-- dump date 20140619_002023 -- class Genbank::misc_feature -- table misc_feature_note -- id note 580050000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 580050000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050000003 Walker A motif; other site 580050000004 ATP binding site [chemical binding]; other site 580050000005 Walker B motif; other site 580050000006 arginine finger; other site 580050000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 580050000008 DnaA box-binding interface [nucleotide binding]; other site 580050000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 580050000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 580050000011 putative DNA binding surface [nucleotide binding]; other site 580050000012 dimer interface [polypeptide binding]; other site 580050000013 beta-clamp/clamp loader binding surface; other site 580050000014 beta-clamp/translesion DNA polymerase binding surface; other site 580050000015 recombination protein F; Reviewed; Region: recF; PRK00064 580050000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000017 Walker A/P-loop; other site 580050000018 ATP binding site [chemical binding]; other site 580050000019 Q-loop/lid; other site 580050000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000021 ABC transporter signature motif; other site 580050000022 Walker B; other site 580050000023 D-loop; other site 580050000024 H-loop/switch region; other site 580050000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 580050000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 580050000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580050000028 Mg2+ binding site [ion binding]; other site 580050000029 G-X-G motif; other site 580050000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 580050000031 anchoring element; other site 580050000032 dimer interface [polypeptide binding]; other site 580050000033 ATP binding site [chemical binding]; other site 580050000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 580050000035 active site 580050000036 putative metal-binding site [ion binding]; other site 580050000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 580050000038 DNA gyrase subunit A; Validated; Region: PRK05560 580050000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 580050000040 CAP-like domain; other site 580050000041 active site 580050000042 primary dimer interface [polypeptide binding]; other site 580050000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580050000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580050000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580050000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580050000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580050000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 580050000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 580050000050 VanZ like family; Region: VanZ; cl01971 580050000051 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 580050000052 Haemolysin-III related; Region: HlyIII; pfam03006 580050000053 glutamate dehydrogenase; Provisional; Region: PRK09414 580050000054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 580050000055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 580050000056 NAD(P) binding site [chemical binding]; other site 580050000057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050000059 putative substrate translocation pore; other site 580050000060 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 580050000061 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 580050000062 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 580050000063 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 580050000064 Protein of unknown function DUF45; Region: DUF45; pfam01863 580050000065 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 580050000066 MarR family; Region: MarR_2; pfam12802 580050000067 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 580050000068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 580050000069 non-specific DNA interactions [nucleotide binding]; other site 580050000070 DNA binding site [nucleotide binding] 580050000071 sequence specific DNA binding site [nucleotide binding]; other site 580050000072 putative cAMP binding site [chemical binding]; other site 580050000073 6-phosphogluconolactonase; Provisional; Region: PRK11028 580050000074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000075 Walker A/P-loop; other site 580050000076 ATP binding site [chemical binding]; other site 580050000077 Q-loop/lid; other site 580050000078 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 580050000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000080 ABC transporter signature motif; other site 580050000081 Walker B; other site 580050000082 D-loop; other site 580050000083 H-loop/switch region; other site 580050000084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000085 Walker A/P-loop; other site 580050000086 ATP binding site [chemical binding]; other site 580050000087 Q-loop/lid; other site 580050000088 ABC transporter signature motif; other site 580050000089 Walker B; other site 580050000090 D-loop; other site 580050000091 H-loop/switch region; other site 580050000092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580050000093 S-adenosylmethionine binding site [chemical binding]; other site 580050000094 Predicted flavoprotein [General function prediction only]; Region: COG0431 580050000095 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 580050000096 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 580050000097 homodimer interface [polypeptide binding]; other site 580050000098 chemical substrate binding site [chemical binding]; other site 580050000099 oligomer interface [polypeptide binding]; other site 580050000100 metal binding site [ion binding]; metal-binding site 580050000101 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 580050000102 GIY-YIG motif/motif A; other site 580050000103 active site 580050000104 catalytic site [active] 580050000105 Helix-turn-helix domain; Region: HTH_17; pfam12728 580050000106 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 580050000107 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 580050000108 cofactor binding site; other site 580050000109 DNA binding site [nucleotide binding] 580050000110 substrate interaction site [chemical binding]; other site 580050000111 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 580050000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 580050000113 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 580050000114 PemK-like protein; Region: PemK; pfam02452 580050000115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 580050000116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 580050000117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 580050000118 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 580050000119 catalytic tetrad [active] 580050000120 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 580050000121 active site 580050000122 catalytic tetrad [active] 580050000123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 580050000124 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 580050000125 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 580050000126 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 580050000127 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 580050000128 potential frameshift: common BLAST hit:gi|116630082|ref|YP_815254.1| aminoglycosidephosphotransferase 580050000129 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 580050000130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 580050000131 Transposase; Region: DDE_Tnp_ISL3; pfam01610 580050000132 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 580050000133 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 580050000134 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 580050000135 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 580050000136 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 580050000137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050000138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050000139 putative substrate translocation pore; other site 580050000140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 580050000141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 580050000142 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 580050000143 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 580050000144 dimerization interface [polypeptide binding]; other site 580050000145 DPS ferroxidase diiron center [ion binding]; other site 580050000146 ion pore; other site 580050000147 Domain of unknown function DUF21; Region: DUF21; pfam01595 580050000148 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 580050000149 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 580050000150 Transporter associated domain; Region: CorC_HlyC; smart01091 580050000151 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 580050000152 active site clefts [active] 580050000153 zinc binding site [ion binding]; other site 580050000154 dimer interface [polypeptide binding]; other site 580050000155 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050000156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050000157 DNA binding site [nucleotide binding] 580050000158 domain linker motif; other site 580050000159 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 580050000160 ligand binding site [chemical binding]; other site 580050000161 dimerization interface (open form) [polypeptide binding]; other site 580050000162 dimerization interface (closed form) [polypeptide binding]; other site 580050000163 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 580050000164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000165 ABC transporter; Region: ABC_tran; pfam00005 580050000166 Q-loop/lid; other site 580050000167 ABC transporter signature motif; other site 580050000168 Walker B; other site 580050000169 D-loop; other site 580050000170 H-loop/switch region; other site 580050000171 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050000172 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050000173 DNA binding site [nucleotide binding] 580050000174 domain linker motif; other site 580050000175 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 580050000176 ligand binding site [chemical binding]; other site 580050000177 dimerization interface [polypeptide binding]; other site 580050000178 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 580050000179 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 580050000180 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 580050000181 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 580050000182 putative N- and C-terminal domain interface [polypeptide binding]; other site 580050000183 putative active site [active] 580050000184 MgATP binding site [chemical binding]; other site 580050000185 catalytic site [active] 580050000186 metal binding site [ion binding]; metal-binding site 580050000187 putative carbohydrate binding site [chemical binding]; other site 580050000188 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 580050000189 intersubunit interface [polypeptide binding]; other site 580050000190 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 580050000191 active site 580050000192 Zn2+ binding site [ion binding]; other site 580050000193 L-arabinose isomerase; Provisional; Region: PRK02929 580050000194 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 580050000195 hexamer (dimer of trimers) interface [polypeptide binding]; other site 580050000196 trimer interface [polypeptide binding]; other site 580050000197 substrate binding site [chemical binding]; other site 580050000198 Mn binding site [ion binding]; other site 580050000199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 580050000200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 580050000201 active site 580050000202 catalytic tetrad [active] 580050000203 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 580050000204 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 580050000205 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 580050000206 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 580050000207 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 580050000208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 580050000209 Transposase; Region: DDE_Tnp_ISL3; pfam01610 580050000210 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 580050000211 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 580050000212 active site 580050000213 HIGH motif; other site 580050000214 dimer interface [polypeptide binding]; other site 580050000215 KMSKS motif; other site 580050000216 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 580050000217 homodimer interface [polypeptide binding]; other site 580050000218 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 580050000219 active site pocket [active] 580050000220 Rhomboid family; Region: Rhomboid; pfam01694 580050000221 Methyltransferase domain; Region: Methyltransf_26; pfam13659 580050000222 putative septation inhibitor protein; Reviewed; Region: PRK02251 580050000223 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 580050000224 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 580050000225 active site 580050000226 catalytic site [active] 580050000227 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 580050000228 Glutamine amidotransferase class-I; Region: GATase; pfam00117 580050000229 glutamine binding [chemical binding]; other site 580050000230 catalytic triad [active] 580050000231 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 580050000232 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 580050000233 active site 580050000234 ATP binding site [chemical binding]; other site 580050000235 substrate binding site [chemical binding]; other site 580050000236 activation loop (A-loop); other site 580050000237 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 580050000238 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 580050000239 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 580050000240 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 580050000241 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 580050000242 Catalytic domain of Protein Kinases; Region: PKc; cd00180 580050000243 active site 580050000244 ATP binding site [chemical binding]; other site 580050000245 substrate binding site [chemical binding]; other site 580050000246 activation loop (A-loop); other site 580050000247 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 580050000248 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 580050000249 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 580050000250 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 580050000251 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 580050000252 active site 580050000253 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 580050000254 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 580050000255 phosphopeptide binding site; other site 580050000256 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 580050000257 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 580050000258 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 580050000259 phosphopeptide binding site; other site 580050000260 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 580050000261 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 580050000262 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 580050000263 EamA-like transporter family; Region: EamA; pfam00892 580050000264 EamA-like transporter family; Region: EamA; pfam00892 580050000265 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 580050000266 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 580050000267 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 580050000268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580050000269 S-adenosylmethionine binding site [chemical binding]; other site 580050000270 Predicted membrane protein [Function unknown]; Region: COG2261 580050000271 ferredoxin-NADP+ reductase; Region: PLN02852 580050000272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 580050000273 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 580050000274 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 580050000275 Soluble P-type ATPase [General function prediction only]; Region: COG4087 580050000276 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 580050000277 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 580050000278 protein binding site [polypeptide binding]; other site 580050000279 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 580050000280 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 580050000281 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 580050000282 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 580050000283 heat shock protein HtpX; Provisional; Region: PRK03072 580050000284 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 580050000285 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 580050000286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050000287 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050000288 putative substrate translocation pore; other site 580050000289 RelB antitoxin; Region: RelB; cl01171 580050000290 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 580050000291 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 580050000292 DNA binding site [nucleotide binding] 580050000293 active site 580050000294 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 580050000295 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 580050000296 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 580050000297 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 580050000298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 580050000299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 580050000300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 580050000301 dimerization interface [polypeptide binding]; other site 580050000302 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 580050000303 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 580050000304 active site 580050000305 catalytic tetrad [active] 580050000306 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 580050000307 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 580050000308 FAD binding pocket [chemical binding]; other site 580050000309 conserved FAD binding motif [chemical binding]; other site 580050000310 phosphate binding motif [ion binding]; other site 580050000311 beta-alpha-beta structure motif; other site 580050000312 NAD binding pocket [chemical binding]; other site 580050000313 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 580050000314 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 580050000315 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 580050000316 DNA binding residues [nucleotide binding] 580050000317 putative dimer interface [polypeptide binding]; other site 580050000318 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 580050000319 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 580050000320 NADH(P)-binding; Region: NAD_binding_10; pfam13460 580050000321 NAD(P) binding site [chemical binding]; other site 580050000322 putative active site [active] 580050000323 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 580050000324 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 580050000325 catalytic Zn binding site [ion binding]; other site 580050000326 NAD(P) binding site [chemical binding]; other site 580050000327 structural Zn binding site [ion binding]; other site 580050000328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 580050000329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 580050000330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 580050000331 dimerization interface [polypeptide binding]; other site 580050000332 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 580050000333 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 580050000334 NodB motif; other site 580050000335 active site 580050000336 catalytic site [active] 580050000337 metal binding site [ion binding]; metal-binding site 580050000338 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 580050000339 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 580050000340 active site 580050000341 intersubunit interface [polypeptide binding]; other site 580050000342 zinc binding site [ion binding]; other site 580050000343 Na+ binding site [ion binding]; other site 580050000344 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 580050000345 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 580050000346 GDP-binding site [chemical binding]; other site 580050000347 ACT binding site; other site 580050000348 IMP binding site; other site 580050000349 CrcB-like protein; Region: CRCB; pfam02537 580050000350 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 580050000351 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 580050000352 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 580050000353 TM-ABC transporter signature motif; other site 580050000354 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 580050000355 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 580050000356 TM-ABC transporter signature motif; other site 580050000357 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 580050000358 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 580050000359 Walker A/P-loop; other site 580050000360 ATP binding site [chemical binding]; other site 580050000361 Q-loop/lid; other site 580050000362 ABC transporter signature motif; other site 580050000363 Walker B; other site 580050000364 D-loop; other site 580050000365 H-loop/switch region; other site 580050000366 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 580050000367 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 580050000368 Walker A/P-loop; other site 580050000369 ATP binding site [chemical binding]; other site 580050000370 Q-loop/lid; other site 580050000371 ABC transporter signature motif; other site 580050000372 Walker B; other site 580050000373 D-loop; other site 580050000374 H-loop/switch region; other site 580050000375 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 580050000376 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 580050000377 ligand binding site [chemical binding]; other site 580050000378 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050000379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050000380 DNA binding site [nucleotide binding] 580050000381 domain linker motif; other site 580050000382 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 580050000383 sucrose phosphorylase; Provisional; Region: PRK13840 580050000384 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 580050000385 active site 580050000386 homodimer interface [polypeptide binding]; other site 580050000387 catalytic site [active] 580050000388 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 580050000389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050000390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050000391 putative substrate translocation pore; other site 580050000392 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 580050000393 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 580050000394 ligand binding site [chemical binding]; other site 580050000395 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 580050000396 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 580050000397 ATP-grasp domain; Region: ATP-grasp_4; cl17255 580050000398 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 580050000399 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 580050000400 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 580050000401 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 580050000402 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 580050000403 metabolite-proton symporter; Region: 2A0106; TIGR00883 580050000404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050000405 putative substrate translocation pore; other site 580050000406 ketol-acid reductoisomerase; Provisional; Region: PRK05479 580050000407 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 580050000408 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 580050000409 Domain of unknown function (DUF303); Region: DUF303; pfam03629 580050000410 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 580050000411 active site 580050000412 catalytic triad [active] 580050000413 oxyanion hole [active] 580050000414 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 580050000415 beta-galactosidase; Region: BGL; TIGR03356 580050000416 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050000417 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050000418 DNA binding site [nucleotide binding] 580050000419 domain linker motif; other site 580050000420 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 580050000421 ligand binding site [chemical binding]; other site 580050000422 dimerization interface [polypeptide binding]; other site 580050000423 Protein of unknown function, DUF624; Region: DUF624; pfam04854 580050000424 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 580050000425 putative active cleft [active] 580050000426 dimerization interface [polypeptide binding]; other site 580050000427 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 580050000428 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000429 Walker A/P-loop; other site 580050000430 ATP binding site [chemical binding]; other site 580050000431 Q-loop/lid; other site 580050000432 ABC transporter signature motif; other site 580050000433 Walker B; other site 580050000434 D-loop; other site 580050000435 H-loop/switch region; other site 580050000436 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 580050000437 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 580050000438 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 580050000439 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 580050000440 Walker A/P-loop; other site 580050000441 ATP binding site [chemical binding]; other site 580050000442 Q-loop/lid; other site 580050000443 ABC transporter signature motif; other site 580050000444 Walker B; other site 580050000445 D-loop; other site 580050000446 H-loop/switch region; other site 580050000447 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 580050000448 FtsX-like permease family; Region: FtsX; pfam02687 580050000449 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 580050000450 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 580050000451 potential frameshift: common BLAST hit: gi|219683212|ref|YP_002469595.1| putative ABC transport system integral membrane protein 580050000452 potential frameshift: common BLAST hit: gi|219683212|ref|YP_002469595.1| putative ABC transport system integral membrane protein 580050000453 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 580050000454 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 580050000455 FtsX-like permease family; Region: FtsX; pfam02687 580050000456 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000457 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 580050000458 ABC transporter signature motif; other site 580050000459 Walker B; other site 580050000460 D-loop; other site 580050000461 H-loop/switch region; other site 580050000462 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 580050000463 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 580050000464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 580050000465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000466 Walker A/P-loop; other site 580050000467 ATP binding site [chemical binding]; other site 580050000468 Q-loop/lid; other site 580050000469 ABC transporter signature motif; other site 580050000470 Walker B; other site 580050000471 D-loop; other site 580050000472 H-loop/switch region; other site 580050000473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 580050000474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 580050000475 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 580050000476 Walker A/P-loop; other site 580050000477 ATP binding site [chemical binding]; other site 580050000478 Q-loop/lid; other site 580050000479 ABC transporter signature motif; other site 580050000480 Walker B; other site 580050000481 D-loop; other site 580050000482 H-loop/switch region; other site 580050000483 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 580050000484 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 580050000485 NodB motif; other site 580050000486 active site 580050000487 catalytic site [active] 580050000488 metal binding site [ion binding]; metal-binding site 580050000489 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 580050000490 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 580050000491 active site 580050000492 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 580050000493 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 580050000494 active site 580050000495 substrate binding site [chemical binding]; other site 580050000496 trimer interface [polypeptide binding]; other site 580050000497 CoA binding site [chemical binding]; other site 580050000498 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 580050000499 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 580050000500 ligand binding site [chemical binding]; other site 580050000501 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 580050000502 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 580050000503 Predicted membrane protein [Function unknown]; Region: COG1511 580050000504 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 580050000505 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 580050000506 Predicted membrane protein [Function unknown]; Region: COG1511 580050000507 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 580050000508 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 580050000509 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 580050000510 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 580050000511 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 580050000512 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 580050000513 Walker A/P-loop; other site 580050000514 ATP binding site [chemical binding]; other site 580050000515 Q-loop/lid; other site 580050000516 ABC transporter signature motif; other site 580050000517 Walker B; other site 580050000518 D-loop; other site 580050000519 H-loop/switch region; other site 580050000520 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050000521 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 580050000522 Walker A/P-loop; other site 580050000523 ATP binding site [chemical binding]; other site 580050000524 Q-loop/lid; other site 580050000525 ABC transporter signature motif; other site 580050000526 Walker B; other site 580050000527 D-loop; other site 580050000528 H-loop/switch region; other site 580050000529 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 580050000530 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 580050000531 intersubunit interface [polypeptide binding]; other site 580050000532 YodA lipocalin-like domain; Region: YodA; cl01365 580050000533 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 580050000534 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 580050000535 active site 580050000536 nucleophile elbow; other site 580050000537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 580050000538 Peptidase family C69; Region: Peptidase_C69; pfam03577 580050000539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 580050000540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 580050000541 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 580050000542 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 580050000543 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 580050000544 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 580050000545 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 580050000546 Nitrogen regulatory protein P-II; Region: P-II; smart00938 580050000547 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 580050000548 metal binding triad; other site 580050000549 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 580050000550 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 580050000551 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 580050000552 sequence-specific DNA binding site [nucleotide binding]; other site 580050000553 salt bridge; other site 580050000554 replicative DNA helicase; Region: DnaB; TIGR00665 580050000555 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 580050000556 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 580050000557 Walker A motif; other site 580050000558 ATP binding site [chemical binding]; other site 580050000559 Walker B motif; other site 580050000560 DNA binding loops [nucleotide binding] 580050000561 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580050000562 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 580050000563 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 580050000564 catalytic triad [active] 580050000565 Uncharacterized conserved protein [Function unknown]; Region: COG3937 580050000566 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 580050000567 ABC1 family; Region: ABC1; cl17513 580050000568 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 580050000569 active site 580050000570 catalytic site [active] 580050000571 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 580050000572 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 580050000573 active site 580050000574 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 580050000575 active site 580050000576 Ap6A binding site [chemical binding]; other site 580050000577 nudix motif; other site 580050000578 metal binding site [ion binding]; metal-binding site 580050000579 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050000580 catalytic core [active] 580050000581 polyphosphate kinase; Provisional; Region: PRK05443 580050000582 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 580050000583 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 580050000584 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 580050000585 putative domain interface [polypeptide binding]; other site 580050000586 putative active site [active] 580050000587 catalytic site [active] 580050000588 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 580050000589 putative domain interface [polypeptide binding]; other site 580050000590 putative active site [active] 580050000591 catalytic site [active] 580050000592 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 580050000593 Type II/IV secretion system protein; Region: T2SE; pfam00437 580050000594 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 580050000595 Walker B motif; other site 580050000596 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 580050000597 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 580050000598 TadE-like protein; Region: TadE; pfam07811 580050000599 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 580050000600 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050000601 Walker A motif; other site 580050000602 ATP binding site [chemical binding]; other site 580050000603 Walker B motif; other site 580050000604 arginine finger; other site 580050000605 recombination protein RecR; Reviewed; Region: recR; PRK00076 580050000606 RecR protein; Region: RecR; pfam02132 580050000607 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 580050000608 putative active site [active] 580050000609 putative metal-binding site [ion binding]; other site 580050000610 tetramer interface [polypeptide binding]; other site 580050000611 aspartate kinase; Reviewed; Region: PRK06635 580050000612 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 580050000613 putative nucleotide binding site [chemical binding]; other site 580050000614 putative catalytic residues [active] 580050000615 putative Mg ion binding site [ion binding]; other site 580050000616 putative aspartate binding site [chemical binding]; other site 580050000617 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 580050000618 putative allosteric regulatory site; other site 580050000619 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 580050000620 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 580050000621 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 580050000622 2-isopropylmalate synthase; Validated; Region: PRK03739 580050000623 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 580050000624 active site 580050000625 catalytic residues [active] 580050000626 metal binding site [ion binding]; metal-binding site 580050000627 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 580050000628 Transglycosylase; Region: Transgly; pfam00912 580050000629 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 580050000630 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 580050000631 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 580050000632 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 580050000633 PAP2 superfamily; Region: PAP2; pfam01569 580050000634 active site 580050000635 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 580050000636 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 580050000637 active site 580050000638 interdomain interaction site; other site 580050000639 putative metal-binding site [ion binding]; other site 580050000640 nucleotide binding site [chemical binding]; other site 580050000641 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 580050000642 domain I; other site 580050000643 phosphate binding site [ion binding]; other site 580050000644 