-- dump date 20140619_001931 -- class Genbank::misc_feature -- table misc_feature_note -- id note 742729000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 742729000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729000003 Walker A motif; other site 742729000004 ATP binding site [chemical binding]; other site 742729000005 Walker B motif; other site 742729000006 arginine finger; other site 742729000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 742729000008 DnaA box-binding interface [nucleotide binding]; other site 742729000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 742729000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 742729000011 putative DNA binding surface [nucleotide binding]; other site 742729000012 dimer interface [polypeptide binding]; other site 742729000013 beta-clamp/clamp loader binding surface; other site 742729000014 beta-clamp/translesion DNA polymerase binding surface; other site 742729000015 recombination protein F; Reviewed; Region: recF; PRK00064 742729000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000017 Walker A/P-loop; other site 742729000018 ATP binding site [chemical binding]; other site 742729000019 Q-loop/lid; other site 742729000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000021 ABC transporter signature motif; other site 742729000022 Walker B; other site 742729000023 D-loop; other site 742729000024 H-loop/switch region; other site 742729000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 742729000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 742729000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 742729000028 Mg2+ binding site [ion binding]; other site 742729000029 G-X-G motif; other site 742729000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 742729000031 anchoring element; other site 742729000032 dimer interface [polypeptide binding]; other site 742729000033 ATP binding site [chemical binding]; other site 742729000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 742729000035 active site 742729000036 putative metal-binding site [ion binding]; other site 742729000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 742729000038 DNA gyrase subunit A; Validated; Region: PRK05560 742729000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 742729000040 CAP-like domain; other site 742729000041 active site 742729000042 primary dimer interface [polypeptide binding]; other site 742729000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 742729000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 742729000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 742729000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 742729000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 742729000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 742729000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 742729000050 VanZ like family; Region: VanZ; cl01971 742729000051 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 742729000052 Haemolysin-III related; Region: HlyIII; pfam03006 742729000053 glutamate dehydrogenase; Provisional; Region: PRK09414 742729000054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 742729000055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 742729000056 NAD(P) binding site [chemical binding]; other site 742729000057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729000059 putative substrate translocation pore; other site 742729000060 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 742729000061 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 742729000062 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 742729000063 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 742729000064 Protein of unknown function DUF45; Region: DUF45; pfam01863 742729000065 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 742729000066 MarR family; Region: MarR_2; pfam12802 742729000067 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 742729000068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 742729000069 non-specific DNA interactions [nucleotide binding]; other site 742729000070 DNA binding site [nucleotide binding] 742729000071 sequence specific DNA binding site [nucleotide binding]; other site 742729000072 putative cAMP binding site [chemical binding]; other site 742729000073 6-phosphogluconolactonase; Provisional; Region: PRK11028 742729000074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000075 Walker A/P-loop; other site 742729000076 ATP binding site [chemical binding]; other site 742729000077 Q-loop/lid; other site 742729000078 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 742729000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000080 ABC transporter signature motif; other site 742729000081 Walker B; other site 742729000082 D-loop; other site 742729000083 H-loop/switch region; other site 742729000084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000085 Walker A/P-loop; other site 742729000086 ATP binding site [chemical binding]; other site 742729000087 Q-loop/lid; other site 742729000088 ABC transporter signature motif; other site 742729000089 Walker B; other site 742729000090 D-loop; other site 742729000091 H-loop/switch region; other site 742729000092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 742729000093 S-adenosylmethionine binding site [chemical binding]; other site 742729000094 Predicted flavoprotein [General function prediction only]; Region: COG0431 742729000095 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 742729000096 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 742729000097 homodimer interface [polypeptide binding]; other site 742729000098 chemical substrate binding site [chemical binding]; other site 742729000099 oligomer interface [polypeptide binding]; other site 742729000100 metal binding site [ion binding]; metal-binding site 742729000101 Helix-turn-helix domain; Region: HTH_17; pfam12728 742729000102 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 742729000103 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 742729000104 cofactor binding site; other site 742729000105 DNA binding site [nucleotide binding] 742729000106 substrate interaction site [chemical binding]; other site 742729000107 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 742729000108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 742729000109 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 742729000110 PemK-like protein; Region: PemK; cl00995 742729000111 Transcriptional regulator [Transcription]; Region: LysR; COG0583 742729000112 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 742729000113 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 742729000114 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 742729000115 catalytic tetrad [active] 742729000116 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 742729000117 active site 742729000118 catalytic tetrad [active] 742729000119 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 742729000120 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 742729000121 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 742729000122 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 742729000123 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 742729000124 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 742729000125 Phosphotransferase enzyme family; Region: APH; pfam01636 742729000126 substrate binding site [chemical binding]; other site 742729000127 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 742729000128 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 742729000129 Transposase; Region: DDE_Tnp_ISL3; pfam01610 742729000130 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 742729000131 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 742729000132 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 742729000133 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 742729000134 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 742729000135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729000136 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729000137 putative substrate translocation pore; other site 742729000138 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 742729000139 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 742729000140 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 742729000141 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 742729000142 dimerization interface [polypeptide binding]; other site 742729000143 DPS ferroxidase diiron center [ion binding]; other site 742729000144 ion pore; other site 742729000145 Domain of unknown function DUF21; Region: DUF21; pfam01595 742729000146 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 742729000147 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 742729000148 Transporter associated domain; Region: CorC_HlyC; smart01091 742729000149 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 742729000150 active site clefts [active] 742729000151 zinc binding site [ion binding]; other site 742729000152 dimer interface [polypeptide binding]; other site 742729000153 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729000154 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729000155 DNA binding site [nucleotide binding] 742729000156 domain linker motif; other site 742729000157 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 742729000158 ligand binding site [chemical binding]; other site 742729000159 dimerization interface (open form) [polypeptide binding]; other site 742729000160 dimerization interface (closed form) [polypeptide binding]; other site 742729000161 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 742729000162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000163 ABC transporter; Region: ABC_tran; pfam00005 742729000164 Q-loop/lid; other site 742729000165 ABC transporter signature motif; other site 742729000166 Walker B; other site 742729000167 D-loop; other site 742729000168 H-loop/switch region; other site 742729000169 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729000170 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729000171 DNA binding site [nucleotide binding] 742729000172 domain linker motif; other site 742729000173 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 742729000174 ligand binding site [chemical binding]; other site 742729000175 dimerization interface [polypeptide binding]; other site 742729000176 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 742729000177 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 742729000178 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 742729000179 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 742729000180 putative N- and C-terminal domain interface [polypeptide binding]; other site 742729000181 putative active site [active] 742729000182 MgATP binding site [chemical binding]; other site 742729000183 catalytic site [active] 742729000184 metal binding site [ion binding]; metal-binding site 742729000185 putative carbohydrate binding site [chemical binding]; other site 742729000186 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 742729000187 intersubunit interface [polypeptide binding]; other site 742729000188 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 742729000189 active site 742729000190 Zn2+ binding site [ion binding]; other site 742729000191 L-arabinose isomerase; Provisional; Region: PRK02929 742729000192 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 742729000193 hexamer (dimer of trimers) interface [polypeptide binding]; other site 742729000194 trimer interface [polypeptide binding]; other site 742729000195 substrate binding site [chemical binding]; other site 742729000196 Mn binding site [ion binding]; other site 742729000197 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 742729000198 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 742729000199 active site 742729000200 catalytic tetrad [active] 742729000201 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 742729000202 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 742729000203 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 742729000204 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 742729000205 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 742729000206 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 742729000207 Transposase; Region: DDE_Tnp_ISL3; pfam01610 742729000208 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 742729000209 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 742729000210 active site 742729000211 HIGH motif; other site 742729000212 dimer interface [polypeptide binding]; other site 742729000213 KMSKS motif; other site 742729000214 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 742729000215 homodimer interface [polypeptide binding]; other site 742729000216 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 742729000217 active site pocket [active] 742729000218 Rhomboid family; Region: Rhomboid; pfam01694 742729000219 Methyltransferase domain; Region: Methyltransf_26; pfam13659 742729000220 putative septation inhibitor protein; Reviewed; Region: PRK02251 742729000221 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 742729000222 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 742729000223 active site 742729000224 catalytic site [active] 742729000225 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 742729000226 Glutamine amidotransferase class-I; Region: GATase; pfam00117 742729000227 glutamine binding [chemical binding]; other site 742729000228 catalytic triad [active] 742729000229 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 742729000230 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 742729000231 active site 742729000232 ATP binding site [chemical binding]; other site 742729000233 substrate binding site [chemical binding]; other site 742729000234 activation loop (A-loop); other site 742729000235 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 742729000236 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 742729000237 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 742729000238 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 742729000239 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 742729000240 Catalytic domain of Protein Kinases; Region: PKc; cd00180 742729000241 active site 742729000242 ATP binding site [chemical binding]; other site 742729000243 substrate binding site [chemical binding]; other site 742729000244 activation loop (A-loop); other site 742729000245 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 742729000246 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 742729000247 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 742729000248 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 742729000249 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 742729000250 active site 742729000251 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 742729000252 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 742729000253 phosphopeptide binding site; other site 742729000254 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 742729000255 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 742729000256 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 742729000257 phosphopeptide binding site; other site 742729000258 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 742729000259 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 742729000260 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 742729000261 EamA-like transporter family; Region: EamA; pfam00892 742729000262 EamA-like transporter family; Region: EamA; pfam00892 742729000263 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 742729000264 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 742729000265 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 742729000266 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 742729000267 S-adenosylmethionine binding site [chemical binding]; other site 742729000268 Predicted membrane protein [Function unknown]; Region: COG2261 742729000269 ferredoxin-NADP+ reductase; Region: PLN02852 742729000270 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 742729000271 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 742729000272 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 742729000273 Soluble P-type ATPase [General function prediction only]; Region: COG4087 742729000274 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 742729000275 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 742729000276 protein binding site [polypeptide binding]; other site 742729000277 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 742729000278 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 742729000279 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 742729000280 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 742729000281 heat shock protein HtpX; Provisional; Region: PRK03072 742729000282 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 742729000283 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 742729000284 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729000285 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729000286 putative substrate translocation pore; other site 742729000287 RelB antitoxin; Region: RelB; cl01171 742729000288 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 742729000289 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 742729000290 DNA binding site [nucleotide binding] 742729000291 active site 742729000292 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 742729000293 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 742729000294 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 742729000295 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 742729000296 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 742729000297 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 742729000298 active site 742729000299 catalytic tetrad [active] 742729000300 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 742729000301 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 742729000302 FAD binding pocket [chemical binding]; other site 742729000303 conserved FAD binding motif [chemical binding]; other site 742729000304 phosphate binding motif [ion binding]; other site 742729000305 beta-alpha-beta structure motif; other site 742729000306 NAD binding pocket [chemical binding]; other site 742729000307 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 742729000308 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 742729000309 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 742729000310 DNA binding residues [nucleotide binding] 742729000311 putative dimer interface [polypeptide binding]; other site 742729000312 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 742729000313 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 742729000314 NADH(P)-binding; Region: NAD_binding_10; pfam13460 742729000315 NAD(P) binding site [chemical binding]; other site 742729000316 putative active site [active] 742729000317 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 742729000318 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 742729000319 catalytic Zn binding site [ion binding]; other site 742729000320 NAD(P) binding site [chemical binding]; other site 742729000321 structural Zn binding site [ion binding]; other site 742729000322 Transcriptional regulator [Transcription]; Region: LysR; COG0583 742729000323 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 742729000324 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 742729000325 dimerization interface [polypeptide binding]; other site 742729000326 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 742729000327 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 742729000328 NodB motif; other site 742729000329 active site 742729000330 catalytic site [active] 742729000331 metal binding site [ion binding]; metal-binding site 742729000332 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 742729000333 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 742729000334 active site 742729000335 intersubunit interface [polypeptide binding]; other site 742729000336 zinc binding site [ion binding]; other site 742729000337 Na+ binding site [ion binding]; other site 742729000338 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 742729000339 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 742729000340 GDP-binding site [chemical binding]; other site 742729000341 ACT binding site; other site 742729000342 IMP binding site; other site 742729000343 CrcB-like protein; Region: CRCB; pfam02537 742729000344 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 742729000345 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 742729000346 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 742729000347 TM-ABC transporter signature motif; other site 742729000348 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 742729000349 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 742729000350 TM-ABC transporter signature motif; other site 742729000351 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 742729000352 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 742729000353 Walker A/P-loop; other site 742729000354 ATP binding site [chemical binding]; other site 742729000355 Q-loop/lid; other site 742729000356 ABC transporter signature motif; other site 742729000357 Walker B; other site 742729000358 D-loop; other site 742729000359 H-loop/switch region; other site 742729000360 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 742729000361 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 742729000362 Walker A/P-loop; other site 742729000363 ATP binding site [chemical binding]; other site 742729000364 Q-loop/lid; other site 742729000365 ABC transporter signature motif; other site 742729000366 Walker B; other site 742729000367 D-loop; other site 742729000368 H-loop/switch region; other site 742729000369 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 742729000370 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 742729000371 ligand binding site [chemical binding]; other site 742729000372 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729000373 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729000374 DNA binding site [nucleotide binding] 742729000375 domain linker motif; other site 742729000376 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 742729000377 sucrose phosphorylase; Provisional; Region: PRK13840 742729000378 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 742729000379 active site 742729000380 homodimer interface [polypeptide binding]; other site 742729000381 catalytic site [active] 742729000382 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 742729000383 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729000384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729000385 putative substrate translocation pore; other site 742729000386 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 742729000387 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 742729000388 ligand binding site [chemical binding]; other site 742729000389 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 742729000390 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 742729000391 ATP-grasp domain; Region: ATP-grasp_4; cl17255 742729000392 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 742729000393 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 742729000394 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 742729000395 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 742729000396 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 742729000397 metabolite-proton symporter; Region: 2A0106; TIGR00883 742729000398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729000399 putative substrate translocation pore; other site 742729000400 ketol-acid reductoisomerase; Provisional; Region: PRK05479 742729000401 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 742729000402 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 742729000403 Domain of unknown function (DUF303); Region: DUF303; pfam03629 742729000404 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 742729000405 active site 742729000406 catalytic triad [active] 742729000407 oxyanion hole [active] 742729000408 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 742729000409 beta-galactosidase; Region: BGL; TIGR03356 742729000410 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729000411 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729000412 DNA binding site [nucleotide binding] 742729000413 domain linker motif; other site 742729000414 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 742729000415 ligand binding site [chemical binding]; other site 742729000416 dimerization interface [polypeptide binding]; other site 742729000417 Protein of unknown function, DUF624; Region: DUF624; pfam04854 742729000418 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 742729000419 putative active cleft [active] 742729000420 dimerization interface [polypeptide binding]; other site 742729000421 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 742729000422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000423 Walker A/P-loop; other site 742729000424 ATP binding site [chemical binding]; other site 742729000425 Q-loop/lid; other site 742729000426 ABC transporter signature motif; other site 742729000427 Walker B; other site 742729000428 D-loop; other site 742729000429 H-loop/switch region; other site 742729000430 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 742729000431 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 742729000432 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 742729000433 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 742729000434 Walker A/P-loop; other site 742729000435 ATP binding site [chemical binding]; other site 742729000436 Q-loop/lid; other site 742729000437 ABC transporter signature motif; other site 742729000438 Walker B; other site 742729000439 D-loop; other site 742729000440 H-loop/switch region; other site 742729000441 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 742729000442 FtsX-like permease family; Region: FtsX; pfam02687 742729000443 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 742729000444 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 742729000445 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 742729000446 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 742729000447 FtsX-like permease family; Region: FtsX; pfam02687 742729000448 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000449 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 742729000450 ABC transporter signature motif; other site 742729000451 Walker B; other site 742729000452 D-loop; other site 742729000453 H-loop/switch region; other site 742729000454 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 742729000455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 742729000456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 742729000457 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000458 Walker A/P-loop; other site 742729000459 ATP binding site [chemical binding]; other site 742729000460 Q-loop/lid; other site 742729000461 ABC transporter signature motif; other site 742729000462 Walker B; other site 742729000463 D-loop; other site 742729000464 H-loop/switch region; other site 742729000465 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 742729000466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 742729000467 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 742729000468 Walker A/P-loop; other site 742729000469 ATP binding site [chemical binding]; other site 742729000470 Q-loop/lid; other site 742729000471 ABC transporter signature motif; other site 742729000472 Walker B; other site 742729000473 D-loop; other site 742729000474 H-loop/switch region; other site 742729000475 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 742729000476 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 742729000477 NodB motif; other site 742729000478 active site 742729000479 catalytic site [active] 742729000480 metal binding site [ion binding]; metal-binding site 742729000481 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 742729000482 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 742729000483 active site 742729000484 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 742729000485 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 742729000486 active site 742729000487 substrate binding site [chemical binding]; other site 742729000488 trimer interface [polypeptide binding]; other site 742729000489 CoA binding site [chemical binding]; other site 742729000490 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 742729000491 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 742729000492 ligand binding site [chemical binding]; other site 742729000493 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 742729000494 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 742729000495 Predicted membrane protein [Function unknown]; Region: COG1511 742729000496 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 742729000497 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 742729000498 Predicted membrane protein [Function unknown]; Region: COG1511 742729000499 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 742729000500 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 742729000501 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 742729000502 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 742729000503 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 742729000504 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 742729000505 Walker A/P-loop; other site 742729000506 ATP binding site [chemical binding]; other site 742729000507 Q-loop/lid; other site 742729000508 ABC transporter signature motif; other site 742729000509 Walker B; other site 742729000510 D-loop; other site 742729000511 H-loop/switch region; other site 742729000512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729000513 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 742729000514 Walker A/P-loop; other site 742729000515 ATP binding site [chemical binding]; other site 742729000516 Q-loop/lid; other site 742729000517 ABC transporter signature motif; other site 742729000518 Walker B; other site 742729000519 D-loop; other site 742729000520 H-loop/switch region; other site 742729000521 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 742729000522 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 742729000523 intersubunit interface [polypeptide binding]; other site 742729000524 YodA lipocalin-like domain; Region: YodA; cl01365 742729000525 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 742729000526 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 742729000527 active site 742729000528 nucleophile elbow; other site 742729000529 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 742729000530 Peptidase family C69; Region: Peptidase_C69; pfam03577 742729000531 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 742729000532 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 742729000533 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 742729000534 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 742729000535 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 742729000536 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 742729000537 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 742729000538 Nitrogen regulatory protein P-II; Region: P-II; smart00938 742729000539 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 742729000540 metal binding triad; other site 742729000541 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 742729000542 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 742729000543 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 742729000544 sequence-specific DNA binding site [nucleotide binding]; other site 742729000545 salt bridge; other site 742729000546 replicative DNA helicase; Region: DnaB; TIGR00665 742729000547 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 742729000548 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 742729000549 Walker A motif; other site 742729000550 ATP binding site [chemical binding]; other site 742729000551 Walker B motif; other site 742729000552 DNA binding loops [nucleotide binding] 742729000553 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 742729000554 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 742729000555 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 742729000556 catalytic triad [active] 742729000557 Uncharacterized conserved protein [Function unknown]; Region: COG3937 742729000558 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 742729000559 ABC1 family; Region: ABC1; cl17513 742729000560 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 742729000561 active site 742729000562 catalytic site [active] 742729000563 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 742729000564 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 742729000565 active site 742729000566 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 742729000567 active site 742729000568 Ap6A binding site [chemical binding]; other site 742729000569 nudix motif; other site 742729000570 metal binding site [ion binding]; metal-binding site 742729000571 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 742729000572 catalytic core [active] 742729000573 polyphosphate kinase; Provisional; Region: PRK05443 742729000574 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 742729000575 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 742729000576 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 742729000577 putative domain interface [polypeptide binding]; other site 742729000578 putative active site [active] 742729000579 catalytic site [active] 742729000580 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 742729000581 putative domain interface [polypeptide binding]; other site 742729000582 putative active site [active] 742729000583 catalytic site [active] 742729000584 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 742729000585 Type II/IV secretion system protein; Region: T2SE; pfam00437 742729000586 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 742729000587 Walker B motif; other site 742729000588 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 742729000589 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 742729000590 TadE-like protein; Region: TadE; pfam07811 742729000591 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 742729000592 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729000593 Walker A motif; other site 742729000594 ATP binding site [chemical binding]; other site 742729000595 Walker B motif; other site 742729000596 arginine finger; other site 742729000597 recombination protein RecR; Reviewed; Region: recR; PRK00076 742729000598 RecR protein; Region: RecR; pfam02132 742729000599 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 742729000600 putative active site [active] 742729000601 putative metal-binding site [ion binding]; other site 742729000602 tetramer interface [polypeptide binding]; other site 742729000603 aspartate kinase; Reviewed; Region: PRK06635 742729000604 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 742729000605 putative nucleotide binding site [chemical binding]; other site 742729000606 putative catalytic residues [active] 742729000607 putative Mg ion binding site [ion binding]; other site 742729000608 putative aspartate binding site [chemical binding]; other site 742729000609 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 742729000610 putative allosteric regulatory site; other site 742729000611 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 742729000612 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 742729000613 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 742729000614 2-isopropylmalate synthase; Validated; Region: PRK03739 742729000615 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 742729000616 active site 742729000617 catalytic residues [active] 742729000618 metal binding site [ion binding]; metal-binding site 742729000619 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 742729000620 Transglycosylase; Region: Transgly; pfam00912 742729000621 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 742729000622 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 742729000623 PAP2 superfamily; Region: PAP2; pfam01569 742729000624 active site 742729000625 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 742729000626 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 742729000627 active site 742729000628 interdomain interaction site; other site 742729000629 putative metal-binding site [ion binding]; other site 742729000630 nucleotide binding site [chemical binding]; other site 742729000631 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 742729000632 domain I; other site 742729000633 phosphate binding site [ion binding]; other site 742729000634 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 742729000635 domain II; other site 742729000636 domain III; other site 742729000637 nucleotide binding site [chemical binding]; other site 742729000638 DNA binding groove [nucleotide binding] 742729000639 catalytic site [active] 742729000640 domain IV; other site 742729000641 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 742729000642 