]; other site 367928003486 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 367928003487 S-methylmethionine transporter; Provisional; Region: PRK11387 367928003488 trigger factor; Provisional; Region: tig; PRK01490 367928003489 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 367928003490 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 367928003491 DEDDy 3'-5' exonuclease domain of RNase D, WRN, and similar proteins; Region: RNaseD_like; cd06129 367928003492 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 367928003493 catalytic site [active] 367928003494 putative active site [active] 367928003495 putative substrate binding site [chemical binding]; other site 367928003496 HRDC domain; Region: HRDC; pfam00570 367928003497 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 367928003498 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 367928003499 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367928003500 FeS/SAM binding site; other site 367928003501 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 367928003502 Pyruvate formate lyase 1; Region: PFL1; cd01678 367928003503 coenzyme A binding site [chemical binding]; other site 367928003504 active site 367928003505 catalytic residues [active] 367928003506 glycine loop; other site 367928003507 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 367928003508 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 367928003509 homodimer interface [polypeptide binding]; other site 367928003510 NAD binding pocket [chemical binding]; other site 367928003511 ATP binding pocket [chemical binding]; other site 367928003512 Mg binding site [ion binding]; other site 367928003513 active-site loop [active] 367928003514 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 367928003515 M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886 367928003516 metal binding site [ion binding]; metal-binding site 367928003517 dimer interface [polypeptide binding]; other site 367928003518 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 367928003519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928003520 active site 367928003521 motif I; other site 367928003522 motif II; other site 367928003523 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 367928003524 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 367928003525 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 367928003526 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 367928003527 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 367928003528 Walker A/P-loop; other site 367928003529 ATP binding site [chemical binding]; other site 367928003530 Q-loop/lid; other site 367928003531 ABC transporter signature motif; other site 367928003532 Walker B; other site 367928003533 D-loop; other site 367928003534 H-loop/switch region; other site 367928003535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928003536 dimer interface [polypeptide binding]; other site 367928003537 conserved gate region; other site 367928003538 putative PBP binding loops; other site 367928003539 ABC-ATPase subunit interface; other site 367928003540 Yqey-like protein; Region: YqeY; pfam09424 367928003541 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 367928003542 active site 367928003543 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 367928003544 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367928003545 Zn2+ binding site [ion binding]; other site 367928003546 Mg2+ binding site [ion binding]; other site 367928003547 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 367928003548 synthetase active site [active] 367928003549 NTP binding site [chemical binding]; other site 367928003550 metal binding site [ion binding]; metal-binding site 367928003551 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 367928003552 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 367928003553 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 367928003554 trimer interface [polypeptide binding]; other site 367928003555 active site 367928003556 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 367928003557 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 367928003558 Uncharacterized conserved protein [Function unknown]; Region: COG3379 367928003559 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 367928003560 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 367928003561 CAP-like domain; other site 367928003562 active site 367928003563 primary dimer interface [polypeptide binding]; other site 367928003564 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 367928003565 DEAD-like helicases superfamily; Region: DEXDc; smart00487 367928003566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928003567 ATP binding site [chemical binding]; other site 367928003568 putative Mg++ binding site [ion binding]; other site 367928003569 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 367928003570 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928003571 ATP-binding site [chemical binding]; other site 367928003572 DEAD/H associated; Region: DEAD_assoc; pfam08494 367928003573 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928003574 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928003575 putative substrate translocation pore; other site 367928003576 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928003577 Mg2+ binding site [ion binding]; other site 367928003578 G-X-G motif; other site 367928003579 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 367928003580 anchoring element; other site 367928003581 dimer interface [polypeptide binding]; other site 367928003582 ATP binding site [chemical binding]; other site 367928003583 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 367928003584 active site 367928003585 putative metal-binding site [ion binding]; other site 367928003586 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 367928003587 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 367928003588 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 367928003589 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367928003590 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 367928003591 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 367928003592 DNA binding residues [nucleotide binding] 367928003593 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 367928003594 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 367928003595 substrate binding pocket [chemical binding]; other site 367928003596 chain length determination region; other site 367928003597 substrate-Mg2+ binding site; other site 367928003598 catalytic residues [active] 367928003599 aspartate-rich region 1; other site 367928003600 active site lid residues [active] 367928003601 aspartate-rich region 2; other site 367928003602 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 367928003603 Catalytic domain of Protein Kinases; Region: PKc; cd00180 367928003604 active site 367928003605 ATP binding site [chemical binding]; other site 367928003606 substrate binding site [chemical binding]; other site 367928003607 activation loop (A-loop); other site 367928003608 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 367928003609 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 367928003610 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 367928003611 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 367928003612 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 367928003613 putative acyl-acceptor binding pocket; other site 367928003614 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 367928003615 Integrase core domain; Region: rve; pfam00665 367928003616 Integrase core domain; Region: rve_2; pfam13333 367928003617 HTH-like domain; Region: HTH_21; pfam13276 367928003618 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 367928003619 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 367928003620 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 367928003621 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 367928003622 DEAD/DEAH box helicase; Region: DEAD; pfam00270 367928003623 ATP binding site [chemical binding]; other site 367928003624 putative Mg++ binding site [ion binding]; other site 367928003625 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 367928003626 SEC-C motif; Region: SEC-C; pfam02810 367928003627 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 367928003628 30S subunit binding site; other site 367928003629 RecX family; Region: RecX; pfam02631 367928003630 recombinase A; Provisional; Region: recA; PRK09354 367928003631 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 367928003632 hexamer interface [polypeptide binding]; other site 367928003633 Walker A motif; other site 367928003634 ATP binding site [chemical binding]; other site 367928003635 Walker B motif; other site 367928003636 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367928003637 non-specific DNA binding site [nucleotide binding]; other site 367928003638 salt bridge; other site 367928003639 sequence-specific DNA binding site [nucleotide binding]; other site 367928003640 Competence-damaged protein; Region: CinA; pfam02464 367928003641 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 367928003642 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 367928003643 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 367928003644 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 367928003645 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 367928003646 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 367928003647 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 367928003648 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 367928003649 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 367928003650 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 367928003651 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 367928003652 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 367928003653 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367928003654 FeS/SAM binding site; other site 367928003655 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 367928003656 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 367928003657 synthetase active site [active] 367928003658 NTP binding site [chemical binding]; other site 367928003659 metal binding site [ion binding]; metal-binding site 367928003660 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 367928003661 EamA-like transporter family; Region: EamA; pfam00892 367928003662 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 367928003663 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 367928003664 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 367928003665 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928003666 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 367928003667 active site 367928003668 phosphorylation site [posttranslational modification] 367928003669 intermolecular recognition site; other site 367928003670 dimerization interface [polypeptide binding]; other site 367928003671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 367928003672 DNA binding residues [nucleotide binding] 367928003673 dimerization interface [polypeptide binding]; other site 367928003674 Protein of unknown function DUF262; Region: DUF262; pfam03235 367928003675 Uncharacterized conserved protein [Function unknown]; Region: COG1479 367928003676 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 367928003677 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 367928003678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928003679 active site 367928003680 phosphorylation site [posttranslational modification] 367928003681 intermolecular recognition site; other site 367928003682 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 367928003683 DNA binding residues [nucleotide binding] 367928003684 dimerization interface [polypeptide binding]; other site 367928003685 Protein of unknown function (DUF2456); Region: DUF2456; pfam10445 367928003686 Histidine kinase; Region: HisKA_3; pfam07730 367928003687 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 367928003688 ATP binding site [chemical binding]; other site 367928003689 Mg2+ binding site [ion binding]; other site 367928003690 G-X-G motif; other site 367928003691 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 367928003692 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 367928003693 Walker A/P-loop; other site 367928003694 ATP binding site [chemical binding]; other site 367928003695 Q-loop/lid; other site 367928003696 ABC transporter signature motif; other site 367928003697 Walker B; other site 367928003698 D-loop; other site 367928003699 H-loop/switch region; other site 367928003700 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 367928003701 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 367928003702 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 367928003703 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 367928003704 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 367928003705 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 367928003706 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 367928003707 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 367928003708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367928003709 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928003710 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 367928003711 domain linker motif; other site 367928003712 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 367928003713 aconitate hydratase; Validated; Region: PRK09277 367928003714 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 367928003715 substrate binding site [chemical binding]; other site 367928003716 ligand binding site [chemical binding]; other site 367928003717 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 367928003718 substrate binding site [chemical binding]; other site 367928003719 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 367928003720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 367928003721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928003722 motif II; other site 367928003723 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 367928003724 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 367928003725 TRAM domain; Region: TRAM; cl01282 367928003726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367928003727 S-adenosylmethionine binding site [chemical binding]; other site 367928003728 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 367928003729 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 367928003730 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 367928003731 putative active site [active] 367928003732 putative catalytic site [active] 367928003733 putative DNA binding site [nucleotide binding]; other site 367928003734 putative phosphate binding site [ion binding]; other site 367928003735 metal binding site A [ion binding]; metal-binding site 367928003736 putative AP binding