-- dump date   	20140619_002024
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_002967461.1	COG0593 ATPase involved in DNA replication initiation
YP_002967462.1	binds the polymerase to DNA and acts as a sliding clamp
YP_002967463.1	COG1195 Recombinational DNA repair ATPase (RecF pathway)
YP_002967464.1	COG5512 Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives
YP_002967465.1	negatively supercoils closed circular double-stranded DNA
YP_002967466.1	negatively supercoils closed circular double-stranded DNA
YP_002967468.1	COG4767 Glycopeptide antibiotics resistance protein
YP_002967469.1	COG1272 Predicted membrane protein, hemolysin III homolog
YP_002967470.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_002967471.1	COG0477 Permeases of the major facilitator superfamily
YP_002967474.1	COG1970 Large-conductance mechanosensitive channel
YP_002967475.1	COG2308 Uncharacterized conserved protein
YP_002967476.1	COG1451 Predicted metal-dependent hydrolase
YP_002967478.1	COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen
YP_002967480.1	COG0178 Excinuclease ATPase subunit
YP_002967481.1	COG0500 SAM-dependent methyltransferases
YP_002967483.1	COG0431 Predicted flavoprotein
YP_002967485.1	COG1198 Primosomal protein N (replication factor Y - superfamily II helicase)
YP_002967488.1	COG1694 Predicted pyrophosphatase
YP_002967492.1	COG0270 Site-specific DNA methylase
YP_002967500.1	COG3041 Uncharacterized protein conserved in bacteria
YP_002967502.1	COG2336 Growth regulator
YP_002967503.1	COG2337 Growth inhibitor
YP_002967504.1	COG0583 Transcriptional regulator
YP_002967505.1	COG0656 Aldo/keto reductases, related to diketogulonate reductase
YP_002967506.1	COG0656 Aldo/keto reductases, related to diketogulonate reductase
YP_002967507.1	COG1472 Beta-glucosidase-related glycosidases
YP_002967509.1	COG3464 Transposase and inactivated derivatives
YP_002967510.1	COG5520 O-Glycosyl hydrolase
YP_002967511.1	COG1874 Beta-galactosidase
YP_002967512.1	COG0477 Permeases of the major facilitator superfamily
YP_002967513.1	COG1309 Transcriptional regulator
YP_002967514.1	COG0783 DNA-binding ferritin-like protein (oxidative damage protectant)
YP_002967515.1	COG1253 Hemolysins and related proteins containing CBS domains
YP_002967516.1	COG0288 Carbonic anhydrase
YP_002967517.1	COG1609 Transcriptional regulators
YP_002967519.1	COG4214 ABC-type xylose transport system, permease component
YP_002967520.1	COG1129 ABC-type sugar transport system, ATPase component
YP_002967522.1	COG1609 Transcriptional regulators
YP_002967523.1	COG3534 Alpha-L-arabinofuranosidase
YP_002967524.1	COG1070 Sugar (pentulose and hexulose kinases)
YP_002967525.1	catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate
YP_002967526.1	catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism
YP_002967527.1	COG0656 Aldo/keto reductases, related to diketogulonate reductase
YP_002967528.1	COG2352 Phosphoenolpyruvate carboxylase
YP_002967529.1	COG2966 Uncharacterized conserved protein
YP_002967530.1	COG3464 Transposase and inactivated derivatives
YP_002967531.1	COG0180 Tryptophanyl-tRNA synthetase
YP_002967534.1	COG0058 Glucan phosphorylase
YP_002967536.1	COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
YP_002967537.1	COG0500 SAM-dependent methyltransferases
YP_002967538.1	integral membrane protein involved in inhibition of the Z-ring formation
YP_002967539.1	COG3879 Uncharacterized protein conserved in bacteria
YP_002967540.1	COG3764 Sortase (surface protein transpeptidase)
YP_002967541.1	COG0512 Anthranilate/para-aminobenzoate synthases component II
YP_002967542.1	COG0515 Serine/threonine protein kinase
YP_002967543.1	COG0515 Serine/threonine protein kinase
YP_002967544.1	COG0768 Cell division proteinFtsI/penicillin-binding protein 2
YP_002967545.1	COG0772 Bacterial cell division membrane protein
YP_002967546.1	COG0631 Serine/threonine protein phosphatase
YP_002967547.1	COG1716 FOG: FHA domain
YP_002967548.1	COG1716 FOG: FHA domain
YP_002967549.1	COG1506 Dipeptidylaminopeptidases/acylaminoacyl-peptidases
YP_002967550.1	COG0697 Permeases of the drug/metabolite transporter (DMT superfamily)
YP_002967551.1	COG2267 Lysophospholipase
YP_002967553.1	COG0500 SAM-dependent methyltransferases
YP_002967554.1	COG2261 Predicted membrane protein
YP_002967555.1	COG2261 Predicted membrane protein
YP_002967556.1	COG0493 NADPH-dependent glutamate synthase betachain and related oxidoreductases
YP_002967557.1	COG2217 Cation transport ATPase
YP_002967558.1	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YP_002967559.1	COG1011 Predicted hydrolase (HAD superfamily)
YP_002967560.1	COG0790 FOG: TPR repeat, SEL1 subfamily
YP_002967561.1	COG0343 Queuine/archaeosine tRNA-ribosyltransferase
YP_002967562.1	putative metalloprotease
YP_002967564.1	COG2135 Uncharacterized conserved protein
YP_002967565.1	COG2814 Arabinose efflux permease
YP_002967567.1	COG3077 DNA-damage-inducible protein J
YP_002967568.1	COG0350 Methylated DNA-protein cysteinemethyltransferase
YP_002967570.1	COG0599 Uncharacterized homolog ofgamma-carboxymuconolactone decarboxylase subunit
YP_002967571.1	COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain
YP_002967572.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002967573.1	COG0583 Transcriptional regulator
YP_002967574.1	COG0667 Predicted oxidoreductases (related toaryl-alcohol dehydrogenases)
YP_002967576.1	COG4097 Predicted ferric reductase
YP_002967577.1	COG0716 Flavodoxins
YP_002967578.1	COG0789 Predicted transcriptional regulators
YP_002967579.1	COG0716 Flavodoxins
YP_002967580.1	COG0702 Predicted nucleoside-diphosphate-sugare pimerases
YP_002967581.1	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
YP_002967582.1	COG0583 Transcriptional regulator
YP_002967583.1	COG0726 Predicted xylanase/chitin deacetylase
YP_002967584.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_002967585.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_002967586.1	COG0239 Integral membrane protein possibly involved in chromosome condensation
YP_002967587.1	COG0239 Integral membrane protein possibly involved in chromosome condensation
YP_002967588.1	COG0559 Branched-chain amino acid ABC-typetransport system, permease components
YP_002967589.1	COG4177 ABC-type branched-chain amino acid transport system, permease component
YP_002967590.1	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
YP_002967591.1	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
YP_002967592.1	COG0683 ABC-type branched-chain amino acidtransport systems, periplasmic component
YP_002967593.1	COG1609 Transcriptional regulators
YP_002967594.1	COG0366 Glycosidases
YP_002967595.1	COG0477 Permeases of the major facilitator superfamily
YP_002967596.1	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
YP_002967597.1	COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit
YP_002967599.1	COG2211 Na+/melibiose symporter and related transporters
YP_002967600.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002967601.1	COG4453 Uncharacterized protein conserved in bacteria
YP_002967603.1	COG0477 Permeases of the major facilitator superfamily
YP_002967604.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_002967607.1	COG2723Beta-glucosidase/6-phospho-beta- glucosidase/beta-galactosidase
YP_002967609.1	COG1609 Transcriptional regulators
YP_002967613.1	COG2942 N-acyl-D-glucosamine 2-epimerase
YP_002967614.1	COG4619 ABC-type uncharacterized transport system, ATPase component
YP_002967615.1	COG0390 ABC-type uncharacterized transport system, permease component
YP_002967616.1	COG1113 Gamma-aminobutyrate permease and related permeases
YP_002967617.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002967618.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002967619.1	COG1113 Gamma-aminobutyrate permease and related permeases
YP_002967620.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002967622.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002967623.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002967624.1	COG1846 Transcriptional regulators
YP_002967625.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002967626.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002967627.1	COG0726 Predicted xylanase/chitin deacetylase
YP_002967628.1	COG0671 Membrane-associated phospholipidphosphatase
YP_002967629.1	COG0110 Acetyltransferase (isoleucine patch superfamily)
YP_002967631.1	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
YP_002967632.1	COG1309 Transcriptional regulator
YP_002967633.1	COG1511 Predicted membrane protein
YP_002967634.1	COG1511 Predicted membrane protein
YP_002967635.1	COG0477 Permeases of the major facilitator superfamily
YP_002967636.1	COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
YP_002967637.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002967638.1	COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
YP_002967639.1	COG4667 Predicted esterase of the alpha-beta hydrolase superfamily
YP_002967640.1	COG1309 Transcriptional regulator
YP_002967642.1	COG4690 Dipeptidase
YP_002967643.1	COG1309 Transcriptional regulator
YP_002967644.1	COG0552 Signal recognition particle GTPase
YP_002967645.1	COG0004 Ammonia permease
YP_002967646.1	COG0347 Nitrogen regulatory protein PII
YP_002967647.1	COG2844 UTP:GlnB (protein PII uridylyl transferase)
YP_002967648.1	COG1476 Predicted transcriptional regulators
YP_002967649.1	COG0305 Replicative DNA helicase
YP_002967650.1	COG0769 UDP-N-acetylmuramyl tripeptide synthase
YP_002967651.1	COG3442 Predicted glutamine amidotransferase
YP_002967652.1	COG3937 Uncharacterized conserved protein
YP_002967653.1	COG0661 Predicted unusual protein kinase
YP_002967654.1	COG0584 Glycerophosphoryl diesterphosphodiesterase
YP_002967655.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_002967657.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_002967658.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_002967660.1	COG4962 Flp pilus assembly protein, ATPase CpaF
YP_002967661.1	COG4965 Flp pilus assembly protein TadB
YP_002967666.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_002967667.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_002967668.1	COG0527 Aspartokinases
