-- dump date 20140619_002050 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1075106000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1075106000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106000003 Walker A motif; other site 1075106000004 ATP binding site [chemical binding]; other site 1075106000005 Walker B motif; other site 1075106000006 arginine finger; other site 1075106000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1075106000008 DnaA box-binding interface [nucleotide binding]; other site 1075106000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1075106000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1075106000011 putative DNA binding surface [nucleotide binding]; other site 1075106000012 dimer interface [polypeptide binding]; other site 1075106000013 beta-clamp/clamp loader binding surface; other site 1075106000014 beta-clamp/translesion DNA polymerase binding surface; other site 1075106000015 recombination protein F; Reviewed; Region: recF; PRK00064 1075106000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000017 Walker A/P-loop; other site 1075106000018 ATP binding site [chemical binding]; other site 1075106000019 Q-loop/lid; other site 1075106000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000021 ABC transporter signature motif; other site 1075106000022 Walker B; other site 1075106000023 D-loop; other site 1075106000024 H-loop/switch region; other site 1075106000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1075106000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1075106000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106000028 Mg2+ binding site [ion binding]; other site 1075106000029 G-X-G motif; other site 1075106000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1075106000031 anchoring element; other site 1075106000032 dimer interface [polypeptide binding]; other site 1075106000033 ATP binding site [chemical binding]; other site 1075106000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1075106000035 active site 1075106000036 putative metal-binding site [ion binding]; other site 1075106000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1075106000038 DNA gyrase subunit A; Validated; Region: PRK05560 1075106000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1075106000040 CAP-like domain; other site 1075106000041 active site 1075106000042 primary dimer interface [polypeptide binding]; other site 1075106000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1075106000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1075106000050 VanZ like family; Region: VanZ; cl01971 1075106000051 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1075106000052 Haemolysin-III related; Region: HlyIII; pfam03006 1075106000053 glutamate dehydrogenase; Provisional; Region: PRK09414 1075106000054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1075106000055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1075106000056 NAD(P) binding site [chemical binding]; other site 1075106000057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106000059 putative substrate translocation pore; other site 1075106000060 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 1075106000061 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1075106000062 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1075106000063 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1075106000064 Protein of unknown function DUF45; Region: DUF45; pfam01863 1075106000065 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1075106000066 MarR family; Region: MarR_2; pfam12802 1075106000067 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1075106000068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1075106000069 non-specific DNA interactions [nucleotide binding]; other site 1075106000070 DNA binding site [nucleotide binding] 1075106000071 sequence specific DNA binding site [nucleotide binding]; other site 1075106000072 putative cAMP binding site [chemical binding]; other site 1075106000073 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1075106000074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000075 Walker A/P-loop; other site 1075106000076 ATP binding site [chemical binding]; other site 1075106000077 Q-loop/lid; other site 1075106000078 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1075106000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000080 ABC transporter signature motif; other site 1075106000081 Walker B; other site 1075106000082 D-loop; other site 1075106000083 H-loop/switch region; other site 1075106000084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000085 Walker A/P-loop; other site 1075106000086 ATP binding site [chemical binding]; other site 1075106000087 Q-loop/lid; other site 1075106000088 ABC transporter signature motif; other site 1075106000089 Walker B; other site 1075106000090 D-loop; other site 1075106000091 H-loop/switch region; other site 1075106000092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106000093 S-adenosylmethionine binding site [chemical binding]; other site 1075106000094 Predicted flavoprotein [General function prediction only]; Region: COG0431 1075106000095 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1075106000096 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1075106000097 homodimer interface [polypeptide binding]; other site 1075106000098 chemical substrate binding site [chemical binding]; other site 1075106000099 oligomer interface [polypeptide binding]; other site 1075106000100 metal binding site [ion binding]; metal-binding site 1075106000101 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1075106000102 GIY-YIG motif/motif A; other site 1075106000103 active site 1075106000104 catalytic site [active] 1075106000105 Helix-turn-helix domain; Region: HTH_17; pfam12728 1075106000106 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1075106000107 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1075106000108 cofactor binding site; other site 1075106000109 DNA binding site [nucleotide binding] 1075106000110 substrate interaction site [chemical binding]; other site 1075106000111 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1075106000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1075106000113 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 1075106000114 PemK-like protein; Region: PemK; pfam02452 1075106000115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1075106000116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1075106000117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1075106000118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106000119 active site 1075106000120 catalytic tetrad [active] 1075106000121 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1075106000122 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1075106000123 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1075106000124 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1075106000125 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1075106000126 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1075106000127 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106000128 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106000129 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1075106000130 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1075106000131 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1075106000132 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1075106000133 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1075106000134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000135 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106000136 putative substrate translocation pore; other site 1075106000137 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106000138 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1075106000139 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1075106000140 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1075106000141 dimerization interface [polypeptide binding]; other site 1075106000142 DPS ferroxidase diiron center [ion binding]; other site 1075106000143 ion pore; other site 1075106000144 Domain of unknown function DUF21; Region: DUF21; pfam01595 1075106000145 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1075106000146 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1075106000147 Transporter associated domain; Region: CorC_HlyC; smart01091 1075106000148 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1075106000149 active site clefts [active] 1075106000150 zinc binding site [ion binding]; other site 1075106000151 dimer interface [polypeptide binding]; other site 1075106000152 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106000153 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106000154 DNA binding site [nucleotide binding] 1075106000155 domain linker motif; other site 1075106000156 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1075106000157 ligand binding site [chemical binding]; other site 1075106000158 dimerization interface (open form) [polypeptide binding]; other site 1075106000159 dimerization interface (closed form) [polypeptide binding]; other site 1075106000160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000161 Walker A/P-loop; other site 1075106000162 ATP binding site [chemical binding]; other site 1075106000163 ABC transporter; Region: ABC_tran; pfam00005 1075106000164 Q-loop/lid; other site 1075106000165 ABC transporter signature motif; other site 1075106000166 Walker B; other site 1075106000167 D-loop; other site 1075106000168 H-loop/switch region; other site 1075106000169 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106000170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106000171 DNA binding site [nucleotide binding] 1075106000172 domain linker motif; other site 1075106000173 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106000174 ligand binding site [chemical binding]; other site 1075106000175 dimerization interface [polypeptide binding]; other site 1075106000176 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1075106000177 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1075106000178 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1075106000179 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1075106000180 putative N- and C-terminal domain interface [polypeptide binding]; other site 1075106000181 putative active site [active] 1075106000182 MgATP binding site [chemical binding]; other site 1075106000183 catalytic site [active] 1075106000184 metal binding site [ion binding]; metal-binding site 1075106000185 putative carbohydrate binding site [chemical binding]; other site 1075106000186 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1075106000187 intersubunit interface [polypeptide binding]; other site 1075106000188 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1075106000189 active site 1075106000190 Zn2+ binding site [ion binding]; other site 1075106000191 L-arabinose isomerase; Provisional; Region: PRK02929 1075106000192 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1075106000193 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1075106000194 trimer interface [polypeptide binding]; other site 1075106000195 substrate binding site [chemical binding]; other site 1075106000196 Mn binding site [ion binding]; other site 1075106000197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106000198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1075106000199 active site 1075106000200 catalytic tetrad [active] 1075106000201 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1075106000202 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1075106000203 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1075106000204 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1075106000205 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1075106000206 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106000207 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106000208 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1075106000209 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1075106000210 active site 1075106000211 HIGH motif; other site 1075106000212 dimer interface [polypeptide binding]; other site 1075106000213 KMSKS motif; other site 1075106000214 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1075106000215 homodimer interface [polypeptide binding]; other site 1075106000216 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1075106000217 active site pocket [active] 1075106000218 Rhomboid family; Region: Rhomboid; pfam01694 1075106000219 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1075106000220 putative septation inhibitor protein; Reviewed; Region: PRK02251 1075106000221 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1075106000222 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1075106000223 active site 1075106000224 catalytic site [active] 1075106000225 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1075106000226 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1075106000227 glutamine binding [chemical binding]; other site 1075106000228 catalytic triad [active] 1075106000229 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106000230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106000231 active site 1075106000232 ATP binding site [chemical binding]; other site 1075106000233 substrate binding site [chemical binding]; other site 1075106000234 activation loop (A-loop); other site 1075106000235 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106000236 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106000237 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106000238 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106000239 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106000240 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1075106000241 active site 1075106000242 ATP binding site [chemical binding]; other site 1075106000243 substrate binding site [chemical binding]; other site 1075106000244 activation loop (A-loop); other site 1075106000245 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1075106000246 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1075106000247 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1075106000248 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1075106000249 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1075106000250 active site 1075106000251 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106000252 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1075106000253 phosphopeptide binding site; other site 1075106000254 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1075106000255 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106000256 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1075106000257 phosphopeptide binding site; other site 1075106000258 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1075106000259 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1075106000260 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1075106000261 EamA-like transporter family; Region: EamA; pfam00892 1075106000262 EamA-like transporter family; Region: EamA; pfam00892 1075106000263 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1075106000264 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1075106000265 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1075106000266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106000267 S-adenosylmethionine binding site [chemical binding]; other site 1075106000268 Predicted membrane protein [Function unknown]; Region: COG2261 1075106000269 ferredoxin-NADP+ reductase; Region: PLN02852 1075106000270 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1075106000271 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1075106000272 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106000273 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1075106000274 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1075106000275 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1075106000276 protein binding site [polypeptide binding]; other site 1075106000277 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1075106000278 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1075106000279 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1075106000280 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1075106000281 heat shock protein HtpX; Provisional; Region: PRK03072 1075106000282 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1075106000283 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1075106000284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106000286 putative substrate translocation pore; other site 1075106000287 RelB antitoxin; Region: RelB; cl01171 1075106000288 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1075106000289 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1075106000290 DNA binding site [nucleotide binding] 1075106000291 active site 1075106000292 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1075106000293 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1075106000294 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1075106000295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1075106000296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1075106000297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1075106000298 dimerization interface [polypeptide binding]; other site 1075106000299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106000300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1075106000301 active site 1075106000302 catalytic tetrad [active] 1075106000303 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1075106000304 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1075106000305 FAD binding pocket [chemical binding]; other site 1075106000306 conserved FAD binding motif [chemical binding]; other site 1075106000307 phosphate binding motif [ion binding]; other site 1075106000308 beta-alpha-beta structure motif; other site 1075106000309 NAD binding pocket [chemical binding]; other site 1075106000310 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1075106000311 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1075106000312 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1075106000313 DNA binding residues [nucleotide binding] 1075106000314 putative dimer interface [polypeptide binding]; other site 1075106000315 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1075106000316 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1075106000317 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1075106000318 NAD(P) binding site [chemical binding]; other site 1075106000319 putative active site [active] 1075106000320 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1075106000321 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1075106000322 catalytic Zn binding site [ion binding]; other site 1075106000323 NAD(P) binding site [chemical binding]; other site 1075106000324 structural Zn binding site [ion binding]; other site 1075106000325 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1075106000326 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1075106000327 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1075106000328 dimerization interface [polypeptide binding]; other site 1075106000329 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1075106000330 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1075106000331 NodB motif; other site 1075106000332 active site 1075106000333 catalytic site [active] 1075106000334 metal binding site [ion binding]; metal-binding site 1075106000335 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1075106000336 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1075106000337 active site 1075106000338 intersubunit interface [polypeptide binding]; other site 1075106000339 zinc binding site [ion binding]; other site 1075106000340 Na+ binding site [ion binding]; other site 1075106000341 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1075106000342 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1075106000343 GDP-binding site [chemical binding]; other site 1075106000344 ACT binding site; other site 1075106000345 IMP binding site; other site 1075106000346 CrcB-like protein; Region: CRCB; pfam02537 1075106000347 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1075106000348 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1075106000349 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1075106000350 TM-ABC transporter signature motif; other site 1075106000351 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1075106000352 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1075106000353 TM-ABC transporter signature motif; other site 1075106000354 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1075106000355 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1075106000356 Walker A/P-loop; other site 1075106000357 ATP binding site [chemical binding]; other site 1075106000358 Q-loop/lid; other site 1075106000359 ABC transporter signature motif; other site 1075106000360 Walker B; other site 1075106000361 D-loop; other site 1075106000362 H-loop/switch region; other site 1075106000363 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1075106000364 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1075106000365 Walker A/P-loop; other site 1075106000366 ATP binding site [chemical binding]; other site 1075106000367 Q-loop/lid; other site 1075106000368 ABC transporter signature motif; other site 1075106000369 Walker B; other site 1075106000370 D-loop; other site 1075106000371 H-loop/switch region; other site 1075106000372 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1075106000373 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1075106000374 ligand binding site [chemical binding]; other site 1075106000375 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106000376 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106000377 DNA binding site [nucleotide binding] 1075106000378 domain linker motif; other site 1075106000379 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1075106000380 sucrose phosphorylase; Provisional; Region: PRK13840 1075106000381 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1075106000382 active site 1075106000383 homodimer interface [polypeptide binding]; other site 1075106000384 catalytic site [active] 1075106000385 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 1075106000386 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000387 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106000388 putative substrate translocation pore; other site 1075106000389 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1075106000390 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1075106000391 ligand binding site [chemical binding]; other site 1075106000392 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1075106000393 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1075106000394 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1075106000395 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1075106000396 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 1075106000397 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1075106000398 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1075106000399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1075106000400 metabolite-proton symporter; Region: 2A0106; TIGR00883 1075106000401 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000402 putative substrate translocation pore; other site 1075106000403 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1075106000404 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1075106000405 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1075106000406 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1075106000407 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1075106000408 active site 1075106000409 catalytic triad [active] 1075106000410 oxyanion hole [active] 1075106000411 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1075106000412 beta-galactosidase; Region: BGL; TIGR03356 1075106000413 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106000414 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106000415 DNA binding site [nucleotide binding] 1075106000416 domain linker motif; other site 1075106000417 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106000418 ligand binding site [chemical binding]; other site 1075106000419 dimerization interface [polypeptide binding]; other site 1075106000420 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1075106000421 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1075106000422 putative active cleft [active] 1075106000423 dimerization interface [polypeptide binding]; other site 1075106000424 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1075106000425 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000426 Walker A/P-loop; other site 1075106000427 ATP binding site [chemical binding]; other site 1075106000428 Q-loop/lid; other site 1075106000429 ABC transporter signature motif; other site 1075106000430 Walker B; other site 1075106000431 D-loop; other site 1075106000432 H-loop/switch region; other site 1075106000433 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1075106000434 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1075106000435 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106000436 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1075106000437 Walker A/P-loop; other site 1075106000438 ATP binding site [chemical binding]; other site 1075106000439 Q-loop/lid; other site 1075106000440 ABC transporter signature motif; other site 1075106000441 Walker B; other site 1075106000442 D-loop; other site 1075106000443 H-loop/switch region; other site 1075106000444 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106000445 FtsX-like permease family; Region: FtsX; pfam02687 1075106000446 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1075106000447 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1075106000448 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106000449 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1075106000450 FtsX-like permease family; Region: FtsX; pfam02687 1075106000451 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000452 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106000453 ABC transporter signature motif; other site 1075106000454 Walker B; other site 1075106000455 D-loop; other site 1075106000456 H-loop/switch region; other site 1075106000457 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1075106000458 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106000459 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1075106000460 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000461 Walker A/P-loop; other site 1075106000462 ATP binding site [chemical binding]; other site 1075106000463 Q-loop/lid; other site 1075106000464 ABC transporter signature motif; other site 1075106000465 Walker B; other site 1075106000466 D-loop; other site 1075106000467 H-loop/switch region; other site 1075106000468 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106000469 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1075106000470 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1075106000471 Walker A/P-loop; other site 1075106000472 ATP binding site [chemical binding]; other site 1075106000473 Q-loop/lid; other site 1075106000474 ABC transporter signature motif; other site 1075106000475 Walker B; other site 1075106000476 D-loop; other site 1075106000477 H-loop/switch region; other site 1075106000478 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1075106000479 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1075106000480 NodB motif; other site 1075106000481 active site 1075106000482 catalytic site [active] 1075106000483 metal binding site [ion binding]; metal-binding site 1075106000484 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1075106000485 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1075106000486 active site 1075106000487 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1075106000488 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1075106000489 active site 1075106000490 substrate binding site [chemical binding]; other site 1075106000491 trimer interface [polypeptide binding]; other site 1075106000492 CoA binding site [chemical binding]; other site 1075106000493 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1075106000494 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1075106000495 ligand binding site [chemical binding]; other site 1075106000496 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106000497 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1075106000498 Predicted membrane protein [Function unknown]; Region: COG1511 1075106000499 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1075106000500 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1075106000501 Predicted membrane protein [Function unknown]; Region: COG1511 1075106000502 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1075106000503 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1075106000504 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 1075106000505 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1075106000506 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1075106000507 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106000508 Walker A/P-loop; other site 1075106000509 ATP binding site [chemical binding]; other site 1075106000510 Q-loop/lid; other site 1075106000511 ABC transporter signature motif; other site 1075106000512 Walker B; other site 1075106000513 D-loop; other site 1075106000514 H-loop/switch region; other site 1075106000515 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106000516 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1075106000517 Walker A/P-loop; other site 1075106000518 ATP binding site [chemical binding]; other site 1075106000519 Q-loop/lid; other site 1075106000520 ABC transporter signature motif; other site 1075106000521 Walker B; other site 1075106000522 D-loop; other site 1075106000523 H-loop/switch region; other site 1075106000524 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1075106000525 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1075106000526 intersubunit interface [polypeptide binding]; other site 1075106000527 YodA lipocalin-like domain; Region: YodA; cl01365 1075106000528 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1075106000529 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1075106000530 active site 1075106000531 nucleophile elbow; other site 1075106000532 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106000533 Peptidase family C69; Region: Peptidase_C69; pfam03577 1075106000534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106000535 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1075106000536 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1075106000537 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1075106000538 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1075106000539 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1075106000540 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1075106000541 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1075106000542 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1075106000543 metal binding triad; other site 1075106000544 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1075106000545 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1075106000546 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1075106000547 sequence-specific DNA binding site [nucleotide binding]; other site 1075106000548 salt bridge; other site 1075106000549 replicative DNA helicase; Region: DnaB; TIGR00665 1075106000550 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1075106000551 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1075106000552 Walker A motif; other site 1075106000553 ATP binding site [chemical binding]; other site 1075106000554 Walker B motif; other site 1075106000555 DNA binding loops [nucleotide binding] 1075106000556 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106000557 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1075106000558 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1075106000559 catalytic triad [active] 1075106000560 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1075106000561 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1075106000562 ABC1 family; Region: ABC1; cl17513 1075106000563 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1075106000564 active site 1075106000565 catalytic site [active] 1075106000566 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1075106000567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106000568 active site 1075106000569 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1075106000570 active site 1075106000571 Ap6A binding site [chemical binding]; other site 1075106000572 nudix motif; other site 1075106000573 metal binding site [ion binding]; metal-binding site 1075106000574 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106000575 catalytic core [active] 1075106000576 polyphosphate kinase; Provisional; Region: PRK05443 1075106000577 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1075106000578 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1075106000579 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1075106000580 putative domain interface [polypeptide binding]; other site 1075106000581 putative active site [active] 1075106000582 catalytic site [active] 1075106000583 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1075106000584 putative domain interface [polypeptide binding]; other site 1075106000585 putative active site [active] 1075106000586 catalytic site [active] 1075106000587 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1075106000588 Type II/IV secretion system protein; Region: T2SE; pfam00437 1075106000589 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1075106000590 Walker B motif; other site 1075106000591 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1075106000592 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1075106000593 TadE-like protein; Region: TadE; pfam07811 1075106000594 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1075106000595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106000596 Walker A motif; other site 1075106000597 ATP binding site [chemical binding]; other site 1075106000598 Walker B motif; other site 1075106000599 arginine finger; other site 1075106000600 recombination protein RecR; Reviewed; Region: recR; PRK00076 1075106000601 RecR protein; Region: RecR; pfam02132 1075106000602 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1075106000603 putative active site [active] 1075106000604 putative metal-binding site [ion binding]; other site 1075106000605 tetramer interface [polypeptide binding]; other site 1075106000606 aspartate kinase; Reviewed; Region: PRK06635 1075106000607 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1075106000608 putative nucleotide binding site [chemical binding]; other site 1075106000609 putative catalytic residues [active] 1075106000610 putative Mg ion binding site [ion binding]; other site 1075106000611 putative aspartate binding site [chemical binding]; other site 1075106000612 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1075106000613 putative allosteric regulatory site; other site 1075106000614 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1075106000615 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1075106000616 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1075106000617 2-isopropylmalate synthase; Validated; Region: PRK03739 1075106000618 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1075106000619 active site 1075106000620 catalytic residues [active] 1075106000621 metal binding site [ion binding]; metal-binding site 1075106000622 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1075106000623 Transglycosylase; Region: Transgly; pfam00912 1075106000624 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1075106000625 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1075106000626 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1075106000627 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1075106000628 PAP2 superfamily; Region: PAP2; pfam01569 1075106000629 active site 1075106000630 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1075106000631 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1075106000632 active site 1075106000633 interdomain interaction site; other site 1075106000634 putative metal-binding site [ion binding]; other site 1075106000635 nucleotide binding site [chemical binding]; other site 1075106000636 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1075106000637 domain I; other site 1075106000638 phosphate binding site [ion binding]; other site 1075106000639 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1075106000640 domain II; other site 1075106000641 domain III; other site 1075106000642 nucleotide binding site [chemical binding]; other site 1075106000643 DNA binding groove [nucleotide binding] 1075106000644 catalytic site [active] 1075106000645 domain IV; other site 1075106000646 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1075106000647 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1075106000648 thymidylate kinase; Validated; Region: tmk; PRK00698 1075106000649 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1075106000650 TMP-binding site; other site 1075106000651 ATP-binding