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 742729000643 thymidylate kinase; Validated; Region: tmk; PRK00698 742729000644 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 742729000645 TMP-binding site; other site 742729000646 ATP-binding site [chemical binding]; other site 742729000647 DNA polymerase III subunit delta'; Validated; Region: PRK07940 742729000648 DNA polymerase III subunit delta'; Validated; Region: PRK08485 742729000649 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 742729000650 substrate binding site [chemical binding]; other site 742729000651 Peptidase family C69; Region: Peptidase_C69; pfam03577 742729000652 Peptidase family C69; Region: Peptidase_C69; pfam03577 742729000653 AAA domain; Region: AAA_14; pfam13173 742729000654 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 742729000655 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 742729000656 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 742729000657 Predicted membrane protein [Function unknown]; Region: COG2246 742729000658 GtrA-like protein; Region: GtrA; pfam04138 742729000659 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 742729000660 catalytic core [active] 742729000661 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729000662 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729000663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 742729000664 Transposase; Region: DDE_Tnp_ISL3; pfam01610 742729000665 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 742729000666 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 742729000667 active site 742729000668 HIGH motif; other site 742729000669 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 742729000670 active site 742729000671 KMSKS motif; other site 742729000672 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 742729000673 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 742729000674 putative active site [active] 742729000675 putative metal binding site [ion binding]; other site 742729000676 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 742729000677 Transcriptional regulator [Transcription]; Region: IclR; COG1414 742729000678 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 742729000679 Bacterial transcriptional regulator; Region: IclR; pfam01614 742729000680 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 742729000681 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 742729000682 substrate binding site [chemical binding]; other site 742729000683 ligand binding site [chemical binding]; other site 742729000684 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 742729000685 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 742729000686 substrate binding site [chemical binding]; other site 742729000687 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 742729000688 AsnC family; Region: AsnC_trans_reg; pfam01037 742729000689 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 742729000690 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 742729000691 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 742729000692 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 742729000693 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 742729000694 hinge; other site 742729000695 active site 742729000696 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 742729000697 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 742729000698 putative acyl-acceptor binding pocket; other site 742729000699 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 742729000700 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 742729000701 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 742729000702 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 742729000703 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 742729000704 ATP-grasp domain; Region: ATP-grasp_4; cl17255 742729000705 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 742729000706 CAAX protease self-immunity; Region: Abi; pfam02517 742729000707 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 742729000708 Mechanosensitive ion channel; Region: MS_channel; pfam00924 742729000709 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 742729000710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 742729000711 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 742729000712 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 742729000713 nucleophilic elbow; other site 742729000714 catalytic triad; other site 742729000715 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 742729000716 Predicted membrane protein [Function unknown]; Region: COG4905 742729000717 aspartate aminotransferase; Provisional; Region: PRK06836 742729000718 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729000719 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729000720 homodimer interface [polypeptide binding]; other site 742729000721 catalytic residue [active] 742729000722 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 742729000723 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 742729000724 binding surface 742729000725 TPR motif; other site 742729000726 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 742729000727 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 742729000728 substrate binding site [chemical binding]; other site 742729000729 ATP binding site [chemical binding]; other site 742729000730 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 742729000731 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 742729000732 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 742729000733 ssDNA binding site; other site 742729000734 generic binding surface II; other site 742729000735 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 742729000736 ATP binding site [chemical binding]; other site 742729000737 putative Mg++ binding site [ion binding]; other site 742729000738 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729000739 nucleotide binding region [chemical binding]; other site 742729000740 ATP-binding site [chemical binding]; other site 742729000741 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 742729000742 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 742729000743 S-adenosylmethionine binding site [chemical binding]; other site 742729000744 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 742729000745 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 742729000746 RimM N-terminal domain; Region: RimM; pfam01782 742729000747 PRC-barrel domain; Region: PRC; pfam05239 742729000748 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 742729000749 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 742729000750 G-X-X-G motif; other site 742729000751 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 742729000752 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 742729000753 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 742729000754 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 742729000755 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 742729000756 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 742729000757 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 742729000758 putative catalytic site [active] 742729000759 putative metal binding site [ion binding]; other site 742729000760 putative phosphate binding site [ion binding]; other site 742729000761 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 742729000762 putative catalytic site [active] 742729000763 putative phosphate binding site [ion binding]; other site 742729000764 putative metal binding site [ion binding]; other site 742729000765 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 742729000766 Cation efflux family; Region: Cation_efflux; pfam01545 742729000767 signal recognition particle protein; Provisional; Region: PRK10867 742729000768 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 742729000769 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 742729000770 P loop; other site 742729000771 GTP binding site [chemical binding]; other site 742729000772 Signal peptide binding domain; Region: SRP_SPB; pfam02978 742729000773 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 742729000774 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 742729000775 active site 742729000776 HIGH motif; other site 742729000777 nucleotide binding site [chemical binding]; other site 742729000778 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 742729000779 KMSKS motif; other site 742729000780 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 742729000781 tRNA binding surface [nucleotide binding]; other site 742729000782 anticodon binding site; other site 742729000783 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 742729000784 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 742729000785 ABC transporter; Region: ABC_tran_2; pfam12848 742729000786 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 742729000787 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 742729000788 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 742729000789 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 742729000790 catalytic triad [active] 742729000791 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 742729000792 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 742729000793 putative valine binding site [chemical binding]; other site 742729000794 dimer interface [polypeptide binding]; other site 742729000795 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 742729000796 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 742729000797 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 742729000798 PYR/PP interface [polypeptide binding]; other site 742729000799 dimer interface [polypeptide binding]; other site 742729000800 TPP binding site [chemical binding]; other site 742729000801 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 742729000802 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 742729000803 TPP-binding site [chemical binding]; other site 742729000804 dimer interface [polypeptide binding]; other site 742729000805 ribonuclease III; Reviewed; Region: rnc; PRK00102 742729000806 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 742729000807 dimerization interface [polypeptide binding]; other site 742729000808 active site 742729000809 metal binding site [ion binding]; metal-binding site 742729000810 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 742729000811 dsRNA binding site [nucleotide binding]; other site 742729000812 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 742729000813 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 742729000814 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 742729000815 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 742729000816 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 742729000817 active site 742729000818 (T/H)XGH motif; other site 742729000819 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 742729000820 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 742729000821 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 742729000822 active site 742729000823 catalytic tetrad [active] 742729000824 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 742729000825 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 742729000826 active site 742729000827 Ribonuclease PH; Region: RNase_PH_bact; cd11362 742729000828 ribonuclease PH; Reviewed; Region: rph; PRK00173 742729000829 hexamer interface [polypeptide binding]; other site 742729000830 active site 742729000831 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 742729000832 active site 742729000833 dimerization interface [polypeptide binding]; other site 742729000834 FemAB family; Region: FemAB; pfam02388 742729000835 Membrane transport protein; Region: Mem_trans; cl09117 742729000836 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 742729000837 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 742729000838 Substrate binding site; other site 742729000839 Cupin domain; Region: Cupin_2; cl17218 742729000840 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 742729000841 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 742729000842 active site 742729000843 dimer interface [polypeptide binding]; other site 742729000844 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 742729000845 dimer interface [polypeptide binding]; other site 742729000846 active site 742729000847 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 742729000848 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 742729000849 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 742729000850 Catalytic site [active] 742729000851 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 742729000852 RNA/DNA hybrid binding site [nucleotide binding]; other site 742729000853 active site 742729000854 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 742729000855 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 742729000856 Walker A/P-loop; other site 742729000857 ATP binding site [chemical binding]; other site 742729000858 Q-loop/lid; other site 742729000859 ABC transporter signature motif; other site 742729000860 Walker B; other site 742729000861 D-loop; other site 742729000862 H-loop/switch region; other site 742729000863 FtsX-like permease family; Region: FtsX; pfam02687 742729000864 Predicted permeases [General function prediction only]; Region: COG0679 742729000865 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 742729000866 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 742729000867 metal binding site [ion binding]; metal-binding site 742729000868 putative dimer interface [polypeptide binding]; other site 742729000869 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 742729000870 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 742729000871 homodimer interface [polypeptide binding]; other site 742729000872 oligonucleotide binding site [chemical binding]; other site 742729000873 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 742729000874 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 742729000875 GTPase CgtA; Reviewed; Region: obgE; PRK12296 742729000876 GTP1/OBG; Region: GTP1_OBG; pfam01018 742729000877 Obg GTPase; Region: Obg; cd01898 742729000878 G1 box; other site 742729000879 GTP/Mg2+ binding site [chemical binding]; other site 742729000880 Switch I region; other site 742729000881 G2 box; other site 742729000882 G3 box; other site 742729000883 Switch II region; other site 742729000884 G4 box; other site 742729000885 G5 box; other site 742729000886 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 742729000887 gamma-glutamyl kinase; Provisional; Region: PRK05429 742729000888 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 742729000889 nucleotide binding site [chemical binding]; other site 742729000890 homotetrameric interface [polypeptide binding]; other site 742729000891 putative phosphate binding site [ion binding]; other site 742729000892 putative allosteric binding site; other site 742729000893 PUA domain; Region: PUA; pfam01472 742729000894 aspartate aminotransferase; Provisional; Region: PRK05764 742729000895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729000896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729000897 homodimer interface [polypeptide binding]; other site 742729000898 catalytic residue [active] 742729000899 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 742729000900 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 742729000901 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 742729000902 putative homodimer interface [polypeptide binding]; other site 742729000903 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 742729000904 heterodimer interface [polypeptide binding]; other site 742729000905 homodimer interface [polypeptide binding]; other site 742729000906 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 742729000907 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 742729000908 23S rRNA interface [nucleotide binding]; other site 742729000909 L7/L12 interface [polypeptide binding]; other site 742729000910 putative thiostrepton binding site; other site 742729000911 L25 interface [polypeptide binding]; other site 742729000912 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 742729000913 mRNA/rRNA interface [nucleotide binding]; other site 742729000914 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 742729000915 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 742729000916 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 742729000917 BioY family; Region: BioY; pfam02632 742729000918 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 742729000919 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 742729000920 ATP-grasp domain; Region: ATP-grasp_4; cl17255 742729000921 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 742729000922 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 742729000923 carboxyltransferase (CT) interaction site; other site 742729000924 biotinylation site [posttranslational modification]; other site 742729000925 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 742729000926 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 742729000927 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 742729000928 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 742729000929 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 742729000930 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 742729000931 FMN binding site [chemical binding]; other site 742729000932 substrate binding site [chemical binding]; other site 742729000933 putative catalytic residue [active] 742729000934 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 742729000935 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 742729000936 active site 2 [active] 742729000937 active site 1 [active] 742729000938 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 742729000939 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 742729000940 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 742729000941 putative NAD(P) binding site [chemical binding]; other site 742729000942 active site 742729000943 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 742729000944 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 742729000945 active site 742729000946 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 742729000947 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 742729000948 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 742729000949 NAD binding site [chemical binding]; other site 742729000950 dimer interface [polypeptide binding]; other site 742729000951 tetramer (dimer of dimers) interface [polypeptide binding]; other site 742729000952 substrate binding site [chemical binding]; other site 742729000953 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 742729000954 16S/18S rRNA binding site [nucleotide binding]; other site 742729000955 S13e-L30e interaction site [polypeptide binding]; other site 742729000956 25S rRNA binding site [nucleotide binding]; other site 742729000957 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 742729000958 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 742729000959 oligomer interface [polypeptide binding]; other site 742729000960 RNA binding site [nucleotide binding]; other site 742729000961 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 742729000962 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 742729000963 RNase E interface [polypeptide binding]; other site 742729000964 trimer interface [polypeptide binding]; other site 742729000965 active site 742729000966 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 742729000967 putative nucleic acid binding region [nucleotide binding]; other site 742729000968 G-X-X-G motif; other site 742729000969 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 742729000970 RNA binding site [nucleotide binding]; other site 742729000971 domain interface; other site 742729000972 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 742729000973 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 742729000974 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 742729000975 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 742729000976 dimer interface [polypeptide binding]; other site 742729000977 putative radical transfer pathway; other site 742729000978 diiron center [ion binding]; other site 742729000979 tyrosyl radical; other site 742729000980 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 742729000981 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 742729000982 Class I ribonucleotide reductase; Region: RNR_I; cd01679 742729000983 active site 742729000984 dimer interface [polypeptide binding]; other site 742729000985 catalytic residues [active] 742729000986 effector binding site; other site 742729000987 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 742729000988 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 742729000989 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 742729000990 catalytic residues [active] 742729000991 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 742729000992 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 742729000993 active site 742729000994 catalytic tetrad [active] 742729000995 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 742729000996 Peptidase family U32; Region: Peptidase_U32; pfam01136 742729000997 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 742729000998 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 742729000999 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 742729001000 substrate binding site; other site 742729001001 dimer interface; other site 742729001002 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 742729001003 putative substrate binding pocket [chemical binding]; other site 742729001004 AC domain interface; other site 742729001005 catalytic triad [active] 742729001006 AB domain interface; other site 742729001007 interchain disulfide; other site 742729001008 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 742729001009 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 742729001010 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 742729001011 trimer interface [polypeptide binding]; other site 742729001012 active site 742729001013 G bulge; other site 742729001014 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 742729001015 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 742729001016 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 742729001017 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 742729001018 catalytic triad [active] 742729001019 catalytic triad [active] 742729001020 oxyanion hole [active] 742729001021 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 742729001022 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 742729001023 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 742729001024 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 742729001025 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 742729001026 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 742729001027 dimer interface [polypeptide binding]; other site 742729001028 phosphorylation site [posttranslational modification] 742729001029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 742729001030 ATP binding site [chemical binding]; other site 742729001031 Mg2+ binding site [ion binding]; other site 742729001032 G-X-G motif; other site 742729001033 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 742729001034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 742729001035 active site 742729001036 phosphorylation site [posttranslational modification] 742729001037 intermolecular recognition site; other site 742729001038 dimerization interface [polypeptide binding]; other site 742729001039 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 742729001040 DNA binding site [nucleotide binding] 742729001041 PBP superfamily domain; Region: PBP_like_2; cl17296 742729001042 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 742729001043 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729001044 dimer interface [polypeptide binding]; other site 742729001045 conserved gate region; other site 742729001046 putative PBP binding loops; other site 742729001047 ABC-ATPase subunit interface; other site 742729001048 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 742729001049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729001050 dimer interface [polypeptide binding]; other site 742729001051 conserved gate region; other site 742729001052 putative PBP binding loops; other site 742729001053 ABC-ATPase subunit interface; other site 742729001054 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 742729001055 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 742729001056 Walker A/P-loop; other site 742729001057 ATP binding site [chemical binding]; other site 742729001058 Q-loop/lid; other site 742729001059 ABC transporter signature motif; other site 742729001060 Walker B; other site 742729001061 D-loop; other site 742729001062 H-loop/switch region; other site 742729001063 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 742729001064 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 742729001065 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 742729001066 intersubunit interface [polypeptide binding]; other site 742729001067 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 742729001068 23S rRNA interface [nucleotide binding]; other site 742729001069 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 742729001070 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 742729001071 peripheral dimer interface [polypeptide binding]; other site 742729001072 core dimer interface [polypeptide binding]; other site 742729001073 L10 interface [polypeptide binding]; other site 742729001074 L11 interface [polypeptide binding]; other site 742729001075 putative EF-Tu interaction site [polypeptide binding]; other site 742729001076 putative EF-G interaction site [polypeptide binding]; other site 742729001077 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 742729001078 phosphopeptide binding site; other site 742729001079 Part of AAA domain; Region: AAA_19; pfam13245 742729001080 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 742729001081 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 742729001082 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 742729001083 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 742729001084 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 742729001085 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 742729001086 Coenzyme A binding pocket [chemical binding]; other site 742729001087 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 742729001088 oligomerisation interface [polypeptide binding]; other site 742729001089 mobile loop; other site 742729001090 roof hairpin; other site 742729001091 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 742729001092 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 742729001093 FAD binding domain; Region: FAD_binding_4; pfam01565 742729001094 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 742729001095 amino acid transporter; Region: 2A0306; TIGR00909 742729001096 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 742729001097 Ferredoxin [Energy production and conversion]; Region: COG1146 742729001098 4Fe-4S binding domain; Region: Fer4; pfam00037 742729001099 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 742729001100 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729001101 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729001102 homodimer interface [polypeptide binding]; other site 742729001103 catalytic residue [active] 742729001104 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 742729001105 active site 742729001106 DNA polymerase IV; Validated; Region: PRK02406 742729001107 DNA binding site [nucleotide binding] 742729001108 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 742729001109 dimerization interface [polypeptide binding]; other site 742729001110 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 742729001111 NAD binding site [chemical binding]; other site 742729001112 ligand binding site [chemical binding]; other site 742729001113 catalytic site [active] 742729001114 Uncharacterized conserved protein [Function unknown]; Region: COG1739 742729001115 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 742729001116 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 742729001117 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 742729001118 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 742729001119 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 742729001120 23S rRNA interface [nucleotide binding]; other site 742729001121 L3 interface [polypeptide binding]; other site 742729001122 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 742729001123 pullulanase, type I; Region: pulA_typeI; TIGR02104 742729001124 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 742729001125 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 742729001126 active site 742729001127 catalytic site [active] 742729001128 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 742729001129 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 742729001130 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 742729001131 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 742729001132 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 742729001133 putative catalytic cysteine [active] 742729001134 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 742729001135 putative active site [active] 742729001136 metal binding site [ion binding]; metal-binding site 742729001137 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 742729001138 YwiC-like protein; Region: YwiC; pfam14256 742729001139 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 742729001140 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 742729001141 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 742729001142 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 742729001143 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 742729001144 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 742729001145 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 742729001146 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 742729001147 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 742729001148 protein-rRNA interface [nucleotide binding]; other site 742729001149 putative translocon binding site; other site 742729001150 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 742729001151 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 742729001152 G-X-X-G motif; other site 742729001153 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 742729001154 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 742729001155 23S rRNA interface [nucleotide binding]; other site 742729001156 5S rRNA interface [nucleotide binding]; other site 742729001157 putative antibiotic binding site [chemical binding]; other site 742729001158 L25 interface [polypeptide binding]; other site 742729001159 L27 interface [polypeptide binding]; other site 742729001160 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 742729001161 23S rRNA interface [nucleotide binding]; other site 742729001162 putative translocon interaction site; other site 742729001163 signal recognition particle (SRP54) interaction site; other site 742729001164 L23 interface [polypeptide binding]; other site 742729001165 trigger factor interaction site; other site 742729001166 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 742729001167 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 742729001168 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 742729001169 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 742729001170 RNA binding site [nucleotide binding]; other site 742729001171 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 742729001172 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 742729001173 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 742729001174 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 742729001175 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 742729001176 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 742729001177 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 742729001178 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 742729001179 23S rRNA interface [nucleotide binding]; other site 742729001180 L21e interface [polypeptide binding]; other site 742729001181 5S rRNA interface [nucleotide binding]; other site 742729001182 L27 interface [polypeptide binding]; other site 742729001183 L5 interface [polypeptide binding]; other site 742729001184 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 742729001185 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 742729001186 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 742729001187 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 742729001188 23S rRNA binding site [nucleotide binding]; other site 742729001189 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 742729001190 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 742729001191 SecY translocase; Region: SecY; pfam00344 742729001192 adenylate kinase; Reviewed; Region: adk; PRK00279 742729001193 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 742729001194 AMP-binding site [chemical binding]; other site 742729001195 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 742729001196 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 742729001197 rRNA binding site [nucleotide binding]; other site 742729001198 predicted 30S ribosome binding site; other site 742729001199 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 742729001200 30S ribosomal protein S13; Region: bact_S13; TIGR03631 742729001201 30S ribosomal protein S11; Validated; Region: PRK05309 742729001202 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 742729001203 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 742729001204 alphaNTD homodimer interface [polypeptide binding]; other site 742729001205 alphaNTD - beta interaction site [polypeptide binding]; other site 742729001206 alphaNTD - beta' interaction site [polypeptide binding]; other site 742729001207 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 742729001208 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 742729001209 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 742729001210 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 742729001211 dimerization interface 3.5A [polypeptide binding]; other site 742729001212 active site 742729001213 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 742729001214 NusA N-terminal domain; Region: NusA_N; pfam08529 742729001215 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 742729001216 RNA binding site [nucleotide binding]; other site 742729001217 homodimer interface [polypeptide binding]; other site 742729001218 NusA-like KH domain; Region: KH_5; pfam13184 742729001219 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 742729001220 G-X-X-G motif; other site 742729001221 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 742729001222 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 742729001223 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 742729001224 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 742729001225 G1 box; other site 742729001226 putative GEF interaction site [polypeptide binding]; other site 742729001227 GTP/Mg2+ binding site [chemical binding]; other site 742729001228 Switch I region; other site 742729001229 G2 box; other site 742729001230 G3 box; other site 742729001231 Switch II region; other site 742729001232 G4 box; other site 742729001233 G5 box; other site 742729001234 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 742729001235 Translation-initiation factor 2; Region: IF-2; pfam11987 742729001236 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 742729001237 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 742729001238 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 742729001239 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 742729001240 RNA binding site [nucleotide binding]; other site 742729001241 active site 742729001242 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 742729001243 FAD synthetase; Region: FAD_syn; pfam06574 742729001244 active site 742729001245 nucleotide binding site [chemical binding]; other site 742729001246 HIGH motif; other site 742729001247 KMSKS motif; other site 742729001248 Riboflavin kinase; Region: Flavokinase; smart00904 742729001249 DNA repair protein RadA; Provisional; Region: PRK11823 742729001250 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 742729001251 Walker A motif; other site 742729001252 ATP binding site [chemical binding]; other site 742729001253 Walker B motif; other site 742729001254 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 742729001255 ADP-ribosylation factor GTPase-activating protein AGD10; Provisional; Region: PLN03114 742729001256 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 742729001257 tetramer (dimer of dimers) interface [polypeptide binding]; other site 742729001258 active site 742729001259 dimer interface [polypeptide binding]; other site 742729001260 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 742729001261 RNA/DNA hybrid binding site [nucleotide binding]; other site 742729001262 active site 742729001263 seryl-tRNA synthetase; Provisional; Region: PRK05431 742729001264 