YP_002967669.1	COG0527 Aspartokinases
YP_002967670.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_002967672.1	COG0119 Isopropylmalate/homocitrate/citramalatesynthases
YP_002967673.1	COG0744 Membrane carboxypeptidase (penicillin-binding protein)
YP_002967674.1	COG1260 Myo-inositol-1-phosphate synthase
YP_002967676.1	COG0550 Topoisomerase IA
YP_002967677.1	COG0125 Thymidylate kinase
YP_002967678.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_002967679.1	COG1881 Phospholipid-binding protein
YP_002967680.1	COG4690 Dipeptidase
YP_002967681.1	COG4690 Dipeptidase
YP_002967682.1	COG1373 Predicted ATPase (AAA+ superfamily)
YP_002967683.1	COG2759 Formyltetrahydrofolate synthetase
YP_002967684.1	COG1049 Aconitase B
YP_002967686.1	COG2246 Predicted membrane protein
YP_002967688.1	COG0406 Fructose-2,6-bisphosphatase
YP_002967689.1	COG0477 Permeases of the major facilitator superfamily
YP_002967690.1	COG3464 Transposase and inactivated derivatives
YP_002967691.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_002967692.1	COG1409 Predicted phosphohydrolases
YP_002967693.1	COG1414 Transcriptional regulator
YP_002967694.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_002967695.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_002967696.1	COG1522 Transcriptional regulators
YP_002967697.1	COG0446 Uncharacterized NAD (FAD-dependent dehydrogenases)
YP_002967698.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_002967699.1	COG0204 1-acyl-sn-glycerol-3-phosphateacyltransferase
YP_002967700.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_002967701.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_002967703.1	COG1266 Predicted metal-dependent membrane protease
YP_002967704.1	COG0668 Small-conductance mechanosensitive channel
YP_002967705.1	COG1309 Transcriptional regulator
YP_002967707.1	COG4905 Predicted membrane protein
YP_002967708.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_002967710.1	COG0457 FOG: TPR repeat
YP_002967711.1	COG0524 Sugar kinases, ribokinase family
YP_002967712.1	required for 70S ribosome assembly
YP_002967713.1	COG1200 RecG-like helicase
YP_002967716.1	COG0742 N6-adenine-specific methylase
YP_002967717.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_002967718.1	COG0806 RimM protein, required for 16S rRNA processing
YP_002967719.1	COG1837 Predicted RNA-binding protein (contains KH domain)
YP_002967720.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_002967721.1	COG3250 Beta-galactosidase/beta-glucuronidase
YP_002967722.1	COG3568 Metal-dependent hydrolase
YP_002967723.1	COG0053 Predicted Co/Zn/Cd cation transporters
YP_002967724.1	COG0541 Signal recognition particle GTPase
YP_002967725.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_002967726.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_002967727.1	COG0518 GMP synthase - Glutamine amidotransferase domain
YP_002967728.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_002967729.1	acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate
YP_002967730.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_002967731.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_002967732.1	COG1399 Predicted metal-binding, possibly nucleic acid-binding protein
YP_002967733.1	COG3599 Cell division initiation protein
YP_002967734.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_002967736.1	COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)
YP_002967737.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_002967739.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_002967740.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_002967741.1	COG2348 Uncharacterized protein involved in methicillin resistance
YP_002967742.1	COG0679 Predicted permeases
YP_002967743.1	COG0836 Mannose-1-phosphate guanylyltransferase
YP_002967744.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_002967745.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_002967746.1	COG0681 Signal peptidase I
YP_002967747.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_002967748.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002967749.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002967750.1	COG0679 Predicted permeases
YP_002967751.1	catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate
YP_002967752.1	COG1530 Ribonucleases G and E
YP_002967753.1	COG0261 Ribosomal protein L21
YP_002967754.1	involved in the peptidyltransferase reaction during translation
YP_002967755.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_002967756.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_002967757.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_002967758.1	forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_002967759.1	COG0250 Transcription antiterminator
YP_002967760.1	binds directly to 23S ribosomal RNA
YP_002967761.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_002967762.1	COG2508 Regulator of polyketide synthase expression
YP_002967763.1	COG0340 Biotin-(acetyl-CoA carboxylase ligase)
YP_002967764.1	COG1268 Uncharacterized conserved protein
YP_002967765.1	COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit
YP_002967766.1	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
YP_002967767.1	COG0331 (acyl-carrier-proteinS-malonyltransferase)
YP_002967768.1	COG0736 Phosphopantetheinyl transferase (holo-ACP synthase)
YP_002967770.1	COG0039 Malate/lactate dehydrogenases
YP_002967771.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_002967772.1	COG1185 Polyribonucleotide nucleotidyltransferase(polynucleotide phosphorylase)
YP_002967773.1	COG1704 Uncharacterized conserved protein
YP_002967774.1	COG4907 Predicted membrane protein
YP_002967775.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_002967776.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_002967777.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_002967778.1	COG0695 Glutaredoxin and related proteins
YP_002967779.1	COG0667 Predicted oxidoreductases (related toaryl-alcohol dehydrogenases)
YP_002967780.1	COG0826 Collagenase and related proteases
YP_002967781.1	COG1496 Uncharacterized conserved protein
YP_002967782.1	COG1211 4-diphosphocytidyl-2-methyl-D-erithritolsynthase
YP_002967783.1	COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)
YP_002967784.1	COG3599 Cell division initiation protein
YP_002967785.1	COG3579 Aminopeptidase C
YP_002967786.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive
YP_002967787.1	COG1835 Predicted acyltransferases
YP_002967788.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_002967789.1	COG0775 Nucleoside phosphorylase
YP_002967790.1	COG0642 Signal transduction histidine kinase
YP_002967791.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_002967792.1	COG0226 ABC-type phosphate transport system, periplasmic component
YP_002967793.1	COG0573 ABC-type phosphate transport system, permease component
YP_002967794.1	COG0581 ABC-type phosphate transport system, permease component
YP_002967795.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_002967796.1	COG2252 Permeases
YP_002967797.1	COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
YP_002967798.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_002967799.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_002967800.1	COG1716 FOG: FHA domain
YP_002967801.1	COG1112 Superfamily I DNA and RNA helicases and helicase subunits
YP_002967804.1	COG2331 Uncharacterized protein conserved in bacteria
YP_002967805.1	COG0212 5-formyltetrahydrofolate cyclo-ligase
YP_002967806.1	COG1670 Acetyltransferases, including N-acetylasesof ribosomal proteins
YP_002967808.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_002967809.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif
YP_002967810.1	COG0812 UDP-N-acetylmuramate dehydrogenase
YP_002967811.1	COG0531 Amino acid transporters
YP_002967812.1	COG1146 Ferredoxin
YP_002967813.1	catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis
YP_002967814.1	COG0389 Nucleotidyltransferase/DNA polymeraseinvolved in DNA repair
YP_002967815.1	COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
YP_002967816.1	COG1739 Uncharacterized conserved protein
YP_002967818.1	COG1640 4-alpha-glucanotransferase
YP_002967819.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_002967820.1	forms a direct contact with the tRNA during translation
YP_002967821.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
YP_002967822.1	COG1940 Transcriptional regulator/sugar kinase
YP_002967823.1	COG1012 NAD-dependent aldehyde dehydrogenases
YP_002967826.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_002967827.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_002967828.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_002967829.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_002967830.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_002967831.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_002967832.2	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_002967833.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_002967834.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_002967835.1	COG0255 Ribosomal protein L29
YP_002967836.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_002967837.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_002967838.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_002967839.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_002967840.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif
YP_002967841.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_002967842.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_002967843.1	binds 5S rRNA along with protein L5 and L25
YP_002967844.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_002967845.1	COG1841 Ribosomal protein L30/L7E
YP_002967846.1	late assembly protein
YP_002967847.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_002967848.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_002967849.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_002967850.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_002967851.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_002967852.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_002967853.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_002967854.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_002967855.1	COG0101 Pseudouridylate synthase
