-- dump date   	20140619_001906
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
552531000001	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552531000002	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
552531000003	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
552531000004	Transposase; Region: DDE_Tnp_ISL3; pfam01610
552531000005	Protein of unknown function DUF262; Region: DUF262; pfam03235
552531000006	Uncharacterized conserved protein [Function unknown]; Region: COG1479
552531000007	Protein of unknown function DUF262; Region: DUF262; pfam03235
552531000008	maltose O-acetyltransferase; Provisional; Region: PRK10092
552531000009	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
552531000010	active site
552531000011	substrate binding site [chemical binding]; other site
552531000012	trimer interface [polypeptide binding]; other site
552531000013	CoA binding site [chemical binding]; other site
552531000014	aconitate hydratase; Validated; Region: PRK09277
552531000015	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
552531000016	substrate binding site [chemical binding]; other site
552531000017	ligand binding site [chemical binding]; other site
552531000018	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
552531000019	substrate binding site [chemical binding]; other site
552531000020	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
552531000021	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552531000022	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
552531000023	Soluble P-type ATPase [General function prediction only]; Region: COG4087
552531000024	Protein of unknown function (DUF418); Region: DUF418; cl12135
552531000025	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
552531000026	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
552531000027	TRAM domain; Region: TRAM; cl01282
552531000028	Protein of unknown function (DUF3159); Region: DUF3159; pfam11361
552531000029	Protein of unknown function (DUF3710); Region: DUF3710; pfam12502
552531000030	Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281
552531000031	putative active site [active]
552531000032	putative catalytic site [active]
552531000033	putative DNA binding site [nucleotide binding]; other site
552531000034	putative phosphate binding site [ion binding]; other site
552531000035	metal binding site A [ion binding]; metal-binding site
552531000036	putative AP binding site [nucleotide binding]; other site
552531000037	putative metal binding site B [ion binding]; other site
552531000038	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
552531000039	AAA domain; Region: AAA_21; pfam13304
552531000040	Walker A/P-loop; other site
552531000041	ATP binding site [chemical binding]; other site
552531000042	Q-loop/lid; other site
552531000043	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
552531000044	ABC transporter signature motif; other site
552531000045	Walker B; other site
552531000046	D-loop; other site
552531000047	H-loop/switch region; other site
552531000048	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
552531000049	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
552531000050	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
552531000051	Walker A/P-loop; other site
552531000052	ATP binding site [chemical binding]; other site
552531000053	Q-loop/lid; other site
552531000054	ABC transporter signature motif; other site
552531000055	Walker B; other site
552531000056	D-loop; other site
552531000057	H-loop/switch region; other site
552531000058	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
552531000059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531000060	dimer interface [polypeptide binding]; other site
552531000061	conserved gate region; other site
552531000062	putative PBP binding loops; other site
552531000063	ABC-ATPase subunit interface; other site
552531000064	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
552531000065	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
552531000066	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
552531000067	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
552531000068	active site
552531000069	DNA binding site [nucleotide binding]
552531000070	Int/Topo IB signature motif; other site
552531000071	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552531000072	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552531000073	Walker A/P-loop; other site
552531000074	ATP binding site [chemical binding]; other site
552531000075	Q-loop/lid; other site
552531000076	ABC transporter signature motif; other site
552531000077	Walker B; other site
552531000078	D-loop; other site
552531000079	H-loop/switch region; other site
552531000080	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
552531000081	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552531000082	FtsX-like permease family; Region: FtsX; pfam02687
552531000083	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552531000084	FtsX-like permease family; Region: FtsX; pfam02687
552531000085	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
552531000086	prephenate dehydrogenase; Validated; Region: PRK08507
552531000087	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
552531000088	Prephenate dehydratase; Region: PDT; pfam00800
552531000089	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
552531000090	putative L-Phe binding site [chemical binding]; other site
552531000091	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
552531000092	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
552531000093	G1 box; other site
552531000094	putative GEF interaction site [polypeptide binding]; other site
552531000095	GTP/Mg2+ binding site [chemical binding]; other site
552531000096	Switch I region; other site
552531000097	G2 box; other site
552531000098	G3 box; other site
552531000099	Switch II region; other site
552531000100	G4 box; other site
552531000101	G5 box; other site
552531000102	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
552531000103	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
552531000104	benzoate transport; Region: 2A0115; TIGR00895
552531000105	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531000106	putative substrate translocation pore; other site
552531000107	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
552531000108	nudix motif; other site
552531000109	Uncharacterized conserved protein [General function prediction only]; Region: COG4111
552531000110	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
552531000111	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
552531000112	P-loop; other site
552531000113	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
552531000114	Magnesium ion binding site [ion binding]; other site
552531000115	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
552531000116	Magnesium ion binding site [ion binding]; other site
552531000117	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
552531000118	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
552531000119	active site
552531000120	Int/Topo IB signature motif; other site
552531000121	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
552531000122	23S rRNA binding site [nucleotide binding]; other site
552531000123	L21 binding site [polypeptide binding]; other site
552531000124	L13 binding site [polypeptide binding]; other site
552531000125	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
552531000126	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
552531000127	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
552531000128	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
552531000129	Thiamine pyrophosphokinase; Region: TPK; cd07995
552531000130	active site
552531000131	dimerization interface [polypeptide binding]; other site
552531000132	thiamine binding site [chemical binding]; other site
552531000133	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
552531000134	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
552531000135	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
552531000136	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
552531000137	putative deacylase active site [active]
552531000138	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
552531000139	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
552531000140	Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022
552531000141	active site
552531000142	catalytic residues [active]
552531000143	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
552531000144	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
552531000145	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
552531000146	DNA binding residues [nucleotide binding]
552531000147	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
552531000148	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
552531000149	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552531000150	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
552531000151	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
552531000152	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
552531000153	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
552531000154	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552531000155	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
552531000156	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
552531000157	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552531000158	active site
552531000159	phosphorylation site [posttranslational modification]
552531000160	intermolecular recognition site; other site
552531000161	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
552531000162	DNA binding residues [nucleotide binding]
552531000163	dimerization interface [polypeptide binding]; other site
552531000164	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
552531000165	Histidine kinase; Region: HisKA_3; pfam07730
552531000166	proline aminopeptidase P II; Provisional; Region: PRK10879
552531000167	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
552531000168	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
552531000169	active site
552531000170	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676
552531000171	nudix motif; other site
552531000172	MarR family; Region: MarR_2; cl17246
552531000173	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552531000174	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
552531000175	nucleotide binding site [chemical binding]; other site
552531000176	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
552531000177	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
552531000178	putative substrate binding site [chemical binding]; other site
552531000179	putative ATP binding site [chemical binding]; other site
552531000180	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
552531000181	putative active site [active]
552531000182	dimerization interface [polypeptide binding]; other site
552531000183	putative tRNAtyr binding site [nucleotide binding]; other site
552531000184	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
552531000185	active site
552531000186	DNA binding site [nucleotide binding]
552531000187	Int/Topo IB signature motif; other site
552531000188	Helix-turn-helix domain; Region: HTH_17; pfam12728
552531000189	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
552531000190	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
552531000191	Walker A motif; other site
552531000192	ATP binding site [chemical binding]; other site
552531000193	Walker B motif; other site
552531000194	Caudovirus prohead protease; Region: Peptidase_U35; cl01521
552531000195	Phage capsid family; Region: Phage_capsid; pfam05065
552531000196	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
552531000197	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
552531000198	Walker A/P-loop; other site
552531000199	ATP binding site [chemical binding]; other site
552531000200	Q-loop/lid; other site
552531000201	ABC transporter signature motif; other site
552531000202	Walker B; other site
552531000203	D-loop; other site
552531000204	H-loop/switch region; other site
552531000205	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
552531000206	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
552531000207	Walker A/P-loop; other site
552531000208	ATP binding site [chemical binding]; other site
552531000209	Q-loop/lid; other site
552531000210	ABC transporter signature motif; other site
552531000211	Walker B; other site
552531000212	D-loop; other site
552531000213	H-loop/switch region; other site
552531000214	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
552531000215	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
552531000216	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
552531000217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531000218	dimer interface [polypeptide binding]; other site
552531000219	conserved gate region; other site
552531000220	ABC-ATPase subunit interface; other site
552531000221	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
552531000222	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531000223	dimer interface [polypeptide binding]; other site
552531000224	conserved gate region; other site
552531000225	putative PBP binding loops; other site
552531000226	ABC-ATPase subunit interface; other site
552531000227	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
552531000228	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
552531000229	cell division protein FtsQ; Provisional; Region: PRK05529
552531000230	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
552531000231	Cell division protein FtsQ; Region: FtsQ; pfam03799
552531000232	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
552531000233	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
552531000234	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552531000235	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
552531000236	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
552531000237	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438
552531000238	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
552531000239	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552531000240	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
552531000241	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
552531000242	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
552531000243	Mg++ binding site [ion binding]; other site
552531000244	putative catalytic motif [active]
552531000245	putative substrate binding site [chemical binding]; other site
552531000246	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
552531000247	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
552531000248	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552531000249	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
552531000250	putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929
552531000251	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
552531000252	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
552531000253	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
552531000254	MraW methylase family; Region: Methyltransf_5; cl17771
552531000255	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
552531000256	MraZ protein; Region: MraZ; pfam02381
552531000257	cell division protein MraZ; Reviewed; Region: PRK00326
552531000258	MraZ protein; Region: MraZ; pfam02381
552531000259	Part of AAA domain; Region: AAA_19; pfam13245
552531000260	Family description; Region: UvrD_C_2; pfam13538
552531000261	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790
552531000262	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176
552531000263	ligand binding site [chemical binding]; other site
552531000264	NAD binding site [chemical binding]; other site
552531000265	tetramer interface [polypeptide binding]; other site
552531000266	catalytic site [active]
552531000267	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
552531000268	L-serine binding site [chemical binding]; other site
552531000269	ACT domain interface; other site
552531000270	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
552531000271	ATP cone domain; Region: ATP-cone; pfam03477
552531000272	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
552531000273	LexA repressor; Validated; Region: PRK00215
552531000274	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
552531000275	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
552531000276	Catalytic site [active]
552531000277	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
552531000278	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
552531000279	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
552531000280	NAD binding site [chemical binding]; other site
552531000281	dimer interface [polypeptide binding]; other site
552531000282	substrate binding site [chemical binding]; other site
552531000283	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552531000284	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
552531000285	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
552531000286	HflX GTPase family; Region: HflX; cd01878
552531000287	G1 box; other site
552531000288	GTP/Mg2+ binding site [chemical binding]; other site
552531000289	Switch I region; other site
552531000290	G2 box; other site
552531000291	G3 box; other site
552531000292	Switch II region; other site
552531000293	G4 box; other site
552531000294	G5 box; other site
552531000295	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
552531000296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552531000297	S-adenosylmethionine binding site [chemical binding]; other site
552531000298	ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967
552531000299	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552531000300	ATP binding site [chemical binding]; other site
552531000301	putative Mg++ binding site [ion binding]; other site
552531000302	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531000303	nucleotide binding region [chemical binding]; other site
552531000304	ATP-binding site [chemical binding]; other site
552531000305	Helicase associated domain (HA2); Region: HA2; pfam04408
552531000306	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
552531000307	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
552531000308	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
552531000309	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
552531000310	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
552531000311	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
552531000312	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
552531000313	catalytic residues [active]
552531000314	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
552531000315	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
552531000316	putative active site [active]
552531000317	oxyanion strand; other site
552531000318	catalytic triad [active]
552531000319	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
552531000320	putative active site pocket [active]
552531000321	4-fold oligomerization interface [polypeptide binding]; other site
552531000322	metal binding residues [ion binding]; metal-binding site
552531000323	3-fold/trimer interface [polypeptide binding]; other site
552531000324	histidinol-phosphate aminotransferase; Provisional; Region: PRK03317
552531000325	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531000326	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531000327	homodimer interface [polypeptide binding]; other site
552531000328	catalytic residue [active]
552531000329	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
552531000330	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
552531000331	NAD binding site [chemical binding]; other site
552531000332	dimerization interface [polypeptide binding]; other site
552531000333	product binding site; other site
552531000334	substrate binding site [chemical binding]; other site
552531000335	zinc binding site [ion binding]; other site
552531000336	catalytic residues [active]
552531000337	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
552531000338	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
552531000339	active site
552531000340	PHP Thumb interface [polypeptide binding]; other site
552531000341	metal binding site [ion binding]; metal-binding site
552531000342	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
552531000343	generic binding surface I; other site
552531000344	generic binding surface II; other site
552531000345	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
552531000346	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
552531000347	RNA binding surface [nucleotide binding]; other site
552531000348	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
552531000349	active site
552531000350	lipoprotein signal peptidase; Provisional; Region: PRK14771
552531000351	DivIVA protein; Region: DivIVA; pfam05103
552531000352	DivIVA domain; Region: DivI1A_domain; TIGR03544
552531000353	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
552531000354	YGGT family; Region: YGGT; pfam02325
552531000355	Protein of unknown function (DUF552); Region: DUF552; pfam04472
552531000356	cell division protein FtsZ; Validated; Region: PRK09330
552531000357	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
552531000358	nucleotide binding site [chemical binding]; other site
552531000359	SulA interaction site; other site
552531000360	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
552531000361	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
552531000362	FMN binding site [chemical binding]; other site
552531000363	active site
552531000364	catalytic residues [active]
552531000365	substrate binding site [chemical binding]; other site
552531000366	glycyl-tRNA synthetase; Provisional; Region: PRK04173
552531000367	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
552531000368	motif 1; other site
552531000369	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
552531000370	active site
552531000371	motif 2; other site
552531000372	motif 3; other site
552531000373	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
552531000374	anticodon binding site; other site
552531000375	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
552531000376	thiamine phosphate binding site [chemical binding]; other site
552531000377	active site
552531000378	pyrophosphate binding site [ion binding]; other site
552531000379	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
552531000380	substrate binding site [chemical binding]; other site
552531000381	dimer interface [polypeptide binding]; other site
552531000382	ATP binding site [chemical binding]; other site
552531000383	Domain of unknown function DUF77; Region: DUF77; pfam01910
552531000384	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531000385	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531000386	DNA binding site [nucleotide binding]
552531000387	domain linker motif; other site
552531000388	Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288
552531000389	putative dimerization interface [polypeptide binding]; other site
552531000390	putative ligand binding site [chemical binding]; other site
552531000391	galactoside permease; Reviewed; Region: lacY; PRK09528
552531000392	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531000393	putative substrate translocation pore; other site
552531000394	Glycosyl hydrolases family 32; Region: Glyco_32; smart00640
552531000395	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
552531000396	substrate binding [chemical binding]; other site
552531000397	active site
552531000398	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
552531000399	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
552531000400	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531000401	dimer interface [polypeptide binding]; other site
552531000402	conserved gate region; other site
552531000403	putative PBP binding loops; other site
552531000404	ABC-ATPase subunit interface; other site
552531000405	NMT1/THI5 like; Region: NMT1; pfam09084
552531000406	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
552531000407	nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity.  This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226
552531000408	active site
552531000409	undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829
552531000410	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
552531000411	catalytic residue [active]
552531000412	putative FPP diphosphate  binding site; other site
552531000413	putative FPP binding hydrophobic cleft; other site
552531000414	dimer interface [polypeptide binding]; other site
552531000415	putative IPP diphosphate binding site; other site
552531000416	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
552531000417	Recombination protein O N terminal; Region: RecO_N; pfam11967
552531000418	Recombination protein O C terminal; Region: RecO_C; pfam02565
552531000419	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
552531000420	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
552531000421	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
552531000422	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
552531000423	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
552531000424	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
552531000425	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
552531000426	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
552531000427	DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543
552531000428	DivIVA domain; Region: DivI1A_domain; TIGR03544
552531000429	DivIVA domain; Region: DivI1A_domain; TIGR03544
552531000430	Protein of unknown function (DUF3052); Region: DUF3052; pfam11253
552531000431	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
552531000432	Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103
552531000433	uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883
552531000434	UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580
552531000435	Part of AAA domain; Region: AAA_19; pfam13245
552531000436	Family description; Region: UvrD_C_2; pfam13538
552531000437	Phosphotransferase enzyme family; Region: APH; pfam01636
552531000438	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
552531000439	substrate binding site [chemical binding]; other site
552531000440	Protein of unknown function (DUF3107); Region: DUF3107; pfam11305
552531000441	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
552531000442	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
552531000443	active site
552531000444	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
552531000445	Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922
552531000446	putative active site [active]
552531000447	redox center [active]
552531000448	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
552531000449	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
552531000450	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
552531000451	glutamate racemase; Provisional; Region: PRK00865
552531000452	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
552531000453	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
552531000454	active site
552531000455	nucleophile elbow; other site
552531000456	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
552531000457	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
552531000458	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
552531000459	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552531000460	substrate binding pocket [chemical binding]; other site
552531000461	membrane-bound complex binding site; other site
552531000462	hinge residues; other site
552531000463	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
552531000464	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531000465	Walker A/P-loop; other site
552531000466	ATP binding site [chemical binding]; other site
552531000467	Q-loop/lid; other site
552531000468	ABC transporter signature motif; other site
552531000469	Walker B; other site
552531000470	D-loop; other site
552531000471	H-loop/switch region; other site
552531000472	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
552531000473	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531000474	dimer interface [polypeptide binding]; other site
552531000475	conserved gate region; other site
552531000476	putative PBP binding loops; other site
552531000477	ABC-ATPase subunit interface; other site
552531000478	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
552531000479	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531000480	dimer interface [polypeptide binding]; other site
552531000481	conserved gate region; other site
552531000482	putative PBP binding loops; other site
552531000483	ABC-ATPase subunit interface; other site
552531000484	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
552531000485	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531000486	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531000487	homodimer interface [polypeptide binding]; other site
552531000488	catalytic residue [active]
552531000489	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531000490	putative PBP binding loops; other site
552531000491	ABC-ATPase subunit interface; other site
552531000492	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
552531000493	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
552531000494	Walker A/P-loop; other site
552531000495	ATP binding site [chemical binding]; other site
552531000496	Q-loop/lid; other site
552531000497	ABC transporter signature motif; other site
552531000498	Walker B; other site
552531000499	D-loop; other site
552531000500	H-loop/switch region; other site
552531000501	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
552531000502	NIL domain; Region: NIL; pfam09383
552531000503	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
552531000504	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
552531000505	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
552531000506	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
552531000507	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
552531000508	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
552531000509	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
552531000510	active site
552531000511	catalytic site [active]
552531000512	substrate binding site [chemical binding]; other site
552531000513	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
552531000514	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
552531000515	G1 box; other site
552531000516	putative GEF interaction site [polypeptide binding]; other site
552531000517	GTP/Mg2+ binding site [chemical binding]; other site
552531000518	Switch I region; other site
552531000519	G2 box; other site
552531000520	G3 box; other site
552531000521	Switch II region; other site
552531000522	G4 box; other site
552531000523	G5 box; other site
552531000524	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
552531000525	Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789
552531000526	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
552531000527	transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905
552531000528	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
552531000529	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
552531000530	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531000531	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531000532	putative substrate translocation pore; other site
552531000533	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
552531000534	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
552531000535	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
552531000536	HIGH motif; other site
552531000537	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
552531000538	active site
552531000539	KMSKS motif; other site
552531000540	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
552531000541	tRNA binding surface [nucleotide binding]; other site
552531000542	anticodon binding site; other site
552531000543	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
552531000544	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
552531000545	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552531000546	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552531000547	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
552531000548	Walker A/P-loop; other site
552531000549	ATP binding site [chemical binding]; other site
552531000550	Q-loop/lid; other site
552531000551	ABC transporter signature motif; other site
552531000552	Walker B; other site
552531000553	D-loop; other site
552531000554	H-loop/switch region; other site
552531000555	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552531000556	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552531000557	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531000558	Walker A/P-loop; other site
552531000559	ATP binding site [chemical binding]; other site
552531000560	Q-loop/lid; other site
552531000561	ABC transporter signature motif; other site
552531000562	Walker B; other site
552531000563	D-loop; other site
552531000564	H-loop/switch region; other site
552531000565	MarR family; Region: MarR_2; pfam12802
552531000566	Transcriptional regulators [Transcription]; Region: MarR; COG1846
552531000567	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
552531000568	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
552531000569	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
552531000570	additional DNA contacts [nucleotide binding]; other site
552531000571	mismatch recognition site; other site
552531000572	active site
552531000573	zinc binding site [ion binding]; other site
552531000574	DNA intercalation site [nucleotide binding]; other site
552531000575	CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764
552531000576	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
552531000577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
552531000578	CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165
552531000579	CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834
552531000580	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
552531000581	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
552531000582	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
552531000583	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
552531000584	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
552531000585	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
552531000586	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580
552531000587	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
552531000588	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
552531000589	Protein of unknown function (DUF1211); Region: DUF1211; pfam06736
552531000590	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
552531000591	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
552531000592	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552531000593	FeS/SAM binding site; other site
552531000594	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
552531000595	ATP cone domain; Region: ATP-cone; pfam03477
552531000596	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
552531000597	Class III ribonucleotide reductase; Region: RNR_III; cd01675
552531000598	active site
552531000599	Zn binding site [ion binding]; other site
552531000600	glycine loop; other site
552531000601	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
552531000602	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
552531000603	generic binding surface II; other site
552531000604	generic binding surface I; other site
552531000605	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
552531000606	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
552531000607	putative catalytic site [active]
552531000608	putative metal binding site [ion binding]; other site
552531000609	putative phosphate binding site [ion binding]; other site
552531000610	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
552531000611	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531000612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531000613	homodimer interface [polypeptide binding]; other site
552531000614	catalytic residue [active]
552531000615	Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221
552531000616	additional DNA contacts [nucleotide binding]; other site
552531000617	mismatch recognition site; other site
552531000618	active site
552531000619	zinc binding site [ion binding]; other site
552531000620	DNA intercalation site [nucleotide binding]; other site
552531000621	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
552531000622	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
552531000623	active site
552531000624	catalytic site [active]
552531000625	substrate binding site [chemical binding]; other site
552531000626	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
552531000627	active site
552531000628	catalytic residues [active]
552531000629	metal binding site [ion binding]; metal-binding site
552531000630	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318