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 580050000645 domain II; other site 580050000646 domain III; other site 580050000647 nucleotide binding site [chemical binding]; other site 580050000648 DNA binding groove [nucleotide binding] 580050000649 catalytic site [active] 580050000650 domain IV; other site 580050000651 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 580050000652 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 580050000653 thymidylate kinase; Validated; Region: tmk; PRK00698 580050000654 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 580050000655 TMP-binding site; other site 580050000656 ATP-binding site [chemical binding]; other site 580050000657 DNA polymerase III subunit delta'; Validated; Region: PRK07940 580050000658 DNA polymerase III subunit delta'; Validated; Region: PRK08485 580050000659 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 580050000660 substrate binding site [chemical binding]; other site 580050000661 Peptidase family C69; Region: Peptidase_C69; pfam03577 580050000662 Peptidase family C69; Region: Peptidase_C69; pfam03577 580050000663 AAA domain; Region: AAA_14; pfam13173 580050000664 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 580050000665 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 580050000666 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 580050000667 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 580050000668 putative active site [active] 580050000669 Predicted membrane protein [Function unknown]; Region: COG2246 580050000670 GtrA-like protein; Region: GtrA; pfam04138 580050000671 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050000672 catalytic core [active] 580050000673 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050000674 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050000675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 580050000676 Transposase; Region: DDE_Tnp_ISL3; pfam01610 580050000677 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 580050000678 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 580050000679 active site 580050000680 HIGH motif; other site 580050000681 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 580050000682 active site 580050000683 KMSKS motif; other site 580050000684 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 580050000685 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 580050000686 putative active site [active] 580050000687 putative metal binding site [ion binding]; other site 580050000688 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 580050000689 Transcriptional regulator [Transcription]; Region: IclR; COG1414 580050000690 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 580050000691 Bacterial transcriptional regulator; Region: IclR; pfam01614 580050000692 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 580050000693 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 580050000694 substrate binding site [chemical binding]; other site 580050000695 ligand binding site [chemical binding]; other site 580050000696 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 580050000697 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 580050000698 substrate binding site [chemical binding]; other site 580050000699 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 580050000700 AsnC family; Region: AsnC_trans_reg; pfam01037 580050000701 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 580050000702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 580050000703 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 580050000704 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 580050000705 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 580050000706 hinge; other site 580050000707 active site 580050000708 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 580050000709 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 580050000710 putative acyl-acceptor binding pocket; other site 580050000711 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 580050000712 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 580050000713 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 580050000714 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 580050000715 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 580050000716 ATP-grasp domain; Region: ATP-grasp_4; cl17255 580050000717 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 580050000718 CAAX protease self-immunity; Region: Abi; pfam02517 580050000719 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 580050000720 Mechanosensitive ion channel; Region: MS_channel; pfam00924 580050000721 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 580050000722 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 580050000723 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 580050000724 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 580050000725 nucleophilic elbow; other site 580050000726 catalytic triad; other site 580050000727 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 580050000728 Predicted membrane protein [Function unknown]; Region: COG4905 580050000729 aspartate aminotransferase; Provisional; Region: PRK06836 580050000730 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050000731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050000732 homodimer interface [polypeptide binding]; other site 580050000733 catalytic residue [active] 580050000734 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 580050000735 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580050000736 binding surface 580050000737 TPR motif; other site 580050000738 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 580050000739 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 580050000740 substrate binding site [chemical binding]; other site 580050000741 ATP binding site [chemical binding]; other site 580050000742 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 580050000743 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 580050000744 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 580050000745 ssDNA binding site; other site 580050000746 generic binding surface II; other site 580050000747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580050000748 ATP binding site [chemical binding]; other site 580050000749 putative Mg++ binding site [ion binding]; other site 580050000750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050000751 nucleotide binding region [chemical binding]; other site 580050000752 ATP-binding site [chemical binding]; other site 580050000753 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 580050000754 metal ion-dependent adhesion site (MIDAS); other site 580050000755 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 580050000756 T surface-antigen of pili; Region: FctA; pfam12892 580050000757 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 580050000758 T surface-antigen of pili; Region: FctA; pfam12892 580050000759 T surface-antigen of pili; Region: FctA; pfam12892 580050000760 T surface-antigen of pili; Region: FctA; pfam12892 580050000761 T surface-antigen of pili; Region: FctA; pfam12892 580050000762 T surface-antigen of pili; Region: FctA; pfam12892 580050000763 T surface-antigen of pili; Region: FctA; pfam12892 580050000764 T surface-antigen of pili; Region: FctA; pfam12892 580050000765 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 580050000766 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 580050000767 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580050000768 S-adenosylmethionine binding site [chemical binding]; other site 580050000769 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 580050000770 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 580050000771 RimM N-terminal domain; Region: RimM; pfam01782 580050000772 PRC-barrel domain; Region: PRC; pfam05239 580050000773 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 580050000774 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 580050000775 G-X-X-G motif; other site 580050000776 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 580050000777 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 580050000778 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 580050000779 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 580050000780 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 580050000781 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 580050000782 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 580050000783 putative catalytic site [active] 580050000784 putative metal binding site [ion binding]; other site 580050000785 putative phosphate binding site [ion binding]; other site 580050000786 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 580050000787 putative catalytic site [active] 580050000788 putative phosphate binding site [ion binding]; other site 580050000789 putative metal binding site [ion binding]; other site 580050000790 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 580050000791 Cation efflux family; Region: Cation_efflux; pfam01545 580050000792 signal recognition particle protein; Provisional; Region: PRK10867 580050000793 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 580050000794 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 580050000795 P loop; other site 580050000796 GTP binding site [chemical binding]; other site 580050000797 Signal peptide binding domain; Region: SRP_SPB; pfam02978 580050000798 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 580050000799 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 580050000800 active site 580050000801 HIGH motif; other site 580050000802 nucleotide binding site [chemical binding]; other site 580050000803 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 580050000804 KMSKS motif; other site 580050000805 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 580050000806 tRNA binding surface [nucleotide binding]; other site 580050000807 anticodon binding site; other site 580050000808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580050000809 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 580050000810 ABC transporter; Region: ABC_tran_2; pfam12848 580050000811 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580050000812 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 580050000813 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 580050000814 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 580050000815 catalytic triad [active] 580050000816 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 580050000817 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 580050000818 putative valine binding site [chemical binding]; other site 580050000819 dimer interface [polypeptide binding]; other site 580050000820 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 580050000821 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 580050000822 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 580050000823 PYR/PP interface [polypeptide binding]; other site 580050000824 dimer interface [polypeptide binding]; other site 580050000825 TPP binding site [chemical binding]; other site 580050000826 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 580050000827 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 580050000828 TPP-binding site [chemical binding]; other site 580050000829 dimer interface [polypeptide binding]; other site 580050000830 ribonuclease III; Reviewed; Region: rnc; PRK00102 580050000831 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 580050000832 dimerization interface [polypeptide binding]; other site 580050000833 active site 580050000834 metal binding site [ion binding]; metal-binding site 580050000835 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 580050000836 dsRNA binding site [nucleotide binding]; other site 580050000837 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 580050000838 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 580050000839 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 580050000840 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 580050000841 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 580050000842 active site 580050000843 (T/H)XGH motif; other site 580050000844 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 580050000845 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 580050000846 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 580050000847 active site 580050000848 catalytic tetrad [active] 580050000849 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 580050000850 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 580050000851 active site 580050000852 Ribonuclease PH; Region: RNase_PH_bact; cd11362 580050000853 ribonuclease PH; Reviewed; Region: rph; PRK00173 580050000854 hexamer interface [polypeptide binding]; other site 580050000855 active site 580050000856 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 580050000857 active site 580050000858 dimerization interface [polypeptide binding]; other site 580050000859 FemAB family; Region: FemAB; pfam02388 580050000860 Membrane transport protein; Region: Mem_trans; cl09117 580050000861 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 580050000862 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 580050000863 Substrate binding site; other site 580050000864 Cupin domain; Region: Cupin_2; cl17218 580050000865 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 580050000866 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 580050000867 active site 580050000868 dimer interface [polypeptide binding]; other site 580050000869 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 580050000870 dimer interface [polypeptide binding]; other site 580050000871 active site 580050000872 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 580050000873 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 580050000874 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 580050000875 Catalytic site [active] 580050000876 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 580050000877 RNA/DNA hybrid binding site [nucleotide binding]; other site 580050000878 active site 580050000879 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 580050000880 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 580050000881 Walker A/P-loop; other site 580050000882 ATP binding site [chemical binding]; other site 580050000883 Q-loop/lid; other site 580050000884 ABC transporter signature motif; other site 580050000885 Walker B; other site 580050000886 D-loop; other site 580050000887 H-loop/switch region; other site 580050000888 FtsX-like permease family; Region: FtsX; pfam02687 580050000889 Predicted permeases [General function prediction only]; Region: COG0679 580050000890 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 580050000891 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 580050000892 metal binding site [ion binding]; metal-binding site 580050000893 putative dimer interface [polypeptide binding]; other site 580050000894 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 580050000895 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 580050000896 homodimer interface [polypeptide binding]; other site 580050000897 oligonucleotide binding site [chemical binding]; other site 580050000898 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 580050000899 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 580050000900 GTPase CgtA; Reviewed; Region: obgE; PRK12296 580050000901 GTP1/OBG; Region: GTP1_OBG; pfam01018 580050000902 Obg GTPase; Region: Obg; cd01898 580050000903 G1 box; other site 580050000904 GTP/Mg2+ binding site [chemical binding]; other site 580050000905 Switch I region; other site 580050000906 G2 box; other site 580050000907 G3 box; other site 580050000908 Switch II region; other site 580050000909 G4 box; other site 580050000910 G5 box; other site 580050000911 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 580050000912 gamma-glutamyl kinase; Provisional; Region: PRK05429 580050000913 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 580050000914 nucleotide binding site [chemical binding]; other site 580050000915 homotetrameric interface [polypeptide binding]; other site 580050000916 putative phosphate binding site [ion binding]; other site 580050000917 putative allosteric binding site; other site 580050000918 PUA domain; Region: PUA; pfam01472 580050000919 aspartate aminotransferase; Provisional; Region: PRK05764 580050000920 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050000921 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050000922 homodimer interface [polypeptide binding]; other site 580050000923 catalytic residue [active] 580050000924 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 580050000925 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 580050000926 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 580050000927 putative homodimer interface [polypeptide binding]; other site 580050000928 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 580050000929 heterodimer interface [polypeptide binding]; other site 580050000930 homodimer interface [polypeptide binding]; other site 580050000931 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 580050000932 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 580050000933 23S rRNA interface [nucleotide binding]; other site 580050000934 L7/L12 interface [polypeptide binding]; other site 580050000935 putative thiostrepton binding site; other site 580050000936 L25 interface [polypeptide binding]; other site 580050000937 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 580050000938 mRNA/rRNA interface [nucleotide binding]; other site 580050000939 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 580050000940 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 580050000941 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 580050000942 BioY family; Region: BioY; pfam02632 580050000943 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 580050000944 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 580050000945 ATP-grasp domain; Region: ATP-grasp_4; cl17255 580050000946 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 580050000947 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 580050000948 carboxyltransferase (CT) interaction site; other site 580050000949 biotinylation site [posttranslational modification]; other site 580050000950 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 580050000951 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 580050000952 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 580050000953 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 580050000954 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 580050000955 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 580050000956 FMN binding site [chemical binding]; other site 580050000957 substrate binding site [chemical binding]; other site 580050000958 putative catalytic residue [active] 580050000959 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 580050000960 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 580050000961 active site 2 [active] 580050000962 active site 1 [active] 580050000963 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 580050000964 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 580050000965 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 580050000966 putative NAD(P) binding site [chemical binding]; other site 580050000967 active site 580050000968 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 580050000969 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 580050000970 active site 580050000971 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 580050000972 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 580050000973 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 580050000974 NAD binding site [chemical binding]; other site 580050000975 dimer interface [polypeptide binding]; other site 580050000976 tetramer (dimer of dimers) interface [polypeptide binding]; other site 580050000977 substrate binding site [chemical binding]; other site 580050000978 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 580050000979 16S/18S rRNA binding site [nucleotide binding]; other site 580050000980 S13e-L30e interaction site [polypeptide binding]; other site 580050000981 25S rRNA binding site [nucleotide binding]; other site 580050000982 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 580050000983 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 580050000984 oligomer interface [polypeptide binding]; other site 580050000985 RNA binding site [nucleotide binding]; other site 580050000986 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 580050000987 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 580050000988 RNase E interface [polypeptide binding]; other site 580050000989 trimer interface [polypeptide binding]; other site 580050000990 active site 580050000991 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 580050000992 putative nucleic acid binding region [nucleotide binding]; other site 580050000993 G-X-X-G motif; other site 580050000994 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 580050000995 RNA binding site [nucleotide binding]; other site 580050000996 domain interface; other site 580050000997 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 580050000998 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 580050000999 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 580050001000 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 580050001001 dimer interface [polypeptide binding]; other site 580050001002 putative radical transfer pathway; other site 580050001003 diiron center [ion binding]; other site 580050001004 tyrosyl radical; other site 580050001005 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 580050001006 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 580050001007 Class I ribonucleotide reductase; Region: RNR_I; cd01679 580050001008 active site 580050001009 dimer interface [polypeptide binding]; other site 580050001010 catalytic residues [active] 580050001011 effector binding site; other site 580050001012 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 580050001013 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 580050001014 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 580050001015 catalytic residues [active] 580050001016 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 580050001017 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 580050001018 active site 580050001019 catalytic tetrad [active] 580050001020 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 580050001021 Peptidase family U32; Region: Peptidase_U32; pfam01136 580050001022 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 580050001023 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 580050001024 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 580050001025 substrate binding site; other site 580050001026 dimer interface; other site 580050001027 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 580050001028 putative substrate binding pocket [chemical binding]; other site 580050001029 AC domain interface; other site 580050001030 catalytic triad [active] 580050001031 AB domain interface; other site 580050001032 interchain disulfide; other site 580050001033 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 580050001034 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 580050001035 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 580050001036 trimer interface [polypeptide binding]; other site 580050001037 active site 580050001038 G bulge; other site 580050001039 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 580050001040 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 580050001041 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 580050001042 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 580050001043 catalytic triad [active] 580050001044 catalytic triad [active] 580050001045 oxyanion hole [active] 580050001046 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 580050001047 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 580050001048 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 580050001049 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 580050001050 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 580050001051 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 580050001052 dimer interface [polypeptide binding]; other site 580050001053 phosphorylation site [posttranslational modification] 580050001054 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580050001055 ATP binding site [chemical binding]; other site 580050001056 Mg2+ binding site [ion binding]; other site 580050001057 G-X-G motif; other site 580050001058 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 580050001059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580050001060 active site 580050001061 phosphorylation site [posttranslational modification] 580050001062 intermolecular recognition site; other site 580050001063 dimerization interface [polypeptide binding]; other site 580050001064 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 580050001065 DNA binding site [nucleotide binding] 580050001066 PBP superfamily domain; Region: PBP_like_2; cl17296 580050001067 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 580050001068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050001069 dimer interface [polypeptide binding]; other site 580050001070 conserved gate region; other site 580050001071 putative PBP binding loops; other site 580050001072 ABC-ATPase subunit interface; other site 580050001073 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 580050001074 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050001075 dimer interface [polypeptide binding]; other site 580050001076 conserved gate region; other site 580050001077 putative PBP binding loops; other site 580050001078 ABC-ATPase subunit interface; other site 580050001079 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 580050001080 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 580050001081 Walker A/P-loop; other site 580050001082 ATP binding site [chemical binding]; other site 580050001083 Q-loop/lid; other site 580050001084 ABC transporter signature motif; other site 580050001085 Walker B; other site 580050001086 D-loop; other site 580050001087 H-loop/switch region; other site 580050001088 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 580050001089 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 580050001090 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 580050001091 intersubunit interface [polypeptide binding]; other site 580050001092 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 580050001093 23S rRNA interface [nucleotide binding]; other site 580050001094 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 580050001095 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 580050001096 peripheral dimer interface [polypeptide binding]; other site 580050001097 core dimer interface [polypeptide binding]; other site 580050001098 L10 interface [polypeptide binding]; other site 580050001099 L11 interface [polypeptide binding]; other site 580050001100 putative EF-Tu interaction site [polypeptide binding]; other site 580050001101 putative EF-G interaction site [polypeptide binding]; other site 580050001102 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 580050001103 phosphopeptide binding site; other site 580050001104 Part of AAA domain; Region: AAA_19; pfam13245 580050001105 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 580050001106 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 580050001107 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 580050001108 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 580050001109 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 580050001110 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 580050001111 Coenzyme A binding pocket [chemical binding]; other site 580050001112 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 580050001113 oligomerisation interface [polypeptide binding]; other site 580050001114 mobile loop; other site 580050001115 roof hairpin; other site 580050001116 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 580050001117 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 580050001118 FAD binding domain; Region: FAD_binding_4; pfam01565 580050001119 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 580050001120 amino acid transporter; Region: 2A0306; TIGR00909 580050001121 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 580050001122 Ferredoxin [Energy production and conversion]; Region: COG1146 580050001123 4Fe-4S binding domain; Region: Fer4; pfam00037 580050001124 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 580050001125 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050001126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050001127 homodimer interface [polypeptide binding]; other site 580050001128 catalytic residue [active] 580050001129 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 580050001130 active site 580050001131 DNA polymerase IV; Validated; Region: PRK02406 580050001132 DNA binding site [nucleotide binding] 580050001133 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 580050001134 dimerization interface [polypeptide binding]; other site 580050001135 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 580050001136 NAD binding site [chemical binding]; other site 580050001137 ligand binding site [chemical binding]; other site 580050001138 catalytic site [active] 580050001139 Uncharacterized conserved protein [Function unknown]; Region: COG1739 580050001140 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 580050001141 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 580050001142 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 580050001143 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 580050001144 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 580050001145 23S rRNA interface [nucleotide binding]; other site 580050001146 L3 interface [polypeptide binding]; other site 580050001147 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 580050001148 pullulanase, type I; Region: pulA_typeI; TIGR02104 580050001149 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 580050001150 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 580050001151 active site 580050001152 catalytic site [active] 580050001153 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 580050001154 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 580050001155 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 580050001156 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 580050001157 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 580050001158 putative catalytic cysteine [active] 580050001159 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 580050001160 putative active site [active] 580050001161 metal binding site [ion binding]; metal-binding site 580050001162 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 580050001163 YwiC-like protein; Region: YwiC; pfam14256 580050001164 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 580050001165 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 580050001166 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 580050001167 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 580050001168 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 580050001169 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 580050001170 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 580050001171 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 580050001172 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 580050001173 putative translocon binding site; other site 580050001174 protein-rRNA interface [nucleotide binding]; other site 580050001175 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 580050001176 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 580050001177 G-X-X-G motif; other site 580050001178 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 580050001179 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 580050001180 23S rRNA interface [nucleotide binding]; other site 580050001181 5S rRNA interface [nucleotide binding]; other site 580050001182 putative antibiotic binding site [chemical binding]; other site 580050001183 L25 interface [polypeptide binding]; other site 580050001184 L27 interface [polypeptide binding]; other site 580050001185 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 580050001186 23S rRNA interface [nucleotide binding]; other site 580050001187 putative translocon interaction site; other site 580050001188 signal recognition particle (SRP54) interaction site; other site 580050001189 L23 interface [polypeptide binding]; other site 580050001190 trigger factor interaction site; other site 580050001191 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 580050001192 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 580050001193 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 580050001194 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 580050001195 RNA binding site [nucleotide binding]; other site 580050001196 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 580050001197 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 580050001198 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 580050001199 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 580050001200 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 580050001201 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 580050001202 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 580050001203 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 580050001204 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 580050001205 23S rRNA interface [nucleotide binding]; other site 580050001206 L21e interface [polypeptide binding]; other site 580050001207 5S rRNA interface [nucleotide binding]; other site 580050001208 L27 interface [polypeptide binding]; other site 580050001209 L5 interface [polypeptide binding]; other site 580050001210 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 580050001211 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 580050001212 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 580050001213 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 580050001214 23S rRNA binding site [nucleotide binding]; other site 580050001215 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 580050001216 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 580050001217 SecY translocase; Region: SecY; pfam00344 580050001218 adenylate kinase; Reviewed; Region: adk; PRK00279 580050001219 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 580050001220 AMP-binding site [chemical binding]; other site 580050001221 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 580050001222 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 580050001223 rRNA binding site [nucleotide binding]; other site 580050001224 predicted 30S ribosome binding site; other site 580050001225 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 580050001226 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 580050001227 30S ribosomal protein S13; Region: bact_S13; TIGR03631 580050001228 30S ribosomal protein S11; Validated; Region: PRK05309 580050001229 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 580050001230 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 580050001231 alphaNTD homodimer interface [polypeptide binding]; other site 580050001232 alphaNTD - beta interaction site [polypeptide binding]; other site 580050001233 alphaNTD - beta' interaction site [polypeptide binding]; other site 580050001234 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 580050001235 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 580050001236 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 580050001237 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 580050001238 active site 580050001239 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 580050001240 NusA N-terminal domain; Region: NusA_N; pfam08529 580050001241 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 580050001242 RNA binding site [nucleotide binding]; other site 580050001243 homodimer interface [polypeptide binding]; other site 580050001244 NusA-like KH domain; Region: KH_5; pfam13184 580050001245 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 580050001246 G-X-X-G motif; other site 580050001247 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 580050001248 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 580050001249 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 580050001250 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 580050001251 G1 box; other site 580050001252 putative GEF interaction site [polypeptide binding]; other site 580050001253 GTP/Mg2+ binding site [chemical binding]; other site 580050001254 Switch I region; other site 580050001255 G2 box; other site 580050001256 G3 box; other site 580050001257 Switch II region; other site 580050001258 G4 box; other site 580050001259 G5 box; other site 580050001260 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 580050001261 Translation-initiation factor 2; Region: IF-2; pfam11987 580050001262 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 580050001263 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 580050001264 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 580050001265 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 580050001266 RNA binding site [nucleotide binding]; other site 580050001267 active site 580050001268 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 580050001269 FAD synthetase; Region: FAD_syn; pfam06574 580050001270 active site 580050001271 