site [chemical binding]; other site 1075106000652 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1075106000653 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1075106000654 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1075106000655 substrate binding site [chemical binding]; other site 1075106000656 Peptidase family C69; Region: Peptidase_C69; pfam03577 1075106000657 Peptidase family C69; Region: Peptidase_C69; pfam03577 1075106000658 AAA domain; Region: AAA_14; pfam13173 1075106000659 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1075106000660 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1075106000661 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 1075106000662 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1075106000663 putative active site [active] 1075106000664 Predicted membrane protein [Function unknown]; Region: COG2246 1075106000665 GtrA-like protein; Region: GtrA; pfam04138 1075106000666 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106000667 catalytic core [active] 1075106000668 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106000669 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106000670 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106000671 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106000672 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1075106000673 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1075106000674 active site 1075106000675 HIGH motif; other site 1075106000676 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1075106000677 active site 1075106000678 KMSKS motif; other site 1075106000679 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1075106000680 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1075106000681 putative active site [active] 1075106000682 putative metal binding site [ion binding]; other site 1075106000683 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1075106000684 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1075106000685 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1075106000686 Bacterial transcriptional regulator; Region: IclR; pfam01614 1075106000687 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1075106000688 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1075106000689 substrate binding site [chemical binding]; other site 1075106000690 ligand binding site [chemical binding]; other site 1075106000691 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1075106000692 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1075106000693 substrate binding site [chemical binding]; other site 1075106000694 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1075106000695 AsnC family; Region: AsnC_trans_reg; pfam01037 1075106000696 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1075106000697 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1075106000698 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1075106000699 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1075106000700 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1075106000701 hinge; other site 1075106000702 active site 1075106000703 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1075106000704 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1075106000705 putative acyl-acceptor binding pocket; other site 1075106000706 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1075106000707 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1075106000708 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1075106000709 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1075106000710 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1075106000711 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1075106000712 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1075106000713 CAAX protease self-immunity; Region: Abi; pfam02517 1075106000714 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1075106000715 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1075106000716 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106000717 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1075106000718 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1075106000719 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1075106000720 nucleophilic elbow; other site 1075106000721 catalytic triad; other site 1075106000722 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1075106000723 Predicted membrane protein [Function unknown]; Region: COG4905 1075106000724 aspartate aminotransferase; Provisional; Region: PRK06836 1075106000725 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106000726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106000727 homodimer interface [polypeptide binding]; other site 1075106000728 catalytic residue [active] 1075106000729 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1075106000730 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1075106000731 binding surface 1075106000732 TPR motif; other site 1075106000733 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1075106000734 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1075106000735 substrate binding site [chemical binding]; other site 1075106000736 ATP binding site [chemical binding]; other site 1075106000737 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1075106000738 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1075106000739 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1075106000740 ssDNA binding site; other site 1075106000741 generic binding surface II; other site 1075106000742 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106000743 ATP binding site [chemical binding]; other site 1075106000744 putative Mg++ binding site [ion binding]; other site 1075106000745 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106000746 nucleotide binding region [chemical binding]; other site 1075106000747 ATP-binding site [chemical binding]; other site 1075106000748 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1075106000749 metal ion-dependent adhesion site (MIDAS); other site 1075106000750 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1075106000751 T surface-antigen of pili; Region: FctA; pfam12892 1075106000752 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1075106000753 T surface-antigen of pili; Region: FctA; pfam12892 1075106000754 T surface-antigen of pili; Region: FctA; pfam12892 1075106000755 T surface-antigen of pili; Region: FctA; pfam12892 1075106000756 T surface-antigen of pili; Region: FctA; pfam12892 1075106000757 T surface-antigen of pili; Region: FctA; pfam12892 1075106000758 T surface-antigen of pili; Region: FctA; pfam12892 1075106000759 T surface-antigen of pili; Region: FctA; pfam12892 1075106000760 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1075106000761 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1075106000762 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106000763 S-adenosylmethionine binding site [chemical binding]; other site 1075106000764 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1075106000765 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1075106000766 RimM N-terminal domain; Region: RimM; pfam01782 1075106000767 PRC-barrel domain; Region: PRC; pfam05239 1075106000768 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1075106000769 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1075106000770 G-X-X-G motif; other site 1075106000771 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1075106000772 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1075106000773 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1075106000774 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1075106000775 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1075106000776 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1075106000777 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1075106000778 putative catalytic site [active] 1075106000779 putative metal binding site [ion binding]; other site 1075106000780 putative phosphate binding site [ion binding]; other site 1075106000781 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1075106000782 putative catalytic site [active] 1075106000783 putative phosphate binding site [ion binding]; other site 1075106000784 putative metal binding site [ion binding]; other site 1075106000785 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1075106000786 Cation efflux family; Region: Cation_efflux; pfam01545 1075106000787 signal recognition particle protein; Provisional; Region: PRK10867 1075106000788 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1075106000789 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1075106000790 P loop; other site 1075106000791 GTP binding site [chemical binding]; other site 1075106000792 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1075106000793 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1075106000794 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106000795 active site 1075106000796 HIGH motif; other site 1075106000797 nucleotide binding site [chemical binding]; other site 1075106000798 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1075106000799 KMSKS motif; other site 1075106000800 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1075106000801 tRNA binding surface [nucleotide binding]; other site 1075106000802 anticodon binding site; other site 1075106000803 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1075106000804 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106000805 ABC transporter; Region: ABC_tran_2; pfam12848 1075106000806 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1075106000807 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1075106000808 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1075106000809 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1075106000810 catalytic triad [active] 1075106000811 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1075106000812 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1075106000813 putative valine binding site [chemical binding]; other site 1075106000814 dimer interface [polypeptide binding]; other site 1075106000815 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1075106000816 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1075106000817 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1075106000818 PYR/PP interface [polypeptide binding]; other site 1075106000819 dimer interface [polypeptide binding]; other site 1075106000820 TPP binding site [chemical binding]; other site 1075106000821 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1075106000822 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1075106000823 TPP-binding site [chemical binding]; other site 1075106000824 dimer interface [polypeptide binding]; other site 1075106000825 ribonuclease III; Reviewed; Region: rnc; PRK00102 1075106000826 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1075106000827 dimerization interface [polypeptide binding]; other site 1075106000828 active site 1075106000829 metal binding site [ion binding]; metal-binding site 1075106000830 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1075106000831 dsRNA binding site [nucleotide binding]; other site 1075106000832 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1075106000833 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1075106000834 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1075106000835 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1075106000836 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1075106000837 active site 1075106000838 (T/H)XGH motif; other site 1075106000839 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1075106000840 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106000841 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1075106000842 active site 1075106000843 catalytic tetrad [active] 1075106000844 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1075106000845 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1075106000846 active site 1075106000847 ribonuclease PH; Reviewed; Region: rph; PRK00173 1075106000848 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1075106000849 hexamer interface [polypeptide binding]; other site 1075106000850 active site 1075106000851 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1075106000852 active site 1075106000853 dimerization interface [polypeptide binding]; other site 1075106000854 FemAB family; Region: FemAB; pfam02388 1075106000855 Membrane transport protein; Region: Mem_trans; cl09117 1075106000856 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1075106000857 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1075106000858 Substrate binding site; other site 1075106000859 Cupin domain; Region: Cupin_2; cl17218 1075106000860 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1075106000861 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1075106000862 active site 1075106000863 dimer interface [polypeptide binding]; other site 1075106000864 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1075106000865 dimer interface [polypeptide binding]; other site 1075106000866 active site 1075106000867 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1075106000868 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1075106000869 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1075106000870 Catalytic site [active] 1075106000871 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1075106000872 RNA/DNA hybrid binding site [nucleotide binding]; other site 1075106000873 active site 1075106000874 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1075106000875 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1075106000876 Walker A/P-loop; other site 1075106000877 ATP binding site [chemical binding]; other site 1075106000878 Q-loop/lid; other site 1075106000879 ABC transporter signature motif; other site 1075106000880 Walker B; other site 1075106000881 D-loop; other site 1075106000882 H-loop/switch region; other site 1075106000883 FtsX-like permease family; Region: FtsX; pfam02687 1075106000884 Predicted permeases [General function prediction only]; Region: COG0679 1075106000885 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1075106000886 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1075106000887 metal binding site [ion binding]; metal-binding site 1075106000888 putative dimer interface [polypeptide binding]; other site 1075106000889 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1075106000890 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1075106000891 homodimer interface [polypeptide binding]; other site 1075106000892 oligonucleotide binding site [chemical binding]; other site 1075106000893 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1075106000894 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1075106000895 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1075106000896 GTP1/OBG; Region: GTP1_OBG; pfam01018 1075106000897 Obg GTPase; Region: Obg; cd01898 1075106000898 G1 box; other site 1075106000899 GTP/Mg2+ binding site [chemical binding]; other site 1075106000900 Switch I region; other site 1075106000901 G2 box; other site 1075106000902 G3 box; other site 1075106000903 Switch II region; other site 1075106000904 G4 box; other site 1075106000905 G5 box; other site 1075106000906 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1075106000907 gamma-glutamyl kinase; Provisional; Region: PRK05429 1075106000908 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1075106000909 nucleotide binding site [chemical binding]; other site 1075106000910 homotetrameric interface [polypeptide binding]; other site 1075106000911 putative phosphate binding site [ion binding]; other site 1075106000912 putative allosteric binding site; other site 1075106000913 PUA domain; Region: PUA; pfam01472 1075106000914 aspartate aminotransferase; Provisional; Region: PRK05764 1075106000915 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106000916 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106000917 homodimer interface [polypeptide binding]; other site 1075106000918 catalytic residue [active] 1075106000919 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1075106000920 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1075106000921 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1075106000922 putative homodimer interface [polypeptide binding]; other site 1075106000923 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1075106000924 heterodimer interface [polypeptide binding]; other site 1075106000925 homodimer interface [polypeptide binding]; other site 1075106000926 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1075106000927 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1075106000928 23S rRNA interface [nucleotide binding]; other site 1075106000929 L7/L12 interface [polypeptide binding]; other site 1075106000930 putative thiostrepton binding site; other site 1075106000931 L25 interface [polypeptide binding]; other site 1075106000932 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1075106000933 mRNA/rRNA interface [nucleotide binding]; other site 1075106000934 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1075106000935 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1075106000936 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1075106000937 BioY family; Region: BioY; pfam02632 1075106000938 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1075106000939 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1075106000940 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1075106000941 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1075106000942 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1075106000943 carboxyltransferase (CT) interaction site; other site 1075106000944 biotinylation site [posttranslational modification]; other site 1075106000945 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1075106000946 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1075106000947 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1075106000948 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1075106000949 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1075106000950 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1075106000951 FMN binding site [chemical binding]; other site 1075106000952 substrate binding site [chemical binding]; other site 1075106000953 putative catalytic residue [active] 1075106000954 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1075106000955 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1075106000956 active site 2 [active] 1075106000957 active site 1 [active] 1075106000958 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1075106000959 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1075106000960 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1075106000961 putative NAD(P) binding site [chemical binding]; other site 1075106000962 active site 1075106000963 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1075106000964 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1075106000965 active site 1075106000966 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1075106000967 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1075106000968 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1075106000969 NAD binding site [chemical binding]; other site 1075106000970 dimer interface [polypeptide binding]; other site 1075106000971 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106000972 substrate binding site [chemical binding]; other site 1075106000973 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1075106000974 16S/18S rRNA binding site [nucleotide binding]; other site 1075106000975 S13e-L30e interaction site [polypeptide binding]; other site 1075106000976 25S rRNA binding site [nucleotide binding]; other site 1075106000977 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1075106000978 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1075106000979 oligomer interface [polypeptide binding]; other site 1075106000980 RNA binding site [nucleotide binding]; other site 1075106000981 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1075106000982 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1075106000983 RNase E interface [polypeptide binding]; other site 1075106000984 trimer interface [polypeptide binding]; other site 1075106000985 active site 1075106000986 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1075106000987 putative nucleic acid binding region [nucleotide binding]; other site 1075106000988 G-X-X-G motif; other site 1075106000989 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1075106000990 RNA binding site [nucleotide binding]; other site 1075106000991 domain interface; other site 1075106000992 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1075106000993 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1075106000994 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1075106000995 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1075106000996 dimer interface [polypeptide binding]; other site 1075106000997 putative radical transfer pathway; other site 1075106000998 diiron center [ion binding]; other site 1075106000999 tyrosyl radical; other site 1075106001000 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1075106001001 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1075106001002 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1075106001003 active site 1075106001004 dimer interface [polypeptide binding]; other site 1075106001005 catalytic residues [active] 1075106001006 effector binding site; other site 1075106001007 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1075106001008 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1075106001009 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1075106001010 catalytic residues [active] 1075106001011 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106001012 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1075106001013 active site 1075106001014 catalytic tetrad [active] 1075106001015 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1075106001016 Peptidase family U32; Region: Peptidase_U32; pfam01136 1075106001017 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1075106001018 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1075106001019 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1075106001020 substrate binding site; other site 1075106001021 dimer interface; other site 1075106001022 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1075106001023 putative substrate binding pocket [chemical binding]; other site 1075106001024 AC domain interface; other site 1075106001025 catalytic triad [active] 1075106001026 AB domain interface; other site 1075106001027 interchain disulfide; other site 1075106001028 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1075106001029 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1075106001030 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1075106001031 trimer interface [polypeptide binding]; other site 1075106001032 active site 1075106001033 G bulge; other site 1075106001034 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1075106001035 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1075106001036 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1075106001037 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1075106001038 catalytic triad [active] 1075106001039 catalytic triad [active] 1075106001040 oxyanion hole [active] 1075106001041 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1075106001042 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1075106001043 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1075106001044 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1075106001045 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1075106001046 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1075106001047 dimer interface [polypeptide binding]; other site 1075106001048 phosphorylation site [posttranslational modification] 1075106001049 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106001050 ATP binding site [chemical binding]; other site 1075106001051 Mg2+ binding site [ion binding]; other site 1075106001052 G-X-G motif; other site 1075106001053 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1075106001054 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106001055 active site 1075106001056 phosphorylation site [posttranslational modification] 1075106001057 intermolecular recognition site; other site 1075106001058 dimerization interface [polypeptide binding]; other site 1075106001059 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1075106001060 DNA binding site [nucleotide binding] 1075106001061 PBP superfamily domain; Region: PBP_like_2; cl17296 1075106001062 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1075106001063 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001064 dimer interface [polypeptide binding]; other site 1075106001065 conserved gate region; other site 1075106001066 putative PBP binding loops; other site 1075106001067 ABC-ATPase subunit interface; other site 1075106001068 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1075106001069 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001070 dimer interface [polypeptide binding]; other site 1075106001071 conserved gate region; other site 1075106001072 putative PBP binding loops; other site 1075106001073 ABC-ATPase subunit interface; other site 1075106001074 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1075106001075 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1075106001076 Walker A/P-loop; other site 1075106001077 ATP binding site [chemical binding]; other site 1075106001078 Q-loop/lid; other site 1075106001079 ABC transporter signature motif; other site 1075106001080 Walker B; other site 1075106001081 D-loop; other site 1075106001082 H-loop/switch region; other site 1075106001083 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1075106001084 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1075106001085 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1075106001086 intersubunit interface [polypeptide binding]; other site 1075106001087 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1075106001088 23S rRNA interface [nucleotide binding]; other site 1075106001089 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1075106001090 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1075106001091 peripheral dimer interface [polypeptide binding]; other site 1075106001092 core dimer interface [polypeptide binding]; other site 1075106001093 L10 interface [polypeptide binding]; other site 1075106001094 L11 interface [polypeptide binding]; other site 1075106001095 putative EF-Tu interaction site [polypeptide binding]; other site 1075106001096 putative EF-G interaction site [polypeptide binding]; other site 1075106001097 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106001098 phosphopeptide binding site; other site 1075106001099 Part of AAA domain; Region: AAA_19; pfam13245 1075106001100 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1075106001101 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1075106001102 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1075106001103 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1075106001104 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1075106001105 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1075106001106 Coenzyme A binding pocket [chemical binding]; other site 1075106001107 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1075106001108 oligomerisation interface [polypeptide binding]; other site 1075106001109 mobile loop; other site 1075106001110 roof hairpin; other site 1075106001111 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1075106001112 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1075106001113 FAD binding domain; Region: FAD_binding_4; pfam01565 1075106001114 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1075106001115 amino acid transporter; Region: 2A0306; TIGR00909 1075106001116 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1075106001117 Ferredoxin [Energy production and conversion]; Region: COG1146 1075106001118 4Fe-4S binding domain; Region: Fer4; pfam00037 1075106001119 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1075106001120 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106001121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001122 homodimer interface [polypeptide binding]; other site 1075106001123 catalytic residue [active] 1075106001124 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1075106001125 active site 1075106001126 DNA polymerase IV; Validated; Region: PRK02406 1075106001127 DNA binding site [nucleotide binding] 1075106001128 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1075106001129 dimerization interface [polypeptide binding]; other site 1075106001130 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1075106001131 NAD binding site [chemical binding]; other site 1075106001132 ligand binding site [chemical binding]; other site 1075106001133 catalytic site [active] 1075106001134 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1075106001135 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1075106001136 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1075106001137 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1075106001138 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1075106001139 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1075106001140 23S rRNA interface [nucleotide binding]; other site 1075106001141 L3 interface [polypeptide binding]; other site 1075106001142 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1075106001143 pullulanase, type I; Region: pulA_typeI; TIGR02104 1075106001144 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1075106001145 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1075106001146 active site 1075106001147 catalytic site [active] 1075106001148 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1075106001149 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1075106001150 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1075106001151 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1075106001152 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1075106001153 putative catalytic cysteine [active] 1075106001154 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1075106001155 putative active site [active] 1075106001156 metal binding site [ion binding]; metal-binding site 1075106001157 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1075106001158 YwiC-like protein; Region: YwiC; pfam14256 1075106001159 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1075106001160 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1075106001161 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1075106001162 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1075106001163 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1075106001164 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1075106001165 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1075106001166 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1075106001167 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1075106001168 putative translocon binding site; other site 1075106001169 protein-rRNA interface [nucleotide binding]; other site 1075106001170 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1075106001171 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1075106001172 G-X-X-G motif; other site 1075106001173 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1075106001174 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1075106001175 23S rRNA interface [nucleotide binding]; other site 1075106001176 5S rRNA interface [nucleotide binding]; other site 1075106001177 putative antibiotic binding site [chemical binding]; other site 1075106001178 L25 interface [polypeptide binding]; other site 1075106001179 L27 interface [polypeptide binding]; other site 1075106001180 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1075106001181 23S rRNA interface [nucleotide binding]; other site 1075106001182 putative translocon interaction site; other site 1075106001183 signal recognition particle (SRP54) interaction site; other site 1075106001184 L23 interface [polypeptide binding]; other site 1075106001185 trigger factor interaction site; other site 1075106001186 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1075106001187 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1075106001188 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1075106001189 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1075106001190 RNA binding site [nucleotide binding]; other site 1075106001191 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1075106001192 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1075106001193 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1075106001194 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1075106001195 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1075106001196 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1075106001197 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1075106001198 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1075106001199 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1075106001200 23S rRNA interface [nucleotide binding]; other site 1075106001201 L21e interface [polypeptide binding]; other site 1075106001202 5S rRNA interface [nucleotide binding]; other site 1075106001203 L27 interface [polypeptide binding]; other site 1075106001204 L5 interface [polypeptide binding]; other site 1075106001205 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1075106001206 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1075106001207 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1075106001208 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1075106001209 23S rRNA binding site [nucleotide binding]; other site 1075106001210 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1075106001211 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1075106001212 SecY translocase; Region: SecY; pfam00344 1075106001213 adenylate kinase; Reviewed; Region: adk; PRK00279 1075106001214 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1075106001215 AMP-binding site [chemical binding]; other site 1075106001216 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1075106001217 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1075106001218 rRNA binding site [nucleotide binding]; other site 1075106001219 predicted 30S ribosome binding site; other site 1075106001220 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1075106001221 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1075106001222 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1075106001223 30S ribosomal protein S11; Validated; Region: PRK05309 1075106001224 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1075106001225 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1075106001226 alphaNTD homodimer interface [polypeptide binding]; other site 1075106001227 alphaNTD - beta interaction site [polypeptide binding]; other site 1075106001228 alphaNTD - beta' interaction site [polypeptide binding]; other site 1075106001229 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1075106001230 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1075106001231 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1075106001232 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1075106001233 dimerization interface 3.5A [polypeptide binding]; other site 1075106001234 active site 1075106001235 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1075106001236 NusA N-terminal domain; Region: NusA_N; pfam08529 1075106001237 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1075106001238 RNA binding site [nucleotide binding]; other site 1075106001239 homodimer interface [polypeptide binding]; other site 1075106001240 NusA-like KH domain; Region: KH_5; pfam13184 1075106001241 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1075106001242 G-X-X-G motif; other site 1075106001243 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1075106001244 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1075106001245 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1075106001246 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1075106001247 G1 box; other site 1075106001248 putative GEF interaction site [polypeptide binding]; other site 1075106001249 GTP/Mg2+ binding site [chemical binding]; other site 1075106001250 Switch I region; other site 1075106001251 G2 box; other site 1075106001252 G3 box; other site 1075106001253 Switch II region; other site 1075106001254 G4 box; other site 1075106001255 G5 box; other site 1075106001256 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1075106001257 Translation-initiation factor 2; Region: IF-2; pfam11987 1075106001258 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1075106001259 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1075106001260 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1075106001261 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1075106001262 RNA binding site [nucleotide binding]; other site 1075106001263 active site 1075106001264 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1075106001265 FAD synthetase; Region: FAD_syn; pfam06574 1075106001266 active site 1075106001267 nucleotide binding site [chemical binding]; other site 1075106001268 HIGH motif; other site 1075106001269 KMSKS motif; other site 1075106001270 Riboflavin kinase; Region: Flavokinase; smart00904 1075106001271 DNA repair protein