-- dump date 20140619_001841 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1168290000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1168290000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290000003 Walker A motif; other site 1168290000004 ATP binding site [chemical binding]; other site 1168290000005 Walker B motif; other site 1168290000006 arginine finger; other site 1168290000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1168290000008 DnaA box-binding interface [nucleotide binding]; other site 1168290000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1168290000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1168290000011 putative DNA binding surface [nucleotide binding]; other site 1168290000012 dimer interface [polypeptide binding]; other site 1168290000013 beta-clamp/clamp loader binding surface; other site 1168290000014 beta-clamp/translesion DNA polymerase binding surface; other site 1168290000015 recombination protein F; Reviewed; Region: recF; PRK00064 1168290000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000017 Walker A/P-loop; other site 1168290000018 ATP binding site [chemical binding]; other site 1168290000019 Q-loop/lid; other site 1168290000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000021 ABC transporter signature motif; other site 1168290000022 Walker B; other site 1168290000023 D-loop; other site 1168290000024 H-loop/switch region; other site 1168290000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1168290000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1168290000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168290000028 Mg2+ binding site [ion binding]; other site 1168290000029 G-X-G motif; other site 1168290000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1168290000031 anchoring element; other site 1168290000032 dimer interface [polypeptide binding]; other site 1168290000033 ATP binding site [chemical binding]; other site 1168290000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1168290000035 active site 1168290000036 putative metal-binding site [ion binding]; other site 1168290000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1168290000038 DNA gyrase subunit A; Validated; Region: PRK05560 1168290000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1168290000040 CAP-like domain; other site 1168290000041 active site 1168290000042 primary dimer interface [polypeptide binding]; other site 1168290000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168290000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168290000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168290000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168290000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168290000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1168290000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1168290000050 VanZ like family; Region: VanZ; cl01971 1168290000051 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1168290000052 Haemolysin-III related; Region: HlyIII; pfam03006 1168290000053 glutamate dehydrogenase; Provisional; Region: PRK09414 1168290000054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1168290000055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1168290000056 NAD(P) binding site [chemical binding]; other site 1168290000057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290000059 putative substrate translocation pore; other site 1168290000060 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 1168290000061 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1168290000062 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1168290000063 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1168290000064 Protein of unknown function DUF45; Region: DUF45; pfam01863 1168290000065 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1168290000066 MarR family; Region: MarR_2; pfam12802 1168290000067 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1168290000068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1168290000069 non-specific DNA interactions [nucleotide binding]; other site 1168290000070 DNA binding site [nucleotide binding] 1168290000071 sequence specific DNA binding site [nucleotide binding]; other site 1168290000072 putative cAMP binding site [chemical binding]; other site 1168290000073 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000074 Walker A/P-loop; other site 1168290000075 ATP binding site [chemical binding]; other site 1168290000076 Q-loop/lid; other site 1168290000077 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1168290000078 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000079 ABC transporter signature motif; other site 1168290000080 Walker B; other site 1168290000081 D-loop; other site 1168290000082 H-loop/switch region; other site 1168290000083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000084 Walker A/P-loop; other site 1168290000085 ATP binding site [chemical binding]; other site 1168290000086 Q-loop/lid; other site 1168290000087 ABC transporter signature motif; other site 1168290000088 Walker B; other site 1168290000089 D-loop; other site 1168290000090 H-loop/switch region; other site 1168290000091 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168290000092 S-adenosylmethionine binding site [chemical binding]; other site 1168290000093 Predicted flavoprotein [General function prediction only]; Region: COG0431 1168290000094 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1168290000095 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1168290000096 homodimer interface [polypeptide binding]; other site 1168290000097 chemical substrate binding site [chemical binding]; other site 1168290000098 oligomer interface [polypeptide binding]; other site 1168290000099 metal binding site [ion binding]; metal-binding site 1168290000100 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1168290000101 GIY-YIG motif/motif A; other site 1168290000102 active site 1168290000103 catalytic site [active] 1168290000104 Helix-turn-helix domain; Region: HTH_17; pfam12728 1168290000105 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1168290000106 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1168290000107 cofactor binding site; other site 1168290000108 DNA binding site [nucleotide binding] 1168290000109 substrate interaction site [chemical binding]; other site 1168290000110 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1168290000111 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1168290000112 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1168290000113 PemK-like protein; Region: PemK; cl00995 1168290000114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168290000115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168290000116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1168290000117 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 1168290000118 catalytic tetrad [active] 1168290000119 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168290000120 active site 1168290000121 catalytic tetrad [active] 1168290000122 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168290000123 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1168290000124 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1168290000125 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1168290000126 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1168290000127 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1168290000128 Phosphotransferase enzyme family; Region: APH; pfam01636 1168290000129 substrate binding site [chemical binding]; other site 1168290000130 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1168290000131 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1168290000132 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1168290000133 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1168290000134 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1168290000135 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1168290000136 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1168290000137 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1168290000138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290000139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290000140 putative substrate translocation pore; other site 1168290000141 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168290000142 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168290000143 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1168290000144 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1168290000145 dimerization interface [polypeptide binding]; other site 1168290000146 DPS ferroxidase diiron center [ion binding]; other site 1168290000147 ion pore; other site 1168290000148 Domain of unknown function DUF21; Region: DUF21; pfam01595 1168290000149 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1168290000150 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1168290000151 Transporter associated domain; Region: CorC_HlyC; smart01091 1168290000152 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1168290000153 active site clefts [active] 1168290000154 zinc binding site [ion binding]; other site 1168290000155 dimer interface [polypeptide binding]; other site 1168290000156 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290000157 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290000158 DNA binding site [nucleotide binding] 1168290000159 domain linker motif; other site 1168290000160 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1168290000161 ligand binding site [chemical binding]; other site 1168290000162 dimerization interface (open form) [polypeptide binding]; other site 1168290000163 dimerization interface (closed form) [polypeptide binding]; other site 1168290000164 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1168290000165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000166 ABC transporter; Region: ABC_tran; pfam00005 1168290000167 Q-loop/lid; other site 1168290000168 ABC transporter signature motif; other site 1168290000169 Walker B; other site 1168290000170 D-loop; other site 1168290000171 H-loop/switch region; other site 1168290000172 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290000173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290000174 DNA binding site [nucleotide binding] 1168290000175 domain linker motif; other site 1168290000176 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1168290000177 ligand binding site [chemical binding]; other site 1168290000178 dimerization interface [polypeptide binding]; other site 1168290000179 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1168290000180 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1168290000181 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1168290000182 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1168290000183 putative N- and C-terminal domain interface [polypeptide binding]; other site 1168290000184 putative active site [active] 1168290000185 MgATP binding site [chemical binding]; other site 1168290000186 catalytic site [active] 1168290000187 metal binding site [ion binding]; metal-binding site 1168290000188 putative carbohydrate binding site [chemical binding]; other site 1168290000189 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1168290000190 intersubunit interface [polypeptide binding]; other site 1168290000191 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1168290000192 active site 1168290000193 Zn2+ binding site [ion binding]; other site 1168290000194 L-arabinose isomerase; Provisional; Region: PRK02929 1168290000195 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1168290000196 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1168290000197 trimer interface [polypeptide binding]; other site 1168290000198 substrate binding site [chemical binding]; other site 1168290000199 Mn binding site [ion binding]; other site 1168290000200 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168290000201 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168290000202 active site 1168290000203 catalytic tetrad [active] 1168290000204 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1168290000205 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1168290000206 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1168290000207 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1168290000208 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1168290000209 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1168290000210 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1168290000211 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1168290000212 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1168290000213 active site 1168290000214 HIGH motif; other site 1168290000215 dimer interface [polypeptide binding]; other site 1168290000216 KMSKS motif; other site 1168290000217 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1168290000218 homodimer interface [polypeptide binding]; other site 1168290000219 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1168290000220 active site pocket [active] 1168290000221 Rhomboid family; Region: Rhomboid; pfam01694 1168290000222 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1168290000223 putative septation inhibitor protein; Reviewed; Region: PRK02251 1168290000224 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1168290000225 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1168290000226 active site 1168290000227 catalytic site [active] 1168290000228 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1168290000229 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1168290000230 glutamine binding [chemical binding]; other site 1168290000231 catalytic triad [active] 1168290000232 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1168290000233 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168290000234 active site 1168290000235 ATP binding site [chemical binding]; other site 1168290000236 substrate binding site [chemical binding]; other site 1168290000237 activation loop (A-loop); other site 1168290000238 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168290000239 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168290000240 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168290000241 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168290000242 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168290000243 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168290000244 active site 1168290000245 ATP binding site [chemical binding]; other site 1168290000246 substrate binding site [chemical binding]; other site 1168290000247 activation loop (A-loop); other site 1168290000248 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1168290000249 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1168290000250 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1168290000251 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1168290000252 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1168290000253 active site 1168290000254 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168290000255 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168290000256 phosphopeptide binding site; other site 1168290000257 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1168290000258 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168290000259 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168290000260 phosphopeptide binding site; other site 1168290000261 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1168290000262 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168290000263 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1168290000264 EamA-like transporter family; Region: EamA; pfam00892 1168290000265 EamA-like transporter family; Region: EamA; pfam00892 1168290000266 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168290000267 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1168290000268 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1168290000269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168290000270 S-adenosylmethionine binding site [chemical binding]; other site 1168290000271 Predicted membrane protein [Function unknown]; Region: COG2261 1168290000272 ferredoxin-NADP+ reductase; Region: PLN02852 1168290000273 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168290000274 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1168290000275 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168290000276 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1168290000277 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1168290000278 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1168290000279 protein binding site [polypeptide binding]; other site 1168290000280 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1168290000281 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1168290000282 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1168290000283 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1168290000284 heat shock protein HtpX; Provisional; Region: PRK03072 1168290000285 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1168290000286 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1168290000287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290000288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290000289 putative substrate translocation pore; other site 1168290000290 RelB antitoxin; Region: RelB; cl01171 1168290000291 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1168290000292 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1168290000293 DNA binding site [nucleotide binding] 1168290000294 active site 1168290000295 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1168290000296 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1168290000297 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1168290000298 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1168290000299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168290000300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168290000301 active site 1168290000302 catalytic tetrad [active] 1168290000303 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1168290000304 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1168290000305 FAD binding pocket [chemical binding]; other site 1168290000306 conserved FAD binding motif [chemical binding]; other site 1168290000307 phosphate binding motif [ion binding]; other site 1168290000308 beta-alpha-beta structure motif; other site 1168290000309 NAD binding pocket [chemical binding]; other site 1168290000310 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1168290000311 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1168290000312 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1168290000313 DNA binding residues [nucleotide binding] 1168290000314 putative dimer interface [polypeptide binding]; other site 1168290000315 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1168290000316 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1168290000317 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1168290000318 NAD(P) binding site [chemical binding]; other site 1168290000319 putative active site [active] 1168290000320 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1168290000321 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1168290000322 catalytic Zn binding site [ion binding]; other site 1168290000323 NAD(P) binding site [chemical binding]; other site 1168290000324 structural Zn binding site [ion binding]; other site 1168290000325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168290000326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168290000327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1168290000328 dimerization interface [polypeptide binding]; other site 1168290000329 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1168290000330 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1168290000331 NodB motif; other site 1168290000332 active site 1168290000333 catalytic site [active] 1168290000334 metal binding site [ion binding]; metal-binding site 1168290000335 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1168290000336 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1168290000337 active site 1168290000338 intersubunit interface [polypeptide binding]; other site 1168290000339 zinc binding site [ion binding]; other site 1168290000340 Na+ binding site [ion binding]; other site 1168290000341 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1168290000342 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1168290000343 GDP-binding site [chemical binding]; other site 1168290000344 ACT binding site; other site 1168290000345 IMP binding site; other site 1168290000346 CrcB-like protein; Region: CRCB; pfam02537 1168290000347 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1168290000348 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1168290000349 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1168290000350 TM-ABC transporter signature motif; other site 1168290000351 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1168290000352 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1168290000353 TM-ABC transporter signature motif; other site 1168290000354 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1168290000355 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1168290000356 Walker A/P-loop; other site 1168290000357 ATP binding site [chemical binding]; other site 1168290000358 Q-loop/lid; other site 1168290000359 ABC transporter signature motif; other site 1168290000360 Walker B; other site 1168290000361 D-loop; other site 1168290000362 H-loop/switch region; other site 1168290000363 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1168290000364 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1168290000365 Walker A/P-loop; other site 1168290000366 ATP binding site [chemical binding]; other site 1168290000367 Q-loop/lid; other site 1168290000368 ABC transporter signature motif; other site 1168290000369 Walker B; other site 1168290000370 D-loop; other site 1168290000371 H-loop/switch region; other site 1168290000372 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1168290000373 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1168290000374 ligand binding site [chemical binding]; other site 1168290000375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290000376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290000377 DNA binding site [nucleotide binding] 1168290000378 domain linker motif; other site 1168290000379 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1168290000380 sucrose phosphorylase; Provisional; Region: PRK13840 1168290000381 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1168290000382 active site 1168290000383 homodimer interface [polypeptide binding]; other site 1168290000384 catalytic site [active] 1168290000385 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 1168290000386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290000387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290000388 putative substrate translocation pore; other site 1168290000389 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1168290000390 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1168290000391 ligand binding site [chemical binding]; other site 1168290000392 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1168290000393 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168290000394 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168290000395 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1168290000396 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 1168290000397 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1168290000398 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168290000399 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 1168290000400 metabolite-proton symporter; Region: 2A0106; TIGR00883 1168290000401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290000402 putative substrate translocation pore; other site 1168290000403 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1168290000404 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1168290000405 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1168290000406 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1168290000407 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1168290000408 active site 1168290000409 catalytic triad [active] 1168290000410 oxyanion hole [active] 1168290000411 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1168290000412 beta-galactosidase; Region: BGL; TIGR03356 1168290000413 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290000414 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290000415 DNA binding site [nucleotide binding] 1168290000416 domain linker motif; other site 1168290000417 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1168290000418 ligand binding site [chemical binding]; other site 1168290000419 dimerization interface [polypeptide binding]; other site 1168290000420 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1168290000421 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1168290000422 putative active cleft [active] 1168290000423 dimerization interface [polypeptide binding]; other site 1168290000424 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1168290000425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000426 Walker A/P-loop; other site 1168290000427 ATP binding site [chemical binding]; other site 1168290000428 Q-loop/lid; other site 1168290000429 ABC transporter signature motif; other site 1168290000430 Walker B; other site 1168290000431 D-loop; other site 1168290000432 H-loop/switch region; other site 1168290000433 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1168290000434 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1168290000435 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168290000436 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1168290000437 Walker A/P-loop; other site 1168290000438 ATP binding site [chemical binding]; other site 1168290000439 Q-loop/lid; other site 1168290000440 ABC transporter signature motif; other site 1168290000441 Walker B; other site 1168290000442 D-loop; other site 1168290000443 H-loop/switch region; other site 1168290000444 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1168290000445 FtsX-like permease family; Region: FtsX; pfam02687 1168290000446 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1168290000447 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1168290000448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000449 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168290000450 ABC transporter signature motif; other site 1168290000451 Walker B; other site 1168290000452 D-loop; other site 1168290000453 H-loop/switch region; other site 1168290000454 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1168290000455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168290000456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168290000457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000458 Walker A/P-loop; other site 1168290000459 ATP binding site [chemical binding]; other site 1168290000460 Q-loop/lid; other site 1168290000461 ABC transporter signature motif; other site 1168290000462 Walker B; other site 1168290000463 D-loop; other site 1168290000464 H-loop/switch region; other site 1168290000465 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168290000466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168290000467 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1168290000468 Walker A/P-loop; other site 1168290000469 ATP binding site [chemical binding]; other site 1168290000470 Q-loop/lid; other site 1168290000471 ABC transporter signature motif; other site 1168290000472 Walker B; other site 1168290000473 D-loop; other site 1168290000474 H-loop/switch region; other site 1168290000475 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1168290000476 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1168290000477 NodB motif; other site 1168290000478 active site 1168290000479 catalytic site [active] 1168290000480 metal binding site [ion binding]; metal-binding site 1168290000481 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1168290000482 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1168290000483 active site 1168290000484 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1168290000485 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1168290000486 active site 1168290000487 substrate binding site [chemical binding]; other site 1168290000488 trimer interface [polypeptide binding]; other site 1168290000489 CoA binding site [chemical binding]; other site 1168290000490 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1168290000491 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1168290000492 ligand binding site [chemical binding]; other site 1168290000493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168290000494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168290000495 Predicted membrane protein [Function unknown]; Region: COG1511 1168290000496 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1168290000497 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1168290000498 Predicted membrane protein [Function unknown]; Region: COG1511 1168290000499 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1168290000500 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1168290000501 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 1168290000502 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1168290000503 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168290000504 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168290000505 Walker A/P-loop; other site 1168290000506 ATP binding site [chemical binding]; other site 1168290000507 Q-loop/lid; other site 1168290000508 ABC transporter signature motif; other site 1168290000509 Walker B; other site 1168290000510 D-loop; other site 1168290000511 H-loop/switch region; other site 1168290000512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290000513 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1168290000514 Walker A/P-loop; other site 1168290000515 ATP binding site [chemical binding]; other site 1168290000516 Q-loop/lid; other site 1168290000517 ABC transporter signature motif; other site 1168290000518 Walker B; other site 1168290000519 D-loop; other site 1168290000520 H-loop/switch region; other site 1168290000521 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168290000522 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1168290000523 intersubunit interface [polypeptide binding]; other site 1168290000524 YodA lipocalin-like domain; Region: YodA; cl01365 1168290000525 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1168290000526 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1168290000527 active site 1168290000528 nucleophile elbow; other site 1168290000529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168290000530 Peptidase family C69; Region: Peptidase_C69; pfam03577 1168290000531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168290000532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168290000533 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1168290000534 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1168290000535 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168290000536 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1168290000537 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1168290000538 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1168290000539 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168290000540 metal binding triad; other site 1168290000541 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1168290000542 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1168290000543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168290000544 sequence-specific DNA binding site [nucleotide binding]; other site 1168290000545 salt bridge; other site 1168290000546 replicative DNA helicase; Region: DnaB; TIGR00665 1168290000547 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1168290000548 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1168290000549 Walker A motif; other site 1168290000550 ATP binding site [chemical binding]; other site 1168290000551 Walker B motif; other site 1168290000552 DNA binding loops [nucleotide binding] 1168290000553 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168290000554 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1168290000555 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1168290000556 catalytic triad [active] 1168290000557 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1168290000558 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1168290000559 ABC1 family; Region: ABC1; cl17513 1168290000560 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1168290000561 active site 1168290000562 catalytic site [active] 1168290000563 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1168290000564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168290000565 active site 1168290000566 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1168290000567 active site 1168290000568 Ap6A binding site [chemical binding]; other site 1168290000569 nudix motif; other site 1168290000570 metal binding site [ion binding]; metal-binding site 1168290000571 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290000572 catalytic core [active] 1168290000573 polyphosphate kinase; Provisional; Region: PRK05443 1168290000574 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1168290000575 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1168290000576 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1168290000577 putative domain interface [polypeptide binding]; other site 1168290000578 putative active site [active] 1168290000579 catalytic site [active] 1168290000580 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1168290000581 putative domain interface [polypeptide binding]; other site 1168290000582 putative active site [active] 1168290000583 catalytic site [active] 1168290000584 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1168290000585 Type II/IV secretion system protein; Region: T2SE; pfam00437 1168290000586 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1168290000587 Walker B motif; other site 1168290000588 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1168290000589 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1168290000590 TadE-like protein; Region: TadE; pfam07811 1168290000591 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1168290000592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290000593 Walker A motif; other site 1168290000594 ATP binding site [chemical binding]; other site 1168290000595 Walker B motif; other site 1168290000596 arginine finger; other site 1168290000597 recombination protein RecR; Reviewed; Region: recR; PRK00076 1168290000598 RecR protein; Region: RecR; pfam02132 1168290000599 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1168290000600 putative active site [active] 1168290000601 putative metal-binding site [ion binding]; other site 1168290000602 tetramer interface [polypeptide binding]; other site 1168290000603 aspartate kinase; Reviewed; Region: PRK06635 1168290000604 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1168290000605 putative nucleotide binding site [chemical binding]; other site 1168290000606 putative catalytic residues [active] 1168290000607 putative Mg ion binding site [ion binding]; other site 1168290000608 putative aspartate binding site [chemical binding]; other site 1168290000609 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1168290000610 putative allosteric regulatory site; other site 1168290000611 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1168290000612 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1168290000613 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1168290000614 2-isopropylmalate synthase; Validated; Region: PRK03739 1168290000615 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1168290000616 active site 1168290000617 catalytic residues [active] 1168290000618 metal binding site [ion binding]; metal-binding site 1168290000619 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1168290000620 Transglycosylase; Region: Transgly; pfam00912 1168290000621 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1168290000622 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1168290000623 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1168290000624 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1168290000625 PAP2 superfamily; Region: PAP2; pfam01569 1168290000626 active site 1168290000627 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1168290000628 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1168290000629 active site 1168290000630 interdomain interaction site; other site 1168290000631 putative metal-binding site [ion binding]; other site 1168290000632 nucleotide binding site [chemical binding]; other site 1168290000633 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1168290000634 domain I; other site 1168290000635 phosphate binding site [ion binding]; other site 1168290000636 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1168290000637 domain II; other site 1168290000638 domain III; other site 1168290000639 nucleotide binding site [chemical binding]; other site 1168290000640 DNA binding groove [nucleotide binding] 1168290000641 catalytic site [active] 1168290000642 domain IV; other site 1168290000643 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1168290000644 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1168290000645 