nucleotide binding site [chemical binding]; other site 580050001272 HIGH motif; other site 580050001273 KMSKS motif; other site 580050001274 Riboflavin kinase; Region: Flavokinase; smart00904 580050001275 DNA repair protein RadA; Provisional; Region: PRK11823 580050001276 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 580050001277 Walker A motif; other site 580050001278 ATP binding site [chemical binding]; other site 580050001279 Walker B motif; other site 580050001280 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 580050001281 ADP-ribosylation factor GTPase-activating protein AGD10; Provisional; Region: PLN03114 580050001282 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 580050001283 tetramer (dimer of dimers) interface [polypeptide binding]; other site 580050001284 active site 580050001285 dimer interface [polypeptide binding]; other site 580050001286 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 580050001287 RNA/DNA hybrid binding site [nucleotide binding]; other site 580050001288 active site 580050001289 potential RNA location 498892 ...498979 (tRNA-S and potential protein location 498852....499043 overlap by 88 bp) 580050001290 seryl-tRNA synthetase; Provisional; Region: PRK05431 580050001291 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 580050001292 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 580050001293 dimer interface [polypeptide binding]; other site 580050001294 active site 580050001295 motif 1; other site 580050001296 motif 2; other site 580050001297 motif 3; other site 580050001298 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 580050001299 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 580050001300 phosphoglucomutase; Validated; Region: PRK07564 580050001301 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 580050001302 active site 580050001303 substrate binding site [chemical binding]; other site 580050001304 metal binding site [ion binding]; metal-binding site 580050001305 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 580050001306 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 580050001307 Tetratricopeptide repeat; Region: TPR_12; pfam13424 580050001308 Tetratricopeptide repeat; Region: TPR_12; pfam13424 580050001309 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 580050001310 binding surface 580050001311 TPR motif; other site 580050001312 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 580050001313 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 580050001314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580050001315 active site 580050001316 phosphorylation site [posttranslational modification] 580050001317 intermolecular recognition site; other site 580050001318 dimerization interface [polypeptide binding]; other site 580050001319 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 580050001320 DNA binding residues [nucleotide binding] 580050001321 dimerization interface [polypeptide binding]; other site 580050001322 PspC domain; Region: PspC; pfam04024 580050001323 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 580050001324 PspC domain; Region: PspC; pfam04024 580050001325 IncA protein; Region: IncA; pfam04156 580050001326 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 580050001327 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 580050001328 homodimer interface [polypeptide binding]; other site 580050001329 substrate-cofactor binding pocket; other site 580050001330 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050001331 catalytic residue [active] 580050001332 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 580050001333 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 580050001334 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 580050001335 catalytic residue [active] 580050001336 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 580050001337 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 580050001338 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 580050001339 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 580050001340 dimer interface [polypeptide binding]; other site 580050001341 putative anticodon binding site; other site 580050001342 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 580050001343 motif 1; other site 580050001344 dimer interface [polypeptide binding]; other site 580050001345 active site 580050001346 motif 2; other site 580050001347 motif 3; other site 580050001348 Phospholipase B; Region: Phospholip_B; pfam04916 580050001349 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 580050001350 trimer interface [polypeptide binding]; other site 580050001351 active site 580050001352 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 580050001353 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 580050001354 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 580050001355 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 580050001356 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 580050001357 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 580050001358 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 580050001359 UbiA prenyltransferase family; Region: UbiA; pfam01040 580050001360 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050001361 catalytic core [active] 580050001362 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050001363 myosin-cross-reactive antigen; Provisional; Region: PRK13977 580050001364 potential frameshift: common BLAST hit:gi|184154213|ref|YP_001842554.1| oxidoreductase 580050001365 mannose-6-phosphate isomerase; Region: PLN02288 580050001366 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 580050001367 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 580050001368 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 580050001369 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580050001370 ATP binding site [chemical binding]; other site 580050001371 Mg2+ binding site [ion binding]; other site 580050001372 G-X-G motif; other site 580050001373 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 580050001374 PhoU domain; Region: PhoU; pfam01895 580050001375 PhoU domain; Region: PhoU; pfam01895 580050001376 phosphoserine aminotransferase; Provisional; Region: PRK03080 580050001377 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 580050001378 catalytic residue [active] 580050001379 CHAP domain; Region: CHAP; pfam05257 580050001380 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 580050001381 NlpC/P60 family; Region: NLPC_P60; cl17555 580050001382 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 580050001383 Ligand Binding Site [chemical binding]; other site 580050001384 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 580050001385 Ligand Binding Site [chemical binding]; other site 580050001386 OsmC-like protein; Region: OsmC; cl00767 580050001387 thymidylate synthase; Reviewed; Region: thyA; PRK01827 580050001388 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 580050001389 dimerization interface [polypeptide binding]; other site 580050001390 active site 580050001391 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 580050001392 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 580050001393 folate binding site [chemical binding]; other site 580050001394 NADP+ binding site [chemical binding]; other site 580050001395 Low molecular weight phosphatase family; Region: LMWPc; cd00115 580050001396 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 580050001397 active site 580050001398 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 580050001399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 580050001400 NAD(P) binding site [chemical binding]; other site 580050001401 active site 580050001402 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 580050001403 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 580050001404 putative active site [active] 580050001405 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 580050001406 serine/threonine protein kinase; Provisional; Region: PRK14879 580050001407 AAA domain; Region: AAA_21; pfam13304 580050001408 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 580050001409 putative active site [active] 580050001410 putative metal-binding site [ion binding]; other site 580050001411 Cutinase; Region: Cutinase; pfam01083 580050001412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 580050001413 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 580050001414 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 580050001415 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 580050001416 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 580050001417 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 580050001418 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 580050001419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 580050001420 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 580050001421 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 580050001422 Uncharacterized conserved protein [Function unknown]; Region: COG3189 580050001423 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 580050001424 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 580050001425 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 580050001426 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 580050001427 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 580050001428 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 580050001429 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 580050001430 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050001431 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050001432 DNA binding site [nucleotide binding] 580050001433 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 580050001434 putative dimerization interface [polypeptide binding]; other site 580050001435 putative ligand binding site [chemical binding]; other site 580050001436 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 580050001437 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050001438 motif II; other site 580050001439 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 580050001440 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 580050001441 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 580050001442 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 580050001443 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 580050001444 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 580050001445 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 580050001446 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 580050001447 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 580050001448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050001449 dimer interface [polypeptide binding]; other site 580050001450 conserved gate region; other site 580050001451 putative PBP binding loops; other site 580050001452 ABC-ATPase subunit interface; other site 580050001453 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050001454 dimer interface [polypeptide binding]; other site 580050001455 conserved gate region; other site 580050001456 putative PBP binding loops; other site 580050001457 ABC-ATPase subunit interface; other site 580050001458 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050001459 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050001460 DNA binding site [nucleotide binding] 580050001461 domain linker motif; other site 580050001462 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 580050001463 ligand binding site [chemical binding]; other site 580050001464 dimerization interface (open form) [polypeptide binding]; other site 580050001465 dimerization interface (closed form) [polypeptide binding]; other site 580050001466 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 580050001467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 580050001468 active site 580050001469 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 580050001470 Domain of unknown function DUF20; Region: UPF0118; pfam01594 580050001471 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 580050001472 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 580050001473 DXD motif; other site 580050001474 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 580050001475 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 580050001476 Walker A/P-loop; other site 580050001477 ATP binding site [chemical binding]; other site 580050001478 Q-loop/lid; other site 580050001479 ABC transporter signature motif; other site 580050001480 Walker B; other site 580050001481 D-loop; other site 580050001482 H-loop/switch region; other site 580050001483 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 580050001484 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 580050001485 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 580050001486 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 580050001487 Ligand Binding Site [chemical binding]; other site 580050001488 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 580050001489 active site 580050001490 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 580050001491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050001492 Walker A motif; other site 580050001493 ATP binding site [chemical binding]; other site 580050001494 Walker B motif; other site 580050001495 arginine finger; other site 580050001496 Peptidase family M41; Region: Peptidase_M41; pfam01434 580050001497 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 580050001498 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 580050001499 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 580050001500 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 580050001501 active site 580050001502 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 580050001503 catalytic triad [active] 580050001504 dimer interface [polypeptide binding]; other site 580050001505 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 580050001506 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580050001507 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580050001508 ABC transporter; Region: ABC_tran_2; pfam12848 580050001509 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580050001510 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 580050001511 active site 580050001512 catalytic residues [active] 580050001513 metal binding site [ion binding]; metal-binding site 580050001514 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 580050001515 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 580050001516 homodimer interface [polypeptide binding]; other site 580050001517 substrate-cofactor binding pocket; other site 580050001518 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050001519 catalytic residue [active] 580050001520 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 580050001521 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 580050001522 xylose isomerase; Provisional; Region: PRK05474 580050001523 xylose isomerase; Region: xylose_isom_A; TIGR02630 580050001524 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 580050001525 active site 580050001526 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050001527 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050001528 DNA binding site [nucleotide binding] 580050001529 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 580050001530 putative ligand binding site [chemical binding]; other site 580050001531 putative dimerization interface [polypeptide binding]; other site 580050001532 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 580050001533 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 580050001534 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 580050001535 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050001536 dimer interface [polypeptide binding]; other site 580050001537 conserved gate region; other site 580050001538 putative PBP binding loops; other site 580050001539 ABC-ATPase subunit interface; other site 580050001540 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 580050001541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050001542 dimer interface [polypeptide binding]; other site 580050001543 conserved gate region; other site 580050001544 putative PBP binding loops; other site 580050001545 ABC-ATPase subunit interface; other site 580050001546 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 580050001547 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 580050001548 inhibitor binding site; inhibition site 580050001549 active site 580050001550 Domain of unknown function (DUF303); Region: DUF303; pfam03629 580050001551 Domain of unknown function (DUF303); Region: DUF303; pfam03629 580050001552 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 580050001553 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 580050001554 substrate binding pocket [chemical binding]; other site 580050001555 catalytic triad [active] 580050001556 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 580050001557 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 580050001558 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 580050001559 active site 580050001560 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 580050001561 D-xylulose kinase; Region: XylB; TIGR01312 580050001562 nucleotide binding site [chemical binding]; other site 580050001563 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 580050001564 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 580050001565 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 580050001566 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 580050001567 peptide chain release factor 1; Validated; Region: prfA; PRK00591 580050001568 PCRF domain; Region: PCRF; pfam03462 580050001569 RF-1 domain; Region: RF-1; pfam00472 580050001570 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 580050001571 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 580050001572 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 580050001573 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 580050001574 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 580050001575 Mg++ binding site [ion binding]; other site 580050001576 putative catalytic motif [active] 580050001577 substrate binding site [chemical binding]; other site 580050001578 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 580050001579 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 580050001580 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 580050001581 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 580050001582 active site 580050001583 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 580050001584 catalytic site [active] 580050001585 putative active site [active] 580050001586 putative substrate binding site [chemical binding]; other site 580050001587 dimer interface [polypeptide binding]; other site 580050001588 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050001589 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 580050001590 active site 580050001591 motif I; other site 580050001592 motif II; other site 580050001593 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 580050001594 AAA domain; Region: AAA_30; pfam13604 580050001595 PIF1-like helicase; Region: PIF1; pfam05970 580050001596 Protein of unknown function (DUF805); Region: DUF805; cl01224 580050001597 prolyl-tRNA synthetase; Provisional; Region: PRK09194 580050001598 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 580050001599 dimer interface [polypeptide binding]; other site 580050001600 motif 1; other site 580050001601 active site 580050001602 motif 2; other site 580050001603 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 580050001604 putative deacylase active site [active] 580050001605 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 580050001606 active site 580050001607 motif 3; other site 580050001608 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 580050001609 anticodon binding site; other site 580050001610 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 580050001611 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 580050001612 dimer interface [polypeptide binding]; other site 580050001613 ssDNA binding site [nucleotide binding]; other site 580050001614 tetramer (dimer of dimers) interface [polypeptide binding]; other site 580050001615 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 580050001616 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 580050001617 active site 580050001618 Zn binding site [ion binding]; other site 580050001619 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 580050001620 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 580050001621 active site 580050001622 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 580050001623 Citrate synthase; Region: Citrate_synt; pfam00285 580050001624 oxalacetate binding site [chemical binding]; other site 580050001625 citrylCoA binding site [chemical binding]; other site 580050001626 coenzyme A binding site [chemical binding]; other site 580050001627 catalytic triad [active] 580050001628 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 580050001629 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 580050001630 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 580050001631 putative trimer interface [polypeptide binding]; other site 580050001632 putative CoA binding site [chemical binding]; other site 580050001633 peptide chain release factor 2; Validated; Region: prfB; PRK00578 580050001634 This domain is found in peptide chain release factors; Region: PCRF; smart00937 580050001635 RF-1 domain; Region: RF-1; pfam00472 580050001636 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 580050001637 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050001638 Walker A/P-loop; other site 580050001639 ATP binding site [chemical binding]; other site 580050001640 Q-loop/lid; other site 580050001641 ABC transporter signature motif; other site 580050001642 Walker B; other site 580050001643 D-loop; other site 580050001644 H-loop/switch region; other site 580050001645 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 580050001646 FtsX-like permease family; Region: FtsX; pfam02687 580050001647 Surface antigen [General function prediction only]; Region: COG3942 580050001648 CHAP domain; Region: CHAP; pfam05257 580050001649 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 580050001650 SmpB-tmRNA interface; other site 580050001651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 580050001652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 580050001653 substrate binding pocket [chemical binding]; other site 580050001654 membrane-bound complex binding site; other site 580050001655 hinge residues; other site 580050001656 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 580050001657 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 580050001658 substrate binding pocket [chemical binding]; other site 580050001659 membrane-bound complex binding site; other site 580050001660 hinge residues; other site 580050001661 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 580050001662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050001663 dimer interface [polypeptide binding]; other site 580050001664 conserved gate region; other site 580050001665 putative PBP binding loops; other site 580050001666 ABC-ATPase subunit interface; other site 580050001667 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 580050001668 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 580050001669 Walker A/P-loop; other site 580050001670 ATP binding site [chemical binding]; other site 580050001671 Q-loop/lid; other site 580050001672 ABC transporter signature motif; other site 580050001673 Walker B; other site 580050001674 D-loop; other site 580050001675 H-loop/switch region; other site 580050001676 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 580050001677 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 580050001678 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580050001679 active site 580050001680 phosphorylation site [posttranslational modification] 580050001681 intermolecular recognition site; other site 580050001682 dimerization interface [polypeptide binding]; other site 580050001683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 580050001684 DNA binding residues [nucleotide binding] 580050001685 dimerization interface [polypeptide binding]; other site 580050001686 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 580050001687 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 580050001688 glutaminase active site [active] 580050001689 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 580050001690 dimer interface [polypeptide binding]; other site 580050001691 active site 580050001692 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 580050001693 dimer interface [polypeptide binding]; other site 580050001694 active site 580050001695 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 580050001696 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 580050001697 active site 580050001698 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 580050001699 pantothenate kinase; Reviewed; Region: PRK13318 580050001700 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 580050001701 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 580050001702 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 580050001703 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050001704 dimer interface [polypeptide binding]; other site 580050001705 conserved gate region; other site 580050001706 putative PBP binding loops; other site 580050001707 ABC-ATPase subunit interface; other site 580050001708 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 580050001709 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050001710 dimer interface [polypeptide binding]; other site 580050001711 conserved gate region; other site 580050001712 putative PBP binding loops; other site 580050001713 ABC-ATPase subunit interface; other site 580050001714 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 580050001715 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580050001716 Walker A/P-loop; other site 580050001717 ATP binding site [chemical binding]; other site 580050001718 Q-loop/lid; other site 580050001719 ABC transporter signature motif; other site 580050001720 Walker B; other site 580050001721 D-loop; other site 580050001722 H-loop/switch region; other site 580050001723 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 580050001724 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580050001725 Walker A/P-loop; other site 580050001726 ATP binding site [chemical binding]; other site 580050001727 Q-loop/lid; other site 580050001728 ABC transporter signature motif; other site 580050001729 Walker B; other site 580050001730 D-loop; other site 580050001731 H-loop/switch region; other site 580050001732 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 580050001733 cystathionine gamma-synthase; Provisional; Region: PRK07811 580050001734 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 580050001735 homodimer interface [polypeptide binding]; other site 580050001736 substrate-cofactor binding pocket; other site 580050001737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050001738 catalytic residue [active] 580050001739 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 580050001740 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 580050001741 dimer interface [polypeptide binding]; other site 580050001742 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050001743 catalytic residue [active] 580050001744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 580050001745 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 580050001746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580050001747 ATP binding site [chemical binding]; other site 580050001748 ATP binding site [chemical binding]; other site 580050001749 putative Mg++ binding site [ion binding]; other site 580050001750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050001751 nucleotide binding region [chemical binding]; other site 580050001752 ATP-binding site [chemical binding]; other site 580050001753 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 580050001754 HRDC domain; Region: HRDC; pfam00570 580050001755 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 580050001756 putative active site [active] 580050001757 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 580050001758 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 580050001759 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 580050001760 active site 580050001761 8-oxo-dGMP binding site [chemical binding]; other site 580050001762 nudix motif; other site 580050001763 metal binding site [ion binding]; metal-binding site 580050001764 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 580050001765 PLD-like domain; Region: PLDc_2; pfam13091 580050001766 putative homodimer interface [polypeptide binding]; other site 580050001767 putative active site [active] 580050001768 catalytic site [active] 580050001769 DEAD-like helicases superfamily; Region: DEXDc; smart00487 580050001770 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580050001771 ATP binding site [chemical binding]; other site 580050001772 putative Mg++ binding site [ion binding]; other site 580050001773 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050001774 nucleotide binding region [chemical binding]; other site 580050001775 ATP-binding site [chemical binding]; other site 580050001776 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 580050001777 Fic family protein [Function unknown]; Region: COG3177 580050001778 Protein of unknown function DUF262; Region: DUF262; pfam03235 580050001779 Uncharacterized conserved protein [Function unknown]; Region: COG1479 580050001780 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 580050001781 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 580050001782 Fic/DOC family; Region: Fic; cl00960 580050001783 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 580050001784 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 580050001785 Coenzyme A binding pocket [chemical binding]; other site 580050001786 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 580050001787 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 580050001788 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 580050001789 putative active site [active] 580050001790 metal binding site [ion binding]; metal-binding site 580050001791 S-ribosylhomocysteinase; Provisional; Region: PRK02260 580050001792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 580050001793 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 580050001794 alanine racemase; Reviewed; Region: alr; PRK00053 580050001795 active site 580050001796 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 580050001797 dimer interface [polypeptide binding]; other site 580050001798 substrate binding site [chemical binding]; other site 580050001799 catalytic residues [active] 580050001800 DNA primase; Validated; Region: dnaG; PRK05667 580050001801 CHC2 zinc finger; Region: zf-CHC2; pfam01807 580050001802 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 580050001803 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 580050001804 active site 580050001805 metal binding site [ion binding]; metal-binding site 580050001806 interdomain interaction site; other site 580050001807 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 580050001808 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 580050001809 transmembrane helices; other site 580050001810 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 580050001811 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 580050001812 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 580050001813 TPP-binding site; other site 580050001814 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 580050001815 PYR/PP interface [polypeptide binding]; other site 580050001816 dimer interface [polypeptide binding]; other site 580050001817 TPP binding site [chemical binding]; other site 580050001818 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 580050001819 AIR carboxylase; Region: AIRC; pfam00731 580050001820 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 580050001821 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 580050001822 NAD binding site [chemical binding]; other site 580050001823 ATP-grasp domain; Region: ATP-grasp; pfam02222 580050001824 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 580050001825 metal binding site 2 [ion binding]; metal-binding site 580050001826 putative DNA binding helix; other site 580050001827 metal binding site 1 [ion binding]; metal-binding site 580050001828 dimer interface [polypeptide binding]; other site 580050001829 structural Zn2+ binding site [ion binding]; other site 580050001830 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 580050001831 Putative esterase; Region: Esterase; pfam00756 580050001832 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 580050001833 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 580050001834 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 580050001835 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 580050001836 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 580050001837 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 580050001838 dimerization interface [polypeptide binding]; other site 580050001839 putative ATP binding site [chemical binding]; other site 580050001840 amidophosphoribosyltransferase; Provisional; Region: PRK07272 580050001841 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 580050001842 active site 580050001843 tetramer interface [polypeptide binding]; other site 580050001844 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 580050001845 active site 580050001846 Y-family of DNA polymerases; Region: PolY; cl12025 580050001847 DNA polymerase IV; Reviewed; Region: PRK03103 580050001848 active site 580050001849 DNA binding site [nucleotide binding] 580050001850 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 580050001851 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 580050001852 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 580050001853 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 580050001854 Short C-terminal domain; Region: SHOCT; pfam09851 580050001855 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 580050001856 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 580050001857 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 580050001858 dimerization interface [polypeptide binding]; other site 580050001859 ATP binding site [chemical binding]; other site 580050001860 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 580050001861 dimerization interface [polypeptide binding]; other site 580050001862 ATP binding site [chemical binding]; other site 580050001863 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 580050001864 conserved cys residue [active] 580050001865 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 580050001866 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 580050001867 ATP binding site [chemical binding]; other site 580050001868 active site 580050001869 substrate binding site [chemical binding]; other site 580050001870 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 580050001871 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 580050001872 ATP-grasp domain; Region: ATP-grasp; pfam02222 580050001873 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 580050001874 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 580050001875 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 580050001876 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 580050001877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 580050001878 catalytic residue [active] 580050001879 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 580050001880 S17 interaction site [polypeptide binding]; other site 580050001881 S8 interaction site; other site 580050001882 16S rRNA interaction site [nucleotide binding]; other site 580050001883 streptomycin interaction site [chemical binding]; other site 580050001884 23S rRNA interaction site [nucleotide binding]; other site 580050001885 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 580050001886 30S ribosomal protein S7; Validated; Region: PRK05302 580050001887 elongation factor G; Reviewed; Region: PRK00007 580050001888 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 580050001889 G1 box; other site 580050001890 putative GEF interaction site [polypeptide binding]; other site 580050001891 GTP/Mg2+ binding site [chemical binding]; other site 580050001892 Switch I region; other site 580050001893 G2 box; other site 580050001894 G3 box; other site 580050001895 Switch II region; other site 580050001896 G4 box; other site 580050001897 G5 box; other site 580050001898 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 580050001899 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 580050001900 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 580050001901 elongation factor Tu; Reviewed; Region: PRK00049 580050001902 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 580050001903 G1 box; other site 580050001904 GEF interaction site [polypeptide binding]; other site 580050001905 GTP/Mg2+ binding site [chemical binding]; other site 580050001906 Switch I region; other site 580050001907 G2 box; other site 580050001908 G3 box; other site 580050001909 Switch II region; other site 580050001910 G4 box; other site 580050001911 G5 box; other site 580050001912 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 580050001913 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 580050001914 Antibiotic Binding Site [chemical binding]; other site 580050001915 