RadA; Provisional; Region: PRK11823 1075106001272 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1075106001273 Walker A motif; other site 1075106001274 ATP binding site [chemical binding]; other site 1075106001275 Walker B motif; other site 1075106001276 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1075106001277 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1075106001278 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106001279 active site 1075106001280 dimer interface [polypeptide binding]; other site 1075106001281 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1075106001282 RNA/DNA hybrid binding site [nucleotide binding]; other site 1075106001283 active site 1075106001284 seryl-tRNA synthetase; Provisional; Region: PRK05431 1075106001285 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1075106001286 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1075106001287 dimer interface [polypeptide binding]; other site 1075106001288 active site 1075106001289 motif 1; other site 1075106001290 motif 2; other site 1075106001291 motif 3; other site 1075106001292 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1075106001293 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1075106001294 phosphoglucomutase; Validated; Region: PRK07564 1075106001295 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1075106001296 active site 1075106001297 substrate binding site [chemical binding]; other site 1075106001298 metal binding site [ion binding]; metal-binding site 1075106001299 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1075106001300 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 1075106001301 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1075106001302 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1075106001303 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1075106001304 binding surface 1075106001305 TPR motif; other site 1075106001306 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1075106001307 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106001308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106001309 active site 1075106001310 phosphorylation site [posttranslational modification] 1075106001311 intermolecular recognition site; other site 1075106001312 dimerization interface [polypeptide binding]; other site 1075106001313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106001314 DNA binding residues [nucleotide binding] 1075106001315 dimerization interface [polypeptide binding]; other site 1075106001316 PspC domain; Region: PspC; pfam04024 1075106001317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1075106001318 PspC domain; Region: PspC; pfam04024 1075106001319 IncA protein; Region: IncA; pfam04156 1075106001320 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1075106001321 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1075106001322 homodimer interface [polypeptide binding]; other site 1075106001323 substrate-cofactor binding pocket; other site 1075106001324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001325 catalytic residue [active] 1075106001326 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1075106001327 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1075106001328 dimer interface [polypeptide binding]; other site 1075106001329 putative anticodon binding site; other site 1075106001330 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1075106001331 motif 1; other site 1075106001332 dimer interface [polypeptide binding]; other site 1075106001333 active site 1075106001334 motif 2; other site 1075106001335 motif 3; other site 1075106001336 Phospholipase B; Region: Phospholip_B; pfam04916 1075106001337 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1075106001338 trimer interface [polypeptide binding]; other site 1075106001339 active site 1075106001340 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1075106001341 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1075106001342 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1075106001343 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1075106001344 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1075106001345 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1075106001346 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1075106001347 UbiA prenyltransferase family; Region: UbiA; pfam01040 1075106001348 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106001349 catalytic core [active] 1075106001350 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106001351 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1075106001352 mannose-6-phosphate isomerase; Region: PLN02288 1075106001353 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1075106001354 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1075106001355 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1075106001356 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106001357 ATP binding site [chemical binding]; other site 1075106001358 Mg2+ binding site [ion binding]; other site 1075106001359 G-X-G motif; other site 1075106001360 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1075106001361 PhoU domain; Region: PhoU; pfam01895 1075106001362 PhoU domain; Region: PhoU; pfam01895 1075106001363 phosphoserine aminotransferase; Provisional; Region: PRK03080 1075106001364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1075106001365 catalytic residue [active] 1075106001366 CHAP domain; Region: CHAP; pfam05257 1075106001367 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1075106001368 NlpC/P60 family; Region: NLPC_P60; cl17555 1075106001369 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1075106001370 Ligand Binding Site [chemical binding]; other site 1075106001371 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1075106001372 Ligand Binding Site [chemical binding]; other site 1075106001373 OsmC-like protein; Region: OsmC; cl00767 1075106001374 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1075106001375 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1075106001376 dimerization interface [polypeptide binding]; other site 1075106001377 active site 1075106001378 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1075106001379 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1075106001380 folate binding site [chemical binding]; other site 1075106001381 NADP+ binding site [chemical binding]; other site 1075106001382 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1075106001383 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1075106001384 active site 1075106001385 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1075106001386 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106001387 NAD(P) binding site [chemical binding]; other site 1075106001388 active site 1075106001389 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1075106001390 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1075106001391 putative active site [active] 1075106001392 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1075106001393 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1075106001394 serine/threonine protein kinase; Provisional; Region: PRK14879 1075106001395 AAA domain; Region: AAA_21; pfam13304 1075106001396 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1075106001397 putative active site [active] 1075106001398 putative metal-binding site [ion binding]; other site 1075106001399 Cutinase; Region: Cutinase; pfam01083 1075106001400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1075106001401 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1075106001402 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1075106001403 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1075106001404 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1075106001405 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1075106001406 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1075106001407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1075106001408 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1075106001409 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1075106001410 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1075106001411 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1075106001412 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1075106001413 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1075106001414 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1075106001415 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1075106001416 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1075106001417 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1075106001418 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106001419 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106001420 DNA binding site [nucleotide binding] 1075106001421 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1075106001422 putative dimerization interface [polypeptide binding]; other site 1075106001423 putative ligand binding site [chemical binding]; other site 1075106001424 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1075106001425 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106001426 motif II; other site 1075106001427 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1075106001428 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1075106001429 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1075106001430 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1075106001431 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1075106001432 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1075106001433 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1075106001434 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1075106001435 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106001436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001437 dimer interface [polypeptide binding]; other site 1075106001438 conserved gate region; other site 1075106001439 putative PBP binding loops; other site 1075106001440 ABC-ATPase subunit interface; other site 1075106001441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001442 dimer interface [polypeptide binding]; other site 1075106001443 conserved gate region; other site 1075106001444 putative PBP binding loops; other site 1075106001445 ABC-ATPase subunit interface; other site 1075106001446 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106001447 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106001448 DNA binding site [nucleotide binding] 1075106001449 domain linker motif; other site 1075106001450 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1075106001451 ligand binding site [chemical binding]; other site 1075106001452 dimerization interface (open form) [polypeptide binding]; other site 1075106001453 dimerization interface (closed form) [polypeptide binding]; other site 1075106001454 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106001455 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1075106001456 active site 1075106001457 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1075106001458 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1075106001459 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106001460 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1075106001461 DXD motif; other site 1075106001462 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1075106001463 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1075106001464 Walker A/P-loop; other site 1075106001465 ATP binding site [chemical binding]; other site 1075106001466 Q-loop/lid; other site 1075106001467 ABC transporter signature motif; other site 1075106001468 Walker B; other site 1075106001469 D-loop; other site 1075106001470 H-loop/switch region; other site 1075106001471 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1075106001472 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1075106001473 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1075106001474 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1075106001475 Ligand Binding Site [chemical binding]; other site 1075106001476 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106001477 active site 1075106001478 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1075106001479 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106001480 Walker A motif; other site 1075106001481 ATP binding site [chemical binding]; other site 1075106001482 Walker B motif; other site 1075106001483 arginine finger; other site 1075106001484 Peptidase family M41; Region: Peptidase_M41; pfam01434 1075106001485 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1075106001486 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1075106001487 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1075106001488 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1075106001489 active site 1075106001490 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1075106001491 catalytic triad [active] 1075106001492 dimer interface [polypeptide binding]; other site 1075106001493 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1075106001494 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1075106001495 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1075106001496 ABC transporter; Region: ABC_tran_2; pfam12848 1075106001497 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1075106001498 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1075106001499 active site 1075106001500 catalytic residues [active] 1075106001501 metal binding site [ion binding]; metal-binding site 1075106001502 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1075106001503 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1075106001504 homodimer interface [polypeptide binding]; other site 1075106001505 substrate-cofactor binding pocket; other site 1075106001506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001507 catalytic residue [active] 1075106001508 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1075106001509 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1075106001510 xylose isomerase; Provisional; Region: PRK05474 1075106001511 xylose isomerase; Region: xylose_isom_A; TIGR02630 1075106001512 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1075106001513 active site 1075106001514 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106001515 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106001516 DNA binding site [nucleotide binding] 1075106001517 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 1075106001518 putative ligand binding site [chemical binding]; other site 1075106001519 putative dimerization interface [polypeptide binding]; other site 1075106001520 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1075106001521 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1075106001522 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1075106001523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001524 dimer interface [polypeptide binding]; other site 1075106001525 conserved gate region; other site 1075106001526 putative PBP binding loops; other site 1075106001527 ABC-ATPase subunit interface; other site 1075106001528 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106001529 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001530 dimer interface [polypeptide binding]; other site 1075106001531 conserved gate region; other site 1075106001532 putative PBP binding loops; other site 1075106001533 ABC-ATPase subunit interface; other site 1075106001534 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1075106001535 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1075106001536 inhibitor binding site; inhibition site 1075106001537 active site 1075106001538 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1075106001539 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1075106001540 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1075106001541 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1075106001542 substrate binding pocket [chemical binding]; other site 1075106001543 catalytic triad [active] 1075106001544 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1075106001545 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1075106001546 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1075106001547 active site 1075106001548 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1075106001549 D-xylulose kinase; Region: XylB; TIGR01312 1075106001550 nucleotide binding site [chemical binding]; other site 1075106001551 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1075106001552 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1075106001553 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1075106001554 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1075106001555 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1075106001556 PCRF domain; Region: PCRF; pfam03462 1075106001557 RF-1 domain; Region: RF-1; pfam00472 1075106001558 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1075106001559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1075106001560 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1075106001561 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1075106001562 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1075106001563 Mg++ binding site [ion binding]; other site 1075106001564 putative catalytic motif [active] 1075106001565 substrate binding site [chemical binding]; other site 1075106001566 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1075106001567 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1075106001568 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1075106001569 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1075106001570 active site 1075106001571 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1075106001572 catalytic site [active] 1075106001573 putative active site [active] 1075106001574 putative substrate binding site [chemical binding]; other site 1075106001575 dimer interface [polypeptide binding]; other site 1075106001576 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106001577 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1075106001578 active site 1075106001579 motif I; other site 1075106001580 motif II; other site 1075106001581 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1075106001582 AAA domain; Region: AAA_30; pfam13604 1075106001583 PIF1-like helicase; Region: PIF1; pfam05970 1075106001584 Protein of unknown function (DUF805); Region: DUF805; cl01224 1075106001585 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1075106001586 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1075106001587 dimer interface [polypeptide binding]; other site 1075106001588 motif 1; other site 1075106001589 active site 1075106001590 motif 2; other site 1075106001591 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1075106001592 putative deacylase active site [active] 1075106001593 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1075106001594 active site 1075106001595 motif 3; other site 1075106001596 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1075106001597 anticodon binding site; other site 1075106001598 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1075106001599 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1075106001600 dimer interface [polypeptide binding]; other site 1075106001601 ssDNA binding site [nucleotide binding]; other site 1075106001602 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106001603 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1075106001604 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1075106001605 active site 1075106001606 Zn binding site [ion binding]; other site 1075106001607 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1075106001608 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1075106001609 active site 1075106001610 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1075106001611 Citrate synthase; Region: Citrate_synt; pfam00285 1075106001612 oxalacetate binding site [chemical binding]; other site 1075106001613 citrylCoA binding site [chemical binding]; other site 1075106001614 coenzyme A binding site [chemical binding]; other site 1075106001615 catalytic triad [active] 1075106001616 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1075106001617 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1075106001618 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1075106001619 putative trimer interface [polypeptide binding]; other site 1075106001620 putative CoA binding site [chemical binding]; other site 1075106001621 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1075106001622 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1075106001623 RF-1 domain; Region: RF-1; pfam00472 1075106001624 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1075106001625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106001626 Walker A/P-loop; other site 1075106001627 ATP binding site [chemical binding]; other site 1075106001628 Q-loop/lid; other site 1075106001629 ABC transporter signature motif; other site 1075106001630 Walker B; other site 1075106001631 D-loop; other site 1075106001632 H-loop/switch region; other site 1075106001633 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1075106001634 FtsX-like permease family; Region: FtsX; pfam02687 1075106001635 Surface antigen [General function prediction only]; Region: COG3942 1075106001636 CHAP domain; Region: CHAP; pfam05257 1075106001637 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1075106001638 SmpB-tmRNA interface; other site 1075106001639 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106001640 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1075106001641 substrate binding pocket [chemical binding]; other site 1075106001642 membrane-bound complex binding site; other site 1075106001643 hinge residues; other site 1075106001644 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106001645 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1075106001646 substrate binding pocket [chemical binding]; other site 1075106001647 membrane-bound complex binding site; other site 1075106001648 hinge residues; other site 1075106001649 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1075106001650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001651 dimer interface [polypeptide binding]; other site 1075106001652 conserved gate region; other site 1075106001653 putative PBP binding loops; other site 1075106001654 ABC-ATPase subunit interface; other site 1075106001655 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1075106001656 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1075106001657 Walker A/P-loop; other site 1075106001658 ATP binding site [chemical binding]; other site 1075106001659 Q-loop/lid; other site 1075106001660 ABC transporter signature motif; other site 1075106001661 Walker B; other site 1075106001662 D-loop; other site 1075106001663 H-loop/switch region; other site 1075106001664 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1075106001665 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106001666 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106001667 active site 1075106001668 phosphorylation site [posttranslational modification] 1075106001669 intermolecular recognition site; other site 1075106001670 dimerization interface [polypeptide binding]; other site 1075106001671 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106001672 DNA binding residues [nucleotide binding] 1075106001673 dimerization interface [polypeptide binding]; other site 1075106001674 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1075106001675 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1075106001676 glutaminase active site [active] 1075106001677 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1075106001678 dimer interface [polypeptide binding]; other site 1075106001679 active site 1075106001680 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1075106001681 dimer interface [polypeptide binding]; other site 1075106001682 active site 1075106001683 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1075106001684 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1075106001685 active site 1075106001686 pantothenate kinase; Reviewed; Region: PRK13318 1075106001687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1075106001688 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1075106001689 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1075106001690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001691 dimer interface [polypeptide binding]; other site 1075106001692 conserved gate region; other site 1075106001693 putative PBP binding loops; other site 1075106001694 ABC-ATPase subunit interface; other site 1075106001695 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1075106001696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106001697 dimer interface [polypeptide binding]; other site 1075106001698 conserved gate region; other site 1075106001699 putative PBP binding loops; other site 1075106001700 ABC-ATPase subunit interface; other site 1075106001701 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1075106001702 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1075106001703 Walker A/P-loop; other site 1075106001704 ATP binding site [chemical binding]; other site 1075106001705 Q-loop/lid; other site 1075106001706 ABC transporter signature motif; other site 1075106001707 Walker B; other site 1075106001708 D-loop; other site 1075106001709 H-loop/switch region; other site 1075106001710 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1075106001711 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1075106001712 Walker A/P-loop; other site 1075106001713 ATP binding site [chemical binding]; other site 1075106001714 Q-loop/lid; other site 1075106001715 ABC transporter signature motif; other site 1075106001716 Walker B; other site 1075106001717 D-loop; other site 1075106001718 H-loop/switch region; other site 1075106001719 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1075106001720 cystathionine gamma-synthase; Provisional; Region: PRK07811 1075106001721 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1075106001722 homodimer interface [polypeptide binding]; other site 1075106001723 substrate-cofactor binding pocket; other site 1075106001724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001725 catalytic residue [active] 1075106001726 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1075106001727 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1075106001728 dimer interface [polypeptide binding]; other site 1075106001729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106001730 catalytic residue [active] 1075106001731 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1075106001732 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1075106001733 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106001734 ATP binding site [chemical binding]; other site 1075106001735 ATP binding site [chemical binding]; other site 1075106001736 putative Mg++ binding site [ion binding]; other site 1075106001737 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106001738 nucleotide binding region [chemical binding]; other site 1075106001739 ATP-binding site [chemical binding]; other site 1075106001740 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1075106001741 HRDC domain; Region: HRDC; pfam00570 1075106001742 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1075106001743 putative active site [active] 1075106001744 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1075106001745 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1075106001746 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1075106001747 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1075106001748 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1075106001749 active site 1075106001750 8-oxo-dGMP binding site [chemical binding]; other site 1075106001751 nudix motif; other site 1075106001752 metal binding site [ion binding]; metal-binding site 1075106001753 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1075106001754 PLD-like domain; Region: PLDc_2; pfam13091 1075106001755 putative homodimer interface [polypeptide binding]; other site 1075106001756 putative active site [active] 1075106001757 catalytic site [active] 1075106001758 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1075106001759 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106001760 ATP binding site [chemical binding]; other site 1075106001761 putative Mg++ binding site [ion binding]; other site 1075106001762 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106001763 nucleotide binding region [chemical binding]; other site 1075106001764 ATP-binding site [chemical binding]; other site 1075106001765 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1075106001766 Fic family protein [Function unknown]; Region: COG3177 1075106001767 Fic/DOC family; Region: Fic; cl00960 1075106001768 Protein of unknown function DUF262; Region: DUF262; pfam03235 1075106001769 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1075106001770 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1075106001771 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1075106001772 Fic/DOC family; Region: Fic; cl00960 1075106001773 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1075106001774 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106001775 Coenzyme A binding pocket [chemical binding]; other site 1075106001776 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1075106001777 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1075106001778 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1075106001779 putative active site [active] 1075106001780 metal binding site [ion binding]; metal-binding site 1075106001781 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1075106001782 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1075106001783 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1075106001784 alanine racemase; Reviewed; Region: alr; PRK00053 1075106001785 active site 1075106001786 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1075106001787 dimer interface [polypeptide binding]; other site 1075106001788 substrate binding site [chemical binding]; other site 1075106001789 catalytic residues [active] 1075106001790 DNA primase; Validated; Region: dnaG; PRK05667 1075106001791 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1075106001792 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1075106001793 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1075106001794 active site 1075106001795 metal binding site [ion binding]; metal-binding site 1075106001796 interdomain interaction site; other site 1075106001797 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1075106001798 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1075106001799 transmembrane helices; other site 1075106001800 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1075106001801 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1075106001802 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1075106001803 TPP-binding site; other site 1075106001804 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1075106001805 PYR/PP interface [polypeptide binding]; other site 1075106001806 dimer interface [polypeptide binding]; other site 1075106001807 TPP binding site [chemical binding]; other site 1075106001808 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1075106001809 AIR carboxylase; Region: AIRC; pfam00731 1075106001810 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1075106001811 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1075106001812 NAD binding site [chemical binding]; other site 1075106001813 ATP-grasp domain; Region: ATP-grasp; pfam02222 1075106001814 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1075106001815 metal binding site 2 [ion binding]; metal-binding site 1075106001816 putative DNA binding helix; other site 1075106001817 metal binding site 1 [ion binding]; metal-binding site 1075106001818 dimer interface [polypeptide binding]; other site 1075106001819 structural Zn2+ binding site [ion binding]; other site 1075106001820 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1075106001821 Putative esterase; Region: Esterase; pfam00756 1075106001822 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1075106001823 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1075106001824 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1075106001825 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1075106001826 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1075106001827 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1075106001828 dimerization interface [polypeptide binding]; other site 1075106001829 putative ATP binding site [chemical binding]; other site 1075106001830 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1075106001831 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1075106001832 active site 1075106001833 tetramer interface [polypeptide binding]; other site 1075106001834 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106001835 active site 1075106001836 Y-family of DNA polymerases; Region: PolY; cl12025 1075106001837 DNA polymerase IV; Reviewed; Region: PRK03103 1075106001838 active site 1075106001839 DNA binding site [nucleotide binding] 1075106001840 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1075106001841 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1075106001842 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1075106001843 Short C-terminal domain; Region: SHOCT; pfam09851 1075106001844 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1075106001845 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1075106001846 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1075106001847 dimerization interface [polypeptide binding]; other site 1075106001848 ATP binding site [chemical binding]; other site 1075106001849 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1075106001850 dimerization interface [polypeptide binding]; other site 1075106001851 ATP binding site [chemical binding]; other site 1075106001852 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1075106001853 conserved cys residue [active] 1075106001854 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1075106001855 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1075106001856 ATP binding site [chemical binding]; other site 1075106001857 active site 1075106001858 substrate binding site [chemical binding]; other site 1075106001859 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1075106001860 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106001861 ATP-grasp domain; Region: ATP-grasp; pfam02222 1075106001862 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1075106001863 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1075106001864 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1075106001865 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1075106001866 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1075106001867 catalytic residue [active] 1075106001868 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1075106001869 S17 interaction site [polypeptide binding]; other site 1075106001870 S8 interaction site; other site 1075106001871 16S rRNA interaction site [nucleotide binding]; other site 1075106001872 streptomycin interaction site [chemical binding]; other site 1075106001873 23S rRNA interaction site [nucleotide binding]; other site 1075106001874 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1075106001875 30S ribosomal protein S7; Validated; Region: PRK05302 1075106001876 elongation factor G; Reviewed; Region: PRK00007 1075106001877 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1075106001878 G1 box; other site 1075106001879 putative GEF interaction site [polypeptide binding]; other site 1075106001880 GTP/Mg2+ binding site [chemical binding]; other site 1075106001881 Switch I region; other site 1075106001882 G2 box; other site 1075106001883 G3 box; other site 1075106001884 Switch II region; other site 1075106001885 G4 box; other site 1075106001886 G5 box; other site 1075106001887 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1075106001888 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1075106001889 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1075106001890 elongation factor Tu; Reviewed; Region: PRK00049 1075106001891 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1075106001892 G1 box; other site 1075106001893 GEF interaction site [polypeptide binding]; other site 1075106001894 GTP/Mg2+ binding site [chemical binding]; other site 1075106001895 Switch I region; other site 1075106001896 G2 box; other site 1075106001897 G3 box; other site 1075106001898 Switch II region; other site 1075106001899 G4 box; other site 1075106001900 G5 box; other site 1075106001901 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1075106001902 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1075106001903 Antibiotic Binding Site [chemical binding]; other site 1075106001904 Plant phosphoribosyltransferase C-terminal; Region: PRT_C; pfam08372 1075106001905 elongation factor P; Validated; Region: PRK00529 1075106001906 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1075106001907 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1075106001908 RNA binding site [nucleotide binding]; other site 1075106001909 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1075106001910 RNA binding site [nucleotide binding]; other site 1075106001911 transcription antitermination factor NusB; Region: nusB; TIGR01951 1075106001912 putative RNA binding site [nucleotide