YP_002967857.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_002967858.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_002967859.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_002967860.1	COG0130 Pseudouridine synthase
YP_002967861.1	COG0196 FAD synthase
YP_002967862.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_002967864.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_002967865.1	COG0328 Ribonuclease HI
YP_002967866.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002967867.1	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
YP_002967868.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_002967869.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002967871.1	COG0457 FOG: TPR repeat
YP_002967872.1	COG2197 Response regulator containing a CheY-likereceiver domain and an HTH DNA-binding domain
YP_002967873.1	COG1983 Putative stress-responsive transcriptional regulator
YP_002967874.1	COG1983 Putative stress-responsive transcriptional regulator
YP_002967876.1	COG0626 Cystathionine beta-lyases/cystathioninegamma-synthases
YP_002967877.1	COG2873 O-acetylhomoserine sulfhydrylase
YP_002967878.1	COG2873 O-acetylhomoserine sulfhydrylase
YP_002967879.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_002967883.1	COG3579 Aminopeptidase C
YP_002967884.1	COG0531 Amino acid transporters
YP_002967885.1	COG2939 Carboxypeptidase C (cathepsin A)
YP_002967886.1	COG0531 Amino acid transporters
YP_002967887.1	COG1575 1,4-dihydroxy-2-naphthoateoctaprenyl transferase
YP_002967888.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_002967889.1	in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever
YP_002967890.1	COG1482 Phosphomannose isomerase
YP_002967891.1	COG0642 Signal transduction histidine kinase
YP_002967892.1	COG0704 Phosphate uptake regulator
YP_002967893.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate
YP_002967894.1	COG3942 Surface antigen
YP_002967896.1	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
YP_002967897.1	COG0589 Universal stress protein UspA and related nucleotide-binding proteins
YP_002967898.1	COG1765 Predicted redox protein, regulator of disulfide bond formation
YP_002967899.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_002967900.1	COG0262 Dihydrofolate reductase
YP_002967901.1	COG0394 Protein-tyrosine-phosphatase
YP_002967902.1	COG1087 UDP-glucose 4-epimerase
YP_002967903.1	COG0220 Predicted S-adenosylmethionine-dependent methyltransferase
YP_002967904.1	COG1434 Uncharacterized conserved protein
YP_002967906.1	COG3642 Mn2+-dependent serine/threonine protein kinase
YP_002967907.1	COG3593 Predicted ATP-dependent endonuclease of the OLD family
YP_002967910.1	COG4487 Uncharacterized protein conserved in bacteria
YP_002967913.1	COG4913 Uncharacterized protein conserved in bacteria
YP_002967914.1	COG4924 Uncharacterized protein conserved in bacteria
YP_002967915.1	COG3189 Uncharacterized conserved protein
YP_002967916.1	COG2211 Na+/melibiose symporter and related transporters
YP_002967917.1	COG3250 Beta-galactosidase/beta-glucuronidase
YP_002967918.1	COG1609 Transcriptional regulators
YP_002967919.1	COG1011 Predicted hydrolase (HAD superfamily)
YP_002967924.1	COG1653 ABC-type sugar transport system, periplasmic component
YP_002967925.1	COG1874 Beta-galactosidase
YP_002967926.1	COG0395 ABC-type sugar transport system, permease component
YP_002967927.1	COG1175 ABC-type sugar transport systems, permease components
YP_002967928.1	COG1609 Transcriptional regulators
YP_002967929.1	COG0463 Glycosyl transferases involved in cell wall biogenesis
YP_002967930.1	COG0628 Predicted permease
YP_002967931.1	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
YP_002967932.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002967934.1	COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)
YP_002967935.1	COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
YP_002967936.1	COG0634 Hypoxanthine-guaninephosphoribosyltransferase
YP_002967937.1	COG0465 ATP-dependent Zn proteases
YP_002967940.1	COG1946 Acyl-CoA thioesterase
YP_002967941.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_002967942.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_002967943.1	COG2873 O-acetylhomoserine sulfhydrylase
YP_002967944.1	COG4721 Predicted membrane protein
YP_002967947.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_002967948.1	catalyzes the interconversion of D-xylose to D-xylulose
YP_002967949.1	COG3507 Beta-xylosidase
YP_002967950.1	COG1609 Transcriptional regulators
YP_002967951.1	COG1653 ABC-type sugar transport system, periplasmic component
YP_002967952.1	COG1175 ABC-type sugar transport systems, permease components
YP_002967953.1	COG0395 ABC-type sugar transport system, permease component
YP_002967954.1	COG3507 Beta-xylosidase
YP_002967956.1	COG2272 Carboxylesterase type B
YP_002967957.1	COG3507 Beta-xylosidase
YP_002967958.1	COG1070 Sugar (pentulose and hexulose kinases)
YP_002967959.1	COG1940 Transcriptional regulator/sugar kinase
YP_002967960.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_002967961.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_002967962.1	COG2890 Methylase of polypeptide chain release factors
YP_002967963.1	COG0009 Putative translation factor (SUA5)
YP_002967964.1	COG0472 UDP-N-acetylmuramyl pentapeptidephosphotransferase/UDP-N-acetylglucosamine-1- phosphatetransferase
YP_002967965.1	COG0516 IMP dehydrogenase/GMP reductase
YP_002967966.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_002967967.1	COG0561 Predicted hydrolases of the HAD superfamily
YP_002967968.1	COG0507 ATP-dependent exoDNAse (exonuclease V, alpha subunit - helicase superfamily I member)
YP_002967970.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_002967971.1	COG0629 Single-stranded DNA-binding protein
YP_002967972.1	COG3590 Predicted metalloendopeptidase
YP_002967973.1	COG3247 Uncharacterized conserved protein
YP_002967974.1	COG0024 Methionine aminopeptidase
YP_002967975.1	COG0372 Citrate synthase
YP_002967976.1	SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_002967977.1	COG2171 TetrahydrodipicolinateN-succinyltransferase
YP_002967979.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_002967980.1	COG2884 Predicted ATPase involved in cell division
YP_002967981.1	COG2177 Cell division protein
YP_002967982.1	COG3942 Surface antigen
YP_002967983.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_002967985.1	COG0834 ABC-type amino acid transport/signaltransduction systems, periplasmic component/domain
YP_002967986.1	COG0834 ABC-type amino acid transport/signaltransduction systems, periplasmic component/domain
YP_002967987.1	COG0765 ABC-type amino acid transport system, permease component
YP_002967988.1	COG1126 ABC-type polar amino acid transport system, ATPase component
YP_002967990.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
YP_002967991.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_002967992.1	COG0564 Pseudouridylate synthases, 23SRNA-specific
YP_002967994.1	type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP
YP_002967995.1	COG0747 ABC-type dipeptide transport system, periplasmic component
YP_002967996.1	COG0601 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002967997.1	COG1173 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002967998.1	COG4172 ABC-type uncharacterized transport system, duplicated ATPase component
YP_002967999.1	COG1123 ATPase components of various ABC-typetransport systems, contain duplicated ATPase
YP_002968000.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_002968001.1	COG0031 Cysteine synthase
YP_002968002.1	COG0514 Superfamily II DNA helicase
YP_002968003.1	COG2852 Uncharacterized protein conserved in bacteria
YP_002968004.1	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
YP_002968010.1	COG0494 NTP pyrophosphohydrolases includingoxidative damage repair enzymes
YP_002968011.1	COG3886 Predicted HKD family nuclease
YP_002968012.1	COG3177 Uncharacterized conserved protein
YP_002968013.1	COG1479 Uncharacterized conserved protein
YP_002968014.1	COG3600 Uncharacterized phage-associated protein
YP_002968015.1	COG3654 Prophage maintenance system killer protein
YP_002968016.1	COG1247 Sortase and related acyltransferases
YP_002968017.1	COG3752 Predicted membrane protein
YP_002968018.1	COG0371 Glycerol dehydrogenase and related enzymes
YP_002968019.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_002968020.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002968021.1	COG0787 Alanine racemase
YP_002968022.1	synthesizes RNA primers at the replication forks
YP_002968023.1	COG0471 Di- and tricarboxylate transporters
YP_002968024.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_002968025.1	COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR mutase)
YP_002968026.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_002968027.1	COG0735 Fe2+/Zn2+ uptake regulation proteins
YP_002968028.1	COG2898 Uncharacterized conserved protein
YP_002968029.1	COG0627 Predicted esterase
YP_002968030.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_002968031.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_002968032.1	COG0034 Glutamine phosphoribosylpyrophosphateamidotransferase
YP_002968033.1	COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair
YP_002968035.1	COG3597 Uncharacterized protein/domain associated with GTPases
YP_002968037.1	COG3467 Predicted flavin-nucleotide-binding protein
YP_002968038.1	COG1396 Predicted transcriptional regulators
YP_002968045.1	COG4260 Putative virion core protein (lumpy skin disease virus)
YP_002968046.1	COG0046 Phosphoribosylformylglycinamidine (FGAM synthase, synthetase domain)
YP_002968047.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_002968048.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_002968049.1	COG0438 Glycosyltransferase
YP_002968050.1	COG2008 Threonine aldolase