Plant phosphoribosyltransferase C-terminal; Region: PRT_C; pfam08372 580050001916 elongation factor P; Validated; Region: PRK00529 580050001917 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 580050001918 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 580050001919 RNA binding site [nucleotide binding]; other site 580050001920 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 580050001921 RNA binding site [nucleotide binding]; other site 580050001922 transcription antitermination factor NusB; Region: nusB; TIGR01951 580050001923 putative RNA binding site [nucleotide binding]; other site 580050001924 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 580050001925 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 580050001926 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 580050001927 catalytic site [active] 580050001928 subunit interface [polypeptide binding]; other site 580050001929 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 580050001930 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 580050001931 ATP-grasp domain; Region: ATP-grasp_4; cl17255 580050001932 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 580050001933 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 580050001934 ATP-grasp domain; Region: ATP-grasp_4; cl17255 580050001935 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 580050001936 IMP binding site; other site 580050001937 dimer interface [polypeptide binding]; other site 580050001938 interdomain contacts; other site 580050001939 partial ornithine binding site; other site 580050001940 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 580050001941 active site 580050001942 dimer interface [polypeptide binding]; other site 580050001943 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 580050001944 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 580050001945 catalytic site [active] 580050001946 G-X2-G-X-G-K; other site 580050001947 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 580050001948 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 580050001949 S-adenosylmethionine synthetase; Validated; Region: PRK05250 580050001950 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 580050001951 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 580050001952 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 580050001953 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 580050001954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580050001955 S-adenosylmethionine binding site [chemical binding]; other site 580050001956 primosome assembly protein PriA; Provisional; Region: PRK14873 580050001957 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 580050001958 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 580050001959 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 580050001960 substrate binding site [chemical binding]; other site 580050001961 putative active site [active] 580050001962 putative cosubstrate binding site; other site 580050001963 catalytic site [active] 580050001964 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 580050001965 substrate binding site [chemical binding]; other site 580050001966 phosphoserine phosphatase SerB; Region: serB; TIGR00338 580050001967 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050001968 motif II; other site 580050001969 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 580050001970 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 580050001971 proteasome ATPase; Region: pup_AAA; TIGR03689 580050001972 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050001973 Walker A motif; other site 580050001974 ATP binding site [chemical binding]; other site 580050001975 Walker B motif; other site 580050001976 arginine finger; other site 580050001977 Pup-ligase protein; Region: Pup_ligase; cl15463 580050001978 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 580050001979 active site 580050001980 Pup-like protein; Region: Pup; cl05289 580050001981 Pup-ligase protein; Region: Pup_ligase; cl15463 580050001982 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 580050001983 IHF dimer interface [polypeptide binding]; other site 580050001984 IHF - DNA interface [nucleotide binding]; other site 580050001985 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 580050001986 adenylosuccinate lyase; Provisional; Region: PRK09285 580050001987 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 580050001988 tetramer interface [polypeptide binding]; other site 580050001989 active site 580050001990 Secretory lipase; Region: LIP; pfam03583 580050001991 von Willebrand factor type A domain; Region: VWA_2; pfam13519 580050001992 metal ion-dependent adhesion site (MIDAS); other site 580050001993 von Willebrand factor type A domain; Region: VWA_2; pfam13519 580050001994 metal ion-dependent adhesion site (MIDAS); other site 580050001995 Protein of unknown function DUF58; Region: DUF58; pfam01882 580050001996 MoxR-like ATPases [General function prediction only]; Region: COG0714 580050001997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 580050001998 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 580050001999 ligand binding site [chemical binding]; other site 580050002000 active site 580050002001 UGI interface [polypeptide binding]; other site 580050002002 catalytic site [active] 580050002003 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 580050002004 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 580050002005 DNA-binding site [nucleotide binding]; DNA binding site 580050002006 RNA-binding motif; other site 580050002007 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 580050002008 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 580050002009 ring oligomerisation interface [polypeptide binding]; other site 580050002010 ATP/Mg binding site [chemical binding]; other site 580050002011 stacking interactions; other site 580050002012 hinge regions; other site 580050002013 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 580050002014 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 580050002015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580050002016 active site 580050002017 phosphorylation site [posttranslational modification] 580050002018 intermolecular recognition site; other site 580050002019 dimerization interface [polypeptide binding]; other site 580050002020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 580050002021 DNA binding site [nucleotide binding] 580050002022 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 580050002023 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 580050002024 dimerization interface [polypeptide binding]; other site 580050002025 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 580050002026 dimer interface [polypeptide binding]; other site 580050002027 phosphorylation site [posttranslational modification] 580050002028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580050002029 ATP binding site [chemical binding]; other site 580050002030 Mg2+ binding site [ion binding]; other site 580050002031 G-X-G motif; other site 580050002032 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 580050002033 DNA-binding site [nucleotide binding]; DNA binding site 580050002034 RNA-binding motif; other site 580050002035 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 580050002036 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 580050002037 Ligand Binding Site [chemical binding]; other site 580050002038 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 580050002039 Ligand Binding Site [chemical binding]; other site 580050002040 Clp protease ATP binding subunit; Region: clpC; CHL00095 580050002041 Clp amino terminal domain; Region: Clp_N; pfam02861 580050002042 Clp amino terminal domain; Region: Clp_N; pfam02861 580050002043 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050002044 Walker A motif; other site 580050002045 ATP binding site [chemical binding]; other site 580050002046 Walker B motif; other site 580050002047 arginine finger; other site 580050002048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050002049 Walker A motif; other site 580050002050 ATP binding site [chemical binding]; other site 580050002051 Walker B motif; other site 580050002052 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 580050002053 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 580050002054 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 580050002055 dimer interface [polypeptide binding]; other site 580050002056 anticodon binding site; other site 580050002057 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 580050002058 motif 1; other site 580050002059 dimer interface [polypeptide binding]; other site 580050002060 active site 580050002061 motif 2; other site 580050002062 GAD domain; Region: GAD; pfam02938 580050002063 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 580050002064 active site 580050002065 motif 3; other site 580050002066 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 580050002067 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 580050002068 dimer interface [polypeptide binding]; other site 580050002069 motif 1; other site 580050002070 active site 580050002071 motif 2; other site 580050002072 motif 3; other site 580050002073 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 580050002074 anticodon binding site; other site 580050002075 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 580050002076 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 580050002077 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 580050002078 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 580050002079 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 580050002080 catalytic site [active] 580050002081 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 580050002082 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 580050002083 Walker A/P-loop; other site 580050002084 ATP binding site [chemical binding]; other site 580050002085 Q-loop/lid; other site 580050002086 ABC transporter signature motif; other site 580050002087 Walker B; other site 580050002088 D-loop; other site 580050002089 H-loop/switch region; other site 580050002090 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 580050002091 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 580050002092 substrate binding pocket [chemical binding]; other site 580050002093 membrane-bound complex binding site; other site 580050002094 hinge residues; other site 580050002095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050002096 dimer interface [polypeptide binding]; other site 580050002097 conserved gate region; other site 580050002098 ABC-ATPase subunit interface; other site 580050002099 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 580050002100 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050002101 dimer interface [polypeptide binding]; other site 580050002102 conserved gate region; other site 580050002103 putative PBP binding loops; other site 580050002104 ABC-ATPase subunit interface; other site 580050002105 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 580050002106 DEAD-like helicases superfamily; Region: DEXDc; smart00487 580050002107 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580050002108 ATP binding site [chemical binding]; other site 580050002109 putative Mg++ binding site [ion binding]; other site 580050002110 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050002111 nucleotide binding region [chemical binding]; other site 580050002112 ATP-binding site [chemical binding]; other site 580050002113 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 580050002114 recombination factor protein RarA; Reviewed; Region: PRK13342 580050002115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050002116 Walker A motif; other site 580050002117 ATP binding site [chemical binding]; other site 580050002118 Walker B motif; other site 580050002119 arginine finger; other site 580050002120 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 580050002121 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050002122 putative substrate translocation pore; other site 580050002123 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050002124 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 580050002125 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 580050002126 acyl-activating enzyme (AAE) consensus motif; other site 580050002127 putative AMP binding site [chemical binding]; other site 580050002128 putative active site [active] 580050002129 putative CoA binding site [chemical binding]; other site 580050002130 Transposase, Mutator family; Region: Transposase_mut; pfam00872 580050002131 MULE transposase domain; Region: MULE; pfam10551 580050002132 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 580050002133 Coenzyme A binding pocket [chemical binding]; other site 580050002134 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 580050002135 hypothetical protein; Provisional; Region: PRK11770 580050002136 Domain of unknown function (DUF307); Region: DUF307; pfam03733 580050002137 Domain of unknown function (DUF307); Region: DUF307; pfam03733 580050002138 Putative transcription activator [Transcription]; Region: TenA; COG0819 580050002139 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 580050002140 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 580050002141 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 580050002142 active site 580050002143 catalytic tetrad [active] 580050002144 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 580050002145 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 580050002146 Walker A/P-loop; other site 580050002147 ATP binding site [chemical binding]; other site 580050002148 Q-loop/lid; other site 580050002149 ABC transporter signature motif; other site 580050002150 Walker B; other site 580050002151 D-loop; other site 580050002152 H-loop/switch region; other site 580050002153 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 580050002154 Walker A/P-loop; other site 580050002155 ATP binding site [chemical binding]; other site 580050002156 Q-loop/lid; other site 580050002157 ABC transporter signature motif; other site 580050002158 Walker B; other site 580050002159 D-loop; other site 580050002160 H-loop/switch region; other site 580050002161 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 580050002162 Predicted membrane protein [Function unknown]; Region: COG3601 580050002163 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 580050002164 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 580050002165 nucleotide binding site [chemical binding]; other site 580050002166 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050002167 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050002168 homodimer interface [polypeptide binding]; other site 580050002169 catalytic residue [active] 580050002170 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 580050002171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050002172 Walker A/P-loop; other site 580050002173 ATP binding site [chemical binding]; other site 580050002174 Q-loop/lid; other site 580050002175 ABC transporter signature motif; other site 580050002176 Walker B; other site 580050002177 D-loop; other site 580050002178 H-loop/switch region; other site 580050002179 Ligase N family; Region: LIGANc; smart00532 580050002180 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 580050002181 nucleotide binding pocket [chemical binding]; other site 580050002182 K-X-D-G motif; other site 580050002183 catalytic site [active] 580050002184 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 580050002185 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 580050002186 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 580050002187 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 580050002188 Dimer interface [polypeptide binding]; other site 580050002189 Domain of unknown function DUF59; Region: DUF59; cl00941 580050002190 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 580050002191 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 580050002192 glutamine synthetase, type I; Region: GlnA; TIGR00653 580050002193 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 580050002194 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 580050002195 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 580050002196 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 580050002197 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 580050002198 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 580050002199 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 580050002200 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 580050002201 hypothetical protein; Provisional; Region: PRK07907 580050002202 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 580050002203 active site 580050002204 metal binding site [ion binding]; metal-binding site 580050002205 dimer interface [polypeptide binding]; other site 580050002206 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 580050002207 Histidine kinase; Region: HisKA_3; pfam07730 580050002208 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 580050002209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050002210 ABC transporter signature motif; other site 580050002211 Walker B; other site 580050002212 D-loop; other site 580050002213 H-loop/switch region; other site 580050002214 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 580050002215 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 580050002216 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 580050002217 Walker A/P-loop; other site 580050002218 ATP binding site [chemical binding]; other site 580050002219 Q-loop/lid; other site 580050002220 ABC transporter signature motif; other site 580050002221 Walker B; other site 580050002222 D-loop; other site 580050002223 H-loop/switch region; other site 580050002224 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 580050002225 Walker A/P-loop; other site 580050002226 ATP binding site [chemical binding]; other site 580050002227 Q-loop/lid; other site 580050002228 ABC transporter signature motif; other site 580050002229 Walker B; other site 580050002230 D-loop; other site 580050002231 H-loop/switch region; other site 580050002232 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 580050002233 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 580050002234 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 580050002235 Walker A/P-loop; other site 580050002236 ATP binding site [chemical binding]; other site 580050002237 Q-loop/lid; other site 580050002238 ABC transporter signature motif; other site 580050002239 Walker B; other site 580050002240 D-loop; other site 580050002241 H-loop/switch region; other site 580050002242 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 580050002243 FtsX-like permease family; Region: FtsX; pfam02687 580050002244 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 580050002245 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 580050002246 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 580050002247 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 580050002248 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 580050002249 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 580050002250 dimer interface [polypeptide binding]; other site 580050002251 motif 1; other site 580050002252 active site 580050002253 motif 2; other site 580050002254 motif 3; other site 580050002255 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 580050002256 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 580050002257 putative tRNA-binding site [nucleotide binding]; other site 580050002258 B3/4 domain; Region: B3_4; pfam03483 580050002259 tRNA synthetase B5 domain; Region: B5; smart00874 580050002260 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 580050002261 dimer interface [polypeptide binding]; other site 580050002262 motif 1; other site 580050002263 motif 3; other site 580050002264 motif 2; other site 580050002265 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 580050002266 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 580050002267 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 580050002268 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 580050002269 heterotetramer interface [polypeptide binding]; other site 580050002270 active site pocket [active] 580050002271 cleavage site 580050002272 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 580050002273 feedback inhibition sensing region; other site 580050002274 homohexameric interface [polypeptide binding]; other site 580050002275 nucleotide binding site [chemical binding]; other site 580050002276 N-acetyl-L-glutamate binding site [chemical binding]; other site 580050002277 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 580050002278 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 580050002279 inhibitor-cofactor binding pocket; inhibition site 580050002280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050002281 catalytic residue [active] 580050002282 ornithine carbamoyltransferase; Provisional; Region: PRK00779 580050002283 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 580050002284 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 580050002285 arginine repressor; Provisional; Region: PRK03341 580050002286 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 580050002287 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 580050002288 argininosuccinate synthase; Provisional; Region: PRK13820 580050002289 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 580050002290 ANP binding site [chemical binding]; other site 580050002291 Substrate Binding Site II [chemical binding]; other site 580050002292 Substrate Binding Site I [chemical binding]; other site 580050002293 argininosuccinate lyase; Provisional; Region: PRK00855 580050002294 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 580050002295 active sites [active] 580050002296 tetramer interface [polypeptide binding]; other site 580050002297 acetoin reductases; Region: 23BDH; TIGR02415 580050002298 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 580050002299 NAD(P) binding site [chemical binding]; other site 580050002300 active site 580050002301 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 580050002302 Zn2+ binding site [ion binding]; other site 580050002303 Mg2+ binding site [ion binding]; other site 580050002304 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 580050002305 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 580050002306 active site 580050002307 HIGH motif; other site 580050002308 dimer interface [polypeptide binding]; other site 580050002309 KMSKS motif; other site 580050002310 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 580050002311 RNA binding surface [nucleotide binding]; other site 580050002312 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 580050002313 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050002314 active site 580050002315 motif I; other site 580050002316 motif II; other site 580050002317 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050002318 motif II; other site 580050002319 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 580050002320 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 580050002321 RNA binding surface [nucleotide binding]; other site 580050002322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580050002323 S-adenosylmethionine binding site [chemical binding]; other site 580050002324 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 580050002325 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 580050002326 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 580050002327 TrkA-N domain; Region: TrkA_N; pfam02254 580050002328 TrkA-C domain; Region: TrkA_C; pfam02080 580050002329 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 580050002330 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 580050002331 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 580050002332 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 580050002333 Walker A/P-loop; other site 580050002334 ATP binding site [chemical binding]; other site 580050002335 Q-loop/lid; other site 580050002336 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 580050002337 ABC transporter signature motif; other site 580050002338 Walker B; other site 580050002339 D-loop; other site 580050002340 H-loop/switch region; other site 580050002341 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 580050002342 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 580050002343 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050002344 motif II; other site 580050002345 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 580050002346 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 580050002347 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050002348 catalytic residue [active] 580050002349 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 580050002350 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 580050002351 putative catalytic cysteine [active] 580050002352 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 580050002353 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 580050002354 active site 580050002355 (T/H)XGH motif; other site 580050002356 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 580050002357 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 580050002358 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 580050002359 active site 580050002360 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 580050002361 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 580050002362 Substrate binding site; other site 580050002363 Mg++ binding site; other site 580050002364 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 580050002365 active site 580050002366 substrate binding site [chemical binding]; other site 580050002367 CoA binding site [chemical binding]; other site 580050002368 Oligomerisation domain; Region: Oligomerisation; pfam02410 580050002369 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050002370 catalytic core [active] 580050002371 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 580050002372 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050002373 catalytic core [active] 580050002374 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 580050002375 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 580050002376 Cl binding site [ion binding]; other site 580050002377 oligomer interface [polypeptide binding]; other site 580050002378 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 580050002379 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 580050002380 substrate binding pocket [chemical binding]; other site 580050002381 membrane-bound complex binding site; other site 580050002382 hinge residues; other site 580050002383 aminoacyl-tRNA ligase; Region: PLN02563 580050002384 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 580050002385 active site 580050002386 HIGH motif; other site 580050002387 nucleotide binding site [chemical binding]; other site 580050002388 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 580050002389 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 580050002390 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 580050002391 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 580050002392 active site 580050002393 KMSKS motif; other site 580050002394 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 580050002395 tRNA binding surface [nucleotide binding]; other site 580050002396 Helix-hairpin-helix motif; Region: HHH; pfam00633 580050002397 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 580050002398 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 580050002399 Competence protein; Region: Competence; pfam03772 580050002400 hypothetical protein; Reviewed; Region: PRK07914 580050002401 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 580050002402 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 580050002403 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 580050002404 Glycoprotease family; Region: Peptidase_M22; pfam00814 580050002405 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 580050002406 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 580050002407 Coenzyme A binding pocket [chemical binding]; other site 580050002408 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 580050002409 UGMP family protein; Validated; Region: PRK09604 580050002410 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 580050002411 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 580050002412 isocitrate dehydrogenase; Validated; Region: PRK08299 580050002413 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 580050002414 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 580050002415 phosphate binding site [ion binding]; other site 580050002416 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 580050002417 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 580050002418 acyl-activating enzyme (AAE) consensus motif; other site 580050002419 putative AMP binding site [chemical binding]; other site 580050002420 putative active site [active] 580050002421 putative CoA binding site [chemical binding]; other site 580050002422 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 580050002423 active site 580050002424 catalytic residues [active] 580050002425 metal binding site [ion binding]; metal-binding site 580050002426 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 580050002427 rRNA interaction site [nucleotide binding]; other site 580050002428 S8 interaction site; other site 580050002429 putative laminin-1 binding site; other site 580050002430 elongation factor Ts; Provisional; Region: tsf; PRK09377 580050002431 UBA/TS-N domain; Region: UBA; pfam00627 580050002432 Elongation factor TS; Region: EF_TS; pfam00889 580050002433 Elongation factor TS; Region: EF_TS; pfam00889 580050002434 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 580050002435 putative nucleotide binding site [chemical binding]; other site 580050002436 uridine monophosphate binding site [chemical binding]; other site 580050002437 homohexameric interface [polypeptide binding]; other site 580050002438 ribosome recycling factor; Reviewed; Region: frr; PRK00083 580050002439 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 580050002440 hinge region; other site 580050002441 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 580050002442 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 580050002443 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 580050002444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 580050002445 FeS/SAM binding site; other site 580050002446 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 580050002447 WHG domain; Region: WHG; pfam13305 580050002448 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 580050002449 Walker A/P-loop; other site 580050002450 ATP binding site [chemical binding]; other site 580050002451 ABC transporter; Region: ABC_tran; pfam00005 580050002452 Q-loop/lid; other site 580050002453 ABC transporter signature motif; other site 580050002454 Walker B; other site 580050002455 D-loop; other site 580050002456 H-loop/switch region; other site 580050002457 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 580050002458 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 580050002459 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 580050002460 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 580050002461 substrate binding site [chemical binding]; other site 580050002462 glutamase interaction surface [polypeptide binding]; other site 580050002463 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 580050002464 anthranilate synthase component I; Provisional; Region: PRK13571 580050002465 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 580050002466 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 580050002467 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 580050002468 putative uracil binding site [chemical binding]; other site 580050002469 putative active site [active] 580050002470 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 580050002471 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 580050002472 active site 580050002473 ribulose/triose binding site [chemical binding]; other site 580050002474 phosphate binding site [ion binding]; other site 580050002475 substrate (anthranilate) binding pocket [chemical binding]; other site 580050002476 product (indole) binding pocket [chemical binding]; other site 580050002477 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 580050002478 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050002479 catalytic residue [active] 580050002480 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 580050002481 substrate binding site [chemical binding]; other site 580050002482 active site 580050002483 catalytic residues [active] 580050002484 heterodimer interface [polypeptide binding]; other site 580050002485 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 580050002486 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 580050002487 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 580050002488 substrate binding site [chemical binding]; other site 580050002489 hexamer interface [polypeptide binding]; other site 580050002490 metal binding site [ion binding]; metal-binding site 580050002491 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 580050002492 homodimer interface [polypeptide binding]; other site 580050002493 putative metal binding site [ion binding]; other site 580050002494 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 580050002495 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 580050002496 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 580050002497 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 580050002498 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 580050002499 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 580050002500 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 580050002501 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 580050002502 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 580050002503 phosphopeptide binding site; other site 580050002504 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 580050002505 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 580050002506 DNA binding residues [nucleotide binding] 580050002507 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 580050002508 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 580050002509 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 580050002510 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050002511 motif II; other site 580050002512 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 580050002513 DEAD-like helicases superfamily; Region: DEXDc; smart00487 580050002514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580050002515 ATP binding site [chemical binding]; other site 580050002516 putative Mg++ binding site [ion binding]; other site 580050002517 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050002518 nucleotide binding region [chemical binding]; other site 580050002519 ATP-binding site [chemical binding]; other site 580050002520 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 580050002521 Predicted transcriptional regulator [Transcription]; Region: COG2378 580050002522 WYL domain; Region: WYL; pfam13280 580050002523 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580050002524 active site 580050002525 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 580050002526 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 580050002527 active site 580050002528 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 580050002529 CMP-binding site; other site 580050002530 The sites determining sugar specificity; other site 580050002531 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 580050002532 G1 box; other site 580050002533 GTP/Mg2+ binding site [chemical binding]; other site 580050002534 Switch I region; other site 580050002535 G2 box; other site 580050002536 Switch II region; other site 580050002537 G3 box; other site 580050002538 G4 box; other site 580050002539 G5 box; other site 580050002540 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 580050002541 G1 box; other site 580050002542 GTP/Mg2+ binding site [chemical binding]; other site 580050002543 Switch I region; other site 580050002544 G2 box; other site 580050002545 G3 box; other site 580050002546 Switch II region; other site 580050002547 G4 box; other site 580050002548 G5 box; other site 580050002549 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 580050002550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 580050002551 RNA binding surface [nucleotide binding]; other site 580050002552 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 580050002553 active site 580050002554 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 580050002555 amphipathic channel; other site 580050002556 Asn-Pro-Ala signature motifs; other site 580050002557 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 580050002558 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 580050002559 purine monophosphate binding site [chemical binding]; other site 580050002560 dimer interface [polypeptide binding]; other site 580050002561 putative catalytic residues [active] 580050002562 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 580050002563 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 580050002564 CoA binding domain; Region: CoA_binding; pfam02629 580050002565 CoA-ligase; Region: Ligase_CoA; pfam00549 580050002566 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 580050002567 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 