binding]; other site 1075106001913 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1075106001914 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1075106001915 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1075106001916 catalytic site [active] 1075106001917 subunit interface [polypeptide binding]; other site 1075106001918 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1075106001919 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1075106001920 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1075106001921 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1075106001922 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1075106001923 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1075106001924 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1075106001925 IMP binding site; other site 1075106001926 dimer interface [polypeptide binding]; other site 1075106001927 interdomain contacts; other site 1075106001928 partial ornithine binding site; other site 1075106001929 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1075106001930 active site 1075106001931 dimer interface [polypeptide binding]; other site 1075106001932 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1075106001933 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1075106001934 catalytic site [active] 1075106001935 G-X2-G-X-G-K; other site 1075106001936 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1075106001937 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1075106001938 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1075106001939 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1075106001940 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1075106001941 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1075106001942 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1075106001943 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106001944 S-adenosylmethionine binding site [chemical binding]; other site 1075106001945 primosome assembly protein PriA; Provisional; Region: PRK14873 1075106001946 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1075106001947 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1075106001948 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1075106001949 putative active site [active] 1075106001950 substrate binding site [chemical binding]; other site 1075106001951 putative cosubstrate binding site; other site 1075106001952 catalytic site [active] 1075106001953 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1075106001954 substrate binding site [chemical binding]; other site 1075106001955 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1075106001956 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106001957 motif II; other site 1075106001958 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1075106001959 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1075106001960 proteasome ATPase; Region: pup_AAA; TIGR03689 1075106001961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106001962 Walker A motif; other site 1075106001963 ATP binding site [chemical binding]; other site 1075106001964 Walker B motif; other site 1075106001965 arginine finger; other site 1075106001966 Pup-ligase protein; Region: Pup_ligase; cl15463 1075106001967 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1075106001968 active site 1075106001969 Pup-like protein; Region: Pup; cl05289 1075106001970 Pup-ligase protein; Region: Pup_ligase; cl15463 1075106001971 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1075106001972 IHF dimer interface [polypeptide binding]; other site 1075106001973 IHF - DNA interface [nucleotide binding]; other site 1075106001974 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1075106001975 adenylosuccinate lyase; Provisional; Region: PRK09285 1075106001976 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1075106001977 tetramer interface [polypeptide binding]; other site 1075106001978 active site 1075106001979 Secretory lipase; Region: LIP; pfam03583 1075106001980 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1075106001981 metal ion-dependent adhesion site (MIDAS); other site 1075106001982 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1075106001983 metal ion-dependent adhesion site (MIDAS); other site 1075106001984 Protein of unknown function DUF58; Region: DUF58; pfam01882 1075106001985 MoxR-like ATPases [General function prediction only]; Region: COG0714 1075106001986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1075106001987 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1075106001988 ligand binding site [chemical binding]; other site 1075106001989 active site 1075106001990 UGI interface [polypeptide binding]; other site 1075106001991 catalytic site [active] 1075106001992 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1075106001993 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1075106001994 DNA-binding site [nucleotide binding]; DNA binding site 1075106001995 RNA-binding motif; other site 1075106001996 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1075106001997 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1075106001998 ring oligomerisation interface [polypeptide binding]; other site 1075106001999 ATP/Mg binding site [chemical binding]; other site 1075106002000 stacking interactions; other site 1075106002001 hinge regions; other site 1075106002002 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1075106002003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1075106002004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106002005 active site 1075106002006 phosphorylation site [posttranslational modification] 1075106002007 intermolecular recognition site; other site 1075106002008 dimerization interface [polypeptide binding]; other site 1075106002009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1075106002010 DNA binding site [nucleotide binding] 1075106002011 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1075106002012 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1075106002013 dimerization interface [polypeptide binding]; other site 1075106002014 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1075106002015 dimer interface [polypeptide binding]; other site 1075106002016 phosphorylation site [posttranslational modification] 1075106002017 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106002018 ATP binding site [chemical binding]; other site 1075106002019 Mg2+ binding site [ion binding]; other site 1075106002020 G-X-G motif; other site 1075106002021 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1075106002022 DNA-binding site [nucleotide binding]; DNA binding site 1075106002023 RNA-binding motif; other site 1075106002024 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1075106002025 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1075106002026 Ligand Binding Site [chemical binding]; other site 1075106002027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1075106002028 Ligand Binding Site [chemical binding]; other site 1075106002029 Clp protease ATP binding subunit; Region: clpC; CHL00095 1075106002030 Clp amino terminal domain; Region: Clp_N; pfam02861 1075106002031 Clp amino terminal domain; Region: Clp_N; pfam02861 1075106002032 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106002033 Walker A motif; other site 1075106002034 ATP binding site [chemical binding]; other site 1075106002035 Walker B motif; other site 1075106002036 arginine finger; other site 1075106002037 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106002038 Walker A motif; other site 1075106002039 ATP binding site [chemical binding]; other site 1075106002040 Walker B motif; other site 1075106002041 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1075106002042 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1075106002043 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1075106002044 dimer interface [polypeptide binding]; other site 1075106002045 anticodon binding site; other site 1075106002046 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1075106002047 motif 1; other site 1075106002048 dimer interface [polypeptide binding]; other site 1075106002049 active site 1075106002050 motif 2; other site 1075106002051 GAD domain; Region: GAD; pfam02938 1075106002052 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1075106002053 active site 1075106002054 motif 3; other site 1075106002055 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1075106002056 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1075106002057 dimer interface [polypeptide binding]; other site 1075106002058 motif 1; other site 1075106002059 active site 1075106002060 motif 2; other site 1075106002061 motif 3; other site 1075106002062 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1075106002063 anticodon binding site; other site 1075106002064 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1075106002065 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1075106002066 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1075106002067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1075106002068 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 1075106002069 catalytic site [active] 1075106002070 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1075106002071 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1075106002072 Walker A/P-loop; other site 1075106002073 ATP binding site [chemical binding]; other site 1075106002074 Q-loop/lid; other site 1075106002075 ABC transporter signature motif; other site 1075106002076 Walker B; other site 1075106002077 D-loop; other site 1075106002078 H-loop/switch region; other site 1075106002079 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106002080 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1075106002081 substrate binding pocket [chemical binding]; other site 1075106002082 membrane-bound complex binding site; other site 1075106002083 hinge residues; other site 1075106002084 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106002085 dimer interface [polypeptide binding]; other site 1075106002086 conserved gate region; other site 1075106002087 ABC-ATPase subunit interface; other site 1075106002088 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1075106002089 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106002090 dimer interface [polypeptide binding]; other site 1075106002091 conserved gate region; other site 1075106002092 putative PBP binding loops; other site 1075106002093 ABC-ATPase subunit interface; other site 1075106002094 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1075106002095 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1075106002096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106002097 ATP binding site [chemical binding]; other site 1075106002098 putative Mg++ binding site [ion binding]; other site 1075106002099 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106002100 nucleotide binding region [chemical binding]; other site 1075106002101 ATP-binding site [chemical binding]; other site 1075106002102 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1075106002103 recombination factor protein RarA; Reviewed; Region: PRK13342 1075106002104 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106002105 Walker A motif; other site 1075106002106 ATP binding site [chemical binding]; other site 1075106002107 Walker B motif; other site 1075106002108 arginine finger; other site 1075106002109 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1075106002110 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106002111 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106002112 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1075106002113 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1075106002114 acyl-activating enzyme (AAE) consensus motif; other site 1075106002115 putative AMP binding site [chemical binding]; other site 1075106002116 putative active site [active] 1075106002117 putative CoA binding site [chemical binding]; other site 1075106002118 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1075106002119 MULE transposase domain; Region: MULE; pfam10551 1075106002120 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106002121 Coenzyme A binding pocket [chemical binding]; other site 1075106002122 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1075106002123 hypothetical protein; Provisional; Region: PRK11770 1075106002124 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1075106002125 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1075106002126 Putative transcription activator [Transcription]; Region: TenA; COG0819 1075106002127 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1075106002128 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1075106002129 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1075106002130 active site 1075106002131 catalytic tetrad [active] 1075106002132 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106002133 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1075106002134 Walker A/P-loop; other site 1075106002135 ATP binding site [chemical binding]; other site 1075106002136 Q-loop/lid; other site 1075106002137 ABC transporter signature motif; other site 1075106002138 Walker B; other site 1075106002139 D-loop; other site 1075106002140 H-loop/switch region; other site 1075106002141 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106002142 Walker A/P-loop; other site 1075106002143 ATP binding site [chemical binding]; other site 1075106002144 Q-loop/lid; other site 1075106002145 ABC transporter signature motif; other site 1075106002146 Walker B; other site 1075106002147 D-loop; other site 1075106002148 H-loop/switch region; other site 1075106002149 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1075106002150 Predicted membrane protein [Function unknown]; Region: COG3601 1075106002151 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1075106002152 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1075106002153 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1075106002154 nucleotide binding site [chemical binding]; other site 1075106002155 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106002156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002157 homodimer interface [polypeptide binding]; other site 1075106002158 catalytic residue [active] 1075106002159 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1075106002160 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106002161 Walker A/P-loop; other site 1075106002162 ATP binding site [chemical binding]; other site 1075106002163 Q-loop/lid; other site 1075106002164 ABC transporter signature motif; other site 1075106002165 Walker B; other site 1075106002166 D-loop; other site 1075106002167 H-loop/switch region; other site 1075106002168 Ligase N family; Region: LIGANc; smart00532 1075106002169 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1075106002170 nucleotide binding pocket [chemical binding]; other site 1075106002171 K-X-D-G motif; other site 1075106002172 catalytic site [active] 1075106002173 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1075106002174 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1075106002175 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1075106002176 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1075106002177 Dimer interface [polypeptide binding]; other site 1075106002178 Domain of unknown function DUF59; Region: DUF59; cl00941 1075106002179 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1075106002180 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1075106002181 glutamine synthetase, type I; Region: GlnA; TIGR00653 1075106002182 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1075106002183 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1075106002184 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1075106002185 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1075106002186 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1075106002187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1075106002188 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1075106002189 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1075106002190 hypothetical protein; Provisional; Region: PRK07907 1075106002191 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1075106002192 active site 1075106002193 metal binding site [ion binding]; metal-binding site 1075106002194 dimer interface [polypeptide binding]; other site 1075106002195 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1075106002196 Histidine kinase; Region: HisKA_3; pfam07730 1075106002197 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1075106002198 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106002199 Q-loop/lid; other site 1075106002200 ABC transporter signature motif; other site 1075106002201 Walker B; other site 1075106002202 D-loop; other site 1075106002203 H-loop/switch region; other site 1075106002204 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1075106002205 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106002206 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1075106002207 Walker A/P-loop; other site 1075106002208 ATP binding site [chemical binding]; other site 1075106002209 Q-loop/lid; other site 1075106002210 ABC transporter signature motif; other site 1075106002211 Walker B; other site 1075106002212 D-loop; other site 1075106002213 H-loop/switch region; other site 1075106002214 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106002215 Walker A/P-loop; other site 1075106002216 ATP binding site [chemical binding]; other site 1075106002217 Q-loop/lid; other site 1075106002218 ABC transporter signature motif; other site 1075106002219 Walker B; other site 1075106002220 D-loop; other site 1075106002221 H-loop/switch region; other site 1075106002222 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1075106002223 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106002224 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1075106002225 Walker A/P-loop; other site 1075106002226 ATP binding site [chemical binding]; other site 1075106002227 Q-loop/lid; other site 1075106002228 ABC transporter signature motif; other site 1075106002229 Walker B; other site 1075106002230 D-loop; other site 1075106002231 H-loop/switch region; other site 1075106002232 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1075106002233 FtsX-like permease family; Region: FtsX; pfam02687 1075106002234 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1075106002235 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 1075106002236 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1075106002237 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1075106002238 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1075106002239 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1075106002240 dimer interface [polypeptide binding]; other site 1075106002241 motif 1; other site 1075106002242 active site 1075106002243 motif 2; other site 1075106002244 motif 3; other site 1075106002245 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1075106002246 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1075106002247 putative tRNA-binding site [nucleotide binding]; other site 1075106002248 B3/4 domain; Region: B3_4; pfam03483 1075106002249 tRNA synthetase B5 domain; Region: B5; smart00874 1075106002250 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1075106002251 dimer interface [polypeptide binding]; other site 1075106002252 motif 1; other site 1075106002253 motif 3; other site 1075106002254 motif 2; other site 1075106002255 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1075106002256 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1075106002257 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1075106002258 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1075106002259 heterotetramer interface [polypeptide binding]; other site 1075106002260 active site pocket [active] 1075106002261 cleavage site 1075106002262 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1075106002263 feedback inhibition sensing region; other site 1075106002264 homohexameric interface [polypeptide binding]; other site 1075106002265 nucleotide binding site [chemical binding]; other site 1075106002266 N-acetyl-L-glutamate binding site [chemical binding]; other site 1075106002267 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1075106002268 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1075106002269 inhibitor-cofactor binding pocket; inhibition site 1075106002270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002271 catalytic residue [active] 1075106002272 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1075106002273 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1075106002274 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1075106002275 arginine repressor; Provisional; Region: PRK03341 1075106002276 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1075106002277 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1075106002278 argininosuccinate synthase; Provisional; Region: PRK13820 1075106002279 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1075106002280 ANP binding site [chemical binding]; other site 1075106002281 Substrate Binding Site II [chemical binding]; other site 1075106002282 Substrate Binding Site I [chemical binding]; other site 1075106002283 argininosuccinate lyase; Provisional; Region: PRK00855 1075106002284 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1075106002285 active sites [active] 1075106002286 tetramer interface [polypeptide binding]; other site 1075106002287 acetoin reductases; Region: 23BDH; TIGR02415 1075106002288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106002289 NAD(P) binding site [chemical binding]; other site 1075106002290 active site 1075106002291 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1075106002292 Zn2+ binding site [ion binding]; other site 1075106002293 Mg2+ binding site [ion binding]; other site 1075106002294 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1075106002295 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1075106002296 active site 1075106002297 HIGH motif; other site 1075106002298 dimer interface [polypeptide binding]; other site 1075106002299 KMSKS motif; other site 1075106002300 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1075106002301 RNA binding surface [nucleotide binding]; other site 1075106002302 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1075106002303 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002304 active site 1075106002305 motif I; other site 1075106002306 motif II; other site 1075106002307 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002308 motif II; other site 1075106002309 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1075106002310 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1075106002311 RNA binding surface [nucleotide binding]; other site 1075106002312 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106002313 S-adenosylmethionine binding site [chemical binding]; other site 1075106002314 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1075106002315 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1075106002316 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1075106002317 TrkA-N domain; Region: TrkA_N; pfam02254 1075106002318 TrkA-C domain; Region: TrkA_C; pfam02080 1075106002319 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1075106002320 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1075106002321 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1075106002322 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1075106002323 Walker A/P-loop; other site 1075106002324 ATP binding site [chemical binding]; other site 1075106002325 Q-loop/lid; other site 1075106002326 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1075106002327 ABC transporter signature motif; other site 1075106002328 Walker B; other site 1075106002329 D-loop; other site 1075106002330 H-loop/switch region; other site 1075106002331 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1075106002332 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1075106002333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002334 motif II; other site 1075106002335 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1075106002336 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1075106002337 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002338 catalytic residue [active] 1075106002339 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1075106002340 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1075106002341 putative catalytic cysteine [active] 1075106002342 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1075106002343 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1075106002344 active site 1075106002345 (T/H)XGH motif; other site 1075106002346 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1075106002347 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1075106002348 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106002349 active site 1075106002350 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1075106002351 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1075106002352 Substrate binding site; other site 1075106002353 Mg++ binding site; other site 1075106002354 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1075106002355 active site 1075106002356 substrate binding site [chemical binding]; other site 1075106002357 CoA binding site [chemical binding]; other site 1075106002358 Oligomerisation domain; Region: Oligomerisation; pfam02410 1075106002359 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106002360 catalytic core [active] 1075106002361 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1075106002362 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106002363 catalytic core [active] 1075106002364 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1075106002365 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1075106002366 Cl binding site [ion binding]; other site 1075106002367 oligomer interface [polypeptide binding]; other site 1075106002368 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106002369 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1075106002370 substrate binding pocket [chemical binding]; other site 1075106002371 membrane-bound complex binding site; other site 1075106002372 hinge residues; other site 1075106002373 aminoacyl-tRNA ligase; Region: PLN02563 1075106002374 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106002375 active site 1075106002376 HIGH motif; other site 1075106002377 nucleotide binding site [chemical binding]; other site 1075106002378 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106002379 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1075106002380 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106002381 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106002382 active site 1075106002383 KMSKS motif; other site 1075106002384 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1075106002385 tRNA binding surface [nucleotide binding]; other site 1075106002386 Helix-hairpin-helix motif; Region: HHH; pfam00633 1075106002387 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1075106002388 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1075106002389 Competence protein; Region: Competence; pfam03772 1075106002390 hypothetical protein; Reviewed; Region: PRK07914 1075106002391 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1075106002392 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1075106002393 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1075106002394 Glycoprotease family; Region: Peptidase_M22; pfam00814 1075106002395 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1075106002396 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106002397 Coenzyme A binding pocket [chemical binding]; other site 1075106002398 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1075106002399 UGMP family protein; Validated; Region: PRK09604 1075106002400 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1075106002401 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; cl17043 1075106002402 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1075106002403 isocitrate dehydrogenase; Validated; Region: PRK08299 1075106002404 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1075106002405 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1075106002406 phosphate binding site [ion binding]; other site 1075106002407 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1075106002408 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1075106002409 acyl-activating enzyme (AAE) consensus motif; other site 1075106002410 putative AMP binding site [chemical binding]; other site 1075106002411 putative active site [active] 1075106002412 putative CoA binding site [chemical binding]; other site 1075106002413 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1075106002414 active site 1075106002415 catalytic residues [active] 1075106002416 metal binding site [ion binding]; metal-binding site 1075106002417 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1075106002418 rRNA interaction site [nucleotide binding]; other site 1075106002419 S8 interaction site; other site 1075106002420 putative laminin-1 binding site; other site 1075106002421 elongation factor Ts; Provisional; Region: tsf; PRK09377 1075106002422 UBA/TS-N domain; Region: UBA; pfam00627 1075106002423 Elongation factor TS; Region: EF_TS; pfam00889 1075106002424 Elongation factor TS; Region: EF_TS; pfam00889 1075106002425 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1075106002426 putative nucleotide binding site [chemical binding]; other site 1075106002427 uridine monophosphate binding site [chemical binding]; other site 1075106002428 homohexameric interface [polypeptide binding]; other site 1075106002429 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1075106002430 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1075106002431 hinge region; other site 1075106002432 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1075106002433 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1075106002434 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1075106002435 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1075106002436 FeS/SAM binding site; other site 1075106002437 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106002438 WHG domain; Region: WHG; pfam13305 1075106002439 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1075106002440 Walker A/P-loop; other site 1075106002441 ATP binding site [chemical binding]; other site 1075106002442 ABC transporter; Region: ABC_tran; pfam00005 1075106002443 Q-loop/lid; other site 1075106002444 ABC transporter signature motif; other site 1075106002445 Walker B; other site 1075106002446 D-loop; other site 1075106002447 H-loop/switch region; other site 1075106002448 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1075106002449 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1075106002450 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1075106002451 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1075106002452 substrate binding site [chemical binding]; other site 1075106002453 glutamase interaction surface [polypeptide binding]; other site 1075106002454 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1075106002455 anthranilate synthase component I; Provisional; Region: PRK13571 1075106002456 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1075106002457 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1075106002458 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1075106002459 putative uracil binding site [chemical binding]; other site 1075106002460 putative active site [active] 1075106002461 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 1075106002462 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1075106002463 active site 1075106002464 ribulose/triose binding site [chemical binding]; other site 1075106002465 phosphate binding site [ion binding]; other site 1075106002466 substrate (anthranilate) binding pocket [chemical binding]; other site 1075106002467 product (indole) binding pocket [chemical binding]; other site 1075106002468 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1075106002469 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002470 catalytic residue [active] 1075106002471 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1075106002472 substrate binding site [chemical binding]; other site 1075106002473 active site 1075106002474 catalytic residues [active] 1075106002475 heterodimer interface [polypeptide binding]; other site 1075106002476 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1075106002477 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1075106002478 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1075106002479 substrate binding site [chemical binding]; other site 1075106002480 hexamer interface [polypeptide binding]; other site 1075106002481 metal binding site [ion binding]; metal-binding site 1075106002482 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1075106002483 homodimer interface [polypeptide binding]; other site 1075106002484 putative metal binding site [ion binding]; other site 1075106002485 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1075106002486 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1075106002487 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1075106002488 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1075106002489 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1075106002490 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1075106002491 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1075106002492 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1075106002493 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106002494 phosphopeptide binding site; other site 1075106002495 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1075106002496 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1075106002497 DNA binding residues [nucleotide binding] 1075106002498 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1075106002499 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1075106002500 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1075106002501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002502 motif II; other site 1075106002503 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1075106002504 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1075106002505 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106002506 ATP binding site [chemical binding]; other site 1075106002507 putative Mg++ binding site [ion binding]; other site 1075106002508 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106002509 nucleotide binding region [chemical binding]; other site 1075106002510 ATP-binding site [chemical binding]; other site 1075106002511 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1075106002512 Predicted transcriptional regulator [Transcription]; Region: COG2378 1075106002513 WYL domain; Region: WYL; pfam13280 1075106002514 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106002515 active site 1075106002516 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 1075106002517 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1075106002518 active site 1075106002519 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1075106002520 CMP-binding site; other site 1075106002521 The sites determining sugar specificity; other site 1075106002522 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1075106002523 G1 box; other site 1075106002524 GTP/Mg2+ binding site [chemical binding]; other site 1075106002525 Switch I region; other site 1075106002526 G2 box; other site 1075106002527 Switch II region; other site 1075106002528 G3 box; other site 1075106002529 G4 box; other site 1075106002530 G5 box; other site 1075106002531 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1075106002532 G1 box; other site 1075106002533 GTP/Mg2+ binding site [chemical binding]; other site 1075106002534 Switch I region; other site 1075106002535 G2 box; other site 1075106002536 G3 box; other site 1075106002537 Switch II region; other site 1075106002538 G4 box; other site 1075106002539 G5 box; other site 1075106002540 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1075106002541 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1075106002542 RNA binding surface [nucleotide binding]; other site 1075106002543 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1075106002544 active site 1075106002545 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1075106002546 amphipathic channel; other site 1075106002547 Asn-Pro-Ala signature motifs; other site 1075106002548 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1075106002549 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1075106002550 purine monophosphate binding site [chemical binding]; other site 1075106002551 dimer interface [polypeptide binding]; other site 1075106002552 putative catalytic residues [active] 1075106002553 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1075106002554 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1075106002555 CoA binding domain; Region: CoA_binding; pfam02629 1075106002556 CoA-ligase; Region: Ligase_CoA; pfam00549 1075106002557 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1075106002558 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1075106002559 CoA-ligase; Region: Ligase_CoA; pfam00549 1075106002560 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106002561 active site 