552531000631	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
552531000632	active site
552531000633	substrate binding site [chemical binding]; other site
552531000634	metal binding site [ion binding]; metal-binding site
552531000635	aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412
552531000636	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602
552531000637	Zn binding site [ion binding]; other site
552531000638	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
552531000639	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
552531000640	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
552531000641	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
552531000642	dihydrodipicolinate synthase; Region: dapA; TIGR00674
552531000643	dimer interface [polypeptide binding]; other site
552531000644	active site
552531000645	catalytic residue [active]
552531000646	dihydrodipicolinate reductase; Provisional; Region: PRK00048
552531000647	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
552531000648	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
552531000649	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531000650	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531000651	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552531000652	Coenzyme A binding pocket [chemical binding]; other site
552531000653	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
552531000654	Family description; Region: UvrD_C_2; pfam13538
552531000655	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
552531000656	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
552531000657	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
552531000658	Catalytic domain of Protein Kinases; Region: PKc; cd00180
552531000659	active site
552531000660	ATP binding site [chemical binding]; other site
552531000661	substrate binding site [chemical binding]; other site
552531000662	activation loop (A-loop); other site
552531000663	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
552531000664	Interdomain contacts; other site
552531000665	Cytokine receptor motif; other site
552531000666	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
552531000667	Interdomain contacts; other site
552531000668	Cytokine receptor motif; other site
552531000669	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
552531000670	Protein of unknown function DUF58; Region: DUF58; pfam01882
552531000671	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
552531000672	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
552531000673	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
552531000674	phosphopeptide binding site; other site
552531000675	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
552531000676	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
552531000677	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
552531000678	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
552531000679	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
552531000680	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
552531000681	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
552531000682	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
552531000683	DNA binding site [nucleotide binding]
552531000684	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
552531000685	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
552531000686	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
552531000687	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
552531000688	RPB1 interaction site [polypeptide binding]; other site
552531000689	RPB10 interaction site [polypeptide binding]; other site
552531000690	RPB11 interaction site [polypeptide binding]; other site
552531000691	RPB3 interaction site [polypeptide binding]; other site
552531000692	RPB12 interaction site [polypeptide binding]; other site
552531000693	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
552531000694	endonuclease III; Region: ENDO3c; smart00478
552531000695	minor groove reading motif; other site
552531000696	helix-hairpin-helix signature motif; other site
552531000697	substrate binding pocket [chemical binding]; other site
552531000698	active site
552531000699	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
552531000700	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
552531000701	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
552531000702	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
552531000703	active site
552531000704	catalytic site [active]
552531000705	Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153
552531000706	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
552531000707	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
552531000708	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
552531000709	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
552531000710	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
552531000711	dimer interface [polypeptide binding]; other site
552531000712	active site
552531000713	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
552531000714	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552531000715	DNA-binding site [nucleotide binding]; DNA binding site
552531000716	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
552531000717	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
552531000718	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
552531000719	quinone interaction residues [chemical binding]; other site
552531000720	active site
552531000721	catalytic residues [active]
552531000722	FMN binding site [chemical binding]; other site
552531000723	substrate binding site [chemical binding]; other site
552531000724	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
552531000725	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
552531000726	active site
552531000727	FMN binding site [chemical binding]; other site
552531000728	substrate binding site [chemical binding]; other site
552531000729	homotetramer interface [polypeptide binding]; other site
552531000730	catalytic residue [active]
552531000731	Transglycosylase; Region: Transgly; pfam00912
552531000732	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
552531000733	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
552531000734	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
552531000735	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
552531000736	ligand binding site [chemical binding]; other site
552531000737	flexible hinge region; other site
552531000738	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
552531000739	putative switch regulator; other site
552531000740	non-specific DNA interactions [nucleotide binding]; other site
552531000741	DNA binding site [nucleotide binding]
552531000742	sequence specific DNA binding site [nucleotide binding]; other site
552531000743	putative cAMP binding site [chemical binding]; other site
552531000744	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
552531000745	TM2 domain; Region: TM2; pfam05154
552531000746	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
552531000747	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
552531000748	Uncharacterized conserved protein [Function unknown]; Region: COG4850
552531000749	Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949
552531000750	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
552531000751	lipoyl attachment site [posttranslational modification]; other site
552531000752	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
552531000753	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
552531000754	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
552531000755	putative NADH binding site [chemical binding]; other site
552531000756	putative active site [active]
552531000757	nudix motif; other site
552531000758	putative metal binding site [ion binding]; other site
552531000759	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
552531000760	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
552531000761	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
552531000762	catalytic residues [active]
552531000763	Domain of unknown function (DUF348); Region: DUF348; pfam03990
552531000764	G5 domain; Region: G5; pfam07501
552531000765	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
552531000766	N-acetyl-D-glucosamine binding site [chemical binding]; other site
552531000767	catalytic residue [active]
552531000768	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
552531000769	Bacterial sugar transferase; Region: Bac_transf; pfam02397
552531000770	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
552531000771	glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182
552531000772	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
552531000773	Ligand binding site; other site
552531000774	Putative Catalytic site; other site
552531000775	DXD motif; other site
552531000776	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
552531000777	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
552531000778	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
552531000779	substrate binding site; other site
552531000780	tetramer interface; other site
552531000781	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
552531000782	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
552531000783	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
552531000784	NADP binding site [chemical binding]; other site
552531000785	active site
552531000786	putative substrate binding site [chemical binding]; other site
552531000787	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
552531000788	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
552531000789	NAD binding site [chemical binding]; other site
552531000790	substrate binding site [chemical binding]; other site
552531000791	homodimer interface [polypeptide binding]; other site
552531000792	active site
552531000793	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
552531000794	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
552531000795	Probable Catalytic site; other site
552531000796	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
552531000797	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
552531000798	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
552531000799	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
552531000800	active site
552531000801	putative glycosyl transferase; Provisional; Region: PRK10073
552531000802	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
552531000803	active site
552531000804	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
552531000805	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
552531000806	active site
552531000807	Domain of unknown function (DUF4422); Region: DUF4422; pfam14393
552531000808	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
552531000809	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
552531000810	active site
552531000811	Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704
552531000812	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
552531000813	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
552531000814	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
552531000815	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
552531000816	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
552531000817	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
552531000818	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
552531000819	active site
552531000820	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
552531000821	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
552531000822	Bacterial sugar transferase; Region: Bac_transf; pfam02397
552531000823	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531000824	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531000825	putative substrate translocation pore; other site
552531000826	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531000827	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
552531000828	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
552531000829	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
552531000830	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
552531000831	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
552531000832	active site
552531000833	multimer interface [polypeptide binding]; other site
552531000834	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
552531000835	predicted active site [active]
552531000836	catalytic triad [active]
552531000837	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
552531000838	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
552531000839	putative NAD(P) binding site [chemical binding]; other site
552531000840	active site
552531000841	putative substrate binding site [chemical binding]; other site
552531000842	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
552531000843	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
552531000844	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
552531000845	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
552531000846	active site
552531000847	RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526
552531000848	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
552531000849	Ligand binding site; other site
552531000850	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552531000851	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
552531000852	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531000853	Walker A/P-loop; other site
552531000854	ATP binding site [chemical binding]; other site
552531000855	Q-loop/lid; other site
552531000856	ABC transporter signature motif; other site
552531000857	Walker B; other site
552531000858	D-loop; other site
552531000859	H-loop/switch region; other site
552531000860	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552531000861	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531000862	Walker A/P-loop; other site
552531000863	ATP binding site [chemical binding]; other site
552531000864	Q-loop/lid; other site
552531000865	ABC transporter signature motif; other site
552531000866	Walker B; other site
552531000867	D-loop; other site
552531000868	H-loop/switch region; other site
552531000869	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
552531000870	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
552531000871	acyl-activating enzyme (AAE) consensus motif; other site
552531000872	putative AMP binding site [chemical binding]; other site
552531000873	putative active site [active]
552531000874	putative CoA binding site [chemical binding]; other site
552531000875	Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276
552531000876	putative active site [active]
552531000877	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
552531000878	dimer interface [polypeptide binding]; other site
552531000879	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
552531000880	nudix motif; other site
552531000881	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
552531000882	Low molecular weight phosphatase family; Region: LMWPc; cd00115
552531000883	active site
552531000884	Protein of unknown function (DUF4012); Region: DUF4012; pfam13196
552531000885	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
552531000886	Chain length determinant protein; Region: Wzz; cl15801
552531000887	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
552531000888	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
552531000889	Nucleotide binding site [chemical binding]; other site
552531000890	DTAP/Switch II; other site
552531000891	Switch I; other site
552531000892	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
552531000893	Transposase; Region: DDE_Tnp_ISL3; pfam01610
552531000894	homoserine kinase; Provisional; Region: PRK01212
552531000895	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
552531000896	homoserine dehydrogenase; Provisional; Region: PRK06349
552531000897	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
552531000898	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
552531000899	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
552531000900	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
552531000901	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
552531000902	catalytic residue [active]
552531000903	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
552531000904	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
552531000905	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
552531000906	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
552531000907	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
552531000908	active site
552531000909	HIGH motif; other site
552531000910	KMSK motif region; other site
552531000911	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
552531000912	tRNA binding surface [nucleotide binding]; other site
552531000913	anticodon binding site; other site
552531000914	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
552531000915	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
552531000916	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
552531000917	homotrimer interaction site [polypeptide binding]; other site
552531000918	putative active site [active]
552531000919	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552531000920	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531000921	dimer interface [polypeptide binding]; other site
552531000922	conserved gate region; other site
552531000923	putative PBP binding loops; other site
552531000924	ABC-ATPase subunit interface; other site
552531000925	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
552531000926	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
552531000927	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
552531000928	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
552531000929	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
552531000930	hypothetical protein; Provisional; Region: PRK03298
552531000931	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
552531000932	gamma subunit interface [polypeptide binding]; other site
552531000933	epsilon subunit interface [polypeptide binding]; other site
552531000934	LBP interface [polypeptide binding]; other site
552531000935	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
552531000936	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
552531000937	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
552531000938	alpha subunit interaction interface [polypeptide binding]; other site
552531000939	Walker A motif; other site
552531000940	ATP binding site [chemical binding]; other site
552531000941	Walker B motif; other site
552531000942	inhibitor binding site; inhibition site
552531000943	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
552531000944	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
552531000945	core domain interface [polypeptide binding]; other site
552531000946	delta subunit interface [polypeptide binding]; other site
552531000947	epsilon subunit interface [polypeptide binding]; other site
552531000948	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
552531000949	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
552531000950	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
552531000951	beta subunit interaction interface [polypeptide binding]; other site
552531000952	Walker A motif; other site
552531000953	ATP binding site [chemical binding]; other site
552531000954	Walker B motif; other site
552531000955	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
552531000956	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430
552531000957	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
552531000958	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
552531000959	ATP synthase subunit C; Region: ATP-synt_C; cl00466
552531000960	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
552531000961	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
552531000962	homoserine O-succinyltransferase; Provisional; Region: PRK05368
552531000963	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
552531000964	proposed active site lysine [active]
552531000965	conserved cys residue [active]
552531000966	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531000967	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531000968	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
552531000969	active site
552531000970	tetramer interface [polypeptide binding]; other site
552531000971	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
552531000972	Plasmid replication protein; Region: Rep_2; pfam01719
552531000973	Protein of unknown function DUF262; Region: DUF262; pfam03235
552531000974	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
552531000975	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
552531000976	active site
552531000977	Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651
552531000978	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
552531000979	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
552531000980	Int/Topo IB signature motif; other site
552531000981	formyl-coenzyme A transferase; Provisional; Region: PRK05398
552531000982	CoA-transferase family III; Region: CoA_transf_3; pfam02515
552531000983	Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150
552531000984	Cellulose or protein binding domain; Region: CBM_10; pfam02013
552531000985	putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259
552531000986	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
552531000987	PYR/PP interface [polypeptide binding]; other site
552531000988	dimer interface [polypeptide binding]; other site
552531000989	TPP binding site [chemical binding]; other site
552531000990	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
552531000991	Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004
552531000992	TPP-binding site; other site
552531000993	dimer interface [polypeptide binding]; other site
552531000994	Voltage gated chloride channel; Region: Voltage_CLC; pfam00654
552531000995	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
552531000996	Cl- selectivity filter; other site
552531000997	Cl- binding residues [ion binding]; other site
552531000998	pore gating glutamate residue; other site
552531000999	dimer interface [polypeptide binding]; other site
552531001000	TQXA domain; Region: TQXA_dom; TIGR03934
552531001001	Cna protein B-type domain; Region: Cna_B; pfam05738
552531001002	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
552531001003	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
552531001004	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
552531001005	active site
552531001006	catalytic site [active]
552531001007	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
552531001008	dimer interface [polypeptide binding]; other site
552531001009	substrate binding site [chemical binding]; other site
552531001010	metal binding sites [ion binding]; metal-binding site
552531001011	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552531001012	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552531001013	DNA binding site [nucleotide binding]
552531001014	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
552531001015	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
552531001016	minor groove reading motif; other site
552531001017	helix-hairpin-helix signature motif; other site
552531001018	substrate binding pocket [chemical binding]; other site
552531001019	active site
552531001020	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
552531001021	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
552531001022	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
552531001023	valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208
552531001024	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
552531001025	active site
552531001026	HIGH motif; other site
552531001027	nucleotide binding site [chemical binding]; other site
552531001028	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
552531001029	active site
552531001030	KMSKS motif; other site
552531001031	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
552531001032	tRNA binding surface [nucleotide binding]; other site
552531001033	anticodon binding site; other site
552531001034	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
552531001035	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
552531001036	dimerization interface [polypeptide binding]; other site
552531001037	putative Zn2+ binding site [ion binding]; other site
552531001038	putative DNA binding site [nucleotide binding]; other site
552531001039	chorismate mutase; Provisional; Region: PRK09239
552531001040	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
552531001041	transcription termination factor Rho; Provisional; Region: PRK12608
552531001042	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
552531001043	RNA binding site [nucleotide binding]; other site
552531001044	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
552531001045	Walker A motif; other site
552531001046	ATP binding site [chemical binding]; other site
552531001047	Walker B motif; other site
552531001048	hypothetical protein; Provisional; Region: PRK07208
552531001049	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
552531001050	Protein of unknown function (DUF2469); Region: DUF2469; pfam10611
552531001051	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
552531001052	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
552531001053	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
552531001054	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
552531001055	GatB domain; Region: GatB_Yqey; pfam02637
552531001056	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
552531001057	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
552531001058	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
552531001059	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001060	ABC transporter signature motif; other site
552531001061	Walker B; other site
552531001062	D-loop; other site
552531001063	H-loop/switch region; other site
552531001064	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
552531001065	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309
552531001066	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
552531001067	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552531001068	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
552531001069	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
552531001070	Clp amino terminal domain; Region: Clp_N; pfam02861
552531001071	Clp amino terminal domain; Region: Clp_N; pfam02861
552531001072	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531001073	Walker A motif; other site
552531001074	ATP binding site [chemical binding]; other site
552531001075	Walker B motif; other site
552531001076	arginine finger; other site
552531001077	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531001078	Walker A motif; other site
552531001079	ATP binding site [chemical binding]; other site
552531001080	Walker B motif; other site
552531001081	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
552531001082	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
552531001083	4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303
552531001084	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
552531001085	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
552531001086	von Willebrand factor (vWF) type A domain; Region: VWA; smart00327
552531001087	metal ion-dependent adhesion site (MIDAS); other site
552531001088	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
552531001089	active site
552531001090	catalytic site [active]
552531001091	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
552531001092	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
552531001093	catalytic residue [active]
552531001094	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
552531001095	active site
552531001096	HIGH motif; other site
552531001097	nucleotide binding site [chemical binding]; other site
552531001098	active site
552531001099	KMSKS motif; other site
552531001100	Protein of unknown function (DUF3152); Region: DUF3152; pfam11350
552531001101	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
552531001102	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
552531001103	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
552531001104	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
552531001105	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
552531001106	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
552531001107	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
552531001108	dimer interface [polypeptide binding]; other site
552531001109	ssDNA binding site [nucleotide binding]; other site
552531001110	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552531001111	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
552531001112	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
552531001113	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
552531001114	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552531001115	active site
552531001116	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
552531001117	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
552531001118	substrate binding site [chemical binding]; other site
552531001119	dimer interface [polypeptide binding]; other site
552531001120	ATP binding site [chemical binding]; other site
552531001121	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531001122	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531001123	putative substrate translocation pore; other site
552531001124	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
552531001125	active site
552531001126	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531001127	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531001128	DNA binding site [nucleotide binding]
552531001129	domain linker motif; other site
552531001130	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
552531001131	dimerization interface [polypeptide binding]; other site
552531001132	ligand binding site [chemical binding]; other site
552531001133	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
552531001134	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
552531001135	UDP-galactopyranose mutase; Region: GLF; pfam03275
552531001136	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
552531001137	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
552531001138	active site
552531001139	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
552531001140	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
552531001141	active site
552531001142	Sulfatase; Region: Sulfatase; pfam00884
552531001143	Sulfatase; Region: Sulfatase; pfam00884
552531001144	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
552531001145	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
552531001146	active site
552531001147	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
552531001148	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
552531001149	active site
552531001150	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
552531001151	active site
552531001152	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
552531001153	S-layer homology domain; Region: SLH; pfam00395
552531001154	S-layer homology domain; Region: SLH; pfam00395
552531001155	S-layer homology domain; Region: SLH; pfam00395
552531001156	MULE transposase domain; Region: MULE; pfam10551
552531001157	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
552531001158	Leucine rich repeat; Region: LRR_8; pfam13855
552531001159	S-layer homology domain; Region: SLH; pfam00395
552531001160	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
552531001161	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
552531001162	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
552531001163	Walker A/P-loop; other site
552531001164	ATP binding site [chemical binding]; other site
552531001165	Q-loop/lid; other site
552531001166	ABC transporter signature motif; other site
552531001167	Walker B; other site
552531001168	D-loop; other site
552531001169	H-loop/switch region; other site
552531001170	ABC-2 type transporter; Region: ABC2_membrane; cl17235
552531001171	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
552531001172	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
552531001173	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
552531001174	active site
552531001175	Excalibur calcium-binding domain; Region: Excalibur; pfam05901
552531001176	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552531001177	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
552531001178	FtsX-like permease family; Region: FtsX; pfam02687
552531001179	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552531001180	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001181	ATP binding site [chemical binding]; other site
552531001182	Q-loop/lid; other site
552531001183	ABC transporter signature motif; other site
552531001184	Walker B; other site
552531001185	D-loop; other site
552531001186	H-loop/switch region; other site
552531001187	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552531001188	Zn2+ binding site [ion binding]; other site
552531001189	Mg2+ binding site [ion binding]; other site
552531001190	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
552531001191	putative active site [active]
552531001192	putative dimer interface [polypeptide binding]; other site
552531001193	YL1 nuclear protein; Region: YL1; pfam05764
552531001194	K+ potassium transporter; Region: K_trans; pfam02705
552531001195	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
552531001196	active site
552531001197	Melibiase; Region: Melibiase; pfam02065
552531001198	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552531001199	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552531001200	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
552531001201	Walker A/P-loop; other site
552531001202	ATP binding site [chemical binding]; other site
552531001203	Q-loop/lid; other site
552531001204	ABC transporter signature motif; other site
552531001205	Walker B; other site
552531001206	D-loop; other site
552531001207	H-loop/switch region; other site
552531001208	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552531001209	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552531001210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001211	Walker A/P-loop; other site
552531001212	ATP binding site [chemical binding]; other site
552531001213	Q-loop/lid; other site
552531001214	ABC transporter signature motif; other site
552531001215	Walker B; other site
552531001216	D-loop; other site
552531001217	H-loop/switch region; other site
552531001218	Predicted methyltransferases [General function prediction only]; Region: COG0313
552531001219	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
552531001220	putative SAM binding site [chemical binding]; other site
552531001221	putative homodimer interface [polypeptide binding]; other site
552531001222	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
552531001223	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
552531001224	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
552531001225	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
552531001226	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
552531001227	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
552531001228	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
552531001229	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
552531001230	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
552531001231	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552531001232	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552531001233	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
552531001234	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
552531001235	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531001236	motif II; other site
552531001237	Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766
552531001238	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
552531001239	DNA binding residues [nucleotide binding]
552531001240	putative dimer interface [polypeptide binding]; other site
552531001241	curved DNA-binding protein CbpA; Provisional; Region: PRK10266
552531001242	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
552531001243	HSP70 interaction site [polypeptide binding]; other site
552531001244	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
552531001245	substrate binding site [polypeptide binding]; other site
552531001246	dimer interface [polypeptide binding]; other site
552531001247	GrpE; Region: GrpE; pfam01025
552531001248	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
552531001249	dimer interface [polypeptide binding]; other site
552531001250	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
552531001251	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
552531001252	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
552531001253	nucleotide binding site [chemical binding]; other site
552531001254	NEF interaction site [polypeptide binding]; other site