YP_002968052.2	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_002968053.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_002968054.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_002968055.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_002968057.1	COG0492 Thioredoxin reductase
YP_002968058.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_002968059.1	COG0781 Transcription termination factor
YP_002968060.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_002968061.1	COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
YP_002968062.1	COG0284 Orotidine-5-phosphate decarboxylase
YP_002968063.1	Essential for recycling GMP and indirectly, cGMP
YP_002968064.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_002968065.1	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_002968066.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_002968067.1	COG2230 Cyclopropane fatty acid synthase and related methyltransferases
YP_002968068.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_002968069.1	COG0223 Methionyl-tRNA formyltransferase
YP_002968070.1	COG0560 Phosphoserine phosphatase
YP_002968071.1	COG0586 Uncharacterized membrane-associated protein
YP_002968072.1	COG0464 ATPases of the AAA+ class
YP_002968074.1	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
YP_002968077.1	COG0776 Bacterial nucleoid DNA-binding protein
YP_002968078.1	COG0392 Predicted integral membrane protein
YP_002968079.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_002968080.1	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
YP_002968084.1	COG2304 Uncharacterized protein containing a vonWillebrand factor type A (vWA domain)
YP_002968086.1	COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWAdomain))
YP_002968087.1	COG0714 MoxR-like ATPases
YP_002968088.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_002968090.1	COG1278 Cold shock proteins
YP_002968091.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_002968094.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_002968095.1	COG0642 Signal transduction histidine kinase
YP_002968096.1	COG1278 Cold shock proteins
YP_002968099.1	COG0589 Universal stress protein UspA and related nucleotide-binding proteins
YP_002968100.1	COG0542 ATPases with chaperone activity, ATP-binding subunit
YP_002968101.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_002968102.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_002968104.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002968105.1	COG1126 ABC-type polar amino acid transport system, ATPase component
YP_002968106.1	COG0834 ABC-type amino acid transport/signaltransduction systems, periplasmic component/domain
YP_002968107.1	COG0765 ABC-type amino acid transport system, permease component
YP_002968108.1	COG0765 ABC-type amino acid transport system, permease component
YP_002968109.1	COG2326 Uncharacterized conserved protein
YP_002968110.1	COG4581 Superfamily II RNA helicase
YP_002968111.1	COG2256 ATPase related to the helicase subunit ofthe Holliday junction resolvase
YP_002968112.1	COG0477 Permeases of the major facilitator superfamily
YP_002968113.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
YP_002968114.1	COG3328 Transposase and inactivated derivatives
YP_002968116.1	COG4715 Uncharacterized conserved protein
YP_002968117.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002968118.1	COG3824 Uncharacterized protein conserved in bacteria
YP_002968119.1	COG3304 Predicted membrane protein
YP_002968120.1	COG0819 Putative transcription activator
YP_002968121.1	COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
YP_002968122.1	COG0656 Aldo/keto reductases, related to diketogulonate reductase
YP_002968123.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002968124.1	COG3601 Predicted membrane protein
YP_002968125.1	COG1940 Transcriptional regulator/sugar kinase
YP_002968126.1	COG0436 Aspartate/tyrosine/aromatic aminotransferase
YP_002968127.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002968130.1	COG0272 NAD-dependent DNA ligase (contains BRCT domain type II)
YP_002968131.1	COG0489 ATPases involved in chromosome partitioning
YP_002968132.1	COG4721 Predicted membrane protein
YP_002968133.1	COG0174 Glutamine synthetase
YP_002968134.1	COG0532 Translation initiation factor 2 (IF-2; GTPase)
YP_002968135.1	COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3 component, and related enzymes)
YP_002968137.1	COG0624 Acetylornithinedeacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases
YP_002968138.1	COG4585 Signal transduction histidine kinase
YP_002968141.1	COG3409 Putative peptidoglycan-binding domain-containing protein
YP_002968143.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002968145.1	COG4721 Predicted membrane protein
YP_002968146.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002968147.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002968148.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002968150.1	COG0566 rRNA methylases
YP_002968151.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_002968152.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_002968154.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_002968155.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_002968156.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_002968157.1	catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine
YP_002968158.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
YP_002968159.1	COG1438 Arginine repressor
YP_002968160.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_002968161.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_002968162.1	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
YP_002968163.1	COG1418 Predicted HD superfamily hydrolase
YP_002968164.1	COG0162 Tyrosyl-tRNA synthetase
YP_002968166.1	COG0647 Predicted sugar phosphatases of the HAD superfamily
YP_002968167.1	COG1189 Predicted rRNA methylase
YP_002968168.1	COG0168 Trk-type K+ transport systems, membrane components
YP_002968169.1	COG0569 K+ transport systems, NAD-binding component
YP_002968170.1	catalyzes the phosphorylation of NAD to NADP
YP_002968171.1	COG0497 ATPase involved in DNA repair
YP_002968172.1	COG0637 Predicted phosphatase/phosphohexomutase
YP_002968173.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_002968174.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_002968176.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_002968177.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_002968178.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_002968179.1	COG0799 Uncharacterized homolog of plant Iojap protein
YP_002968180.1	COG0406 Fructose-2,6-bisphosphatase
YP_002968182.1	COG3576 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5-phosphate oxidase
YP_002968183.1	COG0406 Fructose-2,6-bisphosphatase
YP_002968184.1	COG0598 Mg2+ and Co2+ transporters
YP_002968185.1	COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
YP_002968186.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_002968187.1	COG1555 DNA uptake protein and related DNA-binding proteins
YP_002968188.1	COG0658 Predicted membrane metal-binding protein
YP_002968189.1	COG1466 DNA polymerase III, delta subunit
YP_002968190.1	COG0802 Predicted ATPase or kinase
YP_002968191.1	COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone
YP_002968192.1	COG0456 Acetyltransferases
YP_002968193.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_002968196.1	COG0739 Membrane proteins related to metalloendopeptidases
YP_002968197.1	COG4213 ABC-type xylose transport system, periplasmic component
YP_002968198.1	Converts isocitrate to alpha ketoglutarate
YP_002968199.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_002968201.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
YP_002968202.1	COG0242 N-formylmethionyl-tRNA deformylase
YP_002968203.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_002968204.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_002968205.1	Catalyzes the phosphorylation of UMP to UDP
YP_002968206.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_002968207.1	COG0575 CDP-diglyceride synthetase
YP_002968208.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_002968209.1	COG1309 Transcriptional regulator
YP_002968210.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002968211.1	COG0842 ABC-type multidrug transport system, permease component
YP_002968212.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_002968213.1	PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers
YP_002968214.1	COG0147 Anthranilate/para-aminobenzoate synthases component I
YP_002968215.1	COG1573 Uracil-DNA glycosylase
YP_002968218.1	catalyzes ring closure to form indole-3-glycerol phosphate; catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_002968219.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_002968220.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_002968221.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_002968222.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis
YP_002968223.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_002968224.1	COG0558 Phosphatidylglycerophosphate synthase
YP_002968225.1	COG3879 Uncharacterized protein conserved in bacteria
YP_002968226.1	COG3856 Uncharacterized conserved protein (small basic protein)
YP_002968227.1	COG3879 Uncharacterized protein conserved in bacteria
YP_002968228.1	COG1716 FOG: FHA domain
YP_002968229.1	COG0789 Predicted transcriptional regulators
YP_002968231.1	COG0239 Integral membrane protein possibly involved in chromosome condensation
YP_002968232.1	COG0239 Integral membrane protein possibly involved in chromosome condensation
YP_002968233.1	COG0546 Predicted phosphatases
YP_002968235.1	COG4581 Superfamily II RNA helicase
YP_002968237.1	COG2378 Predicted transcriptional regulator
YP_002968238.1	COG4284 UDP-glucose pyrophosphorylase
YP_002968239.1	CMK catalyzes the formation of (d)CDP from ATP and (d)CMP; the function of the GTP-binding domain EngA appears to be in synchronizing cellular events by interacting with multiple cellular targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide-binding affinities in the two binding domains
YP_002968240.1	COG1187 16S rRNA uridine-516 pseudo uridylatesynthase and related pseudouridylate synthases