thymidylate kinase; Validated; Region: tmk; PRK00698 1168290000646 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1168290000647 TMP-binding site; other site 1168290000648 ATP-binding site [chemical binding]; other site 1168290000649 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1168290000650 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1168290000651 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1168290000652 substrate binding site [chemical binding]; other site 1168290000653 Peptidase family C69; Region: Peptidase_C69; pfam03577 1168290000654 Peptidase family C69; Region: Peptidase_C69; pfam03577 1168290000655 AAA domain; Region: AAA_14; pfam13173 1168290000656 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1168290000657 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168290000658 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 1168290000659 Predicted membrane protein [Function unknown]; Region: COG2246 1168290000660 GtrA-like protein; Region: GtrA; pfam04138 1168290000661 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290000662 catalytic core [active] 1168290000663 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290000664 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290000665 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1168290000666 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1168290000667 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1168290000668 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1168290000669 active site 1168290000670 HIGH motif; other site 1168290000671 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1168290000672 active site 1168290000673 KMSKS motif; other site 1168290000674 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1168290000675 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1168290000676 putative active site [active] 1168290000677 putative metal binding site [ion binding]; other site 1168290000678 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1168290000679 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1168290000680 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1168290000681 Bacterial transcriptional regulator; Region: IclR; pfam01614 1168290000682 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1168290000683 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1168290000684 substrate binding site [chemical binding]; other site 1168290000685 ligand binding site [chemical binding]; other site 1168290000686 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1168290000687 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1168290000688 substrate binding site [chemical binding]; other site 1168290000689 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1168290000690 AsnC family; Region: AsnC_trans_reg; pfam01037 1168290000691 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1168290000692 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168290000693 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168290000694 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1168290000695 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1168290000696 hinge; other site 1168290000697 active site 1168290000698 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168290000699 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168290000700 putative acyl-acceptor binding pocket; other site 1168290000701 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1168290000702 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1168290000703 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1168290000704 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1168290000705 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1168290000706 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168290000707 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1168290000708 CAAX protease self-immunity; Region: Abi; pfam02517 1168290000709 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1168290000710 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1168290000711 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168290000712 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168290000713 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1168290000714 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1168290000715 nucleophilic elbow; other site 1168290000716 catalytic triad; other site 1168290000717 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1168290000718 Predicted membrane protein [Function unknown]; Region: COG4905 1168290000719 aspartate aminotransferase; Provisional; Region: PRK06836 1168290000720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290000721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290000722 homodimer interface [polypeptide binding]; other site 1168290000723 catalytic residue [active] 1168290000724 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1168290000725 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1168290000726 binding surface 1168290000727 TPR motif; other site 1168290000728 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1168290000729 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1168290000730 substrate binding site [chemical binding]; other site 1168290000731 ATP binding site [chemical binding]; other site 1168290000732 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1168290000733 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1168290000734 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1168290000735 ssDNA binding site; other site 1168290000736 generic binding surface II; other site 1168290000737 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168290000738 ATP binding site [chemical binding]; other site 1168290000739 putative Mg++ binding site [ion binding]; other site 1168290000740 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290000741 nucleotide binding region [chemical binding]; other site 1168290000742 ATP-binding site [chemical binding]; other site 1168290000743 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1168290000744 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168290000745 S-adenosylmethionine binding site [chemical binding]; other site 1168290000746 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1168290000747 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1168290000748 RimM N-terminal domain; Region: RimM; pfam01782 1168290000749 PRC-barrel domain; Region: PRC; pfam05239 1168290000750 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1168290000751 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1168290000752 G-X-X-G motif; other site 1168290000753 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1168290000754 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1168290000755 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1168290000756 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1168290000757 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1168290000758 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1168290000759 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1168290000760 putative catalytic site [active] 1168290000761 putative metal binding site [ion binding]; other site 1168290000762 putative phosphate binding site [ion binding]; other site 1168290000763 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1168290000764 putative catalytic site [active] 1168290000765 putative phosphate binding site [ion binding]; other site 1168290000766 putative metal binding site [ion binding]; other site 1168290000767 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1168290000768 Cation efflux family; Region: Cation_efflux; pfam01545 1168290000769 signal recognition particle protein; Provisional; Region: PRK10867 1168290000770 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1168290000771 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1168290000772 P loop; other site 1168290000773 GTP binding site [chemical binding]; other site 1168290000774 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1168290000775 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1168290000776 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168290000777 active site 1168290000778 HIGH motif; other site 1168290000779 nucleotide binding site [chemical binding]; other site 1168290000780 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1168290000781 KMSKS motif; other site 1168290000782 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1168290000783 tRNA binding surface [nucleotide binding]; other site 1168290000784 anticodon binding site; other site 1168290000785 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168290000786 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168290000787 ABC transporter; Region: ABC_tran_2; pfam12848 1168290000788 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168290000789 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168290000790 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1168290000791 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1168290000792 catalytic triad [active] 1168290000793 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1168290000794 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1168290000795 putative valine binding site [chemical binding]; other site 1168290000796 dimer interface [polypeptide binding]; other site 1168290000797 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1168290000798 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1168290000799 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168290000800 PYR/PP interface [polypeptide binding]; other site 1168290000801 dimer interface [polypeptide binding]; other site 1168290000802 TPP binding site [chemical binding]; other site 1168290000803 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168290000804 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1168290000805 TPP-binding site [chemical binding]; other site 1168290000806 dimer interface [polypeptide binding]; other site 1168290000807 ribonuclease III; Reviewed; Region: rnc; PRK00102 1168290000808 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1168290000809 dimerization interface [polypeptide binding]; other site 1168290000810 active site 1168290000811 metal binding site [ion binding]; metal-binding site 1168290000812 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1168290000813 dsRNA binding site [nucleotide binding]; other site 1168290000814 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1168290000815 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1168290000816 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1168290000817 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1168290000818 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1168290000819 active site 1168290000820 (T/H)XGH motif; other site 1168290000821 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1168290000822 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168290000823 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168290000824 active site 1168290000825 catalytic tetrad [active] 1168290000826 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1168290000827 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1168290000828 active site 1168290000829 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1168290000830 ribonuclease PH; Reviewed; Region: rph; PRK00173 1168290000831 hexamer interface [polypeptide binding]; other site 1168290000832 active site 1168290000833 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1168290000834 active site 1168290000835 dimerization interface [polypeptide binding]; other site 1168290000836 FemAB family; Region: FemAB; pfam02388 1168290000837 Membrane transport protein; Region: Mem_trans; cl09117 1168290000838 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1168290000839 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1168290000840 Substrate binding site; other site 1168290000841 Cupin domain; Region: Cupin_2; cl17218 1168290000842 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1168290000843 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1168290000844 active site 1168290000845 dimer interface [polypeptide binding]; other site 1168290000846 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1168290000847 dimer interface [polypeptide binding]; other site 1168290000848 active site 1168290000849 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1168290000850 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1168290000851 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1168290000852 Catalytic site [active] 1168290000853 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1168290000854 RNA/DNA hybrid binding site [nucleotide binding]; other site 1168290000855 active site 1168290000856 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1168290000857 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1168290000858 Walker A/P-loop; other site 1168290000859 ATP binding site [chemical binding]; other site 1168290000860 Q-loop/lid; other site 1168290000861 ABC transporter signature motif; other site 1168290000862 Walker B; other site 1168290000863 D-loop; other site 1168290000864 H-loop/switch region; other site 1168290000865 FtsX-like permease family; Region: FtsX; pfam02687 1168290000866 Predicted permeases [General function prediction only]; Region: COG0679 1168290000867 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1168290000868 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1168290000869 metal binding site [ion binding]; metal-binding site 1168290000870 putative dimer interface [polypeptide binding]; other site 1168290000871 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1168290000872 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1168290000873 homodimer interface [polypeptide binding]; other site 1168290000874 oligonucleotide binding site [chemical binding]; other site 1168290000875 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1168290000876 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1168290000877 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1168290000878 GTP1/OBG; Region: GTP1_OBG; pfam01018 1168290000879 Obg GTPase; Region: Obg; cd01898 1168290000880 G1 box; other site 1168290000881 GTP/Mg2+ binding site [chemical binding]; other site 1168290000882 Switch I region; other site 1168290000883 G2 box; other site 1168290000884 G3 box; other site 1168290000885 Switch II region; other site 1168290000886 G4 box; other site 1168290000887 G5 box; other site 1168290000888 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1168290000889 gamma-glutamyl kinase; Provisional; Region: PRK05429 1168290000890 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1168290000891 nucleotide binding site [chemical binding]; other site 1168290000892 homotetrameric interface [polypeptide binding]; other site 1168290000893 putative phosphate binding site [ion binding]; other site 1168290000894 putative allosteric binding site; other site 1168290000895 PUA domain; Region: PUA; pfam01472 1168290000896 aspartate aminotransferase; Provisional; Region: PRK05764 1168290000897 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290000898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290000899 homodimer interface [polypeptide binding]; other site 1168290000900 catalytic residue [active] 1168290000901 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1168290000902 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1168290000903 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1168290000904 putative homodimer interface [polypeptide binding]; other site 1168290000905 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1168290000906 heterodimer interface [polypeptide binding]; other site 1168290000907 homodimer interface [polypeptide binding]; other site 1168290000908 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1168290000909 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1168290000910 23S rRNA interface [nucleotide binding]; other site 1168290000911 L7/L12 interface [polypeptide binding]; other site 1168290000912 putative thiostrepton binding site; other site 1168290000913 L25 interface [polypeptide binding]; other site 1168290000914 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1168290000915 mRNA/rRNA interface [nucleotide binding]; other site 1168290000916 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1168290000917 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1168290000918 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1168290000919 BioY family; Region: BioY; pfam02632 1168290000920 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1168290000921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168290000922 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168290000923 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1168290000924 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1168290000925 carboxyltransferase (CT) interaction site; other site 1168290000926 biotinylation site [posttranslational modification]; other site 1168290000927 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1168290000928 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1168290000929 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1168290000930 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1168290000931 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1168290000932 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1168290000933 FMN binding site [chemical binding]; other site 1168290000934 substrate binding site [chemical binding]; other site 1168290000935 putative catalytic residue [active] 1168290000936 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1168290000937 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1168290000938 active site 2 [active] 1168290000939 active site 1 [active] 1168290000940 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1168290000941 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1168290000942 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1168290000943 putative NAD(P) binding site [chemical binding]; other site 1168290000944 active site 1168290000945 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1168290000946 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1168290000947 active site 1168290000948 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1168290000949 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1168290000950 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1168290000951 NAD binding site [chemical binding]; other site 1168290000952 dimer interface [polypeptide binding]; other site 1168290000953 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168290000954 substrate binding site [chemical binding]; other site 1168290000955 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1168290000956 16S/18S rRNA binding site [nucleotide binding]; other site 1168290000957 S13e-L30e interaction site [polypeptide binding]; other site 1168290000958 25S rRNA binding site [nucleotide binding]; other site 1168290000959 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1168290000960 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1168290000961 oligomer interface [polypeptide binding]; other site 1168290000962 RNA binding site [nucleotide binding]; other site 1168290000963 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1168290000964 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1168290000965 RNase E interface [polypeptide binding]; other site 1168290000966 trimer interface [polypeptide binding]; other site 1168290000967 active site 1168290000968 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1168290000969 putative nucleic acid binding region [nucleotide binding]; other site 1168290000970 G-X-X-G motif; other site 1168290000971 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1168290000972 RNA binding site [nucleotide binding]; other site 1168290000973 domain interface; other site 1168290000974 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1168290000975 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1168290000976 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1168290000977 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1168290000978 dimer interface [polypeptide binding]; other site 1168290000979 putative radical transfer pathway; other site 1168290000980 diiron center [ion binding]; other site 1168290000981 tyrosyl radical; other site 1168290000982 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1168290000983 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1168290000984 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1168290000985 active site 1168290000986 dimer interface [polypeptide binding]; other site 1168290000987 catalytic residues [active] 1168290000988 effector binding site; other site 1168290000989 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1168290000990 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1168290000991 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1168290000992 catalytic residues [active] 1168290000993 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168290000994 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168290000995 active site 1168290000996 catalytic tetrad [active] 1168290000997 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1168290000998 Peptidase family U32; Region: Peptidase_U32; pfam01136 1168290000999 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1168290001000 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1168290001001 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1168290001002 substrate binding site; other site 1168290001003 dimer interface; other site 1168290001004 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1168290001005 putative substrate binding pocket [chemical binding]; other site 1168290001006 AC domain interface; other site 1168290001007 catalytic triad [active] 1168290001008 AB domain interface; other site 1168290001009 interchain disulfide; other site 1168290001010 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1168290001011 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1168290001012 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1168290001013 trimer interface [polypeptide binding]; other site 1168290001014 active site 1168290001015 G bulge; other site 1168290001016 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1168290001017 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1168290001018 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1168290001019 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1168290001020 catalytic triad [active] 1168290001021 catalytic triad [active] 1168290001022 oxyanion hole [active] 1168290001023 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1168290001024 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1168290001025 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1168290001026 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1168290001027 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1168290001028 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168290001029 dimer interface [polypeptide binding]; other site 1168290001030 phosphorylation site [posttranslational modification] 1168290001031 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168290001032 ATP binding site [chemical binding]; other site 1168290001033 Mg2+ binding site [ion binding]; other site 1168290001034 G-X-G motif; other site 1168290001035 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168290001036 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168290001037 active site 1168290001038 phosphorylation site [posttranslational modification] 1168290001039 intermolecular recognition site; other site 1168290001040 dimerization interface [polypeptide binding]; other site 1168290001041 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168290001042 DNA binding site [nucleotide binding] 1168290001043 PBP superfamily domain; Region: PBP_like_2; cl17296 1168290001044 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1168290001045 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290001046 dimer interface [polypeptide binding]; other site 1168290001047 conserved gate region; other site 1168290001048 putative PBP binding loops; other site 1168290001049 ABC-ATPase subunit interface; other site 1168290001050 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1168290001051 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290001052 dimer interface [polypeptide binding]; other site 1168290001053 conserved gate region; other site 1168290001054 putative PBP binding loops; other site 1168290001055 ABC-ATPase subunit interface; other site 1168290001056 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1168290001057 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1168290001058 Walker A/P-loop; other site 1168290001059 ATP binding site [chemical binding]; other site 1168290001060 Q-loop/lid; other site 1168290001061 ABC transporter signature motif; other site 1168290001062 Walker B; other site 1168290001063 D-loop; other site 1168290001064 H-loop/switch region; other site 1168290001065 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1168290001066 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168290001067 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1168290001068 intersubunit interface [polypeptide binding]; other site 1168290001069 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1168290001070 23S rRNA interface [nucleotide binding]; other site 1168290001071 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1168290001072 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1168290001073 peripheral dimer interface [polypeptide binding]; other site 1168290001074 core dimer interface [polypeptide binding]; other site 1168290001075 L10 interface [polypeptide binding]; other site 1168290001076 L11 interface [polypeptide binding]; other site 1168290001077 putative EF-Tu interaction site [polypeptide binding]; other site 1168290001078 putative EF-G interaction site [polypeptide binding]; other site 1168290001079 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168290001080 phosphopeptide binding site; other site 1168290001081 Part of AAA domain; Region: AAA_19; pfam13245 1168290001082 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1168290001083 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1168290001084 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1168290001085 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1168290001086 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1168290001087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168290001088 Coenzyme A binding pocket [chemical binding]; other site 1168290001089 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1168290001090 oligomerisation interface [polypeptide binding]; other site 1168290001091 mobile loop; other site 1168290001092 roof hairpin; other site 1168290001093 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1168290001094 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1168290001095 FAD binding domain; Region: FAD_binding_4; pfam01565 1168290001096 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1168290001097 amino acid transporter; Region: 2A0306; TIGR00909 1168290001098 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1168290001099 Ferredoxin [Energy production and conversion]; Region: COG1146 1168290001100 4Fe-4S binding domain; Region: Fer4; pfam00037 1168290001101 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1168290001102 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290001103 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290001104 homodimer interface [polypeptide binding]; other site 1168290001105 catalytic residue [active] 1168290001106 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1168290001107 active site 1168290001108 DNA polymerase IV; Validated; Region: PRK02406 1168290001109 DNA binding site [nucleotide binding] 1168290001110 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1168290001111 dimerization interface [polypeptide binding]; other site 1168290001112 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1168290001113 NAD binding site [chemical binding]; other site 1168290001114 ligand binding site [chemical binding]; other site 1168290001115 catalytic site [active] 1168290001116 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1168290001117 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1168290001118 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1168290001119 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1168290001120 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1168290001121 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1168290001122 23S rRNA interface [nucleotide binding]; other site 1168290001123 L3 interface [polypeptide binding]; other site 1168290001124 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1168290001125 pullulanase, type I; Region: pulA_typeI; TIGR02104 1168290001126 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1168290001127 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1168290001128 active site 1168290001129 catalytic site [active] 1168290001130 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1168290001131 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168290001132 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168290001133 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1168290001134 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1168290001135 putative catalytic cysteine [active] 1168290001136 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1168290001137 putative active site [active] 1168290001138 metal binding site [ion binding]; metal-binding site 1168290001139 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1168290001140 YwiC-like protein; Region: YwiC; pfam14256 1168290001141 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1168290001142 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1168290001143 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1168290001144 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1168290001145 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1168290001146 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1168290001147 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1168290001148 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1168290001149 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1168290001150 protein-rRNA interface [nucleotide binding]; other site 1168290001151 putative translocon binding site; other site 1168290001152 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1168290001153 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1168290001154 G-X-X-G motif; other site 1168290001155 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1168290001156 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1168290001157 23S rRNA interface [nucleotide binding]; other site 1168290001158 5S rRNA interface [nucleotide binding]; other site 1168290001159 putative antibiotic binding site [chemical binding]; other site 1168290001160 L25 interface [polypeptide binding]; other site 1168290001161 L27 interface [polypeptide binding]; other site 1168290001162 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1168290001163 23S rRNA interface [nucleotide binding]; other site 1168290001164 putative translocon interaction site; other site 1168290001165 signal recognition particle (SRP54) interaction site; other site 1168290001166 L23 interface [polypeptide binding]; other site 1168290001167 trigger factor interaction site; other site 1168290001168 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1168290001169 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1168290001170 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1168290001171 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1168290001172 RNA binding site [nucleotide binding]; other site 1168290001173 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1168290001174 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1168290001175 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1168290001176 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1168290001177 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1168290001178 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1168290001179 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1168290001180 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1168290001181 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1168290001182 23S rRNA interface [nucleotide binding]; other site 1168290001183 L21e interface [polypeptide binding]; other site 1168290001184 5S rRNA interface [nucleotide binding]; other site 1168290001185 L27 interface [polypeptide binding]; other site 1168290001186 L5 interface [polypeptide binding]; other site 1168290001187 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1168290001188 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1168290001189 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1168290001190 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1168290001191 23S rRNA binding site [nucleotide binding]; other site 1168290001192 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1168290001193 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1168290001194 SecY translocase; Region: SecY; pfam00344 1168290001195 adenylate kinase; Reviewed; Region: adk; PRK00279 1168290001196 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1168290001197 AMP-binding site [chemical binding]; other site 1168290001198 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1168290001199 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1168290001200 rRNA binding site [nucleotide binding]; other site 1168290001201 predicted 30S ribosome binding site; other site 1168290001202 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1168290001203 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1168290001204 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1168290001205 30S ribosomal protein S11; Validated; Region: PRK05309 1168290001206 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1168290001207 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1168290001208 alphaNTD homodimer interface [polypeptide binding]; other site 1168290001209 alphaNTD - beta interaction site [polypeptide binding]; other site 1168290001210 alphaNTD - beta' interaction site [polypeptide binding]; other site 1168290001211 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1168290001212 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1168290001213 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1168290001214 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1168290001215 dimerization interface 3.5A [polypeptide binding]; other site 1168290001216 active site 1168290001217 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1168290001218 NusA N-terminal domain; Region: NusA_N; pfam08529 1168290001219 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1168290001220 RNA binding site [nucleotide binding]; other site 1168290001221 homodimer interface [polypeptide binding]; other site 1168290001222 NusA-like KH domain; Region: KH_5; pfam13184 1168290001223 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1168290001224 G-X-X-G motif; other site 1168290001225 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1168290001226 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1168290001227 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1168290001228 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1168290001229 G1 box; other site 1168290001230 putative GEF interaction site [polypeptide binding]; other site 1168290001231 GTP/Mg2+ binding site [chemical binding]; other site 1168290001232 Switch I region; other site 1168290001233 G2 box; other site 1168290001234 G3 box; other site 1168290001235 Switch II region; other site 1168290001236 G4 box; other site 1168290001237 G5 box; other site 1168290001238 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1168290001239 Translation-initiation factor 2; Region: IF-2; pfam11987 1168290001240 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1168290001241 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1168290001242 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1168290001243 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1168290001244 RNA binding site [nucleotide binding]; other site 1168290001245 active site 1168290001246 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1168290001247 FAD synthetase; Region: FAD_syn; pfam06574 1168290001248 active site 1168290001249 nucleotide binding site [chemical binding]; other site 1168290001250 HIGH motif; other site 1168290001251 KMSKS motif; other site 1168290001252 Riboflavin kinase; Region: Flavokinase; smart00904 1168290001253 DNA repair protein RadA; Provisional; Region: PRK11823 1168290001254 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1168290001255 Walker A motif; other site 1168290001256 ATP binding site [chemical binding]; other site 1168290001257 Walker B motif; other site 1168290001258 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1168290001259 ADP-ribosylation factor GTPase-activating protein AGD10; Provisional; Region: PLN03114 1168290001260 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1168290001261 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168290001262 active site 1168290001263 dimer interface [polypeptide binding]; other site 1168290001264 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1168290001265 RNA/DNA hybrid binding site [nucleotide binding]; other site 