site [nucleotide binding]; other site 367928003737 putative metal binding site B [ion binding]; other site 367928003738 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 367928003739 AAA domain; Region: AAA_21; pfam13304 367928003740 Walker A/P-loop; other site 367928003741 ATP binding site [chemical binding]; other site 367928003742 Q-loop/lid; other site 367928003743 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 367928003744 ABC transporter signature motif; other site 367928003745 Walker B; other site 367928003746 D-loop; other site 367928003747 H-loop/switch region; other site 367928003748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 367928003749 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 367928003750 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 367928003751 Walker A/P-loop; other site 367928003752 ATP binding site [chemical binding]; other site 367928003753 Q-loop/lid; other site 367928003754 ABC transporter signature motif; other site 367928003755 Walker B; other site 367928003756 D-loop; other site 367928003757 H-loop/switch region; other site 367928003758 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 367928003759 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 367928003760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928003761 dimer interface [polypeptide binding]; other site 367928003762 conserved gate region; other site 367928003763 putative PBP binding loops; other site 367928003764 ABC-ATPase subunit interface; other site 367928003765 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 367928003766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928003767 dimer interface [polypeptide binding]; other site 367928003768 conserved gate region; other site 367928003769 putative PBP binding loops; other site 367928003770 ABC-ATPase subunit interface; other site 367928003771 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 367928003772 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 367928003773 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 367928003774 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 367928003775 active site 367928003776 DNA binding site [nucleotide binding] 367928003777 Int/Topo IB signature motif; other site 367928003778 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928003779 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 367928003780 Walker A/P-loop; other site 367928003781 ATP binding site [chemical binding]; other site 367928003782 Q-loop/lid; other site 367928003783 ABC transporter signature motif; other site 367928003784 Walker B; other site 367928003785 D-loop; other site 367928003786 H-loop/switch region; other site 367928003787 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928003788 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 367928003789 FtsX-like permease family; Region: FtsX; pfam02687 367928003790 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928003791 FtsX-like permease family; Region: FtsX; pfam02687 367928003792 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 367928003793 prephenate dehydrogenase; Validated; Region: PRK08507 367928003794 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 367928003795 Prephenate dehydratase; Region: PDT; pfam00800 367928003796 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 367928003797 putative L-Phe binding site [chemical binding]; other site 367928003798 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 367928003799 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 367928003800 G1 box; other site 367928003801 putative GEF interaction site [polypeptide binding]; other site 367928003802 GTP/Mg2+ binding site [chemical binding]; other site 367928003803 Switch I region; other site 367928003804 G2 box; other site 367928003805 G3 box; other site 367928003806 Switch II region; other site 367928003807 G4 box; other site 367928003808 G5 box; other site 367928003809 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 367928003810 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 367928003811 benzoate transport; Region: 2A0115; TIGR00895 367928003812 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928003813 putative substrate translocation pore; other site 367928003814 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 367928003815 nudix motif; other site 367928003816 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 367928003817 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 367928003818 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 367928003819 P-loop; other site 367928003820 Magnesium ion binding site [ion binding]; other site 367928003821 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 367928003822 Magnesium ion binding site [ion binding]; other site 367928003823 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 367928003824 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 367928003825 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 367928003826 active site 367928003827 Int/Topo IB signature motif; other site 367928003828 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 367928003829 23S rRNA binding site [nucleotide binding]; other site 367928003830 L21 binding site [polypeptide binding]; other site 367928003831 L13 binding site [polypeptide binding]; other site 367928003832 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 367928003833 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 367928003834 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 367928003835 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 367928003836 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 367928003837 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 367928003838 active site 367928003839 dimer interface [polypeptide binding]; other site 367928003840 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 367928003841 Ligand Binding Site [chemical binding]; other site 367928003842 Molecular Tunnel; other site 367928003843 Thiamine pyrophosphokinase; Region: TPK; cd07995 367928003844 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 367928003845 active site 367928003846 dimerization interface [polypeptide binding]; other site 367928003847 thiamine binding site [chemical binding]; other site 367928003848 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 367928003849 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 367928003850 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 367928003851 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 367928003852 putative deacylase active site [active] 367928003853 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 367928003854 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 367928003855 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 367928003856 active site 367928003857 catalytic residues [active] 367928003858 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 367928003859 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 367928003860 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 367928003861 DNA binding residues [nucleotide binding] 367928003862 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 367928003863 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 367928003864 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367928003865 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 367928003866 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 367928003867 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 367928003868 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 367928003869 aspartate racemase; Region: asp_race; TIGR00035 367928003870 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 367928003871 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367928003872 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 367928003873 proline aminopeptidase P II; Provisional; Region: PRK10879 367928003874 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 367928003875 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 367928003876 active site 367928003877 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 367928003878 nudix motif; other site 367928003879 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 367928003880 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 367928003881 Walker A/P-loop; other site 367928003882 ATP binding site [chemical binding]; other site 367928003883 Q-loop/lid; other site 367928003884 ABC transporter signature motif; other site 367928003885 Walker B; other site 367928003886 D-loop; other site 367928003887 H-loop/switch region; other site 367928003888 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 367928003889 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 367928003890 Walker A/P-loop; other site 367928003891 ATP binding site [chemical binding]; other site 367928003892 Q-loop/lid; other site 367928003893 ABC transporter signature motif; other site 367928003894 Walker B; other site 367928003895 D-loop; other site 367928003896 H-loop/switch region; other site 367928003897 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 367928003898 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 367928003899 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 367928003900 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928003901 dimer interface [polypeptide binding]; other site 367928003902 conserved gate region; other site 367928003903 ABC-ATPase subunit interface; other site 367928003904 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 367928003905 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928003906 dimer interface [polypeptide binding]; other site 367928003907 conserved gate region; other site 367928003908 putative PBP binding loops; other site 367928003909 ABC-ATPase subunit interface; other site 367928003910 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 367928003911 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 367928003912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367928003913 putative DNA binding site [nucleotide binding]; other site 367928003914 Transcriptional regulators [Transcription]; Region: MarR; COG1846 367928003915 putative Zn2+ binding site [ion binding]; other site 367928003916 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 367928003917 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 367928003918 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 367928003919 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 367928003920 putative substrate binding site [chemical binding]; other site 367928003921 putative ATP binding site [chemical binding]; other site 367928003922 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 367928003923 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 367928003924 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 367928003925 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 367928003926 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 367928003927 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367928003928 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 367928003929 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 367928003930 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 367928003931 active site 367928003932 homodimer interface [polypeptide binding]; other site 367928003933 cell division protein FtsW; Region: ftsW; TIGR02614 367928003934 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 367928003935 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367928003936 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 367928003937 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 367928003938 Mg++ binding site [ion binding]; other site 367928003939 putative catalytic motif [active] 367928003940 putative substrate binding site [chemical binding]; other site 367928003941 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 367928003942 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 367928003943 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 367928003944 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 367928003945 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 367928003946 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 367928003947 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 367928003948 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 367928003949 Tfp pilus assembly protein PilV [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilV; COG4967 367928003950 MraW methylase family; Region: Methyltransf_5; cl17771 367928003951 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 367928003952 cell division protein MraZ; Reviewed; Region: PRK00326 367928003953 MraZ protein; Region: MraZ; pfam02381 367928003954 MraZ protein; Region: MraZ; pfam02381 367928003955 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 367928003956 Part of AAA domain; Region: AAA_19; pfam13245 367928003957 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 367928003958 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 367928003959 ligand binding site [chemical binding]; other site 367928003960 NAD binding site [chemical binding]; other site 367928003961 tetramer interface [polypeptide binding]; other site 367928003962 catalytic site [active] 367928003963 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 367928003964 L-serine binding site [chemical binding]; other site 367928003965 ACT domain interface; other site 367928003966 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 367928003967 ATP cone domain; Region: ATP-cone; pfam03477 367928003968 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 367928003969 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 367928003970 LexA repressor; Validated; Region: PRK00215 367928003971 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 367928003972 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 367928003973 Catalytic site [active] 367928003974 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 367928003975 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 367928003976 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 367928003977 NAD binding site [chemical binding]; other site 367928003978 dimer interface [polypeptide binding]; other site 367928003979 substrate binding site [chemical binding]; other site 367928003980 tetramer (dimer of dimers) interface [polypeptide binding]; other site 367928003981 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 367928003982 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 367928003983 HflX GTPase family; Region: HflX; cd01878 367928003984 G1 box; other site 367928003985 GTP/Mg2+ binding site [chemical binding]; other site 367928003986 Switch I region; other site 367928003987 G2 box; other site 367928003988 G3 box; other site 367928003989 Switch II region; other site 367928003990 G4 box; other site 367928003991 G5 box; other site 367928003992 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 367928003993 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367928003994 