YP_002968241.1	COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
YP_002968243.1	involved in de novo purine biosynthesis
YP_002968245.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_002968246.1	COG0045 Succinyl-CoA synthetase, beta subunit
YP_002968247.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_002968248.1	COG1862 Preprotein translocase subunit YajC
YP_002968249.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_002968250.1	COG0632 Holliday junction resolvasome, DNA-binding subunit
YP_002968251.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_002968252.1	COG0217 Uncharacterized conserved protein
YP_002968253.1	COG0438 Glycosyltransferase
YP_002968254.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_002968255.1	COG0558 Phosphatidylglycerophosphate synthase
YP_002968256.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_002968257.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_002968258.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002968262.1	phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_002968263.1	COG3001 Fructosamine-3-kinase
YP_002968264.1	COG0484 DnaJ-class molecular chaperone withC-terminal Zn finger domain
YP_002968265.1	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
YP_002968266.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_002968267.1	catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate
YP_002968268.1	COG1357 Uncharacterized low-complexity proteins
YP_002968269.1	COG0436 Aspartate/tyrosine/aromatic aminotransferase
YP_002968270.1	COG1522 Transcriptional regulators
YP_002968271.1	in Corynebacterium glutamicum the aminotransferase can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; this protein contains a helix-turn-helix domain at the N-terminus
YP_002968272.1	COG0561 Predicted hydrolases of the HAD superfamily
YP_002968274.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_002968275.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_002968276.1	COG1481 Uncharacterized protein conserved in bacteria
YP_002968277.1	COG1660 Predicted P-loop-containing kinase
YP_002968278.1	COG0169 Shikimate 5-dehydrogenase
YP_002968279.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_002968280.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_002968282.1	COG3663 G:T/U mismatch-specific DNA glycosylase
YP_002968283.1	COG0400 Predicted esterase
YP_002968284.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_002968285.1	COG0053 Predicted Co/Zn/Cd cation transporters
YP_002968286.1	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
YP_002968287.1	COG3049 Penicillin V acylase and related amidases
YP_002968288.1	COG0062 Uncharacterized conserved protein
YP_002968289.1	COG0450 Peroxiredoxin
YP_002968290.1	COG0492 Thioredoxin reductase
YP_002968291.1	COG0583 Transcriptional regulator
YP_002968292.1	COG1011 Predicted hydrolase (HAD superfamily)
YP_002968293.1	COG2852 Uncharacterized protein conserved in bacteria
YP_002968294.1	COG1397 ADP-ribosylglycohydrolase
YP_002968295.1	COG1733 Predicted transcriptional regulators
YP_002968297.1	COG0456 Acetyltransferases
YP_002968298.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_002968299.1	COG0167 Dihydroorotate dehydrogenase
YP_002968300.1	COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
YP_002968301.1	COG0284 Orotidine-5-phosphate decarboxylase
YP_002968302.1	COG0044 Dihydroorotase and related cyclicamidohydrolases
YP_002968303.1	involved in the allosteric regulation of aspartate carbamoyltransferase
YP_002968304.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_002968306.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_002968307.1	COG0685 5,10-methylenetetrahydrofolate reductase
YP_002968308.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_002968309.1	COG2062 Phosphohistidine phosphatase SixA
YP_002968310.1	COG2519 tRNA (1-methyladenosine methyltransferase and related methyltransferases)
YP_002968311.1	COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA
YP_002968312.1	COG0438 Glycosyltransferase
YP_002968313.1	COG1225 Peroxiredoxin
YP_002968315.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_002968316.1	COG0067 Glutamate synthase domain 1
YP_002968317.1	COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases
YP_002968318.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_002968319.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_002968320.1	COG2860 Predicted membrane protein
YP_002968321.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_002968322.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_002968323.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002968324.1	COG1282 NAD/NADP transhydrogenase beta subunit
YP_002968325.1	COG3288 NAD/NADP transhydrogenase alpha subunit
YP_002968326.1	COG3288 NAD/NADP transhydrogenase alpha subunit
YP_002968327.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
YP_002968328.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_002968329.1	COG1253 Hemolysins and related proteins containing CBS domains
YP_002968330.1	COG0319 Predicted metal-dependent hydrolase
YP_002968331.1	COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase
YP_002968332.1	COG0537 Diadenosine tetraphosphate (Ap4A hydrolase and other HIT family hydrolases)
YP_002968333.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_002968334.1	COG0566 rRNA methylases
YP_002968336.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_002968337.1	COG2151 Predicted metal-sulfur cluster biosynthetic enzyme
YP_002968338.1	COG0822 NifU homolog involved in Fe-S cluster formation
YP_002968339.1	COG0520 Selenocysteine lyase
YP_002968340.1	COG0396 ABC-type transport system involved in Fe-Scluster assembly, ATPase component
YP_002968341.1	COG0719 ABC-type transport system involved in Fe-Scluster assembly, permease component
YP_002968342.1	COG0719 ABC-type transport system involved in Fe-Scluster assembly, permease component
YP_002968343.1	COG1376 Uncharacterized protein conserved in bacteria
YP_002968345.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_002968347.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
YP_002968356.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_002968357.1	catalyzes the formation of shikimate 3-phosphate from shikimate and the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_002968358.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_002968360.1	COG1559 Predicted periplasmic solute-binding protein
YP_002968361.1	COG0816 Predicted endonuclease involved inrecombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis)
YP_002968362.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002968365.1	COG0406 Fructose-2,6-bisphosphatase
YP_002968366.1	COG1950 Predicted membrane protein
YP_002968367.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_002968368.1	COG0210 Superfamily I DNA and RNA helicases
YP_002968369.1	Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine
YP_002968370.1	COG2233 Xanthine/uracil permeases
YP_002968372.1	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
YP_002968373.1	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
YP_002968375.1	COG0366 Glycosidases
YP_002968376.1	COG2071 Predicted glutamine amidotransferases
YP_002968377.1	COG3760 Uncharacterized conserved protein
YP_002968379.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002968380.1	COG1725 Predicted transcriptional regulators
YP_002968381.1	COG1396 Predicted transcriptional regulators
YP_002968382.1	COG1816 Adenosine deaminase
YP_002968384.1	COG1605 Chorismate mutase
YP_002968386.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002968387.1	COG0563 Adenylate kinase and related kinases
YP_002968388.1	COG1373 Predicted ATPase (AAA+ superfamily)
YP_002968390.1	COG0480 Translation elongation factors (GTPases)
YP_002968391.1	COG3039 Transposase and inactivated derivatives, IS5 family
YP_002968392.1	COG0107 Imidazoleglycerol-phosphate synthase
YP_002968393.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_002968394.1	COG3957 Phosphoketolase
YP_002968395.1	COG0857 BioD-like N-terminal domain of phosphotransacetylase
YP_002968396.1	COG0282 Acetate kinase
YP_002968397.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_002968399.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
YP_002968400.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_002968401.1	COG0327 Uncharacterized conserved protein
YP_002968402.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_002968403.1	COG3707 Response regulator with putative antiterminator output domain
YP_002968404.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_002968405.1	COG0469 Pyruvate kinase
YP_002968406.1	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
YP_002968407.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_002968408.1	COG0237 Dephospho-CoA kinase
YP_002968409.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_002968410.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_002968411.1	COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
YP_002968412.1	COG1121 ABC-type Mn/Zn transport systems, ATPase component
YP_002968413.1	COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
YP_002968414.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_002968415.1	COG1329 Transcriptional regulators, similar to M.xanthus CarD
YP_002968416.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_002968417.1	COG0745 Response regulators consisting of aCheY-like receiver domain and a winged-helix DNA-binding domain
YP_002968418.1	COG0642 Signal transduction histidine kinase
YP_002968419.1	COG1040 Predicted amidophosphoribosyltransferases
YP_002968420.1	COG0561 Predicted hydrolases of the HAD superfamily
YP_002968423.1	COG1216 Predicted glycosyltransferases
YP_002968424.1	COG1316 Transcriptional regulator
YP_002968425.1	COG1316 Transcriptional regulator
YP_002968426.1	COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
YP_002968428.1	COG3920 Signal transduction histidine kinase
YP_002968429.1	COG0330 Membrane protease subunits, stomatin/prohibitin homologs
YP_002968430.1	COG0782 Transcription elongation factor
YP_002968431.1	COG0545 FKBP-type peptidyl-prolyl cis-transisomerases 1