552531001255	SBD interface [polypeptide binding]; other site
552531001256	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531001257	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531001258	DNA binding site [nucleotide binding]
552531001259	domain linker motif; other site
552531001260	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
552531001261	ligand binding site [chemical binding]; other site
552531001262	dimerization interface [polypeptide binding]; other site
552531001263	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
552531001264	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531001265	motif II; other site
552531001266	pullulanase, type I; Region: pulA_typeI; TIGR02104
552531001267	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
552531001268	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
552531001269	Ca binding site [ion binding]; other site
552531001270	active site
552531001271	catalytic site [active]
552531001272	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552531001273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531001274	dimer interface [polypeptide binding]; other site
552531001275	conserved gate region; other site
552531001276	putative PBP binding loops; other site
552531001277	ABC-ATPase subunit interface; other site
552531001278	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
552531001279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531001280	dimer interface [polypeptide binding]; other site
552531001281	conserved gate region; other site
552531001282	putative PBP binding loops; other site
552531001283	ABC-ATPase subunit interface; other site
552531001284	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552531001285	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
552531001286	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
552531001287	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
552531001288	active site
552531001289	catalytic site [active]
552531001290	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
552531001291	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
552531001292	Protein of unknown function, DUF624; Region: DUF624; pfam04854
552531001293	Protein of unknown function, DUF624; Region: DUF624; cl02369
552531001294	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552531001295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531001296	dimer interface [polypeptide binding]; other site
552531001297	conserved gate region; other site
552531001298	putative PBP binding loops; other site
552531001299	ABC-ATPase subunit interface; other site
552531001300	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552531001301	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531001302	dimer interface [polypeptide binding]; other site
552531001303	conserved gate region; other site
552531001304	putative PBP binding loops; other site
552531001305	ABC-ATPase subunit interface; other site
552531001306	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531001307	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531001308	DNA binding site [nucleotide binding]
552531001309	domain linker motif; other site
552531001310	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
552531001311	ligand binding site [chemical binding]; other site
552531001312	dimerization interface [polypeptide binding]; other site
552531001313	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
552531001314	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
552531001315	active site
552531001316	catalytic site [active]
552531001317	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
552531001318	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531001319	catalytic core [active]
552531001320	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531001321	Protein of unknown function (DUF4235); Region: DUF4235; pfam14019
552531001322	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
552531001323	dimer interface [polypeptide binding]; other site
552531001324	FMN binding site [chemical binding]; other site
552531001325	NADPH bind site [chemical binding]; other site
552531001326	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
552531001327	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
552531001328	active site
552531001329	catalytic triad [active]
552531001330	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
552531001331	dimer interface [polypeptide binding]; other site
552531001332	RelB antitoxin; Region: RelB; cl01171
552531001333	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
552531001334	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
552531001335	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
552531001336	Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944
552531001337	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531001338	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531001339	DNA binding site [nucleotide binding]
552531001340	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
552531001341	dimerization interface [polypeptide binding]; other site
552531001342	ligand binding site [chemical binding]; other site
552531001343	NAD-dependent deacetylase; Provisional; Region: PRK00481
552531001344	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
552531001345	threonine dehydratase; Provisional; Region: PRK08198
552531001346	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
552531001347	tetramer interface [polypeptide binding]; other site
552531001348	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531001349	catalytic residue [active]
552531001350	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
552531001351	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
552531001352	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
552531001353	Ca binding site [ion binding]; other site
552531001354	active site
552531001355	catalytic site [active]
552531001356	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
552531001357	Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; pfam05691
552531001358	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552531001359	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531001360	dimer interface [polypeptide binding]; other site
552531001361	conserved gate region; other site
552531001362	putative PBP binding loops; other site
552531001363	ABC-ATPase subunit interface; other site
552531001364	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531001365	dimer interface [polypeptide binding]; other site
552531001366	conserved gate region; other site
552531001367	putative PBP binding loops; other site
552531001368	ABC-ATPase subunit interface; other site
552531001369	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
552531001370	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
552531001371	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552531001372	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
552531001373	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
552531001374	Melibiase; Region: Melibiase; pfam02065
552531001375	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
552531001376	nucleoside/Zn binding site; other site
552531001377	dimer interface [polypeptide binding]; other site
552531001378	catalytic motif [active]
552531001379	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
552531001380	Predicted esterase [General function prediction only]; Region: COG0400
552531001381	Serine hydrolase (FSH1); Region: FSH1; pfam03959
552531001382	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
552531001383	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
552531001384	trimer interface [polypeptide binding]; other site
552531001385	active site
552531001386	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
552531001387	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
552531001388	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552531001389	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
552531001390	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531001391	motif II; other site
552531001392	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
552531001393	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
552531001394	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
552531001395	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
552531001396	Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488
552531001397	Domain of unknown function (DUF4032); Region: DUF4032; pfam13224
552531001398	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
552531001399	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
552531001400	Walker A/P-loop; other site
552531001401	ATP binding site [chemical binding]; other site
552531001402	Q-loop/lid; other site
552531001403	ABC transporter signature motif; other site
552531001404	Walker B; other site
552531001405	D-loop; other site
552531001406	H-loop/switch region; other site
552531001407	TOBE domain; Region: TOBE_2; pfam08402
552531001408	Ion transport protein; Region: Ion_trans; pfam00520
552531001409	Ion channel; Region: Ion_trans_2; pfam07885
552531001410	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
552531001411	Catalytic domain of Protein Kinases; Region: PKc; cd00180
552531001412	active site
552531001413	ATP binding site [chemical binding]; other site
552531001414	substrate binding site [chemical binding]; other site
552531001415	activation loop (A-loop); other site
552531001416	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583
552531001417	Domain of unknown function (DUF348); Region: DUF348; pfam03990
552531001418	G5 domain; Region: G5; pfam07501
552531001419	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
552531001420	N-acetyl-D-glucosamine binding site [chemical binding]; other site
552531001421	catalytic residue [active]
552531001422	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
552531001423	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
552531001424	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188
552531001425	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
552531001426	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
552531001427	tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692
552531001428	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
552531001429	active site
552531001430	NTP binding site [chemical binding]; other site
552531001431	metal binding triad [ion binding]; metal-binding site
552531001432	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
552531001433	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552531001434	Zn2+ binding site [ion binding]; other site
552531001435	Mg2+ binding site [ion binding]; other site
552531001436	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
552531001437	active site
552531001438	Ap6A binding site [chemical binding]; other site
552531001439	nudix motif; other site
552531001440	metal binding site [ion binding]; metal-binding site
552531001441	integral membrane protein MviN; Region: mviN; TIGR01695
552531001442	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
552531001443	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
552531001444	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552531001445	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552531001446	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
552531001447	ParB-like nuclease domain; Region: ParB; smart00470
552531001448	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
552531001449	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
552531001450	P-loop; other site
552531001451	Magnesium ion binding site [ion binding]; other site
552531001452	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
552531001453	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
552531001454	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
552531001455	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
552531001456	G-X-X-G motif; other site
552531001457	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
552531001458	RxxxH motif; other site
552531001459	putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315
552531001460	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
552531001461	IncFII RepA protein family; Region: IncFII_repA; cl11495
552531001462	hypothetical protein; Provisional; Region: PRK14372
552531001463	Ribonuclease P; Region: Ribonuclease_P; pfam00825
552531001464	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
552531001465	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086
552531001466	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531001467	Walker A motif; other site
552531001468	ATP binding site [chemical binding]; other site
552531001469	Walker B motif; other site
552531001470	arginine finger; other site
552531001471	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
552531001472	DnaA box-binding interface [nucleotide binding]; other site
552531001473	DNA polymerase III subunit beta; Validated; Region: PRK07761
552531001474	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
552531001475	putative DNA binding surface [nucleotide binding]; other site
552531001476	dimer interface [polypeptide binding]; other site
552531001477	beta-clamp/clamp loader binding surface; other site
552531001478	beta-clamp/translesion DNA polymerase binding surface; other site
552531001479	recombination protein F; Reviewed; Region: recF; PRK00064
552531001480	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001481	Walker A/P-loop; other site
552531001482	ATP binding site [chemical binding]; other site
552531001483	Q-loop/lid; other site
552531001484	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001485	ABC transporter signature motif; other site
552531001486	Walker B; other site
552531001487	D-loop; other site
552531001488	H-loop/switch region; other site
552531001489	Protein of unknown function (DUF721); Region: DUF721; pfam05258
552531001490	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
552531001491	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552531001492	Mg2+ binding site [ion binding]; other site
552531001493	G-X-G motif; other site
552531001494	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
552531001495	anchoring element; other site
552531001496	dimer interface [polypeptide binding]; other site
552531001497	ATP binding site [chemical binding]; other site
552531001498	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
552531001499	active site
552531001500	putative metal-binding site [ion binding]; other site
552531001501	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
552531001502	DNA gyrase subunit A; Validated; Region: PRK05560
552531001503	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
552531001504	CAP-like domain; other site
552531001505	active site
552531001506	primary dimer interface [polypeptide binding]; other site
552531001507	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552531001508	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552531001509	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552531001510	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552531001511	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552531001512	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
552531001513	Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089
552531001514	VanZ like family; Region: VanZ; cl01971
552531001515	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
552531001516	Haemolysin-III related; Region: HlyIII; pfam03006
552531001517	glutamate dehydrogenase; Provisional; Region: PRK09414
552531001518	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
552531001519	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
552531001520	NAD(P) binding site [chemical binding]; other site
552531001521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531001522	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531001523	putative substrate translocation pore; other site
552531001524	Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425
552531001525	Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860
552531001526	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
552531001527	A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448
552531001528	Protein of unknown function DUF45; Region: DUF45; pfam01863
552531001529	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
552531001530	MarR family; Region: MarR_2; pfam12802
552531001531	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
552531001532	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
552531001533	non-specific DNA interactions [nucleotide binding]; other site
552531001534	DNA binding site [nucleotide binding]
552531001535	sequence specific DNA binding site [nucleotide binding]; other site
552531001536	putative cAMP binding site [chemical binding]; other site
552531001537	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
552531001538	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001539	Walker A/P-loop; other site
552531001540	ATP binding site [chemical binding]; other site
552531001541	Q-loop/lid; other site
552531001542	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
552531001543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001544	ABC transporter signature motif; other site
552531001545	Walker B; other site
552531001546	D-loop; other site
552531001547	H-loop/switch region; other site
552531001548	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001549	Walker A/P-loop; other site
552531001550	ATP binding site [chemical binding]; other site
552531001551	Q-loop/lid; other site
552531001552	ABC transporter signature motif; other site
552531001553	Walker B; other site
552531001554	D-loop; other site
552531001555	H-loop/switch region; other site
552531001556	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552531001557	S-adenosylmethionine binding site [chemical binding]; other site
552531001558	Predicted flavoprotein [General function prediction only]; Region: COG0431
552531001559	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
552531001560	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
552531001561	homodimer interface [polypeptide binding]; other site
552531001562	chemical substrate binding site [chemical binding]; other site
552531001563	oligomer interface [polypeptide binding]; other site
552531001564	metal binding site [ion binding]; metal-binding site
552531001565	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
552531001566	GIY-YIG motif/motif A; other site
552531001567	active site
552531001568	catalytic site [active]
552531001569	Helix-turn-helix domain; Region: HTH_17; pfam12728
552531001570	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
552531001571	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
552531001572	cofactor binding site; other site
552531001573	DNA binding site [nucleotide binding]
552531001574	substrate interaction site [chemical binding]; other site
552531001575	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
552531001576	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
552531001577	PemK-like protein; Region: PemK; pfam02452
552531001578	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552531001579	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552531001580	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
552531001581	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552531001582	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552531001583	active site
552531001584	catalytic tetrad [active]
552531001585	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
552531001586	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
552531001587	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
552531001588	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
552531001589	potential frameshift: common BLAST hit: gi|116630082|ref|YP_815254.1| aminoglycoside phosphotransferase
552531001590	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
552531001591	Phosphotransferase enzyme family; Region: APH; pfam01636
552531001592	substrate binding site [chemical binding]; other site
552531001593	Domain of unknown function (DUF4234); Region: DUF4234; pfam14018
552531001594	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
552531001595	Transposase; Region: DDE_Tnp_ISL3; pfam01610
552531001596	O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520
552531001597	O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055
552531001598	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
552531001599	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
552531001600	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
552531001601	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531001602	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531001603	putative substrate translocation pore; other site
552531001604	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552531001605	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552531001606	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
552531001607	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
552531001608	dimerization interface [polypeptide binding]; other site
552531001609	DPS ferroxidase diiron center [ion binding]; other site
552531001610	ion pore; other site
552531001611	Domain of unknown function DUF21; Region: DUF21; pfam01595
552531001612	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
552531001613	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
552531001614	Transporter associated domain; Region: CorC_HlyC; smart01091
552531001615	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
552531001616	active site clefts [active]
552531001617	zinc binding site [ion binding]; other site
552531001618	dimer interface [polypeptide binding]; other site
552531001619	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531001620	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531001621	DNA binding site [nucleotide binding]
552531001622	domain linker motif; other site
552531001623	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
552531001624	ligand binding site [chemical binding]; other site
552531001625	dimerization interface (open form) [polypeptide binding]; other site
552531001626	dimerization interface (closed form) [polypeptide binding]; other site
552531001627	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001628	Walker A/P-loop; other site
552531001629	ATP binding site [chemical binding]; other site
552531001630	ABC transporter; Region: ABC_tran; pfam00005
552531001631	Q-loop/lid; other site
552531001632	ABC transporter signature motif; other site
552531001633	Walker B; other site
552531001634	D-loop; other site
552531001635	H-loop/switch region; other site
552531001636	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531001637	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531001638	DNA binding site [nucleotide binding]
552531001639	domain linker motif; other site
552531001640	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
552531001641	ligand binding site [chemical binding]; other site
552531001642	dimerization interface [polypeptide binding]; other site
552531001643	Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534
552531001644	Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964
552531001645	L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778
552531001646	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
552531001647	putative N- and C-terminal domain interface [polypeptide binding]; other site
552531001648	putative active site [active]
552531001649	MgATP binding site [chemical binding]; other site
552531001650	catalytic site [active]
552531001651	metal binding site [ion binding]; metal-binding site
552531001652	putative carbohydrate binding site [chemical binding]; other site
552531001653	L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557
552531001654	intersubunit interface [polypeptide binding]; other site
552531001655	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
552531001656	active site
552531001657	Zn2+ binding site [ion binding]; other site
552531001658	L-arabinose isomerase; Provisional; Region: PRK02929
552531001659	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947
552531001660	hexamer (dimer of trimers) interface [polypeptide binding]; other site
552531001661	trimer interface [polypeptide binding]; other site
552531001662	substrate binding site [chemical binding]; other site
552531001663	Mn binding site [ion binding]; other site
552531001664	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552531001665	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552531001666	active site
552531001667	catalytic tetrad [active]
552531001668	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
552531001669	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
552531001670	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
552531001671	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
552531001672	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
552531001673	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
552531001674	Transposase; Region: DDE_Tnp_ISL3; pfam01610
552531001675	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
552531001676	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
552531001677	active site
552531001678	HIGH motif; other site
552531001679	dimer interface [polypeptide binding]; other site
552531001680	KMSKS motif; other site
552531001681	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
552531001682	homodimer interface [polypeptide binding]; other site
552531001683	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
552531001684	active site pocket [active]
552531001685	Rhomboid family; Region: Rhomboid; pfam01694
552531001686	Methyltransferase domain; Region: Methyltransf_26; pfam13659
552531001687	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
552531001688	Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830
552531001689	active site
552531001690	catalytic site [active]
552531001691	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
552531001692	Glutamine amidotransferase class-I; Region: GATase; pfam00117
552531001693	glutamine binding [chemical binding]; other site
552531001694	catalytic triad [active]
552531001695	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
552531001696	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
552531001697	active site
552531001698	ATP binding site [chemical binding]; other site
552531001699	substrate binding site [chemical binding]; other site
552531001700	activation loop (A-loop); other site
552531001701	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552531001702	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552531001703	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552531001704	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552531001705	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
552531001706	Catalytic domain of Protein Kinases; Region: PKc; cd00180
552531001707	active site
552531001708	ATP binding site [chemical binding]; other site
552531001709	substrate binding site [chemical binding]; other site
552531001710	activation loop (A-loop); other site
552531001711	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
552531001712	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
552531001713	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
552531001714	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
552531001715	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
552531001716	active site
552531001717	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
552531001718	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
552531001719	phosphopeptide binding site; other site
552531001720	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
552531001721	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
552531001722	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
552531001723	phosphopeptide binding site; other site
552531001724	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
552531001725	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
552531001726	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
552531001727	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
552531001728	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
552531001729	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552531001730	S-adenosylmethionine binding site [chemical binding]; other site
552531001731	Predicted membrane protein [Function unknown]; Region: COG2261
552531001732	ferredoxin-NADP+ reductase; Region: PLN02852
552531001733	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552531001734	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
552531001735	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552531001736	Soluble P-type ATPase [General function prediction only]; Region: COG4087
552531001737	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
552531001738	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
552531001739	protein binding site [polypeptide binding]; other site
552531001740	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
552531001741	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
552531001742	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409
552531001743	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
552531001744	heat shock protein HtpX; Provisional; Region: PRK03072
552531001745	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
552531001746	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
552531001747	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531001748	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531001749	putative substrate translocation pore; other site
552531001750	RelB antitoxin; Region: RelB; cl01171
552531001751	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
552531001752	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
552531001753	DNA binding site [nucleotide binding]
552531001754	active site
552531001755	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
552531001756	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
552531001757	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
552531001758	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
552531001759	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552531001760	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552531001761	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
552531001762	dimerization interface [polypeptide binding]; other site
552531001763	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552531001764	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552531001765	active site
552531001766	catalytic tetrad [active]
552531001767	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
552531001768	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
552531001769	FAD binding pocket [chemical binding]; other site
552531001770	conserved FAD binding motif [chemical binding]; other site
552531001771	phosphate binding motif [ion binding]; other site
552531001772	beta-alpha-beta structure motif; other site
552531001773	NAD binding pocket [chemical binding]; other site
552531001774	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
552531001775	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
552531001776	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
552531001777	NADH(P)-binding; Region: NAD_binding_10; pfam13460
552531001778	NAD(P) binding site [chemical binding]; other site
552531001779	putative active site [active]
552531001780	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
552531001781	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
552531001782	catalytic Zn binding site [ion binding]; other site
552531001783	NAD(P) binding site [chemical binding]; other site
552531001784	structural Zn binding site [ion binding]; other site
552531001785	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552531001786	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552531001787	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
552531001788	dimerization interface [polypeptide binding]; other site
552531001789	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
552531001790	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
552531001791	NodB motif; other site
552531001792	active site
552531001793	catalytic site [active]
552531001794	metal binding site [ion binding]; metal-binding site
552531001795	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
552531001796	Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181
552531001797	active site
552531001798	intersubunit interface [polypeptide binding]; other site
552531001799	zinc binding site [ion binding]; other site
552531001800	Na+ binding site [ion binding]; other site
552531001801	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
552531001802	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
552531001803	GDP-binding site [chemical binding]; other site
552531001804	ACT binding site; other site
552531001805	IMP binding site; other site
552531001806	CrcB-like protein; Region: CRCB; pfam02537
552531001807	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
552531001808	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
552531001809	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
552531001810	TM-ABC transporter signature motif; other site
552531001811	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
552531001812	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
552531001813	TM-ABC transporter signature motif; other site
552531001814	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
552531001815	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
552531001816	Walker A/P-loop; other site
552531001817	ATP binding site [chemical binding]; other site
552531001818	Q-loop/lid; other site
552531001819	ABC transporter signature motif; other site
552531001820	Walker B; other site
552531001821	D-loop; other site
552531001822	H-loop/switch region; other site
552531001823	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
552531001824	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
552531001825	ligand binding site [chemical binding]; other site
552531001826	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531001827	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531001828	DNA binding site [nucleotide binding]
552531001829	domain linker motif; other site
552531001830	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
552531001831	sucrose phosphorylase; Provisional; Region: PRK13840
552531001832	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
552531001833	active site
552531001834	homodimer interface [polypeptide binding]; other site
552531001835	catalytic site [active]
552531001836	Domain of unknown function (DUF1964); Region: DUF1964; pfam09244
552531001837	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531001838	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531001839	putative substrate translocation pore; other site
552531001840	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
552531001841	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
552531001842	ligand binding site [chemical binding]; other site
552531001843	Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439
552531001844	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
552531001845	ATP-grasp domain; Region: ATP-grasp_4; cl17255
552531001846	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
552531001847	Domain of unknown function (DUF4392); Region: DUF4392; pfam14336
552531001848	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
552531001849	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
552531001850	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453
552531001851	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531001852	metabolite-proton symporter; Region: 2A0106; TIGR00883
552531001853	putative substrate translocation pore; other site
552531001854	ketol-acid reductoisomerase; Provisional; Region: PRK05479
552531001855	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
552531001856	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
552531001857	Domain of unknown function (DUF303); Region: DUF303; pfam03629
552531001858	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
552531001859	active site
552531001860	catalytic triad [active]
552531001861	oxyanion hole [active]
552531001862	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
552531001863	beta-galactosidase; Region: BGL; TIGR03356
552531001864	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531001865	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531001866	DNA binding site [nucleotide binding]
552531001867	domain linker motif; other site
552531001868	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
552531001869	ligand binding site [chemical binding]; other site
552531001870	dimerization interface [polypeptide binding]; other site
552531001871	Protein of unknown function, DUF624; Region: DUF624; pfam04854
552531001872	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
552531001873	putative active cleft [active]
552531001874	dimerization interface [polypeptide binding]; other site
552531001875	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