S-adenosylmethionine binding site [chemical binding]; other site 367928003995 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 367928003996 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928003997 ATP binding site [chemical binding]; other site 367928003998 putative Mg++ binding site [ion binding]; other site 367928003999 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 367928004000 nucleotide binding region [chemical binding]; other site 367928004001 ATP-binding site [chemical binding]; other site 367928004002 Helicase associated domain (HA2); Region: HA2; pfam04408 367928004003 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 367928004004 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 367928004005 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 367928004006 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 367928004007 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 367928004008 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 367928004009 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 367928004010 catalytic residues [active] 367928004011 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 367928004012 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 367928004013 putative active site [active] 367928004014 oxyanion strand; other site 367928004015 catalytic triad [active] 367928004016 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 367928004017 putative active site pocket [active] 367928004018 4-fold oligomerization interface [polypeptide binding]; other site 367928004019 metal binding residues [ion binding]; metal-binding site 367928004020 3-fold/trimer interface [polypeptide binding]; other site 367928004021 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 367928004022 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928004023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928004024 homodimer interface [polypeptide binding]; other site 367928004025 catalytic residue [active] 367928004026 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 367928004027 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 367928004028 NAD binding site [chemical binding]; other site 367928004029 dimerization interface [polypeptide binding]; other site 367928004030 product binding site; other site 367928004031 substrate binding site [chemical binding]; other site 367928004032 zinc binding site [ion binding]; other site 367928004033 catalytic residues [active] 367928004034 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 367928004035 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 367928004036 active site 367928004037 PHP Thumb interface [polypeptide binding]; other site 367928004038 metal binding site [ion binding]; metal-binding site 367928004039 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 367928004040 generic binding surface II; other site 367928004041 generic binding surface I; other site 367928004042 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 367928004043 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 367928004044 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 367928004045 active site 367928004046 lipoprotein signal peptidase; Provisional; Region: PRK14771 367928004047 DivIVA protein; Region: DivIVA; pfam05103 367928004048 DivIVA domain; Region: DivI1A_domain; TIGR03544 367928004049 Protein of unknown function (DUF552); Region: DUF552; pfam04472 367928004050 cell division protein FtsZ; Validated; Region: PRK09330 367928004051 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 367928004052 nucleotide binding site [chemical binding]; other site 367928004053 SulA interaction site; other site 367928004054 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 367928004055 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 367928004056 FMN binding site [chemical binding]; other site 367928004057 active site 367928004058 catalytic residues [active] 367928004059 substrate binding site [chemical binding]; other site 367928004060 glycyl-tRNA synthetase; Provisional; Region: PRK04173 367928004061 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 367928004062 motif 1; other site 367928004063 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 367928004064 active site 367928004065 motif 2; other site 367928004066 motif 3; other site 367928004067 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 367928004068 anticodon binding site; other site 367928004069 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 367928004070 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 367928004071 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 367928004072 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 367928004073 active site 367928004074 catalytic tetrad [active] 367928004075 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 367928004076 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 367928004077 DNA binding residues [nucleotide binding] 367928004078 putative dimer interface [polypeptide binding]; other site 367928004079 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 367928004080 substrate binding site [chemical binding]; other site 367928004081 multimerization interface [polypeptide binding]; other site 367928004082 ATP binding site [chemical binding]; other site 367928004083 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 367928004084 thiamine phosphate binding site [chemical binding]; other site 367928004085 active site 367928004086 pyrophosphate binding site [ion binding]; other site 367928004087 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 367928004088 dimer interface [polypeptide binding]; other site 367928004089 substrate binding site [chemical binding]; other site 367928004090 ATP binding site [chemical binding]; other site 367928004091 Domain of unknown function DUF77; Region: DUF77; pfam01910 367928004092 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928004093 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928004094 DNA binding site [nucleotide binding] 367928004095 domain linker motif; other site 367928004096 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 367928004097 putative dimerization interface [polypeptide binding]; other site 367928004098 putative ligand binding site [chemical binding]; other site 367928004099 galactoside permease; Reviewed; Region: lacY; PRK09528 367928004100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928004101 putative substrate translocation pore; other site 367928004102 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 367928004103 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 367928004104 substrate binding [chemical binding]; other site 367928004105 active site 367928004106 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 367928004107 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 367928004108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928004109 dimer interface [polypeptide binding]; other site 367928004110 conserved gate region; other site 367928004111 putative PBP binding loops; other site 367928004112 ABC-ATPase subunit interface; other site 367928004113 NMT1/THI5 like; Region: NMT1; pfam09084 367928004114 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 367928004115 Inosine-uridine nucleoside N-ribohydrolase [Nucleotide transport and metabolism]; Region: URH1; COG1957 367928004116 active site 367928004117 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 367928004118 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 367928004119 catalytic residue [active] 367928004120 putative FPP diphosphate binding site; other site 367928004121 putative FPP binding hydrophobic cleft; other site 367928004122 dimer interface [polypeptide binding]; other site 367928004123 putative IPP diphosphate binding site; other site 367928004124 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 367928004125 Recombination protein O N terminal; Region: RecO_N; pfam11967 367928004126 Recombination protein O C terminal; Region: RecO_C; pfam02565 367928004127 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 367928004128 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 367928004129 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 367928004130 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 367928004131 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 367928004132 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 367928004133 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 367928004134 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 367928004135 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 367928004136 DivIVA domain; Region: DivI1A_domain; TIGR03544 367928004137 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 367928004138 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 367928004139 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 367928004140 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 367928004141 Part of AAA domain; Region: AAA_19; pfam13245 367928004142 Family description; Region: UvrD_C_2; pfam13538 367928004143 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 367928004144 Phosphotransferase enzyme family; Region: APH; pfam01636 367928004145 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 367928004146 substrate binding site [chemical binding]; other site 367928004147 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 367928004148 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 367928004149 active site 367928004150 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 367928004151 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 367928004152 putative active site [active] 367928004153 redox center [active] 367928004154 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 367928004155 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 367928004156 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 367928004157 glutamate racemase; Provisional; Region: PRK00865 367928004158 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 367928004159 active site 367928004160 nucleophile elbow; other site 367928004161 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 367928004162 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928004163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928004164 homodimer interface [polypeptide binding]; other site 367928004165 catalytic residue [active] 367928004166 Protein of unknown function (DUF805); Region: DUF805; pfam05656 367928004167 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 367928004168 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 367928004169 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 367928004170 catalytic nucleophile [active] 367928004171 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604 367928004172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1729 367928004173 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 367928004174 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 367928004175 DNA-binding interface [nucleotide binding]; DNA binding site 367928004176 Integrase core domain; Region: rve; pfam00665 367928004177 Integrase core domain; Region: rve_3; pfam13683 367928004178 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 367928004179 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928004180 Walker A motif; other site 367928004181 ATP binding site [chemical binding]; other site 367928004182 Walker B motif; other site 367928004183 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 367928004184 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 367928004185 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 367928004186 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 367928004187 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 367928004188 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 367928004189 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 367928004190 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 367928004191 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 367928004192 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 367928004193 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 367928004194 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 367928004195 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 367928004196 HIGH motif; other site 367928004197 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 367928004198 active site 367928004199 KMSKS motif; other site 367928004200 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 367928004201 tRNA binding surface [nucleotide binding]; other site 367928004202 anticodon binding site; other site 367928004203 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 367928004204 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 367928004205 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928004206 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928004207 DNA binding site [nucleotide binding] 367928004208 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 367928004209 putative ligand binding site [chemical binding]; other site 367928004210 putative dimerization interface [polypeptide binding]; other site 367928004211 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367928004212 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367928004213 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 367928004214 Walker A/P-loop; other site 367928004215 ATP binding site [chemical binding]; other site 367928004216 Q-loop/lid; other site 367928004217 ABC transporter signature motif; other site 367928004218 Walker B; other site 367928004219 D-loop; other site 367928004220 H-loop/switch region; other site 367928004221 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367928004222 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367928004223 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928004224 Walker A/P-loop; other site 367928004225 ATP binding site [chemical binding]; other site 367928004226 Q-loop/lid; other site 367928004227 ABC transporter signature motif; other site 367928004228 Walker B; other site 367928004229 D-loop; other site 367928004230 H-loop/switch region; other site 367928004231 Transcriptional regulators [Transcription]; Region: MarR; COG1846 367928004232 MarR family; Region: MarR_2; pfam12802 367928004233 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 367928004234 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 367928004235 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 367928004236 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 367928004237 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367928004238 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928004239 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 367928004240 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 367928004241 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 367928004242 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 367928004243 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928004244 