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 742729001265 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 742729001266 dimer interface [polypeptide binding]; other site 742729001267 active site 742729001268 motif 1; other site 742729001269 motif 2; other site 742729001270 motif 3; other site 742729001271 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 742729001272 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 742729001273 phosphoglucomutase; Validated; Region: PRK07564 742729001274 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 742729001275 active site 742729001276 substrate binding site [chemical binding]; other site 742729001277 metal binding site [ion binding]; metal-binding site 742729001278 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 742729001279 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 742729001280 Tetratricopeptide repeat; Region: TPR_12; pfam13424 742729001281 Tetratricopeptide repeat; Region: TPR_12; pfam13424 742729001282 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 742729001283 binding surface 742729001284 TPR motif; other site 742729001285 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 742729001286 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 742729001287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 742729001288 active site 742729001289 phosphorylation site [posttranslational modification] 742729001290 intermolecular recognition site; other site 742729001291 dimerization interface [polypeptide binding]; other site 742729001292 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 742729001293 DNA binding residues [nucleotide binding] 742729001294 dimerization interface [polypeptide binding]; other site 742729001295 PspC domain; Region: PspC; pfam04024 742729001296 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 742729001297 PspC domain; Region: PspC; pfam04024 742729001298 IncA protein; Region: IncA; pfam04156 742729001299 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 742729001300 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 742729001301 homodimer interface [polypeptide binding]; other site 742729001302 substrate-cofactor binding pocket; other site 742729001303 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729001304 catalytic residue [active] 742729001305 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 742729001306 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 742729001307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 742729001308 catalytic residue [active] 742729001309 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 742729001310 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 742729001311 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 742729001312 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 742729001313 dimer interface [polypeptide binding]; other site 742729001314 putative anticodon binding site; other site 742729001315 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 742729001316 motif 1; other site 742729001317 dimer interface [polypeptide binding]; other site 742729001318 active site 742729001319 motif 2; other site 742729001320 motif 3; other site 742729001321 Phospholipase B; Region: Phospholip_B; pfam04916 742729001322 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 742729001323 trimer interface [polypeptide binding]; other site 742729001324 active site 742729001325 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 742729001326 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 742729001327 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 742729001328 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 742729001329 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 742729001330 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 742729001331 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 742729001332 UbiA prenyltransferase family; Region: UbiA; pfam01040 742729001333 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 742729001334 catalytic core [active] 742729001335 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 742729001336 myosin-cross-reactive antigen; Provisional; Region: PRK13977 742729001337 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 742729001338 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 742729001339 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 742729001340 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 742729001341 NAD(P) binding site [chemical binding]; other site 742729001342 mannose-6-phosphate isomerase; Region: PLN02288 742729001343 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 742729001344 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 742729001345 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 742729001346 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 742729001347 ATP binding site [chemical binding]; other site 742729001348 Mg2+ binding site [ion binding]; other site 742729001349 G-X-G motif; other site 742729001350 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 742729001351 PhoU domain; Region: PhoU; pfam01895 742729001352 PhoU domain; Region: PhoU; pfam01895 742729001353 phosphoserine aminotransferase; Provisional; Region: PRK03080 742729001354 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 742729001355 catalytic residue [active] 742729001356 CHAP domain; Region: CHAP; pfam05257 742729001357 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 742729001358 NlpC/P60 family; Region: NLPC_P60; cl17555 742729001359 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 742729001360 Ligand Binding Site [chemical binding]; other site 742729001361 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 742729001362 Ligand Binding Site [chemical binding]; other site 742729001363 OsmC-like protein; Region: OsmC; cl00767 742729001364 thymidylate synthase; Reviewed; Region: thyA; PRK01827 742729001365 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 742729001366 dimerization interface [polypeptide binding]; other site 742729001367 active site 742729001368 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 742729001369 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 742729001370 folate binding site [chemical binding]; other site 742729001371 NADP+ binding site [chemical binding]; other site 742729001372 Low molecular weight phosphatase family; Region: LMWPc; cd00115 742729001373 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 742729001374 active site 742729001375 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 742729001376 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 742729001377 NAD(P) binding site [chemical binding]; other site 742729001378 active site 742729001379 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 742729001380 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 742729001381 putative active site [active] 742729001382 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 742729001383 serine/threonine protein kinase; Provisional; Region: PRK14879 742729001384 AAA domain; Region: AAA_21; pfam13304 742729001385 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 742729001386 putative active site [active] 742729001387 putative metal-binding site [ion binding]; other site 742729001388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 742729001389 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 742729001390 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 742729001391 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 742729001392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 742729001393 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 742729001394 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 742729001395 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 742729001396 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 742729001397 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 742729001398 Uncharacterized conserved protein [Function unknown]; Region: COG3189 742729001399 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 742729001400 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 742729001401 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 742729001402 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 742729001403 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 742729001404 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 742729001405 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 742729001406 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729001407 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729001408 DNA binding site [nucleotide binding] 742729001409 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 742729001410 putative dimerization interface [polypeptide binding]; other site 742729001411 putative ligand binding site [chemical binding]; other site 742729001412 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 742729001413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729001414 motif II; other site 742729001415 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 742729001416 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 742729001417 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 742729001418 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 742729001419 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 742729001420 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 742729001421 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 742729001422 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 742729001423 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 742729001424 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729001425 dimer interface [polypeptide binding]; other site 742729001426 conserved gate region; other site 742729001427 putative PBP binding loops; other site 742729001428 ABC-ATPase subunit interface; other site 742729001429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729001430 dimer interface [polypeptide binding]; other site 742729001431 conserved gate region; other site 742729001432 putative PBP binding loops; other site 742729001433 ABC-ATPase subunit interface; other site 742729001434 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729001435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729001436 DNA binding site [nucleotide binding] 742729001437 domain linker motif; other site 742729001438 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 742729001439 ligand binding site [chemical binding]; other site 742729001440 dimerization interface (open form) [polypeptide binding]; other site 742729001441 dimerization interface (closed form) [polypeptide binding]; other site 742729001442 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 742729001443 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 742729001444 active site 742729001445 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 742729001446 Domain of unknown function DUF20; Region: UPF0118; pfam01594 742729001447 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 742729001448 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 742729001449 DXD motif; other site 742729001450 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 742729001451 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 742729001452 Walker A/P-loop; other site 742729001453 ATP binding site [chemical binding]; other site 742729001454 Q-loop/lid; other site 742729001455 ABC transporter signature motif; other site 742729001456 Walker B; other site 742729001457 D-loop; other site 742729001458 H-loop/switch region; other site 742729001459 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 742729001460 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 742729001461 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 742729001462 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 742729001463 Ligand Binding Site [chemical binding]; other site 742729001464 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 742729001465 active site 742729001466 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 742729001467 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729001468 Walker A motif; other site 742729001469 ATP binding site [chemical binding]; other site 742729001470 Walker B motif; other site 742729001471 arginine finger; other site 742729001472 Peptidase family M41; Region: Peptidase_M41; pfam01434 742729001473 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 742729001474 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 742729001475 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 742729001476 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 742729001477 active site 742729001478 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 742729001479 catalytic triad [active] 742729001480 dimer interface [polypeptide binding]; other site 742729001481 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 742729001482 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 742729001483 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 742729001484 ABC transporter; Region: ABC_tran_2; pfam12848 742729001485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 742729001486 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 742729001487 active site 742729001488 catalytic residues [active] 742729001489 metal binding site [ion binding]; metal-binding site 742729001490 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 742729001491 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 742729001492 homodimer interface [polypeptide binding]; other site 742729001493 substrate-cofactor binding pocket; other site 742729001494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729001495 catalytic residue [active] 742729001496 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 742729001497 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 742729001498 xylose isomerase; Provisional; Region: PRK05474 742729001499 xylose isomerase; Region: xylose_isom_A; TIGR02630 742729001500 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 742729001501 active site 742729001502 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729001503 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729001504 DNA binding site [nucleotide binding] 742729001505 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 742729001506 putative ligand binding site [chemical binding]; other site 742729001507 putative dimerization interface [polypeptide binding]; other site 742729001508 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 742729001509 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 742729001510 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 742729001511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729001512 dimer interface [polypeptide binding]; other site 742729001513 conserved gate region; other site 742729001514 putative PBP binding loops; other site 742729001515 ABC-ATPase subunit interface; other site 742729001516 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 742729001517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729001518 dimer interface [polypeptide binding]; other site 742729001519 conserved gate region; other site 742729001520 putative PBP binding loops; other site 742729001521 ABC-ATPase subunit interface; other site 742729001522 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 742729001523 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 742729001524 inhibitor binding site; inhibition site 742729001525 active site 742729001526 Domain of unknown function (DUF303); Region: DUF303; pfam03629 742729001527 Domain of unknown function (DUF303); Region: DUF303; pfam03629 742729001528 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 742729001529 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 742729001530 substrate binding pocket [chemical binding]; other site 742729001531 catalytic triad [active] 742729001532 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 742729001533 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 742729001534 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 742729001535 active site 742729001536 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 742729001537 D-xylulose kinase; Region: XylB; TIGR01312 742729001538 nucleotide binding site [chemical binding]; other site 742729001539 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 742729001540 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 742729001541 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 742729001542 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 742729001543 peptide chain release factor 1; Validated; Region: prfA; PRK00591 742729001544 PCRF domain; Region: PCRF; pfam03462 742729001545 RF-1 domain; Region: RF-1; pfam00472 742729001546 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 742729001547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 742729001548 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 742729001549 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 742729001550 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 742729001551 Mg++ binding site [ion binding]; other site 742729001552 putative catalytic motif [active] 742729001553 substrate binding site [chemical binding]; other site 742729001554 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 742729001555 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 742729001556 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 742729001557 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 742729001558 active site 742729001559 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 742729001560 catalytic site [active] 742729001561 putative active site [active] 742729001562 putative substrate binding site [chemical binding]; other site 742729001563 dimer interface [polypeptide binding]; other site 742729001564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729001565 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 742729001566 active site 742729001567 motif I; other site 742729001568 motif II; other site 742729001569 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 742729001570 AAA domain; Region: AAA_30; pfam13604 742729001571 PIF1-like helicase; Region: PIF1; pfam05970 742729001572 prolyl-tRNA synthetase; Provisional; Region: PRK09194 742729001573 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 742729001574 dimer interface [polypeptide binding]; other site 742729001575 motif 1; other site 742729001576 active site 742729001577 motif 2; other site 742729001578 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 742729001579 putative deacylase active site [active] 742729001580 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 742729001581 active site 742729001582 motif 3; other site 742729001583 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 742729001584 anticodon binding site; other site 742729001585 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 742729001586 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 742729001587 dimer interface [polypeptide binding]; other site 742729001588 ssDNA binding site [nucleotide binding]; other site 742729001589 tetramer (dimer of dimers) interface [polypeptide binding]; other site 742729001590 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 742729001591 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 742729001592 active site 742729001593 Zn binding site [ion binding]; other site 742729001594 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 742729001595 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 742729001596 active site 742729001597 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 742729001598 Citrate synthase; Region: Citrate_synt; pfam00285 742729001599 oxalacetate binding site [chemical binding]; other site 742729001600 citrylCoA binding site [chemical binding]; other site 742729001601 coenzyme A binding site [chemical binding]; other site 742729001602 catalytic triad [active] 742729001603 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 742729001604 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 742729001605 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 742729001606 putative trimer interface [polypeptide binding]; other site 742729001607 putative CoA binding site [chemical binding]; other site 742729001608 peptide chain release factor 2; Validated; Region: prfB; PRK00578 742729001609 This domain is found in peptide chain release factors; Region: PCRF; smart00937 742729001610 RF-1 domain; Region: RF-1; pfam00472 742729001611 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 742729001612 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729001613 Walker A/P-loop; other site 742729001614 ATP binding site [chemical binding]; other site 742729001615 Q-loop/lid; other site 742729001616 ABC transporter signature motif; other site 742729001617 Walker B; other site 742729001618 D-loop; other site 742729001619 H-loop/switch region; other site 742729001620 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 742729001621 FtsX-like permease family; Region: FtsX; pfam02687 742729001622 Surface antigen [General function prediction only]; Region: COG3942 742729001623 CHAP domain; Region: CHAP; pfam05257 742729001624 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 742729001625 SmpB-tmRNA interface; other site 742729001626 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 742729001627 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 742729001628 substrate binding pocket [chemical binding]; other site 742729001629 membrane-bound complex binding site; other site 742729001630 hinge residues; other site 742729001631 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 742729001632 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 742729001633 substrate binding pocket [chemical binding]; other site 742729001634 membrane-bound complex binding site; other site 742729001635 hinge residues; other site 742729001636 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 742729001637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729001638 dimer interface [polypeptide binding]; other site 742729001639 conserved gate region; other site 742729001640 putative PBP binding loops; other site 742729001641 ABC-ATPase subunit interface; other site 742729001642 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 742729001643 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 742729001644 Walker A/P-loop; other site 742729001645 ATP binding site [chemical binding]; other site 742729001646 Q-loop/lid; other site 742729001647 ABC transporter signature motif; other site 742729001648 Walker B; other site 742729001649 D-loop; other site 742729001650 H-loop/switch region; other site 742729001651 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 742729001652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 742729001653 active site 742729001654 phosphorylation site [posttranslational modification] 742729001655 intermolecular recognition site; other site 742729001656 dimerization interface [polypeptide binding]; other site 742729001657 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 742729001658 DNA binding residues [nucleotide binding] 742729001659 dimerization interface [polypeptide binding]; other site 742729001660 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 742729001661 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 742729001662 glutaminase active site [active] 742729001663 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 742729001664 dimer interface [polypeptide binding]; other site 742729001665 active site 742729001666 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 742729001667 dimer interface [polypeptide binding]; other site 742729001668 active site 742729001669 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 742729001670 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 742729001671 active site 742729001672 pantothenate kinase; Reviewed; Region: PRK13318 742729001673 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 742729001674 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 742729001675 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 742729001676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729001677 dimer interface [polypeptide binding]; other site 742729001678 conserved gate region; other site 742729001679 putative PBP binding loops; other site 742729001680 ABC-ATPase subunit interface; other site 742729001681 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 742729001682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729001683 dimer interface [polypeptide binding]; other site 742729001684 conserved gate region; other site 742729001685 putative PBP binding loops; other site 742729001686 ABC-ATPase subunit interface; other site 742729001687 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 742729001688 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 742729001689 Walker A/P-loop; other site 742729001690 ATP binding site [chemical binding]; other site 742729001691 Q-loop/lid; other site 742729001692 ABC transporter signature motif; other site 742729001693 Walker B; other site 742729001694 D-loop; other site 742729001695 H-loop/switch region; other site 742729001696 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 742729001697 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 742729001698 Walker A/P-loop; other site 742729001699 ATP binding site [chemical binding]; other site 742729001700 Q-loop/lid; other site 742729001701 ABC transporter signature motif; other site 742729001702 Walker B; other site 742729001703 D-loop; other site 742729001704 H-loop/switch region; other site 742729001705 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 742729001706 cystathionine gamma-synthase; Provisional; Region: PRK07811 742729001707 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 742729001708 homodimer interface [polypeptide binding]; other site 742729001709 substrate-cofactor binding pocket; other site 742729001710 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729001711 catalytic residue [active] 742729001712 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 742729001713 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 742729001714 dimer interface [polypeptide binding]; other site 742729001715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729001716 catalytic residue [active] 742729001717 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 742729001718 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 742729001719 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 742729001720 ATP binding site [chemical binding]; other site 742729001721 ATP binding site [chemical binding]; other site 742729001722 putative Mg++ binding site [ion binding]; other site 742729001723 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729001724 nucleotide binding region [chemical binding]; other site 742729001725 ATP-binding site [chemical binding]; other site 742729001726 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 742729001727 HRDC domain; Region: HRDC; pfam00570 742729001728 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 742729001729 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 742729001730 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 742729001731 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 742729001732 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 742729001733 active site 742729001734 8-oxo-dGMP binding site [chemical binding]; other site 742729001735 nudix motif; other site 742729001736 metal binding site [ion binding]; metal-binding site 742729001737 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 742729001738 PLD-like domain; Region: PLDc_2; pfam13091 742729001739 putative homodimer interface [polypeptide binding]; other site 742729001740 putative active site [active] 742729001741 catalytic site [active] 742729001742 DEAD-like helicases superfamily; Region: DEXDc; smart00487 742729001743 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 742729001744 ATP binding site [chemical binding]; other site 742729001745 putative Mg++ binding site [ion binding]; other site 742729001746 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729001747 nucleotide binding region [chemical binding]; other site 742729001748 ATP-binding site [chemical binding]; other site 742729001749 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 742729001750 Protein of unknown function DUF262; Region: DUF262; pfam03235 742729001751 Uncharacterized conserved protein [Function unknown]; Region: COG1479 742729001752 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 742729001753 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 742729001754 Fic/DOC family; Region: Fic; cl00960 742729001755 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 742729001756 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 742729001757 Coenzyme A binding pocket [chemical binding]; other site 742729001758 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 742729001759 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 742729001760 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 742729001761 putative active site [active] 742729001762 metal binding site [ion binding]; metal-binding site 742729001763 S-ribosylhomocysteinase; Provisional; Region: PRK02260 742729001764 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 742729001765 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 742729001766 alanine racemase; Reviewed; Region: alr; PRK00053 742729001767 active site 742729001768 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 742729001769 dimer interface [polypeptide binding]; other site 742729001770 substrate binding site [chemical binding]; other site 742729001771 catalytic residues [active] 742729001772 DNA primase; Validated; Region: dnaG; PRK05667 742729001773 CHC2 zinc finger; Region: zf-CHC2; pfam01807 742729001774 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 742729001775 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 742729001776 active site 742729001777 metal binding site [ion binding]; metal-binding site 742729001778 interdomain interaction site; other site 742729001779 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 742729001780 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 742729001781 transmembrane helices; other site 742729001782 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 742729001783 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 742729001784 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 742729001785 TPP-binding site; other site 742729001786 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 742729001787 PYR/PP interface [polypeptide binding]; other site 742729001788 dimer interface [polypeptide binding]; other site 742729001789 TPP binding site [chemical binding]; other site 742729001790 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 742729001791 AIR carboxylase; Region: AIRC; pfam00731 742729001792 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 742729001793 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 742729001794 NAD binding site [chemical binding]; other site 742729001795 ATP-grasp domain; Region: ATP-grasp; pfam02222 742729001796 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 742729001797 metal binding site 2 [ion binding]; metal-binding site 742729001798 putative DNA binding helix; other site 742729001799 metal binding site 1 [ion binding]; metal-binding site 742729001800 dimer interface [polypeptide binding]; other site 742729001801 structural Zn2+ binding site [ion binding]; other site 742729001802 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 742729001803 Putative esterase; Region: Esterase; pfam00756 742729001804 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 742729001805 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 742729001806 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 742729001807 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 742729001808 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 742729001809 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 742729001810 dimerization interface [polypeptide binding]; other site 742729001811 putative ATP binding site [chemical binding]; other site 742729001812 amidophosphoribosyltransferase; Provisional; Region: PRK07272 742729001813 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 742729001814 active site 742729001815 tetramer interface [polypeptide binding]; other site 742729001816 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 742729001817 active site 742729001818 Y-family of DNA polymerases; Region: PolY; cl12025 742729001819 DNA polymerase IV; Reviewed; Region: PRK03103 742729001820 active site 742729001821 DNA binding site [nucleotide binding] 742729001822 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 742729001823 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 742729001824 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 742729001825 Short C-terminal domain; Region: SHOCT; pfam09851 742729001826 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 742729001827 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 742729001828 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 742729001829 dimerization interface [polypeptide binding]; other site 742729001830 ATP binding site [chemical binding]; other site 742729001831 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 742729001832 dimerization interface [polypeptide binding]; other site 742729001833 ATP binding site [chemical binding]; other site 742729001834 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 742729001835 conserved cys residue [active] 742729001836 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 742729001837 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 742729001838 ATP binding site [chemical binding]; other site 742729001839 active site 742729001840 substrate binding site [chemical binding]; other site 742729001841 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 742729001842 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 742729001843 ATP-grasp domain; Region: ATP-grasp; pfam02222 742729001844 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 742729001845 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 742729001846 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 742729001847 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 742729001848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 742729001849 catalytic residue [active] 742729001850 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 742729001851 S17 interaction site [polypeptide binding]; other site 742729001852 S8 interaction site; other site 742729001853 16S rRNA interaction site [nucleotide binding]; other site 742729001854 streptomycin interaction site [chemical binding]; other site 742729001855 23S rRNA interaction site [nucleotide binding]; other site 742729001856 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 742729001857 30S ribosomal protein S7; Validated; Region: PRK05302 742729001858 elongation factor G; Reviewed; Region: PRK00007 742729001859 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 742729001860 G1 box; other site 742729001861 putative GEF interaction site [polypeptide binding]; other site 742729001862 GTP/Mg2+ binding site [chemical binding]; other site 742729001863 Switch I region; other site 742729001864 G2 box; other site 742729001865 G3 box; other site 742729001866 Switch II region; other site 742729001867 G4 box; other site 742729001868 G5 box; other site 742729001869 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 742729001870 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 742729001871 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 742729001872 elongation factor Tu; Reviewed; Region: PRK00049 742729001873 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 742729001874 G1 box; other site 742729001875 GEF interaction site [polypeptide binding]; other site 742729001876 GTP/Mg2+ binding site [chemical binding]; other site 742729001877 Switch I region; other site 742729001878 G2 box; other site 742729001879 G3 box; other site 742729001880 Switch II region; other site 742729001881 G4 box; other site 742729001882 G5 box; other site 742729001883 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 742729001884 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 742729001885 Antibiotic Binding Site [chemical binding]; other site 742729001886 Plant phosphoribosyltransferase C-terminal; Region: PRT_C; pfam08372 742729001887 elongation factor P; Validated; Region: PRK00529 742729001888 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 742729001889 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 742729001890 RNA binding site [nucleotide binding]; other site 742729001891 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 742729001892 RNA binding site [nucleotide binding]; other site 742729001893 transcription antitermination factor NusB; Region: nusB; TIGR01951 742729001894 putative RNA binding site [nucleotide binding]; other site 742729001895 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 742729001896 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 742729001897 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 742729001898 catalytic site [active] 742729001899 subunit interface [polypeptide binding]; other site 742729001900 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 742729001901 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 742729001902 ATP-grasp