1168290001266 active site 1168290001267 seryl-tRNA synthetase; Provisional; Region: PRK05431 1168290001268 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1168290001269 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1168290001270 dimer interface [polypeptide binding]; other site 1168290001271 active site 1168290001272 motif 1; other site 1168290001273 motif 2; other site 1168290001274 motif 3; other site 1168290001275 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1168290001276 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1168290001277 phosphoglucomutase; Validated; Region: PRK07564 1168290001278 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1168290001279 active site 1168290001280 substrate binding site [chemical binding]; other site 1168290001281 metal binding site [ion binding]; metal-binding site 1168290001282 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1168290001283 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 1168290001284 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1168290001285 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1168290001286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1168290001287 binding surface 1168290001288 TPR motif; other site 1168290001289 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1168290001290 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168290001291 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168290001292 active site 1168290001293 phosphorylation site [posttranslational modification] 1168290001294 intermolecular recognition site; other site 1168290001295 dimerization interface [polypeptide binding]; other site 1168290001296 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168290001297 DNA binding residues [nucleotide binding] 1168290001298 dimerization interface [polypeptide binding]; other site 1168290001299 PspC domain; Region: PspC; pfam04024 1168290001300 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168290001301 PspC domain; Region: PspC; pfam04024 1168290001302 IncA protein; Region: IncA; pfam04156 1168290001303 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1168290001304 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1168290001305 homodimer interface [polypeptide binding]; other site 1168290001306 substrate-cofactor binding pocket; other site 1168290001307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290001308 catalytic residue [active] 1168290001309 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1168290001310 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168290001311 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168290001312 catalytic residue [active] 1168290001313 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1168290001314 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168290001315 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1168290001316 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1168290001317 dimer interface [polypeptide binding]; other site 1168290001318 putative anticodon binding site; other site 1168290001319 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168290001320 motif 1; other site 1168290001321 dimer interface [polypeptide binding]; other site 1168290001322 active site 1168290001323 motif 2; other site 1168290001324 motif 3; other site 1168290001325 Phospholipase B; Region: Phospholip_B; pfam04916 1168290001326 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1168290001327 trimer interface [polypeptide binding]; other site 1168290001328 active site 1168290001329 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1168290001330 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1168290001331 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1168290001332 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1168290001333 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1168290001334 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1168290001335 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1168290001336 UbiA prenyltransferase family; Region: UbiA; pfam01040 1168290001337 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290001338 catalytic core [active] 1168290001339 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290001340 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1168290001341 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1168290001342 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1168290001343 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1168290001344 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1168290001345 NAD(P) binding site [chemical binding]; other site 1168290001346 mannose-6-phosphate isomerase; Region: PLN02288 1168290001347 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1168290001348 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1168290001349 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1168290001350 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168290001351 ATP binding site [chemical binding]; other site 1168290001352 Mg2+ binding site [ion binding]; other site 1168290001353 G-X-G motif; other site 1168290001354 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1168290001355 PhoU domain; Region: PhoU; pfam01895 1168290001356 PhoU domain; Region: PhoU; pfam01895 1168290001357 phosphoserine aminotransferase; Provisional; Region: PRK03080 1168290001358 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168290001359 catalytic residue [active] 1168290001360 CHAP domain; Region: CHAP; pfam05257 1168290001361 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1168290001362 NlpC/P60 family; Region: NLPC_P60; cl17555 1168290001363 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168290001364 Ligand Binding Site [chemical binding]; other site 1168290001365 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168290001366 Ligand Binding Site [chemical binding]; other site 1168290001367 OsmC-like protein; Region: OsmC; cl00767 1168290001368 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1168290001369 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1168290001370 dimerization interface [polypeptide binding]; other site 1168290001371 active site 1168290001372 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1168290001373 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1168290001374 folate binding site [chemical binding]; other site 1168290001375 NADP+ binding site [chemical binding]; other site 1168290001376 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1168290001377 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1168290001378 active site 1168290001379 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1168290001380 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168290001381 NAD(P) binding site [chemical binding]; other site 1168290001382 active site 1168290001383 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1168290001384 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1168290001385 putative active site [active] 1168290001386 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1168290001387 serine/threonine protein kinase; Provisional; Region: PRK14879 1168290001388 AAA domain; Region: AAA_21; pfam13304 1168290001389 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1168290001390 putative active site [active] 1168290001391 putative metal-binding site [ion binding]; other site 1168290001392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1168290001393 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1168290001394 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1168290001395 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1168290001396 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1168290001397 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1168290001398 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1168290001399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1168290001400 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1168290001401 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1168290001402 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1168290001403 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1168290001404 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1168290001405 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1168290001406 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1168290001407 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1168290001408 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1168290001409 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1168290001410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290001411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290001412 DNA binding site [nucleotide binding] 1168290001413 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1168290001414 putative dimerization interface [polypeptide binding]; other site 1168290001415 putative ligand binding site [chemical binding]; other site 1168290001416 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1168290001417 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290001418 motif II; other site 1168290001419 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1168290001420 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1168290001421 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1168290001422 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1168290001423 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1168290001424 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1168290001425 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1168290001426 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1168290001427 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168290001428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290001429 dimer interface [polypeptide binding]; other site 1168290001430 conserved gate region; other site 1168290001431 putative PBP binding loops; other site 1168290001432 ABC-ATPase subunit interface; other site 1168290001433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290001434 dimer interface [polypeptide binding]; other site 1168290001435 conserved gate region; other site 1168290001436 putative PBP binding loops; other site 1168290001437 ABC-ATPase subunit interface; other site 1168290001438 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290001439 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290001440 DNA binding site [nucleotide binding] 1168290001441 domain linker motif; other site 1168290001442 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1168290001443 ligand binding site [chemical binding]; other site 1168290001444 dimerization interface (open form) [polypeptide binding]; other site 1168290001445 dimerization interface (closed form) [polypeptide binding]; other site 1168290001446 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1168290001447 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1168290001448 active site 1168290001449 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1168290001450 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1168290001451 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1168290001452 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1168290001453 DXD motif; other site 1168290001454 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1168290001455 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1168290001456 Walker A/P-loop; other site 1168290001457 ATP binding site [chemical binding]; other site 1168290001458 Q-loop/lid; other site 1168290001459 ABC transporter signature motif; other site 1168290001460 Walker B; other site 1168290001461 D-loop; other site 1168290001462 H-loop/switch region; other site 1168290001463 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1168290001464 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1168290001465 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1168290001466 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1168290001467 Ligand Binding Site [chemical binding]; other site 1168290001468 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168290001469 active site 1168290001470 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1168290001471 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290001472 Walker A motif; other site 1168290001473 ATP binding site [chemical binding]; other site 1168290001474 Walker B motif; other site 1168290001475 arginine finger; other site 1168290001476 Peptidase family M41; Region: Peptidase_M41; pfam01434 1168290001477 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1168290001478 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1168290001479 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1168290001480 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1168290001481 active site 1168290001482 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1168290001483 catalytic triad [active] 1168290001484 dimer interface [polypeptide binding]; other site 1168290001485 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1168290001486 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168290001487 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168290001488 ABC transporter; Region: ABC_tran_2; pfam12848 1168290001489 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168290001490 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1168290001491 active site 1168290001492 catalytic residues [active] 1168290001493 metal binding site [ion binding]; metal-binding site 1168290001494 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1168290001495 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1168290001496 homodimer interface [polypeptide binding]; other site 1168290001497 substrate-cofactor binding pocket; other site 1168290001498 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290001499 catalytic residue [active] 1168290001500 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1168290001501 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1168290001502 xylose isomerase; Provisional; Region: PRK05474 1168290001503 xylose isomerase; Region: xylose_isom_A; TIGR02630 1168290001504 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1168290001505 active site 1168290001506 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290001507 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290001508 DNA binding site [nucleotide binding] 1168290001509 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 1168290001510 putative ligand binding site [chemical binding]; other site 1168290001511 putative dimerization interface [polypeptide binding]; other site 1168290001512 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1168290001513 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1168290001514 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1168290001515 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290001516 dimer interface [polypeptide binding]; other site 1168290001517 conserved gate region; other site 1168290001518 putative PBP binding loops; other site 1168290001519 ABC-ATPase subunit interface; other site 1168290001520 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168290001521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290001522 dimer interface [polypeptide binding]; other site 1168290001523 conserved gate region; other site 1168290001524 putative PBP binding loops; other site 1168290001525 ABC-ATPase subunit interface; other site 1168290001526 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1168290001527 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1168290001528 inhibitor binding site; inhibition site 1168290001529 active site 1168290001530 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1168290001531 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1168290001532 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168290001533 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1168290001534 substrate binding pocket [chemical binding]; other site 1168290001535 catalytic triad [active] 1168290001536 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168290001537 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1168290001538 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1168290001539 active site 1168290001540 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168290001541 D-xylulose kinase; Region: XylB; TIGR01312 1168290001542 nucleotide binding site [chemical binding]; other site 1168290001543 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1168290001544 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168290001545 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168290001546 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1168290001547 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1168290001548 PCRF domain; Region: PCRF; pfam03462 1168290001549 RF-1 domain; Region: RF-1; pfam00472 1168290001550 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1168290001551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1168290001552 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1168290001553 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1168290001554 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1168290001555 Mg++ binding site [ion binding]; other site 1168290001556 putative catalytic motif [active] 1168290001557 substrate binding site [chemical binding]; other site 1168290001558 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1168290001559 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168290001560 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1168290001561 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1168290001562 active site 1168290001563 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1168290001564 catalytic site [active] 1168290001565 putative active site [active] 1168290001566 putative substrate binding site [chemical binding]; other site 1168290001567 dimer interface [polypeptide binding]; other site 1168290001568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290001569 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1168290001570 active site 1168290001571 motif I; other site 1168290001572 motif II; other site 1168290001573 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1168290001574 AAA domain; Region: AAA_30; pfam13604 1168290001575 PIF1-like helicase; Region: PIF1; pfam05970 1168290001576 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1168290001577 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1168290001578 dimer interface [polypeptide binding]; other site 1168290001579 motif 1; other site 1168290001580 active site 1168290001581 motif 2; other site 1168290001582 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1168290001583 putative deacylase active site [active] 1168290001584 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168290001585 active site 1168290001586 motif 3; other site 1168290001587 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1168290001588 anticodon binding site; other site 1168290001589 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1168290001590 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1168290001591 dimer interface [polypeptide binding]; other site 1168290001592 ssDNA binding site [nucleotide binding]; other site 1168290001593 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168290001594 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1168290001595 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1168290001596 active site 1168290001597 Zn binding site [ion binding]; other site 1168290001598 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1168290001599 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1168290001600 active site 1168290001601 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1168290001602 Citrate synthase; Region: Citrate_synt; pfam00285 1168290001603 oxalacetate binding site [chemical binding]; other site 1168290001604 citrylCoA binding site [chemical binding]; other site 1168290001605 coenzyme A binding site [chemical binding]; other site 1168290001606 catalytic triad [active] 1168290001607 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1168290001608 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1168290001609 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1168290001610 putative trimer interface [polypeptide binding]; other site 1168290001611 putative CoA binding site [chemical binding]; other site 1168290001612 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1168290001613 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1168290001614 RF-1 domain; Region: RF-1; pfam00472 1168290001615 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1168290001616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290001617 Walker A/P-loop; other site 1168290001618 ATP binding site [chemical binding]; other site 1168290001619 Q-loop/lid; other site 1168290001620 ABC transporter signature motif; other site 1168290001621 Walker B; other site 1168290001622 D-loop; other site 1168290001623 H-loop/switch region; other site 1168290001624 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1168290001625 FtsX-like permease family; Region: FtsX; pfam02687 1168290001626 Surface antigen [General function prediction only]; Region: COG3942 1168290001627 CHAP domain; Region: CHAP; pfam05257 1168290001628 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1168290001629 SmpB-tmRNA interface; other site 1168290001630 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168290001631 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1168290001632 substrate binding pocket [chemical binding]; other site 1168290001633 membrane-bound complex binding site; other site 1168290001634 hinge residues; other site 1168290001635 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168290001636 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1168290001637 substrate binding pocket [chemical binding]; other site 1168290001638 membrane-bound complex binding site; other site 1168290001639 hinge residues; other site 1168290001640 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1168290001641 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290001642 dimer interface [polypeptide binding]; other site 1168290001643 conserved gate region; other site 1168290001644 putative PBP binding loops; other site 1168290001645 ABC-ATPase subunit interface; other site 1168290001646 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1168290001647 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1168290001648 Walker A/P-loop; other site 1168290001649 ATP binding site [chemical binding]; other site 1168290001650 Q-loop/lid; other site 1168290001651 ABC transporter signature motif; other site 1168290001652 Walker B; other site 1168290001653 D-loop; other site 1168290001654 H-loop/switch region; other site 1168290001655 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168290001656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168290001657 active site 1168290001658 phosphorylation site [posttranslational modification] 1168290001659 intermolecular recognition site; other site 1168290001660 dimerization interface [polypeptide binding]; other site 1168290001661 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168290001662 DNA binding residues [nucleotide binding] 1168290001663 dimerization interface [polypeptide binding]; other site 1168290001664 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1168290001665 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1168290001666 glutaminase active site [active] 1168290001667 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1168290001668 dimer interface [polypeptide binding]; other site 1168290001669 active site 1168290001670 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1168290001671 dimer interface [polypeptide binding]; other site 1168290001672 active site 1168290001673 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1168290001674 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1168290001675 active site 1168290001676 pantothenate kinase; Reviewed; Region: PRK13318 1168290001677 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168290001678 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1168290001679 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168290001680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290001681 dimer interface [polypeptide binding]; other site 1168290001682 conserved gate region; other site 1168290001683 putative PBP binding loops; other site 1168290001684 ABC-ATPase subunit interface; other site 1168290001685 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1168290001686 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290001687 dimer interface [polypeptide binding]; other site 1168290001688 conserved gate region; other site 1168290001689 putative PBP binding loops; other site 1168290001690 ABC-ATPase subunit interface; other site 1168290001691 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1168290001692 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168290001693 Walker A/P-loop; other site 1168290001694 ATP binding site [chemical binding]; other site 1168290001695 Q-loop/lid; other site 1168290001696 ABC transporter signature motif; other site 1168290001697 Walker B; other site 1168290001698 D-loop; other site 1168290001699 H-loop/switch region; other site 1168290001700 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1168290001701 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168290001702 Walker A/P-loop; other site 1168290001703 ATP binding site [chemical binding]; other site 1168290001704 Q-loop/lid; other site 1168290001705 ABC transporter signature motif; other site 1168290001706 Walker B; other site 1168290001707 D-loop; other site 1168290001708 H-loop/switch region; other site 1168290001709 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168290001710 cystathionine gamma-synthase; Provisional; Region: PRK07811 1168290001711 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1168290001712 homodimer interface [polypeptide binding]; other site 1168290001713 substrate-cofactor binding pocket; other site 1168290001714 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290001715 catalytic residue [active] 1168290001716 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1168290001717 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1168290001718 dimer interface [polypeptide binding]; other site 1168290001719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290001720 catalytic residue [active] 1168290001721 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1168290001722 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1168290001723 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168290001724 ATP binding site [chemical binding]; other site 1168290001725 ATP binding site [chemical binding]; other site 1168290001726 putative Mg++ binding site [ion binding]; other site 1168290001727 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290001728 nucleotide binding region [chemical binding]; other site 1168290001729 ATP-binding site [chemical binding]; other site 1168290001730 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1168290001731 HRDC domain; Region: HRDC; pfam00570 1168290001732 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1168290001733 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168290001734 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1168290001735 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1168290001736 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1168290001737 active site 1168290001738 8-oxo-dGMP binding site [chemical binding]; other site 1168290001739 nudix motif; other site 1168290001740 metal binding site [ion binding]; metal-binding site 1168290001741 potential frameshift: common BLAST hit: gi|384195175|ref|YP_005580920.1| superfamily II DNA/RNA helicase 1168290001742 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1168290001743 PLD-like domain; Region: PLDc_2; pfam13091 1168290001744 putative homodimer interface [polypeptide binding]; other site 1168290001745 putative active site [active] 1168290001746 catalytic site [active] 1168290001747 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1168290001748 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168290001749 ATP binding site [chemical binding]; other site 1168290001750 putative Mg++ binding site [ion binding]; other site 1168290001751 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290001752 nucleotide binding region [chemical binding]; other site 1168290001753 ATP-binding site [chemical binding]; other site 1168290001754 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1168290001755 Fic family protein [Function unknown]; Region: COG3177 1168290001756 Protein of unknown function DUF262; Region: DUF262; pfam03235 1168290001757 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1168290001758 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1168290001759 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1168290001760 Fic/DOC family; Region: Fic; cl00960 1168290001761 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1168290001762 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168290001763 Coenzyme A binding pocket [chemical binding]; other site 1168290001764 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1168290001765 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1168290001766 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1168290001767 putative active site [active] 1168290001768 metal binding site [ion binding]; metal-binding site 1168290001769 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1168290001770 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1168290001771 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1168290001772 alanine racemase; Reviewed; Region: alr; PRK00053 1168290001773 active site 1168290001774 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168290001775 dimer interface [polypeptide binding]; other site 1168290001776 substrate binding site [chemical binding]; other site 1168290001777 catalytic residues [active] 1168290001778 DNA primase; Validated; Region: dnaG; PRK05667 1168290001779 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1168290001780 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1168290001781 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1168290001782 active site 1168290001783 metal binding site [ion binding]; metal-binding site 1168290001784 interdomain interaction site; other site 1168290001785 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1168290001786 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1168290001787 transmembrane helices; other site 1168290001788 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1168290001789 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1168290001790 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1168290001791 TPP-binding site; other site 1168290001792 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1168290001793 PYR/PP interface [polypeptide binding]; other site 1168290001794 dimer interface [polypeptide binding]; other site 1168290001795 TPP binding site [chemical binding]; other site 1168290001796 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1168290001797 AIR carboxylase; Region: AIRC; pfam00731 1168290001798 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1168290001799 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1168290001800 NAD binding site [chemical binding]; other site 1168290001801 ATP-grasp domain; Region: ATP-grasp; pfam02222 1168290001802 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1168290001803 metal binding site 2 [ion binding]; metal-binding site 1168290001804 putative DNA binding helix; other site 1168290001805 metal binding site 1 [ion binding]; metal-binding site 1168290001806 dimer interface [polypeptide binding]; other site 1168290001807 structural Zn2+ binding site [ion binding]; other site 1168290001808 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1168290001809 Putative esterase; Region: Esterase; pfam00756 1168290001810 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1168290001811 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1168290001812 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1168290001813 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1168290001814 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1168290001815 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1168290001816 dimerization interface [polypeptide binding]; other site 1168290001817 putative ATP binding site [chemical binding]; other site 1168290001818 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1168290001819 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1168290001820 active site 1168290001821 tetramer interface [polypeptide binding]; other site 1168290001822 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168290001823 active site 1168290001824 Y-family of DNA polymerases; Region: PolY; cl12025 1168290001825 DNA polymerase IV; Reviewed; Region: PRK03103 1168290001826 active site 1168290001827 DNA binding site [nucleotide binding] 1168290001828 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1168290001829 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1168290001830 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1168290001831 Short C-terminal domain; Region: SHOCT; pfam09851 1168290001832 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1168290001833 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1168290001834 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1168290001835 dimerization interface [polypeptide binding]; other site 1168290001836 ATP binding site [chemical binding]; other site 1168290001837 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1168290001838 dimerization interface [polypeptide binding]; other site 1168290001839 ATP binding site [chemical binding]; other site 1168290001840 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1168290001841 conserved cys residue [active] 1168290001842 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1168290001843 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1168290001844 ATP binding site [chemical binding]; other site 1168290001845 active site 1168290001846 substrate binding site [chemical binding]; other site 1168290001847 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1168290001848 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168290001849 ATP-grasp domain; Region: ATP-grasp; pfam02222 1168290001850 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1168290001851 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168290001852 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1168290001853 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1168290001854 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168290001855 catalytic residue [active] 1168290001856 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1168290001857 S17 interaction site [polypeptide binding]; other site 1168290001858 S8 interaction site; other site 1168290001859 16S rRNA interaction site [nucleotide binding]; other site 1168290001860 streptomycin interaction site [chemical binding]; other site 1168290001861 23S rRNA interaction site [nucleotide binding]; other site 1168290001862 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1168290001863 30S ribosomal protein S7; Validated; Region: PRK05302 1168290001864 elongation factor G; Reviewed; Region: PRK00007 1168290001865 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1168290001866 G1 box; other site 1168290001867 putative GEF interaction site [polypeptide binding]; other site 1168290001868 GTP/Mg2+ binding site [chemical binding]; other site 1168290001869 Switch I region; other site 1168290001870 G2 box; other site 1168290001871 G3 box; other site 1168290001872 Switch II region; other site 1168290001873 G4 box; other site 1168290001874 G5 box; other site 1168290001875 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1168290001876 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1168290001877 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1168290001878 elongation factor Tu; Reviewed; Region: PRK00049 1168290001879 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1168290001880 G1 box; other site 1168290001881 GEF interaction site [polypeptide binding]; other site 1168290001882 GTP/Mg2+ binding site [chemical binding]; other site 1168290001883 Switch I region; other site 1168290001884 G2 box; other site 1168290001885 G3 box; other site 1168290001886 Switch II region; other site 1168290001887 G4 box; other site 1168290001888 G5 box; other site 1168290001889 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1168290001890 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1168290001891 Antibiotic Binding Site [chemical binding]; other site 1168290001892 Plant phosphoribosyltransferase C-terminal; Region: PRT_C; pfam08372 1168290001893 elongation factor P; Validated; Region: PRK00529 1168290001894 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1168290001895 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1168290001896 RNA binding site [nucleotide binding]; other site 1168290001897 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1168290001898 RNA binding site [nucleotide binding]; other site 1168290001899 transcription antitermination factor NusB; Region: nusB; TIGR01951 1168290001900 putative RNA binding site [nucleotide binding]; other site 1168290001901 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1168290001902 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1168290001903 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1168290001904 catalytic site [active] 1168290001905 