YP_002968432.1	COG1760 L-serine deaminase
YP_002968434.1	COG0248 Exopolyphosphatase
YP_002968435.1	COG1507 Uncharacterized conserved protein
YP_002968436.1	COG2919 Septum formation initiator
YP_002968437.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_002968438.1	COG0600 ABC-type nitrate/sulfonate/bicarbonatetransport system, permease component
YP_002968439.1	COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
YP_002968440.1	COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component
YP_002968441.1	COG1197 Transcription-repair coupling factor (superfamily II helicase)
YP_002968442.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_002968443.1	COG1247 Sortase and related acyltransferases
YP_002968444.1	COG1615 Uncharacterized conserved protein
YP_002968445.1	COG1472 Beta-glucosidase-related glycosidases
YP_002968446.1	COG2879 Uncharacterized small protein
YP_002968447.1	COG1966 Carbon starvation protein, predicted membrane protein
YP_002968448.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002968449.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002968450.1	COG3910 Predicted ATPase
YP_002968452.1	COG1846 Transcriptional regulators
YP_002968454.1	catalyzes the formation of fumarate from aspartate
YP_002968455.1	COG1918 Fe2+ transport system protein A
YP_002968456.1	COG0370 Fe2+ transport system protein B
YP_002968458.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_002968459.1	COG3429 Glucose-6-P dehydrogenase subunit
YP_002968460.1	COG03636-phosphogluconolactonase/Glucosamine-6- phosphateisomerase/deaminase
YP_002968461.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_002968462.1	COG3340 Peptidase E
YP_002968463.1	COG1114 Branched-chain amino acid permeases
YP_002968464.1	COG0225 Peptide methionine sulfoxide reductase
YP_002968465.1	COG4633 Uncharacterized protein conserved in bacteria
YP_002968466.1	COG0300 Short-chain dehydrogenases of various substrate specificities
YP_002968467.1	COG0513 Superfamily II DNA and RNA helicases
YP_002968468.1	COG2855 Predicted membrane protein
YP_002968469.1	COG2233 Xanthine/uracil permeases
YP_002968470.1	COG0657 Esterase/lipase
YP_002968472.1	COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain
YP_002968473.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_002968474.1	COG0345 Pyrroline-5-carboxylate reductase
YP_002968475.1	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
YP_002968476.1	COG4585 Signal transduction histidine kinase
YP_002968477.1	COG2197 Response regulator containing a CheY-likereceiver domain and an HTH DNA-binding domain
YP_002968478.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002968479.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002968480.1	COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
YP_002968481.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002968483.1	COG2873 O-acetylhomoserine sulfhydrylase
YP_002968484.1	COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase
YP_002968485.1	COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase
YP_002968486.1	COG0606 Predicted ATPase with chaperone activity
YP_002968487.1	COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake
YP_002968488.1	COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
YP_002968489.1	COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit
YP_002968490.1	COG4122 Predicted O-methyltransferase
YP_002968491.1	COG1611 Predicted Rossmann fold nucleotide-binding protein
YP_002968492.1	COG3004 Na+/H+ antiporter
YP_002968493.1	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
YP_002968494.1	binds and unfolds substrates as part of the ClpXP protease
YP_002968495.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_002968496.1	COG0740 Protease subunit of ATP-dependent Clp proteases
YP_002968497.1	COG0038 Chloride channel protein EriC
YP_002968498.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_002968499.1	COG0349 Ribonuclease D
YP_002968500.1	COG1180 Pyruvate-formate lyase-activating enzyme
YP_002968501.1	COG1882 Pyruvate-formate lyase
YP_002968503.1	COG0388 Predicted amidohydrolase
YP_002968504.1	COG1473 Metal-dependentamidase/aminoacylase/carboxypeptidase
YP_002968505.1	COG2011 ABC-type metal ion transport system, permease component
YP_002968506.1	COG1135 ABC-type metal ion transport system, ATPase component
YP_002968507.1	COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen
YP_002968508.1	COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase - cyclophilin family)
YP_002968509.1	COG0317 Guanosine polyphosphatepyrophosphohydrolases/synthetases
YP_002968510.1	COG0756 dUTPase
YP_002968513.1	COG1524 Uncharacterized proteins of the AP superfamily
YP_002968514.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_002968515.1	COG4975 Putative glucose uptake permease
YP_002968516.1	COG1201 Lhr-like helicases
YP_002968518.1	COG0738 Fucose permease
YP_002968519.1	COG0438 Glycosyltransferase
YP_002968520.1	COG0187 Type IIA topoisomerase (DNA gyrase/topo II,topoisomerase IV, B subunit)
YP_002968521.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YP_002968523.1	COG0142 Geranylgeranyl pyrophosphate synthase
YP_002968524.1	COG0515 Serine/threonine protein kinase
YP_002968525.1	COG0204 1-acyl-sn-glycerol-3-phosphateacyltransferase
YP_002968527.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_002968528.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_002968529.1	COG1544 Ribosome-associated protein Y (PSrp-1)
YP_002968531.1	COG2137 Uncharacterized protein conserved in bacteria
YP_002968532.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_002968534.1	COG1396 Predicted transcriptional regulators
YP_002968535.1	COG1546 Uncharacterized protein (competence- andmitomycin-induced)
YP_002968536.1	COG0558 Phosphatidylglycerophosphate synthase
YP_002968537.1	COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
YP_002968538.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_002968539.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_002968540.1	COG2357 Uncharacterized protein conserved in bacteria
YP_002968541.1	COG0670 Integral membrane protein, interacts withFtsH
YP_002968542.1	COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase
YP_002968544.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002968545.1	COG4585 Signal transduction histidine kinase
YP_002968546.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
YP_002968548.1	COG3464 Transposase and inactivated derivatives
YP_002968549.1	COG1479 Uncharacterized conserved protein
YP_002968550.1	COG0110 Acetyltransferase (isoleucine patch superfamily)
YP_002968552.1	Catalyzes the conversion of citrate to isocitrate
YP_002968553.1	COG0474 Cation transport ATPase
YP_002968555.1	COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5--methyltransferase)
YP_002968558.1	COG0708 Exonuclease III
YP_002968560.1	COG1123 ATPase components of various ABC-typetransport systems, contain duplicated ATPase
YP_002968561.1	COG1173 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002968562.1	COG0601 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002968563.1	COG0747 ABC-type dipeptide transport system, periplasmic component
YP_002968564.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_002968565.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002968566.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002968568.1	COG0287 Prephenate dehydrogenase
YP_002968569.1	COG0077 Prephenate dehydratase
YP_002968571.1	COG1217 Predicted membrane GTPase involved instress response
YP_002968572.1	COG0477 Permeases of the major facilitator superfamily
YP_002968573.1	COG1051 ADP-ribose pyrophosphatase
YP_002968574.1	COG1192 ATPases involved in chromosome partitioning
YP_002968575.1	COG4974 Site-specific recombinase XerD
YP_002968576.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_002968578.1	COG0290 Translation initiation factor 3 (IF-3)
YP_002968579.1	COG1564 Thiamine pyrophosphokinase
YP_002968580.1	COG0057 Glyceraldehyde-3-phosphatedehydrogenase/erythrose-4- phosphate dehydrogenase
YP_002968581.1	COG2606 Uncharacterized conserved protein
YP_002968582.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_002968583.1	COG2017 Galactose mutarotase and related enzymes
YP_002968585.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_002968586.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_002968587.1	COG2348 Uncharacterized protein involved in methicillin resistance
YP_002968588.1	COG0285 Folylpolyglutamate synthase
YP_002968589.1	COG2197 Response regulator containing a CheY-likereceiver domain and an HTH DNA-binding domain
YP_002968590.1	COG4585 Signal transduction histidine kinase
YP_002968592.1	COG0006 Xaa-Pro aminopeptidase
YP_002968593.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_002968594.1	COG1940 Transcriptional regulator/sugar kinase
YP_002968595.1	COG0524 Sugar kinases, ribokinase family
YP_002968596.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_002968597.1	COG0582 Integrase
YP_002968599.1	COG3311 Predicted transcriptional regulator
YP_002968604.1	COG0305 Replicative DNA helicase
YP_002968609.1	COG3740 Phage head maturation protease
YP_002968611.1	COG1123 ATPase components of various ABC-typetransport systems, contain duplicated ATPase
YP_002968612.1	COG1173 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002968613.1	COG0601 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002968614.1	COG1589 Cell division septal protein
YP_002968615.1	COG0773 UDP-N-acetylmuramate-alanine ligase
YP_002968616.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_002968617.1	COG0772 Bacterial cell division membrane protein
YP_002968618.1	COG0771 UDP-N-acetylmuramoylalanine-D-glutamateligase
YP_002968619.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_002968620.1	COG0770 UDP-N-acetylmuramyl pentapeptide synthase
YP_002968621.1	COG0769 UDP-N-acetylmuramyl tripeptide synthase
YP_002968622.1	COG0768 Cell division proteinFtsI/ penicillin-binding protein 2
YP_002968624.1	COG0275 Predicted S-adenosylmethionine-dependentmethyltransferase involved in cell envelope biogenesis
YP_002968625.1	COG2001 Uncharacterized protein conserved in bacteria
YP_002968626.1	COG3973 Superfamily I DNA and RNA helicases