1075106002562 Preprotein translocase subunit; Region: YajC; pfam02699 1075106002563 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1075106002564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106002565 Walker A motif; other site 1075106002566 ATP binding site [chemical binding]; other site 1075106002567 Walker B motif; other site 1075106002568 arginine finger; other site 1075106002569 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1075106002570 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1075106002571 RuvA N terminal domain; Region: RuvA_N; pfam01330 1075106002572 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1075106002573 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1075106002574 active site 1075106002575 putative DNA-binding cleft [nucleotide binding]; other site 1075106002576 dimer interface [polypeptide binding]; other site 1075106002577 hypothetical protein; Validated; Region: PRK00110 1075106002578 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1075106002579 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1075106002580 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK07920 1075106002581 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1075106002582 putative acyl-acceptor binding pocket; other site 1075106002583 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1075106002584 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1075106002585 thiS-thiF/thiG interaction site; other site 1075106002586 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1075106002587 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1075106002588 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1075106002589 active site 1075106002590 dimer interface [polypeptide binding]; other site 1075106002591 motif 1; other site 1075106002592 motif 2; other site 1075106002593 motif 3; other site 1075106002594 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1075106002595 anticodon binding site; other site 1075106002596 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1075106002597 ABC transporter; Region: ABC_tran; pfam00005 1075106002598 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1075106002599 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106002600 Coenzyme A binding pocket [chemical binding]; other site 1075106002601 PAC2 family; Region: PAC2; pfam09754 1075106002602 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1075106002603 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1075106002604 chaperone protein DnaJ; Provisional; Region: PRK14278 1075106002605 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1075106002606 HSP70 interaction site [polypeptide binding]; other site 1075106002607 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1075106002608 Zn binding sites [ion binding]; other site 1075106002609 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1075106002610 dimer interface [polypeptide binding]; other site 1075106002611 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1075106002612 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1075106002613 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1075106002614 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1075106002615 TPP-binding site [chemical binding]; other site 1075106002616 dimer interface [polypeptide binding]; other site 1075106002617 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1075106002618 PYR/PP interface [polypeptide binding]; other site 1075106002619 dimer interface [polypeptide binding]; other site 1075106002620 TPP binding site [chemical binding]; other site 1075106002621 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1075106002622 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1075106002623 putative active site [active] 1075106002624 transaldolase; Provisional; Region: PRK03903 1075106002625 catalytic residue [active] 1075106002626 hypothetical protein; Validated; Region: PRK07682 1075106002627 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106002628 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002629 homodimer interface [polypeptide binding]; other site 1075106002630 catalytic residue [active] 1075106002631 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1075106002632 AsnC family; Region: AsnC_trans_reg; pfam01037 1075106002633 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 1075106002634 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1075106002635 non-specific DNA binding site [nucleotide binding]; other site 1075106002636 salt bridge; other site 1075106002637 sequence-specific DNA binding site [nucleotide binding]; other site 1075106002638 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106002639 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002640 homodimer interface [polypeptide binding]; other site 1075106002641 catalytic residue [active] 1075106002642 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1075106002643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002644 active site 1075106002645 motif I; other site 1075106002646 motif II; other site 1075106002647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002648 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1075106002649 triosephosphate isomerase; Provisional; Region: PRK14567 1075106002650 substrate binding site [chemical binding]; other site 1075106002651 dimer interface [polypeptide binding]; other site 1075106002652 catalytic triad [active] 1075106002653 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1075106002654 Phosphoglycerate kinase; Region: PGK; pfam00162 1075106002655 substrate binding site [chemical binding]; other site 1075106002656 hinge regions; other site 1075106002657 ADP binding site [chemical binding]; other site 1075106002658 catalytic site [active] 1075106002659 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1075106002660 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1075106002661 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1075106002662 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1075106002663 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1075106002664 shikimate binding site; other site 1075106002665 NAD(P) binding site [chemical binding]; other site 1075106002666 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 1075106002667 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1075106002668 GIY-YIG motif/motif A; other site 1075106002669 active site 1075106002670 catalytic site [active] 1075106002671 putative DNA binding site [nucleotide binding]; other site 1075106002672 metal binding site [ion binding]; metal-binding site 1075106002673 UvrB/uvrC motif; Region: UVR; pfam02151 1075106002674 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1075106002675 Helix-hairpin-helix motif; Region: HHH; pfam00633 1075106002676 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1075106002677 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1075106002678 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1075106002679 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1075106002680 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1075106002681 putative active site [active] 1075106002682 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1075106002683 Predicted esterase [General function prediction only]; Region: COG0400 1075106002684 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1075106002685 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106002686 Walker A/P-loop; other site 1075106002687 ATP binding site [chemical binding]; other site 1075106002688 Q-loop/lid; other site 1075106002689 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1075106002690 ABC transporter signature motif; other site 1075106002691 Walker B; other site 1075106002692 D-loop; other site 1075106002693 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1075106002694 Cation efflux family; Region: Cation_efflux; pfam01545 1075106002695 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1075106002696 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1075106002697 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1075106002698 active site 1075106002699 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1075106002700 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1075106002701 putative substrate binding site [chemical binding]; other site 1075106002702 putative ATP binding site [chemical binding]; other site 1075106002703 peroxiredoxin; Region: AhpC; TIGR03137 1075106002704 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1075106002705 dimer interface [polypeptide binding]; other site 1075106002706 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1075106002707 catalytic triad [active] 1075106002708 peroxidatic and resolving cysteines [active] 1075106002709 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1075106002710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1075106002711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1075106002712 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1075106002713 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1075106002714 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1075106002715 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1075106002716 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1075106002717 dimerization interface [polypeptide binding]; other site 1075106002718 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1075106002719 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106002720 motif II; other site 1075106002721 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1075106002722 putative active site [active] 1075106002723 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1075106002724 Predicted transcriptional regulators [Transcription]; Region: COG1733 1075106002725 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1075106002726 putative acetyltransferase; Provisional; Region: PRK03624 1075106002727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106002728 Coenzyme A binding pocket [chemical binding]; other site 1075106002729 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106002730 active site 1075106002731 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1075106002732 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1075106002733 heterodimer interface [polypeptide binding]; other site 1075106002734 active site 1075106002735 FMN binding site [chemical binding]; other site 1075106002736 homodimer interface [polypeptide binding]; other site 1075106002737 substrate binding site [chemical binding]; other site 1075106002738 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1075106002739 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1075106002740 FAD binding pocket [chemical binding]; other site 1075106002741 FAD binding motif [chemical binding]; other site 1075106002742 phosphate binding motif [ion binding]; other site 1075106002743 beta-alpha-beta structure motif; other site 1075106002744 NAD binding pocket [chemical binding]; other site 1075106002745 Iron coordination center [ion binding]; other site 1075106002746 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1075106002747 active site 1075106002748 dimer interface [polypeptide binding]; other site 1075106002749 dihydroorotase; Validated; Region: pyrC; PRK09357 1075106002750 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1075106002751 active site 1075106002752 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1075106002753 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1075106002754 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1075106002755 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1075106002756 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1075106002757 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1075106002758 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1075106002759 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1075106002760 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1075106002761 metal binding triad; other site 1075106002762 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1075106002763 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1075106002764 metal binding triad; other site 1075106002765 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1075106002766 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1075106002767 FAD binding site [chemical binding]; other site 1075106002768 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1075106002769 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1075106002770 THF binding site; other site 1075106002771 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1075106002772 substrate binding site [chemical binding]; other site 1075106002773 THF binding site; other site 1075106002774 zinc-binding site [ion binding]; other site 1075106002775 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106002776 catalytic core [active] 1075106002777 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1075106002778 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106002779 S-adenosylmethionine binding site [chemical binding]; other site 1075106002780 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1075106002781 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106002782 Walker A/P-loop; other site 1075106002783 ATP binding site [chemical binding]; other site 1075106002784 Q-loop/lid; other site 1075106002785 ABC transporter signature motif; other site 1075106002786 Walker B; other site 1075106002787 D-loop; other site 1075106002788 H-loop/switch region; other site 1075106002789 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1075106002790 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1075106002791 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1075106002792 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1075106002793 catalytic triad [active] 1075106002794 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1075106002795 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1075106002796 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1075106002797 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1075106002798 active site 1075106002799 dimer interface [polypeptide binding]; other site 1075106002800 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1075106002801 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1075106002802 active site 1075106002803 FMN binding site [chemical binding]; other site 1075106002804 substrate binding site [chemical binding]; other site 1075106002805 3Fe-4S cluster binding site [ion binding]; other site 1075106002806 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1075106002807 domain interface; other site 1075106002808 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1075106002809 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1075106002810 FeS/SAM binding site; other site 1075106002811 HemN C-terminal domain; Region: HemN_C; pfam06969 1075106002812 GTP-binding protein LepA; Provisional; Region: PRK05433 1075106002813 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1075106002814 G1 box; other site 1075106002815 putative GEF interaction site [polypeptide binding]; other site 1075106002816 GTP/Mg2+ binding site [chemical binding]; other site 1075106002817 Switch I region; other site 1075106002818 G2 box; other site 1075106002819 G3 box; other site 1075106002820 Switch II region; other site 1075106002821 G4 box; other site 1075106002822 G5 box; other site 1075106002823 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1075106002824 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1075106002825 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1075106002826 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1075106002827 UPF0126 domain; Region: UPF0126; pfam03458 1075106002828 Predicted membrane protein [Function unknown]; Region: COG2860 1075106002829 UPF0126 domain; Region: UPF0126; pfam03458 1075106002830 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1075106002831 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1075106002832 homodimer interface [polypeptide binding]; other site 1075106002833 substrate-cofactor binding pocket; other site 1075106002834 catalytic residue [active] 1075106002835 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1075106002836 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1075106002837 5S rRNA interface [nucleotide binding]; other site 1075106002838 CTC domain interface [polypeptide binding]; other site 1075106002839 L16 interface [polypeptide binding]; other site 1075106002840 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1075106002841 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1075106002842 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1075106002843 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1075106002844 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1075106002845 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1075106002846 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1075106002847 ligand binding site [chemical binding]; other site 1075106002848 homodimer interface [polypeptide binding]; other site 1075106002849 NAD(P) binding site [chemical binding]; other site 1075106002850 trimer interface B [polypeptide binding]; other site 1075106002851 trimer interface A [polypeptide binding]; other site 1075106002852 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1075106002853 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1075106002854 acyl-activating enzyme (AAE) consensus motif; other site 1075106002855 putative AMP binding site [chemical binding]; other site 1075106002856 putative active site [active] 1075106002857 putative CoA binding site [chemical binding]; other site 1075106002858 GTPase Era; Reviewed; Region: era; PRK00089 1075106002859 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1075106002860 G1 box; other site 1075106002861 GTP/Mg2+ binding site [chemical binding]; other site 1075106002862 Switch I region; other site 1075106002863 G2 box; other site 1075106002864 Switch II region; other site 1075106002865 G3 box; other site 1075106002866 G4 box; other site 1075106002867 G5 box; other site 1075106002868 KH domain; Region: KH_2; pfam07650 1075106002869 Domain of unknown function DUF21; Region: DUF21; pfam01595 1075106002870 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1075106002871 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1075106002872 Transporter associated domain; Region: CorC_HlyC; smart01091 1075106002873 metal-binding heat shock protein; Provisional; Region: PRK00016 1075106002874 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1075106002875 PhoH-like protein; Region: PhoH; pfam02562 1075106002876 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1075106002877 nucleotide binding site/active site [active] 1075106002878 HIT family signature motif; other site 1075106002879 catalytic residue [active] 1075106002880 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1075106002881 RNA methyltransferase, RsmE family; Region: TIGR00046 1075106002882 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1075106002883 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1075106002884 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1075106002885 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1075106002886 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1075106002887 ligand binding site; other site 1075106002888 oligomer interface; other site 1075106002889 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1075106002890 dimer interface [polypeptide binding]; other site 1075106002891 N-terminal domain interface [polypeptide binding]; other site 1075106002892 sulfate 1 binding site; other site 1075106002893 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1075106002894 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1075106002895 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1075106002896 trimerization site [polypeptide binding]; other site 1075106002897 active site 1075106002898 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1075106002899 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1075106002900 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1075106002901 catalytic residue [active] 1075106002902 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1075106002903 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1075106002904 Walker A/P-loop; other site 1075106002905 ATP binding site [chemical binding]; other site 1075106002906 Q-loop/lid; other site 1075106002907 ABC transporter signature motif; other site 1075106002908 Walker B; other site 1075106002909 D-loop; other site 1075106002910 H-loop/switch region; other site 1075106002911 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1075106002912 FeS assembly protein SufD; Region: sufD; TIGR01981 1075106002913 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1075106002914 FeS assembly protein SufB; Region: sufB; TIGR01980 1075106002915 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1075106002916 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1075106002917 CTP synthetase; Validated; Region: pyrG; PRK05380 1075106002918 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1075106002919 Catalytic site [active] 1075106002920 active site 1075106002921 UTP binding site [chemical binding]; other site 1075106002922 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1075106002923 active site 1075106002924 putative oxyanion hole; other site 1075106002925 catalytic triad [active] 1075106002926 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1075106002927 catalytic nucleophile [active] 1075106002928 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 1075106002929 GIY-YIG motif/motif A; other site 1075106002930 putative active site [active] 1075106002931 putative metal binding site [ion binding]; other site 1075106002932 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1075106002933 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1075106002934 trimer interface [polypeptide binding]; other site 1075106002935 active site 1075106002936 dimer interface [polypeptide binding]; other site 1075106002937 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 1075106002938 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1075106002939 ADP binding site [chemical binding]; other site 1075106002940 magnesium binding site [ion binding]; other site 1075106002941 putative shikimate binding site; other site 1075106002942 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1075106002943 active site 1075106002944 dimer interface [polypeptide binding]; other site 1075106002945 metal binding site [ion binding]; metal-binding site 1075106002946 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1075106002947 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1075106002948 Tetramer interface [polypeptide binding]; other site 1075106002949 active site 1075106002950 FMN-binding site [chemical binding]; other site 1075106002951 YceG-like family; Region: YceG; pfam02618 1075106002952 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1075106002953 dimerization interface [polypeptide binding]; other site 1075106002954 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1075106002955 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1075106002956 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1075106002957 motif 1; other site 1075106002958 active site 1075106002959 motif 2; other site 1075106002960 motif 3; other site 1075106002961 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1075106002962 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106002963 catalytic core [active] 1075106002964 Membrane protein of unknown function; Region: DUF360; pfam04020 1075106002965 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1075106002966 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1075106002967 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1075106002968 RNA binding surface [nucleotide binding]; other site 1075106002969 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1075106002970 Part of AAA domain; Region: AAA_19; pfam13245 1075106002971 Family description; Region: UvrD_C_2; pfam13538 1075106002972 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106002973 active site 1075106002974 xanthine permease; Region: pbuX; TIGR03173 1075106002975 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 1075106002976 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106002977 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106002978 homodimer interface [polypeptide binding]; other site 1075106002979 catalytic residue [active] 1075106002980 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1075106002981 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1075106002982 active site 1075106002983 Na/Ca binding site [ion binding]; other site 1075106002984 catalytic site [active] 1075106002985 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1075106002986 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1075106002987 catalytic triad [active] 1075106002988 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1075106002989 putative deacylase active site [active] 1075106002990 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1075106002991 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1075106002992 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1075106002993 Walker A/P-loop; other site 1075106002994 ATP binding site [chemical binding]; other site 1075106002995 Q-loop/lid; other site 1075106002996 ABC transporter signature motif; other site 1075106002997 Walker B; other site 1075106002998 D-loop; other site 1075106002999 H-loop/switch region; other site 1075106003000 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1075106003001 DNA-binding site [nucleotide binding]; DNA binding site 1075106003002 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1075106003003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1075106003004 non-specific DNA binding site [nucleotide binding]; other site 1075106003005 salt bridge; other site 1075106003006 sequence-specific DNA binding site [nucleotide binding]; other site 1075106003007 adenosine deaminase; Provisional; Region: PRK09358 1075106003008 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1075106003009 active site 1075106003010 Chorismate mutase type II; Region: CM_2; cl00693 1075106003011 hypothetical protein; Provisional; Region: PRK06761 1075106003012 hypothetical protein; Provisional; Region: PRK06761 1075106003013 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106003014 Coenzyme A binding pocket [chemical binding]; other site 1075106003015 AAA domain; Region: AAA_17; pfam13207 1075106003016 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1075106003017 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1075106003018 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1075106003019 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1075106003020 G1 box; other site 1075106003021 putative GEF interaction site [polypeptide binding]; other site 1075106003022 GTP/Mg2+ binding site [chemical binding]; other site 1075106003023 Switch I region; other site 1075106003024 G2 box; other site 1075106003025 G3 box; other site 1075106003026 Switch II region; other site 1075106003027 G4 box; other site 1075106003028 G5 box; other site 1075106003029 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1075106003030 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1075106003031 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1075106003032 Transposase domain (DUF772); Region: DUF772; pfam05598 1075106003033 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1075106003034 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1075106003035 GMP synthase; Reviewed; Region: guaA; PRK00074 1075106003036 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1075106003037 AMP/PPi binding site [chemical binding]; other site 1075106003038 candidate oxyanion hole; other site 1075106003039 catalytic triad [active] 1075106003040 potential glutamine specificity residues [chemical binding]; other site 1075106003041 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1075106003042 ATP Binding subdomain [chemical binding]; other site 1075106003043 Ligand Binding sites [chemical binding]; other site 1075106003044 Dimerization subdomain; other site 1075106003045 putative phosphoketolase; Provisional; Region: PRK05261 1075106003046 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1075106003047 TPP-binding site; other site 1075106003048 XFP C-terminal domain; Region: XFP_C; pfam09363 1075106003049 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1075106003050 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1075106003051 propionate/acetate kinase; Provisional; Region: PRK12379 1075106003052 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1075106003053 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1075106003054 hinge; other site 1075106003055 active site 1075106003056 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1075106003057 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1075106003058 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1075106003059 active site 1075106003060 catalytic site [active] 1075106003061 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1075106003062 dimer interface [polypeptide binding]; other site 1075106003063 ADP-ribose binding site [chemical binding]; other site 1075106003064 active site 1075106003065 nudix motif; other site 1075106003066 metal binding site [ion binding]; metal-binding site 1075106003067 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1075106003068 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1075106003069 DNA polymerase I; Provisional; Region: PRK05755 1075106003070 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1075106003071 active site 1075106003072 metal binding site 1 [ion binding]; metal-binding site 1075106003073 putative 5' ssDNA interaction site; other site 1075106003074 metal binding site 3; metal-binding site 1075106003075 metal binding site 2 [ion binding]; metal-binding site 1075106003076 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1075106003077 putative DNA binding site [nucleotide binding]; other site 1075106003078 putative metal binding site [ion binding]; other site 1075106003079 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1075106003080 active site 1075106003081 substrate binding site [chemical binding]; other site 1075106003082 catalytic site [active] 1075106003083 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1075106003084 active site 1075106003085 DNA binding site [nucleotide binding] 1075106003086 catalytic site [active] 1075106003087 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1075106003088 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003089 active site 1075106003090 phosphorylation site [posttranslational modification] 1075106003091 intermolecular recognition site; other site 1075106003092 dimerization interface [polypeptide binding]; other site 1075106003093 ANTAR domain; Region: ANTAR; pfam03861 1075106003094 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1075106003095 dimer interface [polypeptide binding]; other site 1075106003096 ADP-ribose binding site [chemical binding]; other site 1075106003097 active site 1075106003098 nudix motif; other site 1075106003099 metal binding site [ion binding]; metal-binding site 1075106003100 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1075106003101 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1075106003102 domain interfaces; other site 1075106003103 active site 1075106003104 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1075106003105 excinuclease ABC subunit B; Provisional; Region: PRK05298 1075106003106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106003107 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003108 nucleotide binding region [chemical binding]; other site 1075106003109 ATP-binding site [chemical binding]; other site 1075106003110 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1075106003111 UvrB/uvrC motif; Region: UVR; pfam02151 1075106003112 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1075106003113 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1075106003114 CoA-binding site [chemical binding]; other site 1075106003115 ATP-binding [chemical binding]; other site 1075106003116 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1075106003117 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1075106003118 RNA binding site [nucleotide binding]; other site 1075106003119 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1075106003120 RNA binding site [nucleotide binding]; other site 1075106003121 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1075106003122 RNA binding site [nucleotide binding]; other site 1075106003123 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1075106003124 RNA binding site [nucleotide binding]; other site 1075106003125 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1075106003126 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1075106003127 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1075106003128 homodimer interface [polypeptide binding]; other site 1075106003129 NADP binding site [chemical binding]; other site 1075106003130 substrate binding site [chemical binding]; other site 1075106003131 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1075106003132 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1075106003133 intersubunit interface [polypeptide binding]; other site 1075106003134 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1075106003135 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1075106003136 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1075106003137 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1075106003138 ABC-ATPase subunit interface; other site 1075106003139 dimer interface [polypeptide binding]; other site 1075106003140 putative PBP binding regions; other site 1075106003141 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1075106003142 homotrimer interaction site [polypeptide binding]; other site 1075106003143 zinc binding site [ion binding]; other site 1075106003144 CDP-binding sites; other site 1075106003145 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1075106003146 glycogen branching enzyme; Provisional; Region: PRK05402 1075106003147 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1075106003148 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1075106003149 active site 1075106003150 catalytic site [active] 1075106003151 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1075106003152 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1075106003153 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003154 active site 1075106003155 phosphorylation site [posttranslational modification] 1075106003156 intermolecular recognition site; other site 1075106003157 dimerization interface [polypeptide binding]; other site 1075106003158 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1075106003159 DNA binding site [nucleotide binding] 1075106003160 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1075106003161 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1075106003162 dimerization interface [polypeptide binding]; other site 1075106003163 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1075106003164 dimer interface [polypeptide binding]; other site 1075106003165 phosphorylation site [posttranslational modification] 1075106003166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106003167 ATP binding site [chemical binding]; other site 1075106003168 Mg2+ binding site [ion binding]; other site 1075106003169 G-X-G motif; other site 1075106003170 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1075106003171 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106003172 active site 1075106003173 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1075106003174 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1075106003175 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1075106003176 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1075106003177 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1075106003178 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1075106003179 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1075106003180 Transcription factor WhiB; Region: Whib; pfam02467 1075106003181 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1075106003182 PAS fold; Region: PAS_4; pfam08448 1075106003183 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1075106003184 Histidine kinase; Region: HisKA_2; pfam07568 1075106003185 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106003186 ATP binding site [chemical binding]; other site 1075106003187 Mg2+ binding site [ion binding]; other site 1075106003188 G-X-G motif; other site 1075106003189 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1075106003190 Haemolysin-III related; Region: HlyIII; pfam03006 1075106003191 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1075106003192 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1075106003193 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1075106003194 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1075106003195 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1075106003196 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1075106003197 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1075106003198 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1075106003199 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1075106003200 