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 367928004245 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367928004246 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928004247 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 367928004248 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 367928004249 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 367928004250 inhibitor binding site; inhibition site 367928004251 active site 367928004252 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 367928004253 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 367928004254 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 367928004255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928004256 putative substrate translocation pore; other site 367928004257 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928004258 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367928004259 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928004260 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 367928004261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928004262 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928004263 putative substrate translocation pore; other site 367928004264 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928004265 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 367928004266 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 367928004267 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 367928004268 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 367928004269 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 367928004270 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 367928004271 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 367928004272 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 367928004273 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 367928004274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 367928004275 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 367928004276 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 367928004277 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 367928004278 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 367928004279 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 367928004280 FeS/SAM binding site; other site 367928004281 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 367928004282 ATP cone domain; Region: ATP-cone; pfam03477 367928004283 Class III ribonucleotide reductase; Region: RNR_III; cd01675 367928004284 effector binding site; other site 367928004285 active site 367928004286 Zn binding site [ion binding]; other site 367928004287 glycine loop; other site 367928004288 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 367928004289 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 367928004290 generic binding surface II; other site 367928004291 generic binding surface I; other site 367928004292 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 367928004293 putative catalytic site [active] 367928004294 putative metal binding site [ion binding]; other site 367928004295 putative phosphate binding site [ion binding]; other site 367928004296 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 367928004297 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 367928004298 P-loop; other site 367928004299 Magnesium ion binding site [ion binding]; other site 367928004300 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 367928004301 exopolyphosphatase; Region: exo_poly_only; TIGR03706 367928004302 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 367928004303 nucleotide binding site [chemical binding]; other site 367928004304 aminotransferase; Validated; Region: PRK07337 367928004305 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 367928004306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928004307 homodimer interface [polypeptide binding]; other site 367928004308 catalytic residue [active] 367928004309 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 367928004310 additional DNA contacts [nucleotide binding]; other site 367928004311 mismatch recognition site; other site 367928004312 active site 367928004313 zinc binding site [ion binding]; other site 367928004314 DNA intercalation site [nucleotide binding]; other site 367928004315 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 367928004316 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 367928004317 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 367928004318 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 367928004319 Family description; Region: UvrD_C_2; pfam13538 367928004320 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 367928004321 HNH endonuclease; Region: HNH_2; pfam13391 367928004322 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 367928004323 putative active site [active] 367928004324 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 367928004325 PLD-like domain; Region: PLDc_2; pfam13091 367928004326 putative active site [active] 367928004327 catalytic site [active] 367928004328 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 367928004329 ATP binding site [chemical binding]; other site 367928004330 putative Mg++ binding site [ion binding]; other site 367928004331 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 367928004332 nucleotide binding region [chemical binding]; other site 367928004333 ATP-binding site [chemical binding]; other site 367928004334 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 367928004335 putative active site [active] 367928004336 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 367928004337 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 367928004338 cofactor binding site; other site 367928004339 DNA binding site [nucleotide binding] 367928004340 substrate interaction site [chemical binding]; other site 367928004341 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 367928004342 Bacterial PH domain; Region: DUF304; pfam03703 367928004343 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 367928004344 active site 367928004345 catalytic site [active] 367928004346 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; pfam09261 367928004347 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 367928004348 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 367928004349 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367928004350 non-specific DNA binding site [nucleotide binding]; other site 367928004351 salt bridge; other site 367928004352 sequence-specific DNA binding site [nucleotide binding]; other site 367928004353 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 367928004354 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367928004355 non-specific DNA binding site [nucleotide binding]; other site 367928004356 salt bridge; other site 367928004357 sequence-specific DNA binding site [nucleotide binding]; other site 367928004358 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 367928004359 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 367928004360 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 367928004361 AAA-like domain; Region: AAA_10; pfam12846 367928004362 Tubby C 2; Region: Tub_2; cl02043 367928004363 Helix-turn-helix domain; Region: HTH_36; pfam13730 367928004364 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 367928004365 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 367928004366 substrate binding pocket [chemical binding]; other site 367928004367 membrane-bound complex binding site; other site 367928004368 hinge residues; other site 367928004369 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 367928004370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928004371 dimer interface [polypeptide binding]; other site 367928004372 conserved gate region; other site 367928004373 putative PBP binding loops; other site 367928004374 ABC-ATPase subunit interface; other site 367928004375 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 367928004376 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 367928004377 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 367928004378 Walker A/P-loop; other site 367928004379 ATP binding site [chemical binding]; other site 367928004380 Q-loop/lid; other site 367928004381 ABC transporter signature motif; other site 367928004382 Walker B; other site 367928004383 D-loop; other site 367928004384 H-loop/switch region; other site 367928004385 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 367928004386 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 367928004387 NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317 367928004388 CHAP domain; Region: CHAP; cl17642 367928004389 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 367928004390 N-acetyl-D-glucosamine binding site [chemical binding]; other site 367928004391 catalytic residue [active] 367928004392 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 367928004393 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 367928004394 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 367928004395 P-loop; other site 367928004396 Magnesium ion binding site [ion binding]; other site 367928004397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367928004398 S-adenosylmethionine binding site [chemical binding]; other site 367928004399 Winged helix-turn helix; Region: HTH_29; pfam13551 367928004400 Helix-turn-helix domain; Region: HTH_28; pfam13518 367928004401 putative transposase OrfB; Reviewed; Region: PHA02517 367928004402 HTH-like domain; Region: HTH_21; pfam13276 367928004403 Integrase core domain; Region: rve; pfam00665 367928004404 Integrase core domain; Region: rve_2; pfam13333 367928004405 LlaJI restriction endonuclease; Region: RE_LlaJI; pfam09563 367928004406 EcoRII C terminal; Region: EcoRII-C; pfam09019 367928004407 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367928004408 non-specific DNA binding site [nucleotide binding]; other site 367928004409 salt bridge; other site 367928004410 sequence-specific DNA binding site [nucleotide binding]; other site 367928004411 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 367928004412 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 367928004413 cofactor binding site; other site 367928004414 DNA binding site [nucleotide binding] 367928004415 substrate interaction site [chemical binding]; other site 367928004416 multiple promoter invertase; Provisional; Region: mpi; PRK13413 367928004417 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 367928004418 catalytic residues [active] 367928004419 catalytic nucleophile [active] 367928004420 Presynaptic Site I dimer interface [polypeptide binding]; other site 367928004421 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 367928004422 Synaptic Flat tetramer interface [polypeptide binding]; other site 367928004423 Synaptic Site I dimer interface [polypeptide binding]; other site 367928004424 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 367928004425 DNA-binding interface [nucleotide binding]; DNA binding site 367928004426 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 367928004427 GIY-YIG motif/motif A; other site 367928004428 putative active site [active] 367928004429 putative metal binding site [ion binding]; other site 367928004430 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 367928004431 beta-galactosidase; Region: BGL; TIGR03356 367928004432 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 367928004433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928004434 dimer interface [polypeptide binding]; other site 367928004435 conserved gate region; other site 367928004436 putative PBP binding loops; other site 367928004437 ABC-ATPase subunit interface; other site 367928004438 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 367928004439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928004440 dimer interface [polypeptide binding]; other site 367928004441 conserved gate region; other site 367928004442 putative PBP binding loops; other site 367928004443 ABC-ATPase subunit interface; other site 367928004444 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 367928004445 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 367928004446 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928004447 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928004448 DNA binding site [nucleotide binding] 367928004449 domain linker motif; other site 367928004450 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928004451 dimerization interface [polypeptide binding]; other site 367928004452 ligand binding site [chemical binding]; other site 367928004453 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 367928004454 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 367928004455 active site 367928004456 catalytic site [active] 367928004457 substrate binding site [chemical binding]; other site 367928004458 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 367928004459 active site 367928004460 substrate binding site [chemical binding]; other site 367928004461 catalytic site [active] 367928004462 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 367928004463 active site 367928004464 catalytic residues [active] 367928004465 metal binding site [ion binding]; metal-binding site 367928004466 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 367928004467 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 367928004468 active site 367928004469 substrate binding site [chemical binding]; other site 367928004470 metal binding site [ion binding]; metal-binding site 367928004471 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 367928004472 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 367928004473 Zn binding site [ion binding]; other site 367928004474 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 367928004475 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 367928004476 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 367928004477 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 367928004478 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 367928004479 dimer interface [polypeptide binding]; other site 367928004480 active site 367928004481 catalytic residue [active] 367928004482 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 367928004483 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928004484 putative substrate translocation pore; other site 367928004485 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 367928004486 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 367928004487 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 367928004488 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 367928004489 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 367928004490 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 367928004491 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 367928004492 Soluble P-type ATPase [General function prediction only]; Region: COG4087 367928004493 Uncharacterized