580050002568 CoA-ligase; Region: Ligase_CoA; pfam00549 580050002569 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 580050002570 active site 580050002571 Preprotein translocase subunit; Region: YajC; pfam02699 580050002572 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 580050002573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050002574 Walker A motif; other site 580050002575 ATP binding site [chemical binding]; other site 580050002576 Walker B motif; other site 580050002577 arginine finger; other site 580050002578 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 580050002579 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 580050002580 RuvA N terminal domain; Region: RuvA_N; pfam01330 580050002581 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 580050002582 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 580050002583 active site 580050002584 putative DNA-binding cleft [nucleotide binding]; other site 580050002585 dimer interface [polypeptide binding]; other site 580050002586 hypothetical protein; Validated; Region: PRK00110 580050002587 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 580050002588 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 580050002589 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK07920 580050002590 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 580050002591 putative acyl-acceptor binding pocket; other site 580050002592 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 580050002593 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 580050002594 thiS-thiF/thiG interaction site; other site 580050002595 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 580050002596 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 580050002597 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 580050002598 active site 580050002599 dimer interface [polypeptide binding]; other site 580050002600 motif 1; other site 580050002601 motif 2; other site 580050002602 motif 3; other site 580050002603 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 580050002604 anticodon binding site; other site 580050002605 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580050002606 ABC transporter; Region: ABC_tran; pfam00005 580050002607 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 580050002608 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 580050002609 Coenzyme A binding pocket [chemical binding]; other site 580050002610 PAC2 family; Region: PAC2; pfam09754 580050002611 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 580050002612 Fructosamine kinase; Region: Fructosamin_kin; cl17579 580050002613 chaperone protein DnaJ; Provisional; Region: PRK14278 580050002614 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 580050002615 HSP70 interaction site [polypeptide binding]; other site 580050002616 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 580050002617 Zn binding sites [ion binding]; other site 580050002618 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 580050002619 dimer interface [polypeptide binding]; other site 580050002620 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 580050002621 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 580050002622 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 580050002623 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 580050002624 TPP-binding site [chemical binding]; other site 580050002625 dimer interface [polypeptide binding]; other site 580050002626 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 580050002627 PYR/PP interface [polypeptide binding]; other site 580050002628 dimer interface [polypeptide binding]; other site 580050002629 TPP binding site [chemical binding]; other site 580050002630 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 580050002631 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 580050002632 putative active site [active] 580050002633 transaldolase; Provisional; Region: PRK03903 580050002634 catalytic residue [active] 580050002635 hypothetical protein; Validated; Region: PRK07682 580050002636 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050002637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050002638 homodimer interface [polypeptide binding]; other site 580050002639 catalytic residue [active] 580050002640 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 580050002641 AsnC family; Region: AsnC_trans_reg; pfam01037 580050002642 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 580050002643 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 580050002644 non-specific DNA binding site [nucleotide binding]; other site 580050002645 salt bridge; other site 580050002646 sequence-specific DNA binding site [nucleotide binding]; other site 580050002647 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050002648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050002649 homodimer interface [polypeptide binding]; other site 580050002650 catalytic residue [active] 580050002651 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 580050002652 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050002653 active site 580050002654 motif I; other site 580050002655 motif II; other site 580050002656 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050002657 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 580050002658 triosephosphate isomerase; Provisional; Region: PRK14567 580050002659 substrate binding site [chemical binding]; other site 580050002660 dimer interface [polypeptide binding]; other site 580050002661 catalytic triad [active] 580050002662 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 580050002663 Phosphoglycerate kinase; Region: PGK; pfam00162 580050002664 substrate binding site [chemical binding]; other site 580050002665 hinge regions; other site 580050002666 ADP binding site [chemical binding]; other site 580050002667 catalytic site [active] 580050002668 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 580050002669 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 580050002670 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 580050002671 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 580050002672 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 580050002673 shikimate binding site; other site 580050002674 NAD(P) binding site [chemical binding]; other site 580050002675 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 580050002676 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 580050002677 GIY-YIG motif/motif A; other site 580050002678 active site 580050002679 catalytic site [active] 580050002680 putative DNA binding site [nucleotide binding]; other site 580050002681 metal binding site [ion binding]; metal-binding site 580050002682 UvrB/uvrC motif; Region: UVR; pfam02151 580050002683 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 580050002684 Helix-hairpin-helix motif; Region: HHH; pfam00633 580050002685 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 580050002686 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 580050002687 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 580050002688 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 580050002689 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 580050002690 putative active site [active] 580050002691 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 580050002692 Predicted esterase [General function prediction only]; Region: COG0400 580050002693 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 580050002694 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050002695 Walker A/P-loop; other site 580050002696 ATP binding site [chemical binding]; other site 580050002697 Q-loop/lid; other site 580050002698 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580050002699 ABC transporter signature motif; other site 580050002700 Walker B; other site 580050002701 D-loop; other site 580050002702 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 580050002703 Cation efflux family; Region: Cation_efflux; pfam01545 580050002704 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 580050002705 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 580050002706 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 580050002707 active site 580050002708 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 580050002709 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 580050002710 putative substrate binding site [chemical binding]; other site 580050002711 putative ATP binding site [chemical binding]; other site 580050002712 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 580050002713 dimer interface [polypeptide binding]; other site 580050002714 peroxiredoxin; Region: AhpC; TIGR03137 580050002715 decamer (pentamer of dimers) interface [polypeptide binding]; other site 580050002716 catalytic triad [active] 580050002717 peroxidatic and resolving cysteines [active] 580050002718 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 580050002719 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 580050002720 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 580050002721 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 580050002722 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 580050002723 Transcriptional regulator [Transcription]; Region: LysR; COG0583 580050002724 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 580050002725 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 580050002726 dimerization interface [polypeptide binding]; other site 580050002727 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 580050002728 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050002729 motif II; other site 580050002730 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 580050002731 putative active site [active] 580050002732 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 580050002733 Predicted transcriptional regulators [Transcription]; Region: COG1733 580050002734 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 580050002735 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 580050002736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 580050002737 Coenzyme A binding pocket [chemical binding]; other site 580050002738 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 580050002739 active site 580050002740 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 580050002741 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 580050002742 heterodimer interface [polypeptide binding]; other site 580050002743 active site 580050002744 FMN binding site [chemical binding]; other site 580050002745 homodimer interface [polypeptide binding]; other site 580050002746 substrate binding site [chemical binding]; other site 580050002747 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 580050002748 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 580050002749 FAD binding pocket [chemical binding]; other site 580050002750 FAD binding motif [chemical binding]; other site 580050002751 phosphate binding motif [ion binding]; other site 580050002752 beta-alpha-beta structure motif; other site 580050002753 NAD binding pocket [chemical binding]; other site 580050002754 Iron coordination center [ion binding]; other site 580050002755 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 580050002756 active site 580050002757 dimer interface [polypeptide binding]; other site 580050002758 dihydroorotase; Validated; Region: pyrC; PRK09357 580050002759 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 580050002760 active site 580050002761 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 580050002762 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 580050002763 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 580050002764 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 580050002765 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 580050002766 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 580050002767 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 580050002768 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 580050002769 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 580050002770 metal binding triad; other site 580050002771 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 580050002772 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 580050002773 metal binding triad; other site 580050002774 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 580050002775 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 580050002776 FAD binding site [chemical binding]; other site 580050002777 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 580050002778 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 580050002779 THF binding site; other site 580050002780 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 580050002781 substrate binding site [chemical binding]; other site 580050002782 THF binding site; other site 580050002783 zinc-binding site [ion binding]; other site 580050002784 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050002785 catalytic core [active] 580050002786 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 580050002787 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580050002788 S-adenosylmethionine binding site [chemical binding]; other site 580050002789 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 580050002790 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050002791 Walker A/P-loop; other site 580050002792 ATP binding site [chemical binding]; other site 580050002793 Q-loop/lid; other site 580050002794 ABC transporter signature motif; other site 580050002795 Walker B; other site 580050002796 D-loop; other site 580050002797 H-loop/switch region; other site 580050002798 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 580050002799 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 580050002800 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 580050002801 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 580050002802 catalytic triad [active] 580050002803 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 580050002804 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 580050002805 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 580050002806 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 580050002807 active site 580050002808 dimer interface [polypeptide binding]; other site 580050002809 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 580050002810 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 580050002811 active site 580050002812 FMN binding site [chemical binding]; other site 580050002813 substrate binding site [chemical binding]; other site 580050002814 3Fe-4S cluster binding site [ion binding]; other site 580050002815 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 580050002816 domain interface; other site 580050002817 coproporphyrinogen III oxidase; Validated; Region: PRK05628 580050002818 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 580050002819 FeS/SAM binding site; other site 580050002820 HemN C-terminal domain; Region: HemN_C; pfam06969 580050002821 GTP-binding protein LepA; Provisional; Region: PRK05433 580050002822 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 580050002823 G1 box; other site 580050002824 putative GEF interaction site [polypeptide binding]; other site 580050002825 GTP/Mg2+ binding site [chemical binding]; other site 580050002826 Switch I region; other site 580050002827 G2 box; other site 580050002828 G3 box; other site 580050002829 Switch II region; other site 580050002830 G4 box; other site 580050002831 G5 box; other site 580050002832 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 580050002833 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 580050002834 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 580050002835 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 580050002836 UPF0126 domain; Region: UPF0126; pfam03458 580050002837 Predicted membrane protein [Function unknown]; Region: COG2860 580050002838 UPF0126 domain; Region: UPF0126; pfam03458 580050002839 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 580050002840 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 580050002841 homodimer interface [polypeptide binding]; other site 580050002842 substrate-cofactor binding pocket; other site 580050002843 catalytic residue [active] 580050002844 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 580050002845 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 580050002846 5S rRNA interface [nucleotide binding]; other site 580050002847 CTC domain interface [polypeptide binding]; other site 580050002848 L16 interface [polypeptide binding]; other site 580050002849 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 580050002850 Serine hydrolase (FSH1); Region: FSH1; pfam03959 580050002851 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 580050002852 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 580050002853 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 580050002854 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 580050002855 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 580050002856 ligand binding site [chemical binding]; other site 580050002857 homodimer interface [polypeptide binding]; other site 580050002858 NAD(P) binding site [chemical binding]; other site 580050002859 trimer interface B [polypeptide binding]; other site 580050002860 trimer interface A [polypeptide binding]; other site 580050002861 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 580050002862 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 580050002863 acyl-activating enzyme (AAE) consensus motif; other site 580050002864 putative AMP binding site [chemical binding]; other site 580050002865 putative active site [active] 580050002866 putative CoA binding site [chemical binding]; other site 580050002867 GTPase Era; Reviewed; Region: era; PRK00089 580050002868 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 580050002869 G1 box; other site 580050002870 GTP/Mg2+ binding site [chemical binding]; other site 580050002871 Switch I region; other site 580050002872 G2 box; other site 580050002873 Switch II region; other site 580050002874 G3 box; other site 580050002875 G4 box; other site 580050002876 G5 box; other site 580050002877 KH domain; Region: KH_2; pfam07650 580050002878 Domain of unknown function DUF21; Region: DUF21; pfam01595 580050002879 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 580050002880 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 580050002881 Transporter associated domain; Region: CorC_HlyC; smart01091 580050002882 metal-binding heat shock protein; Provisional; Region: PRK00016 580050002883 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 580050002884 PhoH-like protein; Region: PhoH; pfam02562 580050002885 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 580050002886 nucleotide binding site/active site [active] 580050002887 HIT family signature motif; other site 580050002888 catalytic residue [active] 580050002889 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 580050002890 RNA methyltransferase, RsmE family; Region: TIGR00046 580050002891 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 580050002892 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 580050002893 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 580050002894 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 580050002895 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 580050002896 ligand binding site; other site 580050002897 oligomer interface; other site 580050002898 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 580050002899 dimer interface [polypeptide binding]; other site 580050002900 N-terminal domain interface [polypeptide binding]; other site 580050002901 sulfate 1 binding site; other site 580050002902 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 580050002903 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 580050002904 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 580050002905 trimerization site [polypeptide binding]; other site 580050002906 active site 580050002907 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 580050002908 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 580050002909 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 580050002910 catalytic residue [active] 580050002911 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 580050002912 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 580050002913 Walker A/P-loop; other site 580050002914 ATP binding site [chemical binding]; other site 580050002915 Q-loop/lid; other site 580050002916 ABC transporter signature motif; other site 580050002917 Walker B; other site 580050002918 D-loop; other site 580050002919 H-loop/switch region; other site 580050002920 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 580050002921 FeS assembly protein SufD; Region: sufD; TIGR01981 580050002922 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 580050002923 FeS assembly protein SufB; Region: sufB; TIGR01980 580050002924 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 580050002925 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 580050002926 CTP synthetase; Validated; Region: pyrG; PRK05380 580050002927 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 580050002928 active site 580050002929 UTP binding site [chemical binding]; other site 580050002930 Catalytic site [active] 580050002931 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 580050002932 active site 580050002933 putative oxyanion hole; other site 580050002934 catalytic triad [active] 580050002935 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 580050002936 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 580050002937 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 580050002938 potential frameshift: common BLAST hit:gi|119025726|ref|YP_909571.1| pullulanase 580050002939 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 580050002940 catalytic nucleophile [active] 580050002941 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 580050002942 GIY-YIG motif/motif A; other site 580050002943 putative active site [active] 580050002944 putative metal binding site [ion binding]; other site 580050002945 Dehydroquinase class II; Region: DHquinase_II; pfam01220 580050002946 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 580050002947 trimer interface [polypeptide binding]; other site 580050002948 active site 580050002949 dimer interface [polypeptide binding]; other site 580050002950 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 580050002951 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 580050002952 ADP binding site [chemical binding]; other site 580050002953 magnesium binding site [ion binding]; other site 580050002954 putative shikimate binding site; other site 580050002955 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 580050002956 active site 580050002957 dimer interface [polypeptide binding]; other site 580050002958 metal binding site [ion binding]; metal-binding site 580050002959 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 580050002960 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 580050002961 Tetramer interface [polypeptide binding]; other site 580050002962 active site 580050002963 FMN-binding site [chemical binding]; other site 580050002964 YceG-like family; Region: YceG; pfam02618 580050002965 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 580050002966 dimerization interface [polypeptide binding]; other site 580050002967 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 580050002968 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 580050002969 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 580050002970 motif 1; other site 580050002971 active site 580050002972 motif 2; other site 580050002973 motif 3; other site 580050002974 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 580050002975 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050002976 catalytic core [active] 580050002977 Membrane protein of unknown function; Region: DUF360; pfam04020 580050002978 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 580050002979 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 580050002980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 580050002981 RNA binding surface [nucleotide binding]; other site 580050002982 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 580050002983 Part of AAA domain; Region: AAA_19; pfam13245 580050002984 Family description; Region: UvrD_C_2; pfam13538 580050002985 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 580050002986 active site 580050002987 xanthine permease; Region: pbuX; TIGR03173 580050002988 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 580050002989 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 580050002990 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050002991 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050002992 homodimer interface [polypeptide binding]; other site 580050002993 catalytic residue [active] 580050002994 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 580050002995 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 580050002996 active site 580050002997 Na/Ca binding site [ion binding]; other site 580050002998 catalytic site [active] 580050002999 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 580050003000 Peptidase C26; Region: Peptidase_C26; pfam07722 580050003001 catalytic triad [active] 580050003002 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 580050003003 putative deacylase active site [active] 580050003004 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 580050003005 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 580050003006 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 580050003007 Walker A/P-loop; other site 580050003008 ATP binding site [chemical binding]; other site 580050003009 Q-loop/lid; other site 580050003010 ABC transporter signature motif; other site 580050003011 Walker B; other site 580050003012 D-loop; other site 580050003013 H-loop/switch region; other site 580050003014 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 580050003015 DNA-binding site [nucleotide binding]; DNA binding site 580050003016 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 580050003017 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 580050003018 non-specific DNA binding site [nucleotide binding]; other site 580050003019 salt bridge; other site 580050003020 sequence-specific DNA binding site [nucleotide binding]; other site 580050003021 adenosine deaminase; Provisional; Region: PRK09358 580050003022 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 580050003023 active site 580050003024 Chorismate mutase type II; Region: CM_2; cl00693 580050003025 hypothetical protein; Provisional; Region: PRK06761 580050003026 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 580050003027 Coenzyme A binding pocket [chemical binding]; other site 580050003028 AAA domain; Region: AAA_17; pfam13207 580050003029 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 580050003030 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 580050003031 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 580050003032 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 580050003033 G1 box; other site 580050003034 putative GEF interaction site [polypeptide binding]; other site 580050003035 GTP/Mg2+ binding site [chemical binding]; other site 580050003036 Switch I region; other site 580050003037 G2 box; other site 580050003038 G3 box; other site 580050003039 Switch II region; other site 580050003040 G4 box; other site 580050003041 G5 box; other site 580050003042 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 580050003043 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 580050003044 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 580050003045 Transposase domain (DUF772); Region: DUF772; pfam05598 580050003046 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 580050003047 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 580050003048 GMP synthase; Reviewed; Region: guaA; PRK00074 580050003049 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 580050003050 AMP/PPi binding site [chemical binding]; other site 580050003051 candidate oxyanion hole; other site 580050003052 catalytic triad [active] 580050003053 potential glutamine specificity residues [chemical binding]; other site 580050003054 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 580050003055 ATP Binding subdomain [chemical binding]; other site 580050003056 Ligand Binding sites [chemical binding]; other site 580050003057 Dimerization subdomain; other site 580050003058 putative phosphoketolase; Provisional; Region: PRK05261 580050003059 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 580050003060 TPP-binding site; other site 580050003061 XFP C-terminal domain; Region: XFP_C; pfam09363 580050003062 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 580050003063 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 580050003064 propionate/acetate kinase; Provisional; Region: PRK12379 580050003065 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 580050003066 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 580050003067 hinge; other site 580050003068 active site 580050003069 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 580050003070 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 580050003071 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 580050003072 active site 580050003073 catalytic site [active] 580050003074 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 580050003075 dimer interface [polypeptide binding]; other site 580050003076 ADP-ribose binding site [chemical binding]; other site 580050003077 active site 580050003078 nudix motif; other site 580050003079 metal binding site [ion binding]; metal-binding site 580050003080 Uncharacterized conserved protein [Function unknown]; Region: COG0327 580050003081 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 580050003082 DNA polymerase I; Provisional; Region: PRK05755 580050003083 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 580050003084 active site 580050003085 metal binding site 1 [ion binding]; metal-binding site 580050003086 putative 5' ssDNA interaction site; other site 580050003087 metal binding site 3; metal-binding site 580050003088 metal binding site 2 [ion binding]; metal-binding site 580050003089 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 580050003090 putative DNA binding site [nucleotide binding]; other site 580050003091 putative metal binding site [ion binding]; other site 580050003092 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 580050003093 active site 580050003094 substrate binding site [chemical binding]; other site 580050003095 catalytic site [active] 580050003096 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 580050003097 active site 580050003098 DNA binding site [nucleotide binding] 580050003099 catalytic site [active] 580050003100 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 580050003101 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580050003102 active site 580050003103 phosphorylation site [posttranslational modification] 580050003104 intermolecular recognition site; other site 580050003105 dimerization interface [polypeptide binding]; other site 580050003106 ANTAR domain; Region: ANTAR; pfam03861 580050003107 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 580050003108 dimer interface [polypeptide binding]; other site 580050003109 ADP-ribose binding site [chemical binding]; other site 580050003110 active site 580050003111 nudix motif; other site 580050003112 metal binding site [ion binding]; metal-binding site 580050003113 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 580050003114 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 580050003115 active site 580050003116 domain interfaces; other site 580050003117 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 580050003118 excinuclease ABC subunit B; Provisional; Region: PRK05298 580050003119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580050003120 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050003121 nucleotide binding region [chemical binding]; other site 580050003122 ATP-binding site [chemical binding]; other site 580050003123 Ultra-violet resistance protein B; Region: UvrB; pfam12344 580050003124 UvrB/uvrC motif; Region: UVR; pfam02151 580050003125 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 580050003126 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 580050003127 CoA-binding site [chemical binding]; other site 580050003128 ATP-binding [chemical binding]; other site 580050003129 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 580050003130 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 580050003131 RNA binding site [nucleotide binding]; other site 580050003132 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 580050003133 RNA binding site [nucleotide binding]; other site 580050003134 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 580050003135 RNA binding site [nucleotide binding]; other site 580050003136 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 580050003137 RNA binding site [nucleotide binding]; other site 580050003138 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 580050003139 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 580050003140 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 580050003141 homodimer interface [polypeptide binding]; other site 580050003142 NADP binding site [chemical binding]; other site 580050003143 substrate binding site [chemical binding]; other site 580050003144 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 580050003145 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 580050003146 intersubunit interface [polypeptide binding]; other site 580050003147 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 580050003148 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 580050003149 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 580050003150 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 580050003151 ABC-ATPase subunit interface; other site 580050003152 dimer interface [polypeptide binding]; other site 580050003153 putative PBP binding regions; other site 580050003154 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 580050003155 homotrimer interaction site [polypeptide binding]; other site 580050003156 zinc binding site [ion binding]; other site 580050003157 CDP-binding sites; other site 580050003158 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 580050003159 glycogen branching enzyme; Provisional; Region: PRK05402 580050003160 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 580050003161 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 580050003162 active site 580050003163 catalytic site [active] 580050003164 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 580050003165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 580050003166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580050003167 active site 580050003168 phosphorylation site [posttranslational modification] 580050003169 intermolecular recognition site; other site 580050003170 dimerization interface [polypeptide binding]; other site 580050003171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 580050003172 DNA binding site [nucleotide binding] 580050003173 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 580050003174 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 580050003175 dimerization interface [polypeptide binding]; other site 580050003176 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 580050003177 dimer interface [polypeptide binding]; other site 580050003178 phosphorylation site [posttranslational modification] 580050003179 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580050003180 ATP binding site [chemical binding]; other site 580050003181 Mg2+ binding site [ion binding]; other site 580050003182 G-X-G motif; other site 580050003183 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 580050003184 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 580050003185 active site 580050003186 Eukaryotic phosphomannomutase; Region: PMM; cl17107 580050003187 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 580050003188 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 580050003189 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 580050003190 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 580050003191 Transcriptional regulator [Transcription]; Region: LytR; COG1316 580050003192 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 580050003193 Transcription factor WhiB; Region: Whib; pfam02467 580050003194 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 580050003195 PAS fold; Region: PAS_4; pfam08448 580050003196 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 580050003197 Histidine kinase; Region: HisKA_2; pfam07568 580050003198 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580050003199 ATP binding site [chemical binding]; other site 580050003200 Mg2+ binding site [ion binding]; other site 580050003201 G-X-G motif; other site 580050003202 V-type ATP synthase subunit E; Provisional; Region: PRK01558 580050003203 Haemolysin-III related; Region: HlyIII; pfam03006 580050003204 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 580050003205 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 580050003206 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 580050003207 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 580050003208 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 580050003209 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 580050003210 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 580050003211 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 580050003212 