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1075106003201 Septum formation initiator; Region: DivIC; pfam04977 1075106003202 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1075106003203 enolase; Provisional; Region: eno; PRK00077 1075106003204 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1075106003205 dimer interface [polypeptide binding]; other site 1075106003206 metal binding site [ion binding]; metal-binding site 1075106003207 substrate binding pocket [chemical binding]; other site 1075106003208 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1075106003209 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003210 dimer interface [polypeptide binding]; other site 1075106003211 conserved gate region; other site 1075106003212 putative PBP binding loops; other site 1075106003213 ABC-ATPase subunit interface; other site 1075106003214 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1075106003215 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1075106003216 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1075106003217 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1075106003218 Walker A/P-loop; other site 1075106003219 ATP binding site [chemical binding]; other site 1075106003220 Q-loop/lid; other site 1075106003221 ABC transporter signature motif; other site 1075106003222 Walker B; other site 1075106003223 D-loop; other site 1075106003224 H-loop/switch region; other site 1075106003225 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1075106003226 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1075106003227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106003228 ATP binding site [chemical binding]; other site 1075106003229 putative Mg++ binding site [ion binding]; other site 1075106003230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003231 nucleotide binding region [chemical binding]; other site 1075106003232 ATP-binding site [chemical binding]; other site 1075106003233 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1075106003234 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1075106003235 putative active site [active] 1075106003236 catalytic residue [active] 1075106003237 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1075106003238 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1075106003239 Coenzyme A binding pocket [chemical binding]; other site 1075106003240 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1075106003241 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1075106003242 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1075106003243 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1075106003244 carbon starvation protein A; Provisional; Region: PRK15015 1075106003245 Carbon starvation protein CstA; Region: CstA; pfam02554 1075106003246 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1075106003247 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1075106003248 MarR family; Region: MarR_2; pfam12802 1075106003249 Ubinuclein conserved middle domain; Region: UBN_AB; pfam14075 1075106003250 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1075106003251 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1075106003252 Aspartase; Region: Aspartase; cd01357 1075106003253 active sites [active] 1075106003254 tetramer interface [polypeptide binding]; other site 1075106003255 FeoA domain; Region: FeoA; pfam04023 1075106003256 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1075106003257 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1075106003258 G1 box; other site 1075106003259 GTP/Mg2+ binding site [chemical binding]; other site 1075106003260 Switch I region; other site 1075106003261 G2 box; other site 1075106003262 G3 box; other site 1075106003263 Switch II region; other site 1075106003264 G4 box; other site 1075106003265 G5 box; other site 1075106003266 Nucleoside recognition; Region: Gate; pfam07670 1075106003267 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1075106003268 Nucleoside recognition; Region: Gate; pfam07670 1075106003269 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1075106003270 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1075106003271 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1075106003272 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1075106003273 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1075106003274 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1075106003275 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1075106003276 putative active site [active] 1075106003277 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1075106003278 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1075106003279 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1075106003280 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1075106003281 catalytic triad [active] 1075106003282 active site nucleophile [active] 1075106003283 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1075106003284 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1075106003285 SelR domain; Region: SelR; pfam01641 1075106003286 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1075106003287 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1075106003288 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1075106003289 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106003290 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1075106003291 Uncharacterized conserved protein [Function unknown]; Region: COG3350 1075106003292 classical (c) SDRs; Region: SDR_c; cd05233 1075106003293 NAD(P) binding site [chemical binding]; other site 1075106003294 active site 1075106003295 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1075106003296 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1075106003297 ATP binding site [chemical binding]; other site 1075106003298 Mg++ binding site [ion binding]; other site 1075106003299 motif III; other site 1075106003300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003301 nucleotide binding region [chemical binding]; other site 1075106003302 ATP-binding site [chemical binding]; other site 1075106003303 Predicted membrane protein [Function unknown]; Region: COG2855 1075106003304 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1075106003305 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1075106003306 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1075106003307 substrate binding pocket [chemical binding]; other site 1075106003308 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1075106003309 GTP-binding protein YchF; Reviewed; Region: PRK09601 1075106003310 YchF GTPase; Region: YchF; cd01900 1075106003311 G1 box; other site 1075106003312 GTP/Mg2+ binding site [chemical binding]; other site 1075106003313 Switch I region; other site 1075106003314 G2 box; other site 1075106003315 Switch II region; other site 1075106003316 G3 box; other site 1075106003317 G4 box; other site 1075106003318 G5 box; other site 1075106003319 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1075106003320 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1075106003321 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1075106003322 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1075106003323 Histidine kinase; Region: HisKA_3; pfam07730 1075106003324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106003325 ATP binding site [chemical binding]; other site 1075106003326 Mg2+ binding site [ion binding]; other site 1075106003327 G-X-G motif; other site 1075106003328 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106003329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003330 active site 1075106003331 phosphorylation site [posttranslational modification] 1075106003332 intermolecular recognition site; other site 1075106003333 dimerization interface [polypeptide binding]; other site 1075106003334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106003335 DNA binding residues [nucleotide binding] 1075106003336 dimerization interface [polypeptide binding]; other site 1075106003337 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106003338 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1075106003339 FtsX-like permease family; Region: FtsX; pfam02687 1075106003340 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106003341 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1075106003342 Walker A/P-loop; other site 1075106003343 ATP binding site [chemical binding]; other site 1075106003344 Q-loop/lid; other site 1075106003345 ABC transporter signature motif; other site 1075106003346 Walker B; other site 1075106003347 D-loop; other site 1075106003348 H-loop/switch region; other site 1075106003349 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1075106003350 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1075106003351 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106003352 Walker A/P-loop; other site 1075106003353 ATP binding site [chemical binding]; other site 1075106003354 Q-loop/lid; other site 1075106003355 ABC transporter signature motif; other site 1075106003356 Walker B; other site 1075106003357 D-loop; other site 1075106003358 H-loop/switch region; other site 1075106003359 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1075106003360 Walker A/P-loop; other site 1075106003361 ATP binding site [chemical binding]; other site 1075106003362 Q-loop/lid; other site 1075106003363 ABC transporter signature motif; other site 1075106003364 Walker B; other site 1075106003365 D-loop; other site 1075106003366 H-loop/switch region; other site 1075106003367 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1075106003368 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1075106003369 homodimer interface [polypeptide binding]; other site 1075106003370 substrate-cofactor binding pocket; other site 1075106003371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106003372 catalytic residue [active] 1075106003373 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1075106003374 dimer interface [polypeptide binding]; other site 1075106003375 pyridoxal binding site [chemical binding]; other site 1075106003376 ATP binding site [chemical binding]; other site 1075106003377 hypothetical protein; Provisional; Region: PRK14681 1075106003378 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1075106003379 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1075106003380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106003381 Walker A motif; other site 1075106003382 ATP binding site [chemical binding]; other site 1075106003383 Walker B motif; other site 1075106003384 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1075106003385 DNA protecting protein DprA; Region: dprA; TIGR00732 1075106003386 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1075106003387 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1075106003388 L-aspartate oxidase; Provisional; Region: PRK06175 1075106003389 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1075106003390 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1075106003391 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1075106003392 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1075106003393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106003394 S-adenosylmethionine binding site [chemical binding]; other site 1075106003395 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1075106003396 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1075106003397 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1075106003398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106003399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106003400 homodimer interface [polypeptide binding]; other site 1075106003401 catalytic residue [active] 1075106003402 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1075106003403 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1075106003404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106003405 Walker A motif; other site 1075106003406 ATP binding site [chemical binding]; other site 1075106003407 Walker B motif; other site 1075106003408 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1075106003409 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1075106003410 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1075106003411 oligomer interface [polypeptide binding]; other site 1075106003412 active site residues [active] 1075106003413 Clp protease; Region: CLP_protease; pfam00574 1075106003414 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1075106003415 oligomer interface [polypeptide binding]; other site 1075106003416 active site residues [active] 1075106003417 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1075106003418 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1075106003419 putative ion selectivity filter; other site 1075106003420 putative pore gating glutamate residue; other site 1075106003421 trigger factor; Provisional; Region: tig; PRK01490 1075106003422 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1075106003423 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1075106003424 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1075106003425 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1075106003426 active site 1075106003427 catalytic site [active] 1075106003428 substrate binding site [chemical binding]; other site 1075106003429 HRDC domain; Region: HRDC; pfam00570 1075106003430 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1075106003431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1075106003432 FeS/SAM binding site; other site 1075106003433 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1075106003434 Pyruvate formate lyase 1; Region: PFL1; cd01678 1075106003435 coenzyme A binding site [chemical binding]; other site 1075106003436 active site 1075106003437 catalytic residues [active] 1075106003438 glycine loop; other site 1075106003439 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1075106003440 NAD synthetase; Provisional; Region: PRK13981 1075106003441 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1075106003442 multimer interface [polypeptide binding]; other site 1075106003443 active site 1075106003444 catalytic triad [active] 1075106003445 protein interface 1 [polypeptide binding]; other site 1075106003446 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1075106003447 homodimer interface [polypeptide binding]; other site 1075106003448 NAD binding pocket [chemical binding]; other site 1075106003449 ATP binding pocket [chemical binding]; other site 1075106003450 Mg binding site [ion binding]; other site 1075106003451 active-site loop [active] 1075106003452 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1075106003453 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1075106003454 metal binding site [ion binding]; metal-binding site 1075106003455 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1075106003456 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1075106003457 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1075106003458 Walker A/P-loop; other site 1075106003459 ATP binding site [chemical binding]; other site 1075106003460 Q-loop/lid; other site 1075106003461 ABC transporter signature motif; other site 1075106003462 Walker B; other site 1075106003463 D-loop; other site 1075106003464 H-loop/switch region; other site 1075106003465 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1075106003466 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1075106003467 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1075106003468 active site 1075106003469 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1075106003470 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1075106003471 Zn2+ binding site [ion binding]; other site 1075106003472 Mg2+ binding site [ion binding]; other site 1075106003473 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1075106003474 synthetase active site [active] 1075106003475 NTP binding site [chemical binding]; other site 1075106003476 metal binding site [ion binding]; metal-binding site 1075106003477 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1075106003478 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1075106003479 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1075106003480 trimer interface [polypeptide binding]; other site 1075106003481 active site 1075106003482 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1075106003483 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1075106003484 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1075106003485 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1075106003486 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1075106003487 CAP-like domain; other site 1075106003488 active site 1075106003489 primary dimer interface [polypeptide binding]; other site 1075106003490 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1075106003491 EamA-like transporter family; Region: EamA; cl17759 1075106003492 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1075106003493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106003494 ATP binding site [chemical binding]; other site 1075106003495 putative Mg++ binding site [ion binding]; other site 1075106003496 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1075106003497 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003498 nucleotide binding region [chemical binding]; other site 1075106003499 ATP-binding site [chemical binding]; other site 1075106003500 DEAD/H associated; Region: DEAD_assoc; pfam08494 1075106003501 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106003502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106003503 putative substrate translocation pore; other site 1075106003504 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1075106003505 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1075106003506 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1075106003507 ATP binding site [chemical binding]; other site 1075106003508 Mg2+ binding site [ion binding]; other site 1075106003509 G-X-G motif; other site 1075106003510 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1075106003511 anchoring element; other site 1075106003512 dimer interface [polypeptide binding]; other site 1075106003513 ATP binding site [chemical binding]; other site 1075106003514 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1075106003515 active site 1075106003516 putative metal-binding site [ion binding]; other site 1075106003517 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1075106003518 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1075106003519 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1075106003520 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1075106003521 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1075106003522 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1075106003523 DNA binding residues [nucleotide binding] 1075106003524 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1075106003525 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1075106003526 substrate binding pocket [chemical binding]; other site 1075106003527 chain length determination region; other site 1075106003528 substrate-Mg2+ binding site; other site 1075106003529 catalytic residues [active] 1075106003530 aspartate-rich region 1; other site 1075106003531 active site lid residues [active] 1075106003532 aspartate-rich region 2; other site 1075106003533 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106003534 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1075106003535 active site 1075106003536 ATP binding site [chemical binding]; other site 1075106003537 substrate binding site [chemical binding]; other site 1075106003538 activation loop (A-loop); other site 1075106003539 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106003540 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106003541 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1075106003542 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1075106003543 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1075106003544 putative acyl-acceptor binding pocket; other site 1075106003545 TrbC/VIRB2 family; Region: TrbC; pfam04956 1075106003546 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1075106003547 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1075106003548 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1075106003549 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1075106003550 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1075106003551 ATP binding site [chemical binding]; other site 1075106003552 putative Mg++ binding site [ion binding]; other site 1075106003553 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1075106003554 SEC-C motif; Region: SEC-C; pfam02810 1075106003555 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1075106003556 30S subunit binding site; other site 1075106003557 RecX family; Region: RecX; pfam02631 1075106003558 recombinase A; Provisional; Region: recA; PRK09354 1075106003559 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1075106003560 hexamer interface [polypeptide binding]; other site 1075106003561 Walker A motif; other site 1075106003562 ATP binding site [chemical binding]; other site 1075106003563 Walker B motif; other site 1075106003564 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1075106003565 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1075106003566 non-specific DNA binding site [nucleotide binding]; other site 1075106003567 salt bridge; other site 1075106003568 sequence-specific DNA binding site [nucleotide binding]; other site 1075106003569 Competence-damaged protein; Region: CinA; pfam02464 1075106003570 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1075106003571 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1075106003572 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1075106003573 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1075106003574 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1075106003575 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1075106003576 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1075106003577 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1075106003578 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1075106003579 FeS/SAM binding site; other site 1075106003580 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1075106003581 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1075106003582 synthetase active site [active] 1075106003583 NTP binding site [chemical binding]; other site 1075106003584 metal binding site [ion binding]; metal-binding site 1075106003585 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1075106003586 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1075106003587 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1075106003588 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1075106003589 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1075106003590 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1075106003591 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1075106003592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106003593 Walker A/P-loop; other site 1075106003594 ATP binding site [chemical binding]; other site 1075106003595 Q-loop/lid; other site 1075106003596 ABC transporter signature motif; other site 1075106003597 Walker B; other site 1075106003598 D-loop; other site 1075106003599 H-loop/switch region; other site 1075106003600 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1075106003601 Histidine kinase; Region: HisKA_3; pfam07730 1075106003602 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106003603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003604 active site 1075106003605 phosphorylation site [posttranslational modification] 1075106003606 intermolecular recognition site; other site 1075106003607 dimerization interface [polypeptide binding]; other site 1075106003608 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106003609 DNA binding residues [nucleotide binding] 1075106003610 dimerization interface [polypeptide binding]; other site 1075106003611 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106003612 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106003613 Protein of unknown function DUF262; Region: DUF262; pfam03235 1075106003614 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1075106003615 Protein of unknown function DUF262; Region: DUF262; pfam03235 1075106003616 maltose O-acetyltransferase; Provisional; Region: PRK10092 1075106003617 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1075106003618 active site 1075106003619 substrate binding site [chemical binding]; other site 1075106003620 trimer interface [polypeptide binding]; other site 1075106003621 CoA binding site [chemical binding]; other site 1075106003622 aconitate hydratase; Validated; Region: PRK09277 1075106003623 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1075106003624 substrate binding site [chemical binding]; other site 1075106003625 ligand binding site [chemical binding]; other site 1075106003626 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1075106003627 substrate binding site [chemical binding]; other site 1075106003628 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1075106003629 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106003630 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1075106003631 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1075106003632 Protein of unknown function (DUF418); Region: DUF418; cl12135 1075106003633 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1075106003634 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1075106003635 TRAM domain; Region: TRAM; cl01282 1075106003636 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1075106003637 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1075106003638 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1075106003639 putative active site [active] 1075106003640 putative catalytic site [active] 1075106003641 putative DNA binding site [nucleotide binding]; other site 1075106003642 putative phosphate binding site [ion binding]; other site 1075106003643 metal binding site A [ion binding]; metal-binding site 1075106003644 putative AP binding site [nucleotide binding]; other site 1075106003645 putative metal binding site B [ion binding]; other site 1075106003646 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1075106003647 AAA domain; Region: AAA_21; pfam13304 1075106003648 Walker A/P-loop; other site 1075106003649 ATP binding site [chemical binding]; other site 1075106003650 Q-loop/lid; other site 1075106003651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1075106003652 ABC transporter signature motif; other site 1075106003653 Walker B; other site 1075106003654 D-loop; other site 1075106003655 H-loop/switch region; other site 1075106003656 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1075106003657 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1075106003658 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1075106003659 Walker A/P-loop; other site 1075106003660 ATP binding site [chemical binding]; other site 1075106003661 Q-loop/lid; other site 1075106003662 ABC transporter signature motif; other site 1075106003663 Walker B; other site 1075106003664 D-loop; other site 1075106003665 H-loop/switch region; other site 1075106003666 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1075106003667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003668 dimer interface [polypeptide binding]; other site 1075106003669 conserved gate region; other site 1075106003670 putative PBP binding loops; other site 1075106003671 ABC-ATPase subunit interface; other site 1075106003672 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1075106003673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003674 dimer interface [polypeptide binding]; other site 1075106003675 conserved gate region; other site 1075106003676 putative PBP binding loops; other site 1075106003677 ABC-ATPase subunit interface; other site 1075106003678 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1075106003679 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1075106003680 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1075106003681 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1075106003682 active site 1075106003683 DNA binding site [nucleotide binding] 1075106003684 Int/Topo IB signature motif; other site 1075106003685 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106003686 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1075106003687 Walker A/P-loop; other site 1075106003688 ATP binding site [chemical binding]; other site 1075106003689 Q-loop/lid; other site 1075106003690 ABC transporter signature motif; other site 1075106003691 Walker B; other site 1075106003692 D-loop; other site 1075106003693 H-loop/switch region; other site 1075106003694 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1075106003695 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106003696 FtsX-like permease family; Region: FtsX; pfam02687 1075106003697 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106003698 FtsX-like permease family; Region: FtsX; pfam02687 1075106003699 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1075106003700 prephenate dehydrogenase; Validated; Region: PRK08507 1075106003701 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1075106003702 Prephenate dehydratase; Region: PDT; pfam00800 1075106003703 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1075106003704 putative L-Phe binding site [chemical binding]; other site 1075106003705 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1075106003706 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1075106003707 G1 box; other site 1075106003708 putative GEF interaction site [polypeptide binding]; other site 1075106003709 GTP/Mg2+ binding site [chemical binding]; other site 1075106003710 Switch I region; other site 1075106003711 G2 box; other site 1075106003712 G3 box; other site 1075106003713 Switch II region; other site 1075106003714 G4 box; other site 1075106003715 G5 box; other site 1075106003716 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1075106003717 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1075106003718 benzoate transport; Region: 2A0115; TIGR00895 1075106003719 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106003720 putative substrate translocation pore; other site 1075106003721 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1075106003722 nudix motif; other site 1075106003723 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1075106003724 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1075106003725 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1075106003726 P-loop; other site 1075106003727 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1075106003728 Magnesium ion binding site [ion binding]; other site 1075106003729 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1075106003730 Magnesium ion binding site [ion binding]; other site 1075106003731 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1075106003732 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1075106003733 active site 1075106003734 Int/Topo IB signature motif; other site 1075106003735 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1075106003736 23S rRNA binding site [nucleotide binding]; other site 1075106003737 L21 binding site [polypeptide binding]; other site 1075106003738 L13 binding site [polypeptide binding]; other site 1075106003739 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1075106003740 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1075106003741 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1075106003742 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1075106003743 Thiamine pyrophosphokinase; Region: TPK; cd07995 1075106003744 active site 1075106003745 dimerization interface [polypeptide binding]; other site 1075106003746 thiamine binding site [chemical binding]; other site 1075106003747 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1075106003748 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1075106003749 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1075106003750 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1075106003751 putative deacylase active site [active] 1075106003752 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1075106003753 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1075106003754 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1075106003755 active site 1075106003756 catalytic residues [active] 1075106003757 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1075106003758 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1075106003759 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1075106003760 DNA binding residues [nucleotide binding] 1075106003761 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1075106003762 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1075106003763 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003764 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003765 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1075106003766 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1075106003767 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1075106003768 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003769 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003770 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1075106003771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1075106003772 active site 1075106003773 phosphorylation site [posttranslational modification] 1075106003774 intermolecular recognition site; other site 1075106003775 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1075106003776 DNA binding residues [nucleotide binding] 1075106003777 dimerization interface [polypeptide binding]; other site 1075106003778 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1075106003779 Histidine kinase; Region: HisKA_3; pfam07730 1075106003780 proline aminopeptidase P II; Provisional; Region: PRK10879 1075106003781 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1075106003782 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1075106003783 active site 1075106003784 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1075106003785 nudix motif; other site 1075106003786 MarR family; Region: MarR_2; cl17246 1075106003787 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1075106003788 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1075106003789 nucleotide binding site [chemical binding]; other site 1075106003790 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1075106003791 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1075106003792 putative substrate binding site [chemical binding]; other site 1075106003793 putative ATP binding site [chemical binding]; other site 1075106003794 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1075106003795 putative active site [active] 1075106003796 dimerization interface [polypeptide binding]; other site 1075106003797 putative tRNAtyr binding site [nucleotide binding]; other site 1075106003798 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1075106003799 active site 1075106003800 DNA binding site [nucleotide binding] 1075106003801 Int/Topo IB signature motif; other site 1075106003802 Helix-turn-helix domain; Region: HTH_17; pfam12728 1075106003803 Helix-turn-helix domain; Region: HTH_17; pfam12728 1075106003804 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1075106003805 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1075106003806 Walker A motif; other site 1075106003807 ATP binding site [chemical binding]; other site 1075106003808 Walker B motif; other site 1075106003809 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1075106003810 Phage capsid family; Region: Phage_capsid; pfam05065 1075106003811 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1075106003812 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1075106003813 Walker A/P-loop; other site 1075106003814 ATP binding site [chemical binding]; other site 1075106003815 Q-loop/lid; other site 1075106003816 ABC transporter signature motif; other site 1075106003817 Walker B; other site 1075106003818 D-loop; other site 1075106003819 H-loop/switch region; other site 1075106003820 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1075106003821 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1075106003822 Walker A/P-loop; other site 1075106003823 ATP binding site [chemical binding]; other site 1075106003824 Q-loop/lid; other site 1075106003825 ABC transporter signature motif; other site 1075106003826 Walker B; other site 1075106003827 D-loop; other site 1075106003828 H-loop/switch region; other site 1075106003829 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1075106003830 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1075106003831 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1075106003832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003833 dimer interface [polypeptide binding]; other site 1075106003834 conserved gate region; other site 1075106003835 ABC-ATPase subunit interface; other site 1075106003836 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1075106003837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106003838 dimer interface [polypeptide binding]; other site 1075106003839 conserved gate region; other site 1075106003840 putative PBP binding loops; other site 1075106003841 ABC-ATPase subunit interface; other site 1075106003842 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1075106003843 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1075106003844 