conserved protein [Function unknown]; Region: COG3350 367928004494 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 367928004495 putative homodimer interface [polypeptide binding]; other site 367928004496 putative homotetramer interface [polypeptide binding]; other site 367928004497 putative allosteric switch controlling residues; other site 367928004498 putative metal binding site [ion binding]; other site 367928004499 putative homodimer-homodimer interface [polypeptide binding]; other site 367928004500 dihydrodipicolinate reductase; Provisional; Region: PRK00048 367928004501 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 367928004502 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 367928004503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928004504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928004505 Part of AAA domain; Region: AAA_19; pfam13245 367928004506 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 367928004507 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 367928004508 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 367928004509 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 367928004510 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 367928004511 Double zinc ribbon; Region: DZR; pfam12773 367928004512 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 367928004513 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 367928004514 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 367928004515 Catalytic domain of Protein Kinases; Region: PKc; cd00180 367928004516 active site 367928004517 ATP binding site [chemical binding]; other site 367928004518 substrate binding site [chemical binding]; other site 367928004519 activation loop (A-loop); other site 367928004520 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 367928004521 Interdomain contacts; other site 367928004522 Cytokine receptor motif; other site 367928004523 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 367928004524 Interdomain contacts; other site 367928004525 Cytokine receptor motif; other site 367928004526 MoxR-like ATPases [General function prediction only]; Region: COG0714 367928004527 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928004528 Walker A motif; other site 367928004529 ATP binding site [chemical binding]; other site 367928004530 Walker B motif; other site 367928004531 arginine finger; other site 367928004532 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 367928004533 Protein of unknown function DUF58; Region: DUF58; pfam01882 367928004534 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 367928004535 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 367928004536 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 367928004537 active site 367928004538 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 367928004539 phosphopeptide binding site; other site 367928004540 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 367928004541 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 367928004542 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 367928004543 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 367928004544 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 367928004545 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 367928004546 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 367928004547 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 367928004548 DNA binding site [nucleotide binding] 367928004549 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 367928004550 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 367928004551 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 367928004552 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 367928004553 RPB1 interaction site [polypeptide binding]; other site 367928004554 RPB10 interaction site [polypeptide binding]; other site 367928004555 RPB11 interaction site [polypeptide binding]; other site 367928004556 RPB3 interaction site [polypeptide binding]; other site 367928004557 RPB12 interaction site [polypeptide binding]; other site 367928004558 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 367928004559 endonuclease III; Region: ENDO3c; smart00478 367928004560 minor groove reading motif; other site 367928004561 helix-hairpin-helix signature motif; other site 367928004562 substrate binding pocket [chemical binding]; other site 367928004563 active site 367928004564 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 367928004565 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 367928004566 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 367928004567 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 367928004568 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 367928004569 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 367928004570 substrate binding [chemical binding]; other site 367928004571 active site 367928004572 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928004573 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928004574 DNA binding site [nucleotide binding] 367928004575 domain linker motif; other site 367928004576 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 367928004577 putative dimerization interface [polypeptide binding]; other site 367928004578 putative ligand binding site [chemical binding]; other site 367928004579 Protein of unknown function, DUF624; Region: DUF624; pfam04854 367928004580 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 367928004581 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928004582 dimer interface [polypeptide binding]; other site 367928004583 conserved gate region; other site 367928004584 putative PBP binding loops; other site 367928004585 ABC-ATPase subunit interface; other site 367928004586 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 367928004587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928004588 dimer interface [polypeptide binding]; other site 367928004589 conserved gate region; other site 367928004590 putative PBP binding loops; other site 367928004591 ABC-ATPase subunit interface; other site 367928004592 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 367928004593 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 367928004594 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 367928004595 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 367928004596 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 367928004597 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 367928004598 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 367928004599 dimer interface [polypeptide binding]; other site 367928004600 active site 367928004601 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 367928004602 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 367928004603 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 367928004604 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 367928004605 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 367928004606 active site 367928004607 catalytic residues [active] 367928004608 FMN binding site [chemical binding]; other site 367928004609 quinone interaction residues [chemical binding]; other site 367928004610 substrate binding site [chemical binding]; other site 367928004611 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 367928004612 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 367928004613 active site 367928004614 FMN binding site [chemical binding]; other site 367928004615 substrate binding site [chemical binding]; other site 367928004616 homotetramer interface [polypeptide binding]; other site 367928004617 catalytic residue [active] 367928004618 Transglycosylase; Region: Transgly; pfam00912 367928004619 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 367928004620 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 367928004621 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 367928004622 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 367928004623 ligand binding site [chemical binding]; other site 367928004624 flexible hinge region; other site 367928004625 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 367928004626 putative switch regulator; other site 367928004627 non-specific DNA interactions [nucleotide binding]; other site 367928004628 DNA binding site [nucleotide binding] 367928004629 sequence specific DNA binding site [nucleotide binding]; other site 367928004630 putative cAMP binding site [chemical binding]; other site 367928004631 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 367928004632 TM2 domain; Region: TM2; pfam05154 367928004633 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 367928004634 tartrate dehydrogenase; Region: TTC; TIGR02089 367928004635 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 367928004636 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 367928004637 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 367928004638 Uncharacterized conserved protein [Function unknown]; Region: COG4850 367928004639 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 367928004640 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 367928004641 lipoyl attachment site [posttranslational modification]; other site 367928004642 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 367928004643 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 367928004644 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 367928004645 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 367928004646 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 367928004647 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 367928004648 putative NADH binding site [chemical binding]; other site 367928004649 putative active site [active] 367928004650 nudix motif; other site 367928004651 putative metal binding site [ion binding]; other site 367928004652 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 367928004653 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 367928004654 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 367928004655 catalytic residues [active] 367928004656 Domain of unknown function (DUF348); Region: DUF348; pfam03990 367928004657 G5 domain; Region: G5; pfam07501 367928004658 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 367928004659 N-acetyl-D-glucosamine binding site [chemical binding]; other site 367928004660 catalytic residue [active] 367928004661 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 367928004662 putative active site [active] 367928004663 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 367928004664 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367928004665 non-specific DNA binding site [nucleotide binding]; other site 367928004666 salt bridge; other site 367928004667 sequence-specific DNA binding site [nucleotide binding]; other site 367928004668 Low molecular weight phosphatase family; Region: LMWPc; cd00115 367928004669 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 367928004670 active site 367928004671 Chain length determinant protein; Region: Wzz; cl15801 367928004672 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 367928004673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 367928004674 hypothetical protein; Provisional; Region: PRK11770 367928004675 Domain of unknown function (DUF307); Region: DUF307; pfam03733 367928004676 Domain of unknown function (DUF307); Region: DUF307; pfam03733 367928004677 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 367928004678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 367928004679 non-specific DNA binding site [nucleotide binding]; other site 367928004680 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 367928004681 salt bridge; other site 367928004682 sequence-specific DNA binding site [nucleotide binding]; other site 367928004683 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 367928004684 Transposase, Mutator family; Region: Transposase_mut; pfam00872 367928004685 MULE transposase domain; Region: MULE; pfam10551 367928004686 Abi-like protein; Region: Abi_2; pfam07751 367928004687 HTH-like domain; Region: HTH_21; pfam13276 367928004688 Integrase core domain; Region: rve; pfam00665 367928004689 putative transposase OrfB; Reviewed; Region: PHA02517 367928004690 HTH-like domain; Region: HTH_21; pfam13276 367928004691 Integrase core domain; Region: rve; pfam00665 367928004692 Integrase core domain; Region: rve_3; pfam13683 367928004693 putative transposase OrfB; Reviewed; Region: PHA02517 367928004694 HTH-like domain; Region: HTH_21; pfam13276 367928004695 Integrase core domain; Region: rve; pfam00665 367928004696 Integrase core domain; Region: rve_2; pfam13333 367928004697 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 367928004698 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 367928004699 DNA-binding interface [nucleotide binding]; DNA binding site 367928004700 Integrase core domain; Region: rve; pfam00665 367928004701 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 367928004702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928004703 Walker A motif; other site 367928004704 ATP binding site [chemical binding]; other site 367928004705 Walker B motif; other site 367928004706 arginine finger; other site 367928004707 Transposase; Region: HTH_Tnp_1; pfam01527 367928004708 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 367928004709 Acyltransferase family; Region: Acyl_transf_3; pfam01757 367928004710 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 367928004711 active site 367928004712 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 367928004713 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 367928004714 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 367928004715 active site 367928004716 substrate binding site [chemical binding]; other site 367928004717 trimer interface [polypeptide binding]; other site 367928004718 CoA binding site [chemical binding]; other site 367928004719 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 367928004720 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 367928004721 active site 367928004722 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 367928004723 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 367928004724 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 367928004725 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367928004726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 367928004727 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 367928004728 putative ADP-binding pocket [chemical binding]; other site 367928004729 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 367928004730 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 367928004731 Bacterial sugar transferase; Region: Bac_transf; pfam02397 367928004732 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 367928004733 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 367928004734 putative catalytic site [active] 367928004735 putative metal binding site [ion binding]; other site 367928004736 putative