552531001876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001877	Walker A/P-loop; other site
552531001878	ATP binding site [chemical binding]; other site
552531001879	Q-loop/lid; other site
552531001880	ABC transporter signature motif; other site
552531001881	Walker B; other site
552531001882	D-loop; other site
552531001883	H-loop/switch region; other site
552531001884	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
552531001885	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
552531001886	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552531001887	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552531001888	Walker A/P-loop; other site
552531001889	ATP binding site [chemical binding]; other site
552531001890	Q-loop/lid; other site
552531001891	ABC transporter signature motif; other site
552531001892	Walker B; other site
552531001893	D-loop; other site
552531001894	H-loop/switch region; other site
552531001895	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552531001896	FtsX-like permease family; Region: FtsX; pfam02687
552531001897	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
552531001898	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
552531001899	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552531001900	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
552531001901	FtsX-like permease family; Region: FtsX; pfam02687
552531001902	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001903	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552531001904	ABC transporter signature motif; other site
552531001905	Walker B; other site
552531001906	D-loop; other site
552531001907	H-loop/switch region; other site
552531001908	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
552531001909	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552531001910	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552531001911	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001912	Walker A/P-loop; other site
552531001913	ATP binding site [chemical binding]; other site
552531001914	Q-loop/lid; other site
552531001915	ABC transporter signature motif; other site
552531001916	Walker B; other site
552531001917	D-loop; other site
552531001918	H-loop/switch region; other site
552531001919	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
552531001920	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
552531001921	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
552531001922	Walker A/P-loop; other site
552531001923	ATP binding site [chemical binding]; other site
552531001924	Q-loop/lid; other site
552531001925	ABC transporter signature motif; other site
552531001926	Walker B; other site
552531001927	D-loop; other site
552531001928	H-loop/switch region; other site
552531001929	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
552531001930	Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917
552531001931	NodB motif; other site
552531001932	active site
552531001933	catalytic site [active]
552531001934	metal binding site [ion binding]; metal-binding site
552531001935	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
552531001936	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
552531001937	active site
552531001938	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
552531001939	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
552531001940	active site
552531001941	substrate binding site [chemical binding]; other site
552531001942	trimer interface [polypeptide binding]; other site
552531001943	CoA binding site [chemical binding]; other site
552531001944	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
552531001945	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
552531001946	ligand binding site [chemical binding]; other site
552531001947	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552531001948	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552531001949	Predicted membrane protein [Function unknown]; Region: COG1511
552531001950	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
552531001951	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
552531001952	Predicted membrane protein [Function unknown]; Region: COG1511
552531001953	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
552531001954	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
552531001955	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
552531001956	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
552531001957	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
552531001958	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552531001959	Walker A/P-loop; other site
552531001960	ATP binding site [chemical binding]; other site
552531001961	Q-loop/lid; other site
552531001962	ABC transporter signature motif; other site
552531001963	Walker B; other site
552531001964	D-loop; other site
552531001965	H-loop/switch region; other site
552531001966	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531001967	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
552531001968	Walker A/P-loop; other site
552531001969	ATP binding site [chemical binding]; other site
552531001970	Q-loop/lid; other site
552531001971	ABC transporter signature motif; other site
552531001972	Walker B; other site
552531001973	D-loop; other site
552531001974	H-loop/switch region; other site
552531001975	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
552531001976	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
552531001977	active site
552531001978	nucleophile elbow; other site
552531001979	Peptidase family C69; Region: Peptidase_C69; pfam03577
552531001980	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552531001981	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552531001982	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
552531001983	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
552531001984	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
552531001985	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
552531001986	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
552531001987	Nitrogen regulatory protein P-II; Region: P-II; smart00938
552531001988	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
552531001989	metal binding triad; other site
552531001990	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
552531001991	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
552531001992	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552531001993	sequence-specific DNA binding site [nucleotide binding]; other site
552531001994	salt bridge; other site
552531001995	replicative DNA helicase; Region: DnaB; TIGR00665
552531001996	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
552531001997	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
552531001998	Walker A motif; other site
552531001999	ATP binding site [chemical binding]; other site
552531002000	Walker B motif; other site
552531002001	DNA binding loops [nucleotide binding]
552531002002	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
552531002003	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
552531002004	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
552531002005	catalytic triad [active]
552531002006	Uncharacterized conserved protein [Function unknown]; Region: COG3937
552531002007	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
552531002008	ABC1 family; Region: ABC1; cl17513
552531002009	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
552531002010	active site
552531002011	catalytic site [active]
552531002012	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
552531002013	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552531002014	active site
552531002015	Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673
552531002016	active site
552531002017	Ap6A binding site [chemical binding]; other site
552531002018	nudix motif; other site
552531002019	metal binding site [ion binding]; metal-binding site
552531002020	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531002021	catalytic core [active]
552531002022	polyphosphate kinase; Provisional; Region: PRK05443
552531002023	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
552531002024	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
552531002025	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
552531002026	putative domain interface [polypeptide binding]; other site
552531002027	putative active site [active]
552531002028	catalytic site [active]
552531002029	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
552531002030	putative domain interface [polypeptide binding]; other site
552531002031	putative active site [active]
552531002032	catalytic site [active]
552531002033	Type II/IV secretion system protein; Region: T2SE; pfam00437
552531002034	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
552531002035	Walker B motif; other site
552531002036	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
552531002037	Protein of unknown function (DUF4244); Region: DUF4244; pfam14029
552531002038	TadE-like protein; Region: TadE; pfam07811
552531002039	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764
552531002040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531002041	Walker A motif; other site
552531002042	ATP binding site [chemical binding]; other site
552531002043	Walker B motif; other site
552531002044	arginine finger; other site
552531002045	recombination protein RecR; Reviewed; Region: recR; PRK00076
552531002046	RecR protein; Region: RecR; pfam02132
552531002047	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
552531002048	putative active site [active]
552531002049	putative metal-binding site [ion binding]; other site
552531002050	tetramer interface [polypeptide binding]; other site
552531002051	aspartate kinase; Reviewed; Region: PRK06635
552531002052	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
552531002053	putative nucleotide binding site [chemical binding]; other site
552531002054	putative catalytic residues [active]
552531002055	putative Mg ion binding site [ion binding]; other site
552531002056	putative aspartate binding site [chemical binding]; other site
552531002057	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
552531002058	putative allosteric regulatory site; other site
552531002059	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
552531002060	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
552531002061	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
552531002062	2-isopropylmalate synthase; Validated; Region: PRK03739
552531002063	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
552531002064	active site
552531002065	catalytic residues [active]
552531002066	metal binding site [ion binding]; metal-binding site
552531002067	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
552531002068	Transglycosylase; Region: Transgly; pfam00912
552531002069	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
552531002070	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
552531002071	Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260
552531002072	Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554
552531002073	PAP2 superfamily; Region: PAP2; pfam01569
552531002074	active site
552531002075	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
552531002076	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
552531002077	active site
552531002078	interdomain interaction site; other site
552531002079	putative metal-binding site [ion binding]; other site
552531002080	nucleotide binding site [chemical binding]; other site
552531002081	Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436
552531002082	domain I; other site
552531002083	phosphate binding site [ion binding]; other site
552531002084	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
552531002085	domain II; other site
552531002086	domain III; other site
552531002087	nucleotide binding site [chemical binding]; other site
552531002088	DNA binding groove [nucleotide binding]
552531002089	catalytic site [active]
552531002090	domain IV; other site
552531002091	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
552531002092	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
552531002093	thymidylate kinase; Validated; Region: tmk; PRK00698
552531002094	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
552531002095	TMP-binding site; other site
552531002096	ATP-binding site [chemical binding]; other site
552531002097	DNA polymerase III subunit delta'; Validated; Region: PRK07940
552531002098	DNA polymerase III subunit delta'; Validated; Region: PRK08485
552531002099	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
552531002100	substrate binding site [chemical binding]; other site
552531002101	Peptidase family C69; Region: Peptidase_C69; pfam03577
552531002102	Peptidase family C69; Region: Peptidase_C69; pfam03577
552531002103	AAA domain; Region: AAA_14; pfam13173
552531002104	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
552531002105	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
552531002106	macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450
552531002107	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
552531002108	putative active site [active]
552531002109	Predicted membrane protein [Function unknown]; Region: COG2246
552531002110	GtrA-like protein; Region: GtrA; pfam04138
552531002111	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531002112	catalytic core [active]
552531002113	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531002114	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531002115	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
552531002116	Transposase; Region: DDE_Tnp_ISL3; pfam01610
552531002117	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
552531002118	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
552531002119	active site
552531002120	HIGH motif; other site
552531002121	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
552531002122	active site
552531002123	KMSKS motif; other site
552531002124	Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383
552531002125	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
552531002126	putative active site [active]
552531002127	putative metal binding site [ion binding]; other site
552531002128	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
552531002129	Transcriptional regulator [Transcription]; Region: IclR; COG1414
552531002130	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
552531002131	Bacterial transcriptional regulator; Region: IclR; pfam01614
552531002132	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
552531002133	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
552531002134	substrate binding site [chemical binding]; other site
552531002135	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
552531002136	AsnC family; Region: AsnC_trans_reg; pfam01037
552531002137	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
552531002138	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552531002139	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552531002140	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
552531002141	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
552531002142	ATP-grasp domain; Region: ATP-grasp_4; cl17255
552531002143	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
552531002144	CAAX protease self-immunity; Region: Abi; pfam02517
552531002145	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
552531002146	Mechanosensitive ion channel; Region: MS_channel; pfam00924
552531002147	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552531002148	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
552531002149	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
552531002150	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
552531002151	nucleophilic elbow; other site
552531002152	catalytic triad; other site
552531002153	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
552531002154	Predicted membrane protein [Function unknown]; Region: COG4905
552531002155	aspartate aminotransferase; Provisional; Region: PRK06836
552531002156	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531002157	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531002158	homodimer interface [polypeptide binding]; other site
552531002159	catalytic residue [active]
552531002160	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
552531002161	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
552531002162	binding surface
552531002163	TPR motif; other site
552531002164	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
552531002165	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
552531002166	substrate binding site [chemical binding]; other site
552531002167	ATP binding site [chemical binding]; other site
552531002168	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
552531002169	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
552531002170	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
552531002171	ssDNA binding site; other site
552531002172	generic binding surface II; other site
552531002173	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552531002174	ATP binding site [chemical binding]; other site
552531002175	putative Mg++ binding site [ion binding]; other site
552531002176	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531002177	nucleotide binding region [chemical binding]; other site
552531002178	ATP-binding site [chemical binding]; other site
552531002179	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
552531002180	metal ion-dependent adhesion site (MIDAS); other site
552531002181	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
552531002182	T surface-antigen of pili; Region: FctA; pfam12892
552531002183	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
552531002184	T surface-antigen of pili; Region: FctA; pfam12892
552531002185	T surface-antigen of pili; Region: FctA; pfam12892
552531002186	T surface-antigen of pili; Region: FctA; pfam12892
552531002187	T surface-antigen of pili; Region: FctA; pfam12892
552531002188	T surface-antigen of pili; Region: FctA; pfam12892
552531002189	T surface-antigen of pili; Region: FctA; pfam12892
552531002190	T surface-antigen of pili; Region: FctA; pfam12892
552531002191	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
552531002192	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
552531002193	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552531002194	S-adenosylmethionine binding site [chemical binding]; other site
552531002195	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
552531002196	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
552531002197	RimM N-terminal domain; Region: RimM; pfam01782
552531002198	PRC-barrel domain; Region: PRC; pfam05239
552531002199	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
552531002200	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
552531002201	G-X-X-G motif; other site
552531002202	30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520
552531002203	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
552531002204	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
552531002205	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
552531002206	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
552531002207	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
552531002208	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
552531002209	putative catalytic site [active]
552531002210	putative metal binding site [ion binding]; other site
552531002211	putative phosphate binding site [ion binding]; other site
552531002212	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
552531002213	putative catalytic site [active]
552531002214	putative phosphate binding site [ion binding]; other site
552531002215	putative metal binding site [ion binding]; other site
552531002216	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
552531002217	Cation efflux family; Region: Cation_efflux; pfam01545
552531002218	signal recognition particle protein; Provisional; Region: PRK10867
552531002219	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
552531002220	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
552531002221	P loop; other site
552531002222	GTP binding site [chemical binding]; other site
552531002223	Signal peptide binding domain; Region: SRP_SPB; pfam02978
552531002224	Protein involved in chromosome segregation, interacts with SMC proteins [Cell division and chromosome partitioning]; Region: HEC1; COG5185
552531002225	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
552531002226	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
552531002227	active site
552531002228	HIGH motif; other site
552531002229	nucleotide binding site [chemical binding]; other site
552531002230	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
552531002231	KMSKS motif; other site
552531002232	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
552531002233	tRNA binding surface [nucleotide binding]; other site
552531002234	anticodon binding site; other site
552531002235	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552531002236	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552531002237	ABC transporter; Region: ABC_tran_2; pfam12848
552531002238	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552531002239	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
552531002240	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
552531002241	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
552531002242	catalytic triad [active]
552531002243	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
552531002244	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
552531002245	putative valine binding site [chemical binding]; other site
552531002246	dimer interface [polypeptide binding]; other site
552531002247	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
552531002248	acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789
552531002249	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
552531002250	PYR/PP interface [polypeptide binding]; other site
552531002251	dimer interface [polypeptide binding]; other site
552531002252	TPP binding site [chemical binding]; other site
552531002253	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
552531002254	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
552531002255	TPP-binding site [chemical binding]; other site
552531002256	dimer interface [polypeptide binding]; other site
552531002257	ribonuclease III; Reviewed; Region: rnc; PRK00102
552531002258	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
552531002259	dimerization interface [polypeptide binding]; other site
552531002260	active site
552531002261	metal binding site [ion binding]; metal-binding site
552531002262	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
552531002263	dsRNA binding site [nucleotide binding]; other site
552531002264	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
552531002265	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
552531002266	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
552531002267	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
552531002268	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
552531002269	active site
552531002270	(T/H)XGH motif; other site
552531002271	Protein of unknown function (DUF3039); Region: DUF3039; pfam11238
552531002272	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552531002273	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552531002274	active site
552531002275	catalytic tetrad [active]
552531002276	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
552531002277	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
552531002278	active site
552531002279	ribonuclease PH; Reviewed; Region: rph; PRK00173
552531002280	Ribonuclease PH; Region: RNase_PH_bact; cd11362
552531002281	hexamer interface [polypeptide binding]; other site
552531002282	active site
552531002283	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
552531002284	active site
552531002285	dimerization interface [polypeptide binding]; other site
552531002286	FemAB family; Region: FemAB; pfam02388
552531002287	Membrane transport protein; Region: Mem_trans; cl09117
552531002288	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
552531002289	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
552531002290	Substrate binding site; other site
552531002291	Cupin domain; Region: Cupin_2; cl17218
552531002292	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
552531002293	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
552531002294	active site
552531002295	dimer interface [polypeptide binding]; other site
552531002296	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
552531002297	dimer interface [polypeptide binding]; other site
552531002298	active site
552531002299	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
552531002300	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
552531002301	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
552531002302	Catalytic site [active]
552531002303	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
552531002304	RNA/DNA hybrid binding site [nucleotide binding]; other site
552531002305	active site
552531002306	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
552531002307	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552531002308	Walker A/P-loop; other site
552531002309	ATP binding site [chemical binding]; other site
552531002310	Q-loop/lid; other site
552531002311	ABC transporter signature motif; other site
552531002312	Walker B; other site
552531002313	D-loop; other site
552531002314	H-loop/switch region; other site
552531002315	FtsX-like permease family; Region: FtsX; pfam02687
552531002316	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007
552531002317	M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647
552531002318	metal binding site [ion binding]; metal-binding site
552531002319	putative dimer interface [polypeptide binding]; other site
552531002320	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
552531002321	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
552531002322	homodimer interface [polypeptide binding]; other site
552531002323	oligonucleotide binding site [chemical binding]; other site
552531002324	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
552531002325	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
552531002326	gamma-glutamyl kinase; Provisional; Region: PRK05429
552531002327	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
552531002328	nucleotide binding site [chemical binding]; other site
552531002329	homotetrameric interface [polypeptide binding]; other site
552531002330	putative phosphate binding site [ion binding]; other site
552531002331	putative allosteric binding site; other site
552531002332	PUA domain; Region: PUA; pfam01472
552531002333	aspartate aminotransferase; Provisional; Region: PRK05764
552531002334	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531002335	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531002336	homodimer interface [polypeptide binding]; other site
552531002337	catalytic residue [active]
552531002338	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
552531002339	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
552531002340	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
552531002341	putative homodimer interface [polypeptide binding]; other site
552531002342	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
552531002343	heterodimer interface [polypeptide binding]; other site
552531002344	homodimer interface [polypeptide binding]; other site
552531002345	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
552531002346	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
552531002347	23S rRNA interface [nucleotide binding]; other site
552531002348	L7/L12 interface [polypeptide binding]; other site
552531002349	putative thiostrepton binding site; other site
552531002350	L25 interface [polypeptide binding]; other site
552531002351	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
552531002352	mRNA/rRNA interface [nucleotide binding]; other site
552531002353	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
552531002354	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
552531002355	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
552531002356	BioY family; Region: BioY; pfam02632
552531002357	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
552531002358	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
552531002359	ATP-grasp domain; Region: ATP-grasp_4; cl17255
552531002360	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785
552531002361	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
552531002362	carboxyltransferase (CT) interaction site; other site
552531002363	biotinylation site [posttranslational modification]; other site
552531002364	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
552531002365	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
552531002366	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
552531002367	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
552531002368	Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981
552531002369	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
552531002370	FMN binding site [chemical binding]; other site
552531002371	substrate binding site [chemical binding]; other site
552531002372	putative catalytic residue [active]
552531002373	Domain of unknown function (DUF1729); Region: DUF1729; pfam08354
552531002374	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
552531002375	active site 2 [active]
552531002376	active site 1 [active]
552531002377	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
552531002378	3-oxoacyl-[acyl-carrier protein]; Region: COG4982
552531002379	ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950
552531002380	putative NAD(P) binding site [chemical binding]; other site
552531002381	active site
552531002382	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
552531002383	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
552531002384	active site
552531002385	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
552531002386	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
552531002387	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
552531002388	NAD binding site [chemical binding]; other site
552531002389	dimer interface [polypeptide binding]; other site
552531002390	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552531002391	substrate binding site [chemical binding]; other site
552531002392	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
552531002393	16S/18S rRNA binding site [nucleotide binding]; other site
552531002394	S13e-L30e interaction site [polypeptide binding]; other site
552531002395	25S rRNA binding site [nucleotide binding]; other site
552531002396	guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696
552531002397	RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114
552531002398	oligomer interface [polypeptide binding]; other site
552531002399	RNA binding site [nucleotide binding]; other site
552531002400	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
552531002401	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
552531002402	RNase E interface [polypeptide binding]; other site
552531002403	trimer interface [polypeptide binding]; other site
552531002404	active site
552531002405	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
552531002406	putative nucleic acid binding region [nucleotide binding]; other site
552531002407	G-X-X-G motif; other site
552531002408	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
552531002409	RNA binding site [nucleotide binding]; other site
552531002410	domain interface; other site
552531002411	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
552531002412	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
552531002413	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
552531002414	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
552531002415	dimer interface [polypeptide binding]; other site
552531002416	putative radical transfer pathway; other site
552531002417	diiron center [ion binding]; other site
552531002418	tyrosyl radical; other site
552531002419	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188
552531002420	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
552531002421	Class I ribonucleotide reductase; Region: RNR_I; cd01679
552531002422	active site
552531002423	dimer interface [polypeptide binding]; other site
552531002424	catalytic residues [active]
552531002425	effector binding site; other site
552531002426	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
552531002427	ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600
552531002428	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552531002429	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552531002430	active site
552531002431	catalytic tetrad [active]
552531002432	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
552531002433	Peptidase family U32; Region: Peptidase_U32; pfam01136
552531002434	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
552531002435	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
552531002436	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
552531002437	substrate binding site; other site
552531002438	dimer interface; other site
552531002439	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
552531002440	putative substrate binding pocket [chemical binding]; other site
552531002441	AC domain interface; other site
552531002442	catalytic triad [active]
552531002443	AB domain interface; other site
552531002444	interchain disulfide; other site
552531002445	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
552531002446	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
552531002447	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
552531002448	trimer interface [polypeptide binding]; other site
552531002449	active site
552531002450	G bulge; other site
552531002451	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
552531002452	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
552531002453	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
552531002454	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
552531002455	catalytic triad [active]
552531002456	catalytic triad [active]
552531002457	oxyanion hole [active]
552531002458	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
552531002459	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
552531002460	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
552531002461	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
552531002462	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
552531002463	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552531002464	dimer interface [polypeptide binding]; other site
552531002465	phosphorylation site [posttranslational modification]
552531002466	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552531002467	ATP binding site [chemical binding]; other site
552531002468	Mg2+ binding site [ion binding]; other site
552531002469	G-X-G motif; other site
552531002470	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552531002471	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552531002472	active site
552531002473	phosphorylation site [posttranslational modification]
552531002474	intermolecular recognition site; other site
552531002475	dimerization interface [polypeptide binding]; other site
552531002476	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552531002477	DNA binding site [nucleotide binding]
552531002478	PBP superfamily domain; Region: PBP_like_2; cl17296
552531002479	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
552531002480	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531002481	dimer interface [polypeptide binding]; other site
552531002482	conserved gate region; other site
552531002483	putative PBP binding loops; other site
552531002484	ABC-ATPase subunit interface; other site
552531002485	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
552531002486	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531002487	dimer interface [polypeptide binding]; other site
552531002488	conserved gate region; other site
552531002489	putative PBP binding loops; other site
552531002490	ABC-ATPase subunit interface; other site
552531002491	phosphate transporter ATP-binding protein; Provisional; Region: PRK14241
552531002492	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
552531002493	Walker A/P-loop; other site
552531002494	ATP binding site [chemical binding]; other site
552531002495	Q-loop/lid; other site
552531002496	ABC transporter signature motif; other site
552531002497	Walker B; other site
552531002498	D-loop; other site
552531002499	H-loop/switch region; other site
552531002500	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
552531002501	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
552531002502	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
552531002503	intersubunit interface [polypeptide binding]; other site
552531002504	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
552531002505	23S rRNA interface [nucleotide binding]; other site