domain; Region: ATP-grasp_4; cl17255 742729001903 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 742729001904 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 742729001905 ATP-grasp domain; Region: ATP-grasp_4; cl17255 742729001906 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 742729001907 IMP binding site; other site 742729001908 dimer interface [polypeptide binding]; other site 742729001909 interdomain contacts; other site 742729001910 partial ornithine binding site; other site 742729001911 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 742729001912 active site 742729001913 dimer interface [polypeptide binding]; other site 742729001914 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 742729001915 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 742729001916 catalytic site [active] 742729001917 G-X2-G-X-G-K; other site 742729001918 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 742729001919 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 742729001920 S-adenosylmethionine synthetase; Validated; Region: PRK05250 742729001921 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 742729001922 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 742729001923 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 742729001924 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 742729001925 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 742729001926 S-adenosylmethionine binding site [chemical binding]; other site 742729001927 primosome assembly protein PriA; Provisional; Region: PRK14873 742729001928 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 742729001929 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 742729001930 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 742729001931 putative active site [active] 742729001932 substrate binding site [chemical binding]; other site 742729001933 putative cosubstrate binding site; other site 742729001934 catalytic site [active] 742729001935 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 742729001936 substrate binding site [chemical binding]; other site 742729001937 phosphoserine phosphatase SerB; Region: serB; TIGR00338 742729001938 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729001939 motif II; other site 742729001940 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 742729001941 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 742729001942 proteasome ATPase; Region: pup_AAA; TIGR03689 742729001943 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729001944 Walker A motif; other site 742729001945 ATP binding site [chemical binding]; other site 742729001946 Walker B motif; other site 742729001947 arginine finger; other site 742729001948 Pup-ligase protein; Region: Pup_ligase; cl15463 742729001949 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 742729001950 active site 742729001951 Pup-like protein; Region: Pup; cl05289 742729001952 Pup-ligase protein; Region: Pup_ligase; cl15463 742729001953 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 742729001954 IHF dimer interface [polypeptide binding]; other site 742729001955 IHF - DNA interface [nucleotide binding]; other site 742729001956 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 742729001957 adenylosuccinate lyase; Provisional; Region: PRK09285 742729001958 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 742729001959 tetramer interface [polypeptide binding]; other site 742729001960 active site 742729001961 Secretory lipase; Region: LIP; pfam03583 742729001962 von Willebrand factor type A domain; Region: VWA_2; pfam13519 742729001963 metal ion-dependent adhesion site (MIDAS); other site 742729001964 von Willebrand factor type A domain; Region: VWA_2; pfam13519 742729001965 metal ion-dependent adhesion site (MIDAS); other site 742729001966 Protein of unknown function DUF58; Region: DUF58; pfam01882 742729001967 MoxR-like ATPases [General function prediction only]; Region: COG0714 742729001968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 742729001969 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 742729001970 ligand binding site [chemical binding]; other site 742729001971 active site 742729001972 UGI interface [polypeptide binding]; other site 742729001973 catalytic site [active] 742729001974 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 742729001975 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 742729001976 DNA-binding site [nucleotide binding]; DNA binding site 742729001977 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 742729001978 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 742729001979 ring oligomerisation interface [polypeptide binding]; other site 742729001980 ATP/Mg binding site [chemical binding]; other site 742729001981 stacking interactions; other site 742729001982 hinge regions; other site 742729001983 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 742729001984 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 742729001985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 742729001986 active site 742729001987 phosphorylation site [posttranslational modification] 742729001988 intermolecular recognition site; other site 742729001989 dimerization interface [polypeptide binding]; other site 742729001990 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 742729001991 DNA binding site [nucleotide binding] 742729001992 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 742729001993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 742729001994 dimerization interface [polypeptide binding]; other site 742729001995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 742729001996 dimer interface [polypeptide binding]; other site 742729001997 phosphorylation site [posttranslational modification] 742729001998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 742729001999 ATP binding site [chemical binding]; other site 742729002000 Mg2+ binding site [ion binding]; other site 742729002001 G-X-G motif; other site 742729002002 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 742729002003 DNA-binding site [nucleotide binding]; DNA binding site 742729002004 RNA-binding motif; other site 742729002005 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 742729002006 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 742729002007 Ligand Binding Site [chemical binding]; other site 742729002008 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 742729002009 Ligand Binding Site [chemical binding]; other site 742729002010 Clp protease ATP binding subunit; Region: clpC; CHL00095 742729002011 Clp amino terminal domain; Region: Clp_N; pfam02861 742729002012 Clp amino terminal domain; Region: Clp_N; pfam02861 742729002013 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729002014 Walker A motif; other site 742729002015 ATP binding site [chemical binding]; other site 742729002016 Walker B motif; other site 742729002017 arginine finger; other site 742729002018 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729002019 Walker A motif; other site 742729002020 ATP binding site [chemical binding]; other site 742729002021 Walker B motif; other site 742729002022 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 742729002023 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 742729002024 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 742729002025 dimer interface [polypeptide binding]; other site 742729002026 anticodon binding site; other site 742729002027 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 742729002028 motif 1; other site 742729002029 dimer interface [polypeptide binding]; other site 742729002030 active site 742729002031 motif 2; other site 742729002032 GAD domain; Region: GAD; pfam02938 742729002033 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 742729002034 active site 742729002035 motif 3; other site 742729002036 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 742729002037 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 742729002038 dimer interface [polypeptide binding]; other site 742729002039 motif 1; other site 742729002040 active site 742729002041 motif 2; other site 742729002042 motif 3; other site 742729002043 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 742729002044 anticodon binding site; other site 742729002045 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 742729002046 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 742729002047 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 742729002048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 742729002049 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 742729002050 catalytic site [active] 742729002051 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 742729002052 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 742729002053 Walker A/P-loop; other site 742729002054 ATP binding site [chemical binding]; other site 742729002055 Q-loop/lid; other site 742729002056 ABC transporter signature motif; other site 742729002057 Walker B; other site 742729002058 D-loop; other site 742729002059 H-loop/switch region; other site 742729002060 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 742729002061 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 742729002062 substrate binding pocket [chemical binding]; other site 742729002063 membrane-bound complex binding site; other site 742729002064 hinge residues; other site 742729002065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729002066 dimer interface [polypeptide binding]; other site 742729002067 conserved gate region; other site 742729002068 ABC-ATPase subunit interface; other site 742729002069 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 742729002070 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729002071 dimer interface [polypeptide binding]; other site 742729002072 conserved gate region; other site 742729002073 putative PBP binding loops; other site 742729002074 ABC-ATPase subunit interface; other site 742729002075 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 742729002076 DEAD-like helicases superfamily; Region: DEXDc; smart00487 742729002077 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 742729002078 ATP binding site [chemical binding]; other site 742729002079 putative Mg++ binding site [ion binding]; other site 742729002080 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729002081 nucleotide binding region [chemical binding]; other site 742729002082 ATP-binding site [chemical binding]; other site 742729002083 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 742729002084 recombination factor protein RarA; Reviewed; Region: PRK13342 742729002085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729002086 Walker A motif; other site 742729002087 ATP binding site [chemical binding]; other site 742729002088 Walker B motif; other site 742729002089 arginine finger; other site 742729002090 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 742729002091 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729002092 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729002093 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 742729002094 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 742729002095 acyl-activating enzyme (AAE) consensus motif; other site 742729002096 putative AMP binding site [chemical binding]; other site 742729002097 putative active site [active] 742729002098 putative CoA binding site [chemical binding]; other site 742729002099 Transposase, Mutator family; Region: Transposase_mut; pfam00872 742729002100 MULE transposase domain; Region: MULE; pfam10551 742729002101 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 742729002102 Coenzyme A binding pocket [chemical binding]; other site 742729002103 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 742729002104 hypothetical protein; Provisional; Region: PRK11770 742729002105 Domain of unknown function (DUF307); Region: DUF307; pfam03733 742729002106 Domain of unknown function (DUF307); Region: DUF307; pfam03733 742729002107 Putative transcription activator [Transcription]; Region: TenA; COG0819 742729002108 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 742729002109 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 742729002110 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 742729002111 active site 742729002112 catalytic tetrad [active] 742729002113 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 742729002114 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 742729002115 Walker A/P-loop; other site 742729002116 ATP binding site [chemical binding]; other site 742729002117 Q-loop/lid; other site 742729002118 ABC transporter signature motif; other site 742729002119 Walker B; other site 742729002120 D-loop; other site 742729002121 H-loop/switch region; other site 742729002122 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 742729002123 Walker A/P-loop; other site 742729002124 ATP binding site [chemical binding]; other site 742729002125 Q-loop/lid; other site 742729002126 ABC transporter signature motif; other site 742729002127 Walker B; other site 742729002128 D-loop; other site 742729002129 H-loop/switch region; other site 742729002130 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 742729002131 Predicted membrane protein [Function unknown]; Region: COG3601 742729002132 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 742729002133 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 742729002134 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 742729002135 nucleotide binding site [chemical binding]; other site 742729002136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729002137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729002138 homodimer interface [polypeptide binding]; other site 742729002139 catalytic residue [active] 742729002140 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 742729002141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729002142 Walker A/P-loop; other site 742729002143 ATP binding site [chemical binding]; other site 742729002144 Q-loop/lid; other site 742729002145 ABC transporter signature motif; other site 742729002146 Walker B; other site 742729002147 D-loop; other site 742729002148 H-loop/switch region; other site 742729002149 Ligase N family; Region: LIGANc; smart00532 742729002150 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 742729002151 nucleotide binding pocket [chemical binding]; other site 742729002152 K-X-D-G motif; other site 742729002153 catalytic site [active] 742729002154 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 742729002155 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 742729002156 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 742729002157 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 742729002158 Dimer interface [polypeptide binding]; other site 742729002159 Domain of unknown function DUF59; Region: DUF59; cl00941 742729002160 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 742729002161 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 742729002162 glutamine synthetase, type I; Region: GlnA; TIGR00653 742729002163 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 742729002164 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 742729002165 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 742729002166 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 742729002167 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 742729002168 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 742729002169 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 742729002170 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 742729002171 hypothetical protein; Provisional; Region: PRK07907 742729002172 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 742729002173 active site 742729002174 metal binding site [ion binding]; metal-binding site 742729002175 dimer interface [polypeptide binding]; other site 742729002176 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 742729002177 Histidine kinase; Region: HisKA_3; pfam07730 742729002178 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 742729002179 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729002180 Q-loop/lid; other site 742729002181 ABC transporter signature motif; other site 742729002182 Walker B; other site 742729002183 D-loop; other site 742729002184 H-loop/switch region; other site 742729002185 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 742729002186 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 742729002187 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 742729002188 Walker A/P-loop; other site 742729002189 ATP binding site [chemical binding]; other site 742729002190 Q-loop/lid; other site 742729002191 ABC transporter signature motif; other site 742729002192 Walker B; other site 742729002193 D-loop; other site 742729002194 H-loop/switch region; other site 742729002195 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 742729002196 Walker A/P-loop; other site 742729002197 ATP binding site [chemical binding]; other site 742729002198 Q-loop/lid; other site 742729002199 ABC transporter signature motif; other site 742729002200 Walker B; other site 742729002201 D-loop; other site 742729002202 H-loop/switch region; other site 742729002203 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 742729002204 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 742729002205 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 742729002206 Walker A/P-loop; other site 742729002207 ATP binding site [chemical binding]; other site 742729002208 Q-loop/lid; other site 742729002209 ABC transporter signature motif; other site 742729002210 Walker B; other site 742729002211 D-loop; other site 742729002212 H-loop/switch region; other site 742729002213 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 742729002214 FtsX-like permease family; Region: FtsX; pfam02687 742729002215 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 742729002216 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 742729002217 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 742729002218 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 742729002219 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 742729002220 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 742729002221 dimer interface [polypeptide binding]; other site 742729002222 motif 1; other site 742729002223 active site 742729002224 motif 2; other site 742729002225 motif 3; other site 742729002226 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 742729002227 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 742729002228 putative tRNA-binding site [nucleotide binding]; other site 742729002229 B3/4 domain; Region: B3_4; pfam03483 742729002230 tRNA synthetase B5 domain; Region: B5; smart00874 742729002231 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 742729002232 dimer interface [polypeptide binding]; other site 742729002233 motif 1; other site 742729002234 motif 3; other site 742729002235 motif 2; other site 742729002236 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 742729002237 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 742729002238 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 742729002239 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 742729002240 heterotetramer interface [polypeptide binding]; other site 742729002241 active site pocket [active] 742729002242 cleavage site 742729002243 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 742729002244 feedback inhibition sensing region; other site 742729002245 homohexameric interface [polypeptide binding]; other site 742729002246 nucleotide binding site [chemical binding]; other site 742729002247 N-acetyl-L-glutamate binding site [chemical binding]; other site 742729002248 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 742729002249 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 742729002250 inhibitor-cofactor binding pocket; inhibition site 742729002251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729002252 catalytic residue [active] 742729002253 ornithine carbamoyltransferase; Provisional; Region: PRK00779 742729002254 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 742729002255 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 742729002256 arginine repressor; Provisional; Region: PRK03341 742729002257 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 742729002258 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 742729002259 argininosuccinate synthase; Provisional; Region: PRK13820 742729002260 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 742729002261 ANP binding site [chemical binding]; other site 742729002262 Substrate Binding Site II [chemical binding]; other site 742729002263 Substrate Binding Site I [chemical binding]; other site 742729002264 argininosuccinate lyase; Provisional; Region: PRK00855 742729002265 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 742729002266 active sites [active] 742729002267 tetramer interface [polypeptide binding]; other site 742729002268 acetoin reductases; Region: 23BDH; TIGR02415 742729002269 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 742729002270 NAD(P) binding site [chemical binding]; other site 742729002271 active site 742729002272 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 742729002273 Zn2+ binding site [ion binding]; other site 742729002274 Mg2+ binding site [ion binding]; other site 742729002275 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 742729002276 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 742729002277 active site 742729002278 HIGH motif; other site 742729002279 dimer interface [polypeptide binding]; other site 742729002280 KMSKS motif; other site 742729002281 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 742729002282 RNA binding surface [nucleotide binding]; other site 742729002283 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 742729002284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729002285 active site 742729002286 motif I; other site 742729002287 motif II; other site 742729002288 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729002289 motif II; other site 742729002290 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 742729002291 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 742729002292 RNA binding surface [nucleotide binding]; other site 742729002293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 742729002294 S-adenosylmethionine binding site [chemical binding]; other site 742729002295 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 742729002296 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 742729002297 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 742729002298 TrkA-N domain; Region: TrkA_N; pfam02254 742729002299 TrkA-C domain; Region: TrkA_C; pfam02080 742729002300 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 742729002301 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 742729002302 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 742729002303 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 742729002304 Walker A/P-loop; other site 742729002305 ATP binding site [chemical binding]; other site 742729002306 Q-loop/lid; other site 742729002307 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 742729002308 ABC transporter signature motif; other site 742729002309 Walker B; other site 742729002310 D-loop; other site 742729002311 H-loop/switch region; other site 742729002312 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 742729002313 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 742729002314 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729002315 motif II; other site 742729002316 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 742729002317 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 742729002318 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729002319 catalytic residue [active] 742729002320 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 742729002321 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 742729002322 putative catalytic cysteine [active] 742729002323 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 742729002324 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 742729002325 active site 742729002326 (T/H)XGH motif; other site 742729002327 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 742729002328 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 742729002329 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 742729002330 active site 742729002331 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 742729002332 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 742729002333 Substrate binding site; other site 742729002334 Mg++ binding site; other site 742729002335 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 742729002336 active site 742729002337 substrate binding site [chemical binding]; other site 742729002338 CoA binding site [chemical binding]; other site 742729002339 Oligomerisation domain; Region: Oligomerisation; pfam02410 742729002340 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 742729002341 catalytic core [active] 742729002342 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 742729002343 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 742729002344 catalytic core [active] 742729002345 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 742729002346 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 742729002347 Cl binding site [ion binding]; other site 742729002348 oligomer interface [polypeptide binding]; other site 742729002349 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 742729002350 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 742729002351 substrate binding pocket [chemical binding]; other site 742729002352 membrane-bound complex binding site; other site 742729002353 hinge residues; other site 742729002354 aminoacyl-tRNA ligase; Region: PLN02563 742729002355 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 742729002356 active site 742729002357 HIGH motif; other site 742729002358 nucleotide binding site [chemical binding]; other site 742729002359 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 742729002360 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 742729002361 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 742729002362 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 742729002363 active site 742729002364 KMSKS motif; other site 742729002365 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 742729002366 tRNA binding surface [nucleotide binding]; other site 742729002367 Helix-hairpin-helix motif; Region: HHH; pfam00633 742729002368 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 742729002369 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 742729002370 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 742729002371 Competence protein; Region: Competence; pfam03772 742729002372 hypothetical protein; Reviewed; Region: PRK07914 742729002373 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 742729002374 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 742729002375 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 742729002376 Glycoprotease family; Region: Peptidase_M22; pfam00814 742729002377 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 742729002378 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 742729002379 Coenzyme A binding pocket [chemical binding]; other site 742729002380 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 742729002381 UGMP family protein; Validated; Region: PRK09604 742729002382 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 742729002383 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 742729002384 isocitrate dehydrogenase; Validated; Region: PRK08299 742729002385 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 742729002386 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 742729002387 phosphate binding site [ion binding]; other site 742729002388 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 742729002389 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 742729002390 acyl-activating enzyme (AAE) consensus motif; other site 742729002391 putative AMP binding site [chemical binding]; other site 742729002392 putative active site [active] 742729002393 putative CoA binding site [chemical binding]; other site 742729002394 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 742729002395 active site 742729002396 catalytic residues [active] 742729002397 metal binding site [ion binding]; metal-binding site 742729002398 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 742729002399 rRNA interaction site [nucleotide binding]; other site 742729002400 S8 interaction site; other site 742729002401 putative laminin-1 binding site; other site 742729002402 elongation factor Ts; Provisional; Region: tsf; PRK09377 742729002403 UBA/TS-N domain; Region: UBA; pfam00627 742729002404 Elongation factor TS; Region: EF_TS; pfam00889 742729002405 Elongation factor TS; Region: EF_TS; pfam00889 742729002406 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 742729002407 putative nucleotide binding site [chemical binding]; other site 742729002408 uridine monophosphate binding site [chemical binding]; other site 742729002409 homohexameric interface [polypeptide binding]; other site 742729002410 ribosome recycling factor; Reviewed; Region: frr; PRK00083 742729002411 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 742729002412 hinge region; other site 742729002413 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 742729002414 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 742729002415 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 742729002416 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 742729002417 FeS/SAM binding site; other site 742729002418 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 742729002419 WHG domain; Region: WHG; pfam13305 742729002420 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 742729002421 Walker A/P-loop; other site 742729002422 ATP binding site [chemical binding]; other site 742729002423 ABC transporter; Region: ABC_tran; pfam00005 742729002424 Q-loop/lid; other site 742729002425 ABC transporter signature motif; other site 742729002426 Walker B; other site 742729002427 D-loop; other site 742729002428 H-loop/switch region; other site 742729002429 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 742729002430 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 742729002431 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 742729002432 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 742729002433 substrate binding site [chemical binding]; other site 742729002434 glutamase interaction surface [polypeptide binding]; other site 742729002435 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 742729002436 anthranilate synthase component I; Provisional; Region: PRK13571 742729002437 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 742729002438 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 742729002439 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 742729002440 putative uracil binding site [chemical binding]; other site 742729002441 putative active site [active] 742729002442 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 742729002443 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 742729002444 active site 742729002445 ribulose/triose binding site [chemical binding]; other site 742729002446 phosphate binding site [ion binding]; other site 742729002447 substrate (anthranilate) binding pocket [chemical binding]; other site 742729002448 product (indole) binding pocket [chemical binding]; other site 742729002449 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 742729002450 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729002451 catalytic residue [active] 742729002452 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 742729002453 substrate binding site [chemical binding]; other site 742729002454 active site 742729002455 catalytic residues [active] 742729002456 heterodimer interface [polypeptide binding]; other site 742729002457 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 742729002458 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 742729002459 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 742729002460 substrate binding site [chemical binding]; other site 742729002461 hexamer interface [polypeptide binding]; other site 742729002462 metal binding site [ion binding]; metal-binding site 742729002463 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 742729002464 homodimer interface [polypeptide binding]; other site 742729002465 putative metal binding site [ion binding]; other site 742729002466 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 742729002467 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 742729002468 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 742729002469 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 742729002470 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 742729002471 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 742729002472 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 742729002473 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 742729002474 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 742729002475 phosphopeptide binding site; other site 742729002476 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 742729002477 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 742729002478 DNA binding residues [nucleotide binding] 742729002479 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 742729002480 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 742729002481 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729002482 motif II; other site 742729002483 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 742729002484 DEAD-like helicases superfamily; Region: DEXDc; smart00487 742729002485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 742729002486 ATP binding site [chemical binding]; other site 742729002487 putative Mg++ binding site [ion binding]; other site 742729002488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729002489 nucleotide binding region [chemical binding]; other site 742729002490 ATP-binding site [chemical binding]; other site 742729002491 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 742729002492 Predicted transcriptional regulator [Transcription]; Region: COG2378 742729002493 WYL domain; Region: WYL; pfam13280 742729002494 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 742729002495 active site 742729002496 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 742729002497 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 742729002498 active site 742729002499 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 742729002500 CMP-binding site; other site 742729002501 The sites determining sugar specificity; other site 742729002502 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 742729002503 G1 box; other site 742729002504 GTP/Mg2+ binding site [chemical binding]; other site 742729002505 Switch I region; other site 742729002506 G2 box; other site 742729002507 Switch II region; other site 742729002508 G3 box; other site 742729002509 G4 box; other site 742729002510 G5 box; other site 742729002511 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 742729002512 G1 box; other site 742729002513 GTP/Mg2+ binding site [chemical binding]; other site 742729002514 Switch I region; other site 742729002515 G2 box; other site 742729002516 G3 box; other site 742729002517 Switch II region; other site 742729002518 G4 box; other site 742729002519 G5 box; other site 742729002520 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 742729002521 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 742729002522 RNA binding surface [nucleotide binding]; other site 742729002523 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 742729002524 active site 742729002525 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 742729002526 amphipathic channel; other site 742729002527 Asn-Pro-Ala signature motifs; other site 742729002528 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 742729002529 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 742729002530 purine monophosphate binding site [chemical binding]; other site 742729002531 dimer interface [polypeptide binding]; other site 742729002532 putative catalytic residues [active] 742729002533 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 742729002534 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 742729002535 CoA binding domain; Region: CoA_binding; pfam02629 742729002536 CoA-ligase; Region: Ligase_CoA; pfam00549 742729002537 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 742729002538 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 742729002539 CoA-ligase; Region: Ligase_CoA; pfam00549 742729002540 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 742729002541 active site 742729002542 Preprotein translocase subunit; Region: YajC; pfam02699 742729002543 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 742729002544 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729002545 Walker A motif; other site 742729002546 ATP binding site [chemical binding]; other site 742729002547 Walker B motif; other site 742729002548 arginine finger; other site 742729002549 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 742729002550 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 742729002551 RuvA N terminal domain; Region: RuvA_N; pfam01330 742729002552 