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 580050003213 Protein of unknown function (DUF501); Region: DUF501; pfam04417 580050003214 Septum formation initiator; Region: DivIC; pfam04977 580050003215 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 580050003216 enolase; Provisional; Region: eno; PRK00077 580050003217 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 580050003218 dimer interface [polypeptide binding]; other site 580050003219 metal binding site [ion binding]; metal-binding site 580050003220 substrate binding pocket [chemical binding]; other site 580050003221 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 580050003222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050003223 dimer interface [polypeptide binding]; other site 580050003224 conserved gate region; other site 580050003225 putative PBP binding loops; other site 580050003226 ABC-ATPase subunit interface; other site 580050003227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 580050003228 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 580050003229 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 580050003230 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 580050003231 Walker A/P-loop; other site 580050003232 ATP binding site [chemical binding]; other site 580050003233 Q-loop/lid; other site 580050003234 ABC transporter signature motif; other site 580050003235 Walker B; other site 580050003236 D-loop; other site 580050003237 H-loop/switch region; other site 580050003238 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 580050003239 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 580050003240 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580050003241 ATP binding site [chemical binding]; other site 580050003242 putative Mg++ binding site [ion binding]; other site 580050003243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050003244 nucleotide binding region [chemical binding]; other site 580050003245 ATP-binding site [chemical binding]; other site 580050003246 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 580050003247 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 580050003248 putative active site [active] 580050003249 catalytic residue [active] 580050003250 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 580050003251 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 580050003252 Coenzyme A binding pocket [chemical binding]; other site 580050003253 Uncharacterized conserved protein [Function unknown]; Region: COG1615 580050003254 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 580050003255 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 580050003256 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 580050003257 Protein of unknown function (DUF466); Region: DUF466; cl01082 580050003258 carbon starvation protein A; Provisional; Region: PRK15015 580050003259 Carbon starvation protein CstA; Region: CstA; pfam02554 580050003260 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 580050003261 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050003262 H-loop/switch region; other site 580050003263 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050003264 ABC transporter signature motif; other site 580050003265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 580050003266 Q-loop/lid; other site 580050003267 ABC transporter signature motif; other site 580050003268 Walker B; other site 580050003269 D-loop; other site 580050003270 H-loop/switch region; other site 580050003271 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 580050003272 MarR family; Region: MarR_2; pfam12802 580050003273 Ubinuclein conserved middle domain; Region: UBN_AB; pfam14075 580050003274 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 580050003275 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 580050003276 Aspartase; Region: Aspartase; cd01357 580050003277 active sites [active] 580050003278 tetramer interface [polypeptide binding]; other site 580050003279 FeoA domain; Region: FeoA; pfam04023 580050003280 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 580050003281 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 580050003282 G1 box; other site 580050003283 GTP/Mg2+ binding site [chemical binding]; other site 580050003284 Switch I region; other site 580050003285 G2 box; other site 580050003286 G3 box; other site 580050003287 Switch II region; other site 580050003288 G4 box; other site 580050003289 G5 box; other site 580050003290 Nucleoside recognition; Region: Gate; pfam07670 580050003291 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 580050003292 Nucleoside recognition; Region: Gate; pfam07670 580050003293 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 580050003294 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 580050003295 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 580050003296 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 580050003297 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 580050003298 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 580050003299 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 580050003300 putative active site [active] 580050003301 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 580050003302 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 580050003303 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 580050003304 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 580050003305 catalytic triad [active] 580050003306 active site nucleophile [active] 580050003307 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 580050003308 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 580050003309 SelR domain; Region: SelR; pfam01641 580050003310 methionine sulfoxide reductase B; Provisional; Region: PRK00222 580050003311 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 580050003312 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 580050003313 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 580050003314 Soluble P-type ATPase [General function prediction only]; Region: COG4087 580050003315 Uncharacterized conserved protein [Function unknown]; Region: COG3350 580050003316 classical (c) SDRs; Region: SDR_c; cd05233 580050003317 NAD(P) binding site [chemical binding]; other site 580050003318 active site 580050003319 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 580050003320 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 580050003321 ATP binding site [chemical binding]; other site 580050003322 Mg++ binding site [ion binding]; other site 580050003323 motif III; other site 580050003324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050003325 nucleotide binding region [chemical binding]; other site 580050003326 ATP-binding site [chemical binding]; other site 580050003327 Predicted membrane protein [Function unknown]; Region: COG2855 580050003328 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 580050003329 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 580050003330 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 580050003331 substrate binding pocket [chemical binding]; other site 580050003332 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 580050003333 GTP-binding protein YchF; Reviewed; Region: PRK09601 580050003334 YchF GTPase; Region: YchF; cd01900 580050003335 G1 box; other site 580050003336 GTP/Mg2+ binding site [chemical binding]; other site 580050003337 Switch I region; other site 580050003338 G2 box; other site 580050003339 Switch II region; other site 580050003340 G3 box; other site 580050003341 G4 box; other site 580050003342 G5 box; other site 580050003343 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 580050003344 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 580050003345 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 580050003346 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 580050003347 Histidine kinase; Region: HisKA_3; pfam07730 580050003348 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580050003349 ATP binding site [chemical binding]; other site 580050003350 Mg2+ binding site [ion binding]; other site 580050003351 G-X-G motif; other site 580050003352 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 580050003353 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580050003354 active site 580050003355 phosphorylation site [posttranslational modification] 580050003356 intermolecular recognition site; other site 580050003357 dimerization interface [polypeptide binding]; other site 580050003358 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 580050003359 DNA binding residues [nucleotide binding] 580050003360 dimerization interface [polypeptide binding]; other site 580050003361 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 580050003362 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 580050003363 FtsX-like permease family; Region: FtsX; pfam02687 580050003364 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 580050003365 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 580050003366 Walker A/P-loop; other site 580050003367 ATP binding site [chemical binding]; other site 580050003368 Q-loop/lid; other site 580050003369 ABC transporter signature motif; other site 580050003370 Walker B; other site 580050003371 D-loop; other site 580050003372 H-loop/switch region; other site 580050003373 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 580050003374 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 580050003375 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 580050003376 Walker A/P-loop; other site 580050003377 ATP binding site [chemical binding]; other site 580050003378 Q-loop/lid; other site 580050003379 ABC transporter signature motif; other site 580050003380 Walker B; other site 580050003381 D-loop; other site 580050003382 H-loop/switch region; other site 580050003383 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 580050003384 Walker A/P-loop; other site 580050003385 ATP binding site [chemical binding]; other site 580050003386 Q-loop/lid; other site 580050003387 ABC transporter signature motif; other site 580050003388 Walker B; other site 580050003389 D-loop; other site 580050003390 H-loop/switch region; other site 580050003391 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 580050003392 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 580050003393 homodimer interface [polypeptide binding]; other site 580050003394 substrate-cofactor binding pocket; other site 580050003395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050003396 catalytic residue [active] 580050003397 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 580050003398 dimer interface [polypeptide binding]; other site 580050003399 pyridoxal binding site [chemical binding]; other site 580050003400 ATP binding site [chemical binding]; other site 580050003401 hypothetical protein; Provisional; Region: PRK14681 580050003402 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 580050003403 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 580050003404 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050003405 Walker A motif; other site 580050003406 ATP binding site [chemical binding]; other site 580050003407 Walker B motif; other site 580050003408 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 580050003409 DNA protecting protein DprA; Region: dprA; TIGR00732 580050003410 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 580050003411 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 580050003412 L-aspartate oxidase; Provisional; Region: PRK06175 580050003413 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 580050003414 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 580050003415 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 580050003416 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 580050003417 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580050003418 S-adenosylmethionine binding site [chemical binding]; other site 580050003419 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 580050003420 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 580050003421 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 580050003422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050003423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050003424 homodimer interface [polypeptide binding]; other site 580050003425 catalytic residue [active] 580050003426 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 580050003427 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 580050003428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050003429 Walker A motif; other site 580050003430 ATP binding site [chemical binding]; other site 580050003431 Walker B motif; other site 580050003432 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 580050003433 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 580050003434 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 580050003435 oligomer interface [polypeptide binding]; other site 580050003436 active site residues [active] 580050003437 Clp protease; Region: CLP_protease; pfam00574 580050003438 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 580050003439 oligomer interface [polypeptide binding]; other site 580050003440 active site residues [active] 580050003441 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 580050003442 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 580050003443 putative ion selectivity filter; other site 580050003444 putative pore gating glutamate residue; other site 580050003445 trigger factor; Provisional; Region: tig; PRK01490 580050003446 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 580050003447 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 580050003448 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 580050003449 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 580050003450 active site 580050003451 catalytic site [active] 580050003452 substrate binding site [chemical binding]; other site 580050003453 HRDC domain; Region: HRDC; pfam00570 580050003454 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 580050003455 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 580050003456 FeS/SAM binding site; other site 580050003457 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 580050003458 Pyruvate formate lyase 1; Region: PFL1; cd01678 580050003459 coenzyme A binding site [chemical binding]; other site 580050003460 active site 580050003461 catalytic residues [active] 580050003462 glycine loop; other site 580050003463 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 580050003464 NAD synthetase; Provisional; Region: PRK13981 580050003465 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 580050003466 multimer interface [polypeptide binding]; other site 580050003467 active site 580050003468 catalytic triad [active] 580050003469 protein interface 1 [polypeptide binding]; other site 580050003470 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 580050003471 homodimer interface [polypeptide binding]; other site 580050003472 NAD binding pocket [chemical binding]; other site 580050003473 ATP binding pocket [chemical binding]; other site 580050003474 Mg binding site [ion binding]; other site 580050003475 active-site loop [active] 580050003476 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 580050003477 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 580050003478 metal binding site [ion binding]; metal-binding site 580050003479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050003480 conserved gate region; other site 580050003481 ABC-ATPase subunit interface; other site 580050003482 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 580050003483 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 580050003484 Walker A/P-loop; other site 580050003485 ATP binding site [chemical binding]; other site 580050003486 Q-loop/lid; other site 580050003487 ABC transporter signature motif; other site 580050003488 Walker B; other site 580050003489 D-loop; other site 580050003490 H-loop/switch region; other site 580050003491 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 580050003492 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 580050003493 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 580050003494 active site 580050003495 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 580050003496 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 580050003497 Zn2+ binding site [ion binding]; other site 580050003498 Mg2+ binding site [ion binding]; other site 580050003499 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 580050003500 synthetase active site [active] 580050003501 NTP binding site [chemical binding]; other site 580050003502 metal binding site [ion binding]; metal-binding site 580050003503 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 580050003504 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 580050003505 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 580050003506 trimer interface [polypeptide binding]; other site 580050003507 active site 580050003508 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 580050003509 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 580050003510 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 580050003511 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 580050003512 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 580050003513 CAP-like domain; other site 580050003514 active site 580050003515 primary dimer interface [polypeptide binding]; other site 580050003516 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 580050003517 EamA-like transporter family; Region: EamA; cl17759 580050003518 DEAD-like helicases superfamily; Region: DEXDc; smart00487 580050003519 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580050003520 ATP binding site [chemical binding]; other site 580050003521 putative Mg++ binding site [ion binding]; other site 580050003522 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 580050003523 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050003524 nucleotide binding region [chemical binding]; other site 580050003525 ATP-binding site [chemical binding]; other site 580050003526 DEAD/H associated; Region: DEAD_assoc; pfam08494 580050003527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050003528 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050003529 putative substrate translocation pore; other site 580050003530 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 580050003531 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 580050003532 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 580050003533 ATP binding site [chemical binding]; other site 580050003534 Mg2+ binding site [ion binding]; other site 580050003535 G-X-G motif; other site 580050003536 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 580050003537 anchoring element; other site 580050003538 dimer interface [polypeptide binding]; other site 580050003539 ATP binding site [chemical binding]; other site 580050003540 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 580050003541 active site 580050003542 putative metal-binding site [ion binding]; other site 580050003543 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 580050003544 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 580050003545 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 580050003546 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 580050003547 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 580050003548 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 580050003549 DNA binding residues [nucleotide binding] 580050003550 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 580050003551 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 580050003552 substrate binding pocket [chemical binding]; other site 580050003553 chain length determination region; other site 580050003554 substrate-Mg2+ binding site; other site 580050003555 catalytic residues [active] 580050003556 aspartate-rich region 1; other site 580050003557 active site lid residues [active] 580050003558 aspartate-rich region 2; other site 580050003559 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 580050003560 Catalytic domain of Protein Kinases; Region: PKc; cd00180 580050003561 active site 580050003562 ATP binding site [chemical binding]; other site 580050003563 substrate binding site [chemical binding]; other site 580050003564 activation loop (A-loop); other site 580050003565 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 580050003566 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 580050003567 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 580050003568 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 580050003569 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 580050003570 putative acyl-acceptor binding pocket; other site 580050003571 TrbC/VIRB2 family; Region: TrbC; pfam04956 580050003572 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 580050003573 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 580050003574 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 580050003575 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 580050003576 DEAD/DEAH box helicase; Region: DEAD; pfam00270 580050003577 ATP binding site [chemical binding]; other site 580050003578 putative Mg++ binding site [ion binding]; other site 580050003579 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 580050003580 SEC-C motif; Region: SEC-C; pfam02810 580050003581 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 580050003582 30S subunit binding site; other site 580050003583 RecX family; Region: RecX; pfam02631 580050003584 recombinase A; Provisional; Region: recA; PRK09354 580050003585 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 580050003586 hexamer interface [polypeptide binding]; other site 580050003587 Walker A motif; other site 580050003588 ATP binding site [chemical binding]; other site 580050003589 Walker B motif; other site 580050003590 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 580050003591 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 580050003592 non-specific DNA binding site [nucleotide binding]; other site 580050003593 salt bridge; other site 580050003594 sequence-specific DNA binding site [nucleotide binding]; other site 580050003595 Competence-damaged protein; Region: CinA; pfam02464 580050003596 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 580050003597 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 580050003598 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 580050003599 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 580050003600 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 580050003601 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 580050003602 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 580050003603 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 580050003604 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 580050003605 FeS/SAM binding site; other site 580050003606 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 580050003607 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 580050003608 synthetase active site [active] 580050003609 NTP binding site [chemical binding]; other site 580050003610 metal binding site [ion binding]; metal-binding site 580050003611 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 580050003612 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 580050003613 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 580050003614 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 580050003615 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 580050003616 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 580050003617 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050003618 Walker A/P-loop; other site 580050003619 ATP binding site [chemical binding]; other site 580050003620 Q-loop/lid; other site 580050003621 ABC transporter signature motif; other site 580050003622 Walker B; other site 580050003623 D-loop; other site 580050003624 H-loop/switch region; other site 580050003625 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 580050003626 Histidine kinase; Region: HisKA_3; pfam07730 580050003627 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 580050003628 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580050003629 active site 580050003630 phosphorylation site [posttranslational modification] 580050003631 intermolecular recognition site; other site 580050003632 dimerization interface [polypeptide binding]; other site 580050003633 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 580050003634 DNA binding residues [nucleotide binding] 580050003635 dimerization interface [polypeptide binding]; other site 580050003636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 580050003637 Transposase; Region: DDE_Tnp_ISL3; pfam01610 580050003638 Protein of unknown function DUF262; Region: DUF262; pfam03235 580050003639 Uncharacterized conserved protein [Function unknown]; Region: COG1479 580050003640 Protein of unknown function DUF262; Region: DUF262; pfam03235 580050003641 maltose O-acetyltransferase; Provisional; Region: PRK10092 580050003642 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 580050003643 active site 580050003644 substrate binding site [chemical binding]; other site 580050003645 trimer interface [polypeptide binding]; other site 580050003646 CoA binding site [chemical binding]; other site 580050003647 aconitate hydratase; Validated; Region: PRK09277 580050003648 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 580050003649 substrate binding site [chemical binding]; other site 580050003650 ligand binding site [chemical binding]; other site 580050003651 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 580050003652 substrate binding site [chemical binding]; other site 580050003653 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 580050003654 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 580050003655 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 580050003656 Soluble P-type ATPase [General function prediction only]; Region: COG4087 580050003657 Protein of unknown function (DUF418); Region: DUF418; cl12135 580050003658 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 580050003659 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 580050003660 TRAM domain; Region: TRAM; cl01282 580050003661 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 580050003662 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 580050003663 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 580050003664 putative active site [active] 580050003665 putative catalytic site [active] 580050003666 putative DNA binding site [nucleotide binding]; other site 580050003667 putative phosphate binding site [ion binding]; other site 580050003668 metal binding site A [ion binding]; metal-binding site 580050003669 putative AP binding site [nucleotide binding]; other site 580050003670 putative metal binding site B [ion binding]; other site 580050003671 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 580050003672 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580050003673 AAA domain; Region: AAA_21; pfam13304 580050003674 Walker A/P-loop; other site 580050003675 ATP binding site [chemical binding]; other site 580050003676 Q-loop/lid; other site 580050003677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580050003678 ABC transporter signature motif; other site 580050003679 Walker B; other site 580050003680 D-loop; other site 580050003681 H-loop/switch region; other site 580050003682 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 580050003683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580050003684 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 580050003685 Walker A/P-loop; other site 580050003686 ATP binding site [chemical binding]; other site 580050003687 Q-loop/lid; other site 580050003688 ABC transporter signature motif; other site 580050003689 Walker B; other site 580050003690 D-loop; other site 580050003691 H-loop/switch region; other site 580050003692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 580050003693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050003694 dimer interface [polypeptide binding]; other site 580050003695 conserved gate region; other site 580050003696 putative PBP binding loops; other site 580050003697 ABC-ATPase subunit interface; other site 580050003698 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 580050003699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050003700 dimer interface [polypeptide binding]; other site 580050003701 conserved gate region; other site 580050003702 putative PBP binding loops; other site 580050003703 ABC-ATPase subunit interface; other site 580050003704 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 580050003705 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 580050003706 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 580050003707 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 580050003708 active site 580050003709 DNA binding site [nucleotide binding] 580050003710 Int/Topo IB signature motif; other site 580050003711 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 580050003712 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 580050003713 Walker A/P-loop; other site 580050003714 ATP binding site [chemical binding]; other site 580050003715 Q-loop/lid; other site 580050003716 ABC transporter signature motif; other site 580050003717 Walker B; other site 580050003718 D-loop; other site 580050003719 H-loop/switch region; other site 580050003720 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 580050003721 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 580050003722 FtsX-like permease family; Region: FtsX; pfam02687 580050003723 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 580050003724 FtsX-like permease family; Region: FtsX; pfam02687 580050003725 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 580050003726 prephenate dehydrogenase; Validated; Region: PRK08507 580050003727 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 580050003728 Prephenate dehydratase; Region: PDT; pfam00800 580050003729 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 580050003730 putative L-Phe binding site [chemical binding]; other site 580050003731 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 580050003732 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 580050003733 G1 box; other site 580050003734 putative GEF interaction site [polypeptide binding]; other site 580050003735 GTP/Mg2+ binding site [chemical binding]; other site 580050003736 Switch I region; other site 580050003737 G2 box; other site 580050003738 G3 box; other site 580050003739 Switch II region; other site 580050003740 G4 box; other site 580050003741 G5 box; other site 580050003742 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 580050003743 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 580050003744 benzoate transport; Region: 2A0115; TIGR00895 580050003745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050003746 putative substrate translocation pore; other site 580050003747 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 580050003748 nudix motif; other site 580050003749 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 580050003750 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 580050003751 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 580050003752 P-loop; other site 580050003753 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 580050003754 Magnesium ion binding site [ion binding]; other site 580050003755 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 580050003756 Magnesium ion binding site [ion binding]; other site 580050003757 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 580050003758 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 580050003759 active site 580050003760 Int/Topo IB signature motif; other site 580050003761 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 580050003762 23S rRNA binding site [nucleotide binding]; other site 580050003763 L21 binding site [polypeptide binding]; other site 580050003764 L13 binding site [polypeptide binding]; other site 580050003765 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 580050003766 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 580050003767 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 580050003768 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 580050003769 Thiamine pyrophosphokinase; Region: TPK; cd07995 580050003770 active site 580050003771 dimerization interface [polypeptide binding]; other site 580050003772 thiamine binding site [chemical binding]; other site 580050003773 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 580050003774 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 580050003775 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 580050003776 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 580050003777 putative deacylase active site [active] 580050003778 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 580050003779 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 580050003780 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 580050003781 active site 580050003782 catalytic residues [active] 580050003783 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 580050003784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 580050003785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 580050003786 DNA binding residues [nucleotide binding] 580050003787 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 580050003788 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 580050003789 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580050003790 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 580050003791 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 580050003792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 580050003793 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 580050003794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580050003795 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 580050003796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 580050003797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 580050003798 active site 580050003799 phosphorylation site [posttranslational modification] 580050003800 intermolecular recognition site; other site 580050003801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 580050003802 DNA binding residues [nucleotide binding] 580050003803 dimerization interface [polypeptide binding]; other site 580050003804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 580050003805 Histidine kinase; Region: HisKA_3; pfam07730 580050003806 proline aminopeptidase P II; Provisional; Region: PRK10879 580050003807 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 580050003808 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 580050003809 active site 580050003810 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 580050003811 nudix motif; other site 580050003812 MarR family; Region: MarR_2; cl17246 580050003813 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 580050003814 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 580050003815 nucleotide binding site [chemical binding]; other site 580050003816 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 580050003817 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 580050003818 putative substrate binding site [chemical binding]; other site 580050003819 putative ATP binding site [chemical binding]; other site 580050003820 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 580050003821 putative active site [active] 580050003822 dimerization interface [polypeptide binding]; other site 580050003823 putative tRNAtyr binding site [nucleotide binding]; other site 580050003824 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 580050003825 active site 580050003826 DNA binding site [nucleotide binding] 580050003827 Int/Topo IB signature motif; other site 580050003828 Helix-turn-helix domain; Region: HTH_17; pfam12728 580050003829 Helix-turn-helix domain; Region: HTH_17; pfam12728 580050003830 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 580050003831 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 580050003832 Walker A motif; other site 580050003833 ATP binding site [chemical binding]; other site 580050003834 Walker B motif; other site 580050003835 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 580050003836 Phage capsid family; Region: Phage_capsid; pfam05065 580050003837 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 580050003838 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580050003839 Walker A/P-loop; other site 580050003840 ATP binding site [chemical binding]; other site 580050003841 Q-loop/lid; other site 580050003842 ABC transporter signature motif; other site 580050003843 Walker B; other site 580050003844 D-loop; other site 580050003845 H-loop/switch region; other site 580050003846 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 580050003847 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 580050003848 Walker A/P-loop; other site 580050003849 ATP binding site [chemical binding]; other site 580050003850 Q-loop/lid; other site 580050003851 ABC transporter signature motif; other site 580050003852 Walker B; other site 580050003853 D-loop; other site 580050003854 H-loop/switch region; other site 580050003855 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 580050003856 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 580050003857 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 580050003858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050003859 dimer interface [polypeptide binding]; other site 580050003860 conserved gate region; other site 580050003861 ABC-ATPase subunit interface; other