552531002506	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
552531002507	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
552531002508	peripheral dimer interface [polypeptide binding]; other site
552531002509	core dimer interface [polypeptide binding]; other site
552531002510	L10 interface [polypeptide binding]; other site
552531002511	L11 interface [polypeptide binding]; other site
552531002512	putative EF-Tu interaction site [polypeptide binding]; other site
552531002513	putative EF-G interaction site [polypeptide binding]; other site
552531002514	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
552531002515	phosphopeptide binding site; other site
552531002516	Part of AAA domain; Region: AAA_19; pfam13245
552531002517	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
552531002518	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
552531002519	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
552531002520	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
552531002521	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
552531002522	oligomerisation interface [polypeptide binding]; other site
552531002523	mobile loop; other site
552531002524	roof hairpin; other site
552531002525	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
552531002526	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903
552531002527	FAD binding domain; Region: FAD_binding_4; pfam01565
552531002528	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
552531002529	amino acid transporter; Region: 2A0306; TIGR00909
552531002530	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
552531002531	Ferredoxin [Energy production and conversion]; Region: COG1146
552531002532	4Fe-4S binding domain; Region: Fer4; pfam00037
552531002533	N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865
552531002534	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531002535	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531002536	homodimer interface [polypeptide binding]; other site
552531002537	catalytic residue [active]
552531002538	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
552531002539	active site
552531002540	DNA polymerase IV; Validated; Region: PRK02406
552531002541	DNA binding site [nucleotide binding]
552531002542	Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169
552531002543	dimerization interface [polypeptide binding]; other site
552531002544	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
552531002545	NAD binding site [chemical binding]; other site
552531002546	ligand binding site [chemical binding]; other site
552531002547	catalytic site [active]
552531002548	Uncharacterized conserved protein [Function unknown]; Region: COG1739
552531002549	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
552531002550	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
552531002551	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
552531002552	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
552531002553	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
552531002554	23S rRNA interface [nucleotide binding]; other site
552531002555	L3 interface [polypeptide binding]; other site
552531002556	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
552531002557	pullulanase, type I; Region: pulA_typeI; TIGR02104
552531002558	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
552531002559	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
552531002560	active site
552531002561	catalytic site [active]
552531002562	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
552531002563	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552531002564	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
552531002565	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
552531002566	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
552531002567	putative catalytic cysteine [active]
552531002568	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
552531002569	putative active site [active]
552531002570	metal binding site [ion binding]; metal-binding site
552531002571	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
552531002572	YwiC-like protein; Region: YwiC; pfam14256
552531002573	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
552531002574	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
552531002575	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
552531002576	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
552531002577	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
552531002578	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
552531002579	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
552531002580	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
552531002581	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
552531002582	putative translocon binding site; other site
552531002583	protein-rRNA interface [nucleotide binding]; other site
552531002584	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
552531002585	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
552531002586	G-X-X-G motif; other site
552531002587	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
552531002588	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
552531002589	23S rRNA interface [nucleotide binding]; other site
552531002590	5S rRNA interface [nucleotide binding]; other site
552531002591	putative antibiotic binding site [chemical binding]; other site
552531002592	L25 interface [polypeptide binding]; other site
552531002593	L27 interface [polypeptide binding]; other site
552531002594	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
552531002595	23S rRNA interface [nucleotide binding]; other site
552531002596	putative translocon interaction site; other site
552531002597	signal recognition particle (SRP54) interaction site; other site
552531002598	L23 interface [polypeptide binding]; other site
552531002599	trigger factor interaction site; other site
552531002600	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
552531002601	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
552531002602	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
552531002603	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
552531002604	RNA binding site [nucleotide binding]; other site
552531002605	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
552531002606	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
552531002607	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
552531002608	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
552531002609	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
552531002610	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
552531002611	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
552531002612	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
552531002613	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
552531002614	23S rRNA interface [nucleotide binding]; other site
552531002615	L21e interface [polypeptide binding]; other site
552531002616	5S rRNA interface [nucleotide binding]; other site
552531002617	L27 interface [polypeptide binding]; other site
552531002618	L5 interface [polypeptide binding]; other site
552531002619	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
552531002620	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
552531002621	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
552531002622	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
552531002623	23S rRNA binding site [nucleotide binding]; other site
552531002624	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
552531002625	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
552531002626	SecY translocase; Region: SecY; pfam00344
552531002627	adenylate kinase; Reviewed; Region: adk; PRK00279
552531002628	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
552531002629	AMP-binding site [chemical binding]; other site
552531002630	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
552531002631	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
552531002632	rRNA binding site [nucleotide binding]; other site
552531002633	predicted 30S ribosome binding site; other site
552531002634	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
552531002635	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
552531002636	30S ribosomal protein S13; Region: bact_S13; TIGR03631
552531002637	30S ribosomal protein S11; Validated; Region: PRK05309
552531002638	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
552531002639	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
552531002640	alphaNTD homodimer interface [polypeptide binding]; other site
552531002641	alphaNTD - beta interaction site [polypeptide binding]; other site
552531002642	alphaNTD - beta' interaction site [polypeptide binding]; other site
552531002643	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
552531002644	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
552531002645	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
552531002646	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
552531002647	dimerization interface 3.5A [polypeptide binding]; other site
552531002648	active site
552531002649	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
552531002650	NusA N-terminal domain; Region: NusA_N; pfam08529
552531002651	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
552531002652	RNA binding site [nucleotide binding]; other site
552531002653	homodimer interface [polypeptide binding]; other site
552531002654	NusA-like KH domain; Region: KH_5; pfam13184
552531002655	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
552531002656	G-X-X-G motif; other site
552531002657	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
552531002658	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
552531002659	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
552531002660	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
552531002661	G1 box; other site
552531002662	putative GEF interaction site [polypeptide binding]; other site
552531002663	GTP/Mg2+ binding site [chemical binding]; other site
552531002664	Switch I region; other site
552531002665	G2 box; other site
552531002666	G3 box; other site
552531002667	Switch II region; other site
552531002668	G4 box; other site
552531002669	G5 box; other site
552531002670	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
552531002671	Translation-initiation factor 2; Region: IF-2; pfam11987
552531002672	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
552531002673	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
552531002674	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287
552531002675	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
552531002676	RNA binding site [nucleotide binding]; other site
552531002677	active site
552531002678	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
552531002679	FAD synthetase; Region: FAD_syn; pfam06574
552531002680	active site
552531002681	nucleotide binding site [chemical binding]; other site
552531002682	HIGH motif; other site
552531002683	KMSKS motif; other site
552531002684	Riboflavin kinase; Region: Flavokinase; smart00904
552531002685	DNA repair protein RadA; Provisional; Region: PRK11823
552531002686	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
552531002687	Walker A motif; other site
552531002688	ATP binding site [chemical binding]; other site
552531002689	Walker B motif; other site
552531002690	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
552531002691	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
552531002692	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552531002693	active site
552531002694	dimer interface [polypeptide binding]; other site
552531002695	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
552531002696	RNA/DNA hybrid binding site [nucleotide binding]; other site
552531002697	active site
552531002698	seryl-tRNA synthetase; Provisional; Region: PRK05431
552531002699	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
552531002700	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
552531002701	dimer interface [polypeptide binding]; other site
552531002702	active site
552531002703	motif 1; other site
552531002704	motif 2; other site
552531002705	motif 3; other site
552531002706	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
552531002707	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
552531002708	phosphoglucomutase; Validated; Region: PRK07564
552531002709	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
552531002710	active site
552531002711	substrate binding site [chemical binding]; other site
552531002712	metal binding site [ion binding]; metal-binding site
552531002713	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
552531002714	Protein of unknown function (DUF4125); Region: DUF4125; pfam13526
552531002715	Tetratricopeptide repeat; Region: TPR_12; pfam13424
552531002716	Tetratricopeptide repeat; Region: TPR_12; pfam13424
552531002717	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
552531002718	binding surface
552531002719	TPR motif; other site
552531002720	Domain of unknown function (DUF4037); Region: DUF4037; pfam13228
552531002721	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
552531002722	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552531002723	active site
552531002724	phosphorylation site [posttranslational modification]
552531002725	intermolecular recognition site; other site
552531002726	dimerization interface [polypeptide binding]; other site
552531002727	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
552531002728	DNA binding residues [nucleotide binding]
552531002729	dimerization interface [polypeptide binding]; other site
552531002730	PspC domain; Region: PspC; pfam04024
552531002731	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
552531002732	PspC domain; Region: PspC; pfam04024
552531002733	IncA protein; Region: IncA; pfam04156
552531002734	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
552531002735	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
552531002736	homodimer interface [polypeptide binding]; other site
552531002737	substrate-cofactor binding pocket; other site
552531002738	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531002739	catalytic residue [active]
552531002740	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
552531002741	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
552531002742	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552531002743	catalytic residue [active]
552531002744	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
552531002745	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
552531002746	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
552531002747	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
552531002748	dimer interface [polypeptide binding]; other site
552531002749	putative anticodon binding site; other site
552531002750	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
552531002751	motif 1; other site
552531002752	dimer interface [polypeptide binding]; other site
552531002753	active site
552531002754	motif 2; other site
552531002755	motif 3; other site
552531002756	Phospholipase B; Region: Phospholip_B; pfam04916
552531002757	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
552531002758	trimer interface [polypeptide binding]; other site
552531002759	active site
552531002760	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
552531002761	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
552531002762	Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939
552531002763	Serine carboxypeptidase; Region: Peptidase_S10; cl08270
552531002764	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
552531002765	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
552531002766	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531002767	catalytic core [active]
552531002768	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531002769	myosin-cross-reactive antigen; Provisional; Region: PRK13977
552531002770	potential frameshift: common BLAST hit: gi|148544876|ref|YP_001272246.1| alcohol dehydrogenase
552531002771	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
552531002772	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
552531002773	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
552531002774	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
552531002775	NAD(P) binding site [chemical binding]; other site
552531002776	mannose-6-phosphate isomerase; Region: PLN02288
552531002777	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
552531002778	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
552531002779	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
552531002780	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552531002781	ATP binding site [chemical binding]; other site
552531002782	Mg2+ binding site [ion binding]; other site
552531002783	G-X-G motif; other site
552531002784	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
552531002785	PhoU domain; Region: PhoU; pfam01895
552531002786	PhoU domain; Region: PhoU; pfam01895
552531002787	phosphoserine aminotransferase; Provisional; Region: PRK03080
552531002788	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552531002789	catalytic residue [active]
552531002790	CHAP domain; Region: CHAP; pfam05257
552531002791	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
552531002792	NlpC/P60 family; Region: NLPC_P60; cl17555
552531002793	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
552531002794	Ligand Binding Site [chemical binding]; other site
552531002795	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
552531002796	Ligand Binding Site [chemical binding]; other site
552531002797	OsmC-like protein; Region: OsmC; cl00767
552531002798	thymidylate synthase; Reviewed; Region: thyA; PRK01827
552531002799	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
552531002800	dimerization interface [polypeptide binding]; other site
552531002801	active site
552531002802	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
552531002803	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
552531002804	folate binding site [chemical binding]; other site
552531002805	NADP+ binding site [chemical binding]; other site
552531002806	Low molecular weight phosphatase family; Region: LMWPc; cd00115
552531002807	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
552531002808	active site
552531002809	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
552531002810	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
552531002811	NAD(P) binding site [chemical binding]; other site
552531002812	active site
552531002813	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
552531002814	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
552531002815	putative active site [active]
552531002816	5'-nucleotidase; Region: 5-nucleotidase; pfam06189
552531002817	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
552531002818	serine/threonine protein kinase; Provisional; Region: PRK14879
552531002819	AAA domain; Region: AAA_21; pfam13304
552531002820	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
552531002821	putative active site [active]
552531002822	putative metal-binding site [ion binding]; other site
552531002823	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
552531002824	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
552531002825	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
552531002826	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
552531002827	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
552531002828	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
552531002829	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
552531002830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
552531002831	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
552531002832	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
552531002833	Uncharacterized conserved protein [Function unknown]; Region: COG3189
552531002834	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
552531002835	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
552531002836	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
552531002837	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
552531002838	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
552531002839	Beta galactosidase small chain; Region: Bgal_small_N; cl03787
552531002840	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531002841	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531002842	DNA binding site [nucleotide binding]
552531002843	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
552531002844	putative dimerization interface [polypeptide binding]; other site
552531002845	putative ligand binding site [chemical binding]; other site
552531002846	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
552531002847	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531002848	motif II; other site
552531002849	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
552531002850	Domain of unknown function (DUF4190); Region: DUF4190; pfam13828
552531002851	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
552531002852	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
552531002853	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
552531002854	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
552531002855	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552531002856	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531002857	dimer interface [polypeptide binding]; other site
552531002858	conserved gate region; other site
552531002859	putative PBP binding loops; other site
552531002860	ABC-ATPase subunit interface; other site
552531002861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531002862	dimer interface [polypeptide binding]; other site
552531002863	conserved gate region; other site
552531002864	putative PBP binding loops; other site
552531002865	ABC-ATPase subunit interface; other site
552531002866	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531002867	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531002868	DNA binding site [nucleotide binding]
552531002869	domain linker motif; other site
552531002870	Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574
552531002871	ligand binding site [chemical binding]; other site
552531002872	dimerization interface (open form) [polypeptide binding]; other site
552531002873	dimerization interface (closed form) [polypeptide binding]; other site
552531002874	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
552531002875	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
552531002876	active site
552531002877	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
552531002878	Domain of unknown function DUF20; Region: UPF0118; pfam01594
552531002879	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
552531002880	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
552531002881	DXD motif; other site
552531002882	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
552531002883	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
552531002884	Walker A/P-loop; other site
552531002885	ATP binding site [chemical binding]; other site
552531002886	Q-loop/lid; other site
552531002887	ABC transporter signature motif; other site
552531002888	Walker B; other site
552531002889	D-loop; other site
552531002890	H-loop/switch region; other site
552531002891	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
552531002892	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
552531002893	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
552531002894	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
552531002895	Ligand Binding Site [chemical binding]; other site
552531002896	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552531002897	active site
552531002898	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
552531002899	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531002900	Walker A motif; other site
552531002901	ATP binding site [chemical binding]; other site
552531002902	Walker B motif; other site
552531002903	arginine finger; other site
552531002904	Peptidase family M41; Region: Peptidase_M41; pfam01434
552531002905	Protein of unknown function (DUF3180); Region: DUF3180; pfam11377
552531002906	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
552531002907	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
552531002908	active site
552531002909	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
552531002910	catalytic triad [active]
552531002911	dimer interface [polypeptide binding]; other site
552531002912	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
552531002913	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552531002914	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552531002915	ABC transporter; Region: ABC_tran_2; pfam12848
552531002916	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552531002917	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
552531002918	active site
552531002919	catalytic residues [active]
552531002920	metal binding site [ion binding]; metal-binding site
552531002921	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
552531002922	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
552531002923	homodimer interface [polypeptide binding]; other site
552531002924	substrate-cofactor binding pocket; other site
552531002925	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531002926	catalytic residue [active]
552531002927	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
552531002928	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
552531002929	xylose isomerase; Provisional; Region: PRK05474
552531002930	xylose isomerase; Region: xylose_isom_A; TIGR02630
552531002931	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
552531002932	active site
552531002933	Transcriptional regulators [Transcription]; Region: PurR; COG1609
552531002934	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
552531002935	DNA binding site [nucleotide binding]
552531002936	Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296
552531002937	putative ligand binding site [chemical binding]; other site
552531002938	putative dimerization interface [polypeptide binding]; other site
552531002939	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
552531002940	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
552531002941	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
552531002942	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531002943	dimer interface [polypeptide binding]; other site
552531002944	conserved gate region; other site
552531002945	putative PBP binding loops; other site
552531002946	ABC-ATPase subunit interface; other site
552531002947	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
552531002948	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531002949	dimer interface [polypeptide binding]; other site
552531002950	conserved gate region; other site
552531002951	putative PBP binding loops; other site
552531002952	ABC-ATPase subunit interface; other site
552531002953	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
552531002954	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
552531002955	inhibitor binding site; inhibition site
552531002956	active site
552531002957	Domain of unknown function (DUF303); Region: DUF303; pfam03629
552531002958	Domain of unknown function (DUF303); Region: DUF303; pfam03629
552531002959	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
552531002960	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
552531002961	substrate binding pocket [chemical binding]; other site
552531002962	catalytic triad [active]
552531002963	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
552531002964	Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507
552531002965	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001
552531002966	active site
552531002967	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
552531002968	D-xylulose kinase; Region: XylB; TIGR01312
552531002969	nucleotide binding site [chemical binding]; other site
552531002970	IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339
552531002971	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
552531002972	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
552531002973	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
552531002974	RF-1 domain; Region: RF-1; pfam00472
552531002975	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
552531002976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
552531002977	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
552531002978	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
552531002979	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
552531002980	Mg++ binding site [ion binding]; other site
552531002981	putative catalytic motif [active]
552531002982	substrate binding site [chemical binding]; other site
552531002983	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
552531002984	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
552531002985	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
552531002986	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
552531002987	active site
552531002988	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
552531002989	catalytic site [active]
552531002990	putative active site [active]
552531002991	putative substrate binding site [chemical binding]; other site
552531002992	dimer interface [polypeptide binding]; other site
552531002993	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531002994	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
552531002995	active site
552531002996	motif I; other site
552531002997	motif II; other site
552531002998	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
552531002999	AAA domain; Region: AAA_30; pfam13604
552531003000	PIF1-like helicase; Region: PIF1; pfam05970
552531003001	Protein of unknown function (DUF805); Region: DUF805; cl01224
552531003002	prolyl-tRNA synthetase; Provisional; Region: PRK09194
552531003003	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
552531003004	dimer interface [polypeptide binding]; other site
552531003005	motif 1; other site
552531003006	active site
552531003007	motif 2; other site
552531003008	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
552531003009	putative deacylase active site [active]
552531003010	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
552531003011	active site
552531003012	motif 3; other site
552531003013	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
552531003014	anticodon binding site; other site
552531003015	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
552531003016	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
552531003017	dimer interface [polypeptide binding]; other site
552531003018	ssDNA binding site [nucleotide binding]; other site
552531003019	tetramer (dimer of dimers) interface [polypeptide binding]; other site
552531003020	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
552531003021	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
552531003022	active site
552531003023	Zn binding site [ion binding]; other site
552531003024	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
552531003025	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
552531003026	Citrate synthase; Region: Citrate_synt; pfam00285
552531003027	oxalacetate binding site [chemical binding]; other site
552531003028	citrylCoA binding site [chemical binding]; other site
552531003029	coenzyme A binding site [chemical binding]; other site
552531003030	catalytic triad [active]
552531003031	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
552531003032	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535
552531003033	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
552531003034	putative trimer interface [polypeptide binding]; other site
552531003035	putative CoA binding site [chemical binding]; other site
552531003036	peptide chain release factor 2; Validated; Region: prfB; PRK00578
552531003037	This domain is found in peptide chain release factors; Region: PCRF; smart00937
552531003038	RF-1 domain; Region: RF-1; pfam00472
552531003039	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
552531003040	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531003041	Walker A/P-loop; other site
552531003042	ATP binding site [chemical binding]; other site
552531003043	Q-loop/lid; other site
552531003044	ABC transporter signature motif; other site
552531003045	Walker B; other site
552531003046	D-loop; other site
552531003047	H-loop/switch region; other site
552531003048	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
552531003049	FtsX-like permease family; Region: FtsX; pfam02687
552531003050	Surface antigen [General function prediction only]; Region: COG3942
552531003051	CHAP domain; Region: CHAP; pfam05257
552531003052	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
552531003053	SmpB-tmRNA interface; other site
552531003054	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552531003055	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
552531003056	substrate binding pocket [chemical binding]; other site
552531003057	membrane-bound complex binding site; other site
552531003058	hinge residues; other site
552531003059	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552531003060	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
552531003061	substrate binding pocket [chemical binding]; other site
552531003062	membrane-bound complex binding site; other site
552531003063	hinge residues; other site
552531003064	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
552531003065	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531003066	dimer interface [polypeptide binding]; other site
552531003067	conserved gate region; other site
552531003068	putative PBP binding loops; other site
552531003069	ABC-ATPase subunit interface; other site
552531003070	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
552531003071	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
552531003072	Walker A/P-loop; other site
552531003073	ATP binding site [chemical binding]; other site
552531003074	Q-loop/lid; other site
552531003075	ABC transporter signature motif; other site
552531003076	Walker B; other site
552531003077	D-loop; other site
552531003078	H-loop/switch region; other site
552531003079	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
552531003080	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
552531003081	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552531003082	active site
552531003083	phosphorylation site [posttranslational modification]
552531003084	intermolecular recognition site; other site
552531003085	dimerization interface [polypeptide binding]; other site
552531003086	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
552531003087	DNA binding residues [nucleotide binding]
552531003088	dimerization interface [polypeptide binding]; other site
552531003089	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
552531003090	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
552531003091	glutaminase active site [active]
552531003092	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
552531003093	dimer interface [polypeptide binding]; other site
552531003094	active site
552531003095	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
552531003096	dimer interface [polypeptide binding]; other site
552531003097	active site
552531003098	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
552531003099	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
552531003100	active site
552531003101	pantothenate kinase; Reviewed; Region: PRK13318
552531003102	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
552531003103	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
552531003104	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
552531003105	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531003106	dimer interface [polypeptide binding]; other site
552531003107	conserved gate region; other site
552531003108	putative PBP binding loops; other site
552531003109	ABC-ATPase subunit interface; other site
552531003110	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
552531003111	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531003112	dimer interface [polypeptide binding]; other site
552531003113	conserved gate region; other site
552531003114	putative PBP binding loops; other site
552531003115	ABC-ATPase subunit interface; other site
552531003116	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
552531003117	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
552531003118	Walker A/P-loop; other site
552531003119	ATP binding site [chemical binding]; other site
552531003120	Q-loop/lid; other site
552531003121	ABC transporter signature motif; other site
552531003122	Walker B; other site
552531003123	D-loop; other site
552531003124	H-loop/switch region; other site
552531003125	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
552531003126	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
552531003127	Walker A/P-loop; other site
552531003128	ATP binding site [chemical binding]; other site
552531003129	Q-loop/lid; other site
552531003130	ABC transporter signature motif; other site