subunit interface [polypeptide binding]; other site 1168290001906 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1168290001907 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168290001908 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168290001909 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1168290001910 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1168290001911 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1168290001912 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1168290001913 IMP binding site; other site 1168290001914 dimer interface [polypeptide binding]; other site 1168290001915 interdomain contacts; other site 1168290001916 partial ornithine binding site; other site 1168290001917 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1168290001918 active site 1168290001919 dimer interface [polypeptide binding]; other site 1168290001920 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1168290001921 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1168290001922 catalytic site [active] 1168290001923 G-X2-G-X-G-K; other site 1168290001924 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1168290001925 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1168290001926 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1168290001927 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1168290001928 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1168290001929 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1168290001930 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1168290001931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168290001932 S-adenosylmethionine binding site [chemical binding]; other site 1168290001933 primosome assembly protein PriA; Provisional; Region: PRK14873 1168290001934 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1168290001935 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1168290001936 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1168290001937 putative active site [active] 1168290001938 substrate binding site [chemical binding]; other site 1168290001939 putative cosubstrate binding site; other site 1168290001940 catalytic site [active] 1168290001941 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1168290001942 substrate binding site [chemical binding]; other site 1168290001943 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1168290001944 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290001945 motif II; other site 1168290001946 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1168290001947 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1168290001948 proteasome ATPase; Region: pup_AAA; TIGR03689 1168290001949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290001950 Walker A motif; other site 1168290001951 ATP binding site [chemical binding]; other site 1168290001952 Walker B motif; other site 1168290001953 arginine finger; other site 1168290001954 Pup-ligase protein; Region: Pup_ligase; cl15463 1168290001955 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1168290001956 active site 1168290001957 Pup-like protein; Region: Pup; cl05289 1168290001958 Pup-ligase protein; Region: Pup_ligase; cl15463 1168290001959 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1168290001960 IHF dimer interface [polypeptide binding]; other site 1168290001961 IHF - DNA interface [nucleotide binding]; other site 1168290001962 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1168290001963 adenylosuccinate lyase; Provisional; Region: PRK09285 1168290001964 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1168290001965 tetramer interface [polypeptide binding]; other site 1168290001966 active site 1168290001967 Secretory lipase; Region: LIP; pfam03583 1168290001968 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1168290001969 metal ion-dependent adhesion site (MIDAS); other site 1168290001970 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1168290001971 metal ion-dependent adhesion site (MIDAS); other site 1168290001972 Protein of unknown function DUF58; Region: DUF58; pfam01882 1168290001973 MoxR-like ATPases [General function prediction only]; Region: COG0714 1168290001974 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1168290001975 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1168290001976 ligand binding site [chemical binding]; other site 1168290001977 active site 1168290001978 UGI interface [polypeptide binding]; other site 1168290001979 catalytic site [active] 1168290001980 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168290001981 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1168290001982 DNA-binding site [nucleotide binding]; DNA binding site 1168290001983 RNA-binding motif; other site 1168290001984 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1168290001985 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1168290001986 ring oligomerisation interface [polypeptide binding]; other site 1168290001987 ATP/Mg binding site [chemical binding]; other site 1168290001988 stacking interactions; other site 1168290001989 hinge regions; other site 1168290001990 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1168290001991 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168290001992 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168290001993 active site 1168290001994 phosphorylation site [posttranslational modification] 1168290001995 intermolecular recognition site; other site 1168290001996 dimerization interface [polypeptide binding]; other site 1168290001997 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168290001998 DNA binding site [nucleotide binding] 1168290001999 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168290002000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168290002001 dimerization interface [polypeptide binding]; other site 1168290002002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168290002003 dimer interface [polypeptide binding]; other site 1168290002004 phosphorylation site [posttranslational modification] 1168290002005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168290002006 ATP binding site [chemical binding]; other site 1168290002007 Mg2+ binding site [ion binding]; other site 1168290002008 G-X-G motif; other site 1168290002009 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1168290002010 DNA-binding site [nucleotide binding]; DNA binding site 1168290002011 RNA-binding motif; other site 1168290002012 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1168290002013 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168290002014 Ligand Binding Site [chemical binding]; other site 1168290002015 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1168290002016 Ligand Binding Site [chemical binding]; other site 1168290002017 Clp protease ATP binding subunit; Region: clpC; CHL00095 1168290002018 Clp amino terminal domain; Region: Clp_N; pfam02861 1168290002019 Clp amino terminal domain; Region: Clp_N; pfam02861 1168290002020 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290002021 Walker A motif; other site 1168290002022 ATP binding site [chemical binding]; other site 1168290002023 Walker B motif; other site 1168290002024 arginine finger; other site 1168290002025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290002026 Walker A motif; other site 1168290002027 ATP binding site [chemical binding]; other site 1168290002028 Walker B motif; other site 1168290002029 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1168290002030 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1168290002031 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1168290002032 dimer interface [polypeptide binding]; other site 1168290002033 anticodon binding site; other site 1168290002034 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168290002035 motif 1; other site 1168290002036 dimer interface [polypeptide binding]; other site 1168290002037 active site 1168290002038 motif 2; other site 1168290002039 GAD domain; Region: GAD; pfam02938 1168290002040 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168290002041 active site 1168290002042 motif 3; other site 1168290002043 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1168290002044 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1168290002045 dimer interface [polypeptide binding]; other site 1168290002046 motif 1; other site 1168290002047 active site 1168290002048 motif 2; other site 1168290002049 motif 3; other site 1168290002050 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1168290002051 anticodon binding site; other site 1168290002052 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1168290002053 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1168290002054 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1168290002055 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168290002056 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1168290002057 catalytic site [active] 1168290002058 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1168290002059 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1168290002060 Walker A/P-loop; other site 1168290002061 ATP binding site [chemical binding]; other site 1168290002062 Q-loop/lid; other site 1168290002063 ABC transporter signature motif; other site 1168290002064 Walker B; other site 1168290002065 D-loop; other site 1168290002066 H-loop/switch region; other site 1168290002067 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168290002068 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1168290002069 substrate binding pocket [chemical binding]; other site 1168290002070 membrane-bound complex binding site; other site 1168290002071 hinge residues; other site 1168290002072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290002073 dimer interface [polypeptide binding]; other site 1168290002074 conserved gate region; other site 1168290002075 ABC-ATPase subunit interface; other site 1168290002076 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1168290002077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290002078 dimer interface [polypeptide binding]; other site 1168290002079 conserved gate region; other site 1168290002080 putative PBP binding loops; other site 1168290002081 ABC-ATPase subunit interface; other site 1168290002082 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1168290002083 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1168290002084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168290002085 ATP binding site [chemical binding]; other site 1168290002086 putative Mg++ binding site [ion binding]; other site 1168290002087 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290002088 nucleotide binding region [chemical binding]; other site 1168290002089 ATP-binding site [chemical binding]; other site 1168290002090 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1168290002091 recombination factor protein RarA; Reviewed; Region: PRK13342 1168290002092 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290002093 Walker A motif; other site 1168290002094 ATP binding site [chemical binding]; other site 1168290002095 Walker B motif; other site 1168290002096 arginine finger; other site 1168290002097 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1168290002098 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290002099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290002100 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168290002101 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1168290002102 acyl-activating enzyme (AAE) consensus motif; other site 1168290002103 putative AMP binding site [chemical binding]; other site 1168290002104 putative active site [active] 1168290002105 putative CoA binding site [chemical binding]; other site 1168290002106 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1168290002107 MULE transposase domain; Region: MULE; pfam10551 1168290002108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168290002109 Coenzyme A binding pocket [chemical binding]; other site 1168290002110 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1168290002111 hypothetical protein; Provisional; Region: PRK11770 1168290002112 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1168290002113 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1168290002114 Putative transcription activator [Transcription]; Region: TenA; COG0819 1168290002115 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1168290002116 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1168290002117 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1168290002118 active site 1168290002119 catalytic tetrad [active] 1168290002120 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168290002121 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1168290002122 Walker A/P-loop; other site 1168290002123 ATP binding site [chemical binding]; other site 1168290002124 Q-loop/lid; other site 1168290002125 ABC transporter signature motif; other site 1168290002126 Walker B; other site 1168290002127 D-loop; other site 1168290002128 H-loop/switch region; other site 1168290002129 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168290002130 Walker A/P-loop; other site 1168290002131 ATP binding site [chemical binding]; other site 1168290002132 Q-loop/lid; other site 1168290002133 ABC transporter signature motif; other site 1168290002134 Walker B; other site 1168290002135 D-loop; other site 1168290002136 H-loop/switch region; other site 1168290002137 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1168290002138 Predicted membrane protein [Function unknown]; Region: COG3601 1168290002139 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1168290002140 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168290002141 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1168290002142 nucleotide binding site [chemical binding]; other site 1168290002143 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290002144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290002145 homodimer interface [polypeptide binding]; other site 1168290002146 catalytic residue [active] 1168290002147 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168290002148 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290002149 Walker A/P-loop; other site 1168290002150 ATP binding site [chemical binding]; other site 1168290002151 Q-loop/lid; other site 1168290002152 ABC transporter signature motif; other site 1168290002153 Walker B; other site 1168290002154 D-loop; other site 1168290002155 H-loop/switch region; other site 1168290002156 Ligase N family; Region: LIGANc; smart00532 1168290002157 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1168290002158 nucleotide binding pocket [chemical binding]; other site 1168290002159 K-X-D-G motif; other site 1168290002160 catalytic site [active] 1168290002161 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1168290002162 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1168290002163 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1168290002164 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1168290002165 Dimer interface [polypeptide binding]; other site 1168290002166 Domain of unknown function DUF59; Region: DUF59; cl00941 1168290002167 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1168290002168 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1168290002169 glutamine synthetase, type I; Region: GlnA; TIGR00653 1168290002170 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1168290002171 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1168290002172 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1168290002173 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1168290002174 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168290002175 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168290002176 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1168290002177 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1168290002178 hypothetical protein; Provisional; Region: PRK07907 1168290002179 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1168290002180 active site 1168290002181 metal binding site [ion binding]; metal-binding site 1168290002182 dimer interface [polypeptide binding]; other site 1168290002183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168290002184 Histidine kinase; Region: HisKA_3; pfam07730 1168290002185 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1168290002186 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290002187 Q-loop/lid; other site 1168290002188 ABC transporter signature motif; other site 1168290002189 Walker B; other site 1168290002190 D-loop; other site 1168290002191 H-loop/switch region; other site 1168290002192 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1168290002193 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168290002194 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1168290002195 Walker A/P-loop; other site 1168290002196 ATP binding site [chemical binding]; other site 1168290002197 Q-loop/lid; other site 1168290002198 ABC transporter signature motif; other site 1168290002199 Walker B; other site 1168290002200 D-loop; other site 1168290002201 H-loop/switch region; other site 1168290002202 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168290002203 Walker A/P-loop; other site 1168290002204 ATP binding site [chemical binding]; other site 1168290002205 Q-loop/lid; other site 1168290002206 ABC transporter signature motif; other site 1168290002207 Walker B; other site 1168290002208 D-loop; other site 1168290002209 H-loop/switch region; other site 1168290002210 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1168290002211 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168290002212 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1168290002213 Walker A/P-loop; other site 1168290002214 ATP binding site [chemical binding]; other site 1168290002215 Q-loop/lid; other site 1168290002216 ABC transporter signature motif; other site 1168290002217 Walker B; other site 1168290002218 D-loop; other site 1168290002219 H-loop/switch region; other site 1168290002220 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1168290002221 FtsX-like permease family; Region: FtsX; pfam02687 1168290002222 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168290002223 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1168290002224 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168290002225 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1168290002226 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1168290002227 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1168290002228 dimer interface [polypeptide binding]; other site 1168290002229 motif 1; other site 1168290002230 active site 1168290002231 motif 2; other site 1168290002232 motif 3; other site 1168290002233 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1168290002234 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1168290002235 putative tRNA-binding site [nucleotide binding]; other site 1168290002236 B3/4 domain; Region: B3_4; pfam03483 1168290002237 tRNA synthetase B5 domain; Region: B5; smart00874 1168290002238 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1168290002239 dimer interface [polypeptide binding]; other site 1168290002240 motif 1; other site 1168290002241 motif 3; other site 1168290002242 motif 2; other site 1168290002243 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1168290002244 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1168290002245 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1168290002246 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1168290002247 heterotetramer interface [polypeptide binding]; other site 1168290002248 active site pocket [active] 1168290002249 cleavage site 1168290002250 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1168290002251 feedback inhibition sensing region; other site 1168290002252 homohexameric interface [polypeptide binding]; other site 1168290002253 nucleotide binding site [chemical binding]; other site 1168290002254 N-acetyl-L-glutamate binding site [chemical binding]; other site 1168290002255 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1168290002256 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1168290002257 inhibitor-cofactor binding pocket; inhibition site 1168290002258 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290002259 catalytic residue [active] 1168290002260 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1168290002261 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1168290002262 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1168290002263 arginine repressor; Provisional; Region: PRK03341 1168290002264 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1168290002265 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1168290002266 argininosuccinate synthase; Provisional; Region: PRK13820 1168290002267 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1168290002268 ANP binding site [chemical binding]; other site 1168290002269 Substrate Binding Site II [chemical binding]; other site 1168290002270 Substrate Binding Site I [chemical binding]; other site 1168290002271 argininosuccinate lyase; Provisional; Region: PRK00855 1168290002272 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1168290002273 active sites [active] 1168290002274 tetramer interface [polypeptide binding]; other site 1168290002275 acetoin reductases; Region: 23BDH; TIGR02415 1168290002276 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168290002277 NAD(P) binding site [chemical binding]; other site 1168290002278 active site 1168290002279 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168290002280 Zn2+ binding site [ion binding]; other site 1168290002281 Mg2+ binding site [ion binding]; other site 1168290002282 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1168290002283 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1168290002284 active site 1168290002285 HIGH motif; other site 1168290002286 dimer interface [polypeptide binding]; other site 1168290002287 KMSKS motif; other site 1168290002288 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168290002289 RNA binding surface [nucleotide binding]; other site 1168290002290 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1168290002291 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290002292 active site 1168290002293 motif I; other site 1168290002294 motif II; other site 1168290002295 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290002296 motif II; other site 1168290002297 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1168290002298 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168290002299 RNA binding surface [nucleotide binding]; other site 1168290002300 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168290002301 S-adenosylmethionine binding site [chemical binding]; other site 1168290002302 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1168290002303 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1168290002304 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1168290002305 TrkA-N domain; Region: TrkA_N; pfam02254 1168290002306 TrkA-C domain; Region: TrkA_C; pfam02080 1168290002307 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1168290002308 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1168290002309 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1168290002310 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1168290002311 Walker A/P-loop; other site 1168290002312 ATP binding site [chemical binding]; other site 1168290002313 Q-loop/lid; other site 1168290002314 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1168290002315 ABC transporter signature motif; other site 1168290002316 Walker B; other site 1168290002317 D-loop; other site 1168290002318 H-loop/switch region; other site 1168290002319 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1168290002320 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1168290002321 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290002322 motif II; other site 1168290002323 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1168290002324 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1168290002325 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290002326 catalytic residue [active] 1168290002327 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1168290002328 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1168290002329 putative catalytic cysteine [active] 1168290002330 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1168290002331 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1168290002332 active site 1168290002333 (T/H)XGH motif; other site 1168290002334 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1168290002335 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1168290002336 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168290002337 active site 1168290002338 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1168290002339 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1168290002340 Substrate binding site; other site 1168290002341 Mg++ binding site; other site 1168290002342 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1168290002343 active site 1168290002344 substrate binding site [chemical binding]; other site 1168290002345 CoA binding site [chemical binding]; other site 1168290002346 Oligomerisation domain; Region: Oligomerisation; pfam02410 1168290002347 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290002348 catalytic core [active] 1168290002349 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1168290002350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290002351 catalytic core [active] 1168290002352 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1168290002353 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1168290002354 Cl binding site [ion binding]; other site 1168290002355 oligomer interface [polypeptide binding]; other site 1168290002356 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168290002357 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1168290002358 substrate binding pocket [chemical binding]; other site 1168290002359 membrane-bound complex binding site; other site 1168290002360 hinge residues; other site 1168290002361 aminoacyl-tRNA ligase; Region: PLN02563 1168290002362 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168290002363 active site 1168290002364 HIGH motif; other site 1168290002365 nucleotide binding site [chemical binding]; other site 1168290002366 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168290002367 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1168290002368 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168290002369 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168290002370 active site 1168290002371 KMSKS motif; other site 1168290002372 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1168290002373 tRNA binding surface [nucleotide binding]; other site 1168290002374 Helix-hairpin-helix motif; Region: HHH; pfam00633 1168290002375 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1168290002376 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1168290002377 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1168290002378 Competence protein; Region: Competence; pfam03772 1168290002379 hypothetical protein; Reviewed; Region: PRK07914 1168290002380 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1168290002381 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1168290002382 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1168290002383 Glycoprotease family; Region: Peptidase_M22; pfam00814 1168290002384 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1168290002385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168290002386 Coenzyme A binding pocket [chemical binding]; other site 1168290002387 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1168290002388 UGMP family protein; Validated; Region: PRK09604 1168290002389 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1168290002390 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1168290002391 isocitrate dehydrogenase; Validated; Region: PRK08299 1168290002392 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1168290002393 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1168290002394 phosphate binding site [ion binding]; other site 1168290002395 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168290002396 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1168290002397 acyl-activating enzyme (AAE) consensus motif; other site 1168290002398 putative AMP binding site [chemical binding]; other site 1168290002399 putative active site [active] 1168290002400 putative CoA binding site [chemical binding]; other site 1168290002401 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1168290002402 active site 1168290002403 catalytic residues [active] 1168290002404 metal binding site [ion binding]; metal-binding site 1168290002405 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1168290002406 rRNA interaction site [nucleotide binding]; other site 1168290002407 S8 interaction site; other site 1168290002408 putative laminin-1 binding site; other site 1168290002409 elongation factor Ts; Provisional; Region: tsf; PRK09377 1168290002410 UBA/TS-N domain; Region: UBA; pfam00627 1168290002411 Elongation factor TS; Region: EF_TS; pfam00889 1168290002412 Elongation factor TS; Region: EF_TS; pfam00889 1168290002413 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1168290002414 putative nucleotide binding site [chemical binding]; other site 1168290002415 uridine monophosphate binding site [chemical binding]; other site 1168290002416 homohexameric interface [polypeptide binding]; other site 1168290002417 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1168290002418 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1168290002419 hinge region; other site 1168290002420 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1168290002421 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1168290002422 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1168290002423 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168290002424 FeS/SAM binding site; other site 1168290002425 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168290002426 WHG domain; Region: WHG; pfam13305 1168290002427 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1168290002428 Walker A/P-loop; other site 1168290002429 ATP binding site [chemical binding]; other site 1168290002430 ABC transporter; Region: ABC_tran; pfam00005 1168290002431 Q-loop/lid; other site 1168290002432 ABC transporter signature motif; other site 1168290002433 Walker B; other site 1168290002434 D-loop; other site 1168290002435 H-loop/switch region; other site 1168290002436 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1168290002437 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1168290002438 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1168290002439 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1168290002440 substrate binding site [chemical binding]; other site 1168290002441 glutamase interaction surface [polypeptide binding]; other site 1168290002442 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1168290002443 anthranilate synthase component I; Provisional; Region: PRK13571 1168290002444 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1168290002445 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1168290002446 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1168290002447 putative uracil binding site [chemical binding]; other site 1168290002448 putative active site [active] 1168290002449 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 1168290002450 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1168290002451 active site 1168290002452 ribulose/triose binding site [chemical binding]; other site 1168290002453 phosphate binding site [ion binding]; other site 1168290002454 substrate (anthranilate) binding pocket [chemical binding]; other site 1168290002455 product (indole) binding pocket [chemical binding]; other site 1168290002456 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1168290002457 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290002458 catalytic residue [active] 1168290002459 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1168290002460 substrate binding site [chemical binding]; other site 1168290002461 active site 1168290002462 catalytic residues [active] 1168290002463 heterodimer interface [polypeptide binding]; other site 1168290002464 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1168290002465 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1168290002466 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1168290002467 substrate binding site [chemical binding]; other site 1168290002468 hexamer interface [polypeptide binding]; other site 1168290002469 metal binding site [ion binding]; metal-binding site 1168290002470 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1168290002471 homodimer interface [polypeptide binding]; other site 1168290002472 putative metal binding site [ion binding]; other site 1168290002473 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1168290002474 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1168290002475 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1168290002476 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1168290002477 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1168290002478 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1168290002479 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1168290002480 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1168290002481 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168290002482 phosphopeptide binding site; other site 1168290002483 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1168290002484 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168290002485 DNA binding residues [nucleotide binding] 1168290002486 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1168290002487 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1168290002488 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290002489 motif II; other site 1168290002490 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1168290002491 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1168290002492 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168290002493 ATP binding site [chemical binding]; other site 1168290002494 putative Mg++ binding site [ion binding]; other site 1168290002495 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290002496 nucleotide binding region [chemical binding]; other site 1168290002497 ATP-binding site [chemical binding]; other site 1168290002498 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1168290002499 Predicted transcriptional regulator [Transcription]; Region: COG2378 1168290002500 WYL domain; Region: WYL; pfam13280 1168290002501 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168290002502 active site 1168290002503 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 1168290002504 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1168290002505 active site 1168290002506 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1168290002507 CMP-binding site; other site 1168290002508 The sites determining sugar specificity; other site 1168290002509 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1168290002510 G1 box; other site 1168290002511 GTP/Mg2+ binding site [chemical binding]; other site 1168290002512 Switch I region; other site 1168290002513 G2 box; other site 1168290002514 Switch II region; other site 1168290002515 G3 box; other site 1168290002516 G4 box; other site 1168290002517 G5 box; other site 1168290002518 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1168290002519 G1 box; other site 1168290002520 GTP/Mg2+ binding site [chemical binding]; other site 1168290002521 Switch I region; other site 1168290002522 G2 box; other site 1168290002523 G3 box; other site 1168290002524 Switch II region; other site 1168290002525 G4 box; other site 1168290002526 G5 box; other site 1168290002527 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1168290002528 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168290002529 RNA binding surface [nucleotide binding]; other site 1168290002530 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1168290002531 active site 1168290002532 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1168290002533 amphipathic channel; other site 1168290002534 Asn-Pro-Ala signature motifs; other site 1168290002535 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1168290002536 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1168290002537 purine monophosphate binding site [chemical binding]; other site 1168290002538 dimer interface [polypeptide binding]; other site 1168290002539 putative catalytic residues [active] 1168290002540 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1168290002541 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1168290002542 CoA binding domain; Region: CoA_binding; pfam02629 1168290002543 CoA-ligase; Region: Ligase_CoA; pfam00549 1168290002544 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1168290002545 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1168290002546 CoA-ligase; Region: Ligase_CoA; pfam00549 1168290002547 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168290002548 active site 1168290002549 Preprotein translocase subunit; Region: YajC; pfam02699 1168290002550 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1168290002551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290002552 Walker A motif; other site 1168290002553 ATP binding site [chemical binding]; other site 1168290002554 Walker B motif; other