YP_002968627.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_002968628.1	COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains
YP_002968629.1	COG1388 FOG: LysM repeat
YP_002968630.1	Represses a number of genes involved in the response to DNA damage
YP_002968631.1	COG1230 Co/Zn/Cd efflux system component
YP_002968632.1	COG0039 Malate/lactate dehydrogenases
YP_002968633.1	COG2262 GTPases
YP_002968634.1	COG2813 16S RNA G1207 methylase RsmC
YP_002968635.1	COG1643 HrpA-like helicases
YP_002968636.1	COG0174 Glutamine synthetase
YP_002968637.1	COG4320 Uncharacterized protein conserved in bacteria
YP_002968638.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis
YP_002968639.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_002968641.1	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_002968642.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_002968643.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_002968644.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_002968646.1	COG0564 Pseudouridylate synthases, 23SRNA-specific
YP_002968647.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_002968648.1	COG3599 Cell division initiation protein
YP_002968649.1	COG0762 Predicted integral membrane protein
YP_002968650.1	COG1799 Uncharacterized protein conserved in bacteria
YP_002968651.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_002968652.1	COG0042 tRNA-dihydrouridine synthase
YP_002968653.1	Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002968654.1	COG2145 Hydroxyethylthiazole kinase, sugar kinase family
YP_002968655.1	COG0352 Thiamine monophosphate synthase
YP_002968656.1	COG0011 Uncharacterized conserved protein
YP_002968657.1	COG1609 Transcriptional regulators
YP_002968658.1	lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments
YP_002968659.1	COG1621 Beta-fructosidases (levanase/invertase)
YP_002968660.1	COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
YP_002968661.1	COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
YP_002968662.1	COG1957 Inosine-uridine nucleoside N-ribohydrolase
YP_002968664.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_002968665.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_002968666.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002968667.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_002968668.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_002968670.1	COG1196 Chromosome segregation ATPases
YP_002968671.1	COG2303 Choline dehydrogenase and related flavoproteins
YP_002968672.1	COG3480 Predicted secreted protein containing a PDZ domain
YP_002968673.1	COG5282 Uncharacterized conserved protein
YP_002968674.1	COG0210 Superfamily I DNA and RNA helicases
YP_002968675.1	COG3173 Predicted aminoglycosidephosphotransferase
YP_002968677.1	COG0613 Predicted metal-dependent phosphoesterases (PHP family)
YP_002968678.1	COG4243 Predicted membrane protein
YP_002968679.1	COG0253 Diaminopimelate epimerase
YP_002968680.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_002968681.1	COG4667 Predicted esterase of the alpha-betahydrolase superfamily
YP_002968682.1	COG0330 Membrane protease subunits, stomatin/prohibitin homologs
YP_002968683.1	COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
YP_002968684.1	COG1126 ABC-type polar amino acid transport system, ATPase component
YP_002968685.1	COG0765 ABC-type amino acid transport system, permease component
YP_002968686.1	COG0765 ABC-type amino acid transport system, permease component
YP_002968687.1	COG0436 Aspartate/tyrosine/aromatic aminotransferase
YP_002968688.1	COG2011 ABC-type metal ion transport system, permease component
YP_002968689.1	COG1135 ABC-type metal ion transport system, ATPase component
YP_002968690.1	COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen
YP_002968691.1	COG1893 Ketopantoate reductase
YP_002968692.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002968693.1	COG2176 DNA polymerase III, alpha subunit (gram-positive type)
YP_002968694.1	COG0480 Translation elongation factors (GTPases)
YP_002968695.1	COG0531 Amino acid transporters
YP_002968698.1	COG4166 ABC-type oligopeptide transport system, periplasmic component
YP_002968699.1	COG0477 Permeases of the major facilitator superfamily
YP_002968700.1	COG1842 Phage shock protein A (IM30, suppresses sigma54-dependent transcription)
YP_002968703.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin)
YP_002968705.1	COG2365 Protein tyrosine/serine phosphatase
YP_002968708.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002968709.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002968710.1	COG1846 Transcriptional regulators
YP_002968711.1	COG0431 Predicted flavoprotein
YP_002968712.1	COG3727 DNA G:T-mismatch repair endonuclease
YP_002968716.1	COG1196 Chromosome segregation ATPases
YP_002968719.1	COG1343 Uncharacterized protein predicted to beinvolved in DNA repair
YP_002968720.1	COG1518; COG1468 RecB family exonuclease/transl_table
YP_002968721.1	COG3572 Gamma-glutamylcysteine synthetase
YP_002968722.1	COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)
YP_002968723.1	COG3548 Predicted integral membrane protein
YP_002968724.1	COG3759 Predicted membrane protein
YP_002968726.1	COG0602 Organic radical activating enzymes
YP_002968727.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_002968728.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_002968729.1	COG1722 Exonuclease VII small subunit
YP_002968730.1	COG3021 Uncharacterized protein conserved in bacteria
YP_002968732.1	COG0436 Aspartate/tyrosine/aromatic aminotransferase
YP_002968733.1	COG3727 DNA G:T-mismatch repair endonuclease
YP_002968735.1	COG0847 DNA polymerase III, epsilon subunit and related 3-5 exonucleases
YP_002968736.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_002968737.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_002968738.1	COG0308 Aminopeptidase N
YP_002968739.1	COG0595 Predicted hydrolase of themetallo-beta-lactamase superfamily
YP_002968740.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_002968741.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_002968742.1	COG0477 Permeases of the major facilitator superfamily
YP_002968743.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002968744.1	COG0210 Superfamily I DNA and RNA helicases
YP_002968745.1	COG0210 Superfamily I DNA and RNA helicases
YP_002968746.1	COG0515 Serine/threonine protein kinase
YP_002968747.1	COG2931 RTX toxins and related Ca2+-binding proteins
YP_002968748.1	COG0714 MoxR-like ATPases
YP_002968749.1	COG1721 Uncharacterized conserved protein (somemembers contain a von Willebrand factor type A (vWAdomain))
YP_002968750.1	COG1305 Transglutaminase-like enzymes, putative cysteine proteases
YP_002968752.1	COG1716 FOG: FHA domain
YP_002968753.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_002968754.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_002968756.1	COG1194 A/G-specific DNA glycosylase
YP_002968757.1	COG0219 Predicted rRNA methylase (SpoU class))
YP_002968758.1	COG2848 Uncharacterized conserved protein
YP_002968759.1	ACT domain-containing protein
YP_002968760.1	COG3764 Sortase (surface protein transpeptidase)
YP_002968762.1	COG0153 Galactokinase
YP_002968763.1	COG1085 Galactose-1-phosphate uridylyltransferase
YP_002968764.1	COG1349 Transcriptional regulators of sugar metabolism
YP_002968765.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002968766.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_002968767.1	COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family
YP_002968768.1	COG0744 Membrane carboxypeptidase (penicillin-binding protein)
YP_002968769.1	COG0664 cAMP-binding proteins - catabolite geneactivator and regulatory subunit of cAMP-dependent protein kinases
YP_002968770.1	COG0095 Lipoate-protein ligase A
YP_002968771.1	COG2314 Predicted membrane protein
YP_002968773.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_002968774.1	COG1770 Protease II
YP_002968775.1	COG4850 Uncharacterized conserved protein
YP_002968776.1	COG0509 Glycine cleavage system H protein (lipoate-binding)
YP_002968777.1	COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding
YP_002968778.1	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
YP_002968780.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_002968781.1	COG3583 Uncharacterized protein conserved in bacteria
YP_002968782.1	COG2148 Sugar transferases involved inlipopolysaccharide synthesis
YP_002968784.1	COG4713 Predicted membrane protein
YP_002968785.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002968787.1	COG1209 dTDP-glucose pyrophosphorylase
YP_002968788.1	COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes
YP_002968789.1	COG1088 dTDP-D-glucose 4,6-dehydratase
YP_002968790.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002968791.1	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
YP_002968792.1	COG1216 Predicted glycosyltransferases
YP_002968793.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002968795.1	COG1216 Predicted glycosyltransferases
YP_002968797.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002968799.1	COG1004 Predicted UDP-glucose 6-dehydrogenase
YP_002968800.1	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
YP_002968802.1	COG1216 Predicted glycosyltransferases
YP_002968803.1	COG2148 Sugar transferases involved inlipopolysaccharide synthesis
YP_002968805.1	COG0477 Permeases of the major facilitator superfamily
YP_002968806.1	COG1914 Mn2+ and Fe2+ transporters of the NRAMP family
YP_002968808.1	with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate
YP_002968809.1	with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate
YP_002968810.1	COG0451 Nucleoside-diphosphate-sugar epimerases
YP_002968811.1	COG0707 UDP-N-acetylglucosamine: LPSN-acetylglucosamine transferase
YP_002968812.1	COG5017 Uncharacterized conserved protein
YP_002968813.1	COG1216 Predicted glycosyltransferases
YP_002968814.1	COG1216 Predicted glycosyltransferases
YP_002968816.1	COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components
YP_002968817.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