552531003131	Walker B; other site
552531003132	D-loop; other site
552531003133	H-loop/switch region; other site
552531003134	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
552531003135	cystathionine gamma-synthase; Provisional; Region: PRK07811
552531003136	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
552531003137	homodimer interface [polypeptide binding]; other site
552531003138	substrate-cofactor binding pocket; other site
552531003139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531003140	catalytic residue [active]
552531003141	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
552531003142	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
552531003143	dimer interface [polypeptide binding]; other site
552531003144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531003145	catalytic residue [active]
552531003146	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
552531003147	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
552531003148	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552531003149	ATP binding site [chemical binding]; other site
552531003150	ATP binding site [chemical binding]; other site
552531003151	putative Mg++ binding site [ion binding]; other site
552531003152	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531003153	nucleotide binding region [chemical binding]; other site
552531003154	ATP-binding site [chemical binding]; other site
552531003155	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
552531003156	HRDC domain; Region: HRDC; pfam00570
552531003157	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
552531003158	putative active site [active]
552531003159	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
552531003160	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
552531003161	Protein of unknown function (DUF1706); Region: DUF1706; cl01748
552531003162	Protein of unknown function (DUF1706); Region: DUF1706; cl01748
552531003163	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
552531003164	active site
552531003165	8-oxo-dGMP binding site [chemical binding]; other site
552531003166	nudix motif; other site
552531003167	metal binding site [ion binding]; metal-binding site
552531003168	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
552531003169	PLD-like domain; Region: PLDc_2; pfam13091
552531003170	putative homodimer interface [polypeptide binding]; other site
552531003171	putative active site [active]
552531003172	catalytic site [active]
552531003173	DEAD-like helicases superfamily; Region: DEXDc; smart00487
552531003174	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552531003175	ATP binding site [chemical binding]; other site
552531003176	putative Mg++ binding site [ion binding]; other site
552531003177	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531003178	nucleotide binding region [chemical binding]; other site
552531003179	ATP-binding site [chemical binding]; other site
552531003180	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
552531003181	Fic family protein [Function unknown]; Region: COG3177
552531003182	Fic/DOC family; Region: Fic; cl00960
552531003183	Protein of unknown function DUF262; Region: DUF262; pfam03235
552531003184	Uncharacterized conserved protein [Function unknown]; Region: COG1479
552531003185	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
552531003186	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
552531003187	Fic/DOC family; Region: Fic; cl00960
552531003188	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
552531003189	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552531003190	Coenzyme A binding pocket [chemical binding]; other site
552531003191	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
552531003192	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
552531003193	Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172
552531003194	putative active site [active]
552531003195	metal binding site [ion binding]; metal-binding site
552531003196	S-ribosylhomocysteinase; Provisional; Region: PRK02260
552531003197	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
552531003198	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
552531003199	alanine racemase; Reviewed; Region: alr; PRK00053
552531003200	active site
552531003201	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
552531003202	dimer interface [polypeptide binding]; other site
552531003203	substrate binding site [chemical binding]; other site
552531003204	catalytic residues [active]
552531003205	DNA primase; Validated; Region: dnaG; PRK05667
552531003206	CHC2 zinc finger; Region: zf-CHC2; pfam01807
552531003207	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
552531003208	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
552531003209	active site
552531003210	metal binding site [ion binding]; metal-binding site
552531003211	interdomain interaction site; other site
552531003212	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
552531003213	Putative anion permease YbiR.  Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117
552531003214	transmembrane helices; other site
552531003215	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
552531003216	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
552531003217	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
552531003218	TPP-binding site; other site
552531003219	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
552531003220	PYR/PP interface [polypeptide binding]; other site
552531003221	dimer interface [polypeptide binding]; other site
552531003222	TPP binding site [chemical binding]; other site
552531003223	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
552531003224	AIR carboxylase; Region: AIRC; pfam00731
552531003225	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
552531003226	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
552531003227	NAD binding site [chemical binding]; other site
552531003228	ATP-grasp domain; Region: ATP-grasp; pfam02222
552531003229	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
552531003230	metal binding site 2 [ion binding]; metal-binding site
552531003231	putative DNA binding helix; other site
552531003232	metal binding site 1 [ion binding]; metal-binding site
552531003233	dimer interface [polypeptide binding]; other site
552531003234	structural Zn2+ binding site [ion binding]; other site
552531003235	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
552531003236	Putative esterase; Region: Esterase; pfam00756
552531003237	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
552531003238	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
552531003239	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
552531003240	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
552531003241	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
552531003242	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
552531003243	dimerization interface [polypeptide binding]; other site
552531003244	putative ATP binding site [chemical binding]; other site
552531003245	amidophosphoribosyltransferase; Provisional; Region: PRK07272
552531003246	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
552531003247	active site
552531003248	tetramer interface [polypeptide binding]; other site
552531003249	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552531003250	active site
552531003251	DNA polymerase IV; Reviewed; Region: PRK03103
552531003252	Y-family of DNA polymerases; Region: PolY; cl12025
552531003253	active site
552531003254	DNA binding site [nucleotide binding]
552531003255	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
552531003256	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900
552531003257	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
552531003258	Short C-terminal domain; Region: SHOCT; pfam09851
552531003259	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
552531003260	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
552531003261	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
552531003262	dimerization interface [polypeptide binding]; other site
552531003263	ATP binding site [chemical binding]; other site
552531003264	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
552531003265	dimerization interface [polypeptide binding]; other site
552531003266	ATP binding site [chemical binding]; other site
552531003267	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
552531003268	conserved cys residue [active]
552531003269	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
552531003270	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
552531003271	ATP binding site [chemical binding]; other site
552531003272	active site
552531003273	substrate binding site [chemical binding]; other site
552531003274	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
552531003275	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
552531003276	ATP-grasp domain; Region: ATP-grasp; pfam02222
552531003277	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
552531003278	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
552531003279	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
552531003280	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
552531003281	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552531003282	catalytic residue [active]
552531003283	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
552531003284	S17 interaction site [polypeptide binding]; other site
552531003285	S8 interaction site; other site
552531003286	16S rRNA interaction site [nucleotide binding]; other site
552531003287	streptomycin interaction site [chemical binding]; other site
552531003288	23S rRNA interaction site [nucleotide binding]; other site
552531003289	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
552531003290	30S ribosomal protein S7; Validated; Region: PRK05302
552531003291	elongation factor G; Reviewed; Region: PRK00007
552531003292	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
552531003293	G1 box; other site
552531003294	putative GEF interaction site [polypeptide binding]; other site
552531003295	GTP/Mg2+ binding site [chemical binding]; other site
552531003296	Switch I region; other site
552531003297	G2 box; other site
552531003298	G3 box; other site
552531003299	Switch II region; other site
552531003300	G4 box; other site
552531003301	G5 box; other site
552531003302	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
552531003303	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
552531003304	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
552531003305	elongation factor Tu; Reviewed; Region: PRK00049
552531003306	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
552531003307	G1 box; other site
552531003308	GEF interaction site [polypeptide binding]; other site
552531003309	GTP/Mg2+ binding site [chemical binding]; other site
552531003310	Switch I region; other site
552531003311	G2 box; other site
552531003312	G3 box; other site
552531003313	Switch II region; other site
552531003314	G4 box; other site
552531003315	G5 box; other site
552531003316	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
552531003317	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
552531003318	Antibiotic Binding Site [chemical binding]; other site
552531003319	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
552531003320	elongation factor P; Validated; Region: PRK00529
552531003321	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
552531003322	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
552531003323	RNA binding site [nucleotide binding]; other site
552531003324	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
552531003325	RNA binding site [nucleotide binding]; other site
552531003326	transcription antitermination factor NusB; Region: nusB; TIGR01951
552531003327	putative RNA binding site [nucleotide binding]; other site
552531003328	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
552531003329	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
552531003330	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
552531003331	catalytic site [active]
552531003332	subunit interface [polypeptide binding]; other site
552531003333	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
552531003334	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
552531003335	ATP-grasp domain; Region: ATP-grasp_4; cl17255
552531003336	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
552531003337	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
552531003338	ATP-grasp domain; Region: ATP-grasp_4; cl17255
552531003339	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
552531003340	IMP binding site; other site
552531003341	dimer interface [polypeptide binding]; other site
552531003342	interdomain contacts; other site
552531003343	partial ornithine binding site; other site
552531003344	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
552531003345	active site
552531003346	dimer interface [polypeptide binding]; other site
552531003347	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
552531003348	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
552531003349	catalytic site [active]
552531003350	G-X2-G-X-G-K; other site
552531003351	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
552531003352	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
552531003353	S-adenosylmethionine synthetase; Validated; Region: PRK05250
552531003354	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
552531003355	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
552531003356	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
552531003357	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
552531003358	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552531003359	S-adenosylmethionine binding site [chemical binding]; other site
552531003360	primosome assembly protein PriA; Provisional; Region: PRK14873
552531003361	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
552531003362	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
552531003363	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
552531003364	putative active site [active]
552531003365	substrate binding site [chemical binding]; other site
552531003366	putative cosubstrate binding site; other site
552531003367	catalytic site [active]
552531003368	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
552531003369	substrate binding site [chemical binding]; other site
552531003370	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
552531003371	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
552531003372	proteasome ATPase; Region: pup_AAA; TIGR03689
552531003373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531003374	Walker A motif; other site
552531003375	ATP binding site [chemical binding]; other site
552531003376	Walker B motif; other site
552531003377	arginine finger; other site
552531003378	Pup-ligase protein; Region: Pup_ligase; cl15463
552531003379	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
552531003380	active site
552531003381	ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687
552531003382	Pup-ligase protein; Region: Pup_ligase; cl15463
552531003383	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
552531003384	IHF dimer interface [polypeptide binding]; other site
552531003385	IHF - DNA interface [nucleotide binding]; other site
552531003386	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
552531003387	adenylosuccinate lyase; Provisional; Region: PRK09285
552531003388	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
552531003389	tetramer interface [polypeptide binding]; other site
552531003390	active site
552531003391	Secretory lipase; Region: LIP; pfam03583
552531003392	von Willebrand factor type A domain; Region: VWA_2; pfam13519
552531003393	metal ion-dependent adhesion site (MIDAS); other site
552531003394	von Willebrand factor type A domain; Region: VWA_2; pfam13519
552531003395	metal ion-dependent adhesion site (MIDAS); other site
552531003396	Protein of unknown function DUF58; Region: DUF58; pfam01882
552531003397	MoxR-like ATPases [General function prediction only]; Region: COG0714
552531003398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
552531003399	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
552531003400	ligand binding site [chemical binding]; other site
552531003401	active site
552531003402	UGI interface [polypeptide binding]; other site
552531003403	catalytic site [active]
552531003404	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
552531003405	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
552531003406	DNA-binding site [nucleotide binding]; DNA binding site
552531003407	RNA-binding motif; other site
552531003408	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
552531003409	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
552531003410	ring oligomerisation interface [polypeptide binding]; other site
552531003411	ATP/Mg binding site [chemical binding]; other site
552531003412	stacking interactions; other site
552531003413	hinge regions; other site
552531003414	Proteins of 100 residues with WXG; Region: WXG100; pfam06013
552531003415	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552531003416	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552531003417	active site
552531003418	phosphorylation site [posttranslational modification]
552531003419	intermolecular recognition site; other site
552531003420	dimerization interface [polypeptide binding]; other site
552531003421	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552531003422	DNA binding site [nucleotide binding]
552531003423	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
552531003424	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
552531003425	dimerization interface [polypeptide binding]; other site
552531003426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552531003427	dimer interface [polypeptide binding]; other site
552531003428	phosphorylation site [posttranslational modification]
552531003429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552531003430	ATP binding site [chemical binding]; other site
552531003431	Mg2+ binding site [ion binding]; other site
552531003432	G-X-G motif; other site
552531003433	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
552531003434	DNA-binding site [nucleotide binding]; DNA binding site
552531003435	RNA-binding motif; other site
552531003436	Protein of unknown function (DUF3027); Region: DUF3027; pfam11228
552531003437	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
552531003438	Ligand Binding Site [chemical binding]; other site
552531003439	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
552531003440	Ligand Binding Site [chemical binding]; other site
552531003441	Clp protease ATP binding subunit; Region: clpC; CHL00095
552531003442	Clp amino terminal domain; Region: Clp_N; pfam02861
552531003443	Clp amino terminal domain; Region: Clp_N; pfam02861
552531003444	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531003445	Walker A motif; other site
552531003446	ATP binding site [chemical binding]; other site
552531003447	Walker B motif; other site
552531003448	arginine finger; other site
552531003449	UvrB/uvrC motif; Region: UVR; pfam02151
552531003450	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531003451	Walker A motif; other site
552531003452	ATP binding site [chemical binding]; other site
552531003453	Walker B motif; other site
552531003454	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
552531003455	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
552531003456	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
552531003457	dimer interface [polypeptide binding]; other site
552531003458	anticodon binding site; other site
552531003459	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
552531003460	motif 1; other site
552531003461	dimer interface [polypeptide binding]; other site
552531003462	active site
552531003463	motif 2; other site
552531003464	GAD domain; Region: GAD; pfam02938
552531003465	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
552531003466	active site
552531003467	motif 3; other site
552531003468	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
552531003469	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
552531003470	dimer interface [polypeptide binding]; other site
552531003471	motif 1; other site
552531003472	active site
552531003473	motif 2; other site
552531003474	motif 3; other site
552531003475	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
552531003476	anticodon binding site; other site
552531003477	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
552531003478	Domain of Unknown Function (DUF349); Region: DUF349; pfam03993
552531003479	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
552531003480	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
552531003481	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
552531003482	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
552531003483	Walker A/P-loop; other site
552531003484	ATP binding site [chemical binding]; other site
552531003485	Q-loop/lid; other site
552531003486	ABC transporter signature motif; other site
552531003487	Walker B; other site
552531003488	D-loop; other site
552531003489	H-loop/switch region; other site
552531003490	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552531003491	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
552531003492	substrate binding pocket [chemical binding]; other site
552531003493	membrane-bound complex binding site; other site
552531003494	hinge residues; other site
552531003495	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531003496	dimer interface [polypeptide binding]; other site
552531003497	conserved gate region; other site
552531003498	ABC-ATPase subunit interface; other site
552531003499	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
552531003500	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531003501	dimer interface [polypeptide binding]; other site
552531003502	conserved gate region; other site
552531003503	putative PBP binding loops; other site
552531003504	ABC-ATPase subunit interface; other site
552531003505	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
552531003506	DEAD-like helicases superfamily; Region: DEXDc; smart00487
552531003507	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552531003508	ATP binding site [chemical binding]; other site
552531003509	putative Mg++ binding site [ion binding]; other site
552531003510	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531003511	nucleotide binding region [chemical binding]; other site
552531003512	ATP-binding site [chemical binding]; other site
552531003513	Domain of unknown function (DUF3516); Region: DUF3516; pfam12029
552531003514	recombination factor protein RarA; Reviewed; Region: PRK13342
552531003515	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531003516	Walker A motif; other site
552531003517	ATP binding site [chemical binding]; other site
552531003518	Walker B motif; other site
552531003519	arginine finger; other site
552531003520	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
552531003521	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531003522	putative substrate translocation pore; other site
552531003523	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531003524	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
552531003525	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
552531003526	acyl-activating enzyme (AAE) consensus motif; other site
552531003527	putative AMP binding site [chemical binding]; other site
552531003528	putative active site [active]
552531003529	putative CoA binding site [chemical binding]; other site
552531003530	Transposase, Mutator family; Region: Transposase_mut; pfam00872
552531003531	MULE transposase domain; Region: MULE; pfam10551
552531003532	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552531003533	Coenzyme A binding pocket [chemical binding]; other site
552531003534	Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952
552531003535	hypothetical protein; Provisional; Region: PRK11770
552531003536	Domain of unknown function (DUF307); Region: DUF307; pfam03733
552531003537	Domain of unknown function (DUF307); Region: DUF307; pfam03733
552531003538	Putative transcription activator [Transcription]; Region: TenA; COG0819
552531003539	Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103
552531003540	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
552531003541	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
552531003542	active site
552531003543	catalytic tetrad [active]
552531003544	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552531003545	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
552531003546	Walker A/P-loop; other site
552531003547	ATP binding site [chemical binding]; other site
552531003548	Q-loop/lid; other site
552531003549	ABC transporter signature motif; other site
552531003550	Walker B; other site
552531003551	D-loop; other site
552531003552	H-loop/switch region; other site
552531003553	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552531003554	Walker A/P-loop; other site
552531003555	ATP binding site [chemical binding]; other site
552531003556	Q-loop/lid; other site
552531003557	ABC transporter signature motif; other site
552531003558	Walker B; other site
552531003559	D-loop; other site
552531003560	H-loop/switch region; other site
552531003561	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
552531003562	KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089
552531003563	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531003564	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531003565	homodimer interface [polypeptide binding]; other site
552531003566	catalytic residue [active]
552531003567	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
552531003568	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531003569	Walker A/P-loop; other site
552531003570	ATP binding site [chemical binding]; other site
552531003571	Q-loop/lid; other site
552531003572	ABC transporter signature motif; other site
552531003573	Walker B; other site
552531003574	D-loop; other site
552531003575	H-loop/switch region; other site
552531003576	Ligase N family; Region: LIGANc; smart00532
552531003577	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
552531003578	nucleotide binding pocket [chemical binding]; other site
552531003579	K-X-D-G motif; other site
552531003580	catalytic site [active]
552531003581	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
552531003582	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
552531003583	Helix-hairpin-helix motif; Region: HHH_2; pfam12826
552531003584	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
552531003585	Dimer interface [polypeptide binding]; other site
552531003586	Domain of unknown function DUF59; Region: DUF59; cl00941
552531003587	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
552531003588	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
552531003589	glutamine synthetase, type I; Region: GlnA; TIGR00653
552531003590	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
552531003591	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
552531003592	Domain of unknown function (DUF4191); Region: DUF4191; pfam13829
552531003593	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
552531003594	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
552531003595	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552531003596	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
552531003597	Protein of unknown function (DUF3043); Region: DUF3043; pfam11241
552531003598	hypothetical protein; Provisional; Region: PRK07907
552531003599	M20 Dipeptidases; Region: M20_Dipept_like; cd03893
552531003600	active site
552531003601	metal binding site [ion binding]; metal-binding site
552531003602	dimer interface [polypeptide binding]; other site
552531003603	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
552531003604	Histidine kinase; Region: HisKA_3; pfam07730
552531003605	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
552531003606	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531003607	Q-loop/lid; other site
552531003608	ABC transporter signature motif; other site
552531003609	Walker B; other site
552531003610	D-loop; other site
552531003611	H-loop/switch region; other site
552531003612	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
552531003613	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552531003614	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
552531003615	Q-loop/lid; other site
552531003616	ABC transporter signature motif; other site
552531003617	Walker B; other site
552531003618	D-loop; other site
552531003619	H-loop/switch region; other site
552531003620	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552531003621	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
552531003622	Walker A/P-loop; other site
552531003623	ATP binding site [chemical binding]; other site
552531003624	Q-loop/lid; other site
552531003625	ABC transporter signature motif; other site
552531003626	Walker B; other site
552531003627	D-loop; other site
552531003628	H-loop/switch region; other site
552531003629	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
552531003630	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552531003631	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552531003632	Walker A/P-loop; other site
552531003633	ATP binding site [chemical binding]; other site
552531003634	Q-loop/lid; other site
552531003635	ABC transporter signature motif; other site
552531003636	Walker B; other site
552531003637	D-loop; other site
552531003638	H-loop/switch region; other site
552531003639	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
552531003640	FtsX-like permease family; Region: FtsX; pfam02687
552531003641	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
552531003642	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870
552531003643	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
552531003644	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
552531003645	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
552531003646	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
552531003647	dimer interface [polypeptide binding]; other site
552531003648	motif 1; other site
552531003649	active site
552531003650	motif 2; other site
552531003651	motif 3; other site
552531003652	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
552531003653	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
552531003654	putative tRNA-binding site [nucleotide binding]; other site
552531003655	B3/4 domain; Region: B3_4; pfam03483
552531003656	tRNA synthetase B5 domain; Region: B5; smart00874
552531003657	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
552531003658	dimer interface [polypeptide binding]; other site
552531003659	motif 1; other site
552531003660	motif 3; other site
552531003661	motif 2; other site
552531003662	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
552531003663	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
552531003664	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
552531003665	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
552531003666	heterotetramer interface [polypeptide binding]; other site
552531003667	active site pocket [active]
552531003668	cleavage site
552531003669	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
552531003670	feedback inhibition sensing region; other site
552531003671	homohexameric interface [polypeptide binding]; other site
552531003672	nucleotide binding site [chemical binding]; other site
552531003673	N-acetyl-L-glutamate binding site [chemical binding]; other site
552531003674	acetylornithine aminotransferase; Provisional; Region: argD; PRK03244
552531003675	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
552531003676	inhibitor-cofactor binding pocket; inhibition site
552531003677	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531003678	catalytic residue [active]
552531003679	ornithine carbamoyltransferase; Provisional; Region: PRK00779
552531003680	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
552531003681	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
552531003682	arginine repressor; Provisional; Region: PRK03341
552531003683	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
552531003684	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
552531003685	argininosuccinate synthase; Provisional; Region: PRK13820
552531003686	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
552531003687	ANP binding site [chemical binding]; other site
552531003688	Substrate Binding Site II [chemical binding]; other site
552531003689	Substrate Binding Site I [chemical binding]; other site
552531003690	argininosuccinate lyase; Provisional; Region: PRK00855
552531003691	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
552531003692	active sites [active]
552531003693	tetramer interface [polypeptide binding]; other site
552531003694	acetoin reductases; Region: 23BDH; TIGR02415
552531003695	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
552531003696	NAD(P) binding site [chemical binding]; other site
552531003697	active site
552531003698	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552531003699	Zn2+ binding site [ion binding]; other site
552531003700	Mg2+ binding site [ion binding]; other site
552531003701	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
552531003702	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
552531003703	active site
552531003704	HIGH motif; other site
552531003705	dimer interface [polypeptide binding]; other site
552531003706	KMSKS motif; other site
552531003707	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552531003708	RNA binding surface [nucleotide binding]; other site
552531003709	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
552531003710	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531003711	active site
552531003712	motif I; other site
552531003713	motif II; other site
552531003714	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531003715	motif II; other site
552531003716	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
552531003717	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552531003718	RNA binding surface [nucleotide binding]; other site
552531003719	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552531003720	S-adenosylmethionine binding site [chemical binding]; other site
552531003721	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
552531003722	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
552531003723	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
552531003724	TrkA-N domain; Region: TrkA_N; pfam02254
552531003725	TrkA-C domain; Region: TrkA_C; pfam02080
552531003726	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372
552531003727	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
552531003728	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
552531003729	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
552531003730	Walker A/P-loop; other site
552531003731	ATP binding site [chemical binding]; other site
552531003732	Q-loop/lid; other site
552531003733	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
552531003734	ABC transporter signature motif; other site
552531003735	Walker B; other site
552531003736	D-loop; other site
552531003737	H-loop/switch region; other site
552531003738	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
552531003739	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
552531003740	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531003741	motif II; other site
552531003742	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
552531003743	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
552531003744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531003745	catalytic residue [active]
552531003746	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
552531003747	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
552531003748	putative catalytic cysteine [active]
552531003749	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
552531003750	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
552531003751	active site
552531003752	(T/H)XGH motif; other site
552531003753	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
552531003754	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092
552531003755	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552531003756	active site
552531003757	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352
552531003758	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
552531003759	Substrate binding site; other site
552531003760	Mg++ binding site; other site
552531003761	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
552531003762	active site
552531003763	substrate binding site [chemical binding]; other site
552531003764	CoA binding site [chemical binding]; other site
552531003765	Oligomerisation domain; Region: Oligomerisation; pfam02410
552531003766	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531003767	catalytic core [active]
552531003768	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
552531003769	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531003770	catalytic core [active]