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 742729002553 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 742729002554 active site 742729002555 putative DNA-binding cleft [nucleotide binding]; other site 742729002556 dimer interface [polypeptide binding]; other site 742729002557 hypothetical protein; Validated; Region: PRK00110 742729002558 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 742729002559 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 742729002560 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK07920 742729002561 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 742729002562 putative acyl-acceptor binding pocket; other site 742729002563 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 742729002564 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 742729002565 thiS-thiF/thiG interaction site; other site 742729002566 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 742729002567 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 742729002568 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 742729002569 active site 742729002570 dimer interface [polypeptide binding]; other site 742729002571 motif 1; other site 742729002572 motif 2; other site 742729002573 motif 3; other site 742729002574 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 742729002575 anticodon binding site; other site 742729002576 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 742729002577 ABC transporter; Region: ABC_tran; pfam00005 742729002578 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 742729002579 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 742729002580 Coenzyme A binding pocket [chemical binding]; other site 742729002581 PAC2 family; Region: PAC2; pfam09754 742729002582 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 742729002583 Fructosamine kinase; Region: Fructosamin_kin; cl17579 742729002584 chaperone protein DnaJ; Provisional; Region: PRK14278 742729002585 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 742729002586 HSP70 interaction site [polypeptide binding]; other site 742729002587 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 742729002588 Zn binding sites [ion binding]; other site 742729002589 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 742729002590 dimer interface [polypeptide binding]; other site 742729002591 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 742729002592 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 742729002593 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 742729002594 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 742729002595 TPP-binding site [chemical binding]; other site 742729002596 dimer interface [polypeptide binding]; other site 742729002597 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 742729002598 PYR/PP interface [polypeptide binding]; other site 742729002599 dimer interface [polypeptide binding]; other site 742729002600 TPP binding site [chemical binding]; other site 742729002601 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 742729002602 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 742729002603 putative active site [active] 742729002604 transaldolase; Provisional; Region: PRK03903 742729002605 catalytic residue [active] 742729002606 hypothetical protein; Validated; Region: PRK07682 742729002607 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729002608 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729002609 homodimer interface [polypeptide binding]; other site 742729002610 catalytic residue [active] 742729002611 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 742729002612 AsnC family; Region: AsnC_trans_reg; pfam01037 742729002613 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 742729002614 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 742729002615 non-specific DNA binding site [nucleotide binding]; other site 742729002616 salt bridge; other site 742729002617 sequence-specific DNA binding site [nucleotide binding]; other site 742729002618 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729002619 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729002620 homodimer interface [polypeptide binding]; other site 742729002621 catalytic residue [active] 742729002622 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 742729002623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729002624 active site 742729002625 motif I; other site 742729002626 motif II; other site 742729002627 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729002628 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 742729002629 triosephosphate isomerase; Provisional; Region: PRK14567 742729002630 substrate binding site [chemical binding]; other site 742729002631 dimer interface [polypeptide binding]; other site 742729002632 catalytic triad [active] 742729002633 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 742729002634 Phosphoglycerate kinase; Region: PGK; pfam00162 742729002635 substrate binding site [chemical binding]; other site 742729002636 hinge regions; other site 742729002637 ADP binding site [chemical binding]; other site 742729002638 catalytic site [active] 742729002639 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 742729002640 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 742729002641 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 742729002642 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 742729002643 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 742729002644 shikimate binding site; other site 742729002645 NAD(P) binding site [chemical binding]; other site 742729002646 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 742729002647 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 742729002648 GIY-YIG motif/motif A; other site 742729002649 active site 742729002650 catalytic site [active] 742729002651 putative DNA binding site [nucleotide binding]; other site 742729002652 metal binding site [ion binding]; metal-binding site 742729002653 UvrB/uvrC motif; Region: UVR; pfam02151 742729002654 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 742729002655 Helix-hairpin-helix motif; Region: HHH; pfam00633 742729002656 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 742729002657 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 742729002658 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 742729002659 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 742729002660 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 742729002661 putative active site [active] 742729002662 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 742729002663 Predicted esterase [General function prediction only]; Region: COG0400 742729002664 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 742729002665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729002666 Walker A/P-loop; other site 742729002667 ATP binding site [chemical binding]; other site 742729002668 Q-loop/lid; other site 742729002669 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 742729002670 ABC transporter signature motif; other site 742729002671 Walker B; other site 742729002672 D-loop; other site 742729002673 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 742729002674 Cation efflux family; Region: Cation_efflux; pfam01545 742729002675 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 742729002676 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 742729002677 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 742729002678 active site 742729002679 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 742729002680 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 742729002681 putative substrate binding site [chemical binding]; other site 742729002682 putative ATP binding site [chemical binding]; other site 742729002683 peroxiredoxin; Region: AhpC; TIGR03137 742729002684 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 742729002685 dimer interface [polypeptide binding]; other site 742729002686 decamer (pentamer of dimers) interface [polypeptide binding]; other site 742729002687 catalytic triad [active] 742729002688 peroxidatic and resolving cysteines [active] 742729002689 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 742729002690 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 742729002691 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 742729002692 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 742729002693 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 742729002694 Transcriptional regulator [Transcription]; Region: LysR; COG0583 742729002695 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 742729002696 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 742729002697 dimerization interface [polypeptide binding]; other site 742729002698 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 742729002699 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729002700 motif II; other site 742729002701 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 742729002702 putative active site [active] 742729002703 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 742729002704 Predicted transcriptional regulators [Transcription]; Region: COG1733 742729002705 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 742729002706 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 742729002707 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 742729002708 Coenzyme A binding pocket [chemical binding]; other site 742729002709 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 742729002710 active site 742729002711 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 742729002712 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 742729002713 heterodimer interface [polypeptide binding]; other site 742729002714 active site 742729002715 FMN binding site [chemical binding]; other site 742729002716 homodimer interface [polypeptide binding]; other site 742729002717 substrate binding site [chemical binding]; other site 742729002718 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 742729002719 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 742729002720 FAD binding pocket [chemical binding]; other site 742729002721 FAD binding motif [chemical binding]; other site 742729002722 phosphate binding motif [ion binding]; other site 742729002723 beta-alpha-beta structure motif; other site 742729002724 NAD binding pocket [chemical binding]; other site 742729002725 Iron coordination center [ion binding]; other site 742729002726 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 742729002727 active site 742729002728 dimer interface [polypeptide binding]; other site 742729002729 dihydroorotase; Validated; Region: pyrC; PRK09357 742729002730 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 742729002731 active site 742729002732 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 742729002733 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 742729002734 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 742729002735 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 742729002736 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 742729002737 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 742729002738 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 742729002739 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 742729002740 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 742729002741 metal binding triad; other site 742729002742 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 742729002743 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 742729002744 metal binding triad; other site 742729002745 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 742729002746 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 742729002747 FAD binding site [chemical binding]; other site 742729002748 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 742729002749 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 742729002750 THF binding site; other site 742729002751 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 742729002752 substrate binding site [chemical binding]; other site 742729002753 THF binding site; other site 742729002754 zinc-binding site [ion binding]; other site 742729002755 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 742729002756 catalytic core [active] 742729002757 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 742729002758 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 742729002759 S-adenosylmethionine binding site [chemical binding]; other site 742729002760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729002761 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 742729002762 Walker A/P-loop; other site 742729002763 ATP binding site [chemical binding]; other site 742729002764 Q-loop/lid; other site 742729002765 ABC transporter signature motif; other site 742729002766 Walker B; other site 742729002767 D-loop; other site 742729002768 H-loop/switch region; other site 742729002769 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 742729002770 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 742729002771 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 742729002772 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 742729002773 catalytic triad [active] 742729002774 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 742729002775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 742729002776 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 742729002777 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 742729002778 active site 742729002779 dimer interface [polypeptide binding]; other site 742729002780 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 742729002781 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 742729002782 active site 742729002783 FMN binding site [chemical binding]; other site 742729002784 substrate binding site [chemical binding]; other site 742729002785 3Fe-4S cluster binding site [ion binding]; other site 742729002786 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 742729002787 domain interface; other site 742729002788 coproporphyrinogen III oxidase; Validated; Region: PRK05628 742729002789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 742729002790 FeS/SAM binding site; other site 742729002791 HemN C-terminal domain; Region: HemN_C; pfam06969 742729002792 GTP-binding protein LepA; Provisional; Region: PRK05433 742729002793 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 742729002794 G1 box; other site 742729002795 putative GEF interaction site [polypeptide binding]; other site 742729002796 GTP/Mg2+ binding site [chemical binding]; other site 742729002797 Switch I region; other site 742729002798 G2 box; other site 742729002799 G3 box; other site 742729002800 Switch II region; other site 742729002801 G4 box; other site 742729002802 G5 box; other site 742729002803 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 742729002804 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 742729002805 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 742729002806 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 742729002807 UPF0126 domain; Region: UPF0126; pfam03458 742729002808 Predicted membrane protein [Function unknown]; Region: COG2860 742729002809 UPF0126 domain; Region: UPF0126; pfam03458 742729002810 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 742729002811 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 742729002812 homodimer interface [polypeptide binding]; other site 742729002813 substrate-cofactor binding pocket; other site 742729002814 catalytic residue [active] 742729002815 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 742729002816 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 742729002817 5S rRNA interface [nucleotide binding]; other site 742729002818 CTC domain interface [polypeptide binding]; other site 742729002819 L16 interface [polypeptide binding]; other site 742729002820 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 742729002821 Serine hydrolase (FSH1); Region: FSH1; pfam03959 742729002822 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 742729002823 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 742729002824 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 742729002825 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 742729002826 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 742729002827 ligand binding site [chemical binding]; other site 742729002828 homodimer interface [polypeptide binding]; other site 742729002829 NAD(P) binding site [chemical binding]; other site 742729002830 trimer interface B [polypeptide binding]; other site 742729002831 trimer interface A [polypeptide binding]; other site 742729002832 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 742729002833 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 742729002834 acyl-activating enzyme (AAE) consensus motif; other site 742729002835 putative AMP binding site [chemical binding]; other site 742729002836 putative active site [active] 742729002837 putative CoA binding site [chemical binding]; other site 742729002838 GTPase Era; Reviewed; Region: era; PRK00089 742729002839 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 742729002840 G1 box; other site 742729002841 GTP/Mg2+ binding site [chemical binding]; other site 742729002842 Switch I region; other site 742729002843 G2 box; other site 742729002844 Switch II region; other site 742729002845 G3 box; other site 742729002846 G4 box; other site 742729002847 G5 box; other site 742729002848 KH domain; Region: KH_2; pfam07650 742729002849 Domain of unknown function DUF21; Region: DUF21; pfam01595 742729002850 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 742729002851 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 742729002852 Transporter associated domain; Region: CorC_HlyC; smart01091 742729002853 metal-binding heat shock protein; Provisional; Region: PRK00016 742729002854 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 742729002855 PhoH-like protein; Region: PhoH; pfam02562 742729002856 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 742729002857 nucleotide binding site/active site [active] 742729002858 HIT family signature motif; other site 742729002859 catalytic residue [active] 742729002860 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 742729002861 RNA methyltransferase, RsmE family; Region: TIGR00046 742729002862 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 742729002863 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 742729002864 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 742729002865 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 742729002866 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 742729002867 ligand binding site; other site 742729002868 oligomer interface; other site 742729002869 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 742729002870 dimer interface [polypeptide binding]; other site 742729002871 N-terminal domain interface [polypeptide binding]; other site 742729002872 sulfate 1 binding site; other site 742729002873 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 742729002874 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 742729002875 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 742729002876 trimerization site [polypeptide binding]; other site 742729002877 active site 742729002878 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 742729002879 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 742729002880 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 742729002881 catalytic residue [active] 742729002882 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 742729002883 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 742729002884 Walker A/P-loop; other site 742729002885 ATP binding site [chemical binding]; other site 742729002886 Q-loop/lid; other site 742729002887 ABC transporter signature motif; other site 742729002888 Walker B; other site 742729002889 D-loop; other site 742729002890 H-loop/switch region; other site 742729002891 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 742729002892 FeS assembly protein SufD; Region: sufD; TIGR01981 742729002893 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 742729002894 FeS assembly protein SufB; Region: sufB; TIGR01980 742729002895 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 742729002896 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 742729002897 CTP synthetase; Validated; Region: pyrG; PRK05380 742729002898 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 742729002899 Catalytic site [active] 742729002900 active site 742729002901 UTP binding site [chemical binding]; other site 742729002902 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 742729002903 active site 742729002904 putative oxyanion hole; other site 742729002905 catalytic triad [active] 742729002906 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 742729002907 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 742729002908 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 742729002909 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 742729002910 active site 742729002911 catalytic site [active] 742729002912 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 742729002913 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 742729002914 active site 742729002915 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 742729002916 catalytic nucleophile [active] 742729002917 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 742729002918 GIY-YIG motif/motif A; other site 742729002919 putative active site [active] 742729002920 putative metal binding site [ion binding]; other site 742729002921 Dehydroquinase class II; Region: DHquinase_II; pfam01220 742729002922 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 742729002923 trimer interface [polypeptide binding]; other site 742729002924 active site 742729002925 dimer interface [polypeptide binding]; other site 742729002926 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 742729002927 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 742729002928 ADP binding site [chemical binding]; other site 742729002929 magnesium binding site [ion binding]; other site 742729002930 putative shikimate binding site; other site 742729002931 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 742729002932 active site 742729002933 dimer interface [polypeptide binding]; other site 742729002934 metal binding site [ion binding]; metal-binding site 742729002935 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 742729002936 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 742729002937 Tetramer interface [polypeptide binding]; other site 742729002938 active site 742729002939 FMN-binding site [chemical binding]; other site 742729002940 YceG-like family; Region: YceG; pfam02618 742729002941 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 742729002942 dimerization interface [polypeptide binding]; other site 742729002943 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 742729002944 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 742729002945 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 742729002946 motif 1; other site 742729002947 active site 742729002948 motif 2; other site 742729002949 motif 3; other site 742729002950 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 742729002951 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 742729002952 catalytic core [active] 742729002953 Membrane protein of unknown function; Region: DUF360; pfam04020 742729002954 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 742729002955 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 742729002956 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 742729002957 RNA binding surface [nucleotide binding]; other site 742729002958 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 742729002959 Part of AAA domain; Region: AAA_19; pfam13245 742729002960 Family description; Region: UvrD_C_2; pfam13538 742729002961 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 742729002962 active site 742729002963 xanthine permease; Region: pbuX; TIGR03173 742729002964 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 742729002965 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 742729002966 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729002967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729002968 homodimer interface [polypeptide binding]; other site 742729002969 catalytic residue [active] 742729002970 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 742729002971 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 742729002972 active site 742729002973 Na/Ca binding site [ion binding]; other site 742729002974 catalytic site [active] 742729002975 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 742729002976 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 742729002977 catalytic triad [active] 742729002978 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 742729002979 putative deacylase active site [active] 742729002980 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 742729002981 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 742729002982 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 742729002983 Walker A/P-loop; other site 742729002984 ATP binding site [chemical binding]; other site 742729002985 Q-loop/lid; other site 742729002986 ABC transporter signature motif; other site 742729002987 Walker B; other site 742729002988 D-loop; other site 742729002989 H-loop/switch region; other site 742729002990 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 742729002991 DNA-binding site [nucleotide binding]; DNA binding site 742729002992 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 742729002993 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 742729002994 non-specific DNA binding site [nucleotide binding]; other site 742729002995 salt bridge; other site 742729002996 sequence-specific DNA binding site [nucleotide binding]; other site 742729002997 adenosine deaminase; Provisional; Region: PRK09358 742729002998 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 742729002999 active site 742729003000 Chorismate mutase type II; Region: CM_2; cl00693 742729003001 hypothetical protein; Provisional; Region: PRK06761 742729003002 hypothetical protein; Provisional; Region: PRK06761 742729003003 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 742729003004 Coenzyme A binding pocket [chemical binding]; other site 742729003005 AAA domain; Region: AAA_17; pfam13207 742729003006 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 742729003007 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 742729003008 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 742729003009 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 742729003010 G1 box; other site 742729003011 putative GEF interaction site [polypeptide binding]; other site 742729003012 GTP/Mg2+ binding site [chemical binding]; other site 742729003013 Switch I region; other site 742729003014 G2 box; other site 742729003015 G3 box; other site 742729003016 Switch II region; other site 742729003017 G4 box; other site 742729003018 G5 box; other site 742729003019 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 742729003020 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 742729003021 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 742729003022 Transposase domain (DUF772); Region: DUF772; pfam05598 742729003023 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 742729003024 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 742729003025 GMP synthase; Reviewed; Region: guaA; PRK00074 742729003026 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 742729003027 AMP/PPi binding site [chemical binding]; other site 742729003028 candidate oxyanion hole; other site 742729003029 catalytic triad [active] 742729003030 potential glutamine specificity residues [chemical binding]; other site 742729003031 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 742729003032 ATP Binding subdomain [chemical binding]; other site 742729003033 Ligand Binding sites [chemical binding]; other site 742729003034 Dimerization subdomain; other site 742729003035 putative phosphoketolase; Provisional; Region: PRK05261 742729003036 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 742729003037 TPP-binding site; other site 742729003038 XFP C-terminal domain; Region: XFP_C; pfam09363 742729003039 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 742729003040 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 742729003041 propionate/acetate kinase; Provisional; Region: PRK12379 742729003042 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 742729003043 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 742729003044 hinge; other site 742729003045 active site 742729003046 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 742729003047 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 742729003048 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 742729003049 active site 742729003050 catalytic site [active] 742729003051 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 742729003052 dimer interface [polypeptide binding]; other site 742729003053 ADP-ribose binding site [chemical binding]; other site 742729003054 active site 742729003055 nudix motif; other site 742729003056 metal binding site [ion binding]; metal-binding site 742729003057 Uncharacterized conserved protein [Function unknown]; Region: COG0327 742729003058 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 742729003059 DNA polymerase I; Provisional; Region: PRK05755 742729003060 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 742729003061 active site 742729003062 metal binding site 1 [ion binding]; metal-binding site 742729003063 putative 5' ssDNA interaction site; other site 742729003064 metal binding site 3; metal-binding site 742729003065 metal binding site 2 [ion binding]; metal-binding site 742729003066 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 742729003067 putative DNA binding site [nucleotide binding]; other site 742729003068 putative metal binding site [ion binding]; other site 742729003069 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 742729003070 active site 742729003071 substrate binding site [chemical binding]; other site 742729003072 catalytic site [active] 742729003073 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 742729003074 active site 742729003075 DNA binding site [nucleotide binding] 742729003076 catalytic site [active] 742729003077 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 742729003078 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 742729003079 active site 742729003080 phosphorylation site [posttranslational modification] 742729003081 intermolecular recognition site; other site 742729003082 dimerization interface [polypeptide binding]; other site 742729003083 ANTAR domain; Region: ANTAR; pfam03861 742729003084 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 742729003085 dimer interface [polypeptide binding]; other site 742729003086 ADP-ribose binding site [chemical binding]; other site 742729003087 active site 742729003088 nudix motif; other site 742729003089 metal binding site [ion binding]; metal-binding site 742729003090 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 742729003091 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 742729003092 active site 742729003093 domain interfaces; other site 742729003094 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 742729003095 excinuclease ABC subunit B; Provisional; Region: PRK05298 742729003096 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 742729003097 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729003098 nucleotide binding region [chemical binding]; other site 742729003099 ATP-binding site [chemical binding]; other site 742729003100 Ultra-violet resistance protein B; Region: UvrB; pfam12344 742729003101 UvrB/uvrC motif; Region: UVR; pfam02151 742729003102 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 742729003103 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 742729003104 CoA-binding site [chemical binding]; other site 742729003105 ATP-binding [chemical binding]; other site 742729003106 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 742729003107 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 742729003108 RNA binding site [nucleotide binding]; other site 742729003109 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 742729003110 RNA binding site [nucleotide binding]; other site 742729003111 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 742729003112 RNA binding site [nucleotide binding]; other site 742729003113 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 742729003114 RNA binding site [nucleotide binding]; other site 742729003115 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 742729003116 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 742729003117 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 742729003118 homodimer interface [polypeptide binding]; other site 742729003119 NADP binding site [chemical binding]; other site 742729003120 substrate binding site [chemical binding]; other site 742729003121 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 742729003122 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 742729003123 intersubunit interface [polypeptide binding]; other site 742729003124 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 742729003125 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 742729003126 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 742729003127 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 742729003128 ABC-ATPase subunit interface; other site 742729003129 dimer interface [polypeptide binding]; other site 742729003130 putative PBP binding regions; other site 742729003131 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 742729003132 homotrimer interaction site [polypeptide binding]; other site 742729003133 zinc binding site [ion binding]; other site 742729003134 CDP-binding sites; other site 742729003135 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 742729003136 glycogen branching enzyme; Provisional; Region: PRK05402 742729003137 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 742729003138 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 742729003139 active site 742729003140 catalytic site [active] 742729003141 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 742729003142 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 742729003143 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 742729003144 active site 742729003145 phosphorylation site [posttranslational modification] 742729003146 intermolecular recognition site; other site 742729003147 dimerization interface [polypeptide binding]; other site 742729003148 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 742729003149 DNA binding site [nucleotide binding] 742729003150 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 742729003151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 742729003152 dimerization interface [polypeptide binding]; other site 742729003153 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 742729003154 dimer interface [polypeptide binding]; other site 742729003155 phosphorylation site [posttranslational modification] 742729003156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 742729003157 ATP binding site [chemical binding]; other site 742729003158 Mg2+ binding site [ion binding]; other site 742729003159 G-X-G motif; other site 742729003160 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 742729003161 active site 742729003162 Eukaryotic phosphomannomutase; Region: PMM; cl17107 742729003163 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 742729003164 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 742729003165 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 742729003166 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 742729003167 Transcriptional regulator [Transcription]; Region: LytR; COG1316 742729003168 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 742729003169 Transcription factor WhiB; Region: Whib; pfam02467 742729003170 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 742729003171 PAS fold; Region: PAS_4; pfam08448 742729003172 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 742729003173 Histidine kinase; Region: HisKA_2; pfam07568 742729003174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 742729003175 ATP binding site [chemical binding]; other site 742729003176 Mg2+ binding site [ion binding]; other site 742729003177 G-X-G motif; other site 742729003178 V-type ATP synthase subunit E; Provisional; Region: PRK01558 742729003179 Haemolysin-III related; Region: HlyIII; pfam03006 742729003180 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 742729003181 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 742729003182 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 742729003183 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 742729003184 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 742729003185 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 742729003186 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 742729003187 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 742729003188 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 742729003189 Protein of unknown function (DUF501); Region: DUF501; pfam04417 742729003190 Septum formation initiator; Region: DivIC; pfam04977 742729003191 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 