phosphate binding site [ion binding]; other site 367928004737 Fic family protein [Function unknown]; Region: COG3177 367928004738 Fic/DOC family; Region: Fic; pfam02661 367928004739 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928004740 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928004741 putative substrate translocation pore; other site 367928004742 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928004743 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 367928004744 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 367928004745 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 367928004746 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 367928004747 active site 367928004748 catalytic tetrad [active] 367928004749 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 367928004750 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928004751 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928004752 DNA binding site [nucleotide binding] 367928004753 domain linker motif; other site 367928004754 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928004755 ligand binding site [chemical binding]; other site 367928004756 dimerization interface [polypeptide binding]; other site 367928004757 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 367928004758 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 367928004759 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 367928004760 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 367928004761 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 367928004762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928004763 dimer interface [polypeptide binding]; other site 367928004764 conserved gate region; other site 367928004765 putative PBP binding loops; other site 367928004766 ABC-ATPase subunit interface; other site 367928004767 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928004768 dimer interface [polypeptide binding]; other site 367928004769 conserved gate region; other site 367928004770 putative PBP binding loops; other site 367928004771 ABC-ATPase subunit interface; other site 367928004772 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 367928004773 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 367928004774 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 367928004775 predicted active site [active] 367928004776 catalytic triad [active] 367928004777 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 367928004778 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 367928004779 active site 367928004780 multimer interface [polypeptide binding]; other site 367928004781 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 367928004782 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367928004783 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928004784 Walker A/P-loop; other site 367928004785 ATP binding site [chemical binding]; other site 367928004786 Q-loop/lid; other site 367928004787 ABC transporter signature motif; other site 367928004788 Walker B; other site 367928004789 D-loop; other site 367928004790 H-loop/switch region; other site 367928004791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928004792 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 367928004793 Walker A/P-loop; other site 367928004794 ATP binding site [chemical binding]; other site 367928004795 Q-loop/lid; other site 367928004796 ABC transporter signature motif; other site 367928004797 Walker B; other site 367928004798 D-loop; other site 367928004799 H-loop/switch region; other site 367928004800 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 367928004801 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 367928004802 acyl-activating enzyme (AAE) consensus motif; other site 367928004803 putative AMP binding site [chemical binding]; other site 367928004804 putative active site [active] 367928004805 putative CoA binding site [chemical binding]; other site 367928004806 L-arabinose isomerase; Provisional; Region: PRK02929 367928004807 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 367928004808 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 367928004809 trimer interface [polypeptide binding]; other site 367928004810 putative substrate binding site [chemical binding]; other site 367928004811 putative metal binding site [ion binding]; other site 367928004812 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 367928004813 intersubunit interface [polypeptide binding]; other site 367928004814 active site 367928004815 Zn2+ binding site [ion binding]; other site 367928004816 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 367928004817 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 367928004818 putative N- and C-terminal domain interface [polypeptide binding]; other site 367928004819 putative active site [active] 367928004820 MgATP binding site [chemical binding]; other site 367928004821 catalytic site [active] 367928004822 metal binding site [ion binding]; metal-binding site 367928004823 putative carbohydrate binding site [chemical binding]; other site 367928004824 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928004825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928004826 DNA binding site [nucleotide binding] 367928004827 domain linker motif; other site 367928004828 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 367928004829 ligand binding site [chemical binding]; other site 367928004830 dimerization interface (open form) [polypeptide binding]; other site 367928004831 dimerization interface (closed form) [polypeptide binding]; other site 367928004832 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 367928004833 putative active site [active] 367928004834 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 367928004835 dimer interface [polypeptide binding]; other site 367928004836 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 367928004837 nudix motif; other site 367928004838 homoserine kinase; Provisional; Region: PRK01212 367928004839 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 367928004840 homoserine dehydrogenase; Provisional; Region: PRK06349 367928004841 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 367928004842 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 367928004843 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 367928004844 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 367928004845 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 367928004846 catalytic residue [active] 367928004847 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 367928004848 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 367928004849 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 367928004850 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 367928004851 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367928004852 active site 367928004853 HIGH motif; other site 367928004854 nucleotide binding site [chemical binding]; other site 367928004855 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 367928004856 KMSK motif region; other site 367928004857 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 367928004858 tRNA binding surface [nucleotide binding]; other site 367928004859 anticodon binding site; other site 367928004860 S-methylmethionine transporter; Provisional; Region: PRK11387 367928004861 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 367928004862 homotrimer interaction site [polypeptide binding]; other site 367928004863 putative active site [active] 367928004864 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 367928004865 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 367928004866 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 367928004867 hypothetical protein; Provisional; Region: PRK03298 367928004868 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 367928004869 gamma subunit interface [polypeptide binding]; other site 367928004870 epsilon subunit interface [polypeptide binding]; other site 367928004871 LBP interface [polypeptide binding]; other site 367928004872 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 367928004873 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 367928004874 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 367928004875 alpha subunit interaction interface [polypeptide binding]; other site 367928004876 Walker A motif; other site 367928004877 ATP binding site [chemical binding]; other site 367928004878 Walker B motif; other site 367928004879 inhibitor binding site; inhibition site 367928004880 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 367928004881 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 367928004882 core domain interface [polypeptide binding]; other site 367928004883 delta subunit interface [polypeptide binding]; other site 367928004884 epsilon subunit interface [polypeptide binding]; other site 367928004885 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 367928004886 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 367928004887 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 367928004888 beta subunit interaction interface [polypeptide binding]; other site 367928004889 Walker A motif; other site 367928004890 ATP binding site [chemical binding]; other site 367928004891 Walker B motif; other site 367928004892 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 367928004893 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 367928004894 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 367928004895 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 367928004896 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 367928004897 ATP synthase subunit C; Region: ATP-synt_C; cl00466 367928004898 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 367928004899 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 367928004900 homoserine O-succinyltransferase; Provisional; Region: PRK05368 367928004901 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 367928004902 proposed active site lysine [active] 367928004903 conserved cys residue [active] 367928004904 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 367928004905 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 367928004906 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 367928004907 active site 367928004908 catalytic site [active] 367928004909 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928004910 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928004911 Walker A/P-loop; other site 367928004912 ATP binding site [chemical binding]; other site 367928004913 Q-loop/lid; other site 367928004914 ABC transporter signature motif; other site 367928004915 Walker B; other site 367928004916 D-loop; other site 367928004917 H-loop/switch region; other site 367928004918 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 367928004919 transcriptional regulator NarP; Provisional; Region: PRK10403 367928004920 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928004921 active site 367928004922 phosphorylation site [posttranslational modification] 367928004923 intermolecular recognition site; other site 367928004924 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 367928004925 DNA binding residues [nucleotide binding] 367928004926 dimerization interface [polypeptide binding]; other site 367928004927 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 367928004928 Histidine kinase; Region: HisKA_3; pfam07730 367928004929 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 367928004930 dimer interface [polypeptide binding]; other site 367928004931 substrate binding site [chemical binding]; other site 367928004932 metal binding sites [ion binding]; metal-binding site 367928004933 Predicted membrane protein [Function unknown]; Region: COG1971 367928004934 Domain of unknown function DUF; Region: DUF204; pfam02659 367928004935 Domain of unknown function DUF; Region: DUF204; pfam02659 367928004936 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 367928004937 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 367928004938 DNA binding site [nucleotide binding] 367928004939 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 367928004940 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 367928004941 minor groove reading motif; other site 367928004942 helix-hairpin-helix signature motif; other site 367928004943 substrate binding pocket [chemical binding]; other site 367928004944 active site 367928004945 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 367928004946 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 367928004947 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 367928004948 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 367928004949 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367928004950 active site 367928004951 HIGH motif; other site 367928004952 nucleotide binding site [chemical binding]; other site 367928004953 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 367928004954 active site 367928004955 KMSKS motif; other site 367928004956 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 367928004957 tRNA binding surface [nucleotide binding]; other site 367928004958 anticodon binding site; other site 367928004959 chorismate mutase; Provisional; Region: PRK09239 367928004960 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 367928004961 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 367928004962 putative DNA binding site [nucleotide binding]; other site 367928004963 putative Zn2+ binding site [ion binding]; other site 367928004964 AsnC family; Region: AsnC_trans_reg; pfam01037 367928004965 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 367928004966 transcription termination factor Rho; Provisional; Region: PRK12608 367928004967 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 367928004968 RNA binding site [nucleotide binding]; other site 367928004969 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 367928004970 Walker A motif; other site 367928004971 ATP binding site [chemical binding]; other site 367928004972 Walker B motif; other site 367928004973 hypothetical protein; Provisional; Region: PRK07208 367928004974 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 367928004975 UDP-galactopyranose mutase; Region: GLF; pfam03275 367928004976 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 367928004977 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 367928004978 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 367928004979 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 367928004980 GatB domain; Region: GatB_Yqey; pfam02637 367928004981 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 367928004982 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 367928004983 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 367928004984 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 367928004985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 367928004986 active site 367928004987 RmuC family; Region: RmuC; pfam02646 367928004988 