552531003771	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
552531003772	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
552531003773	Cl binding site [ion binding]; other site
552531003774	oligomer interface [polypeptide binding]; other site
552531003775	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
552531003776	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
552531003777	substrate binding pocket [chemical binding]; other site
552531003778	membrane-bound complex binding site; other site
552531003779	hinge residues; other site
552531003780	aminoacyl-tRNA ligase; Region: PLN02563
552531003781	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
552531003782	active site
552531003783	HIGH motif; other site
552531003784	nucleotide binding site [chemical binding]; other site
552531003785	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
552531003786	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
552531003787	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
552531003788	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
552531003789	active site
552531003790	KMSKS motif; other site
552531003791	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
552531003792	tRNA binding surface [nucleotide binding]; other site
552531003793	Helix-hairpin-helix motif; Region: HHH; pfam00633
552531003794	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
552531003795	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
552531003796	Competence protein; Region: Competence; pfam03772
552531003797	hypothetical protein; Reviewed; Region: PRK07914
552531003798	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
552531003799	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
552531003800	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
552531003801	Glycoprotease family; Region: Peptidase_M22; pfam00814
552531003802	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
552531003803	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552531003804	Coenzyme A binding pocket [chemical binding]; other site
552531003805	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
552531003806	UGMP family protein; Validated; Region: PRK09604
552531003807	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
552531003808	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
552531003809	isocitrate dehydrogenase; Validated; Region: PRK08299
552531003810	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649
552531003811	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
552531003812	phosphate binding site [ion binding]; other site
552531003813	AMP-binding domain protein; Validated; Region: PRK08315
552531003814	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
552531003815	putative active site [active]
552531003816	putative CoA binding site [chemical binding]; other site
552531003817	putative AMP binding site [chemical binding]; other site
552531003818	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
552531003819	active site
552531003820	catalytic residues [active]
552531003821	metal binding site [ion binding]; metal-binding site
552531003822	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
552531003823	rRNA interaction site [nucleotide binding]; other site
552531003824	S8 interaction site; other site
552531003825	putative laminin-1 binding site; other site
552531003826	elongation factor Ts; Provisional; Region: tsf; PRK09377
552531003827	UBA/TS-N domain; Region: UBA; pfam00627
552531003828	Elongation factor TS; Region: EF_TS; pfam00889
552531003829	Elongation factor TS; Region: EF_TS; pfam00889
552531003830	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
552531003831	putative nucleotide binding site [chemical binding]; other site
552531003832	uridine monophosphate binding site [chemical binding]; other site
552531003833	homohexameric interface [polypeptide binding]; other site
552531003834	ribosome recycling factor; Reviewed; Region: frr; PRK00083
552531003835	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
552531003836	hinge region; other site
552531003837	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
552531003838	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
552531003839	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459
552531003840	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552531003841	FeS/SAM binding site; other site
552531003842	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
552531003843	WHG domain; Region: WHG; pfam13305
552531003844	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
552531003845	Walker A/P-loop; other site
552531003846	ATP binding site [chemical binding]; other site
552531003847	ABC transporter; Region: ABC_tran; pfam00005
552531003848	Q-loop/lid; other site
552531003849	ABC transporter signature motif; other site
552531003850	Walker B; other site
552531003851	D-loop; other site
552531003852	H-loop/switch region; other site
552531003853	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
552531003854	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
552531003855	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
552531003856	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
552531003857	substrate binding site [chemical binding]; other site
552531003858	glutamase interaction surface [polypeptide binding]; other site
552531003859	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
552531003860	anthranilate synthase component I; Provisional; Region: PRK13571
552531003861	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
552531003862	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
552531003863	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
552531003864	putative uracil binding site [chemical binding]; other site
552531003865	putative active site [active]
552531003866	bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802
552531003867	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
552531003868	active site
552531003869	ribulose/triose binding site [chemical binding]; other site
552531003870	phosphate binding site [ion binding]; other site
552531003871	substrate (anthranilate) binding pocket [chemical binding]; other site
552531003872	product (indole) binding pocket [chemical binding]; other site
552531003873	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
552531003874	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531003875	catalytic residue [active]
552531003876	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
552531003877	substrate binding site [chemical binding]; other site
552531003878	active site
552531003879	catalytic residues [active]
552531003880	heterodimer interface [polypeptide binding]; other site
552531003881	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
552531003882	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
552531003883	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
552531003884	substrate binding site [chemical binding]; other site
552531003885	hexamer interface [polypeptide binding]; other site
552531003886	metal binding site [ion binding]; metal-binding site
552531003887	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547
552531003888	homodimer interface [polypeptide binding]; other site
552531003889	putative metal binding site [ion binding]; other site
552531003890	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
552531003891	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
552531003892	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
552531003893	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
552531003894	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
552531003895	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
552531003896	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
552531003897	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
552531003898	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
552531003899	phosphopeptide binding site; other site
552531003900	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
552531003901	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
552531003902	DNA binding residues [nucleotide binding]
552531003903	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
552531003904	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
552531003905	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
552531003906	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531003907	motif II; other site
552531003908	Domain of unknown function (DUF4109); Region: DUF4109; pfam13397
552531003909	DEAD-like helicases superfamily; Region: DEXDc; smart00487
552531003910	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552531003911	ATP binding site [chemical binding]; other site
552531003912	putative Mg++ binding site [ion binding]; other site
552531003913	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531003914	nucleotide binding region [chemical binding]; other site
552531003915	ATP-binding site [chemical binding]; other site
552531003916	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
552531003917	Predicted transcriptional regulator [Transcription]; Region: COG2378
552531003918	WYL domain; Region: WYL; pfam13280
552531003919	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
552531003920	active site
552531003921	bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518
552531003922	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
552531003923	active site
552531003924	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
552531003925	CMP-binding site; other site
552531003926	The sites determining sugar specificity; other site
552531003927	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
552531003928	G1 box; other site
552531003929	GTP/Mg2+ binding site [chemical binding]; other site
552531003930	Switch I region; other site
552531003931	G2 box; other site
552531003932	Switch II region; other site
552531003933	G3 box; other site
552531003934	G4 box; other site
552531003935	G5 box; other site
552531003936	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
552531003937	G1 box; other site
552531003938	GTP/Mg2+ binding site [chemical binding]; other site
552531003939	Switch I region; other site
552531003940	G2 box; other site
552531003941	G3 box; other site
552531003942	Switch II region; other site
552531003943	G4 box; other site
552531003944	G5 box; other site
552531003945	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
552531003946	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552531003947	RNA binding surface [nucleotide binding]; other site
552531003948	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
552531003949	active site
552531003950	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200
552531003951	amphipathic channel; other site
552531003952	Asn-Pro-Ala signature motifs; other site
552531003953	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
552531003954	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
552531003955	purine monophosphate binding site [chemical binding]; other site
552531003956	dimer interface [polypeptide binding]; other site
552531003957	putative catalytic residues [active]
552531003958	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
552531003959	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
552531003960	CoA binding domain; Region: CoA_binding; pfam02629
552531003961	CoA-ligase; Region: Ligase_CoA; pfam00549
552531003962	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
552531003963	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
552531003964	CoA-ligase; Region: Ligase_CoA; pfam00549
552531003965	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552531003966	active site
552531003967	Preprotein translocase subunit; Region: YajC; pfam02699
552531003968	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
552531003969	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531003970	Walker A motif; other site
552531003971	ATP binding site [chemical binding]; other site
552531003972	Walker B motif; other site
552531003973	arginine finger; other site
552531003974	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
552531003975	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
552531003976	RuvA N terminal domain; Region: RuvA_N; pfam01330
552531003977	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
552531003978	Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039
552531003979	active site
552531003980	putative DNA-binding cleft [nucleotide binding]; other site
552531003981	dimer interface [polypeptide binding]; other site
552531003982	hypothetical protein; Validated; Region: PRK00110
552531003983	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
552531003984	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
552531003985	lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK07920
552531003986	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
552531003987	putative acyl-acceptor binding pocket; other site
552531003988	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
552531003989	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
552531003990	thiS-thiF/thiG interaction site; other site
552531003991	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305
552531003992	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
552531003993	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
552531003994	active site
552531003995	dimer interface [polypeptide binding]; other site
552531003996	motif 1; other site
552531003997	motif 2; other site
552531003998	motif 3; other site
552531003999	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
552531004000	anticodon binding site; other site
552531004001	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552531004002	ABC transporter; Region: ABC_tran; pfam00005
552531004003	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
552531004004	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552531004005	Coenzyme A binding pocket [chemical binding]; other site
552531004006	PAC2 family; Region: PAC2; pfam09754
552531004007	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
552531004008	Fructosamine kinase; Region: Fructosamin_kin; cl17579
552531004009	chaperone protein DnaJ; Provisional; Region: PRK14278
552531004010	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
552531004011	HSP70 interaction site [polypeptide binding]; other site
552531004012	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
552531004013	Zn binding sites [ion binding]; other site
552531004014	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
552531004015	dimer interface [polypeptide binding]; other site
552531004016	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
552531004017	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
552531004018	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
552531004019	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
552531004020	TPP-binding site [chemical binding]; other site
552531004021	dimer interface [polypeptide binding]; other site
552531004022	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
552531004023	PYR/PP interface [polypeptide binding]; other site
552531004024	dimer interface [polypeptide binding]; other site
552531004025	TPP binding site [chemical binding]; other site
552531004026	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
552531004027	Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955
552531004028	putative active site [active]
552531004029	transaldolase; Provisional; Region: PRK03903
552531004030	catalytic residue [active]
552531004031	hypothetical protein; Validated; Region: PRK07682
552531004032	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531004033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531004034	homodimer interface [polypeptide binding]; other site
552531004035	catalytic residue [active]
552531004036	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
552531004037	AsnC family; Region: AsnC_trans_reg; pfam01037
552531004038	bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355
552531004039	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552531004040	non-specific DNA binding site [nucleotide binding]; other site
552531004041	salt bridge; other site
552531004042	sequence-specific DNA binding site [nucleotide binding]; other site
552531004043	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531004044	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531004045	homodimer interface [polypeptide binding]; other site
552531004046	catalytic residue [active]
552531004047	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
552531004048	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531004049	active site
552531004050	motif I; other site
552531004051	motif II; other site
552531004052	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531004053	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
552531004054	triosephosphate isomerase; Provisional; Region: PRK14567
552531004055	substrate binding site [chemical binding]; other site
552531004056	dimer interface [polypeptide binding]; other site
552531004057	catalytic triad [active]
552531004058	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
552531004059	Phosphoglycerate kinase; Region: PGK; pfam00162
552531004060	substrate binding site [chemical binding]; other site
552531004061	hinge regions; other site
552531004062	ADP binding site [chemical binding]; other site
552531004063	catalytic site [active]
552531004064	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
552531004065	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
552531004066	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
552531004067	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
552531004068	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
552531004069	shikimate binding site; other site
552531004070	NAD(P) binding site [chemical binding]; other site
552531004071	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666
552531004072	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
552531004073	GIY-YIG motif/motif A; other site
552531004074	active site
552531004075	catalytic site [active]
552531004076	putative DNA binding site [nucleotide binding]; other site
552531004077	metal binding site [ion binding]; metal-binding site
552531004078	UvrB/uvrC motif; Region: UVR; pfam02151
552531004079	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
552531004080	Helix-hairpin-helix motif; Region: HHH; pfam00633
552531004081	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
552531004082	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
552531004083	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
552531004084	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
552531004085	MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032
552531004086	putative active site [active]
552531004087	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
552531004088	Predicted esterase [General function prediction only]; Region: COG0400
552531004089	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
552531004090	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531004091	Walker A/P-loop; other site
552531004092	ATP binding site [chemical binding]; other site
552531004093	Q-loop/lid; other site
552531004094	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552531004095	ABC transporter signature motif; other site
552531004096	Walker B; other site
552531004097	D-loop; other site
552531004098	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
552531004099	Cation efflux family; Region: Cation_efflux; pfam01545
552531004100	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
552531004101	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
552531004102	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
552531004103	active site
552531004104	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
552531004105	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
552531004106	putative substrate binding site [chemical binding]; other site
552531004107	putative ATP binding site [chemical binding]; other site
552531004108	peroxiredoxin; Region: AhpC; TIGR03137
552531004109	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
552531004110	dimer interface [polypeptide binding]; other site
552531004111	decamer (pentamer of dimers) interface [polypeptide binding]; other site
552531004112	catalytic triad [active]
552531004113	peroxidatic and resolving cysteines [active]
552531004114	putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143
552531004115	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
552531004116	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
552531004117	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
552531004118	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
552531004119	Transcriptional regulator [Transcription]; Region: LysR; COG0583
552531004120	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
552531004121	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
552531004122	dimerization interface [polypeptide binding]; other site
552531004123	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
552531004124	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
552531004125	motif II; other site
552531004126	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
552531004127	putative active site [active]
552531004128	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614
552531004129	Predicted transcriptional regulators [Transcription]; Region: COG1733
552531004130	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
552531004131	putative acetyltransferase; Provisional; Region: PRK03624
552531004132	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552531004133	Coenzyme A binding pocket [chemical binding]; other site
552531004134	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552531004135	active site
552531004136	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
552531004137	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
552531004138	heterodimer interface [polypeptide binding]; other site
552531004139	active site
552531004140	FMN binding site [chemical binding]; other site
552531004141	homodimer interface [polypeptide binding]; other site
552531004142	substrate binding site [chemical binding]; other site
552531004143	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
552531004144	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
552531004145	FAD binding pocket [chemical binding]; other site
552531004146	FAD binding motif [chemical binding]; other site
552531004147	phosphate binding motif [ion binding]; other site
552531004148	beta-alpha-beta structure motif; other site
552531004149	NAD binding pocket [chemical binding]; other site
552531004150	Iron coordination center [ion binding]; other site
552531004151	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
552531004152	active site
552531004153	dimer interface [polypeptide binding]; other site
552531004154	dihydroorotase; Validated; Region: pyrC; PRK09357
552531004155	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
552531004156	active site
552531004157	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
552531004158	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
552531004159	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
552531004160	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
552531004161	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
552531004162	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
552531004163	Domain of unknown function (DUF4186); Region: DUF4186; pfam13811
552531004164	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109
552531004165	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
552531004166	metal binding triad; other site
552531004167	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
552531004168	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
552531004169	metal binding triad; other site
552531004170	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
552531004171	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
552531004172	FAD binding site [chemical binding]; other site
552531004173	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
552531004174	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
552531004175	THF binding site; other site
552531004176	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
552531004177	substrate binding site [chemical binding]; other site
552531004178	THF binding site; other site
552531004179	zinc-binding site [ion binding]; other site
552531004180	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531004181	catalytic core [active]
552531004182	tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519
552531004183	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552531004184	S-adenosylmethionine binding site [chemical binding]; other site
552531004185	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
552531004186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531004187	Walker A/P-loop; other site
552531004188	ATP binding site [chemical binding]; other site
552531004189	Q-loop/lid; other site
552531004190	ABC transporter signature motif; other site
552531004191	Walker B; other site
552531004192	D-loop; other site
552531004193	H-loop/switch region; other site
552531004194	glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149
552531004195	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
552531004196	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
552531004197	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
552531004198	catalytic triad [active]
552531004199	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
552531004200	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
552531004201	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
552531004202	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
552531004203	active site
552531004204	dimer interface [polypeptide binding]; other site
552531004205	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
552531004206	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
552531004207	active site
552531004208	FMN binding site [chemical binding]; other site
552531004209	substrate binding site [chemical binding]; other site
552531004210	3Fe-4S cluster binding site [ion binding]; other site
552531004211	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
552531004212	domain interface; other site
552531004213	coproporphyrinogen III oxidase; Validated; Region: PRK05628
552531004214	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552531004215	FeS/SAM binding site; other site
552531004216	HemN C-terminal domain; Region: HemN_C; pfam06969
552531004217	GTP-binding protein LepA; Provisional; Region: PRK05433
552531004218	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
552531004219	G1 box; other site
552531004220	putative GEF interaction site [polypeptide binding]; other site
552531004221	GTP/Mg2+ binding site [chemical binding]; other site
552531004222	Switch I region; other site
552531004223	G2 box; other site
552531004224	G3 box; other site
552531004225	Switch II region; other site
552531004226	G4 box; other site
552531004227	G5 box; other site
552531004228	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
552531004229	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
552531004230	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
552531004231	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
552531004232	UPF0126 domain; Region: UPF0126; pfam03458
552531004233	Predicted membrane protein [Function unknown]; Region: COG2860
552531004234	UPF0126 domain; Region: UPF0126; pfam03458
552531004235	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
552531004236	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
552531004237	homodimer interface [polypeptide binding]; other site
552531004238	substrate-cofactor binding pocket; other site
552531004239	catalytic residue [active]
552531004240	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
552531004241	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
552531004242	5S rRNA interface [nucleotide binding]; other site
552531004243	CTC domain interface [polypeptide binding]; other site
552531004244	L16 interface [polypeptide binding]; other site
552531004245	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
552531004246	Serine hydrolase (FSH1); Region: FSH1; pfam03959
552531004247	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282
552531004248	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
552531004249	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
552531004250	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
552531004251	NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288
552531004252	ligand binding site [chemical binding]; other site
552531004253	homodimer interface [polypeptide binding]; other site
552531004254	NAD(P) binding site [chemical binding]; other site
552531004255	trimer interface B [polypeptide binding]; other site
552531004256	trimer interface A [polypeptide binding]; other site
552531004257	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
552531004258	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
552531004259	acyl-activating enzyme (AAE) consensus motif; other site
552531004260	putative AMP binding site [chemical binding]; other site
552531004261	putative active site [active]
552531004262	putative CoA binding site [chemical binding]; other site
552531004263	GTPase Era; Reviewed; Region: era; PRK00089
552531004264	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
552531004265	G1 box; other site
552531004266	GTP/Mg2+ binding site [chemical binding]; other site
552531004267	Switch I region; other site
552531004268	G2 box; other site
552531004269	Switch II region; other site
552531004270	G3 box; other site
552531004271	G4 box; other site
552531004272	G5 box; other site
552531004273	KH domain; Region: KH_2; pfam07650
552531004274	Domain of unknown function DUF21; Region: DUF21; pfam01595
552531004275	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
552531004276	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
552531004277	Transporter associated domain; Region: CorC_HlyC; smart01091
552531004278	metal-binding heat shock protein; Provisional; Region: PRK00016
552531004279	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
552531004280	PhoH-like protein; Region: PhoH; pfam02562
552531004281	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
552531004282	nucleotide binding site/active site [active]
552531004283	HIT family signature motif; other site
552531004284	catalytic residue [active]
552531004285	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
552531004286	RNA methyltransferase, RsmE family; Region: TIGR00046
552531004287	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
552531004288	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
552531004289	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
552531004290	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
552531004291	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
552531004292	ligand binding site; other site
552531004293	oligomer interface; other site
552531004294	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
552531004295	dimer interface [polypeptide binding]; other site
552531004296	N-terminal domain interface [polypeptide binding]; other site
552531004297	sulfate 1 binding site; other site
552531004298	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
552531004299	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
552531004300	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
552531004301	trimerization site [polypeptide binding]; other site
552531004302	active site
552531004303	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
552531004304	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
552531004305	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
552531004306	catalytic residue [active]
552531004307	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
552531004308	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
552531004309	Walker A/P-loop; other site
552531004310	ATP binding site [chemical binding]; other site
552531004311	Q-loop/lid; other site
552531004312	ABC transporter signature motif; other site
552531004313	Walker B; other site
552531004314	D-loop; other site
552531004315	H-loop/switch region; other site
552531004316	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
552531004317	FeS assembly protein SufD; Region: sufD; TIGR01981
552531004318	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
552531004319	FeS assembly protein SufB; Region: sufB; TIGR01980
552531004320	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
552531004321	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
552531004322	CTP synthetase; Validated; Region: pyrG; PRK05380
552531004323	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
552531004324	Catalytic site [active]
552531004325	active site
552531004326	UTP binding site [chemical binding]; other site
552531004327	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
552531004328	active site
552531004329	putative oxyanion hole; other site
552531004330	catalytic triad [active]
552531004331	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
552531004332	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
552531004333	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
552531004334	potential frameshift: common BLAST hit: gi|283455931|ref|YP_003360495.1| Pullulanase
552531004335	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
552531004336	active site
552531004337	catalytic site [active]
552531004338	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
552531004339	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
552531004340	active site
552531004341	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
552531004342	catalytic nucleophile [active]
552531004343	GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446
552531004344	GIY-YIG motif/motif A; other site
552531004345	putative active site [active]
552531004346	putative metal binding site [ion binding]; other site
552531004347	Dehydroquinase class II; Region: DHquinase_II; pfam01220
552531004348	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
552531004349	trimer interface [polypeptide binding]; other site
552531004350	active site
552531004351	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021
552531004352	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
552531004353	ADP binding site [chemical binding]; other site
552531004354	magnesium binding site [ion binding]; other site
552531004355	putative shikimate binding site; other site
552531004356	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
552531004357	active site
552531004358	dimer interface [polypeptide binding]; other site
552531004359	metal binding site [ion binding]; metal-binding site
552531004360	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
552531004361	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
552531004362	Tetramer interface [polypeptide binding]; other site
552531004363	active site
552531004364	FMN-binding site [chemical binding]; other site
552531004365	YceG-like family; Region: YceG; pfam02618
552531004366	proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666
552531004367	dimerization interface [polypeptide binding]; other site
552531004368	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
552531004369	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
552531004370	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
552531004371	motif 1; other site
552531004372	active site
552531004373	motif 2; other site
552531004374	motif 3; other site
552531004375	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
552531004376	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
552531004377	catalytic core [active]
552531004378	Membrane protein of unknown function; Region: DUF360; pfam04020
552531004379	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
552531004380	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
552531004381	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
552531004382	RNA binding surface [nucleotide binding]; other site
552531004383	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
552531004384	Part of AAA domain; Region: AAA_19; pfam13245
552531004385	Family description; Region: UvrD_C_2; pfam13538
552531004386	xanthine permease; Region: pbuX; TIGR03173
552531004387	Protein of unknown function (DUF3737); Region: DUF3737; pfam12541
552531004388	succinyldiaminopimelate transaminase; Region: DapC; TIGR03537
552531004389	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531004390	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531004391	homodimer interface [polypeptide binding]; other site
552531004392	catalytic residue [active]
552531004393	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
552531004394	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
552531004395	active site
552531004396	Na/Ca binding site [ion binding]; other site
552531004397	catalytic site [active]
552531004398	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
552531004399	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
552531004400	catalytic triad [active]