site 580050003862 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 580050003863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050003864 dimer interface [polypeptide binding]; other site 580050003865 conserved gate region; other site 580050003866 putative PBP binding loops; other site 580050003867 ABC-ATPase subunit interface; other site 580050003868 potential frameshift: common BLAST hit:gi|189439074|ref|YP_001954155.1| ABC-type dipeptidetransport system periplasmic component 580050003869 cell division protein FtsQ; Provisional; Region: PRK05529 580050003870 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 580050003871 Cell division protein FtsQ; Region: FtsQ; pfam03799 580050003872 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 580050003873 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 580050003874 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580050003875 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 580050003876 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 580050003877 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 580050003878 active site 580050003879 homodimer interface [polypeptide binding]; other site 580050003880 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 580050003881 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 580050003882 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 580050003883 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580050003884 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 580050003885 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 580050003886 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 580050003887 Mg++ binding site [ion binding]; other site 580050003888 putative catalytic motif [active] 580050003889 putative substrate binding site [chemical binding]; other site 580050003890 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 580050003891 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 580050003892 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 580050003893 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 580050003894 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 580050003895 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 580050003896 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 580050003897 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 580050003898 MraW methylase family; Region: Methyltransf_5; cl17771 580050003899 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 580050003900 MraZ protein; Region: MraZ; pfam02381 580050003901 cell division protein MraZ; Reviewed; Region: PRK00326 580050003902 MraZ protein; Region: MraZ; pfam02381 580050003903 Part of AAA domain; Region: AAA_19; pfam13245 580050003904 Family description; Region: UvrD_C_2; pfam13538 580050003905 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 580050003906 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 580050003907 ligand binding site [chemical binding]; other site 580050003908 NAD binding site [chemical binding]; other site 580050003909 tetramer interface [polypeptide binding]; other site 580050003910 catalytic site [active] 580050003911 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 580050003912 L-serine binding site [chemical binding]; other site 580050003913 ACT domain interface; other site 580050003914 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 580050003915 ATP cone domain; Region: ATP-cone; pfam03477 580050003916 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 580050003917 LexA repressor; Validated; Region: PRK00215 580050003918 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 580050003919 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 580050003920 Catalytic site [active] 580050003921 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 580050003922 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 580050003923 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 580050003924 NAD binding site [chemical binding]; other site 580050003925 dimer interface [polypeptide binding]; other site 580050003926 substrate binding site [chemical binding]; other site 580050003927 tetramer (dimer of dimers) interface [polypeptide binding]; other site 580050003928 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 580050003929 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 580050003930 HflX GTPase family; Region: HflX; cd01878 580050003931 G1 box; other site 580050003932 GTP/Mg2+ binding site [chemical binding]; other site 580050003933 Switch I region; other site 580050003934 G2 box; other site 580050003935 G3 box; other site 580050003936 Switch II region; other site 580050003937 G4 box; other site 580050003938 G5 box; other site 580050003939 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 580050003940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 580050003941 S-adenosylmethionine binding site [chemical binding]; other site 580050003942 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 580050003943 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 580050003944 ATP binding site [chemical binding]; other site 580050003945 putative Mg++ binding site [ion binding]; other site 580050003946 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 580050003947 nucleotide binding region [chemical binding]; other site 580050003948 ATP-binding site [chemical binding]; other site 580050003949 Helicase associated domain (HA2); Region: HA2; pfam04408 580050003950 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 580050003951 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 580050003952 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 580050003953 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 580050003954 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 580050003955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 580050003956 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 580050003957 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 580050003958 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 580050003959 catalytic residues [active] 580050003960 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 580050003961 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 580050003962 putative active site [active] 580050003963 oxyanion strand; other site 580050003964 catalytic triad [active] 580050003965 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 580050003966 putative active site pocket [active] 580050003967 4-fold oligomerization interface [polypeptide binding]; other site 580050003968 metal binding residues [ion binding]; metal-binding site 580050003969 3-fold/trimer interface [polypeptide binding]; other site 580050003970 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 580050003971 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050003972 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050003973 homodimer interface [polypeptide binding]; other site 580050003974 catalytic residue [active] 580050003975 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 580050003976 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 580050003977 NAD binding site [chemical binding]; other site 580050003978 dimerization interface [polypeptide binding]; other site 580050003979 product binding site; other site 580050003980 substrate binding site [chemical binding]; other site 580050003981 zinc binding site [ion binding]; other site 580050003982 catalytic residues [active] 580050003983 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 580050003984 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 580050003985 active site 580050003986 PHP Thumb interface [polypeptide binding]; other site 580050003987 metal binding site [ion binding]; metal-binding site 580050003988 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 580050003989 generic binding surface I; other site 580050003990 generic binding surface II; other site 580050003991 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 580050003992 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 580050003993 RNA binding surface [nucleotide binding]; other site 580050003994 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 580050003995 active site 580050003996 lipoprotein signal peptidase; Provisional; Region: PRK14771 580050003997 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 580050003998 YGGT family; Region: YGGT; pfam02325 580050003999 Protein of unknown function (DUF552); Region: DUF552; pfam04472 580050004000 cell division protein FtsZ; Validated; Region: PRK09330 580050004001 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 580050004002 nucleotide binding site [chemical binding]; other site 580050004003 SulA interaction site; other site 580050004004 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 580050004005 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 580050004006 FMN binding site [chemical binding]; other site 580050004007 active site 580050004008 catalytic residues [active] 580050004009 substrate binding site [chemical binding]; other site 580050004010 glycyl-tRNA synthetase; Provisional; Region: PRK04173 580050004011 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 580050004012 motif 1; other site 580050004013 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 580050004014 active site 580050004015 motif 2; other site 580050004016 motif 3; other site 580050004017 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 580050004018 anticodon binding site; other site 580050004019 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 580050004020 substrate binding site [chemical binding]; other site 580050004021 multimerization interface [polypeptide binding]; other site 580050004022 ATP binding site [chemical binding]; other site 580050004023 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 580050004024 thiamine phosphate binding site [chemical binding]; other site 580050004025 active site 580050004026 pyrophosphate binding site [ion binding]; other site 580050004027 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 580050004028 substrate binding site [chemical binding]; other site 580050004029 dimer interface [polypeptide binding]; other site 580050004030 ATP binding site [chemical binding]; other site 580050004031 Domain of unknown function DUF77; Region: DUF77; pfam01910 580050004032 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050004033 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050004034 DNA binding site [nucleotide binding] 580050004035 domain linker motif; other site 580050004036 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 580050004037 putative dimerization interface [polypeptide binding]; other site 580050004038 putative ligand binding site [chemical binding]; other site 580050004039 galactoside permease; Reviewed; Region: lacY; PRK09528 580050004040 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050004041 putative substrate translocation pore; other site 580050004042 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 580050004043 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 580050004044 substrate binding [chemical binding]; other site 580050004045 active site 580050004046 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 580050004047 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 580050004048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050004049 dimer interface [polypeptide binding]; other site 580050004050 conserved gate region; other site 580050004051 putative PBP binding loops; other site 580050004052 ABC-ATPase subunit interface; other site 580050004053 NMT1/THI5 like; Region: NMT1; pfam09084 580050004054 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 580050004055 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 580050004056 active site 580050004057 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 580050004058 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 580050004059 catalytic residue [active] 580050004060 putative FPP diphosphate binding site; other site 580050004061 putative FPP binding hydrophobic cleft; other site 580050004062 dimer interface [polypeptide binding]; other site 580050004063 putative IPP diphosphate binding site; other site 580050004064 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 580050004065 Recombination protein O N terminal; Region: RecO_N; pfam11967 580050004066 Recombination protein O C terminal; Region: RecO_C; pfam02565 580050004067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 580050004068 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 580050004069 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 580050004070 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 580050004071 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 580050004072 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 580050004073 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 580050004074 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 580050004075 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 580050004076 DivIVA domain; Region: DivI1A_domain; TIGR03544 580050004077 DivIVA domain; Region: DivI1A_domain; TIGR03544 580050004078 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 580050004079 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 580050004080 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 580050004081 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 580050004082 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 580050004083 Part of AAA domain; Region: AAA_19; pfam13245 580050004084 Family description; Region: UvrD_C_2; pfam13538 580050004085 Phosphotransferase enzyme family; Region: APH; pfam01636 580050004086 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 580050004087 substrate binding site [chemical binding]; other site 580050004088 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 580050004089 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 580050004090 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 580050004091 active site 580050004092 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 580050004093 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 580050004094 putative active site [active] 580050004095 redox center [active] 580050004096 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 580050004097 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 580050004098 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 580050004099 glutamate racemase; Provisional; Region: PRK00865 580050004100 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 580050004101 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 580050004102 active site 580050004103 nucleophile elbow; other site 580050004104 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 580050004105 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 580050004106 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 580050004107 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 580050004108 substrate binding pocket [chemical binding]; other site 580050004109 membrane-bound complex binding site; other site 580050004110 hinge residues; other site 580050004111 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 580050004112 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050004113 Walker A/P-loop; other site 580050004114 ATP binding site [chemical binding]; other site 580050004115 Q-loop/lid; other site 580050004116 ABC transporter signature motif; other site 580050004117 Walker B; other site 580050004118 D-loop; other site 580050004119 H-loop/switch region; other site 580050004120 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 580050004121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050004122 dimer interface [polypeptide binding]; other site 580050004123 conserved gate region; other site 580050004124 putative PBP binding loops; other site 580050004125 ABC-ATPase subunit interface; other site 580050004126 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 580050004127 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050004128 dimer interface [polypeptide binding]; other site 580050004129 conserved gate region; other site 580050004130 putative PBP binding loops; other site 580050004131 ABC-ATPase subunit interface; other site 580050004132 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 580050004133 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050004134 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050004135 homodimer interface [polypeptide binding]; other site 580050004136 catalytic residue [active] 580050004137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050004138 putative PBP binding loops; other site 580050004139 ABC-ATPase subunit interface; other site 580050004140 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 580050004141 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 580050004142 Walker A/P-loop; other site 580050004143 ATP binding site [chemical binding]; other site 580050004144 Q-loop/lid; other site 580050004145 ABC transporter signature motif; other site 580050004146 Walker B; other site 580050004147 D-loop; other site 580050004148 H-loop/switch region; other site 580050004149 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 580050004150 NIL domain; Region: NIL; pfam09383 580050004151 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 580050004152 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 580050004153 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 580050004154 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 580050004155 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 580050004156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 580050004157 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 580050004158 active site 580050004159 catalytic site [active] 580050004160 substrate binding site [chemical binding]; other site 580050004161 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 580050004162 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 580050004163 G1 box; other site 580050004164 putative GEF interaction site [polypeptide binding]; other site 580050004165 GTP/Mg2+ binding site [chemical binding]; other site 580050004166 Switch I region; other site 580050004167 G2 box; other site 580050004168 G3 box; other site 580050004169 Switch II region; other site 580050004170 G4 box; other site 580050004171 G5 box; other site 580050004172 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 580050004173 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 580050004174 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 580050004175 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 580050004176 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 580050004177 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 580050004178 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050004179 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050004180 putative substrate translocation pore; other site 580050004181 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 580050004182 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 580050004183 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 580050004184 HIGH motif; other site 580050004185 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 580050004186 active site 580050004187 KMSKS motif; other site 580050004188 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 580050004189 tRNA binding surface [nucleotide binding]; other site 580050004190 anticodon binding site; other site 580050004191 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 580050004192 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 580050004193 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 580050004194 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 580050004195 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 580050004196 Walker A/P-loop; other site 580050004197 ATP binding site [chemical binding]; other site 580050004198 Q-loop/lid; other site 580050004199 ABC transporter signature motif; other site 580050004200 Walker B; other site 580050004201 D-loop; other site 580050004202 H-loop/switch region; other site 580050004203 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 580050004204 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 580050004205 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050004206 Walker A/P-loop; other site 580050004207 ATP binding site [chemical binding]; other site 580050004208 Q-loop/lid; other site 580050004209 ABC transporter signature motif; other site 580050004210 Walker B; other site 580050004211 D-loop; other site 580050004212 H-loop/switch region; other site 580050004213 MarR family; Region: MarR_2; pfam12802 580050004214 Transcriptional regulators [Transcription]; Region: MarR; COG1846 580050004215 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 580050004216 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 580050004217 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 580050004218 mismatch recognition site; other site 580050004219 additional DNA contacts [nucleotide binding]; other site 580050004220 active site 580050004221 zinc binding site [ion binding]; other site 580050004222 DNA intercalation site [nucleotide binding]; other site 580050004223 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 580050004224 FIC domain binding interface [polypeptide binding]; other site 580050004225 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 580050004226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 580050004227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 580050004228 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 580050004229 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 580050004230 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 580050004231 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 580050004232 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 580050004233 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 580050004234 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 580050004235 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 580050004236 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 580050004237 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 580050004238 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 580050004239 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 580050004240 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 580050004241 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 580050004242 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 580050004243 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 580050004244 FeS/SAM binding site; other site 580050004245 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 580050004246 ATP cone domain; Region: ATP-cone; pfam03477 580050004247 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 580050004248 Class III ribonucleotide reductase; Region: RNR_III; cd01675 580050004249 active site 580050004250 Zn binding site [ion binding]; other site 580050004251 glycine loop; other site 580050004252 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 580050004253 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 580050004254 generic binding surface II; other site 580050004255 generic binding surface I; other site 580050004256 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 580050004257 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 580050004258 putative catalytic site [active] 580050004259 putative metal binding site [ion binding]; other site 580050004260 putative phosphate binding site [ion binding]; other site 580050004261 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 580050004262 aminotransferase; Validated; Region: PRK07337 580050004263 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 580050004264 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050004265 homodimer interface [polypeptide binding]; other site 580050004266 catalytic residue [active] 580050004267 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 580050004268 additional DNA contacts [nucleotide binding]; other site 580050004269 mismatch recognition site; other site 580050004270 active site 580050004271 zinc binding site [ion binding]; other site 580050004272 DNA intercalation site [nucleotide binding]; other site 580050004273 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 580050004274 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 580050004275 active site 580050004276 catalytic site [active] 580050004277 substrate binding site [chemical binding]; other site 580050004278 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 580050004279 active site 580050004280 catalytic residues [active] 580050004281 metal binding site [ion binding]; metal-binding site 580050004282 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 580050004283 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 580050004284 active site 580050004285 substrate binding site [chemical binding]; other site 580050004286 metal binding site [ion binding]; metal-binding site 580050004287 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 580050004288 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 580050004289 Zn binding site [ion binding]; other site 580050004290 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 580050004291 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 580050004292 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 580050004293 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 580050004294 dihydrodipicolinate synthase; Region: dapA; TIGR00674 580050004295 dimer interface [polypeptide binding]; other site 580050004296 active site 580050004297 catalytic residue [active] 580050004298 dihydrodipicolinate reductase; Provisional; Region: PRK00048 580050004299 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 580050004300 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 580050004301 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050004302 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050004303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 580050004304 Coenzyme A binding pocket [chemical binding]; other site 580050004305 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 580050004306 Family description; Region: UvrD_C_2; pfam13538 580050004307 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 580050004308 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 580050004309 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 580050004310 Catalytic domain of Protein Kinases; Region: PKc; cd00180 580050004311 active site 580050004312 ATP binding site [chemical binding]; other site 580050004313 substrate binding site [chemical binding]; other site 580050004314 activation loop (A-loop); other site 580050004315 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 580050004316 Interdomain contacts; other site 580050004317 Cytokine receptor motif; other site 580050004318 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 580050004319 Interdomain contacts; other site 580050004320 Cytokine receptor motif; other site 580050004321 MoxR-like ATPases [General function prediction only]; Region: COG0714 580050004322 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050004323 Walker A motif; other site 580050004324 ATP binding site [chemical binding]; other site 580050004325 Walker B motif; other site 580050004326 arginine finger; other site 580050004327 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 580050004328 Protein of unknown function DUF58; Region: DUF58; pfam01882 580050004329 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 580050004330 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 580050004331 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 580050004332 phosphopeptide binding site; other site 580050004333 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 580050004334 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 580050004335 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 580050004336 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 580050004337 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 580050004338 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 580050004339 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 580050004340 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 580050004341 DNA binding site [nucleotide binding] 580050004342 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 580050004343 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 580050004344 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 580050004345 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 580050004346 RPB1 interaction site [polypeptide binding]; other site 580050004347 RPB10 interaction site [polypeptide binding]; other site 580050004348 RPB11 interaction site [polypeptide binding]; other site 580050004349 RPB3 interaction site [polypeptide binding]; other site 580050004350 RPB12 interaction site [polypeptide binding]; other site 580050004351 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 580050004352 endonuclease III; Region: ENDO3c; smart00478 580050004353 minor groove reading motif; other site 580050004354 helix-hairpin-helix signature motif; other site 580050004355 substrate binding pocket [chemical binding]; other site 580050004356 active site 580050004357 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 580050004358 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 580050004359 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 580050004360 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 580050004361 active site 580050004362 catalytic site [active] 580050004363 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 580050004364 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 580050004365 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 580050004366 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 580050004367 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 580050004368 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 580050004369 dimer interface [polypeptide binding]; other site 580050004370 active site 580050004371 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 580050004372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 580050004373 DNA-binding site [nucleotide binding]; DNA binding site 580050004374 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 580050004375 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 580050004376 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 580050004377 Ligand binding site; other site 580050004378 Putative Catalytic site; other site 580050004379 DXD motif; other site 580050004380 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 580050004381 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 580050004382 quinone interaction residues [chemical binding]; other site 580050004383 active site 580050004384 catalytic residues [active] 580050004385 FMN binding site [chemical binding]; other site 580050004386 substrate binding site [chemical binding]; other site 580050004387 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 580050004388 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 580050004389 active site 580050004390 FMN binding site [chemical binding]; other site 580050004391 substrate binding site [chemical binding]; other site 580050004392 homotetramer interface [polypeptide binding]; other site 580050004393 catalytic residue [active] 580050004394 Transglycosylase; Region: Transgly; pfam00912 580050004395 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 580050004396 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 580050004397 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 580050004398 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 580050004399 ligand binding site [chemical binding]; other site 580050004400 flexible hinge region; other site 580050004401 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 580050004402 putative switch regulator; other site 580050004403 non-specific DNA interactions [nucleotide binding]; other site 580050004404 DNA binding site [nucleotide binding] 580050004405 sequence specific DNA binding site [nucleotide binding]; other site 580050004406 putative cAMP binding site [chemical binding]; other site 580050004407 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 580050004408 TM2 domain; Region: TM2; pfam05154 580050004409 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 580050004410 tartrate dehydrogenase; Region: TTC; TIGR02089 580050004411 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 580050004412 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 580050004413 Uncharacterized conserved protein [Function unknown]; Region: COG4850 580050004414 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 580050004415 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 580050004416 lipoyl attachment site [posttranslational modification]; other site 580050004417 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 580050004418 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 580050004419 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 580050004420 putative NADH binding site [chemical binding]; other site 580050004421 putative active site [active] 580050004422 nudix motif; other site 580050004423 putative metal binding site [ion binding]; other site 580050004424 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 580050004425 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 580050004426 nudix motif; other site 580050004427 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 580050004428 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 580050004429 catalytic residues [active] 580050004430 Domain of unknown function (DUF348); Region: DUF348; pfam03990 580050004431 G5 domain; Region: G5; pfam07501 580050004432 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 580050004433 N-acetyl-D-glucosamine binding site [chemical binding]; other site 580050004434 catalytic residue [active] 580050004435 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 580050004436 Bacterial sugar transferase; Region: Bac_transf; pfam02397 580050004437 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 580050004438 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 580050004439 Putative Catalytic site; other site 580050004440 DXD motif; other site 580050004441 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 580050004442 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 580050004443 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 580050004444 substrate binding site; other site 580050004445 tetramer interface; other site 580050004446 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 580050004447 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 580050004448 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 580050004449 NADP binding site [chemical binding]; other site 580050004450 active site 580050004451 putative substrate binding site [chemical binding]; other site 580050004452 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 580050004453 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 580050004454 NAD binding site [chemical binding]; other site 580050004455 substrate binding site [chemical binding]; other site 580050004456 homodimer interface [polypeptide binding]; other site 580050004457 active site 580050004458 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 580050004459 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 580050004460 Probable Catalytic site; other site 580050004461 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 580050004462 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 580050004463 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 580050004464 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580050004465 active site 580050004466 putative glycosyl transferase; Provisional; Region: PRK10073 580050004467 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 580050004468 active site 580050004469 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580050004470 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 580050004471 active site 580050004472 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 580050004473 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 580050004474 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 580050004475 active site 580050004476 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 580050004477 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 580050004478 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 580050004479 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 580050004480 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 580050004481 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 580050004482 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 580050004483 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580050004484 active site 580050004485 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 580050004486 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 580050004487 Bacterial sugar transferase; Region: Bac_transf; pfam02397 580050004488 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050004489 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050004490 putative substrate translocation pore; other site 580050004491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050004492 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 580050004493 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 580050004494 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 580050004495 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 580050004496 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 580050004497 active site 580050004498 multimer interface [polypeptide