742729003192 enolase; Provisional; Region: eno; PRK00077 742729003193 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 742729003194 dimer interface [polypeptide binding]; other site 742729003195 metal binding site [ion binding]; metal-binding site 742729003196 substrate binding pocket [chemical binding]; other site 742729003197 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 742729003198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729003199 dimer interface [polypeptide binding]; other site 742729003200 conserved gate region; other site 742729003201 putative PBP binding loops; other site 742729003202 ABC-ATPase subunit interface; other site 742729003203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 742729003204 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 742729003205 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 742729003206 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 742729003207 Walker A/P-loop; other site 742729003208 ATP binding site [chemical binding]; other site 742729003209 Q-loop/lid; other site 742729003210 ABC transporter signature motif; other site 742729003211 Walker B; other site 742729003212 D-loop; other site 742729003213 H-loop/switch region; other site 742729003214 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 742729003215 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 742729003216 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 742729003217 ATP binding site [chemical binding]; other site 742729003218 putative Mg++ binding site [ion binding]; other site 742729003219 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729003220 nucleotide binding region [chemical binding]; other site 742729003221 ATP-binding site [chemical binding]; other site 742729003222 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 742729003223 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 742729003224 putative active site [active] 742729003225 catalytic residue [active] 742729003226 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 742729003227 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 742729003228 Coenzyme A binding pocket [chemical binding]; other site 742729003229 Uncharacterized conserved protein [Function unknown]; Region: COG1615 742729003230 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 742729003231 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 742729003232 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 742729003233 Protein of unknown function (DUF466); Region: DUF466; cl01082 742729003234 carbon starvation protein A; Provisional; Region: PRK15015 742729003235 Carbon starvation protein CstA; Region: CstA; pfam02554 742729003236 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 742729003237 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729003238 H-loop/switch region; other site 742729003239 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729003240 ABC transporter signature motif; other site 742729003241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 742729003242 Q-loop/lid; other site 742729003243 ABC transporter signature motif; other site 742729003244 Walker B; other site 742729003245 D-loop; other site 742729003246 H-loop/switch region; other site 742729003247 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 742729003248 MarR family; Region: MarR_2; pfam12802 742729003249 Ubinuclein conserved middle domain; Region: UBN_AB; pfam14075 742729003250 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 742729003251 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 742729003252 Aspartase; Region: Aspartase; cd01357 742729003253 active sites [active] 742729003254 tetramer interface [polypeptide binding]; other site 742729003255 FeoA domain; Region: FeoA; pfam04023 742729003256 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 742729003257 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 742729003258 G1 box; other site 742729003259 GTP/Mg2+ binding site [chemical binding]; other site 742729003260 Switch I region; other site 742729003261 G2 box; other site 742729003262 G3 box; other site 742729003263 Switch II region; other site 742729003264 G4 box; other site 742729003265 G5 box; other site 742729003266 Nucleoside recognition; Region: Gate; pfam07670 742729003267 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 742729003268 Nucleoside recognition; Region: Gate; pfam07670 742729003269 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 742729003270 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 742729003271 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 742729003272 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 742729003273 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 742729003274 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 742729003275 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 742729003276 putative active site [active] 742729003277 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 742729003278 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 742729003279 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 742729003280 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 742729003281 catalytic triad [active] 742729003282 active site nucleophile [active] 742729003283 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 742729003284 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 742729003285 SelR domain; Region: SelR; pfam01641 742729003286 methionine sulfoxide reductase B; Provisional; Region: PRK00222 742729003287 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 742729003288 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 742729003289 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 742729003290 Soluble P-type ATPase [General function prediction only]; Region: COG4087 742729003291 Uncharacterized conserved protein [Function unknown]; Region: COG3350 742729003292 classical (c) SDRs; Region: SDR_c; cd05233 742729003293 NAD(P) binding site [chemical binding]; other site 742729003294 active site 742729003295 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 742729003296 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 742729003297 ATP binding site [chemical binding]; other site 742729003298 Mg++ binding site [ion binding]; other site 742729003299 motif III; other site 742729003300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729003301 nucleotide binding region [chemical binding]; other site 742729003302 ATP-binding site [chemical binding]; other site 742729003303 Predicted membrane protein [Function unknown]; Region: COG2855 742729003304 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 742729003305 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 742729003306 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 742729003307 substrate binding pocket [chemical binding]; other site 742729003308 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 742729003309 GTP-binding protein YchF; Reviewed; Region: PRK09601 742729003310 YchF GTPase; Region: YchF; cd01900 742729003311 G1 box; other site 742729003312 GTP/Mg2+ binding site [chemical binding]; other site 742729003313 Switch I region; other site 742729003314 G2 box; other site 742729003315 Switch II region; other site 742729003316 G3 box; other site 742729003317 G4 box; other site 742729003318 G5 box; other site 742729003319 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 742729003320 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 742729003321 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 742729003322 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 742729003323 Histidine kinase; Region: HisKA_3; pfam07730 742729003324 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 742729003325 ATP binding site [chemical binding]; other site 742729003326 Mg2+ binding site [ion binding]; other site 742729003327 G-X-G motif; other site 742729003328 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 742729003329 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 742729003330 active site 742729003331 phosphorylation site [posttranslational modification] 742729003332 intermolecular recognition site; other site 742729003333 dimerization interface [polypeptide binding]; other site 742729003334 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 742729003335 DNA binding residues [nucleotide binding] 742729003336 dimerization interface [polypeptide binding]; other site 742729003337 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 742729003338 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 742729003339 FtsX-like permease family; Region: FtsX; pfam02687 742729003340 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 742729003341 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 742729003342 Walker A/P-loop; other site 742729003343 ATP binding site [chemical binding]; other site 742729003344 Q-loop/lid; other site 742729003345 ABC transporter signature motif; other site 742729003346 Walker B; other site 742729003347 D-loop; other site 742729003348 H-loop/switch region; other site 742729003349 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 742729003350 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 742729003351 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 742729003352 Walker A/P-loop; other site 742729003353 ATP binding site [chemical binding]; other site 742729003354 Q-loop/lid; other site 742729003355 ABC transporter signature motif; other site 742729003356 Walker B; other site 742729003357 D-loop; other site 742729003358 H-loop/switch region; other site 742729003359 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 742729003360 Walker A/P-loop; other site 742729003361 ATP binding site [chemical binding]; other site 742729003362 Q-loop/lid; other site 742729003363 ABC transporter signature motif; other site 742729003364 Walker B; other site 742729003365 D-loop; other site 742729003366 H-loop/switch region; other site 742729003367 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 742729003368 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 742729003369 homodimer interface [polypeptide binding]; other site 742729003370 substrate-cofactor binding pocket; other site 742729003371 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729003372 catalytic residue [active] 742729003373 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 742729003374 dimer interface [polypeptide binding]; other site 742729003375 pyridoxal binding site [chemical binding]; other site 742729003376 ATP binding site [chemical binding]; other site 742729003377 hypothetical protein; Provisional; Region: PRK14681 742729003378 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 742729003379 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 742729003380 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729003381 Walker A motif; other site 742729003382 ATP binding site [chemical binding]; other site 742729003383 Walker B motif; other site 742729003384 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 742729003385 DNA protecting protein DprA; Region: dprA; TIGR00732 742729003386 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 742729003387 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 742729003388 L-aspartate oxidase; Provisional; Region: PRK06175 742729003389 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 742729003390 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 742729003391 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 742729003392 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 742729003393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 742729003394 S-adenosylmethionine binding site [chemical binding]; other site 742729003395 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 742729003396 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 742729003397 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 742729003398 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729003399 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729003400 homodimer interface [polypeptide binding]; other site 742729003401 catalytic residue [active] 742729003402 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 742729003403 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 742729003404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729003405 Walker A motif; other site 742729003406 ATP binding site [chemical binding]; other site 742729003407 Walker B motif; other site 742729003408 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 742729003409 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 742729003410 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 742729003411 oligomer interface [polypeptide binding]; other site 742729003412 active site residues [active] 742729003413 Clp protease; Region: CLP_protease; pfam00574 742729003414 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 742729003415 oligomer interface [polypeptide binding]; other site 742729003416 active site residues [active] 742729003417 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 742729003418 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 742729003419 putative ion selectivity filter; other site 742729003420 putative pore gating glutamate residue; other site 742729003421 trigger factor; Provisional; Region: tig; PRK01490 742729003422 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 742729003423 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 742729003424 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 742729003425 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 742729003426 active site 742729003427 catalytic site [active] 742729003428 substrate binding site [chemical binding]; other site 742729003429 HRDC domain; Region: HRDC; pfam00570 742729003430 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 742729003431 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 742729003432 FeS/SAM binding site; other site 742729003433 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 742729003434 Pyruvate formate lyase 1; Region: PFL1; cd01678 742729003435 coenzyme A binding site [chemical binding]; other site 742729003436 active site 742729003437 catalytic residues [active] 742729003438 glycine loop; other site 742729003439 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 742729003440 NAD synthetase; Provisional; Region: PRK13981 742729003441 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 742729003442 multimer interface [polypeptide binding]; other site 742729003443 active site 742729003444 catalytic triad [active] 742729003445 protein interface 1 [polypeptide binding]; other site 742729003446 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 742729003447 homodimer interface [polypeptide binding]; other site 742729003448 NAD binding pocket [chemical binding]; other site 742729003449 ATP binding pocket [chemical binding]; other site 742729003450 Mg binding site [ion binding]; other site 742729003451 active-site loop [active] 742729003452 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 742729003453 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 742729003454 metal binding site [ion binding]; metal-binding site 742729003455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729003456 conserved gate region; other site 742729003457 ABC-ATPase subunit interface; other site 742729003458 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 742729003459 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 742729003460 Walker A/P-loop; other site 742729003461 ATP binding site [chemical binding]; other site 742729003462 Q-loop/lid; other site 742729003463 ABC transporter signature motif; other site 742729003464 Walker B; other site 742729003465 D-loop; other site 742729003466 H-loop/switch region; other site 742729003467 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 742729003468 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 742729003469 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 742729003470 active site 742729003471 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 742729003472 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 742729003473 Zn2+ binding site [ion binding]; other site 742729003474 Mg2+ binding site [ion binding]; other site 742729003475 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 742729003476 synthetase active site [active] 742729003477 NTP binding site [chemical binding]; other site 742729003478 metal binding site [ion binding]; metal-binding site 742729003479 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 742729003480 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 742729003481 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 742729003482 trimer interface [polypeptide binding]; other site 742729003483 active site 742729003484 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 742729003485 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 742729003486 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 742729003487 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 742729003488 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 742729003489 CAP-like domain; other site 742729003490 active site 742729003491 primary dimer interface [polypeptide binding]; other site 742729003492 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 742729003493 EamA-like transporter family; Region: EamA; cl17759 742729003494 DEAD-like helicases superfamily; Region: DEXDc; smart00487 742729003495 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 742729003496 ATP binding site [chemical binding]; other site 742729003497 putative Mg++ binding site [ion binding]; other site 742729003498 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 742729003499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729003500 nucleotide binding region [chemical binding]; other site 742729003501 ATP-binding site [chemical binding]; other site 742729003502 DEAD/H associated; Region: DEAD_assoc; pfam08494 742729003503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729003504 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729003505 putative substrate translocation pore; other site 742729003506 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 742729003507 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 742729003508 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 742729003509 ATP binding site [chemical binding]; other site 742729003510 Mg2+ binding site [ion binding]; other site 742729003511 G-X-G motif; other site 742729003512 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 742729003513 anchoring element; other site 742729003514 dimer interface [polypeptide binding]; other site 742729003515 ATP binding site [chemical binding]; other site 742729003516 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 742729003517 active site 742729003518 putative metal-binding site [ion binding]; other site 742729003519 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 742729003520 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 742729003521 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 742729003522 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 742729003523 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 742729003524 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 742729003525 DNA binding residues [nucleotide binding] 742729003526 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 742729003527 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 742729003528 substrate binding pocket [chemical binding]; other site 742729003529 chain length determination region; other site 742729003530 substrate-Mg2+ binding site; other site 742729003531 catalytic residues [active] 742729003532 aspartate-rich region 1; other site 742729003533 active site lid residues [active] 742729003534 aspartate-rich region 2; other site 742729003535 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 742729003536 Catalytic domain of Protein Kinases; Region: PKc; cd00180 742729003537 active site 742729003538 ATP binding site [chemical binding]; other site 742729003539 substrate binding site [chemical binding]; other site 742729003540 activation loop (A-loop); other site 742729003541 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 742729003542 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 742729003543 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 742729003544 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 742729003545 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 742729003546 putative acyl-acceptor binding pocket; other site 742729003547 TrbC/VIRB2 family; Region: TrbC; pfam04956 742729003548 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 742729003549 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 742729003550 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 742729003551 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 742729003552 DEAD/DEAH box helicase; Region: DEAD; pfam00270 742729003553 ATP binding site [chemical binding]; other site 742729003554 putative Mg++ binding site [ion binding]; other site 742729003555 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 742729003556 SEC-C motif; Region: SEC-C; pfam02810 742729003557 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 742729003558 30S subunit binding site; other site 742729003559 RecX family; Region: RecX; pfam02631 742729003560 recombinase A; Provisional; Region: recA; PRK09354 742729003561 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 742729003562 hexamer interface [polypeptide binding]; other site 742729003563 Walker A motif; other site 742729003564 ATP binding site [chemical binding]; other site 742729003565 Walker B motif; other site 742729003566 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 742729003567 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 742729003568 non-specific DNA binding site [nucleotide binding]; other site 742729003569 salt bridge; other site 742729003570 sequence-specific DNA binding site [nucleotide binding]; other site 742729003571 Competence-damaged protein; Region: CinA; pfam02464 742729003572 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 742729003573 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 742729003574 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 742729003575 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 742729003576 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 742729003577 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 742729003578 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 742729003579 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 742729003580 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 742729003581 FeS/SAM binding site; other site 742729003582 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 742729003583 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 742729003584 synthetase active site [active] 742729003585 NTP binding site [chemical binding]; other site 742729003586 metal binding site [ion binding]; metal-binding site 742729003587 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 742729003588 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 742729003589 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 742729003590 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 742729003591 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 742729003592 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 742729003593 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 742729003594 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729003595 Walker A/P-loop; other site 742729003596 ATP binding site [chemical binding]; other site 742729003597 Q-loop/lid; other site 742729003598 ABC transporter signature motif; other site 742729003599 Walker B; other site 742729003600 D-loop; other site 742729003601 H-loop/switch region; other site 742729003602 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 742729003603 Histidine kinase; Region: HisKA_3; pfam07730 742729003604 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 742729003605 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 742729003606 active site 742729003607 phosphorylation site [posttranslational modification] 742729003608 intermolecular recognition site; other site 742729003609 dimerization interface [polypeptide binding]; other site 742729003610 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 742729003611 DNA binding residues [nucleotide binding] 742729003612 dimerization interface [polypeptide binding]; other site 742729003613 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 742729003614 Transposase; Region: DDE_Tnp_ISL3; pfam01610 742729003615 Protein of unknown function DUF262; Region: DUF262; pfam03235 742729003616 Uncharacterized conserved protein [Function unknown]; Region: COG1479 742729003617 Protein of unknown function DUF262; Region: DUF262; pfam03235 742729003618 maltose O-acetyltransferase; Provisional; Region: PRK10092 742729003619 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 742729003620 active site 742729003621 substrate binding site [chemical binding]; other site 742729003622 trimer interface [polypeptide binding]; other site 742729003623 CoA binding site [chemical binding]; other site 742729003624 aconitate hydratase; Validated; Region: PRK09277 742729003625 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 742729003626 substrate binding site [chemical binding]; other site 742729003627 ligand binding site [chemical binding]; other site 742729003628 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 742729003629 substrate binding site [chemical binding]; other site 742729003630 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 742729003631 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 742729003632 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 742729003633 Soluble P-type ATPase [General function prediction only]; Region: COG4087 742729003634 Protein of unknown function (DUF418); Region: DUF418; cl12135 742729003635 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 742729003636 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 742729003637 TRAM domain; Region: TRAM; cl01282 742729003638 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 742729003639 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 742729003640 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 742729003641 putative active site [active] 742729003642 putative catalytic site [active] 742729003643 putative DNA binding site [nucleotide binding]; other site 742729003644 putative phosphate binding site [ion binding]; other site 742729003645 metal binding site A [ion binding]; metal-binding site 742729003646 putative AP binding site [nucleotide binding]; other site 742729003647 putative metal binding site B [ion binding]; other site 742729003648 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 742729003649 AAA domain; Region: AAA_21; pfam13304 742729003650 Walker A/P-loop; other site 742729003651 ATP binding site [chemical binding]; other site 742729003652 Q-loop/lid; other site 742729003653 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 742729003654 ABC transporter signature motif; other site 742729003655 Walker B; other site 742729003656 D-loop; other site 742729003657 H-loop/switch region; other site 742729003658 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 742729003659 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 742729003660 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 742729003661 Walker A/P-loop; other site 742729003662 ATP binding site [chemical binding]; other site 742729003663 Q-loop/lid; other site 742729003664 ABC transporter signature motif; other site 742729003665 Walker B; other site 742729003666 D-loop; other site 742729003667 H-loop/switch region; other site 742729003668 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 742729003669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729003670 dimer interface [polypeptide binding]; other site 742729003671 conserved gate region; other site 742729003672 putative PBP binding loops; other site 742729003673 ABC-ATPase subunit interface; other site 742729003674 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 742729003675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729003676 dimer interface [polypeptide binding]; other site 742729003677 conserved gate region; other site 742729003678 putative PBP binding loops; other site 742729003679 ABC-ATPase subunit interface; other site 742729003680 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 742729003681 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 742729003682 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 742729003683 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 742729003684 active site 742729003685 DNA binding site [nucleotide binding] 742729003686 Int/Topo IB signature motif; other site 742729003687 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 742729003688 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 742729003689 Walker A/P-loop; other site 742729003690 ATP binding site [chemical binding]; other site 742729003691 Q-loop/lid; other site 742729003692 ABC transporter signature motif; other site 742729003693 Walker B; other site 742729003694 D-loop; other site 742729003695 H-loop/switch region; other site 742729003696 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 742729003697 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 742729003698 FtsX-like permease family; Region: FtsX; pfam02687 742729003699 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 742729003700 FtsX-like permease family; Region: FtsX; pfam02687 742729003701 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 742729003702 prephenate dehydrogenase; Validated; Region: PRK08507 742729003703 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 742729003704 Prephenate dehydratase; Region: PDT; pfam00800 742729003705 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 742729003706 putative L-Phe binding site [chemical binding]; other site 742729003707 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 742729003708 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 742729003709 G1 box; other site 742729003710 putative GEF interaction site [polypeptide binding]; other site 742729003711 GTP/Mg2+ binding site [chemical binding]; other site 742729003712 Switch I region; other site 742729003713 G2 box; other site 742729003714 G3 box; other site 742729003715 Switch II region; other site 742729003716 G4 box; other site 742729003717 G5 box; other site 742729003718 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 742729003719 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 742729003720 benzoate transport; Region: 2A0115; TIGR00895 742729003721 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729003722 putative substrate translocation pore; other site 742729003723 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 742729003724 nudix motif; other site 742729003725 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 742729003726 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 742729003727 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 742729003728 P-loop; other site 742729003729 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 742729003730 Magnesium ion binding site [ion binding]; other site 742729003731 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 742729003732 Magnesium ion binding site [ion binding]; other site 742729003733 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 742729003734 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 742729003735 active site 742729003736 Int/Topo IB signature motif; other site 742729003737 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 742729003738 23S rRNA binding site [nucleotide binding]; other site 742729003739 L21 binding site [polypeptide binding]; other site 742729003740 L13 binding site [polypeptide binding]; other site 742729003741 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 742729003742 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 742729003743 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 742729003744 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 742729003745 Thiamine pyrophosphokinase; Region: TPK; cd07995 742729003746 active site 742729003747 dimerization interface [polypeptide binding]; other site 742729003748 thiamine binding site [chemical binding]; other site 742729003749 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 742729003750 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 742729003751 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 742729003752 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 742729003753 putative deacylase active site [active] 742729003754 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 742729003755 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 742729003756 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 742729003757 active site 742729003758 catalytic residues [active] 742729003759 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 742729003760 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 742729003761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 742729003762 DNA binding residues [nucleotide binding] 742729003763 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 742729003764 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 742729003765 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 742729003766 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 742729003767 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 742729003768 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 742729003769 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 742729003770 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 742729003771 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 742729003772 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 742729003773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 742729003774 active site 742729003775 phosphorylation site [posttranslational modification] 742729003776 intermolecular recognition site; other site 742729003777 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 742729003778 DNA binding residues [nucleotide binding] 742729003779 dimerization interface [polypeptide binding]; other site 742729003780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 742729003781 Histidine kinase; Region: HisKA_3; pfam07730 742729003782 proline aminopeptidase P II; Provisional; Region: PRK10879 742729003783 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 742729003784 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 742729003785 active site 742729003786 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 742729003787 nudix motif; other site 742729003788 MarR family; Region: MarR_2; cl17246 742729003789 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 742729003790 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 742729003791 nucleotide binding site [chemical binding]; other site 742729003792 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 742729003793 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 742729003794 putative substrate binding site [chemical binding]; other site 742729003795 putative ATP binding site [chemical binding]; other site 742729003796 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 742729003797 putative active site [active] 742729003798 dimerization interface [polypeptide binding]; other site 742729003799 putative tRNAtyr binding site [nucleotide binding]; other site 742729003800 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 742729003801 active site 742729003802 DNA binding site [nucleotide binding] 742729003803 Int/Topo IB signature motif; other site 742729003804 Helix-turn-helix domain; Region: HTH_17; pfam12728 742729003805 Helix-turn-helix domain; Region: HTH_17; pfam12728 742729003806 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 742729003807 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 742729003808 Walker A motif; other site 742729003809 ATP binding site [chemical binding]; other site 742729003810 Walker B motif; other site 742729003811 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 742729003812 Phage capsid family; Region: Phage_capsid; pfam05065 742729003813 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 742729003814 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 742729003815 Walker A/P-loop; other site 742729003816 ATP binding site [chemical binding]; other site 742729003817 Q-loop/lid; other site 742729003818 ABC transporter signature motif; other site 742729003819 Walker B; other site 742729003820 D-loop; other site 742729003821 H-loop/switch region; other site 742729003822 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 742729003823 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 742729003824 Walker A/P-loop; other site 742729003825 ATP binding site [chemical binding]; other site 742729003826 Q-loop/lid; other site 742729003827 ABC transporter signature motif; other site 742729003828 Walker B; other site 742729003829 D-loop; other site 742729003830 H-loop/switch region; other site 742729003831 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 742729003832 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 742729003833 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 742729003834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729003835 dimer interface [polypeptide binding]; other site 742729003836 