site 1168290002555 arginine finger; other site 1168290002556 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1168290002557 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1168290002558 RuvA N terminal domain; Region: RuvA_N; pfam01330 1168290002559 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1168290002560 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1168290002561 active site 1168290002562 putative DNA-binding cleft [nucleotide binding]; other site 1168290002563 dimer interface [polypeptide binding]; other site 1168290002564 hypothetical protein; Validated; Region: PRK00110 1168290002565 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168290002566 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168290002567 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK07920 1168290002568 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1168290002569 putative acyl-acceptor binding pocket; other site 1168290002570 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1168290002571 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1168290002572 thiS-thiF/thiG interaction site; other site 1168290002573 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1168290002574 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1168290002575 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1168290002576 active site 1168290002577 dimer interface [polypeptide binding]; other site 1168290002578 motif 1; other site 1168290002579 motif 2; other site 1168290002580 motif 3; other site 1168290002581 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1168290002582 anticodon binding site; other site 1168290002583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168290002584 ABC transporter; Region: ABC_tran; pfam00005 1168290002585 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1168290002586 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168290002587 Coenzyme A binding pocket [chemical binding]; other site 1168290002588 PAC2 family; Region: PAC2; pfam09754 1168290002589 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1168290002590 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1168290002591 chaperone protein DnaJ; Provisional; Region: PRK14278 1168290002592 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1168290002593 HSP70 interaction site [polypeptide binding]; other site 1168290002594 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1168290002595 Zn binding sites [ion binding]; other site 1168290002596 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1168290002597 dimer interface [polypeptide binding]; other site 1168290002598 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1168290002599 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1168290002600 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1168290002601 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1168290002602 TPP-binding site [chemical binding]; other site 1168290002603 dimer interface [polypeptide binding]; other site 1168290002604 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1168290002605 PYR/PP interface [polypeptide binding]; other site 1168290002606 dimer interface [polypeptide binding]; other site 1168290002607 TPP binding site [chemical binding]; other site 1168290002608 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1168290002609 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1168290002610 putative active site [active] 1168290002611 transaldolase; Provisional; Region: PRK03903 1168290002612 catalytic residue [active] 1168290002613 hypothetical protein; Validated; Region: PRK07682 1168290002614 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290002615 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290002616 homodimer interface [polypeptide binding]; other site 1168290002617 catalytic residue [active] 1168290002618 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1168290002619 AsnC family; Region: AsnC_trans_reg; pfam01037 1168290002620 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 1168290002621 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168290002622 non-specific DNA binding site [nucleotide binding]; other site 1168290002623 salt bridge; other site 1168290002624 sequence-specific DNA binding site [nucleotide binding]; other site 1168290002625 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290002626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290002627 homodimer interface [polypeptide binding]; other site 1168290002628 catalytic residue [active] 1168290002629 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1168290002630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290002631 active site 1168290002632 motif I; other site 1168290002633 motif II; other site 1168290002634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290002635 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1168290002636 triosephosphate isomerase; Provisional; Region: PRK14567 1168290002637 substrate binding site [chemical binding]; other site 1168290002638 dimer interface [polypeptide binding]; other site 1168290002639 catalytic triad [active] 1168290002640 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1168290002641 Phosphoglycerate kinase; Region: PGK; pfam00162 1168290002642 substrate binding site [chemical binding]; other site 1168290002643 hinge regions; other site 1168290002644 ADP binding site [chemical binding]; other site 1168290002645 catalytic site [active] 1168290002646 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1168290002647 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1168290002648 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1168290002649 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1168290002650 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1168290002651 shikimate binding site; other site 1168290002652 NAD(P) binding site [chemical binding]; other site 1168290002653 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 1168290002654 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1168290002655 GIY-YIG motif/motif A; other site 1168290002656 active site 1168290002657 catalytic site [active] 1168290002658 putative DNA binding site [nucleotide binding]; other site 1168290002659 metal binding site [ion binding]; metal-binding site 1168290002660 UvrB/uvrC motif; Region: UVR; pfam02151 1168290002661 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1168290002662 Helix-hairpin-helix motif; Region: HHH; pfam00633 1168290002663 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1168290002664 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1168290002665 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1168290002666 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1168290002667 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1168290002668 putative active site [active] 1168290002669 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1168290002670 Predicted esterase [General function prediction only]; Region: COG0400 1168290002671 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1168290002672 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290002673 Walker A/P-loop; other site 1168290002674 ATP binding site [chemical binding]; other site 1168290002675 Q-loop/lid; other site 1168290002676 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168290002677 ABC transporter signature motif; other site 1168290002678 Walker B; other site 1168290002679 D-loop; other site 1168290002680 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1168290002681 Cation efflux family; Region: Cation_efflux; pfam01545 1168290002682 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1168290002683 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1168290002684 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1168290002685 active site 1168290002686 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1168290002687 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1168290002688 putative substrate binding site [chemical binding]; other site 1168290002689 putative ATP binding site [chemical binding]; other site 1168290002690 peroxiredoxin; Region: AhpC; TIGR03137 1168290002691 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1168290002692 dimer interface [polypeptide binding]; other site 1168290002693 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1168290002694 catalytic triad [active] 1168290002695 peroxidatic and resolving cysteines [active] 1168290002696 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1168290002697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168290002698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168290002699 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1168290002700 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1168290002701 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1168290002702 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1168290002703 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1168290002704 dimerization interface [polypeptide binding]; other site 1168290002705 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1168290002706 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290002707 motif II; other site 1168290002708 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1168290002709 Predicted transcriptional regulators [Transcription]; Region: COG1733 1168290002710 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1168290002711 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1168290002712 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168290002713 Coenzyme A binding pocket [chemical binding]; other site 1168290002714 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168290002715 active site 1168290002716 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1168290002717 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1168290002718 heterodimer interface [polypeptide binding]; other site 1168290002719 active site 1168290002720 FMN binding site [chemical binding]; other site 1168290002721 homodimer interface [polypeptide binding]; other site 1168290002722 substrate binding site [chemical binding]; other site 1168290002723 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1168290002724 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1168290002725 FAD binding pocket [chemical binding]; other site 1168290002726 FAD binding motif [chemical binding]; other site 1168290002727 phosphate binding motif [ion binding]; other site 1168290002728 beta-alpha-beta structure motif; other site 1168290002729 NAD binding pocket [chemical binding]; other site 1168290002730 Iron coordination center [ion binding]; other site 1168290002731 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1168290002732 active site 1168290002733 dimer interface [polypeptide binding]; other site 1168290002734 dihydroorotase; Validated; Region: pyrC; PRK09357 1168290002735 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1168290002736 active site 1168290002737 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1168290002738 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1168290002739 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1168290002740 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1168290002741 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1168290002742 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1168290002743 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1168290002744 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1168290002745 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168290002746 metal binding triad; other site 1168290002747 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1168290002748 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1168290002749 metal binding triad; other site 1168290002750 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1168290002751 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1168290002752 FAD binding site [chemical binding]; other site 1168290002753 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1168290002754 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1168290002755 THF binding site; other site 1168290002756 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1168290002757 substrate binding site [chemical binding]; other site 1168290002758 THF binding site; other site 1168290002759 zinc-binding site [ion binding]; other site 1168290002760 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290002761 catalytic core [active] 1168290002762 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1168290002763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168290002764 S-adenosylmethionine binding site [chemical binding]; other site 1168290002765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290002766 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1168290002767 Walker A/P-loop; other site 1168290002768 ATP binding site [chemical binding]; other site 1168290002769 Q-loop/lid; other site 1168290002770 ABC transporter signature motif; other site 1168290002771 Walker B; other site 1168290002772 D-loop; other site 1168290002773 H-loop/switch region; other site 1168290002774 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1168290002775 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168290002776 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1168290002777 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1168290002778 catalytic triad [active] 1168290002779 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1168290002780 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168290002781 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1168290002782 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1168290002783 active site 1168290002784 dimer interface [polypeptide binding]; other site 1168290002785 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1168290002786 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1168290002787 active site 1168290002788 FMN binding site [chemical binding]; other site 1168290002789 substrate binding site [chemical binding]; other site 1168290002790 3Fe-4S cluster binding site [ion binding]; other site 1168290002791 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1168290002792 domain interface; other site 1168290002793 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1168290002794 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168290002795 FeS/SAM binding site; other site 1168290002796 HemN C-terminal domain; Region: HemN_C; pfam06969 1168290002797 GTP-binding protein LepA; Provisional; Region: PRK05433 1168290002798 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1168290002799 G1 box; other site 1168290002800 putative GEF interaction site [polypeptide binding]; other site 1168290002801 GTP/Mg2+ binding site [chemical binding]; other site 1168290002802 Switch I region; other site 1168290002803 G2 box; other site 1168290002804 G3 box; other site 1168290002805 Switch II region; other site 1168290002806 G4 box; other site 1168290002807 G5 box; other site 1168290002808 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1168290002809 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1168290002810 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1168290002811 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1168290002812 UPF0126 domain; Region: UPF0126; pfam03458 1168290002813 Predicted membrane protein [Function unknown]; Region: COG2860 1168290002814 UPF0126 domain; Region: UPF0126; pfam03458 1168290002815 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1168290002816 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1168290002817 homodimer interface [polypeptide binding]; other site 1168290002818 substrate-cofactor binding pocket; other site 1168290002819 catalytic residue [active] 1168290002820 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1168290002821 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1168290002822 5S rRNA interface [nucleotide binding]; other site 1168290002823 CTC domain interface [polypeptide binding]; other site 1168290002824 L16 interface [polypeptide binding]; other site 1168290002825 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168290002826 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1168290002827 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1168290002828 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1168290002829 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1168290002830 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1168290002831 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1168290002832 ligand binding site [chemical binding]; other site 1168290002833 homodimer interface [polypeptide binding]; other site 1168290002834 NAD(P) binding site [chemical binding]; other site 1168290002835 trimer interface B [polypeptide binding]; other site 1168290002836 trimer interface A [polypeptide binding]; other site 1168290002837 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168290002838 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1168290002839 acyl-activating enzyme (AAE) consensus motif; other site 1168290002840 putative AMP binding site [chemical binding]; other site 1168290002841 putative active site [active] 1168290002842 putative CoA binding site [chemical binding]; other site 1168290002843 GTPase Era; Reviewed; Region: era; PRK00089 1168290002844 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1168290002845 G1 box; other site 1168290002846 GTP/Mg2+ binding site [chemical binding]; other site 1168290002847 Switch I region; other site 1168290002848 G2 box; other site 1168290002849 Switch II region; other site 1168290002850 G3 box; other site 1168290002851 G4 box; other site 1168290002852 G5 box; other site 1168290002853 KH domain; Region: KH_2; pfam07650 1168290002854 Domain of unknown function DUF21; Region: DUF21; pfam01595 1168290002855 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1168290002856 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1168290002857 Transporter associated domain; Region: CorC_HlyC; smart01091 1168290002858 metal-binding heat shock protein; Provisional; Region: PRK00016 1168290002859 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1168290002860 PhoH-like protein; Region: PhoH; pfam02562 1168290002861 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1168290002862 nucleotide binding site/active site [active] 1168290002863 HIT family signature motif; other site 1168290002864 catalytic residue [active] 1168290002865 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1168290002866 RNA methyltransferase, RsmE family; Region: TIGR00046 1168290002867 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168290002868 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1168290002869 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168290002870 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1168290002871 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1168290002872 ligand binding site; other site 1168290002873 oligomer interface; other site 1168290002874 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1168290002875 dimer interface [polypeptide binding]; other site 1168290002876 N-terminal domain interface [polypeptide binding]; other site 1168290002877 sulfate 1 binding site; other site 1168290002878 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1168290002879 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1168290002880 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1168290002881 trimerization site [polypeptide binding]; other site 1168290002882 active site 1168290002883 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1168290002884 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1168290002885 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1168290002886 catalytic residue [active] 1168290002887 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1168290002888 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1168290002889 Walker A/P-loop; other site 1168290002890 ATP binding site [chemical binding]; other site 1168290002891 Q-loop/lid; other site 1168290002892 ABC transporter signature motif; other site 1168290002893 Walker B; other site 1168290002894 D-loop; other site 1168290002895 H-loop/switch region; other site 1168290002896 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1168290002897 FeS assembly protein SufD; Region: sufD; TIGR01981 1168290002898 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1168290002899 FeS assembly protein SufB; Region: sufB; TIGR01980 1168290002900 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1168290002901 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1168290002902 CTP synthetase; Validated; Region: pyrG; PRK05380 1168290002903 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1168290002904 Catalytic site [active] 1168290002905 active site 1168290002906 UTP binding site [chemical binding]; other site 1168290002907 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1168290002908 active site 1168290002909 putative oxyanion hole; other site 1168290002910 catalytic triad [active] 1168290002911 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1168290002912 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1168290002913 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1168290002914 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1168290002915 active site 1168290002916 catalytic site [active] 1168290002917 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1168290002918 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1168290002919 active site 1168290002920 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1168290002921 catalytic nucleophile [active] 1168290002922 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 1168290002923 GIY-YIG motif/motif A; other site 1168290002924 putative active site [active] 1168290002925 putative metal binding site [ion binding]; other site 1168290002926 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1168290002927 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1168290002928 trimer interface [polypeptide binding]; other site 1168290002929 active site 1168290002930 dimer interface [polypeptide binding]; other site 1168290002931 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 1168290002932 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1168290002933 ADP binding site [chemical binding]; other site 1168290002934 magnesium binding site [ion binding]; other site 1168290002935 putative shikimate binding site; other site 1168290002936 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1168290002937 active site 1168290002938 dimer interface [polypeptide binding]; other site 1168290002939 metal binding site [ion binding]; metal-binding site 1168290002940 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1168290002941 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1168290002942 Tetramer interface [polypeptide binding]; other site 1168290002943 active site 1168290002944 FMN-binding site [chemical binding]; other site 1168290002945 YceG-like family; Region: YceG; pfam02618 1168290002946 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1168290002947 dimerization interface [polypeptide binding]; other site 1168290002948 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1168290002949 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1168290002950 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1168290002951 motif 1; other site 1168290002952 active site 1168290002953 motif 2; other site 1168290002954 motif 3; other site 1168290002955 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1168290002956 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290002957 catalytic core [active] 1168290002958 Membrane protein of unknown function; Region: DUF360; pfam04020 1168290002959 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1168290002960 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1168290002961 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1168290002962 RNA binding surface [nucleotide binding]; other site 1168290002963 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1168290002964 Part of AAA domain; Region: AAA_19; pfam13245 1168290002965 Family description; Region: UvrD_C_2; pfam13538 1168290002966 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168290002967 active site 1168290002968 xanthine permease; Region: pbuX; TIGR03173 1168290002969 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 1168290002970 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1168290002971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290002972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290002973 homodimer interface [polypeptide binding]; other site 1168290002974 catalytic residue [active] 1168290002975 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1168290002976 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1168290002977 active site 1168290002978 Na/Ca binding site [ion binding]; other site 1168290002979 catalytic site [active] 1168290002980 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1168290002981 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1168290002982 catalytic triad [active] 1168290002983 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1168290002984 putative deacylase active site [active] 1168290002985 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1168290002986 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1168290002987 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1168290002988 Walker A/P-loop; other site 1168290002989 ATP binding site [chemical binding]; other site 1168290002990 Q-loop/lid; other site 1168290002991 ABC transporter signature motif; other site 1168290002992 Walker B; other site 1168290002993 D-loop; other site 1168290002994 H-loop/switch region; other site 1168290002995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168290002996 DNA-binding site [nucleotide binding]; DNA binding site 1168290002997 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1168290002998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168290002999 non-specific DNA binding site [nucleotide binding]; other site 1168290003000 salt bridge; other site 1168290003001 sequence-specific DNA binding site [nucleotide binding]; other site 1168290003002 adenosine deaminase; Provisional; Region: PRK09358 1168290003003 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1168290003004 active site 1168290003005 Chorismate mutase type II; Region: CM_2; cl00693 1168290003006 hypothetical protein; Provisional; Region: PRK06761 1168290003007 hypothetical protein; Provisional; Region: PRK06761 1168290003008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168290003009 Coenzyme A binding pocket [chemical binding]; other site 1168290003010 AAA domain; Region: AAA_17; pfam13207 1168290003011 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1168290003012 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1168290003013 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1168290003014 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1168290003015 G1 box; other site 1168290003016 putative GEF interaction site [polypeptide binding]; other site 1168290003017 GTP/Mg2+ binding site [chemical binding]; other site 1168290003018 Switch I region; other site 1168290003019 G2 box; other site 1168290003020 G3 box; other site 1168290003021 Switch II region; other site 1168290003022 G4 box; other site 1168290003023 G5 box; other site 1168290003024 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1168290003025 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1168290003026 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1168290003027 Transposase domain (DUF772); Region: DUF772; pfam05598 1168290003028 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1168290003029 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1168290003030 GMP synthase; Reviewed; Region: guaA; PRK00074 1168290003031 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1168290003032 AMP/PPi binding site [chemical binding]; other site 1168290003033 candidate oxyanion hole; other site 1168290003034 catalytic triad [active] 1168290003035 potential glutamine specificity residues [chemical binding]; other site 1168290003036 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1168290003037 ATP Binding subdomain [chemical binding]; other site 1168290003038 Ligand Binding sites [chemical binding]; other site 1168290003039 Dimerization subdomain; other site 1168290003040 putative phosphoketolase; Provisional; Region: PRK05261 1168290003041 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1168290003042 TPP-binding site; other site 1168290003043 XFP C-terminal domain; Region: XFP_C; pfam09363 1168290003044 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1168290003045 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1168290003046 propionate/acetate kinase; Provisional; Region: PRK12379 1168290003047 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1168290003048 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1168290003049 hinge; other site 1168290003050 active site 1168290003051 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1168290003052 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1168290003053 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1168290003054 active site 1168290003055 catalytic site [active] 1168290003056 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1168290003057 dimer interface [polypeptide binding]; other site 1168290003058 ADP-ribose binding site [chemical binding]; other site 1168290003059 active site 1168290003060 nudix motif; other site 1168290003061 metal binding site [ion binding]; metal-binding site 1168290003062 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1168290003063 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1168290003064 DNA polymerase I; Provisional; Region: PRK05755 1168290003065 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1168290003066 active site 1168290003067 metal binding site 1 [ion binding]; metal-binding site 1168290003068 putative 5' ssDNA interaction site; other site 1168290003069 metal binding site 3; metal-binding site 1168290003070 metal binding site 2 [ion binding]; metal-binding site 1168290003071 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1168290003072 putative DNA binding site [nucleotide binding]; other site 1168290003073 putative metal binding site [ion binding]; other site 1168290003074 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1168290003075 active site 1168290003076 substrate binding site [chemical binding]; other site 1168290003077 catalytic site [active] 1168290003078 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1168290003079 active site 1168290003080 DNA binding site [nucleotide binding] 1168290003081 catalytic site [active] 1168290003082 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1168290003083 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168290003084 active site 1168290003085 phosphorylation site [posttranslational modification] 1168290003086 intermolecular recognition site; other site 1168290003087 dimerization interface [polypeptide binding]; other site 1168290003088 ANTAR domain; Region: ANTAR; pfam03861 1168290003089 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1168290003090 dimer interface [polypeptide binding]; other site 1168290003091 ADP-ribose binding site [chemical binding]; other site 1168290003092 active site 1168290003093 nudix motif; other site 1168290003094 metal binding site [ion binding]; metal-binding site 1168290003095 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1168290003096 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1168290003097 active site 1168290003098 domain interfaces; other site 1168290003099 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1168290003100 excinuclease ABC subunit B; Provisional; Region: PRK05298 1168290003101 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168290003102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290003103 nucleotide binding region [chemical binding]; other site 1168290003104 ATP-binding site [chemical binding]; other site 1168290003105 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1168290003106 UvrB/uvrC motif; Region: UVR; pfam02151 1168290003107 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1168290003108 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1168290003109 CoA-binding site [chemical binding]; other site 1168290003110 ATP-binding [chemical binding]; other site 1168290003111 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1168290003112 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1168290003113 RNA binding site [nucleotide binding]; other site 1168290003114 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1168290003115 RNA binding site [nucleotide binding]; other site 1168290003116 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1168290003117 RNA binding site [nucleotide binding]; other site 1168290003118 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1168290003119 RNA binding site [nucleotide binding]; other site 1168290003120 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1168290003121 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1168290003122 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1168290003123 homodimer interface [polypeptide binding]; other site 1168290003124 NADP binding site [chemical binding]; other site 1168290003125 substrate binding site [chemical binding]; other site 1168290003126 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1168290003127 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1168290003128 intersubunit interface [polypeptide binding]; other site 1168290003129 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1168290003130 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1168290003131 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1168290003132 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1168290003133 ABC-ATPase subunit interface; other site 1168290003134 dimer interface [polypeptide binding]; other site 1168290003135 putative PBP binding regions; other site 1168290003136 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1168290003137 homotrimer interaction site [polypeptide binding]; other site 1168290003138 zinc binding site [ion binding]; other site 1168290003139 CDP-binding sites; other site 1168290003140 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1168290003141 glycogen branching enzyme; Provisional; Region: PRK05402 1168290003142 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1168290003143 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1168290003144 active site 1168290003145 catalytic site [active] 1168290003146 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1168290003147 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168290003148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168290003149 active site 1168290003150 phosphorylation site [posttranslational modification] 1168290003151 intermolecular recognition site; other site 1168290003152 dimerization interface [polypeptide binding]; other site 1168290003153 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168290003154 DNA binding site [nucleotide binding] 1168290003155 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1168290003156 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1168290003157 dimerization interface [polypeptide binding]; other site 1168290003158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1168290003159 dimer interface [polypeptide binding]; other site 1168290003160 phosphorylation site [posttranslational modification] 1168290003161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168290003162 ATP binding site [chemical binding]; other site 1168290003163 Mg2+ binding site [ion binding]; other site 1168290003164 G-X-G motif; other site 1168290003165 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168290003166 active site 1168290003167 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1168290003168 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1168290003169 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1168290003170 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1168290003171 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1168290003172 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1168290003173 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168290003174 Transcription factor WhiB; Region: Whib; pfam02467 1168290003175 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1168290003176 PAS fold; Region: PAS_4; pfam08448 1168290003177 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1168290003178 Histidine kinase; Region: HisKA_2; pfam07568 1168290003179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168290003180 ATP binding site [chemical binding]; other site 1168290003181 Mg2+ binding site [ion binding]; other site 1168290003182 G-X-G motif; other site 1168290003183 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1168290003184 Haemolysin-III related; Region: HlyIII; pfam03006 1168290003185 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1168290003186 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1168290003187 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1168290003188 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1168290003189 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1168290003190 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1168290003191 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1168290003192 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1168290003193 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1168290003194 