binding]; other site 580050004499 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 580050004500 predicted active site [active] 580050004501 catalytic triad [active] 580050004502 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 580050004503 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 580050004504 putative NAD(P) binding site [chemical binding]; other site 580050004505 active site 580050004506 putative substrate binding site [chemical binding]; other site 580050004507 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 580050004508 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 580050004509 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 580050004510 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580050004511 active site 580050004512 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 580050004513 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 580050004514 Ligand binding site; other site 580050004515 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 580050004516 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 580050004517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050004518 Walker A/P-loop; other site 580050004519 ATP binding site [chemical binding]; other site 580050004520 Q-loop/lid; other site 580050004521 ABC transporter signature motif; other site 580050004522 Walker B; other site 580050004523 D-loop; other site 580050004524 H-loop/switch region; other site 580050004525 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 580050004526 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050004527 Walker A/P-loop; other site 580050004528 ATP binding site [chemical binding]; other site 580050004529 Q-loop/lid; other site 580050004530 ABC transporter signature motif; other site 580050004531 Walker B; other site 580050004532 D-loop; other site 580050004533 H-loop/switch region; other site 580050004534 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 580050004535 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 580050004536 acyl-activating enzyme (AAE) consensus motif; other site 580050004537 putative AMP binding site [chemical binding]; other site 580050004538 putative active site [active] 580050004539 putative CoA binding site [chemical binding]; other site 580050004540 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 580050004541 putative active site [active] 580050004542 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 580050004543 dimer interface [polypeptide binding]; other site 580050004544 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 580050004545 nudix motif; other site 580050004546 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 580050004547 Low molecular weight phosphatase family; Region: LMWPc; cd00115 580050004548 active site 580050004549 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 580050004550 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 580050004551 Chain length determinant protein; Region: Wzz; cl15801 580050004552 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 580050004553 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 580050004554 Nucleotide binding site [chemical binding]; other site 580050004555 DTAP/Switch II; other site 580050004556 Switch I; other site 580050004557 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 580050004558 Transposase; Region: DDE_Tnp_ISL3; pfam01610 580050004559 homoserine kinase; Provisional; Region: PRK01212 580050004560 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 580050004561 homoserine dehydrogenase; Provisional; Region: PRK06349 580050004562 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 580050004563 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 580050004564 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 580050004565 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 580050004566 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 580050004567 catalytic residue [active] 580050004568 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 580050004569 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 580050004570 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 580050004571 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 580050004572 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 580050004573 active site 580050004574 HIGH motif; other site 580050004575 KMSK motif region; other site 580050004576 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 580050004577 tRNA binding surface [nucleotide binding]; other site 580050004578 anticodon binding site; other site 580050004579 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 580050004580 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 580050004581 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 580050004582 homotrimer interaction site [polypeptide binding]; other site 580050004583 putative active site [active] 580050004584 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 580050004585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050004586 dimer interface [polypeptide binding]; other site 580050004587 conserved gate region; other site 580050004588 putative PBP binding loops; other site 580050004589 ABC-ATPase subunit interface; other site 580050004590 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 580050004591 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 580050004592 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 580050004593 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 580050004594 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 580050004595 hypothetical protein; Provisional; Region: PRK03298 580050004596 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 580050004597 gamma subunit interface [polypeptide binding]; other site 580050004598 epsilon subunit interface [polypeptide binding]; other site 580050004599 LBP interface [polypeptide binding]; other site 580050004600 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 580050004601 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 580050004602 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 580050004603 alpha subunit interaction interface [polypeptide binding]; other site 580050004604 Walker A motif; other site 580050004605 ATP binding site [chemical binding]; other site 580050004606 Walker B motif; other site 580050004607 inhibitor binding site; inhibition site 580050004608 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 580050004609 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 580050004610 core domain interface [polypeptide binding]; other site 580050004611 delta subunit interface [polypeptide binding]; other site 580050004612 epsilon subunit interface [polypeptide binding]; other site 580050004613 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 580050004614 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 580050004615 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 580050004616 beta subunit interaction interface [polypeptide binding]; other site 580050004617 Walker A motif; other site 580050004618 ATP binding site [chemical binding]; other site 580050004619 Walker B motif; other site 580050004620 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 580050004621 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 580050004622 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 580050004623 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 580050004624 ATP synthase subunit C; Region: ATP-synt_C; cl00466 580050004625 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 580050004626 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 580050004627 homoserine O-succinyltransferase; Provisional; Region: PRK05368 580050004628 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 580050004629 proposed active site lysine [active] 580050004630 conserved cys residue [active] 580050004631 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050004632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050004633 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 580050004634 active site 580050004635 tetramer interface [polypeptide binding]; other site 580050004636 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 580050004637 Plasmid replication protein; Region: Rep_2; pfam01719 580050004638 Protein of unknown function DUF262; Region: DUF262; pfam03235 580050004639 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 580050004640 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 580050004641 active site 580050004642 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 580050004643 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 580050004644 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 580050004645 Int/Topo IB signature motif; other site 580050004646 formyl-coenzyme A transferase; Provisional; Region: PRK05398 580050004647 CoA-transferase family III; Region: CoA_transf_3; pfam02515 580050004648 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 580050004649 Cellulose or protein binding domain; Region: CBM_10; pfam02013 580050004650 Membrane transport protein; Region: Mem_trans; cl09117 580050004651 oxalyl-CoA decarboxylase; Region: oxalate_oxc; TIGR03254 580050004652 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 580050004653 TPP binding site [chemical binding]; other site 580050004654 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 580050004655 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 580050004656 TPP-binding site; other site 580050004657 dimer interface [polypeptide binding]; other site 580050004658 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 580050004659 dimer interface [polypeptide binding]; other site 580050004660 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 580050004661 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 580050004662 Cl- selectivity filter; other site 580050004663 Cl- binding residues [ion binding]; other site 580050004664 pore gating glutamate residue; other site 580050004665 dimer interface [polypeptide binding]; other site 580050004666 TQXA domain; Region: TQXA_dom; TIGR03934 580050004667 Cna protein B-type domain; Region: Cna_B; pfam05738 580050004668 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 580050004669 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 580050004670 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 580050004671 active site 580050004672 catalytic site [active] 580050004673 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 580050004674 dimer interface [polypeptide binding]; other site 580050004675 substrate binding site [chemical binding]; other site 580050004676 metal binding sites [ion binding]; metal-binding site 580050004677 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 580050004678 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 580050004679 DNA binding site [nucleotide binding] 580050004680 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 580050004681 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 580050004682 minor groove reading motif; other site 580050004683 helix-hairpin-helix signature motif; other site 580050004684 substrate binding pocket [chemical binding]; other site 580050004685 active site 580050004686 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 580050004687 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 580050004688 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 580050004689 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 580050004690 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 580050004691 active site 580050004692 HIGH motif; other site 580050004693 nucleotide binding site [chemical binding]; other site 580050004694 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 580050004695 active site 580050004696 KMSKS motif; other site 580050004697 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 580050004698 tRNA binding surface [nucleotide binding]; other site 580050004699 anticodon binding site; other site 580050004700 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 580050004701 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 580050004702 dimerization interface [polypeptide binding]; other site 580050004703 putative Zn2+ binding site [ion binding]; other site 580050004704 putative DNA binding site [nucleotide binding]; other site 580050004705 chorismate mutase; Provisional; Region: PRK09239 580050004706 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 580050004707 transcription termination factor Rho; Provisional; Region: PRK12608 580050004708 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 580050004709 RNA binding site [nucleotide binding]; other site 580050004710 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 580050004711 Walker A motif; other site 580050004712 ATP binding site [chemical binding]; other site 580050004713 Walker B motif; other site 580050004714 hypothetical protein; Provisional; Region: PRK07208 580050004715 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 580050004716 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 580050004717 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 580050004718 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 580050004719 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 580050004720 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 580050004721 GatB domain; Region: GatB_Yqey; pfam02637 580050004722 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 580050004723 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 580050004724 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 580050004725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050004726 ABC transporter signature motif; other site 580050004727 Walker B; other site 580050004728 D-loop; other site 580050004729 H-loop/switch region; other site 580050004730 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 580050004731 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 580050004732 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 580050004733 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 580050004734 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 580050004735 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 580050004736 Clp amino terminal domain; Region: Clp_N; pfam02861 580050004737 Clp amino terminal domain; Region: Clp_N; pfam02861 580050004738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050004739 Walker A motif; other site 580050004740 ATP binding site [chemical binding]; other site 580050004741 Walker B motif; other site 580050004742 arginine finger; other site 580050004743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 580050004744 Walker A motif; other site 580050004745 ATP binding site [chemical binding]; other site 580050004746 Walker B motif; other site 580050004747 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 580050004748 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 580050004749 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 580050004750 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 580050004751 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 580050004752 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 580050004753 metal ion-dependent adhesion site (MIDAS); other site 580050004754 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 580050004755 active site 580050004756 catalytic site [active] 580050004757 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 580050004758 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 580050004759 catalytic residue [active] 580050004760 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 580050004761 active site 580050004762 HIGH motif; other site 580050004763 nucleotide binding site [chemical binding]; other site 580050004764 active site 580050004765 KMSKS motif; other site 580050004766 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 580050004767 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 580050004768 amphipathic channel; other site 580050004769 Asn-Pro-Ala signature motifs; other site 580050004770 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 580050004771 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 580050004772 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 580050004773 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 580050004774 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 580050004775 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 580050004776 dimer interface [polypeptide binding]; other site 580050004777 ssDNA binding site [nucleotide binding]; other site 580050004778 tetramer (dimer of dimers) interface [polypeptide binding]; other site 580050004779 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 580050004780 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 580050004781 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 580050004782 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 580050004783 active site 580050004784 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 580050004785 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 580050004786 substrate binding site [chemical binding]; other site 580050004787 dimer interface [polypeptide binding]; other site 580050004788 ATP binding site [chemical binding]; other site 580050004789 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 580050004790 Major Facilitator Superfamily; Region: MFS_1; pfam07690 580050004791 putative substrate translocation pore; other site 580050004792 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 580050004793 active site 580050004794 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050004795 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050004796 DNA binding site [nucleotide binding] 580050004797 domain linker motif; other site 580050004798 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 580050004799 dimerization interface [polypeptide binding]; other site 580050004800 ligand binding site [chemical binding]; other site 580050004801 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 580050004802 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 580050004803 UDP-galactopyranose mutase; Region: GLF; pfam03275 580050004804 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 580050004805 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580050004806 active site 580050004807 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 580050004808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580050004809 active site 580050004810 Sulfatase; Region: Sulfatase; pfam00884 580050004811 Sulfatase; Region: Sulfatase; pfam00884 580050004812 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 580050004813 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580050004814 active site 580050004815 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 580050004816 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 580050004817 active site 580050004818 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 580050004819 active site 580050004820 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 580050004821 S-layer homology domain; Region: SLH; pfam00395 580050004822 S-layer homology domain; Region: SLH; pfam00395 580050004823 S-layer homology domain; Region: SLH; pfam00395 580050004824 MULE transposase domain; Region: MULE; pfam10551 580050004825 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 580050004826 Leucine rich repeat; Region: LRR_8; pfam13855 580050004827 S-layer homology domain; Region: SLH; pfam00395 580050004828 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 580050004829 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 580050004830 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 580050004831 Walker A/P-loop; other site 580050004832 ATP binding site [chemical binding]; other site 580050004833 Q-loop/lid; other site 580050004834 ABC transporter signature motif; other site 580050004835 Walker B; other site 580050004836 D-loop; other site 580050004837 H-loop/switch region; other site 580050004838 ABC-2 type transporter; Region: ABC2_membrane; cl17235 580050004839 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 580050004840 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 580050004841 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 580050004842 active site 580050004843 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 580050004844 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 580050004845 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 580050004846 FtsX-like permease family; Region: FtsX; pfam02687 580050004847 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 580050004848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050004849 ATP binding site [chemical binding]; other site 580050004850 Q-loop/lid; other site 580050004851 ABC transporter signature motif; other site 580050004852 Walker B; other site 580050004853 D-loop; other site 580050004854 H-loop/switch region; other site 580050004855 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 580050004856 Zn2+ binding site [ion binding]; other site 580050004857 Mg2+ binding site [ion binding]; other site 580050004858 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 580050004859 putative active site [active] 580050004860 putative dimer interface [polypeptide binding]; other site 580050004861 YL1 nuclear protein; Region: YL1; pfam05764 580050004862 K+ potassium transporter; Region: K_trans; pfam02705 580050004863 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 580050004864 active site 580050004865 Melibiase; Region: Melibiase; pfam02065 580050004866 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 580050004867 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 580050004868 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 580050004869 Walker A/P-loop; other site 580050004870 ATP binding site [chemical binding]; other site 580050004871 Q-loop/lid; other site 580050004872 ABC transporter signature motif; other site 580050004873 Walker B; other site 580050004874 D-loop; other site 580050004875 H-loop/switch region; other site 580050004876 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 580050004877 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 580050004878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 580050004879 Walker A/P-loop; other site 580050004880 ATP binding site [chemical binding]; other site 580050004881 Q-loop/lid; other site 580050004882 ABC transporter signature motif; other site 580050004883 Walker B; other site 580050004884 D-loop; other site 580050004885 H-loop/switch region; other site 580050004886 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 580050004887 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 580050004888 active site 580050004889 HIGH motif; other site 580050004890 KMSKS motif; other site 580050004891 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 580050004892 tRNA binding surface [nucleotide binding]; other site 580050004893 anticodon binding site; other site 580050004894 Predicted methyltransferases [General function prediction only]; Region: COG0313 580050004895 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 580050004896 putative SAM binding site [chemical binding]; other site 580050004897 putative homodimer interface [polypeptide binding]; other site 580050004898 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 580050004899 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 580050004900 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 580050004901 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 580050004902 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 580050004903 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 580050004904 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 580050004905 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 580050004906 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 580050004907 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 580050004908 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 580050004909 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 580050004910 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 580050004911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050004912 motif II; other site 580050004913 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 580050004914 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 580050004915 DNA binding residues [nucleotide binding] 580050004916 putative dimer interface [polypeptide binding]; other site 580050004917 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 580050004918 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 580050004919 HSP70 interaction site [polypeptide binding]; other site 580050004920 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 580050004921 substrate binding site [polypeptide binding]; other site 580050004922 dimer interface [polypeptide binding]; other site 580050004923 GrpE; Region: GrpE; pfam01025 580050004924 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 580050004925 dimer interface [polypeptide binding]; other site 580050004926 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 580050004927 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 580050004928 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 580050004929 nucleotide binding site [chemical binding]; other site 580050004930 NEF interaction site [polypeptide binding]; other site 580050004931 SBD interface [polypeptide binding]; other site 580050004932 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050004933 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050004934 DNA binding site [nucleotide binding] 580050004935 domain linker motif; other site 580050004936 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 580050004937 ligand binding site [chemical binding]; other site 580050004938 dimerization interface [polypeptide binding]; other site 580050004939 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 580050004940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050004941 motif II; other site 580050004942 pullulanase, type I; Region: pulA_typeI; TIGR02104 580050004943 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 580050004944 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 580050004945 Ca binding site [ion binding]; other site 580050004946 active site 580050004947 catalytic site [active] 580050004948 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 580050004949 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050004950 dimer interface [polypeptide binding]; other site 580050004951 conserved gate region; other site 580050004952 putative PBP binding loops; other site 580050004953 ABC-ATPase subunit interface; other site 580050004954 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 580050004955 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050004956 dimer interface [polypeptide binding]; other site 580050004957 conserved gate region; other site 580050004958 putative PBP binding loops; other site 580050004959 ABC-ATPase subunit interface; other site 580050004960 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 580050004961 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 580050004962 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 580050004963 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 580050004964 active site 580050004965 catalytic site [active] 580050004966 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 580050004967 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 580050004968 Protein of unknown function, DUF624; Region: DUF624; pfam04854 580050004969 Protein of unknown function, DUF624; Region: DUF624; cl02369 580050004970 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 580050004971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050004972 dimer interface [polypeptide binding]; other site 580050004973 conserved gate region; other site 580050004974 putative PBP binding loops; other site 580050004975 ABC-ATPase subunit interface; other site 580050004976 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 580050004977 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050004978 dimer interface [polypeptide binding]; other site 580050004979 conserved gate region; other site 580050004980 putative PBP binding loops; other site 580050004981 ABC-ATPase subunit interface; other site 580050004982 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050004983 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050004984 DNA binding site [nucleotide binding] 580050004985 domain linker motif; other site 580050004986 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 580050004987 ligand binding site [chemical binding]; other site 580050004988 dimerization interface [polypeptide binding]; other site 580050004989 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 580050004990 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 580050004991 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 580050004992 active site 580050004993 catalytic site [active] 580050004994 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 580050004995 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050004996 catalytic core [active] 580050004997 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 580050004998 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 580050004999 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 580050005000 dimer interface [polypeptide binding]; other site 580050005001 FMN binding site [chemical binding]; other site 580050005002 NADPH bind site [chemical binding]; other site 580050005003 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 580050005004 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 580050005005 active site 580050005006 catalytic triad [active] 580050005007 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 580050005008 RelB antitoxin; Region: RelB; cl01171 580050005009 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 580050005010 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 580050005011 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 580050005012 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 580050005013 Transcriptional regulators [Transcription]; Region: PurR; COG1609 580050005014 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 580050005015 DNA binding site [nucleotide binding] 580050005016 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 580050005017 dimerization interface [polypeptide binding]; other site 580050005018 ligand binding site [chemical binding]; other site 580050005019 NAD-dependent deacetylase; Provisional; Region: PRK00481 580050005020 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 580050005021 threonine dehydratase; Provisional; Region: PRK08198 580050005022 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 580050005023 tetramer interface [polypeptide binding]; other site 580050005024 pyridoxal 5'-phosphate binding site [chemical binding]; other site 580050005025 catalytic residue [active] 580050005026 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 580050005027 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 580050005028 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 580050005029 Ca binding site [ion binding]; other site 580050005030 active site 580050005031 catalytic site [active] 580050005032 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 580050005033 Probable galactinol--sucrose galactosyltransferase; Region: PLN02684 580050005034 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 580050005035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050005036 dimer interface [polypeptide binding]; other site 580050005037 conserved gate region; other site 580050005038 putative PBP binding loops; other site 580050005039 ABC-ATPase subunit interface; other site 580050005040 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 580050005041 dimer interface [polypeptide binding]; other site 580050005042 conserved gate region; other site 580050005043 putative PBP binding loops; other site 580050005044 ABC-ATPase subunit interface; other site 580050005045 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 580050005046 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 580050005047 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 580050005048 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 580050005049 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 580050005050 Melibiase; Region: Melibiase; pfam02065 580050005051 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 580050005052 nucleoside/Zn binding site; other site 580050005053 dimer interface [polypeptide binding]; other site 580050005054 catalytic motif [active] 580050005055 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 580050005056 Predicted esterase [General function prediction only]; Region: COG0400 580050005057 Serine hydrolase (FSH1); Region: FSH1; pfam03959 580050005058 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 580050005059 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 580050005060 trimer interface [polypeptide binding]; other site 580050005061 active site 580050005062 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 580050005063 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 580050005064 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 580050005065 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 580050005066 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 580050005067 motif II; other site 580050005068 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 580050005069 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 580050005070 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 580050005071 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 580050005072 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 580050005073 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 580050005074 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 580050005075 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 580050005076 Walker A/P-loop; other site 580050005077 ATP binding site [chemical binding]; other site 580050005078 Q-loop/lid; other site 580050005079 ABC transporter signature motif; other site 580050005080 Walker B; other site 580050005081 D-loop; other site 580050005082 H-loop/switch region; other site 580050005083 TOBE domain; Region: TOBE_2; pfam08402 580050005084 Ion channel; Region: Ion_trans_2; pfam07885 580050005085 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 580050005086 Catalytic domain of Protein Kinases; Region: PKc; cd00180 580050005087 active site 580050005088 ATP binding site [chemical binding]; other site 580050005089 substrate binding site [chemical binding]; other site 580050005090 activation loop (A-loop); other site 580050005091 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 580050005092 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 580050005093 Domain of unknown function (DUF348); Region: DUF348; pfam03990 580050005094 G5 domain; Region: G5; pfam07501 580050005095 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 580050005096 N-acetyl-D-glucosamine binding site [chemical binding]; other site 580050005097 catalytic residue [active] 580050005098 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 580050005099 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 580050005100 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 580050005101 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 580050005102 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 580050005103 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 580050005104 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 580050005105 active site 580050005106 NTP binding site [chemical binding]; other site 580050005107 metal binding triad [ion binding]; metal-binding site 580050005108 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 580050005109 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 580050005110 Zn2+ binding site [ion binding]; other site 580050005111 Mg2+ binding site [ion binding]; other site 580050005112 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 580050005113 active site 580050005114 Ap6A binding site [chemical binding]; other site 580050005115 nudix motif; other site 580050005116 metal binding site [ion binding]; metal-binding site 580050005117 integral membrane protein MviN; Region: mviN; TIGR01695 580050005118 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 580050005119 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 580050005120 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 580050005121 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 580050005122 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 580050005123 ParB-like nuclease domain; Region: ParB; smart00470 580050005124 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 580050005125 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 580050005126 P-loop; other site 580050005127 Magnesium ion binding site [ion binding]; other site 580050005128 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 580050005129 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 580050005130 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 580050005131 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 580050005132 G-X-X-G motif; other site 580050005133 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 580050005134 RxxxH motif; other site 580050005135 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 580050005136 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 580050005137 IncFII RepA protein family; Region: IncFII_repA; cl11495 580050005138 hypothetical protein; Provisional; Region: PRK14372 580050005139 Ribonuclease P; Region: Ribonuclease_P; pfam00825 580050005140 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399