552531004401	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
552531004402	putative deacylase active site [active]
552531004403	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
552531004404	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
552531004405	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
552531004406	Walker A/P-loop; other site
552531004407	ATP binding site [chemical binding]; other site
552531004408	Q-loop/lid; other site
552531004409	ABC transporter signature motif; other site
552531004410	Walker B; other site
552531004411	D-loop; other site
552531004412	H-loop/switch region; other site
552531004413	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
552531004414	DNA-binding site [nucleotide binding]; DNA binding site
552531004415	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
552531004416	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552531004417	non-specific DNA binding site [nucleotide binding]; other site
552531004418	salt bridge; other site
552531004419	sequence-specific DNA binding site [nucleotide binding]; other site
552531004420	Chorismate mutase type II; Region: CM_2; cl00693
552531004421	hypothetical protein; Provisional; Region: PRK06761
552531004422	hypothetical protein; Provisional; Region: PRK06761
552531004423	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
552531004424	Coenzyme A binding pocket [chemical binding]; other site
552531004425	AAA domain; Region: AAA_17; pfam13207
552531004426	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
552531004427	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
552531004428	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
552531004429	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
552531004430	G1 box; other site
552531004431	putative GEF interaction site [polypeptide binding]; other site
552531004432	GTP/Mg2+ binding site [chemical binding]; other site
552531004433	Switch I region; other site
552531004434	G2 box; other site
552531004435	G3 box; other site
552531004436	Switch II region; other site
552531004437	G4 box; other site
552531004438	G5 box; other site
552531004439	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
552531004440	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
552531004441	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
552531004442	Transposase domain (DUF772); Region: DUF772; pfam05598
552531004443	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
552531004444	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
552531004445	GMP synthase; Reviewed; Region: guaA; PRK00074
552531004446	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
552531004447	AMP/PPi binding site [chemical binding]; other site
552531004448	candidate oxyanion hole; other site
552531004449	catalytic triad [active]
552531004450	potential glutamine specificity residues [chemical binding]; other site
552531004451	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
552531004452	ATP Binding subdomain [chemical binding]; other site
552531004453	Ligand Binding sites [chemical binding]; other site
552531004454	Dimerization subdomain; other site
552531004455	putative phosphoketolase; Provisional; Region: PRK05261
552531004456	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
552531004457	TPP-binding site; other site
552531004458	XFP C-terminal domain; Region: XFP_C; pfam09363
552531004459	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
552531004460	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
552531004461	propionate/acetate kinase; Provisional; Region: PRK12379
552531004462	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
552531004463	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
552531004464	hinge; other site
552531004465	active site
552531004466	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
552531004467	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
552531004468	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
552531004469	active site
552531004470	catalytic site [active]
552531004471	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
552531004472	dimer interface [polypeptide binding]; other site
552531004473	ADP-ribose binding site [chemical binding]; other site
552531004474	active site
552531004475	nudix motif; other site
552531004476	metal binding site [ion binding]; metal-binding site
552531004477	Uncharacterized conserved protein [Function unknown]; Region: COG0327
552531004478	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
552531004479	potential frameshift: common BLAST hit: gi|241196414|ref|YP_002969969.1| DNA polymerase I
552531004480	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
552531004481	active site
552531004482	DNA binding site [nucleotide binding]
552531004483	catalytic site [active]
552531004484	5'-3' exonuclease; Region: 53EXOc; smart00475
552531004485	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
552531004486	active site
552531004487	metal binding site 1 [ion binding]; metal-binding site
552531004488	putative 5' ssDNA interaction site; other site
552531004489	metal binding site 3; metal-binding site
552531004490	metal binding site 2 [ion binding]; metal-binding site
552531004491	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
552531004492	putative DNA binding site [nucleotide binding]; other site
552531004493	putative metal binding site [ion binding]; other site
552531004494	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
552531004495	active site
552531004496	substrate binding site [chemical binding]; other site
552531004497	catalytic site [active]
552531004498	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
552531004499	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
552531004500	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552531004501	active site
552531004502	phosphorylation site [posttranslational modification]
552531004503	intermolecular recognition site; other site
552531004504	dimerization interface [polypeptide binding]; other site
552531004505	ANTAR domain; Region: ANTAR; pfam03861
552531004506	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
552531004507	dimer interface [polypeptide binding]; other site
552531004508	ADP-ribose binding site [chemical binding]; other site
552531004509	active site
552531004510	nudix motif; other site
552531004511	metal binding site [ion binding]; metal-binding site
552531004512	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
552531004513	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
552531004514	domain interfaces; other site
552531004515	active site
552531004516	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
552531004517	excinuclease ABC subunit B; Provisional; Region: PRK05298
552531004518	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552531004519	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531004520	nucleotide binding region [chemical binding]; other site
552531004521	ATP-binding site [chemical binding]; other site
552531004522	Ultra-violet resistance protein B; Region: UvrB; pfam12344
552531004523	UvrB/uvrC motif; Region: UVR; pfam02151
552531004524	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
552531004525	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
552531004526	CoA-binding site [chemical binding]; other site
552531004527	ATP-binding [chemical binding]; other site
552531004528	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193
552531004529	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
552531004530	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
552531004531	homodimer interface [polypeptide binding]; other site
552531004532	NADP binding site [chemical binding]; other site
552531004533	substrate binding site [chemical binding]; other site
552531004534	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
552531004535	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
552531004536	intersubunit interface [polypeptide binding]; other site
552531004537	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
552531004538	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
552531004539	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
552531004540	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
552531004541	ABC-ATPase subunit  interface; other site
552531004542	dimer interface [polypeptide binding]; other site
552531004543	putative PBP binding regions; other site
552531004544	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
552531004545	homotrimer interaction site [polypeptide binding]; other site
552531004546	zinc binding site [ion binding]; other site
552531004547	CDP-binding sites; other site
552531004548	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588
552531004549	glycogen branching enzyme; Provisional; Region: PRK05402
552531004550	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
552531004551	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
552531004552	active site
552531004553	catalytic site [active]
552531004554	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
552531004555	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
552531004556	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552531004557	active site
552531004558	phosphorylation site [posttranslational modification]
552531004559	intermolecular recognition site; other site
552531004560	dimerization interface [polypeptide binding]; other site
552531004561	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
552531004562	DNA binding site [nucleotide binding]
552531004563	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
552531004564	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
552531004565	dimerization interface [polypeptide binding]; other site
552531004566	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
552531004567	dimer interface [polypeptide binding]; other site
552531004568	phosphorylation site [posttranslational modification]
552531004569	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552531004570	ATP binding site [chemical binding]; other site
552531004571	Mg2+ binding site [ion binding]; other site
552531004572	G-X-G motif; other site
552531004573	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
552531004574	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
552531004575	active site
552531004576	Eukaryotic phosphomannomutase; Region: PMM; cl17107
552531004577	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
552531004578	Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954
552531004579	Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632
552531004580	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
552531004581	Transcriptional regulator [Transcription]; Region: LytR; COG1316
552531004582	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
552531004583	Transcription factor WhiB; Region: Whib; pfam02467
552531004584	Signal transduction histidine kinase; Region: H_kinase_N; pfam12282
552531004585	PAS fold; Region: PAS_4; pfam08448
552531004586	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
552531004587	Histidine kinase; Region: HisKA_2; pfam07568
552531004588	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552531004589	ATP binding site [chemical binding]; other site
552531004590	Mg2+ binding site [ion binding]; other site
552531004591	G-X-G motif; other site
552531004592	V-type ATP synthase subunit E; Provisional; Region: PRK01558
552531004593	Haemolysin-III related; Region: HlyIII; pfam03006
552531004594	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
552531004595	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
552531004596	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
552531004597	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
552531004598	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
552531004599	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
552531004600	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
552531004601	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
552531004602	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
552531004603	Protein of unknown function (DUF501); Region: DUF501; pfam04417
552531004604	Septum formation initiator; Region: DivIC; pfam04977
552531004605	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
552531004606	enolase; Provisional; Region: eno; PRK00077
552531004607	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
552531004608	dimer interface [polypeptide binding]; other site
552531004609	metal binding site [ion binding]; metal-binding site
552531004610	substrate binding pocket [chemical binding]; other site
552531004611	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
552531004612	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
552531004613	dimer interface [polypeptide binding]; other site
552531004614	conserved gate region; other site
552531004615	putative PBP binding loops; other site
552531004616	ABC-ATPase subunit interface; other site
552531004617	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
552531004618	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
552531004619	substrate binding pocket [chemical binding]; other site
552531004620	membrane-bound complex binding site; other site
552531004621	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
552531004622	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
552531004623	Walker A/P-loop; other site
552531004624	ATP binding site [chemical binding]; other site
552531004625	Q-loop/lid; other site
552531004626	ABC transporter signature motif; other site
552531004627	Walker B; other site
552531004628	D-loop; other site
552531004629	H-loop/switch region; other site
552531004630	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
552531004631	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
552531004632	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552531004633	ATP binding site [chemical binding]; other site
552531004634	putative Mg++ binding site [ion binding]; other site
552531004635	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531004636	nucleotide binding region [chemical binding]; other site
552531004637	ATP-binding site [chemical binding]; other site
552531004638	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
552531004639	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
552531004640	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
552531004641	Coenzyme A binding pocket [chemical binding]; other site
552531004642	Uncharacterized conserved protein [Function unknown]; Region: COG1615
552531004643	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
552531004644	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
552531004645	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
552531004646	carbon starvation protein A; Provisional; Region: PRK15015
552531004647	Carbon starvation protein CstA; Region: CstA; pfam02554
552531004648	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
552531004649	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531004650	Walker B; other site
552531004651	D-loop; other site
552531004652	H-loop/switch region; other site
552531004653	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531004654	ABC transporter signature motif; other site
552531004655	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
552531004656	Q-loop/lid; other site
552531004657	ABC transporter signature motif; other site
552531004658	Walker B; other site
552531004659	D-loop; other site
552531004660	H-loop/switch region; other site
552531004661	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
552531004662	MarR family; Region: MarR_2; pfam12802
552531004663	Ubinuclein conserved middle domain; Region: UBN_AB; pfam14075
552531004664	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
552531004665	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
552531004666	Aspartase; Region: Aspartase; cd01357
552531004667	active sites [active]
552531004668	tetramer interface [polypeptide binding]; other site
552531004669	FeoA domain; Region: FeoA; pfam04023
552531004670	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
552531004671	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
552531004672	G1 box; other site
552531004673	GTP/Mg2+ binding site [chemical binding]; other site
552531004674	Switch I region; other site
552531004675	G2 box; other site
552531004676	G3 box; other site
552531004677	Switch II region; other site
552531004678	G4 box; other site
552531004679	G5 box; other site
552531004680	Nucleoside recognition; Region: Gate; pfam07670
552531004681	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
552531004682	Nucleoside recognition; Region: Gate; pfam07670
552531004683	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
552531004684	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
552531004685	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
552531004686	glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534
552531004687	Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128
552531004688	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
552531004689	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
552531004690	putative active site [active]
552531004691	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
552531004692	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
552531004693	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
552531004694	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
552531004695	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
552531004696	SelR domain; Region: SelR; pfam01641
552531004697	methionine sulfoxide reductase B; Provisional; Region: PRK00222
552531004698	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
552531004699	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
552531004700	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
552531004701	Soluble P-type ATPase [General function prediction only]; Region: COG4087
552531004702	Uncharacterized conserved protein [Function unknown]; Region: COG3350
552531004703	classical (c) SDRs; Region: SDR_c; cd05233
552531004704	NAD(P) binding site [chemical binding]; other site
552531004705	active site
552531004706	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
552531004707	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
552531004708	ATP binding site [chemical binding]; other site
552531004709	Mg++ binding site [ion binding]; other site
552531004710	motif III; other site
552531004711	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531004712	nucleotide binding region [chemical binding]; other site
552531004713	ATP-binding site [chemical binding]; other site
552531004714	Predicted membrane protein [Function unknown]; Region: COG2855
552531004715	pyrimidine utilization transport protein G; Region: RutG; TIGR03616
552531004716	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
552531004717	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
552531004718	substrate binding pocket [chemical binding]; other site
552531004719	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
552531004720	GTP-binding protein YchF; Reviewed; Region: PRK09601
552531004721	YchF GTPase; Region: YchF; cd01900
552531004722	G1 box; other site
552531004723	GTP/Mg2+ binding site [chemical binding]; other site
552531004724	Switch I region; other site
552531004725	G2 box; other site
552531004726	Switch II region; other site
552531004727	G3 box; other site
552531004728	G4 box; other site
552531004729	G5 box; other site
552531004730	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
552531004731	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
552531004732	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
552531004733	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
552531004734	Histidine kinase; Region: HisKA_3; pfam07730
552531004735	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552531004736	ATP binding site [chemical binding]; other site
552531004737	Mg2+ binding site [ion binding]; other site
552531004738	G-X-G motif; other site
552531004739	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
552531004740	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552531004741	active site
552531004742	phosphorylation site [posttranslational modification]
552531004743	intermolecular recognition site; other site
552531004744	dimerization interface [polypeptide binding]; other site
552531004745	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
552531004746	DNA binding residues [nucleotide binding]
552531004747	dimerization interface [polypeptide binding]; other site
552531004748	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
552531004749	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
552531004750	FtsX-like permease family; Region: FtsX; pfam02687
552531004751	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
552531004752	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
552531004753	Walker A/P-loop; other site
552531004754	ATP binding site [chemical binding]; other site
552531004755	Q-loop/lid; other site
552531004756	ABC transporter signature motif; other site
552531004757	Walker B; other site
552531004758	D-loop; other site
552531004759	H-loop/switch region; other site
552531004760	potential frameshift: common BLAST hit: gi|241196492|ref|YP_002970047.1| cobalt transport protein
552531004761	Cobalt transport protein; Region: CbiQ; cl00463
552531004762	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
552531004763	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552531004764	Walker A/P-loop; other site
552531004765	ATP binding site [chemical binding]; other site
552531004766	Q-loop/lid; other site
552531004767	ABC transporter signature motif; other site
552531004768	Walker B; other site
552531004769	D-loop; other site
552531004770	H-loop/switch region; other site
552531004771	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
552531004772	Walker A/P-loop; other site
552531004773	ATP binding site [chemical binding]; other site
552531004774	Q-loop/lid; other site
552531004775	ABC transporter signature motif; other site
552531004776	Walker B; other site
552531004777	D-loop; other site
552531004778	H-loop/switch region; other site
552531004779	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
552531004780	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
552531004781	homodimer interface [polypeptide binding]; other site
552531004782	substrate-cofactor binding pocket; other site
552531004783	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531004784	catalytic residue [active]
552531004785	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
552531004786	dimer interface [polypeptide binding]; other site
552531004787	pyridoxal binding site [chemical binding]; other site
552531004788	ATP binding site [chemical binding]; other site
552531004789	hypothetical protein; Provisional; Region: PRK14681
552531004790	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
552531004791	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
552531004792	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531004793	Walker A motif; other site
552531004794	ATP binding site [chemical binding]; other site
552531004795	Walker B motif; other site
552531004796	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
552531004797	DNA protecting protein DprA; Region: dprA; TIGR00732
552531004798	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
552531004799	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205
552531004800	L-aspartate oxidase; Provisional; Region: PRK06175
552531004801	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
552531004802	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
552531004803	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
552531004804	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
552531004805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
552531004806	S-adenosylmethionine binding site [chemical binding]; other site
552531004807	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
552531004808	Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133
552531004809	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
552531004810	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
552531004811	pyridoxal 5'-phosphate binding site [chemical binding]; other site
552531004812	homodimer interface [polypeptide binding]; other site
552531004813	catalytic residue [active]
552531004814	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
552531004815	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
552531004816	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
552531004817	Walker A motif; other site
552531004818	ATP binding site [chemical binding]; other site
552531004819	Walker B motif; other site
552531004820	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
552531004821	ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553
552531004822	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
552531004823	oligomer interface [polypeptide binding]; other site
552531004824	active site residues [active]
552531004825	Clp protease; Region: CLP_protease; pfam00574
552531004826	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
552531004827	oligomer interface [polypeptide binding]; other site
552531004828	active site residues [active]
552531004829	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
552531004830	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
552531004831	putative ion selectivity filter; other site
552531004832	putative pore gating glutamate residue; other site
552531004833	trigger factor; Provisional; Region: tig; PRK01490
552531004834	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
552531004835	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
552531004836	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
552531004837	DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012
552531004838	active site
552531004839	catalytic site [active]
552531004840	substrate binding site [chemical binding]; other site
552531004841	HRDC domain; Region: HRDC; pfam00570
552531004842	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
552531004843	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552531004844	FeS/SAM binding site; other site
552531004845	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
552531004846	Pyruvate formate lyase 1; Region: PFL1; cd01678
552531004847	coenzyme A binding site [chemical binding]; other site
552531004848	active site
552531004849	catalytic residues [active]
552531004850	glycine loop; other site
552531004851	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
552531004852	NAD synthetase; Provisional; Region: PRK13981
552531004853	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
552531004854	multimer interface [polypeptide binding]; other site
552531004855	active site
552531004856	catalytic triad [active]
552531004857	protein interface 1 [polypeptide binding]; other site
552531004858	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
552531004859	homodimer interface [polypeptide binding]; other site
552531004860	NAD binding pocket [chemical binding]; other site
552531004861	ATP binding pocket [chemical binding]; other site
552531004862	Mg binding site [ion binding]; other site
552531004863	active-site loop [active]
552531004864	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
552531004865	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
552531004866	metal binding site [ion binding]; metal-binding site
552531004867	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
552531004868	conserved gate region; other site
552531004869	ABC-ATPase subunit interface; other site
552531004870	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
552531004871	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
552531004872	Walker A/P-loop; other site
552531004873	ATP binding site [chemical binding]; other site
552531004874	Q-loop/lid; other site
552531004875	ABC transporter signature motif; other site
552531004876	Walker B; other site
552531004877	D-loop; other site
552531004878	H-loop/switch region; other site
552531004879	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
552531004880	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
552531004881	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
552531004882	active site
552531004883	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
552531004884	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
552531004885	Zn2+ binding site [ion binding]; other site
552531004886	Mg2+ binding site [ion binding]; other site
552531004887	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
552531004888	synthetase active site [active]
552531004889	NTP binding site [chemical binding]; other site
552531004890	metal binding site [ion binding]; metal-binding site
552531004891	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
552531004892	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
552531004893	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
552531004894	trimer interface [polypeptide binding]; other site
552531004895	active site
552531004896	Domain of unknown function (DUF4193); Region: DUF4193; pfam13834
552531004897	Protein of unknown function (DUF3071); Region: DUF3071; pfam11268
552531004898	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
552531004899	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
552531004900	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
552531004901	CAP-like domain; other site
552531004902	active site
552531004903	primary dimer interface [polypeptide binding]; other site
552531004904	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
552531004905	EamA-like transporter family; Region: EamA; cl17759
552531004906	DEAD-like helicases superfamily; Region: DEXDc; smart00487
552531004907	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
552531004908	ATP binding site [chemical binding]; other site
552531004909	putative Mg++ binding site [ion binding]; other site
552531004910	Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201
552531004911	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
552531004912	nucleotide binding region [chemical binding]; other site
552531004913	ATP-binding site [chemical binding]; other site
552531004914	DEAD/H associated; Region: DEAD_assoc; pfam08494
552531004915	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
552531004916	Major Facilitator Superfamily; Region: MFS_1; pfam07690
552531004917	putative substrate translocation pore; other site
552531004918	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
552531004919	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
552531004920	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
552531004921	ATP binding site [chemical binding]; other site
552531004922	Mg2+ binding site [ion binding]; other site
552531004923	G-X-G motif; other site
552531004924	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
552531004925	anchoring element; other site
552531004926	dimer interface [polypeptide binding]; other site
552531004927	ATP binding site [chemical binding]; other site
552531004928	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
552531004929	active site
552531004930	putative metal-binding site [ion binding]; other site
552531004931	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
552531004932	RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921
552531004933	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
552531004934	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
552531004935	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
552531004936	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
552531004937	DNA binding residues [nucleotide binding]
552531004938	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
552531004939	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
552531004940	substrate binding pocket [chemical binding]; other site
552531004941	chain length determination region; other site
552531004942	substrate-Mg2+ binding site; other site
552531004943	catalytic residues [active]
552531004944	aspartate-rich region 1; other site
552531004945	active site lid residues [active]
552531004946	aspartate-rich region 2; other site
552531004947	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
552531004948	Catalytic domain of Protein Kinases; Region: PKc; cd00180
552531004949	active site
552531004950	ATP binding site [chemical binding]; other site
552531004951	substrate binding site [chemical binding]; other site
552531004952	activation loop (A-loop); other site
552531004953	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552531004954	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552531004955	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
552531004956	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
552531004957	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
552531004958	putative acyl-acceptor binding pocket; other site
552531004959	Short repeat of unknown function (DUF308); Region: DUF308; pfam03729
552531004960	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
552531004961	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
552531004962	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
552531004963	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
552531004964	DEAD/DEAH box helicase; Region: DEAD; pfam00270
552531004965	ATP binding site [chemical binding]; other site
552531004966	putative Mg++ binding site [ion binding]; other site
552531004967	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
552531004968	SEC-C motif; Region: SEC-C; pfam02810
552531004969	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
552531004970	30S subunit binding site; other site
552531004971	RecX family; Region: RecX; pfam02631
552531004972	recombinase A; Provisional; Region: recA; PRK09354
552531004973	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
552531004974	hexamer interface [polypeptide binding]; other site
552531004975	Walker A motif; other site
552531004976	ATP binding site [chemical binding]; other site
552531004977	Walker B motif; other site
552531004978	Protein of unknown function (DUF3046); Region: DUF3046; pfam11248
552531004979	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
552531004980	non-specific DNA binding site [nucleotide binding]; other site
552531004981	salt bridge; other site
552531004982	sequence-specific DNA binding site [nucleotide binding]; other site
552531004983	Competence-damaged protein; Region: CinA; pfam02464
552531004984	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
552531004985	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
552531004986	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
552531004987	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
552531004988	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
552531004989	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
552531004990	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326
552531004991	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
552531004992	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
552531004993	FeS/SAM binding site; other site
552531004994	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
552531004995	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
552531004996	synthetase active site [active]
552531004997	NTP binding site [chemical binding]; other site
552531004998	metal binding site [ion binding]; metal-binding site
552531004999	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
552531005000	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
552531005001	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
552531005002	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
552531005003	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
552531005004	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
552531005005	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
552531005006	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
552531005007	Walker A/P-loop; other site
552531005008	ATP binding site [chemical binding]; other site
552531005009	Q-loop/lid; other site
552531005010	ABC transporter signature motif; other site
552531005011	Walker B; other site
552531005012	D-loop; other site
552531005013	H-loop/switch region; other site
552531005014	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
552531005015	Histidine kinase; Region: HisKA_3; pfam07730
552531005016	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
552531005017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
552531005018	active site
552531005019	phosphorylation site [posttranslational modification]
552531005020	intermolecular recognition site; other site
552531005021	dimerization interface [polypeptide binding]; other site
552531005022	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
552531005023	DNA binding residues [nucleotide binding]
552531005024	dimerization interface [polypeptide binding]; other site
552531005025	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
552531005026	Transposase; Region: DDE_Tnp_ISL3; pfam01610
552531005027	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332
552531005028	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
552531005029	active site
552531005030	catalytic site [active]
552531005031	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941