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1168290003195 Septum formation initiator; Region: DivIC; pfam04977 1168290003196 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1168290003197 enolase; Provisional; Region: eno; PRK00077 1168290003198 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1168290003199 dimer interface [polypeptide binding]; other site 1168290003200 metal binding site [ion binding]; metal-binding site 1168290003201 substrate binding pocket [chemical binding]; other site 1168290003202 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1168290003203 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290003204 dimer interface [polypeptide binding]; other site 1168290003205 conserved gate region; other site 1168290003206 putative PBP binding loops; other site 1168290003207 ABC-ATPase subunit interface; other site 1168290003208 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1168290003209 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1168290003210 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1168290003211 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1168290003212 Walker A/P-loop; other site 1168290003213 ATP binding site [chemical binding]; other site 1168290003214 Q-loop/lid; other site 1168290003215 ABC transporter signature motif; other site 1168290003216 Walker B; other site 1168290003217 D-loop; other site 1168290003218 H-loop/switch region; other site 1168290003219 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1168290003220 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1168290003221 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168290003222 ATP binding site [chemical binding]; other site 1168290003223 putative Mg++ binding site [ion binding]; other site 1168290003224 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290003225 nucleotide binding region [chemical binding]; other site 1168290003226 ATP-binding site [chemical binding]; other site 1168290003227 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1168290003228 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1168290003229 putative active site [active] 1168290003230 catalytic residue [active] 1168290003231 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1168290003232 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168290003233 Coenzyme A binding pocket [chemical binding]; other site 1168290003234 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1168290003235 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1168290003236 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1168290003237 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1168290003238 Protein of unknown function (DUF466); Region: DUF466; cl01082 1168290003239 carbon starvation protein A; Provisional; Region: PRK15015 1168290003240 Carbon starvation protein CstA; Region: CstA; pfam02554 1168290003241 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1168290003242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290003243 H-loop/switch region; other site 1168290003244 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290003245 ABC transporter signature motif; other site 1168290003246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1168290003247 Q-loop/lid; other site 1168290003248 ABC transporter signature motif; other site 1168290003249 Walker B; other site 1168290003250 D-loop; other site 1168290003251 H-loop/switch region; other site 1168290003252 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1168290003253 MarR family; Region: MarR_2; pfam12802 1168290003254 Ubinuclein conserved middle domain; Region: UBN_AB; pfam14075 1168290003255 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1168290003256 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1168290003257 Aspartase; Region: Aspartase; cd01357 1168290003258 active sites [active] 1168290003259 tetramer interface [polypeptide binding]; other site 1168290003260 FeoA domain; Region: FeoA; pfam04023 1168290003261 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1168290003262 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1168290003263 G1 box; other site 1168290003264 GTP/Mg2+ binding site [chemical binding]; other site 1168290003265 Switch I region; other site 1168290003266 G2 box; other site 1168290003267 G3 box; other site 1168290003268 Switch II region; other site 1168290003269 G4 box; other site 1168290003270 G5 box; other site 1168290003271 Nucleoside recognition; Region: Gate; pfam07670 1168290003272 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1168290003273 Nucleoside recognition; Region: Gate; pfam07670 1168290003274 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1168290003275 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1168290003276 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1168290003277 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1168290003278 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1168290003279 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1168290003280 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1168290003281 putative active site [active] 1168290003282 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1168290003283 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1168290003284 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1168290003285 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1168290003286 catalytic triad [active] 1168290003287 active site nucleophile [active] 1168290003288 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1168290003289 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1168290003290 SelR domain; Region: SelR; pfam01641 1168290003291 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1168290003292 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1168290003293 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1168290003294 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168290003295 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1168290003296 Uncharacterized conserved protein [Function unknown]; Region: COG3350 1168290003297 classical (c) SDRs; Region: SDR_c; cd05233 1168290003298 NAD(P) binding site [chemical binding]; other site 1168290003299 active site 1168290003300 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1168290003301 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1168290003302 ATP binding site [chemical binding]; other site 1168290003303 Mg++ binding site [ion binding]; other site 1168290003304 motif III; other site 1168290003305 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290003306 nucleotide binding region [chemical binding]; other site 1168290003307 ATP-binding site [chemical binding]; other site 1168290003308 Predicted membrane protein [Function unknown]; Region: COG2855 1168290003309 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1168290003310 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1168290003311 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1168290003312 substrate binding pocket [chemical binding]; other site 1168290003313 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1168290003314 GTP-binding protein YchF; Reviewed; Region: PRK09601 1168290003315 YchF GTPase; Region: YchF; cd01900 1168290003316 G1 box; other site 1168290003317 GTP/Mg2+ binding site [chemical binding]; other site 1168290003318 Switch I region; other site 1168290003319 G2 box; other site 1168290003320 Switch II region; other site 1168290003321 G3 box; other site 1168290003322 G4 box; other site 1168290003323 G5 box; other site 1168290003324 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1168290003325 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1168290003326 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1168290003327 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1168290003328 Histidine kinase; Region: HisKA_3; pfam07730 1168290003329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168290003330 ATP binding site [chemical binding]; other site 1168290003331 Mg2+ binding site [ion binding]; other site 1168290003332 G-X-G motif; other site 1168290003333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168290003334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168290003335 active site 1168290003336 phosphorylation site [posttranslational modification] 1168290003337 intermolecular recognition site; other site 1168290003338 dimerization interface [polypeptide binding]; other site 1168290003339 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168290003340 DNA binding residues [nucleotide binding] 1168290003341 dimerization interface [polypeptide binding]; other site 1168290003342 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1168290003343 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1168290003344 FtsX-like permease family; Region: FtsX; pfam02687 1168290003345 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168290003346 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1168290003347 Walker A/P-loop; other site 1168290003348 ATP binding site [chemical binding]; other site 1168290003349 Q-loop/lid; other site 1168290003350 ABC transporter signature motif; other site 1168290003351 Walker B; other site 1168290003352 D-loop; other site 1168290003353 H-loop/switch region; other site 1168290003354 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1168290003355 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1168290003356 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168290003357 Walker A/P-loop; other site 1168290003358 ATP binding site [chemical binding]; other site 1168290003359 Q-loop/lid; other site 1168290003360 ABC transporter signature motif; other site 1168290003361 Walker B; other site 1168290003362 D-loop; other site 1168290003363 H-loop/switch region; other site 1168290003364 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1168290003365 Walker A/P-loop; other site 1168290003366 ATP binding site [chemical binding]; other site 1168290003367 Q-loop/lid; other site 1168290003368 ABC transporter signature motif; other site 1168290003369 Walker B; other site 1168290003370 D-loop; other site 1168290003371 H-loop/switch region; other site 1168290003372 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1168290003373 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1168290003374 homodimer interface [polypeptide binding]; other site 1168290003375 substrate-cofactor binding pocket; other site 1168290003376 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290003377 catalytic residue [active] 1168290003378 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1168290003379 dimer interface [polypeptide binding]; other site 1168290003380 pyridoxal binding site [chemical binding]; other site 1168290003381 ATP binding site [chemical binding]; other site 1168290003382 hypothetical protein; Provisional; Region: PRK14681 1168290003383 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1168290003384 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1168290003385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290003386 Walker A motif; other site 1168290003387 ATP binding site [chemical binding]; other site 1168290003388 Walker B motif; other site 1168290003389 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1168290003390 DNA protecting protein DprA; Region: dprA; TIGR00732 1168290003391 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1168290003392 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1168290003393 L-aspartate oxidase; Provisional; Region: PRK06175 1168290003394 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1168290003395 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1168290003396 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1168290003397 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1168290003398 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168290003399 S-adenosylmethionine binding site [chemical binding]; other site 1168290003400 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1168290003401 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1168290003402 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1168290003403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290003404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290003405 homodimer interface [polypeptide binding]; other site 1168290003406 catalytic residue [active] 1168290003407 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1168290003408 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1168290003409 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290003410 Walker A motif; other site 1168290003411 ATP binding site [chemical binding]; other site 1168290003412 Walker B motif; other site 1168290003413 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1168290003414 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1168290003415 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1168290003416 oligomer interface [polypeptide binding]; other site 1168290003417 active site residues [active] 1168290003418 Clp protease; Region: CLP_protease; pfam00574 1168290003419 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1168290003420 oligomer interface [polypeptide binding]; other site 1168290003421 active site residues [active] 1168290003422 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1168290003423 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1168290003424 putative ion selectivity filter; other site 1168290003425 putative pore gating glutamate residue; other site 1168290003426 trigger factor; Provisional; Region: tig; PRK01490 1168290003427 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1168290003428 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1168290003429 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1168290003430 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1168290003431 active site 1168290003432 catalytic site [active] 1168290003433 substrate binding site [chemical binding]; other site 1168290003434 HRDC domain; Region: HRDC; pfam00570 1168290003435 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1168290003436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168290003437 FeS/SAM binding site; other site 1168290003438 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1168290003439 Pyruvate formate lyase 1; Region: PFL1; cd01678 1168290003440 coenzyme A binding site [chemical binding]; other site 1168290003441 active site 1168290003442 catalytic residues [active] 1168290003443 glycine loop; other site 1168290003444 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1168290003445 NAD synthetase; Provisional; Region: PRK13981 1168290003446 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1168290003447 multimer interface [polypeptide binding]; other site 1168290003448 active site 1168290003449 catalytic triad [active] 1168290003450 protein interface 1 [polypeptide binding]; other site 1168290003451 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1168290003452 homodimer interface [polypeptide binding]; other site 1168290003453 NAD binding pocket [chemical binding]; other site 1168290003454 ATP binding pocket [chemical binding]; other site 1168290003455 Mg binding site [ion binding]; other site 1168290003456 active-site loop [active] 1168290003457 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1168290003458 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1168290003459 metal binding site [ion binding]; metal-binding site 1168290003460 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290003461 conserved gate region; other site 1168290003462 ABC-ATPase subunit interface; other site 1168290003463 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1168290003464 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1168290003465 Walker A/P-loop; other site 1168290003466 ATP binding site [chemical binding]; other site 1168290003467 Q-loop/lid; other site 1168290003468 ABC transporter signature motif; other site 1168290003469 Walker B; other site 1168290003470 D-loop; other site 1168290003471 H-loop/switch region; other site 1168290003472 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1168290003473 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1168290003474 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1168290003475 active site 1168290003476 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1168290003477 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168290003478 Zn2+ binding site [ion binding]; other site 1168290003479 Mg2+ binding site [ion binding]; other site 1168290003480 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1168290003481 synthetase active site [active] 1168290003482 NTP binding site [chemical binding]; other site 1168290003483 metal binding site [ion binding]; metal-binding site 1168290003484 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1168290003485 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1168290003486 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1168290003487 trimer interface [polypeptide binding]; other site 1168290003488 active site 1168290003489 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1168290003490 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1168290003491 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1168290003492 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1168290003493 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1168290003494 CAP-like domain; other site 1168290003495 active site 1168290003496 primary dimer interface [polypeptide binding]; other site 1168290003497 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1168290003498 EamA-like transporter family; Region: EamA; cl17759 1168290003499 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1168290003500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168290003501 ATP binding site [chemical binding]; other site 1168290003502 putative Mg++ binding site [ion binding]; other site 1168290003503 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1168290003504 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290003505 nucleotide binding region [chemical binding]; other site 1168290003506 ATP-binding site [chemical binding]; other site 1168290003507 DEAD/H associated; Region: DEAD_assoc; pfam08494 1168290003508 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290003509 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290003510 putative substrate translocation pore; other site 1168290003511 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1168290003512 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1168290003513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1168290003514 ATP binding site [chemical binding]; other site 1168290003515 Mg2+ binding site [ion binding]; other site 1168290003516 G-X-G motif; other site 1168290003517 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1168290003518 anchoring element; other site 1168290003519 dimer interface [polypeptide binding]; other site 1168290003520 ATP binding site [chemical binding]; other site 1168290003521 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1168290003522 active site 1168290003523 putative metal-binding site [ion binding]; other site 1168290003524 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1168290003525 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1168290003526 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1168290003527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168290003528 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1168290003529 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168290003530 DNA binding residues [nucleotide binding] 1168290003531 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1168290003532 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1168290003533 substrate binding pocket [chemical binding]; other site 1168290003534 chain length determination region; other site 1168290003535 substrate-Mg2+ binding site; other site 1168290003536 catalytic residues [active] 1168290003537 aspartate-rich region 1; other site 1168290003538 active site lid residues [active] 1168290003539 aspartate-rich region 2; other site 1168290003540 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168290003541 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168290003542 active site 1168290003543 ATP binding site [chemical binding]; other site 1168290003544 substrate binding site [chemical binding]; other site 1168290003545 activation loop (A-loop); other site 1168290003546 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168290003547 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168290003548 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1168290003549 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1168290003550 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1168290003551 putative acyl-acceptor binding pocket; other site 1168290003552 TrbC/VIRB2 family; Region: TrbC; pfam04956 1168290003553 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1168290003554 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1168290003555 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1168290003556 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1168290003557 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1168290003558 ATP binding site [chemical binding]; other site 1168290003559 putative Mg++ binding site [ion binding]; other site 1168290003560 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1168290003561 SEC-C motif; Region: SEC-C; pfam02810 1168290003562 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1168290003563 30S subunit binding site; other site 1168290003564 RecX family; Region: RecX; pfam02631 1168290003565 recombinase A; Provisional; Region: recA; PRK09354 1168290003566 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1168290003567 hexamer interface [polypeptide binding]; other site 1168290003568 Walker A motif; other site 1168290003569 ATP binding site [chemical binding]; other site 1168290003570 Walker B motif; other site 1168290003571 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1168290003572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1168290003573 non-specific DNA binding site [nucleotide binding]; other site 1168290003574 salt bridge; other site 1168290003575 sequence-specific DNA binding site [nucleotide binding]; other site 1168290003576 Competence-damaged protein; Region: CinA; pfam02464 1168290003577 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1168290003578 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1168290003579 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1168290003580 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1168290003581 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1168290003582 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1168290003583 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1168290003584 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1168290003585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168290003586 FeS/SAM binding site; other site 1168290003587 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1168290003588 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1168290003589 synthetase active site [active] 1168290003590 NTP binding site [chemical binding]; other site 1168290003591 metal binding site [ion binding]; metal-binding site 1168290003592 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1168290003593 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1168290003594 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1168290003595 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168290003596 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1168290003597 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1168290003598 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1168290003599 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290003600 Walker A/P-loop; other site 1168290003601 ATP binding site [chemical binding]; other site 1168290003602 Q-loop/lid; other site 1168290003603 ABC transporter signature motif; other site 1168290003604 Walker B; other site 1168290003605 D-loop; other site 1168290003606 H-loop/switch region; other site 1168290003607 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168290003608 Histidine kinase; Region: HisKA_3; pfam07730 1168290003609 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168290003610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168290003611 active site 1168290003612 phosphorylation site [posttranslational modification] 1168290003613 intermolecular recognition site; other site 1168290003614 dimerization interface [polypeptide binding]; other site 1168290003615 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168290003616 DNA binding residues [nucleotide binding] 1168290003617 dimerization interface [polypeptide binding]; other site 1168290003618 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1168290003619 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1168290003620 Protein of unknown function DUF262; Region: DUF262; pfam03235 1168290003621 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1168290003622 Protein of unknown function DUF262; Region: DUF262; pfam03235 1168290003623 maltose O-acetyltransferase; Provisional; Region: PRK10092 1168290003624 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1168290003625 active site 1168290003626 substrate binding site [chemical binding]; other site 1168290003627 trimer interface [polypeptide binding]; other site 1168290003628 CoA binding site [chemical binding]; other site 1168290003629 aconitate hydratase; Validated; Region: PRK09277 1168290003630 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1168290003631 substrate binding site [chemical binding]; other site 1168290003632 ligand binding site [chemical binding]; other site 1168290003633 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1168290003634 substrate binding site [chemical binding]; other site 1168290003635 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1168290003636 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168290003637 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1168290003638 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1168290003639 Protein of unknown function (DUF418); Region: DUF418; cl12135 1168290003640 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1168290003641 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1168290003642 TRAM domain; Region: TRAM; cl01282 1168290003643 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1168290003644 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1168290003645 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1168290003646 putative active site [active] 1168290003647 putative catalytic site [active] 1168290003648 putative DNA binding site [nucleotide binding]; other site 1168290003649 putative phosphate binding site [ion binding]; other site 1168290003650 metal binding site A [ion binding]; metal-binding site 1168290003651 putative AP binding site [nucleotide binding]; other site 1168290003652 putative metal binding site B [ion binding]; other site 1168290003653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168290003654 AAA domain; Region: AAA_21; pfam13304 1168290003655 Walker A/P-loop; other site 1168290003656 ATP binding site [chemical binding]; other site 1168290003657 Q-loop/lid; other site 1168290003658 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168290003659 ABC transporter signature motif; other site 1168290003660 Walker B; other site 1168290003661 D-loop; other site 1168290003662 H-loop/switch region; other site 1168290003663 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168290003664 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168290003665 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1168290003666 Walker A/P-loop; other site 1168290003667 ATP binding site [chemical binding]; other site 1168290003668 Q-loop/lid; other site 1168290003669 ABC transporter signature motif; other site 1168290003670 Walker B; other site 1168290003671 D-loop; other site 1168290003672 H-loop/switch region; other site 1168290003673 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1168290003674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290003675 dimer interface [polypeptide binding]; other site 1168290003676 conserved gate region; other site 1168290003677 putative PBP binding loops; other site 1168290003678 ABC-ATPase subunit interface; other site 1168290003679 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168290003680 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290003681 dimer interface [polypeptide binding]; other site 1168290003682 conserved gate region; other site 1168290003683 putative PBP binding loops; other site 1168290003684 ABC-ATPase subunit interface; other site 1168290003685 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1168290003686 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1168290003687 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1168290003688 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168290003689 active site 1168290003690 DNA binding site [nucleotide binding] 1168290003691 Int/Topo IB signature motif; other site 1168290003692 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168290003693 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1168290003694 Walker A/P-loop; other site 1168290003695 ATP binding site [chemical binding]; other site 1168290003696 Q-loop/lid; other site 1168290003697 ABC transporter signature motif; other site 1168290003698 Walker B; other site 1168290003699 D-loop; other site 1168290003700 H-loop/switch region; other site 1168290003701 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1168290003702 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1168290003703 FtsX-like permease family; Region: FtsX; pfam02687 1168290003704 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1168290003705 FtsX-like permease family; Region: FtsX; pfam02687 1168290003706 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1168290003707 prephenate dehydrogenase; Validated; Region: PRK08507 1168290003708 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1168290003709 Prephenate dehydratase; Region: PDT; pfam00800 1168290003710 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1168290003711 putative L-Phe binding site [chemical binding]; other site 1168290003712 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1168290003713 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1168290003714 G1 box; other site 1168290003715 putative GEF interaction site [polypeptide binding]; other site 1168290003716 GTP/Mg2+ binding site [chemical binding]; other site 1168290003717 Switch I region; other site 1168290003718 G2 box; other site 1168290003719 G3 box; other site 1168290003720 Switch II region; other site 1168290003721 G4 box; other site 1168290003722 G5 box; other site 1168290003723 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1168290003724 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1168290003725 benzoate transport; Region: 2A0115; TIGR00895 1168290003726 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290003727 putative substrate translocation pore; other site 1168290003728 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1168290003729 nudix motif; other site 1168290003730 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1168290003731 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1168290003732 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168290003733 P-loop; other site 1168290003734 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1168290003735 Magnesium ion binding site [ion binding]; other site 1168290003736 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168290003737 Magnesium ion binding site [ion binding]; other site 1168290003738 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1168290003739 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1168290003740 active site 1168290003741 Int/Topo IB signature motif; other site 1168290003742 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1168290003743 23S rRNA binding site [nucleotide binding]; other site 1168290003744 L21 binding site [polypeptide binding]; other site 1168290003745 L13 binding site [polypeptide binding]; other site 1168290003746 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1168290003747 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1168290003748 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1168290003749 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1168290003750 Thiamine pyrophosphokinase; Region: TPK; cd07995 1168290003751 active site 1168290003752 dimerization interface [polypeptide binding]; other site 1168290003753 thiamine binding site [chemical binding]; other site 1168290003754 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1168290003755 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1168290003756 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1168290003757 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1168290003758 putative deacylase active site [active] 1168290003759 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1168290003760 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1168290003761 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1168290003762 active site 1168290003763 catalytic residues [active] 1168290003764 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1168290003765 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1168290003766 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1168290003767 DNA binding residues [nucleotide binding] 1168290003768 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1168290003769 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1168290003770 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168290003771 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168290003772 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1168290003773 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1168290003774 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1168290003775 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168290003776 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168290003777 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1168290003778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1168290003779 active site 1168290003780 phosphorylation site [posttranslational modification] 1168290003781 intermolecular recognition site; other site 1168290003782 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1168290003783 DNA binding residues [nucleotide binding] 1168290003784 dimerization interface [polypeptide binding]; other site 1168290003785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1168290003786 Histidine kinase; Region: HisKA_3; pfam07730 1168290003787 proline aminopeptidase P II; Provisional; Region: PRK10879 1168290003788 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1168290003789 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1168290003790 active site 1168290003791 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1168290003792 nudix motif; other site 1168290003793 MarR family; Region: MarR_2; cl17246 1168290003794 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168290003795 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1168290003796 nucleotide binding site [chemical binding]; other site 1168290003797 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1168290003798 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1168290003799 putative substrate binding site [chemical binding]; other site 1168290003800 putative ATP binding site [chemical binding]; other site 1168290003801 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1168290003802 putative active site [active] 1168290003803 dimerization interface [polypeptide binding]; other site 1168290003804 putative tRNAtyr binding site [nucleotide binding]; other site 1168290003805 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168290003806 active site 1168290003807 DNA binding site [nucleotide binding] 1168290003808 Int/Topo IB signature motif; other site 1168290003809 Helix-turn-helix domain; Region: HTH_17; pfam12728 1168290003810 Helix-turn-helix domain; Region: HTH_17; pfam12728 1168290003811 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1168290003812 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1168290003813 Walker A motif; other site 1168290003814 ATP binding site [chemical binding]; other site 1168290003815 Walker B motif; other site 1168290003816 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1168290003817 Phage capsid family; Region: Phage_capsid; pfam05065 1168290003818 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1168290003819 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168290003820 Walker A/P-loop; other site 1168290003821 ATP binding site [chemical binding]; other site 1168290003822 Q-loop/lid; other site 1168290003823 ABC transporter signature motif; other site 1168290003824 Walker B; other site 1168290003825 D-loop; other site 1168290003826 H-loop/switch region; other site 1168290003827 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168290003828 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1168290003829 Walker A/P-loop; other site 1168290003830 ATP binding site [chemical binding]; other site 1168290003831 Q-loop/lid; other site 1168290003832 ABC transporter signature motif; other site 1168290003833 Walker B; other site 1168290003834 D-loop; other site 1168290003835 H-loop/switch region; other site 1168290003836 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168290003837 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1168290003838 