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 367928004989 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 367928004990 Clp amino terminal domain; Region: Clp_N; pfam02861 367928004991 Clp amino terminal domain; Region: Clp_N; pfam02861 367928004992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928004993 Walker A motif; other site 367928004994 ATP binding site [chemical binding]; other site 367928004995 Walker B motif; other site 367928004996 arginine finger; other site 367928004997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 367928004998 Walker A motif; other site 367928004999 ATP binding site [chemical binding]; other site 367928005000 Walker B motif; other site 367928005001 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 367928005002 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 367928005003 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 367928005004 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 367928005005 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 367928005006 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 367928005007 metal ion-dependent adhesion site (MIDAS); other site 367928005008 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 367928005009 active site 367928005010 catalytic site [active] 367928005011 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 367928005012 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 367928005013 catalytic residue [active] 367928005014 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 367928005015 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 367928005016 active site 367928005017 HIGH motif; other site 367928005018 nucleotide binding site [chemical binding]; other site 367928005019 active site 367928005020 KMSKS motif; other site 367928005021 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 367928005022 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 367928005023 amphipathic channel; other site 367928005024 Asn-Pro-Ala signature motifs; other site 367928005025 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 367928005026 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 367928005027 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 367928005028 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 367928005029 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 367928005030 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 367928005031 dimer interface [polypeptide binding]; other site 367928005032 ssDNA binding site [nucleotide binding]; other site 367928005033 tetramer (dimer of dimers) interface [polypeptide binding]; other site 367928005034 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 367928005035 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 367928005036 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 367928005037 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 367928005038 active site 367928005039 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 367928005040 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 367928005041 substrate binding site [chemical binding]; other site 367928005042 dimer interface [polypeptide binding]; other site 367928005043 ATP binding site [chemical binding]; other site 367928005044 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 367928005045 active site 367928005046 transcriptional repressor RbsR; Provisional; Region: PRK10423 367928005047 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928005048 DNA binding site [nucleotide binding] 367928005049 domain linker motif; other site 367928005050 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928005051 dimerization interface [polypeptide binding]; other site 367928005052 ligand binding site [chemical binding]; other site 367928005053 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 367928005054 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 367928005055 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928005056 putative substrate translocation pore; other site 367928005057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928005058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928005059 putative substrate translocation pore; other site 367928005060 FOG: CBS domain [General function prediction only]; Region: COG0517 367928005061 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 367928005062 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 367928005063 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 367928005064 NAD binding site [chemical binding]; other site 367928005065 substrate binding site [chemical binding]; other site 367928005066 homodimer interface [polypeptide binding]; other site 367928005067 active site 367928005068 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 367928005069 Sulfatase; Region: Sulfatase; pfam00884 367928005070 putative glycosyl transferase; Provisional; Region: PRK10073 367928005071 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 367928005072 active site 367928005073 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 367928005074 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 367928005075 active site 367928005076 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 367928005077 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 367928005078 Walker A/P-loop; other site 367928005079 ATP binding site [chemical binding]; other site 367928005080 Q-loop/lid; other site 367928005081 ABC transporter signature motif; other site 367928005082 Walker B; other site 367928005083 D-loop; other site 367928005084 H-loop/switch region; other site 367928005085 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 367928005086 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 367928005087 Rhamnan synthesis protein F; Region: RgpF; pfam05045 367928005088 Acyltransferase family; Region: Acyl_transf_3; pfam01757 367928005089 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 367928005090 Ligand binding site; other site 367928005091 Putative Catalytic site; other site 367928005092 DXD motif; other site 367928005093 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 367928005094 extended (e) SDRs; Region: SDR_e; cd08946 367928005095 NAD(P) binding site [chemical binding]; other site 367928005096 active site 367928005097 substrate binding site [chemical binding]; other site 367928005098 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 367928005099 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 367928005100 NAD binding site [chemical binding]; other site 367928005101 substrate binding site [chemical binding]; other site 367928005102 homodimer interface [polypeptide binding]; other site 367928005103 active site 367928005104 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 367928005105 dTDP-4-dehydrorhamnose reductase [Cell envelope biogenesis, outer membrane]; Region: RfbD; COG1091 367928005106 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 367928005107 NADP binding site [chemical binding]; other site 367928005108 active site 367928005109 putative substrate binding site [chemical binding]; other site 367928005110 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 367928005111 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 367928005112 substrate binding site; other site 367928005113 tetramer interface; other site 367928005114 Acyltransferase family; Region: Acyl_transf_3; pfam01757 367928005115 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 367928005116 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 367928005117 active site 367928005118 Domain of unknown function (DUF303); Region: DUF303; pfam03629 367928005119 Autophagy protein Apg6; Region: APG6; pfam04111 367928005120 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 367928005121 FtsX-like permease family; Region: FtsX; pfam02687 367928005122 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928005123 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 367928005124 ATP binding site [chemical binding]; other site 367928005125 Q-loop/lid; other site 367928005126 ABC transporter signature motif; other site 367928005127 Walker B; other site 367928005128 D-loop; other site 367928005129 H-loop/switch region; other site 367928005130 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 367928005131 Zn2+ binding site [ion binding]; other site 367928005132 Mg2+ binding site [ion binding]; other site 367928005133 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 367928005134 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 367928005135 putative active site [active] 367928005136 putative dimer interface [polypeptide binding]; other site 367928005137 K+ potassium transporter; Region: K_trans; pfam02705 367928005138 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 367928005139 active site 367928005140 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 367928005141 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 367928005142 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 367928005143 alpha-galactosidase; Region: PLN02808; cl17638 367928005144 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928005145 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928005146 DNA binding site [nucleotide binding] 367928005147 domain linker motif; other site 367928005148 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928005149 dimerization interface [polypeptide binding]; other site 367928005150 ligand binding site [chemical binding]; other site 367928005151 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 367928005152 active site 367928005153 Melibiase; Region: Melibiase; pfam02065 367928005154 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 367928005155 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 367928005156 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367928005157 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367928005158 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 367928005159 Walker A/P-loop; other site 367928005160 ATP binding site [chemical binding]; other site 367928005161 Q-loop/lid; other site 367928005162 ABC transporter signature motif; other site 367928005163 Walker B; other site 367928005164 D-loop; other site 367928005165 H-loop/switch region; other site 367928005166 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 367928005167 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 367928005168 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 367928005169 Walker A/P-loop; other site 367928005170 ATP binding site [chemical binding]; other site 367928005171 Q-loop/lid; other site 367928005172 ABC transporter signature motif; other site 367928005173 Walker B; other site 367928005174 D-loop; other site 367928005175 H-loop/switch region; other site 367928005176 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 367928005177 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 367928005178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928005179 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 367928005180 putative substrate translocation pore; other site 367928005181 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928005182 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 367928005183 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 367928005184 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 367928005185 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 367928005186 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 367928005187 active site 367928005188 HIGH motif; other site 367928005189 KMSKS motif; other site 367928005190 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 367928005191 tRNA binding surface [nucleotide binding]; other site 367928005192 anticodon binding site; other site 367928005193 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 367928005194 Predicted methyltransferases [General function prediction only]; Region: COG0313 367928005195 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 367928005196 putative SAM binding site [chemical binding]; other site 367928005197 putative homodimer interface [polypeptide binding]; other site 367928005198 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 367928005199 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 367928005200 motif I; other site 367928005201 active site 367928005202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928005203 motif II; other site 367928005204 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 367928005205 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 367928005206 DNA binding residues [nucleotide binding] 367928005207 DnaJ-class molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: CbpA; COG2214 367928005208 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 367928005209 HSP70 interaction site [polypeptide binding]; other site 367928005210 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 367928005211 substrate binding site [polypeptide binding]; other site 367928005212 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 367928005213 dimer interface [polypeptide binding]; other site 367928005214 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 367928005215 GrpE; Region: GrpE; pfam01025 367928005216 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 367928005217 dimer interface [polypeptide binding]; other site 367928005218 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 367928005219 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 367928005220 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 367928005221 nucleotide binding site [chemical binding]; other site 367928005222 alkaline phosphatase; Provisional; Region: PRK10518 367928005223 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 367928005224 active site 367928005225 dimer interface [polypeptide binding]; other site 367928005226 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 367928005227 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 367928005228 active site 367928005229 catalytic site [active] 367928005230 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 367928005231 domain interaction interfaces [polypeptide binding]; other site 367928005232 Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking; Region: RasGEF; cl02485 367928005233 Fic/DOC family; Region: Fic; cl00960 367928005234 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928005235 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928005236 DNA binding site [nucleotide binding] 367928005237 domain linker motif; other site 367928005238 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928005239 ligand binding site [chemical binding]; other site 367928005240 dimerization interface [polypeptide binding]; other site 367928005241 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 367928005242 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 367928005243 motif II; other site 367928005244 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 367928005245 Ca binding site [ion binding]; other site 367928005246 active site 367928005247 catalytic