cell division protein FtsQ; Provisional; Region: PRK05529 1075106003845 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1075106003846 Cell division protein FtsQ; Region: FtsQ; pfam03799 1075106003847 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1075106003848 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1075106003849 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003850 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003851 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1075106003852 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1075106003853 active site 1075106003854 homodimer interface [polypeptide binding]; other site 1075106003855 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1075106003856 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1075106003857 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1075106003858 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003859 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003860 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1075106003861 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1075106003862 Mg++ binding site [ion binding]; other site 1075106003863 putative catalytic motif [active] 1075106003864 putative substrate binding site [chemical binding]; other site 1075106003865 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1075106003866 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1075106003867 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1075106003868 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1075106003869 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 1075106003870 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1075106003871 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1075106003872 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1075106003873 MraW methylase family; Region: Methyltransf_5; cl17771 1075106003874 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1075106003875 MraZ protein; Region: MraZ; pfam02381 1075106003876 cell division protein MraZ; Reviewed; Region: PRK00326 1075106003877 MraZ protein; Region: MraZ; pfam02381 1075106003878 Part of AAA domain; Region: AAA_19; pfam13245 1075106003879 Family description; Region: UvrD_C_2; pfam13538 1075106003880 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1075106003881 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1075106003882 ligand binding site [chemical binding]; other site 1075106003883 NAD binding site [chemical binding]; other site 1075106003884 tetramer interface [polypeptide binding]; other site 1075106003885 catalytic site [active] 1075106003886 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1075106003887 L-serine binding site [chemical binding]; other site 1075106003888 ACT domain interface; other site 1075106003889 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1075106003890 ATP cone domain; Region: ATP-cone; pfam03477 1075106003891 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1075106003892 LexA repressor; Validated; Region: PRK00215 1075106003893 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1075106003894 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1075106003895 Catalytic site [active] 1075106003896 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1075106003897 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1075106003898 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1075106003899 NAD binding site [chemical binding]; other site 1075106003900 dimer interface [polypeptide binding]; other site 1075106003901 substrate binding site [chemical binding]; other site 1075106003902 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106003903 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1075106003904 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1075106003905 HflX GTPase family; Region: HflX; cd01878 1075106003906 G1 box; other site 1075106003907 GTP/Mg2+ binding site [chemical binding]; other site 1075106003908 Switch I region; other site 1075106003909 G2 box; other site 1075106003910 G3 box; other site 1075106003911 Switch II region; other site 1075106003912 G4 box; other site 1075106003913 G5 box; other site 1075106003914 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1075106003915 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1075106003916 S-adenosylmethionine binding site [chemical binding]; other site 1075106003917 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1075106003918 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1075106003919 ATP binding site [chemical binding]; other site 1075106003920 putative Mg++ binding site [ion binding]; other site 1075106003921 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1075106003922 nucleotide binding region [chemical binding]; other site 1075106003923 ATP-binding site [chemical binding]; other site 1075106003924 Helicase associated domain (HA2); Region: HA2; pfam04408 1075106003925 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1075106003926 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1075106003927 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1075106003928 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1075106003929 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1075106003930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 1075106003931 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 1075106003932 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1075106003933 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1075106003934 catalytic residues [active] 1075106003935 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1075106003936 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1075106003937 putative active site [active] 1075106003938 oxyanion strand; other site 1075106003939 catalytic triad [active] 1075106003940 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1075106003941 putative active site pocket [active] 1075106003942 4-fold oligomerization interface [polypeptide binding]; other site 1075106003943 metal binding residues [ion binding]; metal-binding site 1075106003944 3-fold/trimer interface [polypeptide binding]; other site 1075106003945 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1075106003946 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106003947 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106003948 homodimer interface [polypeptide binding]; other site 1075106003949 catalytic residue [active] 1075106003950 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1075106003951 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1075106003952 NAD binding site [chemical binding]; other site 1075106003953 dimerization interface [polypeptide binding]; other site 1075106003954 product binding site; other site 1075106003955 substrate binding site [chemical binding]; other site 1075106003956 zinc binding site [ion binding]; other site 1075106003957 catalytic residues [active] 1075106003958 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1075106003959 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1075106003960 active site 1075106003961 PHP Thumb interface [polypeptide binding]; other site 1075106003962 metal binding site [ion binding]; metal-binding site 1075106003963 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1075106003964 generic binding surface I; other site 1075106003965 generic binding surface II; other site 1075106003966 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1075106003967 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1075106003968 RNA binding surface [nucleotide binding]; other site 1075106003969 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1075106003970 active site 1075106003971 lipoprotein signal peptidase; Provisional; Region: PRK14771 1075106003972 DivIVA protein; Region: DivIVA; pfam05103 1075106003973 DivIVA domain; Region: DivI1A_domain; TIGR03544 1075106003974 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1075106003975 YGGT family; Region: YGGT; pfam02325 1075106003976 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1075106003977 cell division protein FtsZ; Validated; Region: PRK09330 1075106003978 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1075106003979 nucleotide binding site [chemical binding]; other site 1075106003980 SulA interaction site; other site 1075106003981 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1075106003982 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1075106003983 FMN binding site [chemical binding]; other site 1075106003984 active site 1075106003985 catalytic residues [active] 1075106003986 substrate binding site [chemical binding]; other site 1075106003987 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1075106003988 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1075106003989 motif 1; other site 1075106003990 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1075106003991 active site 1075106003992 motif 2; other site 1075106003993 motif 3; other site 1075106003994 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1075106003995 anticodon binding site; other site 1075106003996 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1075106003997 substrate binding site [chemical binding]; other site 1075106003998 multimerization interface [polypeptide binding]; other site 1075106003999 ATP binding site [chemical binding]; other site 1075106004000 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1075106004001 thiamine phosphate binding site [chemical binding]; other site 1075106004002 active site 1075106004003 pyrophosphate binding site [ion binding]; other site 1075106004004 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1075106004005 substrate binding site [chemical binding]; other site 1075106004006 dimer interface [polypeptide binding]; other site 1075106004007 ATP binding site [chemical binding]; other site 1075106004008 Domain of unknown function DUF77; Region: DUF77; pfam01910 1075106004009 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106004010 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106004011 DNA binding site [nucleotide binding] 1075106004012 domain linker motif; other site 1075106004013 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1075106004014 putative dimerization interface [polypeptide binding]; other site 1075106004015 putative ligand binding site [chemical binding]; other site 1075106004016 galactoside permease; Reviewed; Region: lacY; PRK09528 1075106004017 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004018 putative substrate translocation pore; other site 1075106004019 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1075106004020 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1075106004021 substrate binding [chemical binding]; other site 1075106004022 active site 1075106004023 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1075106004024 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1075106004025 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004026 dimer interface [polypeptide binding]; other site 1075106004027 conserved gate region; other site 1075106004028 putative PBP binding loops; other site 1075106004029 ABC-ATPase subunit interface; other site 1075106004030 NMT1/THI5 like; Region: NMT1; pfam09084 1075106004031 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1075106004032 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1075106004033 active site 1075106004034 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 1075106004035 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1075106004036 catalytic residue [active] 1075106004037 putative FPP diphosphate binding site; other site 1075106004038 putative FPP binding hydrophobic cleft; other site 1075106004039 dimer interface [polypeptide binding]; other site 1075106004040 putative IPP diphosphate binding site; other site 1075106004041 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1075106004042 Recombination protein O N terminal; Region: RecO_N; pfam11967 1075106004043 Recombination protein O C terminal; Region: RecO_C; pfam02565 1075106004044 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1075106004045 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1075106004046 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1075106004047 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1075106004048 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1075106004049 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1075106004050 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1075106004051 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1075106004052 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1075106004053 DivIVA domain; Region: DivI1A_domain; TIGR03544 1075106004054 DivIVA domain; Region: DivI1A_domain; TIGR03544 1075106004055 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1075106004056 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1075106004057 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1075106004058 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1075106004059 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1075106004060 Part of AAA domain; Region: AAA_19; pfam13245 1075106004061 Family description; Region: UvrD_C_2; pfam13538 1075106004062 Phosphotransferase enzyme family; Region: APH; pfam01636 1075106004063 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1075106004064 substrate binding site [chemical binding]; other site 1075106004065 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1075106004066 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1075106004067 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1075106004068 active site 1075106004069 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1075106004070 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1075106004071 putative active site [active] 1075106004072 redox center [active] 1075106004073 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1075106004074 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1075106004075 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1075106004076 glutamate racemase; Provisional; Region: PRK00865 1075106004077 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1075106004078 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1075106004079 active site 1075106004080 nucleophile elbow; other site 1075106004081 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1075106004082 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1075106004083 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1075106004084 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1075106004085 substrate binding pocket [chemical binding]; other site 1075106004086 membrane-bound complex binding site; other site 1075106004087 hinge residues; other site 1075106004088 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1075106004089 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106004090 Walker A/P-loop; other site 1075106004091 ATP binding site [chemical binding]; other site 1075106004092 Q-loop/lid; other site 1075106004093 ABC transporter signature motif; other site 1075106004094 Walker B; other site 1075106004095 D-loop; other site 1075106004096 H-loop/switch region; other site 1075106004097 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1075106004098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004099 dimer interface [polypeptide binding]; other site 1075106004100 conserved gate region; other site 1075106004101 putative PBP binding loops; other site 1075106004102 ABC-ATPase subunit interface; other site 1075106004103 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1075106004104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004105 dimer interface [polypeptide binding]; other site 1075106004106 conserved gate region; other site 1075106004107 putative PBP binding loops; other site 1075106004108 ABC-ATPase subunit interface; other site 1075106004109 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1075106004110 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106004111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106004112 homodimer interface [polypeptide binding]; other site 1075106004113 catalytic residue [active] 1075106004114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004115 putative PBP binding loops; other site 1075106004116 ABC-ATPase subunit interface; other site 1075106004117 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1075106004118 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1075106004119 Walker A/P-loop; other site 1075106004120 ATP binding site [chemical binding]; other site 1075106004121 Q-loop/lid; other site 1075106004122 ABC transporter signature motif; other site 1075106004123 Walker B; other site 1075106004124 D-loop; other site 1075106004125 H-loop/switch region; other site 1075106004126 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1075106004127 NIL domain; Region: NIL; pfam09383 1075106004128 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1075106004129 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1075106004130 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1075106004131 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1075106004132 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1075106004133 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1075106004134 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1075106004135 active site 1075106004136 catalytic site [active] 1075106004137 substrate binding site [chemical binding]; other site 1075106004138 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1075106004139 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1075106004140 G1 box; other site 1075106004141 putative GEF interaction site [polypeptide binding]; other site 1075106004142 GTP/Mg2+ binding site [chemical binding]; other site 1075106004143 Switch I region; other site 1075106004144 G2 box; other site 1075106004145 G3 box; other site 1075106004146 Switch II region; other site 1075106004147 G4 box; other site 1075106004148 G5 box; other site 1075106004149 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1075106004150 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1075106004151 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1075106004152 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1075106004153 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1075106004154 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1075106004155 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004156 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106004157 putative substrate translocation pore; other site 1075106004158 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1075106004159 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1075106004160 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1075106004161 HIGH motif; other site 1075106004162 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1075106004163 active site 1075106004164 KMSKS motif; other site 1075106004165 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1075106004166 tRNA binding surface [nucleotide binding]; other site 1075106004167 anticodon binding site; other site 1075106004168 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1075106004169 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1075106004170 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1075106004171 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106004172 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1075106004173 Walker A/P-loop; other site 1075106004174 ATP binding site [chemical binding]; other site 1075106004175 Q-loop/lid; other site 1075106004176 ABC transporter signature motif; other site 1075106004177 Walker B; other site 1075106004178 D-loop; other site 1075106004179 H-loop/switch region; other site 1075106004180 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1075106004181 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106004182 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106004183 Walker A/P-loop; other site 1075106004184 ATP binding site [chemical binding]; other site 1075106004185 Q-loop/lid; other site 1075106004186 ABC transporter signature motif; other site 1075106004187 Walker B; other site 1075106004188 D-loop; other site 1075106004189 H-loop/switch region; other site 1075106004190 MarR family; Region: MarR_2; pfam12802 1075106004191 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1075106004192 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1075106004193 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1075106004194 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1075106004195 additional DNA contacts [nucleotide binding]; other site 1075106004196 mismatch recognition site; other site 1075106004197 active site 1075106004198 zinc binding site [ion binding]; other site 1075106004199 DNA intercalation site [nucleotide binding]; other site 1075106004200 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 1075106004201 FIC domain binding interface [polypeptide binding]; other site 1075106004202 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 1075106004203 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1075106004204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1075106004205 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 1075106004206 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1075106004207 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1075106004208 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1075106004209 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1075106004210 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1075106004211 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1075106004212 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1075106004213 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1075106004214 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1075106004215 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1075106004216 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1075106004217 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1075106004218 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1075106004219 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1075106004220 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1075106004221 FeS/SAM binding site; other site 1075106004222 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1075106004223 ATP cone domain; Region: ATP-cone; pfam03477 1075106004224 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1075106004225 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1075106004226 active site 1075106004227 Zn binding site [ion binding]; other site 1075106004228 glycine loop; other site 1075106004229 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1075106004230 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1075106004231 generic binding surface II; other site 1075106004232 generic binding surface I; other site 1075106004233 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1075106004234 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1075106004235 putative catalytic site [active] 1075106004236 putative metal binding site [ion binding]; other site 1075106004237 putative phosphate binding site [ion binding]; other site 1075106004238 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 1075106004239 aminotransferase; Validated; Region: PRK07337 1075106004240 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1075106004241 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106004242 homodimer interface [polypeptide binding]; other site 1075106004243 catalytic residue [active] 1075106004244 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1075106004245 additional DNA contacts [nucleotide binding]; other site 1075106004246 mismatch recognition site; other site 1075106004247 active site 1075106004248 zinc binding site [ion binding]; other site 1075106004249 DNA intercalation site [nucleotide binding]; other site 1075106004250 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1075106004251 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1075106004252 active site 1075106004253 catalytic site [active] 1075106004254 substrate binding site [chemical binding]; other site 1075106004255 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1075106004256 active site 1075106004257 catalytic residues [active] 1075106004258 metal binding site [ion binding]; metal-binding site 1075106004259 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1075106004260 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1075106004261 active site 1075106004262 substrate binding site [chemical binding]; other site 1075106004263 metal binding site [ion binding]; metal-binding site 1075106004264 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1075106004265 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1075106004266 Zn binding site [ion binding]; other site 1075106004267 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1075106004268 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1075106004269 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1075106004270 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1075106004271 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1075106004272 dimer interface [polypeptide binding]; other site 1075106004273 active site 1075106004274 catalytic residue [active] 1075106004275 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1075106004276 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1075106004277 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1075106004278 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106004279 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004280 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1075106004281 Coenzyme A binding pocket [chemical binding]; other site 1075106004282 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1075106004283 Family description; Region: UvrD_C_2; pfam13538 1075106004284 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1075106004285 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1075106004286 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106004287 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1075106004288 active site 1075106004289 ATP binding site [chemical binding]; other site 1075106004290 substrate binding site [chemical binding]; other site 1075106004291 activation loop (A-loop); other site 1075106004292 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1075106004293 Interdomain contacts; other site 1075106004294 Cytokine receptor motif; other site 1075106004295 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1075106004296 Interdomain contacts; other site 1075106004297 Cytokine receptor motif; other site 1075106004298 MoxR-like ATPases [General function prediction only]; Region: COG0714 1075106004299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106004300 Walker A motif; other site 1075106004301 ATP binding site [chemical binding]; other site 1075106004302 Walker B motif; other site 1075106004303 arginine finger; other site 1075106004304 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1075106004305 Protein of unknown function DUF58; Region: DUF58; pfam01882 1075106004306 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1075106004307 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1075106004308 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1075106004309 phosphopeptide binding site; other site 1075106004310 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1075106004311 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1075106004312 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1075106004313 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1075106004314 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1075106004315 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1075106004316 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1075106004317 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1075106004318 DNA binding site [nucleotide binding] 1075106004319 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1075106004320 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1075106004321 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1075106004322 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1075106004323 RPB1 interaction site [polypeptide binding]; other site 1075106004324 RPB10 interaction site [polypeptide binding]; other site 1075106004325 RPB11 interaction site [polypeptide binding]; other site 1075106004326 RPB3 interaction site [polypeptide binding]; other site 1075106004327 RPB12 interaction site [polypeptide binding]; other site 1075106004328 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1075106004329 endonuclease III; Region: ENDO3c; smart00478 1075106004330 minor groove reading motif; other site 1075106004331 helix-hairpin-helix signature motif; other site 1075106004332 substrate binding pocket [chemical binding]; other site 1075106004333 active site 1075106004334 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1075106004335 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1075106004336 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1075106004337 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1075106004338 active site 1075106004339 catalytic site [active] 1075106004340 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1075106004341 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1075106004342 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1075106004343 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1075106004344 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1075106004345 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1075106004346 dimer interface [polypeptide binding]; other site 1075106004347 active site 1075106004348 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1075106004349 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1075106004350 DNA-binding site [nucleotide binding]; DNA binding site 1075106004351 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1075106004352 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1075106004353 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1075106004354 Ligand binding site; other site 1075106004355 Putative Catalytic site; other site 1075106004356 DXD motif; other site 1075106004357 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1075106004358 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1075106004359 quinone interaction residues [chemical binding]; other site 1075106004360 active site 1075106004361 catalytic residues [active] 1075106004362 FMN binding site [chemical binding]; other site 1075106004363 substrate binding site [chemical binding]; other site 1075106004364 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1075106004365 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1075106004366 active site 1075106004367 FMN binding site [chemical binding]; other site 1075106004368 substrate binding site [chemical binding]; other site 1075106004369 homotetramer interface [polypeptide binding]; other site 1075106004370 catalytic residue [active] 1075106004371 Transglycosylase; Region: Transgly; pfam00912 1075106004372 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1075106004373 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1075106004374 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1075106004375 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1075106004376 ligand binding site [chemical binding]; other site 1075106004377 flexible hinge region; other site 1075106004378 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1075106004379 putative switch regulator; other site 1075106004380 non-specific DNA interactions [nucleotide binding]; other site 1075106004381 DNA binding site [nucleotide binding] 1075106004382 sequence specific DNA binding site [nucleotide binding]; other site 1075106004383 putative cAMP binding site [chemical binding]; other site 1075106004384 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1075106004385 TM2 domain; Region: TM2; pfam05154 1075106004386 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1075106004387 tartrate dehydrogenase; Region: TTC; TIGR02089 1075106004388 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1075106004389 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1075106004390 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1075106004391 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1075106004392 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1075106004393 lipoyl attachment site [posttranslational modification]; other site 1075106004394 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1075106004395 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1075106004396 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1075106004397 putative NADH binding site [chemical binding]; other site 1075106004398 putative active site [active] 1075106004399 nudix motif; other site 1075106004400 putative metal binding site [ion binding]; other site 1075106004401 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1075106004402 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1075106004403 nudix motif; other site 1075106004404 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1075106004405 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1075106004406 catalytic residues [active] 1075106004407 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1075106004408 G5 domain; Region: G5; pfam07501 1075106004409 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1075106004410 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1075106004411 catalytic residue [active] 1075106004412 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1075106004413 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1075106004414 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1075106004415 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1075106004416 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1075106004417 Ligand binding site; other site 1075106004418 Putative Catalytic site; other site 1075106004419 DXD motif; other site 1075106004420 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1075106004421 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1075106004422 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1075106004423 substrate binding site; other site 1075106004424 tetramer interface; other site 1075106004425 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1075106004426 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1075106004427 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1075106004428 NADP binding site [chemical binding]; other site 1075106004429 active site 1075106004430 putative substrate binding site [chemical binding]; other site 1075106004431 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1075106004432 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1075106004433 NAD binding site [chemical binding]; other site 1075106004434 substrate binding site [chemical binding]; other site 1075106004435 homodimer interface [polypeptide binding]; other site 1075106004436 active site 1075106004437 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1075106004438 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1075106004439 Probable Catalytic site; other site 1075106004440 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1075106004441 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1075106004442 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1075106004443 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004444 active site 1075106004445 putative glycosyl transferase; Provisional; Region: PRK10073 1075106004446 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1075106004447 active site 1075106004448 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004449 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1075106004450 active site 1075106004451 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1075106004452 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106004453 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1075106004454 active site 1075106004455 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1075106004456 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1075106004457 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1075106004458 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1075106004459 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1075106004460 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1075106004461 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1075106004462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004463 active site 1075106004464 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1075106004465 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1075106004466 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1075106004467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106004468 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004469 putative substrate translocation pore; other site 1075106004470 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004471 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1075106004472 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1075106004473 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1075106004474 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1075106004475 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1075106004476 active site 1075106004477 multimer interface [polypeptide binding]; other site 1075106004478 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1075106004479 predicted active site [active] 1075106004480 catalytic triad [active] 1075106004481 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1075106004482 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1075106004483 putative NAD(P) binding site [chemical binding]; other site 1075106004484 active site 1075106004485 putative substrate binding site [chemical binding]; other site 1075106004486 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1075106004487 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1075106004488 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1075106004489 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004490 active site 1075106004491 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 1075106004492 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1075106004493 Ligand binding site; other site 1075106004494 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1075106004495 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1075106004496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106004497 Walker A/P-loop; other site 1075106004498 ATP binding site [chemical binding]; other site 1075106004499 Q-loop/lid; other site 1075106004500 ABC transporter signature motif; other site 1075106004501 Walker B; other site 1075106004502 D-loop; other site 1075106004503 H-loop/switch region; other site 1075106004504 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106004505 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106004506 Walker A/P-loop; other site 1075106004507 ATP binding site [chemical binding]; other site 1075106004508 Q-loop/lid; other site 1075106004509 ABC transporter signature motif; other site 1075106004510 Walker B; other site 1075106004511 D-loop; other site 1075106004512 H-loop/switch region; other site 1075106004513 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1075106004514 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1075106004515 acyl-activating enzyme (AAE) consensus motif; other site 1075106004516 putative AMP binding site [chemical binding]; other site 1075106004517 putative active site [active] 1075106004518 putative CoA binding site [chemical binding]; other site 1075106004519 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1075106004520 putative active site [active] 1075106004521 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1075106004522 dimer interface [polypeptide binding]; other site 1075106004523 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1075106004524 nudix motif; other site 1075106004525 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1075106004526 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1075106004527 active site 1075106004528 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1075106004529 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1075106004530 Chain length determinant protein; Region: Wzz; cl15801 1075106004531 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1075106004532 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1075106004533 Nucleotide binding site [chemical binding]; other site 1075106004534 DTAP/Switch II; other site 1075106004535 Switch I; other site 1075106004536 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1075106004537 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1075106004538 homoserine kinase; Provisional; Region: PRK01212 1075106004539 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1075106004540 homoserine dehydrogenase; Provisional; Region: PRK06349 1075106004541 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1075106004542 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1075106004543 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1075106004544 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1075106004545 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1075106004546 catalytic residue [active] 1075106004547 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1075106004548 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1075106004549 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1075106004550 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1075106004551 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1075106004552 active site 1075106004553 HIGH motif; other site 1075106004554 KMSK motif region; other site 1075106004555 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1075106004556 tRNA binding surface [nucleotide binding]; other site 1075106004557 anticodon binding site; other site 1075106004558 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1075106004559 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1075106004560 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1075106004561 homotrimer interaction site [polypeptide binding]; other site 1075106004562 putative active site [active] 1075106004563 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106004564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004565 dimer interface [polypeptide binding]; other site 1075106004566 conserved gate region; other site 1075106004567 putative PBP binding loops; other site 1075106004568 ABC-ATPase subunit interface; other site 1075106004569 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1075106004570 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1075106004571 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1075106004572 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1075106004573 hypothetical protein; Provisional; Region: PRK03298 1075106004574 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1075106004575 gamma subunit interface [polypeptide binding]; other site 1075106004576 epsilon subunit interface [polypeptide binding]; other site 1075106004577 LBP interface [polypeptide binding]; other site 1075106004578 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1075106004579 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1075106004580 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1075106004581 alpha subunit interaction interface [polypeptide binding]; other site 1075106004582 Walker A motif; other site 1075106004583 ATP binding site [chemical binding]; other site 1075106004584 Walker B motif; other site 1075106004585 inhibitor binding site; inhibition site 1075106004586 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1075106004587 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1075106004588 core domain interface [polypeptide binding]; other site 1075106004589 delta subunit interface [polypeptide binding]; other site 1075106004590 epsilon subunit interface [polypeptide binding]; other site 1075106004591 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1075106004592 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1075106004593 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1075106004594 beta subunit interaction interface [polypeptide binding]; other site 1075106004595 Walker A motif; other site 1075106004596 ATP binding site [chemical binding]; other site 1075106004597 Walker B motif; other site 1075106004598 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1075106004599 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1075106004600 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1075106004601 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1075106004602 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1075106004603 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1075106004604 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1075106004605 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1075106004606 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1075106004607 proposed active site lysine [active] 1075106004608 conserved cys residue [active] 1075106004609 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106004610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004611 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1075106004612 active site 1075106004613 tetramer interface [polypeptide binding]; other site 1075106004614 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1075106004615 Plasmid replication protein; Region: Rep_2; pfam01719 1075106004616 Protein of unknown function DUF262; Region: DUF262; pfam03235 1075106004617 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1075106004618 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1075106004619 active site 1075106004620 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 1075106004621 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1075106004622 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1075106004623 Int/Topo IB signature motif; other site 1075106004624 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1075106004625 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1075106004626 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1075106004627 Cellulose or protein binding domain; Region: CBM_10; pfam02013 1075106004628 Membrane transport protein; Region: Mem_trans; cl09117 1075106004629 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1075106004630 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1075106004631 PYR/PP interface [polypeptide binding]; other site 1075106004632 dimer interface [polypeptide binding]; other site 1075106004633 TPP binding site [chemical binding]; other site 1075106004634 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1075106004635 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1075106004636 TPP-binding site; other site 1075106004637 dimer interface [polypeptide binding]; other site 1075106004638 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1075106004639 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1075106004640 Cl- selectivity filter; other site 1075106004641 Cl- binding residues [ion binding]; other site 1075106004642 pore gating glutamate residue; other site 1075106004643 dimer interface [polypeptide binding]; other site 1075106004644 TQXA domain; Region: TQXA_dom; TIGR03934 1075106004645 Cna protein B-type domain; Region: Cna_B; pfam05738 1075106004646 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1075106004647 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1075106004648 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1075106004649 active site 1075106004650 catalytic site [active] 1075106004651 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1075106004652 dimer interface [polypeptide binding]; other site 1075106004653 substrate binding site [chemical binding]; other site 1075106004654 metal binding sites [ion binding]; metal-binding site 1075106004655 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1075106004656 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1075106004657 DNA binding site [nucleotide binding] 1075106004658 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1075106004659 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1075106004660 minor groove reading motif; other site 1075106004661 helix-hairpin-helix signature motif; other site 1075106004662 substrate binding pocket [chemical binding]; other site 1075106004663 active site 1075106004664 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1075106004665 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1075106004666 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1075106004667 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1075106004668 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106004669 active site 1075106004670 HIGH motif; other site 1075106004671 nucleotide binding site [chemical binding]; other site 1075106004672 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1075106004673 active site 1075106004674 KMSKS motif; other site 1075106004675 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1075106004676 tRNA binding surface [nucleotide binding]; other site 1075106004677 anticodon binding site; other site 1075106004678 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1075106004679 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1075106004680 dimerization interface [polypeptide binding]; other site 1075106004681 putative Zn2+ binding site [ion binding]; other site 1075106004682 putative DNA binding site [nucleotide binding]; other site 1075106004683 chorismate mutase; Provisional; Region: PRK09239 1075106004684 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1075106004685 transcription termination factor Rho; Provisional; Region: PRK12608 1075106004686 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1075106004687 RNA binding site [nucleotide binding]; other site 1075106004688 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1075106004689 Walker A motif; other site 1075106004690 ATP binding site [chemical binding]; other site 1075106004691 Walker B motif; other site 1075106004692 hypothetical protein; Provisional; Region: PRK07208 1075106004693 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1075106004694 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1075106004695 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1075106004696 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1075106004697 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1075106004698 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1075106004699 GatB domain; Region: GatB_Yqey; pfam02637 1075106004700 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1075106004701 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1075106004702 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1075106004703 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1075106004704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106004705 ABC transporter signature motif; other site 1075106004706 Walker B; other site 1075106004707 D-loop; other site 1075106004708 H-loop/switch region; other site 1075106004709 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1075106004710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1075106004711 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1075106004712 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106004713 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1075106004714 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1075106004715 Clp amino terminal domain; Region: Clp_N; pfam02861 1075106004716 Clp amino terminal domain; Region: Clp_N; pfam02861 1075106004717 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106004718 Walker A motif; other site 1075106004719 ATP binding site [chemical binding]; other site 1075106004720 Walker B motif; other site 1075106004721 arginine finger; other site 1075106004722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1075106004723 Walker A motif; other site 1075106004724 ATP binding site [chemical binding]; other site 1075106004725 Walker B motif; other site 1075106004726 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1075106004727 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1075106004728 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1075106004729 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1075106004730 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1075106004731 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1075106004732 metal ion-dependent adhesion site (MIDAS); other site 1075106004733 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1075106004734 active site 1075106004735 catalytic site [active] 1075106004736 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1075106004737 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1075106004738 catalytic residue [active] 1075106004739 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1075106004740 active site 1075106004741 HIGH motif; other site 1075106004742 nucleotide binding site [chemical binding]; other site 1075106004743 active site 1075106004744 KMSKS motif; other site 1075106004745 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1075106004746 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1075106004747 amphipathic channel; other site 1075106004748 Asn-Pro-Ala signature motifs; other site 1075106004749 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1075106004750 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1075106004751 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1075106004752 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1075106004753 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1075106004754 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1075106004755 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1075106004756 dimer interface [polypeptide binding]; other site 1075106004757 ssDNA binding site [nucleotide binding]; other site 1075106004758 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1075106004759 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1075106004760 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1075106004761 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1075106004762 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1075106004763 active site 1075106004764 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1075106004765 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1075106004766 substrate binding site [chemical binding]; other site 1075106004767 dimer interface [polypeptide binding]; other site 1075106004768 ATP binding site [chemical binding]; other site 1075106004769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1075106004770 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1075106004771 putative substrate translocation pore; other site 1075106004772 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1075106004773 active site 1075106004774 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106004775 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106004776 DNA binding site [nucleotide binding] 1075106004777 domain linker motif; other site 1075106004778 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106004779 dimerization interface [polypeptide binding]; other site 1075106004780 ligand binding site [chemical binding]; other site 1075106004781 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1075106004782 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1075106004783 UDP-galactopyranose mutase; Region: GLF; pfam03275 1075106004784 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106004785 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004786 active site 1075106004787 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1075106004788 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004789 active site 1075106004790 Sulfatase; Region: Sulfatase; pfam00884 1075106004791 Sulfatase; Region: Sulfatase; pfam00884 1075106004792 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1075106004793 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004794 active site 1075106004795 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1075106004796 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1075106004797 active site 1075106004798 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1075106004799 active site 1075106004800 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1075106004801 S-layer homology domain; Region: SLH; pfam00395 1075106004802 S-layer homology domain; Region: SLH; pfam00395 1075106004803 S-layer homology domain; Region: SLH; pfam00395 1075106004804 MULE transposase domain; Region: MULE; pfam10551 1075106004805 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1075106004806 Leucine rich repeat; Region: LRR_8; pfam13855 1075106004807 S-layer homology domain; Region: SLH; pfam00395 1075106004808 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1075106004809 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1075106004810 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1075106004811 Walker A/P-loop; other site 1075106004812 ATP binding site [chemical binding]; other site 1075106004813 Q-loop/lid; other site 1075106004814 ABC transporter signature motif; other site 1075106004815 Walker B; other site 1075106004816 D-loop; other site 1075106004817 H-loop/switch region; other site 1075106004818 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1075106004819 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1075106004820 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1075106004821 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1075106004822 active site 1075106004823 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1075106004824 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1075106004825 FtsX-like permease family; Region: FtsX; pfam02687 1075106004826 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1075106004827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106004828 ATP binding site [chemical binding]; other site 1075106004829 Q-loop/lid; other site 1075106004830 ABC transporter signature motif; other site 1075106004831 Walker B; other site 1075106004832 D-loop; other site 1075106004833 H-loop/switch region; other site 1075106004834 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1075106004835 Zn2+ binding site [ion binding]; other site 1075106004836 Mg2+ binding site [ion binding]; other site 1075106004837 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1075106004838 putative active site [active] 1075106004839 putative dimer interface [polypeptide binding]; other site 1075106004840 YL1 nuclear protein; Region: YL1; pfam05764 1075106004841 K+ potassium transporter; Region: K_trans; pfam02705 1075106004842 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1075106004843 active site 1075106004844 Melibiase; Region: Melibiase; pfam02065 1075106004845 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106004846 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1075106004847 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1075106004848 Walker A/P-loop; other site 1075106004849 ATP binding site [chemical binding]; other site 1075106004850 Q-loop/lid; other site 1075106004851 ABC transporter signature motif; other site 1075106004852 Walker B; other site 1075106004853 D-loop; other site 1075106004854 H-loop/switch region; other site 1075106004855 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1075106004856 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1075106004857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1075106004858 Walker A/P-loop; other site 1075106004859 ATP binding site [chemical binding]; other site 1075106004860 Q-loop/lid; other site 1075106004861 ABC transporter signature motif; other site 1075106004862 Walker B; other site 1075106004863 D-loop; other site 1075106004864 H-loop/switch region; other site 1075106004865 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1075106004866 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1075106004867 active site 1075106004868 HIGH motif; other site 1075106004869 KMSKS motif; other site 1075106004870 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1075106004871 tRNA binding surface [nucleotide binding]; other site 1075106004872 anticodon binding site; other site 1075106004873 Predicted methyltransferases [General function prediction only]; Region: COG0313 1075106004874 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1075106004875 putative SAM binding site [chemical binding]; other site 1075106004876 putative homodimer interface [polypeptide binding]; other site 1075106004877 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1075106004878 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1075106004879 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1075106004880 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1075106004881 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1075106004882 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1075106004883 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1075106004884 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1075106004885 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1075106004886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1075106004887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1075106004888 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1075106004889 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1075106004890 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106004891 motif II; other site 1075106004892 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1075106004893 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1075106004894 DNA binding residues [nucleotide binding] 1075106004895 putative dimer interface [polypeptide binding]; other site 1075106004896 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1075106004897 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1075106004898 HSP70 interaction site [polypeptide binding]; other site 1075106004899 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1075106004900 substrate binding site [polypeptide binding]; other site 1075106004901 dimer interface [polypeptide binding]; other site 1075106004902 GrpE; Region: GrpE; pfam01025 1075106004903 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1075106004904 dimer interface [polypeptide binding]; other site 1075106004905 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1075106004906 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1075106004907 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1075106004908 nucleotide binding site [chemical binding]; other site 1075106004909 NEF interaction site [polypeptide binding]; other site 1075106004910 SBD interface [polypeptide binding]; other site 1075106004911 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106004912 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106004913 DNA binding site [nucleotide binding] 1075106004914 domain linker motif; other site 1075106004915 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106004916 ligand binding site [chemical binding]; other site 1075106004917 dimerization interface [polypeptide binding]; other site 1075106004918 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1075106004919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106004920 motif II; other site 1075106004921 pullulanase, type I; Region: pulA_typeI; TIGR02104 1075106004922 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1075106004923 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1075106004924 Ca binding site [ion binding]; other site 1075106004925 active site 1075106004926 catalytic site [active] 1075106004927 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106004928 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004929 dimer interface [polypeptide binding]; other site 1075106004930 conserved gate region; other site 1075106004931 putative PBP binding loops; other site 1075106004932 ABC-ATPase subunit interface; other site 1075106004933 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1075106004934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004935 dimer interface [polypeptide binding]; other site 1075106004936 conserved gate region; other site 1075106004937 putative PBP binding loops; other site 1075106004938 ABC-ATPase subunit interface; other site 1075106004939 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1075106004940 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1075106004941 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1075106004942 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1075106004943 active site 1075106004944 catalytic site [active] 1075106004945 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1075106004946 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1075106004947 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1075106004948 Protein of unknown function, DUF624; Region: DUF624; cl02369 1075106004949 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106004950 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004951 dimer interface [polypeptide binding]; other site 1075106004952 conserved gate region; other site 1075106004953 putative PBP binding loops; other site 1075106004954 ABC-ATPase subunit interface; other site 1075106004955 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106004956 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106004957 dimer interface [polypeptide binding]; other site 1075106004958 conserved gate region; other site 1075106004959 putative PBP binding loops; other site 1075106004960 ABC-ATPase subunit interface; other site 1075106004961 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106004962 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106004963 DNA binding site [nucleotide binding] 1075106004964 domain linker motif; other site 1075106004965 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106004966 ligand binding site [chemical binding]; other site 1075106004967 dimerization interface [polypeptide binding]; other site 1075106004968 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1075106004969 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1075106004970 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1075106004971 active site 1075106004972 catalytic site [active] 1075106004973 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1075106004974 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106004975 catalytic core [active] 1075106004976 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1075106004977 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1075106004978 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1075106004979 dimer interface [polypeptide binding]; other site 1075106004980 FMN binding site [chemical binding]; other site 1075106004981 NADPH bind site [chemical binding]; other site 1075106004982 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1075106004983 RelB antitoxin; Region: RelB; cl01171 1075106004984 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1075106004985 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1075106004986 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1075106004987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1075106004988 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1075106004989 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1075106004990 DNA binding site [nucleotide binding] 1075106004991 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1075106004992 dimerization interface [polypeptide binding]; other site 1075106004993 ligand binding site [chemical binding]; other site 1075106004994 NAD-dependent deacetylase; Provisional; Region: PRK00481 1075106004995 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1075106004996 threonine dehydratase; Provisional; Region: PRK08198 1075106004997 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1075106004998 tetramer interface [polypeptide binding]; other site 1075106004999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1075106005000 catalytic residue [active] 1075106005001 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1075106005002 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1075106005003 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1075106005004 Ca binding site [ion binding]; other site 1075106005005 active site 1075106005006 catalytic site [active] 1075106005007 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1075106005008 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; pfam05691 1075106005009 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1075106005010 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106005011 dimer interface [polypeptide binding]; other site 1075106005012 conserved gate region; other site 1075106005013 putative PBP binding loops; other site 1075106005014 ABC-ATPase subunit interface; other site 1075106005015 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1075106005016 dimer interface [polypeptide binding]; other site 1075106005017 conserved gate region; other site 1075106005018 putative PBP binding loops; other site 1075106005019 ABC-ATPase subunit interface; other site 1075106005020 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1075106005021 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1075106005022 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1075106005023 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1075106005024 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1075106005025 Melibiase; Region: Melibiase; pfam02065 1075106005026 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1075106005027 nucleoside/Zn binding site; other site 1075106005028 dimer interface [polypeptide binding]; other site 1075106005029 catalytic motif [active] 1075106005030 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1075106005031 Predicted esterase [General function prediction only]; Region: COG0400 1075106005032 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1075106005033 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1075106005034 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1075106005035 trimer interface [polypeptide binding]; other site 1075106005036 active site 1075106005037 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1075106005038 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1075106005039 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1075106005040 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1075106005041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1075106005042 motif II; other site 1075106005043 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1075106005044 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1075106005045 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1075106005046 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1075106005047 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1075106005048 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1075106005049 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1075106005050 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1075106005051 Walker A/P-loop; other site 1075106005052 ATP binding site [chemical binding]; other site 1075106005053 Q-loop/lid; other site 1075106005054 ABC transporter signature motif; other site 1075106005055 Walker B; other site 1075106005056 D-loop; other site 1075106005057 H-loop/switch region; other site 1075106005058 TOBE domain; Region: TOBE_2; pfam08402 1075106005059 Ion channel; Region: Ion_trans_2; pfam07885 1075106005060 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1075106005061 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1075106005062 active site 1075106005063 ATP binding site [chemical binding]; other site 1075106005064 substrate binding site [chemical binding]; other site 1075106005065 activation loop (A-loop); other site 1075106005066 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1075106005067 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1075106005068 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1075106005069 G5 domain; Region: G5; pfam07501 1075106005070 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1075106005071 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1075106005072 catalytic residue [active] 1075106005073 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1075106005074 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1075106005075 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1075106005076 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1075106005077 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1075106005078 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1075106005079 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1075106005080 active site 1075106005081 NTP binding site [chemical binding]; other site 1075106005082 metal binding triad [ion binding]; metal-binding site 1075106005083 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1075106005084 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1075106005085 Zn2+ binding site [ion binding]; other site 1075106005086 Mg2+ binding site [ion binding]; other site 1075106005087 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1075106005088 active site 1075106005089 Ap6A binding site [chemical binding]; other site 1075106005090 nudix motif; other site 1075106005091 metal binding site [ion binding]; metal-binding site 1075106005092 integral membrane protein MviN; Region: mviN; TIGR01695 1075106005093 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1075106005094 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1075106005095 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1075106005096 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1075106005097 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1075106005098 ParB-like nuclease domain; Region: ParB; smart00470 1075106005099 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1075106005100 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1075106005101 P-loop; other site 1075106005102 Magnesium ion binding site [ion binding]; other site 1075106005103 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1075106005104 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1075106005105 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1075106005106 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1075106005107 G-X-X-G motif; other site 1075106005108 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1075106005109 RxxxH motif; other site 1075106005110 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1075106005111 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1075106005112 IncFII RepA protein family; Region: IncFII_repA; cl11495 1075106005113 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1075106005114 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399