conserved gate region; other site 742729003837 ABC-ATPase subunit interface; other site 742729003838 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 742729003839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729003840 dimer interface [polypeptide binding]; other site 742729003841 conserved gate region; other site 742729003842 putative PBP binding loops; other site 742729003843 ABC-ATPase subunit interface; other site 742729003844 potential frameshift: common BLAST hit: gi|311063978|ref|YP_003970703.1| peptide ABC transporter substrate-binding protein OppA 742729003845 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 742729003846 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 742729003847 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 742729003848 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 742729003849 cell division protein FtsQ; Provisional; Region: PRK05529 742729003850 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 742729003851 Cell division protein FtsQ; Region: FtsQ; pfam03799 742729003852 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 742729003853 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 742729003854 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 742729003855 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 742729003856 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 742729003857 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 742729003858 active site 742729003859 homodimer interface [polypeptide binding]; other site 742729003860 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 742729003861 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 742729003862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 742729003863 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 742729003864 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 742729003865 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 742729003866 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 742729003867 Mg++ binding site [ion binding]; other site 742729003868 putative catalytic motif [active] 742729003869 putative substrate binding site [chemical binding]; other site 742729003870 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 742729003871 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 742729003872 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 742729003873 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 742729003874 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 742729003875 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 742729003876 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 742729003877 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 742729003878 MraW methylase family; Region: Methyltransf_5; cl17771 742729003879 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 742729003880 MraZ protein; Region: MraZ; pfam02381 742729003881 cell division protein MraZ; Reviewed; Region: PRK00326 742729003882 MraZ protein; Region: MraZ; pfam02381 742729003883 Part of AAA domain; Region: AAA_19; pfam13245 742729003884 Family description; Region: UvrD_C_2; pfam13538 742729003885 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 742729003886 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 742729003887 ligand binding site [chemical binding]; other site 742729003888 NAD binding site [chemical binding]; other site 742729003889 tetramer interface [polypeptide binding]; other site 742729003890 catalytic site [active] 742729003891 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 742729003892 L-serine binding site [chemical binding]; other site 742729003893 ACT domain interface; other site 742729003894 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 742729003895 ATP cone domain; Region: ATP-cone; pfam03477 742729003896 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 742729003897 LexA repressor; Validated; Region: PRK00215 742729003898 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 742729003899 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 742729003900 Catalytic site [active] 742729003901 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 742729003902 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 742729003903 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 742729003904 NAD binding site [chemical binding]; other site 742729003905 dimer interface [polypeptide binding]; other site 742729003906 substrate binding site [chemical binding]; other site 742729003907 tetramer (dimer of dimers) interface [polypeptide binding]; other site 742729003908 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 742729003909 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 742729003910 HflX GTPase family; Region: HflX; cd01878 742729003911 G1 box; other site 742729003912 GTP/Mg2+ binding site [chemical binding]; other site 742729003913 Switch I region; other site 742729003914 G2 box; other site 742729003915 G3 box; other site 742729003916 Switch II region; other site 742729003917 G4 box; other site 742729003918 G5 box; other site 742729003919 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 742729003920 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 742729003921 S-adenosylmethionine binding site [chemical binding]; other site 742729003922 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 742729003923 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 742729003924 ATP binding site [chemical binding]; other site 742729003925 putative Mg++ binding site [ion binding]; other site 742729003926 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 742729003927 nucleotide binding region [chemical binding]; other site 742729003928 ATP-binding site [chemical binding]; other site 742729003929 Helicase associated domain (HA2); Region: HA2; pfam04408 742729003930 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 742729003931 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 742729003932 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 742729003933 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 742729003934 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 742729003935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 742729003936 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 742729003937 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 742729003938 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 742729003939 catalytic residues [active] 742729003940 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 742729003941 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 742729003942 putative active site [active] 742729003943 oxyanion strand; other site 742729003944 catalytic triad [active] 742729003945 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 742729003946 putative active site pocket [active] 742729003947 4-fold oligomerization interface [polypeptide binding]; other site 742729003948 metal binding residues [ion binding]; metal-binding site 742729003949 3-fold/trimer interface [polypeptide binding]; other site 742729003950 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 742729003951 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729003952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729003953 homodimer interface [polypeptide binding]; other site 742729003954 catalytic residue [active] 742729003955 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 742729003956 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 742729003957 NAD binding site [chemical binding]; other site 742729003958 dimerization interface [polypeptide binding]; other site 742729003959 product binding site; other site 742729003960 substrate binding site [chemical binding]; other site 742729003961 zinc binding site [ion binding]; other site 742729003962 catalytic residues [active] 742729003963 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 742729003964 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 742729003965 active site 742729003966 PHP Thumb interface [polypeptide binding]; other site 742729003967 metal binding site [ion binding]; metal-binding site 742729003968 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 742729003969 generic binding surface I; other site 742729003970 generic binding surface II; other site 742729003971 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 742729003972 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 742729003973 RNA binding surface [nucleotide binding]; other site 742729003974 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 742729003975 active site 742729003976 lipoprotein signal peptidase; Provisional; Region: PRK14771 742729003977 DivIVA protein; Region: DivIVA; pfam05103 742729003978 DivIVA domain; Region: DivI1A_domain; TIGR03544 742729003979 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 742729003980 YGGT family; Region: YGGT; pfam02325 742729003981 Protein of unknown function (DUF552); Region: DUF552; pfam04472 742729003982 cell division protein FtsZ; Validated; Region: PRK09330 742729003983 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 742729003984 nucleotide binding site [chemical binding]; other site 742729003985 SulA interaction site; other site 742729003986 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 742729003987 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 742729003988 FMN binding site [chemical binding]; other site 742729003989 active site 742729003990 catalytic residues [active] 742729003991 substrate binding site [chemical binding]; other site 742729003992 glycyl-tRNA synthetase; Provisional; Region: PRK04173 742729003993 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 742729003994 motif 1; other site 742729003995 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 742729003996 active site 742729003997 motif 2; other site 742729003998 motif 3; other site 742729003999 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 742729004000 anticodon binding site; other site 742729004001 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 742729004002 substrate binding site [chemical binding]; other site 742729004003 multimerization interface [polypeptide binding]; other site 742729004004 ATP binding site [chemical binding]; other site 742729004005 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 742729004006 thiamine phosphate binding site [chemical binding]; other site 742729004007 active site 742729004008 pyrophosphate binding site [ion binding]; other site 742729004009 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 742729004010 substrate binding site [chemical binding]; other site 742729004011 dimer interface [polypeptide binding]; other site 742729004012 ATP binding site [chemical binding]; other site 742729004013 Domain of unknown function DUF77; Region: DUF77; pfam01910 742729004014 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729004015 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729004016 DNA binding site [nucleotide binding] 742729004017 domain linker motif; other site 742729004018 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 742729004019 putative dimerization interface [polypeptide binding]; other site 742729004020 putative ligand binding site [chemical binding]; other site 742729004021 galactoside permease; Reviewed; Region: lacY; PRK09528 742729004022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729004023 putative substrate translocation pore; other site 742729004024 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 742729004025 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 742729004026 substrate binding [chemical binding]; other site 742729004027 active site 742729004028 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 742729004029 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 742729004030 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729004031 dimer interface [polypeptide binding]; other site 742729004032 conserved gate region; other site 742729004033 putative PBP binding loops; other site 742729004034 ABC-ATPase subunit interface; other site 742729004035 NMT1/THI5 like; Region: NMT1; pfam09084 742729004036 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 742729004037 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 742729004038 active site 742729004039 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 742729004040 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 742729004041 catalytic residue [active] 742729004042 putative FPP diphosphate binding site; other site 742729004043 putative FPP binding hydrophobic cleft; other site 742729004044 dimer interface [polypeptide binding]; other site 742729004045 putative IPP diphosphate binding site; other site 742729004046 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 742729004047 Recombination protein O N terminal; Region: RecO_N; pfam11967 742729004048 Recombination protein O C terminal; Region: RecO_C; pfam02565 742729004049 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 742729004050 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 742729004051 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 742729004052 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 742729004053 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 742729004054 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 742729004055 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 742729004056 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 742729004057 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 742729004058 DivIVA domain; Region: DivI1A_domain; TIGR03544 742729004059 DivIVA domain; Region: DivI1A_domain; TIGR03544 742729004060 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 742729004061 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 742729004062 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 742729004063 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 742729004064 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 742729004065 Part of AAA domain; Region: AAA_19; pfam13245 742729004066 Family description; Region: UvrD_C_2; pfam13538 742729004067 Phosphotransferase enzyme family; Region: APH; pfam01636 742729004068 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 742729004069 substrate binding site [chemical binding]; other site 742729004070 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 742729004071 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 742729004072 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 742729004073 active site 742729004074 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 742729004075 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 742729004076 putative active site [active] 742729004077 redox center [active] 742729004078 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 742729004079 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 742729004080 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 742729004081 glutamate racemase; Provisional; Region: PRK00865 742729004082 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 742729004083 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 742729004084 active site 742729004085 nucleophile elbow; other site 742729004086 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 742729004087 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 742729004088 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 742729004089 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 742729004090 substrate binding pocket [chemical binding]; other site 742729004091 membrane-bound complex binding site; other site 742729004092 hinge residues; other site 742729004093 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 742729004094 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729004095 Walker A/P-loop; other site 742729004096 ATP binding site [chemical binding]; other site 742729004097 Q-loop/lid; other site 742729004098 ABC transporter signature motif; other site 742729004099 Walker B; other site 742729004100 D-loop; other site 742729004101 H-loop/switch region; other site 742729004102 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 742729004103 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729004104 dimer interface [polypeptide binding]; other site 742729004105 conserved gate region; other site 742729004106 putative PBP binding loops; other site 742729004107 ABC-ATPase subunit interface; other site 742729004108 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 742729004109 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729004110 dimer interface [polypeptide binding]; other site 742729004111 conserved gate region; other site 742729004112 putative PBP binding loops; other site 742729004113 ABC-ATPase subunit interface; other site 742729004114 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 742729004115 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729004116 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729004117 homodimer interface [polypeptide binding]; other site 742729004118 catalytic residue [active] 742729004119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729004120 putative PBP binding loops; other site 742729004121 ABC-ATPase subunit interface; other site 742729004122 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 742729004123 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 742729004124 Walker A/P-loop; other site 742729004125 ATP binding site [chemical binding]; other site 742729004126 Q-loop/lid; other site 742729004127 ABC transporter signature motif; other site 742729004128 Walker B; other site 742729004129 D-loop; other site 742729004130 H-loop/switch region; other site 742729004131 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 742729004132 NIL domain; Region: NIL; pfam09383 742729004133 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 742729004134 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 742729004135 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 742729004136 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 742729004137 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 742729004138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 742729004139 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 742729004140 active site 742729004141 catalytic site [active] 742729004142 substrate binding site [chemical binding]; other site 742729004143 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 742729004144 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 742729004145 G1 box; other site 742729004146 putative GEF interaction site [polypeptide binding]; other site 742729004147 GTP/Mg2+ binding site [chemical binding]; other site 742729004148 Switch I region; other site 742729004149 G2 box; other site 742729004150 G3 box; other site 742729004151 Switch II region; other site 742729004152 G4 box; other site 742729004153 G5 box; other site 742729004154 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 742729004155 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 742729004156 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 742729004157 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 742729004158 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 742729004159 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 742729004160 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729004161 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729004162 putative substrate translocation pore; other site 742729004163 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 742729004164 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 742729004165 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 742729004166 HIGH motif; other site 742729004167 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 742729004168 active site 742729004169 KMSKS motif; other site 742729004170 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 742729004171 tRNA binding surface [nucleotide binding]; other site 742729004172 anticodon binding site; other site 742729004173 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 742729004174 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 742729004175 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 742729004176 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 742729004177 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 742729004178 Walker A/P-loop; other site 742729004179 ATP binding site [chemical binding]; other site 742729004180 Q-loop/lid; other site 742729004181 ABC transporter signature motif; other site 742729004182 Walker B; other site 742729004183 D-loop; other site 742729004184 H-loop/switch region; other site 742729004185 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 742729004186 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 742729004187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729004188 Walker A/P-loop; other site 742729004189 ATP binding site [chemical binding]; other site 742729004190 Q-loop/lid; other site 742729004191 ABC transporter signature motif; other site 742729004192 Walker B; other site 742729004193 D-loop; other site 742729004194 H-loop/switch region; other site 742729004195 MarR family; Region: MarR_2; pfam12802 742729004196 Transcriptional regulators [Transcription]; Region: MarR; COG1846 742729004197 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 742729004198 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 742729004199 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 742729004200 mismatch recognition site; other site 742729004201 additional DNA contacts [nucleotide binding]; other site 742729004202 active site 742729004203 zinc binding site [ion binding]; other site 742729004204 DNA intercalation site [nucleotide binding]; other site 742729004205 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 742729004206 FIC domain binding interface [polypeptide binding]; other site 742729004207 Fic/DOC family; Region: Fic; cl00960 742729004208 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 742729004209 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 742729004210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 742729004211 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 742729004212 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 742729004213 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 742729004214 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 742729004215 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 742729004216 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 742729004217 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 742729004218 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 742729004219 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 742729004220 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 742729004221 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 742729004222 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 742729004223 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 742729004224 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 742729004225 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 742729004226 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 742729004227 FeS/SAM binding site; other site 742729004228 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 742729004229 ATP cone domain; Region: ATP-cone; pfam03477 742729004230 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 742729004231 Class III ribonucleotide reductase; Region: RNR_III; cd01675 742729004232 active site 742729004233 Zn binding site [ion binding]; other site 742729004234 glycine loop; other site 742729004235 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 742729004236 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 742729004237 generic binding surface II; other site 742729004238 generic binding surface I; other site 742729004239 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 742729004240 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 742729004241 putative catalytic site [active] 742729004242 putative metal binding site [ion binding]; other site 742729004243 putative phosphate binding site [ion binding]; other site 742729004244 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 742729004245 aminotransferase; Validated; Region: PRK07337 742729004246 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 742729004247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729004248 homodimer interface [polypeptide binding]; other site 742729004249 catalytic residue [active] 742729004250 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 742729004251 additional DNA contacts [nucleotide binding]; other site 742729004252 mismatch recognition site; other site 742729004253 active site 742729004254 zinc binding site [ion binding]; other site 742729004255 DNA intercalation site [nucleotide binding]; other site 742729004256 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 742729004257 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 742729004258 active site 742729004259 catalytic site [active] 742729004260 substrate binding site [chemical binding]; other site 742729004261 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 742729004262 active site 742729004263 catalytic residues [active] 742729004264 metal binding site [ion binding]; metal-binding site 742729004265 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 742729004266 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 742729004267 active site 742729004268 substrate binding site [chemical binding]; other site 742729004269 metal binding site [ion binding]; metal-binding site 742729004270 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 742729004271 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 742729004272 Zn binding site [ion binding]; other site 742729004273 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 742729004274 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 742729004275 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 742729004276 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 742729004277 dihydrodipicolinate synthase; Region: dapA; TIGR00674 742729004278 dimer interface [polypeptide binding]; other site 742729004279 active site 742729004280 catalytic residue [active] 742729004281 dihydrodipicolinate reductase; Provisional; Region: PRK00048 742729004282 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 742729004283 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 742729004284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729004285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729004286 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 742729004287 Coenzyme A binding pocket [chemical binding]; other site 742729004288 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 742729004289 Family description; Region: UvrD_C_2; pfam13538 742729004290 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 742729004291 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 742729004292 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 742729004293 Catalytic domain of Protein Kinases; Region: PKc; cd00180 742729004294 active site 742729004295 ATP binding site [chemical binding]; other site 742729004296 substrate binding site [chemical binding]; other site 742729004297 activation loop (A-loop); other site 742729004298 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 742729004299 Interdomain contacts; other site 742729004300 Cytokine receptor motif; other site 742729004301 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 742729004302 Interdomain contacts; other site 742729004303 Cytokine receptor motif; other site 742729004304 MoxR-like ATPases [General function prediction only]; Region: COG0714 742729004305 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729004306 Walker A motif; other site 742729004307 ATP binding site [chemical binding]; other site 742729004308 Walker B motif; other site 742729004309 arginine finger; other site 742729004310 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 742729004311 Protein of unknown function DUF58; Region: DUF58; pfam01882 742729004312 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 742729004313 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 742729004314 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 742729004315 phosphopeptide binding site; other site 742729004316 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 742729004317 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 742729004318 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 742729004319 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 742729004320 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 742729004321 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 742729004322 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 742729004323 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 742729004324 DNA binding site [nucleotide binding] 742729004325 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 742729004326 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 742729004327 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 742729004328 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 742729004329 RPB1 interaction site [polypeptide binding]; other site 742729004330 RPB10 interaction site [polypeptide binding]; other site 742729004331 RPB11 interaction site [polypeptide binding]; other site 742729004332 RPB3 interaction site [polypeptide binding]; other site 742729004333 RPB12 interaction site [polypeptide binding]; other site 742729004334 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 742729004335 endonuclease III; Region: ENDO3c; smart00478 742729004336 minor groove reading motif; other site 742729004337 helix-hairpin-helix signature motif; other site 742729004338 substrate binding pocket [chemical binding]; other site 742729004339 active site 742729004340 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 742729004341 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 742729004342 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 742729004343 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 742729004344 active site 742729004345 catalytic site [active] 742729004346 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 742729004347 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 742729004348 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 742729004349 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 742729004350 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 742729004351 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 742729004352 dimer interface [polypeptide binding]; other site 742729004353 active site 742729004354 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 742729004355 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 742729004356 DNA-binding site [nucleotide binding]; DNA binding site 742729004357 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 742729004358 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 742729004359 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 742729004360 Ligand binding site; other site 742729004361 Putative Catalytic site; other site 742729004362 DXD motif; other site 742729004363 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 742729004364 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 742729004365 quinone interaction residues [chemical binding]; other site 742729004366 active site 742729004367 catalytic residues [active] 742729004368 FMN binding site [chemical binding]; other site 742729004369 substrate binding site [chemical binding]; other site 742729004370 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 742729004371 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 742729004372 active site 742729004373 FMN binding site [chemical binding]; other site 742729004374 substrate binding site [chemical binding]; other site 742729004375 homotetramer interface [polypeptide binding]; other site 742729004376 catalytic residue [active] 742729004377 Transglycosylase; Region: Transgly; pfam00912 742729004378 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 742729004379 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 742729004380 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 742729004381 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 742729004382 ligand binding site [chemical binding]; other site 742729004383 flexible hinge region; other site 742729004384 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 742729004385 putative switch regulator; other site 742729004386 non-specific DNA interactions [nucleotide binding]; other site 742729004387 DNA binding site [nucleotide binding] 742729004388 sequence specific DNA binding site [nucleotide binding]; other site 742729004389 putative cAMP binding site [chemical binding]; other site 742729004390 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 742729004391 TM2 domain; Region: TM2; pfam05154 742729004392 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 742729004393 tartrate dehydrogenase; Region: TTC; TIGR02089 742729004394 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 742729004395 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 742729004396 Uncharacterized conserved protein [Function unknown]; Region: COG4850 742729004397 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 742729004398 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 742729004399 lipoyl attachment site [posttranslational modification]; other site 742729004400 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 742729004401 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 742729004402 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 742729004403 putative NADH binding site [chemical binding]; other site 742729004404 putative active site [active] 742729004405 nudix motif; other site 742729004406 putative metal binding site [ion binding]; other site 742729004407 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 742729004408 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 742729004409 nudix motif; other site 742729004410 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 742729004411 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 742729004412 catalytic residues [active] 742729004413 Domain of unknown function (DUF348); Region: DUF348; pfam03990 742729004414 G5 domain; Region: G5; pfam07501 742729004415 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 742729004416 N-acetyl-D-glucosamine binding site [chemical binding]; other site 742729004417 catalytic residue [active] 742729004418 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 742729004419 Bacterial sugar transferase; Region: Bac_transf; pfam02397 742729004420 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 742729004421 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 742729004422 Putative Catalytic site; other site 742729004423 DXD motif; other site 742729004424 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 742729004425 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 742729004426 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 742729004427 substrate binding site; other site 742729004428 tetramer interface; other site 742729004429 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 742729004430 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 742729004431 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 742729004432 NADP binding site [chemical binding]; other site 742729004433 active site 742729004434 putative substrate binding site [chemical binding]; other site 742729004435 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 742729004436 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 742729004437 NAD binding site [chemical binding]; other site 742729004438 substrate binding site [chemical binding]; other site 742729004439 homodimer interface [polypeptide binding]; other site 742729004440 active site 742729004441 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 742729004442 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 742729004443 Probable Catalytic site; other site 742729004444 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 742729004445 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 742729004446 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 742729004447 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 742729004448 active site 742729004449 putative glycosyl transferase; Provisional; Region: PRK10073 742729004450 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 742729004451 active site 742729004452 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 742729004453 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 742729004454 active site 742729004455 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 742729004456 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 742729004457 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 742729004458 active site 742729004459 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 742729004460 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 742729004461 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 742729004462 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 742729004463 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 742729004464 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 742729004465 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 742729004466 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 742729004467 Bacterial sugar transferase; Region: Bac_transf; pfam02397 