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1168290003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290003840 dimer interface [polypeptide binding]; other site 1168290003841 conserved gate region; other site 1168290003842 ABC-ATPase subunit interface; other site 1168290003843 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1168290003844 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290003845 dimer interface [polypeptide binding]; other site 1168290003846 conserved gate region; other site 1168290003847 putative PBP binding loops; other site 1168290003848 ABC-ATPase subunit interface; other site 1168290003849 potential frameshift: common BLAST hit: gi|311063978|ref|YP_003970703.1| peptide ABC transporter substrate-binding protein OppA 1168290003850 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168290003851 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1168290003852 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168290003853 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1168290003854 cell division protein FtsQ; Provisional; Region: PRK05529 1168290003855 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1168290003856 Cell division protein FtsQ; Region: FtsQ; pfam03799 1168290003857 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1168290003858 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1168290003859 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168290003860 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168290003861 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1168290003862 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1168290003863 active site 1168290003864 homodimer interface [polypeptide binding]; other site 1168290003865 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1168290003866 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1168290003867 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1168290003868 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168290003869 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168290003870 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1168290003871 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1168290003872 Mg++ binding site [ion binding]; other site 1168290003873 putative catalytic motif [active] 1168290003874 putative substrate binding site [chemical binding]; other site 1168290003875 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1168290003876 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1168290003877 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1168290003878 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1168290003879 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 1168290003880 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1168290003881 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1168290003882 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1168290003883 MraW methylase family; Region: Methyltransf_5; cl17771 1168290003884 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1168290003885 MraZ protein; Region: MraZ; pfam02381 1168290003886 cell division protein MraZ; Reviewed; Region: PRK00326 1168290003887 MraZ protein; Region: MraZ; pfam02381 1168290003888 Part of AAA domain; Region: AAA_19; pfam13245 1168290003889 Family description; Region: UvrD_C_2; pfam13538 1168290003890 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1168290003891 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1168290003892 ligand binding site [chemical binding]; other site 1168290003893 NAD binding site [chemical binding]; other site 1168290003894 tetramer interface [polypeptide binding]; other site 1168290003895 catalytic site [active] 1168290003896 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1168290003897 L-serine binding site [chemical binding]; other site 1168290003898 ACT domain interface; other site 1168290003899 transcriptional regulator NrdR; Region: TIGR00244 1168290003900 ATP cone domain; Region: ATP-cone; pfam03477 1168290003901 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1168290003902 LexA repressor; Validated; Region: PRK00215 1168290003903 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1168290003904 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1168290003905 Catalytic site [active] 1168290003906 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1168290003907 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1168290003908 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1168290003909 NAD binding site [chemical binding]; other site 1168290003910 dimer interface [polypeptide binding]; other site 1168290003911 substrate binding site [chemical binding]; other site 1168290003912 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168290003913 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1168290003914 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1168290003915 HflX GTPase family; Region: HflX; cd01878 1168290003916 G1 box; other site 1168290003917 GTP/Mg2+ binding site [chemical binding]; other site 1168290003918 Switch I region; other site 1168290003919 G2 box; other site 1168290003920 G3 box; other site 1168290003921 Switch II region; other site 1168290003922 G4 box; other site 1168290003923 G5 box; other site 1168290003924 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1168290003925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1168290003926 S-adenosylmethionine binding site [chemical binding]; other site 1168290003927 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1168290003928 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1168290003929 ATP binding site [chemical binding]; other site 1168290003930 putative Mg++ binding site [ion binding]; other site 1168290003931 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1168290003932 nucleotide binding region [chemical binding]; other site 1168290003933 ATP-binding site [chemical binding]; other site 1168290003934 Helicase associated domain (HA2); Region: HA2; pfam04408 1168290003935 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1168290003936 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1168290003937 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1168290003938 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1168290003939 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1168290003940 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1168290003941 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1168290003942 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1168290003943 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1168290003944 catalytic residues [active] 1168290003945 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1168290003946 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1168290003947 putative active site [active] 1168290003948 oxyanion strand; other site 1168290003949 catalytic triad [active] 1168290003950 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1168290003951 putative active site pocket [active] 1168290003952 4-fold oligomerization interface [polypeptide binding]; other site 1168290003953 metal binding residues [ion binding]; metal-binding site 1168290003954 3-fold/trimer interface [polypeptide binding]; other site 1168290003955 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1168290003956 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290003957 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290003958 homodimer interface [polypeptide binding]; other site 1168290003959 catalytic residue [active] 1168290003960 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1168290003961 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1168290003962 NAD binding site [chemical binding]; other site 1168290003963 dimerization interface [polypeptide binding]; other site 1168290003964 product binding site; other site 1168290003965 substrate binding site [chemical binding]; other site 1168290003966 zinc binding site [ion binding]; other site 1168290003967 catalytic residues [active] 1168290003968 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1168290003969 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1168290003970 active site 1168290003971 PHP Thumb interface [polypeptide binding]; other site 1168290003972 metal binding site [ion binding]; metal-binding site 1168290003973 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1168290003974 generic binding surface I; other site 1168290003975 generic binding surface II; other site 1168290003976 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1168290003977 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1168290003978 RNA binding surface [nucleotide binding]; other site 1168290003979 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1168290003980 active site 1168290003981 lipoprotein signal peptidase; Provisional; Region: PRK14771 1168290003982 DivIVA protein; Region: DivIVA; pfam05103 1168290003983 DivIVA domain; Region: DivI1A_domain; TIGR03544 1168290003984 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1168290003985 YGGT family; Region: YGGT; pfam02325 1168290003986 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1168290003987 cell division protein FtsZ; Validated; Region: PRK09330 1168290003988 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1168290003989 nucleotide binding site [chemical binding]; other site 1168290003990 SulA interaction site; other site 1168290003991 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1168290003992 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1168290003993 FMN binding site [chemical binding]; other site 1168290003994 active site 1168290003995 catalytic residues [active] 1168290003996 substrate binding site [chemical binding]; other site 1168290003997 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1168290003998 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1168290003999 motif 1; other site 1168290004000 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1168290004001 active site 1168290004002 motif 2; other site 1168290004003 motif 3; other site 1168290004004 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1168290004005 anticodon binding site; other site 1168290004006 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1168290004007 substrate binding site [chemical binding]; other site 1168290004008 multimerization interface [polypeptide binding]; other site 1168290004009 ATP binding site [chemical binding]; other site 1168290004010 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1168290004011 thiamine phosphate binding site [chemical binding]; other site 1168290004012 active site 1168290004013 pyrophosphate binding site [ion binding]; other site 1168290004014 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1168290004015 substrate binding site [chemical binding]; other site 1168290004016 dimer interface [polypeptide binding]; other site 1168290004017 ATP binding site [chemical binding]; other site 1168290004018 Domain of unknown function DUF77; Region: DUF77; pfam01910 1168290004019 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290004020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290004021 DNA binding site [nucleotide binding] 1168290004022 domain linker motif; other site 1168290004023 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1168290004024 putative dimerization interface [polypeptide binding]; other site 1168290004025 putative ligand binding site [chemical binding]; other site 1168290004026 galactoside permease; Reviewed; Region: lacY; PRK09528 1168290004027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290004028 putative substrate translocation pore; other site 1168290004029 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1168290004030 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1168290004031 substrate binding [chemical binding]; other site 1168290004032 active site 1168290004033 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1168290004034 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1168290004035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290004036 dimer interface [polypeptide binding]; other site 1168290004037 conserved gate region; other site 1168290004038 putative PBP binding loops; other site 1168290004039 ABC-ATPase subunit interface; other site 1168290004040 NMT1/THI5 like; Region: NMT1; pfam09084 1168290004041 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1168290004042 active site 1168290004043 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 1168290004044 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1168290004045 catalytic residue [active] 1168290004046 putative FPP diphosphate binding site; other site 1168290004047 putative FPP binding hydrophobic cleft; other site 1168290004048 dimer interface [polypeptide binding]; other site 1168290004049 putative IPP diphosphate binding site; other site 1168290004050 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1168290004051 Recombination protein O N terminal; Region: RecO_N; pfam11967 1168290004052 Recombination protein O C terminal; Region: RecO_C; pfam02565 1168290004053 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168290004054 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1168290004055 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1168290004056 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1168290004057 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1168290004058 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1168290004059 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1168290004060 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1168290004061 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1168290004062 DivIVA domain; Region: DivI1A_domain; TIGR03544 1168290004063 DivIVA domain; Region: DivI1A_domain; TIGR03544 1168290004064 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1168290004065 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1168290004066 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1168290004067 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1168290004068 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1168290004069 Part of AAA domain; Region: AAA_19; pfam13245 1168290004070 Family description; Region: UvrD_C_2; pfam13538 1168290004071 Phosphotransferase enzyme family; Region: APH; pfam01636 1168290004072 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1168290004073 substrate binding site [chemical binding]; other site 1168290004074 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1168290004075 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1168290004076 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1168290004077 active site 1168290004078 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1168290004079 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1168290004080 putative active site [active] 1168290004081 redox center [active] 1168290004082 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1168290004083 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1168290004084 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1168290004085 glutamate racemase; Provisional; Region: PRK00865 1168290004086 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1168290004087 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1168290004088 active site 1168290004089 nucleophile elbow; other site 1168290004090 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1168290004091 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1168290004092 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1168290004093 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1168290004094 substrate binding pocket [chemical binding]; other site 1168290004095 membrane-bound complex binding site; other site 1168290004096 hinge residues; other site 1168290004097 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1168290004098 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290004099 Walker A/P-loop; other site 1168290004100 ATP binding site [chemical binding]; other site 1168290004101 Q-loop/lid; other site 1168290004102 ABC transporter signature motif; other site 1168290004103 Walker B; other site 1168290004104 D-loop; other site 1168290004105 H-loop/switch region; other site 1168290004106 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1168290004107 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290004108 dimer interface [polypeptide binding]; other site 1168290004109 conserved gate region; other site 1168290004110 putative PBP binding loops; other site 1168290004111 ABC-ATPase subunit interface; other site 1168290004112 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1168290004113 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290004114 dimer interface [polypeptide binding]; other site 1168290004115 conserved gate region; other site 1168290004116 putative PBP binding loops; other site 1168290004117 ABC-ATPase subunit interface; other site 1168290004118 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1168290004119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290004120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290004121 homodimer interface [polypeptide binding]; other site 1168290004122 catalytic residue [active] 1168290004123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290004124 putative PBP binding loops; other site 1168290004125 ABC-ATPase subunit interface; other site 1168290004126 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1168290004127 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1168290004128 Walker A/P-loop; other site 1168290004129 ATP binding site [chemical binding]; other site 1168290004130 Q-loop/lid; other site 1168290004131 ABC transporter signature motif; other site 1168290004132 Walker B; other site 1168290004133 D-loop; other site 1168290004134 H-loop/switch region; other site 1168290004135 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1168290004136 NIL domain; Region: NIL; pfam09383 1168290004137 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1168290004138 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1168290004139 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1168290004140 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1168290004141 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1168290004142 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1168290004143 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1168290004144 active site 1168290004145 catalytic site [active] 1168290004146 substrate binding site [chemical binding]; other site 1168290004147 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1168290004148 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1168290004149 G1 box; other site 1168290004150 putative GEF interaction site [polypeptide binding]; other site 1168290004151 GTP/Mg2+ binding site [chemical binding]; other site 1168290004152 Switch I region; other site 1168290004153 G2 box; other site 1168290004154 G3 box; other site 1168290004155 Switch II region; other site 1168290004156 G4 box; other site 1168290004157 G5 box; other site 1168290004158 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1168290004159 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1168290004160 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1168290004161 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1168290004162 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1168290004163 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1168290004164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290004165 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290004166 putative substrate translocation pore; other site 1168290004167 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1168290004168 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1168290004169 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1168290004170 HIGH motif; other site 1168290004171 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1168290004172 active site 1168290004173 KMSKS motif; other site 1168290004174 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1168290004175 tRNA binding surface [nucleotide binding]; other site 1168290004176 anticodon binding site; other site 1168290004177 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1168290004178 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1168290004179 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168290004180 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168290004181 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1168290004182 Walker A/P-loop; other site 1168290004183 ATP binding site [chemical binding]; other site 1168290004184 Q-loop/lid; other site 1168290004185 ABC transporter signature motif; other site 1168290004186 Walker B; other site 1168290004187 D-loop; other site 1168290004188 H-loop/switch region; other site 1168290004189 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168290004190 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168290004191 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290004192 Walker A/P-loop; other site 1168290004193 ATP binding site [chemical binding]; other site 1168290004194 Q-loop/lid; other site 1168290004195 ABC transporter signature motif; other site 1168290004196 Walker B; other site 1168290004197 D-loop; other site 1168290004198 H-loop/switch region; other site 1168290004199 MarR family; Region: MarR_2; pfam12802 1168290004200 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1168290004201 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1168290004202 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1168290004203 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1168290004204 mismatch recognition site; other site 1168290004205 additional DNA contacts [nucleotide binding]; other site 1168290004206 active site 1168290004207 zinc binding site [ion binding]; other site 1168290004208 DNA intercalation site [nucleotide binding]; other site 1168290004209 Fic/DOC family; Region: Fic; cl00960 1168290004210 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 1168290004211 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1168290004212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1168290004213 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 1168290004214 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1168290004215 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1168290004216 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1168290004217 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1168290004218 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1168290004219 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1168290004220 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1168290004221 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1168290004222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1168290004223 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1168290004224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1168290004225 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1168290004226 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1168290004227 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1168290004228 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1168290004229 FeS/SAM binding site; other site 1168290004230 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1168290004231 ATP cone domain; Region: ATP-cone; pfam03477 1168290004232 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1168290004233 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1168290004234 active site 1168290004235 Zn binding site [ion binding]; other site 1168290004236 glycine loop; other site 1168290004237 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1168290004238 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1168290004239 generic binding surface II; other site 1168290004240 generic binding surface I; other site 1168290004241 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1168290004242 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1168290004243 putative catalytic site [active] 1168290004244 putative metal binding site [ion binding]; other site 1168290004245 putative phosphate binding site [ion binding]; other site 1168290004246 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 1168290004247 aminotransferase; Validated; Region: PRK07337 1168290004248 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1168290004249 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290004250 homodimer interface [polypeptide binding]; other site 1168290004251 catalytic residue [active] 1168290004252 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1168290004253 additional DNA contacts [nucleotide binding]; other site 1168290004254 mismatch recognition site; other site 1168290004255 active site 1168290004256 zinc binding site [ion binding]; other site 1168290004257 DNA intercalation site [nucleotide binding]; other site 1168290004258 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1168290004259 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1168290004260 active site 1168290004261 catalytic site [active] 1168290004262 substrate binding site [chemical binding]; other site 1168290004263 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1168290004264 active site 1168290004265 catalytic residues [active] 1168290004266 metal binding site [ion binding]; metal-binding site 1168290004267 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1168290004268 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1168290004269 active site 1168290004270 substrate binding site [chemical binding]; other site 1168290004271 metal binding site [ion binding]; metal-binding site 1168290004272 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1168290004273 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1168290004274 Zn binding site [ion binding]; other site 1168290004275 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1168290004276 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1168290004277 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1168290004278 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1168290004279 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1168290004280 dimer interface [polypeptide binding]; other site 1168290004281 active site 1168290004282 catalytic residue [active] 1168290004283 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1168290004284 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1168290004285 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1168290004286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290004287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290004288 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1168290004289 Coenzyme A binding pocket [chemical binding]; other site 1168290004290 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1168290004291 Family description; Region: UvrD_C_2; pfam13538 1168290004292 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1168290004293 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1168290004294 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168290004295 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168290004296 active site 1168290004297 ATP binding site [chemical binding]; other site 1168290004298 substrate binding site [chemical binding]; other site 1168290004299 activation loop (A-loop); other site 1168290004300 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1168290004301 Interdomain contacts; other site 1168290004302 Cytokine receptor motif; other site 1168290004303 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1168290004304 Interdomain contacts; other site 1168290004305 Cytokine receptor motif; other site 1168290004306 MoxR-like ATPases [General function prediction only]; Region: COG0714 1168290004307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290004308 Walker A motif; other site 1168290004309 ATP binding site [chemical binding]; other site 1168290004310 Walker B motif; other site 1168290004311 arginine finger; other site 1168290004312 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1168290004313 Protein of unknown function DUF58; Region: DUF58; pfam01882 1168290004314 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1168290004315 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1168290004316 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1168290004317 phosphopeptide binding site; other site 1168290004318 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1168290004319 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1168290004320 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1168290004321 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1168290004322 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1168290004323 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1168290004324 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1168290004325 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1168290004326 DNA binding site [nucleotide binding] 1168290004327 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1168290004328 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1168290004329 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1168290004330 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1168290004331 RPB1 interaction site [polypeptide binding]; other site 1168290004332 RPB10 interaction site [polypeptide binding]; other site 1168290004333 RPB11 interaction site [polypeptide binding]; other site 1168290004334 RPB3 interaction site [polypeptide binding]; other site 1168290004335 RPB12 interaction site [polypeptide binding]; other site 1168290004336 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1168290004337 endonuclease III; Region: ENDO3c; smart00478 1168290004338 minor groove reading motif; other site 1168290004339 helix-hairpin-helix signature motif; other site 1168290004340 substrate binding pocket [chemical binding]; other site 1168290004341 active site 1168290004342 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1168290004343 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1168290004344 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1168290004345 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1168290004346 active site 1168290004347 catalytic site [active] 1168290004348 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1168290004349 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1168290004350 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1168290004351 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1168290004352 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1168290004353 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1168290004354 dimer interface [polypeptide binding]; other site 1168290004355 active site 1168290004356 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1168290004357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1168290004358 DNA-binding site [nucleotide binding]; DNA binding site 1168290004359 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1168290004360 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1168290004361 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1168290004362 Ligand binding site; other site 1168290004363 Putative Catalytic site; other site 1168290004364 DXD motif; other site 1168290004365 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1168290004366 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1168290004367 quinone interaction residues [chemical binding]; other site 1168290004368 active site 1168290004369 catalytic residues [active] 1168290004370 FMN binding site [chemical binding]; other site 1168290004371 substrate binding site [chemical binding]; other site 1168290004372 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1168290004373 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1168290004374 active site 1168290004375 FMN binding site [chemical binding]; other site 1168290004376 substrate binding site [chemical binding]; other site 1168290004377 homotetramer interface [polypeptide binding]; other site 1168290004378 catalytic residue [active] 1168290004379 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1168290004380 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1168290004381 ligand binding site [chemical binding]; other site 1168290004382 flexible hinge region; other site 1168290004383 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1168290004384 putative switch regulator; other site 1168290004385 non-specific DNA interactions [nucleotide binding]; other site 1168290004386 DNA binding site [nucleotide binding] 1168290004387 sequence specific DNA binding site [nucleotide binding]; other site 1168290004388 putative cAMP binding site [chemical binding]; other site 1168290004389 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1168290004390 TM2 domain; Region: TM2; pfam05154 1168290004391 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1168290004392 tartrate dehydrogenase; Region: TTC; TIGR02089 1168290004393 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1168290004394 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168290004395 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1168290004396 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1168290004397 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1168290004398 lipoyl attachment site [posttranslational modification]; other site 1168290004399 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1168290004400 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1168290004401 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1168290004402 putative NADH binding site [chemical binding]; other site 1168290004403 putative active site [active] 1168290004404 nudix motif; other site 1168290004405 putative metal binding site [ion binding]; other site 1168290004406 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168290004407 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1168290004408 nudix motif; other site 1168290004409 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1168290004410 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1168290004411 catalytic residues [active] 1168290004412 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1168290004413 G5 domain; Region: G5; pfam07501 1168290004414 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1168290004415 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1168290004416 catalytic residue [active] 1168290004417 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1168290004418 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1168290004419 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1168290004420 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1168290004421 Putative Catalytic site; other site 1168290004422 DXD motif; other site 1168290004423 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1168290004424 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1168290004425 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1168290004426 substrate binding site; other site 1168290004427 tetramer interface; other site 1168290004428 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1168290004429 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1168290004430 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1168290004431 NADP binding site [chemical binding]; other site 1168290004432 active site 1168290004433 putative substrate binding site [chemical binding]; other site 1168290004434 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1168290004435 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1168290004436 NAD binding site [chemical binding]; other site 1168290004437 substrate binding site [chemical binding]; other site 1168290004438 homodimer interface [polypeptide binding]; other site 1168290004439 active site 1168290004440 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1168290004441 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1168290004442 Probable Catalytic site; other site 1168290004443 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1168290004444 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1168290004445 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1168290004446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168290004447 active site 1168290004448 putative glycosyl transferase; Provisional; Region: PRK10073 1168290004449 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1168290004450 active site 1168290004451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168290004452 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1168290004453 active site 1168290004454 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1168290004455 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1168290004456 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1168290004457 active site 1168290004458 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1168290004459 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1168290004460 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1168290004461 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1168290004462 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1168290004463 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1168290004464 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1168290004465 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1168290004466 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1168290004467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290004468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290004469 putative substrate translocation pore; other site 1168290004470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290004471 