site [active] 367928005248 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 367928005249 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 367928005250 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 367928005251 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 367928005252 active site 367928005253 catalytic site [active] 367928005254 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 367928005255 Protein of unknown function, DUF624; Region: DUF624; pfam04854 367928005256 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 367928005257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928005258 dimer interface [polypeptide binding]; other site 367928005259 conserved gate region; other site 367928005260 putative PBP binding loops; other site 367928005261 ABC-ATPase subunit interface; other site 367928005262 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 367928005263 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928005264 dimer interface [polypeptide binding]; other site 367928005265 conserved gate region; other site 367928005266 putative PBP binding loops; other site 367928005267 ABC-ATPase subunit interface; other site 367928005268 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928005269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928005270 DNA binding site [nucleotide binding] 367928005271 domain linker motif; other site 367928005272 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928005273 ligand binding site [chemical binding]; other site 367928005274 dimerization interface [polypeptide binding]; other site 367928005275 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 367928005276 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928005277 catalytic core [active] 367928005278 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 367928005279 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 367928005280 dimer interface [polypeptide binding]; other site 367928005281 FMN binding site [chemical binding]; other site 367928005282 NADPH bind site [chemical binding]; other site 367928005283 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 367928005284 threonine dehydratase; Provisional; Region: PRK08198 367928005285 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 367928005286 tetramer interface [polypeptide binding]; other site 367928005287 pyridoxal 5'-phosphate binding site [chemical binding]; other site 367928005288 catalytic residue [active] 367928005289 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 367928005290 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 367928005291 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 367928005292 Ca binding site [ion binding]; other site 367928005293 active site 367928005294 catalytic site [active] 367928005295 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 367928005296 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928005297 dimer interface [polypeptide binding]; other site 367928005298 conserved gate region; other site 367928005299 putative PBP binding loops; other site 367928005300 ABC-ATPase subunit interface; other site 367928005301 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 367928005302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928005303 dimer interface [polypeptide binding]; other site 367928005304 conserved gate region; other site 367928005305 putative PBP binding loops; other site 367928005306 ABC-ATPase subunit interface; other site 367928005307 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 367928005308 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 367928005309 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 367928005310 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 367928005311 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 367928005312 Melibiase; Region: Melibiase; pfam02065 367928005313 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 367928005314 nucleoside/Zn binding site; other site 367928005315 dimer interface [polypeptide binding]; other site 367928005316 catalytic motif [active] 367928005317 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 367928005318 Serine hydrolase (FSH1); Region: FSH1; pfam03959 367928005319 Predicted esterase [General function prediction only]; Region: COG0400 367928005320 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 367928005321 trimer interface [polypeptide binding]; other site 367928005322 active site 367928005323 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 367928005324 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 367928005325 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 367928005326 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 367928005327 Soluble P-type ATPase [General function prediction only]; Region: COG4087 367928005328 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 367928005329 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 367928005330 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 367928005331 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 367928005332 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 367928005333 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 367928005334 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 367928005335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928005336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928005337 DNA binding site [nucleotide binding] 367928005338 domain linker motif; other site 367928005339 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 367928005340 dimerization interface [polypeptide binding]; other site 367928005341 ligand binding site [chemical binding]; other site 367928005342 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 367928005343 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 367928005344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928005345 dimer interface [polypeptide binding]; other site 367928005346 conserved gate region; other site 367928005347 putative PBP binding loops; other site 367928005348 ABC-ATPase subunit interface; other site 367928005349 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 367928005350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 367928005351 dimer interface [polypeptide binding]; other site 367928005352 conserved gate region; other site 367928005353 putative PBP binding loops; other site 367928005354 ABC-ATPase subunit interface; other site 367928005355 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 367928005356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928005357 Major Facilitator Superfamily; Region: MFS_1; pfam07690 367928005358 putative substrate translocation pore; other site 367928005359 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 367928005360 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 367928005361 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 367928005362 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 367928005363 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 367928005364 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 367928005365 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 367928005366 Walker A/P-loop; other site 367928005367 ATP binding site [chemical binding]; other site 367928005368 Q-loop/lid; other site 367928005369 ABC transporter signature motif; other site 367928005370 Walker B; other site 367928005371 D-loop; other site 367928005372 H-loop/switch region; other site 367928005373 TOBE domain; Region: TOBE_2; pfam08402 367928005374 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 367928005375 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 367928005376 active site 367928005377 phosphorylation site [posttranslational modification] 367928005378 intermolecular recognition site; other site 367928005379 dimerization interface [polypeptide binding]; other site 367928005380 LytTr DNA-binding domain; Region: LytTR; smart00850 367928005381 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 367928005382 ATP binding site [chemical binding]; other site 367928005383 Mg2+ binding site [ion binding]; other site 367928005384 G-X-G motif; other site 367928005385 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 367928005386 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 367928005387 putative ion selectivity filter; other site 367928005388 putative pore gating glutamate residue; other site 367928005389 Probable beta-xylosidase; Provisional; Region: PLN03080 367928005390 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 367928005391 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 367928005392 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 367928005393 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 367928005394 putative active site [active] 367928005395 putative catalytic site [active] 367928005396 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 367928005397 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 367928005398 active site 367928005399 dimer interface [polypeptide binding]; other site 367928005400 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 367928005401 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 367928005402 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 367928005403 large subunit ribosomal protein LP2; Provisional; Region: PLN00138 367928005404 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 367928005405 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 367928005406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 367928005407 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 367928005408 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 367928005409 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 367928005410 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 367928005411 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 367928005412 Transcriptional regulators [Transcription]; Region: PurR; COG1609 367928005413 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 367928005414 DNA binding site [nucleotide binding] 367928005415 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 367928005416 putative ligand binding site [chemical binding]; other site 367928005417 putative dimerization interface [polypeptide binding]; other site 367928005418 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 367928005419 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 367928005420 putative acetyltransferase; Provisional; Region: PRK03624 367928005421 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 367928005422 Coenzyme A binding pocket [chemical binding]; other site 367928005423 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_4; pfam14281 367928005424 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 367928005425 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 367928005426 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 367928005427 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 367928005428 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 367928005429 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 367928005430 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 367928005431 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 367928005432 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 367928005433 Catalytic domain of Protein Kinases; Region: PKc; cd00180 367928005434 active site 367928005435 ATP binding site [chemical binding]; other site 367928005436 substrate binding site [chemical binding]; other site 367928005437 activation loop (A-loop); other site 367928005438 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 367928005439 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 367928005440 catalytic residues [active] 367928005441 Domain of unknown function (DUF348); Region: DUF348; pfam03990 367928005442 Domain of unknown function (DUF348); Region: DUF348; pfam03990 367928005443 Domain of unknown function (DUF348); Region: DUF348; pfam03990 367928005444 G5 domain; Region: G5; pfam07501 367928005445 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 367928005446 N-acetyl-D-glucosamine binding site [chemical binding]; other site 367928005447 catalytic residue [active] 367928005448 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 367928005449 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 367928005450 S-adenosylmethionine binding site [chemical binding]; other site 367928005451 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 367928005452 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 367928005453 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 367928005454 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 367928005455 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 367928005456 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 367928005457 active site 367928005458 NTP binding site [chemical binding]; other site 367928005459 metal binding triad [ion binding]; metal-binding site 367928005460 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 367928005461 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 367928005462 Zn2+ binding site [ion binding]; other site 367928005463 Mg2+ binding site [ion binding]; other site 367928005464 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 367928005465 active site 367928005466 Ap6A binding site [chemical binding]; other site 367928005467 nudix motif; other site 367928005468 metal binding site [ion binding]; metal-binding site 367928005469 integral membrane protein MviN; Region: mviN; TIGR01695 367928005470 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 367928005471 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 367928005472 ATP binding site [chemical binding]; other site 367928005473 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 367928005474 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 367928005475 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 367928005476 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 367928005477 ParB-like nuclease domain; Region: ParB; smart00470 367928005478 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 367928005479 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 367928005480 P-loop; other site 367928005481 Magnesium ion binding site [ion binding]; other site 367928005482 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 367928005483 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 367928005484 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 367928005485 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 367928005486 G-X-X-G motif; other site 367928005487 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 367928005488 RxxxH motif; other site 367928005489 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 367928005490 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 367928005491 hypothetical protein; Provisional; Region: PRK14372 367928005492 Ribonuclease P; Region: Ribonuclease_P; pfam00825 367928005493 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399