742729004468 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729004469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729004470 putative substrate translocation pore; other site 742729004471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729004472 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 742729004473 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 742729004474 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 742729004475 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 742729004476 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 742729004477 active site 742729004478 multimer interface [polypeptide binding]; other site 742729004479 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 742729004480 predicted active site [active] 742729004481 catalytic triad [active] 742729004482 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 742729004483 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 742729004484 putative NAD(P) binding site [chemical binding]; other site 742729004485 active site 742729004486 putative substrate binding site [chemical binding]; other site 742729004487 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 742729004488 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 742729004489 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729004490 Walker A/P-loop; other site 742729004491 ATP binding site [chemical binding]; other site 742729004492 Q-loop/lid; other site 742729004493 ABC transporter signature motif; other site 742729004494 Walker B; other site 742729004495 D-loop; other site 742729004496 H-loop/switch region; other site 742729004497 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 742729004498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729004499 Walker A/P-loop; other site 742729004500 ATP binding site [chemical binding]; other site 742729004501 Q-loop/lid; other site 742729004502 ABC transporter signature motif; other site 742729004503 Walker B; other site 742729004504 D-loop; other site 742729004505 H-loop/switch region; other site 742729004506 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 742729004507 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 742729004508 acyl-activating enzyme (AAE) consensus motif; other site 742729004509 putative AMP binding site [chemical binding]; other site 742729004510 putative active site [active] 742729004511 putative CoA binding site [chemical binding]; other site 742729004512 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 742729004513 putative active site [active] 742729004514 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 742729004515 dimer interface [polypeptide binding]; other site 742729004516 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 742729004517 nudix motif; other site 742729004518 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 742729004519 Low molecular weight phosphatase family; Region: LMWPc; cd00115 742729004520 active site 742729004521 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 742729004522 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 742729004523 Chain length determinant protein; Region: Wzz; cl15801 742729004524 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 742729004525 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 742729004526 Nucleotide binding site [chemical binding]; other site 742729004527 DTAP/Switch II; other site 742729004528 Switch I; other site 742729004529 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 742729004530 Transposase; Region: DDE_Tnp_ISL3; pfam01610 742729004531 homoserine kinase; Provisional; Region: PRK01212 742729004532 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 742729004533 homoserine dehydrogenase; Provisional; Region: PRK06349 742729004534 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 742729004535 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 742729004536 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 742729004537 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 742729004538 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 742729004539 catalytic residue [active] 742729004540 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 742729004541 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 742729004542 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 742729004543 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 742729004544 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 742729004545 active site 742729004546 HIGH motif; other site 742729004547 KMSK motif region; other site 742729004548 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 742729004549 tRNA binding surface [nucleotide binding]; other site 742729004550 anticodon binding site; other site 742729004551 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 742729004552 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 742729004553 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 742729004554 homotrimer interaction site [polypeptide binding]; other site 742729004555 putative active site [active] 742729004556 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 742729004557 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729004558 dimer interface [polypeptide binding]; other site 742729004559 conserved gate region; other site 742729004560 putative PBP binding loops; other site 742729004561 ABC-ATPase subunit interface; other site 742729004562 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 742729004563 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 742729004564 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 742729004565 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 742729004566 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 742729004567 hypothetical protein; Provisional; Region: PRK03298 742729004568 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 742729004569 gamma subunit interface [polypeptide binding]; other site 742729004570 epsilon subunit interface [polypeptide binding]; other site 742729004571 LBP interface [polypeptide binding]; other site 742729004572 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 742729004573 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 742729004574 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 742729004575 alpha subunit interaction interface [polypeptide binding]; other site 742729004576 Walker A motif; other site 742729004577 ATP binding site [chemical binding]; other site 742729004578 Walker B motif; other site 742729004579 inhibitor binding site; inhibition site 742729004580 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 742729004581 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 742729004582 core domain interface [polypeptide binding]; other site 742729004583 delta subunit interface [polypeptide binding]; other site 742729004584 epsilon subunit interface [polypeptide binding]; other site 742729004585 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 742729004586 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 742729004587 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 742729004588 beta subunit interaction interface [polypeptide binding]; other site 742729004589 Walker A motif; other site 742729004590 ATP binding site [chemical binding]; other site 742729004591 Walker B motif; other site 742729004592 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 742729004593 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 742729004594 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 742729004595 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 742729004596 ATP synthase subunit C; Region: ATP-synt_C; cl00466 742729004597 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 742729004598 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 742729004599 homoserine O-succinyltransferase; Provisional; Region: PRK05368 742729004600 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 742729004601 proposed active site lysine [active] 742729004602 conserved cys residue [active] 742729004603 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729004604 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729004605 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 742729004606 active site 742729004607 tetramer interface [polypeptide binding]; other site 742729004608 Protein of unknown function DUF262; Region: DUF262; pfam03235 742729004609 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 742729004610 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 742729004611 active site 742729004612 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 742729004613 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 742729004614 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 742729004615 Int/Topo IB signature motif; other site 742729004616 formyl-coenzyme A transferase; Provisional; Region: PRK05398 742729004617 CoA-transferase family III; Region: CoA_transf_3; pfam02515 742729004618 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 742729004619 Cellulose or protein binding domain; Region: CBM_10; pfam02013 742729004620 Membrane transport protein; Region: Mem_trans; cl09117 742729004621 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 742729004622 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 742729004623 PYR/PP interface [polypeptide binding]; other site 742729004624 dimer interface [polypeptide binding]; other site 742729004625 TPP binding site [chemical binding]; other site 742729004626 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 742729004627 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 742729004628 TPP-binding site; other site 742729004629 dimer interface [polypeptide binding]; other site 742729004630 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 742729004631 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 742729004632 Cl- selectivity filter; other site 742729004633 Cl- binding residues [ion binding]; other site 742729004634 pore gating glutamate residue; other site 742729004635 dimer interface [polypeptide binding]; other site 742729004636 TQXA domain; Region: TQXA_dom; TIGR03934 742729004637 Cna protein B-type domain; Region: Cna_B; pfam05738 742729004638 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 742729004639 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 742729004640 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 742729004641 active site 742729004642 catalytic site [active] 742729004643 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 742729004644 dimer interface [polypeptide binding]; other site 742729004645 substrate binding site [chemical binding]; other site 742729004646 metal binding sites [ion binding]; metal-binding site 742729004647 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 742729004648 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 742729004649 DNA binding site [nucleotide binding] 742729004650 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 742729004651 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 742729004652 minor groove reading motif; other site 742729004653 helix-hairpin-helix signature motif; other site 742729004654 substrate binding pocket [chemical binding]; other site 742729004655 active site 742729004656 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 742729004657 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 742729004658 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 742729004659 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 742729004660 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 742729004661 active site 742729004662 HIGH motif; other site 742729004663 nucleotide binding site [chemical binding]; other site 742729004664 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 742729004665 active site 742729004666 KMSKS motif; other site 742729004667 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 742729004668 tRNA binding surface [nucleotide binding]; other site 742729004669 anticodon binding site; other site 742729004670 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 742729004671 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 742729004672 dimerization interface [polypeptide binding]; other site 742729004673 putative Zn2+ binding site [ion binding]; other site 742729004674 putative DNA binding site [nucleotide binding]; other site 742729004675 chorismate mutase; Provisional; Region: PRK09239 742729004676 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 742729004677 transcription termination factor Rho; Provisional; Region: PRK12608 742729004678 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 742729004679 RNA binding site [nucleotide binding]; other site 742729004680 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 742729004681 Walker A motif; other site 742729004682 ATP binding site [chemical binding]; other site 742729004683 Walker B motif; other site 742729004684 hypothetical protein; Provisional; Region: PRK07208 742729004685 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 742729004686 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 742729004687 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 742729004688 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 742729004689 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 742729004690 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 742729004691 GatB domain; Region: GatB_Yqey; pfam02637 742729004692 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 742729004693 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 742729004694 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 742729004695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729004696 ABC transporter signature motif; other site 742729004697 Walker B; other site 742729004698 D-loop; other site 742729004699 H-loop/switch region; other site 742729004700 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 742729004701 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 742729004702 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 742729004703 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 742729004704 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 742729004705 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 742729004706 Clp amino terminal domain; Region: Clp_N; pfam02861 742729004707 Clp amino terminal domain; Region: Clp_N; pfam02861 742729004708 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729004709 Walker A motif; other site 742729004710 ATP binding site [chemical binding]; other site 742729004711 Walker B motif; other site 742729004712 arginine finger; other site 742729004713 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 742729004714 Walker A motif; other site 742729004715 ATP binding site [chemical binding]; other site 742729004716 Walker B motif; other site 742729004717 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 742729004718 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 742729004719 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 742729004720 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 742729004721 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 742729004722 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 742729004723 metal ion-dependent adhesion site (MIDAS); other site 742729004724 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 742729004725 active site 742729004726 catalytic site [active] 742729004727 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 742729004728 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 742729004729 catalytic residue [active] 742729004730 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 742729004731 active site 742729004732 HIGH motif; other site 742729004733 nucleotide binding site [chemical binding]; other site 742729004734 active site 742729004735 KMSKS motif; other site 742729004736 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 742729004737 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 742729004738 amphipathic channel; other site 742729004739 Asn-Pro-Ala signature motifs; other site 742729004740 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 742729004741 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 742729004742 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 742729004743 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 742729004744 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 742729004745 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 742729004746 dimer interface [polypeptide binding]; other site 742729004747 ssDNA binding site [nucleotide binding]; other site 742729004748 tetramer (dimer of dimers) interface [polypeptide binding]; other site 742729004749 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 742729004750 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 742729004751 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 742729004752 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 742729004753 active site 742729004754 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 742729004755 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 742729004756 substrate binding site [chemical binding]; other site 742729004757 dimer interface [polypeptide binding]; other site 742729004758 ATP binding site [chemical binding]; other site 742729004759 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 742729004760 Major Facilitator Superfamily; Region: MFS_1; pfam07690 742729004761 putative substrate translocation pore; other site 742729004762 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 742729004763 active site 742729004764 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729004765 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729004766 DNA binding site [nucleotide binding] 742729004767 domain linker motif; other site 742729004768 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 742729004769 dimerization interface [polypeptide binding]; other site 742729004770 ligand binding site [chemical binding]; other site 742729004771 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 742729004772 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 742729004773 UDP-galactopyranose mutase; Region: GLF; pfam03275 742729004774 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 742729004775 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 742729004776 active site 742729004777 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 742729004778 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 742729004779 active site 742729004780 Sulfatase; Region: Sulfatase; pfam00884 742729004781 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 742729004782 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 742729004783 active site 742729004784 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 742729004785 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 742729004786 active site 742729004787 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 742729004788 active site 742729004789 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 742729004790 S-layer homology domain; Region: SLH; pfam00395 742729004791 S-layer homology domain; Region: SLH; pfam00395 742729004792 S-layer homology domain; Region: SLH; pfam00395 742729004793 MULE transposase domain; Region: MULE; pfam10551 742729004794 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 742729004795 Leucine rich repeat; Region: LRR_8; pfam13855 742729004796 S-layer homology domain; Region: SLH; pfam00395 742729004797 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 742729004798 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 742729004799 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 742729004800 Walker A/P-loop; other site 742729004801 ATP binding site [chemical binding]; other site 742729004802 Q-loop/lid; other site 742729004803 ABC transporter signature motif; other site 742729004804 Walker B; other site 742729004805 D-loop; other site 742729004806 H-loop/switch region; other site 742729004807 ABC-2 type transporter; Region: ABC2_membrane; cl17235 742729004808 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 742729004809 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 742729004810 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 742729004811 active site 742729004812 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 742729004813 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 742729004814 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 742729004815 FtsX-like permease family; Region: FtsX; pfam02687 742729004816 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 742729004817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729004818 ATP binding site [chemical binding]; other site 742729004819 Q-loop/lid; other site 742729004820 ABC transporter signature motif; other site 742729004821 Walker B; other site 742729004822 D-loop; other site 742729004823 H-loop/switch region; other site 742729004824 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 742729004825 Zn2+ binding site [ion binding]; other site 742729004826 Mg2+ binding site [ion binding]; other site 742729004827 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 742729004828 putative active site [active] 742729004829 putative dimer interface [polypeptide binding]; other site 742729004830 YL1 nuclear protein; Region: YL1; pfam05764 742729004831 K+ potassium transporter; Region: K_trans; pfam02705 742729004832 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 742729004833 active site 742729004834 Melibiase; Region: Melibiase; pfam02065 742729004835 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 742729004836 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 742729004837 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 742729004838 Walker A/P-loop; other site 742729004839 ATP binding site [chemical binding]; other site 742729004840 Q-loop/lid; other site 742729004841 ABC transporter signature motif; other site 742729004842 Walker B; other site 742729004843 D-loop; other site 742729004844 H-loop/switch region; other site 742729004845 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 742729004846 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 742729004847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 742729004848 Walker A/P-loop; other site 742729004849 ATP binding site [chemical binding]; other site 742729004850 Q-loop/lid; other site 742729004851 ABC transporter signature motif; other site 742729004852 Walker B; other site 742729004853 D-loop; other site 742729004854 H-loop/switch region; other site 742729004855 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 742729004856 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 742729004857 active site 742729004858 HIGH motif; other site 742729004859 KMSKS motif; other site 742729004860 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 742729004861 tRNA binding surface [nucleotide binding]; other site 742729004862 anticodon binding site; other site 742729004863 Predicted methyltransferases [General function prediction only]; Region: COG0313 742729004864 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 742729004865 putative SAM binding site [chemical binding]; other site 742729004866 putative homodimer interface [polypeptide binding]; other site 742729004867 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 742729004868 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 742729004869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 742729004870 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 742729004871 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 742729004872 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 742729004873 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 742729004874 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 742729004875 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 742729004876 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 742729004877 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 742729004878 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 742729004879 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 742729004880 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729004881 motif II; other site 742729004882 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 742729004883 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 742729004884 DNA binding residues [nucleotide binding] 742729004885 putative dimer interface [polypeptide binding]; other site 742729004886 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 742729004887 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 742729004888 HSP70 interaction site [polypeptide binding]; other site 742729004889 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 742729004890 substrate binding site [polypeptide binding]; other site 742729004891 dimer interface [polypeptide binding]; other site 742729004892 GrpE; Region: GrpE; pfam01025 742729004893 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 742729004894 dimer interface [polypeptide binding]; other site 742729004895 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 742729004896 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 742729004897 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 742729004898 nucleotide binding site [chemical binding]; other site 742729004899 NEF interaction site [polypeptide binding]; other site 742729004900 SBD interface [polypeptide binding]; other site 742729004901 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729004902 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729004903 DNA binding site [nucleotide binding] 742729004904 domain linker motif; other site 742729004905 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 742729004906 ligand binding site [chemical binding]; other site 742729004907 dimerization interface [polypeptide binding]; other site 742729004908 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 742729004909 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729004910 motif II; other site 742729004911 pullulanase, type I; Region: pulA_typeI; TIGR02104 742729004912 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 742729004913 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 742729004914 Ca binding site [ion binding]; other site 742729004915 active site 742729004916 catalytic site [active] 742729004917 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 742729004918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729004919 dimer interface [polypeptide binding]; other site 742729004920 conserved gate region; other site 742729004921 putative PBP binding loops; other site 742729004922 ABC-ATPase subunit interface; other site 742729004923 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 742729004924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729004925 dimer interface [polypeptide binding]; other site 742729004926 conserved gate region; other site 742729004927 putative PBP binding loops; other site 742729004928 ABC-ATPase subunit interface; other site 742729004929 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 742729004930 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 742729004931 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 742729004932 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 742729004933 active site 742729004934 catalytic site [active] 742729004935 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 742729004936 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 742729004937 Protein of unknown function, DUF624; Region: DUF624; pfam04854 742729004938 Protein of unknown function, DUF624; Region: DUF624; cl02369 742729004939 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 742729004940 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729004941 dimer interface [polypeptide binding]; other site 742729004942 conserved gate region; other site 742729004943 putative PBP binding loops; other site 742729004944 ABC-ATPase subunit interface; other site 742729004945 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 742729004946 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729004947 dimer interface [polypeptide binding]; other site 742729004948 conserved gate region; other site 742729004949 putative PBP binding loops; other site 742729004950 ABC-ATPase subunit interface; other site 742729004951 Transcriptional regulators [Transcription]; Region: PurR; COG1609 742729004952 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 742729004953 DNA binding site [nucleotide binding] 742729004954 domain linker motif; other site 742729004955 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 742729004956 ligand binding site [chemical binding]; other site 742729004957 dimerization interface [polypeptide binding]; other site 742729004958 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 742729004959 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 742729004960 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 742729004961 active site 742729004962 catalytic site [active] 742729004963 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 742729004964 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 742729004965 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 742729004966 dimer interface [polypeptide binding]; other site 742729004967 FMN binding site [chemical binding]; other site 742729004968 NADPH bind site [chemical binding]; other site 742729004969 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 742729004970 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 742729004971 active site 742729004972 catalytic triad [active] 742729004973 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 742729004974 RelB antitoxin; Region: RelB; cl01171 742729004975 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 742729004976 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 742729004977 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 742729004978 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 742729004979 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 742729004980 dimerization interface [polypeptide binding]; other site 742729004981 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 742729004982 ligand binding site [chemical binding]; other site 742729004983 NAD-dependent deacetylase; Provisional; Region: PRK00481 742729004984 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 742729004985 threonine dehydratase; Provisional; Region: PRK08198 742729004986 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 742729004987 tetramer interface [polypeptide binding]; other site 742729004988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 742729004989 catalytic residue [active] 742729004990 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 742729004991 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 742729004992 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 742729004993 Ca binding site [ion binding]; other site 742729004994 active site 742729004995 catalytic site [active] 742729004996 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 742729004997 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; pfam05691 742729004998 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 742729004999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729005000 dimer interface [polypeptide binding]; other site 742729005001 conserved gate region; other site 742729005002 putative PBP binding loops; other site 742729005003 ABC-ATPase subunit interface; other site 742729005004 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 742729005005 dimer interface [polypeptide binding]; other site 742729005006 conserved gate region; other site 742729005007 putative PBP binding loops; other site 742729005008 ABC-ATPase subunit interface; other site 742729005009 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 742729005010 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 742729005011 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 742729005012 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 742729005013 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 742729005014 Melibiase; Region: Melibiase; pfam02065 742729005015 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 742729005016 nucleoside/Zn binding site; other site 742729005017 dimer interface [polypeptide binding]; other site 742729005018 catalytic motif [active] 742729005019 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 742729005020 Predicted esterase [General function prediction only]; Region: COG0400 742729005021 Serine hydrolase (FSH1); Region: FSH1; pfam03959 742729005022 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 742729005023 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 742729005024 trimer interface [polypeptide binding]; other site 742729005025 active site 742729005026 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 742729005027 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 742729005028 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 742729005029 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 742729005030 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 742729005031 motif II; other site 742729005032 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 742729005033 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 742729005034 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 742729005035 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 742729005036 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 742729005037 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 742729005038 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 742729005039 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 742729005040 Walker A/P-loop; other site 742729005041 ATP binding site [chemical binding]; other site 742729005042 Q-loop/lid; other site 742729005043 ABC transporter signature motif; other site 742729005044 Walker B; other site 742729005045 D-loop; other site 742729005046 H-loop/switch region; other site 742729005047 TOBE domain; Region: TOBE_2; pfam08402 742729005048 Ion channel; Region: Ion_trans_2; pfam07885 742729005049 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 742729005050 Catalytic domain of Protein Kinases; Region: PKc; cd00180 742729005051 active site 742729005052 ATP binding site [chemical binding]; other site 742729005053 substrate binding site [chemical binding]; other site 742729005054 activation loop (A-loop); other site 742729005055 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 742729005056 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 742729005057 Domain of unknown function (DUF348); Region: DUF348; pfam03990 742729005058 G5 domain; Region: G5; pfam07501 742729005059 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 742729005060 N-acetyl-D-glucosamine binding site [chemical binding]; other site 742729005061 catalytic residue [active] 742729005062 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 742729005063 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 742729005064 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 742729005065 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 742729005066 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 742729005067 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 742729005068 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 742729005069 active site 742729005070 NTP binding site [chemical binding]; other site 742729005071 metal binding triad [ion binding]; metal-binding site 742729005072 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 742729005073 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 742729005074 Zn2+ binding site [ion binding]; other site 742729005075 Mg2+ binding site [ion binding]; other site 742729005076 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 742729005077 active site 742729005078 Ap6A binding site [chemical binding]; other site 742729005079 nudix motif; other site 742729005080 metal binding site [ion binding]; metal-binding site 742729005081 integral membrane protein MviN; Region: mviN; TIGR01695 742729005082 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 742729005083 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 742729005084 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 742729005085 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 742729005086 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 742729005087 ParB-like nuclease domain; Region: ParB; smart00470 742729005088 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 742729005089 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 742729005090 P-loop; other site 742729005091 Magnesium ion binding site [ion binding]; other site 742729005092 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 742729005093 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 742729005094 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 742729005095 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 742729005096 G-X-X-G motif; other site 742729005097 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 742729005098 RxxxH motif; other site 742729005099 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 742729005100 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 742729005101 IncFII RepA protein family; Region: IncFII_repA; cl11495 742729005102 hypothetical protein; Provisional; Region: PRK14372 742729005103 Ribonuclease P; Region: Ribonuclease_P; pfam00825 742729005104 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399