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1168290004472 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1168290004473 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1168290004474 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1168290004475 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1168290004476 active site 1168290004477 multimer interface [polypeptide binding]; other site 1168290004478 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1168290004479 predicted active site [active] 1168290004480 catalytic triad [active] 1168290004481 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1168290004482 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1168290004483 putative NAD(P) binding site [chemical binding]; other site 1168290004484 active site 1168290004485 putative substrate binding site [chemical binding]; other site 1168290004486 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1168290004487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168290004488 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1168290004489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290004490 Walker A/P-loop; other site 1168290004491 ATP binding site [chemical binding]; other site 1168290004492 Q-loop/lid; other site 1168290004493 ABC transporter signature motif; other site 1168290004494 Walker B; other site 1168290004495 D-loop; other site 1168290004496 H-loop/switch region; other site 1168290004497 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168290004498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290004499 Walker A/P-loop; other site 1168290004500 ATP binding site [chemical binding]; other site 1168290004501 Q-loop/lid; other site 1168290004502 ABC transporter signature motif; other site 1168290004503 Walker B; other site 1168290004504 D-loop; other site 1168290004505 H-loop/switch region; other site 1168290004506 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1168290004507 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1168290004508 acyl-activating enzyme (AAE) consensus motif; other site 1168290004509 putative AMP binding site [chemical binding]; other site 1168290004510 putative active site [active] 1168290004511 putative CoA binding site [chemical binding]; other site 1168290004512 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1168290004513 putative active site [active] 1168290004514 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1168290004515 dimer interface [polypeptide binding]; other site 1168290004516 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1168290004517 nudix motif; other site 1168290004518 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1168290004519 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1168290004520 active site 1168290004521 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1168290004522 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1168290004523 Chain length determinant protein; Region: Wzz; cl15801 1168290004524 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1168290004525 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1168290004526 Nucleotide binding site [chemical binding]; other site 1168290004527 DTAP/Switch II; other site 1168290004528 Switch I; other site 1168290004529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1168290004530 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1168290004531 homoserine kinase; Provisional; Region: PRK01212 1168290004532 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1168290004533 homoserine dehydrogenase; Provisional; Region: PRK06349 1168290004534 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1168290004535 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1168290004536 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1168290004537 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1168290004538 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1168290004539 catalytic residue [active] 1168290004540 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1168290004541 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168290004542 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1168290004543 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1168290004544 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1168290004545 active site 1168290004546 HIGH motif; other site 1168290004547 KMSK motif region; other site 1168290004548 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1168290004549 tRNA binding surface [nucleotide binding]; other site 1168290004550 anticodon binding site; other site 1168290004551 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1168290004552 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1168290004553 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1168290004554 homotrimer interaction site [polypeptide binding]; other site 1168290004555 putative active site [active] 1168290004556 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168290004557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290004558 dimer interface [polypeptide binding]; other site 1168290004559 conserved gate region; other site 1168290004560 putative PBP binding loops; other site 1168290004561 ABC-ATPase subunit interface; other site 1168290004562 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1168290004563 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1168290004564 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1168290004565 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1168290004566 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1168290004567 hypothetical protein; Provisional; Region: PRK03298 1168290004568 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1168290004569 gamma subunit interface [polypeptide binding]; other site 1168290004570 epsilon subunit interface [polypeptide binding]; other site 1168290004571 LBP interface [polypeptide binding]; other site 1168290004572 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1168290004573 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1168290004574 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1168290004575 alpha subunit interaction interface [polypeptide binding]; other site 1168290004576 Walker A motif; other site 1168290004577 ATP binding site [chemical binding]; other site 1168290004578 Walker B motif; other site 1168290004579 inhibitor binding site; inhibition site 1168290004580 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1168290004581 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1168290004582 core domain interface [polypeptide binding]; other site 1168290004583 delta subunit interface [polypeptide binding]; other site 1168290004584 epsilon subunit interface [polypeptide binding]; other site 1168290004585 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1168290004586 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1168290004587 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1168290004588 beta subunit interaction interface [polypeptide binding]; other site 1168290004589 Walker A motif; other site 1168290004590 ATP binding site [chemical binding]; other site 1168290004591 Walker B motif; other site 1168290004592 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1168290004593 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1168290004594 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1168290004595 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1168290004596 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1168290004597 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1168290004598 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1168290004599 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1168290004600 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1168290004601 proposed active site lysine [active] 1168290004602 conserved cys residue [active] 1168290004603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290004604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290004605 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1168290004606 active site 1168290004607 tetramer interface [polypeptide binding]; other site 1168290004608 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1168290004609 Plasmid replication protein; Region: Rep_2; pfam01719 1168290004610 Protein of unknown function DUF262; Region: DUF262; pfam03235 1168290004611 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1168290004612 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1168290004613 active site 1168290004614 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 1168290004615 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1168290004616 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1168290004617 Int/Topo IB signature motif; other site 1168290004618 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1168290004619 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1168290004620 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1168290004621 Cellulose or protein binding domain; Region: CBM_10; pfam02013 1168290004622 Membrane transport protein; Region: Mem_trans; cl09117 1168290004623 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1168290004624 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1168290004625 PYR/PP interface [polypeptide binding]; other site 1168290004626 dimer interface [polypeptide binding]; other site 1168290004627 TPP binding site [chemical binding]; other site 1168290004628 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1168290004629 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1168290004630 TPP-binding site; other site 1168290004631 dimer interface [polypeptide binding]; other site 1168290004632 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1168290004633 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1168290004634 Cl- selectivity filter; other site 1168290004635 Cl- binding residues [ion binding]; other site 1168290004636 pore gating glutamate residue; other site 1168290004637 dimer interface [polypeptide binding]; other site 1168290004638 TQXA domain; Region: TQXA_dom; TIGR03934 1168290004639 Cna protein B-type domain; Region: Cna_B; pfam05738 1168290004640 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1168290004641 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1168290004642 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1168290004643 active site 1168290004644 catalytic site [active] 1168290004645 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1168290004646 dimer interface [polypeptide binding]; other site 1168290004647 substrate binding site [chemical binding]; other site 1168290004648 metal binding sites [ion binding]; metal-binding site 1168290004649 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1168290004650 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1168290004651 DNA binding site [nucleotide binding] 1168290004652 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1168290004653 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1168290004654 minor groove reading motif; other site 1168290004655 helix-hairpin-helix signature motif; other site 1168290004656 substrate binding pocket [chemical binding]; other site 1168290004657 active site 1168290004658 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1168290004659 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1168290004660 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1168290004661 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1168290004662 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168290004663 active site 1168290004664 HIGH motif; other site 1168290004665 nucleotide binding site [chemical binding]; other site 1168290004666 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1168290004667 active site 1168290004668 KMSKS motif; other site 1168290004669 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1168290004670 tRNA binding surface [nucleotide binding]; other site 1168290004671 anticodon binding site; other site 1168290004672 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1168290004673 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1168290004674 dimerization interface [polypeptide binding]; other site 1168290004675 putative Zn2+ binding site [ion binding]; other site 1168290004676 putative DNA binding site [nucleotide binding]; other site 1168290004677 chorismate mutase; Provisional; Region: PRK09239 1168290004678 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1168290004679 transcription termination factor Rho; Provisional; Region: PRK12608 1168290004680 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1168290004681 RNA binding site [nucleotide binding]; other site 1168290004682 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1168290004683 Walker A motif; other site 1168290004684 ATP binding site [chemical binding]; other site 1168290004685 Walker B motif; other site 1168290004686 hypothetical protein; Provisional; Region: PRK07208 1168290004687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168290004688 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1168290004689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1168290004690 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1168290004691 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1168290004692 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1168290004693 GatB domain; Region: GatB_Yqey; pfam02637 1168290004694 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1168290004695 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1168290004696 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1168290004697 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290004698 ABC transporter signature motif; other site 1168290004699 Walker B; other site 1168290004700 D-loop; other site 1168290004701 H-loop/switch region; other site 1168290004702 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1168290004703 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1168290004704 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1168290004705 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168290004706 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1168290004707 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1168290004708 Clp amino terminal domain; Region: Clp_N; pfam02861 1168290004709 Clp amino terminal domain; Region: Clp_N; pfam02861 1168290004710 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290004711 Walker A motif; other site 1168290004712 ATP binding site [chemical binding]; other site 1168290004713 Walker B motif; other site 1168290004714 arginine finger; other site 1168290004715 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1168290004716 Walker A motif; other site 1168290004717 ATP binding site [chemical binding]; other site 1168290004718 Walker B motif; other site 1168290004719 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1168290004720 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1168290004721 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1168290004722 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1168290004723 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1168290004724 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1168290004725 metal ion-dependent adhesion site (MIDAS); other site 1168290004726 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1168290004727 active site 1168290004728 catalytic site [active] 1168290004729 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1168290004730 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1168290004731 catalytic residue [active] 1168290004732 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1168290004733 active site 1168290004734 HIGH motif; other site 1168290004735 nucleotide binding site [chemical binding]; other site 1168290004736 active site 1168290004737 KMSKS motif; other site 1168290004738 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1168290004739 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1168290004740 amphipathic channel; other site 1168290004741 Asn-Pro-Ala signature motifs; other site 1168290004742 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1168290004743 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1168290004744 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1168290004745 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1168290004746 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1168290004747 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1168290004748 dimer interface [polypeptide binding]; other site 1168290004749 ssDNA binding site [nucleotide binding]; other site 1168290004750 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1168290004751 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1168290004752 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1168290004753 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1168290004754 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1168290004755 active site 1168290004756 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1168290004757 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1168290004758 substrate binding site [chemical binding]; other site 1168290004759 dimer interface [polypeptide binding]; other site 1168290004760 ATP binding site [chemical binding]; other site 1168290004761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1168290004762 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1168290004763 putative substrate translocation pore; other site 1168290004764 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1168290004765 active site 1168290004766 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290004767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290004768 DNA binding site [nucleotide binding] 1168290004769 domain linker motif; other site 1168290004770 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1168290004771 dimerization interface [polypeptide binding]; other site 1168290004772 ligand binding site [chemical binding]; other site 1168290004773 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1168290004774 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1168290004775 UDP-galactopyranose mutase; Region: GLF; pfam03275 1168290004776 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168290004777 active site 1168290004778 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1168290004779 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168290004780 active site 1168290004781 Sulfatase; Region: Sulfatase; pfam00884 1168290004782 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1168290004783 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168290004784 active site 1168290004785 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1168290004786 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1168290004787 active site 1168290004788 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1168290004789 active site 1168290004790 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1168290004791 S-layer homology domain; Region: SLH; pfam00395 1168290004792 S-layer homology domain; Region: SLH; pfam00395 1168290004793 S-layer homology domain; Region: SLH; pfam00395 1168290004794 MULE transposase domain; Region: MULE; pfam10551 1168290004795 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1168290004796 Leucine rich repeat; Region: LRR_8; pfam13855 1168290004797 S-layer homology domain; Region: SLH; pfam00395 1168290004798 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1168290004799 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1168290004800 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1168290004801 Walker A/P-loop; other site 1168290004802 ATP binding site [chemical binding]; other site 1168290004803 Q-loop/lid; other site 1168290004804 ABC transporter signature motif; other site 1168290004805 Walker B; other site 1168290004806 D-loop; other site 1168290004807 H-loop/switch region; other site 1168290004808 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1168290004809 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1168290004810 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1168290004811 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1168290004812 active site 1168290004813 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1168290004814 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1168290004815 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1168290004816 FtsX-like permease family; Region: FtsX; pfam02687 1168290004817 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1168290004818 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290004819 ATP binding site [chemical binding]; other site 1168290004820 Q-loop/lid; other site 1168290004821 ABC transporter signature motif; other site 1168290004822 Walker B; other site 1168290004823 D-loop; other site 1168290004824 H-loop/switch region; other site 1168290004825 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168290004826 Zn2+ binding site [ion binding]; other site 1168290004827 Mg2+ binding site [ion binding]; other site 1168290004828 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1168290004829 putative active site [active] 1168290004830 putative dimer interface [polypeptide binding]; other site 1168290004831 YL1 nuclear protein; Region: YL1; pfam05764 1168290004832 K+ potassium transporter; Region: K_trans; pfam02705 1168290004833 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1168290004834 active site 1168290004835 Melibiase; Region: Melibiase; pfam02065 1168290004836 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168290004837 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168290004838 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1168290004839 Walker A/P-loop; other site 1168290004840 ATP binding site [chemical binding]; other site 1168290004841 Q-loop/lid; other site 1168290004842 ABC transporter signature motif; other site 1168290004843 Walker B; other site 1168290004844 D-loop; other site 1168290004845 H-loop/switch region; other site 1168290004846 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1168290004847 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1168290004848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1168290004849 Walker A/P-loop; other site 1168290004850 ATP binding site [chemical binding]; other site 1168290004851 Q-loop/lid; other site 1168290004852 ABC transporter signature motif; other site 1168290004853 Walker B; other site 1168290004854 D-loop; other site 1168290004855 H-loop/switch region; other site 1168290004856 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1168290004857 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1168290004858 active site 1168290004859 HIGH motif; other site 1168290004860 KMSKS motif; other site 1168290004861 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1168290004862 tRNA binding surface [nucleotide binding]; other site 1168290004863 anticodon binding site; other site 1168290004864 Predicted methyltransferases [General function prediction only]; Region: COG0313 1168290004865 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1168290004866 putative SAM binding site [chemical binding]; other site 1168290004867 putative homodimer interface [polypeptide binding]; other site 1168290004868 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1168290004869 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1168290004870 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1168290004871 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1168290004872 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1168290004873 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1168290004874 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1168290004875 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1168290004876 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1168290004877 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1168290004878 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1168290004879 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1168290004880 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1168290004881 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290004882 motif II; other site 1168290004883 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1168290004884 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1168290004885 DNA binding residues [nucleotide binding] 1168290004886 putative dimer interface [polypeptide binding]; other site 1168290004887 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1168290004888 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1168290004889 HSP70 interaction site [polypeptide binding]; other site 1168290004890 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1168290004891 substrate binding site [polypeptide binding]; other site 1168290004892 dimer interface [polypeptide binding]; other site 1168290004893 GrpE; Region: GrpE; pfam01025 1168290004894 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1168290004895 dimer interface [polypeptide binding]; other site 1168290004896 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1168290004897 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1168290004898 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1168290004899 nucleotide binding site [chemical binding]; other site 1168290004900 NEF interaction site [polypeptide binding]; other site 1168290004901 SBD interface [polypeptide binding]; other site 1168290004902 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290004903 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290004904 DNA binding site [nucleotide binding] 1168290004905 domain linker motif; other site 1168290004906 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1168290004907 ligand binding site [chemical binding]; other site 1168290004908 dimerization interface [polypeptide binding]; other site 1168290004909 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1168290004910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290004911 motif II; other site 1168290004912 pullulanase, type I; Region: pulA_typeI; TIGR02104 1168290004913 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1168290004914 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1168290004915 Ca binding site [ion binding]; other site 1168290004916 active site 1168290004917 catalytic site [active] 1168290004918 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168290004919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290004920 dimer interface [polypeptide binding]; other site 1168290004921 conserved gate region; other site 1168290004922 putative PBP binding loops; other site 1168290004923 ABC-ATPase subunit interface; other site 1168290004924 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1168290004925 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290004926 dimer interface [polypeptide binding]; other site 1168290004927 conserved gate region; other site 1168290004928 putative PBP binding loops; other site 1168290004929 ABC-ATPase subunit interface; other site 1168290004930 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1168290004931 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1168290004932 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1168290004933 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1168290004934 active site 1168290004935 catalytic site [active] 1168290004936 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1168290004937 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1168290004938 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1168290004939 Protein of unknown function, DUF624; Region: DUF624; cl02369 1168290004940 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168290004941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290004942 dimer interface [polypeptide binding]; other site 1168290004943 conserved gate region; other site 1168290004944 putative PBP binding loops; other site 1168290004945 ABC-ATPase subunit interface; other site 1168290004946 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168290004947 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290004948 dimer interface [polypeptide binding]; other site 1168290004949 conserved gate region; other site 1168290004950 putative PBP binding loops; other site 1168290004951 ABC-ATPase subunit interface; other site 1168290004952 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1168290004953 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1168290004954 DNA binding site [nucleotide binding] 1168290004955 domain linker motif; other site 1168290004956 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1168290004957 ligand binding site [chemical binding]; other site 1168290004958 dimerization interface [polypeptide binding]; other site 1168290004959 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1168290004960 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1168290004961 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1168290004962 active site 1168290004963 catalytic site [active] 1168290004964 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1168290004965 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290004966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1168290004967 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1168290004968 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1168290004969 dimer interface [polypeptide binding]; other site 1168290004970 FMN binding site [chemical binding]; other site 1168290004971 NADPH bind site [chemical binding]; other site 1168290004972 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1168290004973 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1168290004974 active site 1168290004975 catalytic triad [active] 1168290004976 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1168290004977 RelB antitoxin; Region: RelB; cl01171 1168290004978 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1168290004979 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1168290004980 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1168290004981 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1168290004982 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1168290004983 dimerization interface [polypeptide binding]; other site 1168290004984 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1168290004985 ligand binding site [chemical binding]; other site 1168290004986 NAD-dependent deacetylase; Provisional; Region: PRK00481 1168290004987 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1168290004988 threonine dehydratase; Provisional; Region: PRK08198 1168290004989 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1168290004990 tetramer interface [polypeptide binding]; other site 1168290004991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1168290004992 catalytic residue [active] 1168290004993 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1168290004994 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1168290004995 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1168290004996 Ca binding site [ion binding]; other site 1168290004997 active site 1168290004998 catalytic site [active] 1168290004999 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1168290005000 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; pfam05691 1168290005001 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1168290005002 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290005003 dimer interface [polypeptide binding]; other site 1168290005004 conserved gate region; other site 1168290005005 putative PBP binding loops; other site 1168290005006 ABC-ATPase subunit interface; other site 1168290005007 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1168290005008 dimer interface [polypeptide binding]; other site 1168290005009 conserved gate region; other site 1168290005010 putative PBP binding loops; other site 1168290005011 ABC-ATPase subunit interface; other site 1168290005012 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1168290005013 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1168290005014 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1168290005015 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1168290005016 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1168290005017 Melibiase; Region: Melibiase; pfam02065 1168290005018 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1168290005019 nucleoside/Zn binding site; other site 1168290005020 dimer interface [polypeptide binding]; other site 1168290005021 catalytic motif [active] 1168290005022 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1168290005023 Predicted esterase [General function prediction only]; Region: COG0400 1168290005024 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1168290005025 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1168290005026 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1168290005027 trimer interface [polypeptide binding]; other site 1168290005028 active site 1168290005029 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1168290005030 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1168290005031 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1168290005032 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1168290005033 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1168290005034 motif II; other site 1168290005035 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1168290005036 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1168290005037 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1168290005038 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1168290005039 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1168290005040 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1168290005041 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1168290005042 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1168290005043 Walker A/P-loop; other site 1168290005044 ATP binding site [chemical binding]; other site 1168290005045 Q-loop/lid; other site 1168290005046 ABC transporter signature motif; other site 1168290005047 Walker B; other site 1168290005048 D-loop; other site 1168290005049 H-loop/switch region; other site 1168290005050 TOBE domain; Region: TOBE_2; pfam08402 1168290005051 Ion channel; Region: Ion_trans_2; pfam07885 1168290005052 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1168290005053 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1168290005054 active site 1168290005055 ATP binding site [chemical binding]; other site 1168290005056 substrate binding site [chemical binding]; other site 1168290005057 activation loop (A-loop); other site 1168290005058 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1168290005059 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1168290005060 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1168290005061 G5 domain; Region: G5; pfam07501 1168290005062 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1168290005063 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1168290005064 catalytic residue [active] 1168290005065 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1168290005066 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1168290005067 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1168290005068 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1168290005069 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1168290005070 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1168290005071 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1168290005072 active site 1168290005073 NTP binding site [chemical binding]; other site 1168290005074 metal binding triad [ion binding]; metal-binding site 1168290005075 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1168290005076 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1168290005077 Zn2+ binding site [ion binding]; other site 1168290005078 Mg2+ binding site [ion binding]; other site 1168290005079 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1168290005080 active site 1168290005081 Ap6A binding site [chemical binding]; other site 1168290005082 nudix motif; other site 1168290005083 metal binding site [ion binding]; metal-binding site 1168290005084 integral membrane protein MviN; Region: mviN; TIGR01695 1168290005085 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1168290005086 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1168290005087 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1168290005088 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1168290005089 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1168290005090 ParB-like nuclease domain; Region: ParB; smart00470 1168290005091 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1168290005092 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1168290005093 P-loop; other site 1168290005094 Magnesium ion binding site [ion binding]; other site 1168290005095 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1168290005096 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1168290005097 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1168290005098 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1168290005099 G-X-X-G motif; other site 1168290005100 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1168290005101 RxxxH motif; other site 1168290005102 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1168290005103 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1168290005104 IncFII RepA protein family; Region: IncFII_repA; cl11495 1168290005105 hypothetical protein; Provisional; Region: PRK14372 1168290005106 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1168290005107 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399