YP_002968818.1	COG0424 Nucleotide-binding protein implicated in inhibition of septum formation
YP_002968819.1	COG0394 Protein-tyrosine-phosphatase
YP_002968821.1	COG3944 Capsular polysaccharide biosynthesis protein
YP_002968824.1	COG3464 Transposase and in activated derivatives
YP_002968825.1	COG0083 Homoserine kinase
YP_002968826.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_002968827.1	COG0019 Diaminopimelate decarboxylase
YP_002968828.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_002968829.1	COG5520 O-Glycosyl hydrolase
YP_002968830.1	COG0251 Putative translation initiation inhibitor, yjgF family
YP_002968831.1	COG0395 ABC-type sugar transport system, permease component
YP_002968832.1	COG3459 Cellobiose phosphorylase
YP_002968833.1	COG3118 Thioredoxin domain-containing protein
YP_002968836.1	COG0545 FKBP-type peptidyl-prolyl cis-transisomerases 1
YP_002968837.1	COG1637 Predicted nuclease of the RecB family
YP_002968838.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex
YP_002968839.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_002968840.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_002968841.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_002968842.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_002968843.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_002968844.1	COG0636 F0F1-type ATP synthase, subunitc/Archaeal/vacuolar-type H+-ATPase, subunit K
YP_002968845.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_002968846.1	catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_002968847.1	COG0477 Permeases of the major facilitator superfamily
YP_002968848.1	COG1957 Inosine-uridine nucleoside N-ribohydrolase
YP_002968852.1	COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
YP_002968853.1	COG1536 Flagellar motor switch protein
YP_002968855.1	COG1479 Uncharacterized conserved protein
YP_002968857.1	COG0582 Integrase
YP_002968858.1	catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA
YP_002968859.1	COG2730 Endoglucanase
YP_002968861.1	COG0679 Predicted permeases
YP_002968862.1	COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome, glyoxylate carboligase, phosphonopyruvatedecarboxylase)]
YP_002968863.1	COG0028 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome, glyoxylate carboligase, phosphonopyruvatedecarboxylase)]
YP_002968864.1	COG0038 Chloride channel protein EriC
YP_002968865.1	COG4932 Predicted outer membrane protein
YP_002968867.1	COG0366 Glycosidases
YP_002968868.1	COG0221 Inorganic pyrophosphatase
YP_002968870.1	COG0745 Response regulators consisting of aCheY-like receiver domain and a winged-helix DNA-binding domain
YP_002968871.1	COG0177 Predicted EndoIII-related endonuclease
YP_002968873.1	COG0747 ABC-type dipeptide transport system, periplasmic component
YP_002968874.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_002968875.1	COG1522 Transcriptional regulators
YP_002968876.1	catalyzes the interconversion of chorismate to prephenate
YP_002968878.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_002968879.1	COG1232 Protoporphyrinogen oxidase
YP_002968881.1	COG1670 Acetyltransferases, including N-acetylasesof ribosomal proteins
YP_002968882.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_002968883.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_002968884.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_002968886.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002968887.1	COG0566 rRNA methylases
YP_002968888.1	COG0461 Orotate phosphoribosyltransferase
YP_002968889.1	COG2217 Cation transport ATPase
YP_002968890.1	COG0542 ATPases with chaperone activity, ATP-binding subunit
YP_002968891.1	COG0179 2-keto-4-pentenoatehydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
YP_002968895.1	COG3764 Sortase (surface protein transpeptidase)
YP_002968896.1	COG0325 Predicted enzyme with a TIM-barrel fold
YP_002968897.1	COG0008 Glutamyl- and glutaminyl-tRNA synthetases
YP_002968899.1	COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
YP_002968904.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_002968905.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_002968906.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_002968907.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_002968908.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_002968909.1	COG0524 Sugar kinases, ribokinase family
YP_002968910.1	COG0477 Permeases of the major facilitator superfamily
YP_002968911.1	COG1957 Inosine-uridine nucleoside N-ribohydrolase
YP_002968912.1	COG1609 Transcriptional regulators
YP_002968913.1	COG0562 UDP-galactopyranose mutase
YP_002968914.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002968916.1	COG1216 Predicted glycosyltransferases
YP_002968917.1	COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
YP_002968919.1	COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
YP_002968920.1	COG1216 Predicted glycosyltransferases
YP_002968921.1	COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase)
YP_002968922.1	COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase)
YP_002968923.1	COG3328 Transposase and inactivated derivatives
YP_002968924.1	COG4886 Leucine-rich repeat (LRR protein)
YP_002968928.1	COG1134 ABC-type polysaccharide/polyol phosphatetransport system, ATPase component
YP_002968929.1	COG1682 ABC-type polysaccharide/polyol phosphateexport systems, permease component
YP_002968930.1	COG1216 Predicted glycosyltransferases
YP_002968935.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002968936.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002968937.1	COG1418 Predicted HD superfamily hydrolase
YP_002968938.1	COG0121 Predicted glutamine amidotransferase
YP_002968939.1	COG3158 K+ transporter
YP_002968940.1	COG0084 Mg-dependent DNase
YP_002968941.1	COG3345 Alpha-galactosidase
YP_002968943.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002968944.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002968946.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_002968949.1	COG0313 Predicted methyltransferases
YP_002968950.1	COG1928 Dolichyl-phosphate-mannose--proteinO-mannosyl transferase
YP_002968951.1	COG0657 Esterase/lipase
YP_002968952.1	COG0586 Uncharacterized membrane-associated protein
YP_002968953.1	COG4832 Uncharacterized conserved protein
YP_002968954.1	COG1472 Beta-glucosidase-related glycosidases
YP_002968955.1	COG1309 Transcriptional regulator
YP_002968956.1	COG0637 Predicted phosphatase/phosphohexomutase
YP_002968957.1	COG0789 Predicted transcriptional regulators
YP_002968958.1	COG2214 DnaJ-class molecular chaperone
YP_002968959.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_002968960.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_002968962.1	COG1609 Transcriptional regulators
YP_002968964.1	COG1011 Predicted hydrolase (HAD superfamily)
YP_002968965.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
YP_002968966.1	COG0395 ABC-type sugar transport system, permease component
YP_002968967.1	COG1175 ABC-type sugar transport systems, permease components
YP_002968968.1	COG2182 Maltose-binding periplasmic proteins/domains
YP_002968969.1	COG0366 Glycosidases
YP_002968970.1	COG1640 4-alpha-glucanotransferase
YP_002968972.1	COG0395 ABC-type sugar transport system, permease component
YP_002968973.1	COG1175 ABC-type sugar transport systems, permease components
YP_002968974.1	COG1609 Transcriptional regulators
YP_002968975.1	COG1653 ABC-type sugar transport system, periplasmic component
YP_002968976.1	COG0366 Glycosidases
YP_002968977.1	COG0406 Fructose-2,6-bisphosphatase
YP_002968979.1	COG0778 Nitroreductase
YP_002968981.1	COG0477 Permeases of the major facilitator superfamily
YP_002968982.1	COG0388 Predicted amidohydrolase
YP_002968983.1	COG0388 Predicted amidohydrolase
YP_002968984.1	COG3077 DNA-damage-inducible protein J
YP_002968985.1	COG2211 Na+/melibiose symporter and related transporters
YP_002968986.1	COG3533 Uncharacterized protein conserved in bacteria
YP_002968987.1	COG1609 Transcriptional regulators
YP_002968988.1	COG0846 NAD-dependent protein deacetylases, SIR2family
YP_002968989.1	catalyzes the formation of 2-oxobutanoate from L-threonine
YP_002968990.1	COG0366 Glycosidases
YP_002968993.1	COG3345 Alpha-galactosidase
YP_002968994.1	COG0395 ABC-type sugar transport system, permease component
YP_002968995.1	COG1175 ABC-type sugar transport systems, permease components
YP_002968996.1	COG1653 ABC-type sugar transport system, periplasmic component
YP_002968997.1	COG1940 Transcriptional regulator/sugar kinase
YP_002968998.1	COG3345 Alpha-galactosidase
YP_002968999.1	COG0590 Cytosine/adenosine deaminases
YP_002969000.1	COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
YP_002969001.1	COG0400 Predicted esterase
YP_002969003.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_002969004.1	COG0474 Cation transport ATPase
YP_002969005.1	COG0566 rRNA methylases
YP_002969006.1	COG0515 Serine/threonine protein kinase
YP_002969007.1	COG3839 ABC-type sugar transport systems, ATPase components
YP_002969008.1	COG1226 Kef-type K+ transport systems, predictedNAD-binding component
YP_002969009.1	COG0515 Serine/threonine protein kinase
YP_002969010.1	COG1651 Protein-disulfide isomerase
YP_002969011.1	COG3583 Uncharacterized protein conserved in bacteria
YP_002969012.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_002969013.1	COG0030 Dimethyladenosine transferase (rRNAmethylation)
YP_002969015.1	COG0617 tRNA nucleotidyltransferase/poly(Apolymerase)
YP_002969016.1	COG0494 NTP pyrophosphohydrolases includingoxidative damage repair enzymes
YP_002969018.1	COG0728 Uncharacterized membrane protein, putativevirulence factor
YP_002969019.1	COG0492 Thioredoxin reductase
YP_002969020.1	COG1475 Predicted transcriptional regulators
YP_002969021.1	COG1192 ATPases involved in chromosomepartitioning
YP_002969022.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_002969023.1	COG1847 Predicted RNA-binding protein
YP_002969024.1	COG0706 Preprotein translocase subunit YidC
YP_002969025.1	COG0759 Uncharacterized conserved protein
YP_002969026.1	COG0594 RNase P protein component
YP_002969027.1	in Escherichia coli transcription of this gene is enhanced by polyamines