-- dump date 20140619_002112 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1042403000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1042403000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403000003 Walker A motif; other site 1042403000004 ATP binding site [chemical binding]; other site 1042403000005 Walker B motif; other site 1042403000006 arginine finger; other site 1042403000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1042403000008 DnaA box-binding interface [nucleotide binding]; other site 1042403000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1042403000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1042403000011 putative DNA binding surface [nucleotide binding]; other site 1042403000012 dimer interface [polypeptide binding]; other site 1042403000013 beta-clamp/clamp loader binding surface; other site 1042403000014 beta-clamp/translesion DNA polymerase binding surface; other site 1042403000015 recombination protein F; Reviewed; Region: recF; PRK00064 1042403000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000017 Walker A/P-loop; other site 1042403000018 ATP binding site [chemical binding]; other site 1042403000019 Q-loop/lid; other site 1042403000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000021 ABC transporter signature motif; other site 1042403000022 Walker B; other site 1042403000023 D-loop; other site 1042403000024 H-loop/switch region; other site 1042403000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1042403000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1042403000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1042403000028 Mg2+ binding site [ion binding]; other site 1042403000029 G-X-G motif; other site 1042403000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1042403000031 anchoring element; other site 1042403000032 dimer interface [polypeptide binding]; other site 1042403000033 ATP binding site [chemical binding]; other site 1042403000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1042403000035 active site 1042403000036 putative metal-binding site [ion binding]; other site 1042403000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1042403000038 DNA gyrase subunit A; Validated; Region: PRK05560 1042403000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1042403000040 CAP-like domain; other site 1042403000041 active site 1042403000042 primary dimer interface [polypeptide binding]; other site 1042403000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1042403000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1042403000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1042403000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1042403000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1042403000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1042403000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1042403000050 VanZ like family; Region: VanZ; cl01971 1042403000051 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1042403000052 Haemolysin-III related; Region: HlyIII; pfam03006 1042403000053 glutamate dehydrogenase; Provisional; Region: PRK09414 1042403000054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1042403000055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1042403000056 NAD(P) binding site [chemical binding]; other site 1042403000057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403000059 putative substrate translocation pore; other site 1042403000060 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 1042403000061 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 1042403000062 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1042403000063 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1042403000064 Protein of unknown function DUF45; Region: DUF45; pfam01863 1042403000065 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1042403000066 MarR family; Region: MarR_2; pfam12802 1042403000067 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1042403000068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1042403000069 non-specific DNA interactions [nucleotide binding]; other site 1042403000070 DNA binding site [nucleotide binding] 1042403000071 sequence specific DNA binding site [nucleotide binding]; other site 1042403000072 putative cAMP binding site [chemical binding]; other site 1042403000073 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1042403000074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000075 Walker A/P-loop; other site 1042403000076 ATP binding site [chemical binding]; other site 1042403000077 Q-loop/lid; other site 1042403000078 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1042403000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000080 ABC transporter signature motif; other site 1042403000081 Walker B; other site 1042403000082 D-loop; other site 1042403000083 H-loop/switch region; other site 1042403000084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000085 Walker A/P-loop; other site 1042403000086 ATP binding site [chemical binding]; other site 1042403000087 Q-loop/lid; other site 1042403000088 ABC transporter signature motif; other site 1042403000089 Walker B; other site 1042403000090 D-loop; other site 1042403000091 H-loop/switch region; other site 1042403000092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1042403000093 S-adenosylmethionine binding site [chemical binding]; other site 1042403000094 Predicted flavoprotein [General function prediction only]; Region: COG0431 1042403000095 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1042403000096 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1042403000097 homodimer interface [polypeptide binding]; other site 1042403000098 chemical substrate binding site [chemical binding]; other site 1042403000099 oligomer interface [polypeptide binding]; other site 1042403000100 metal binding site [ion binding]; metal-binding site 1042403000101 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1042403000102 GIY-YIG motif/motif A; other site 1042403000103 active site 1042403000104 catalytic site [active] 1042403000105 Helix-turn-helix domain; Region: HTH_17; pfam12728 1042403000106 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1042403000107 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1042403000108 cofactor binding site; other site 1042403000109 DNA binding site [nucleotide binding] 1042403000110 substrate interaction site [chemical binding]; other site 1042403000111 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1042403000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1042403000113 PemK-like protein; Region: PemK; pfam02452 1042403000114 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1042403000115 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1042403000116 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1042403000117 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1042403000118 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1042403000119 active site 1042403000120 catalytic tetrad [active] 1042403000121 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1042403000122 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1042403000123 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1042403000124 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1042403000125 potential frameshift: common BLAST hit: gi|116630082|ref|YP_815254.1| aminoglycoside phosphotransferase 1042403000126 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1042403000127 Phosphotransferase enzyme family; Region: APH; pfam01636 1042403000128 substrate binding site [chemical binding]; other site 1042403000129 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 1042403000130 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1042403000131 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1042403000132 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1042403000133 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1042403000134 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1042403000135 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1042403000136 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1042403000137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403000138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403000139 putative substrate translocation pore; other site 1042403000140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1042403000141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1042403000142 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1042403000143 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1042403000144 dimerization interface [polypeptide binding]; other site 1042403000145 DPS ferroxidase diiron center [ion binding]; other site 1042403000146 ion pore; other site 1042403000147 Domain of unknown function DUF21; Region: DUF21; pfam01595 1042403000148 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1042403000149 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1042403000150 Transporter associated domain; Region: CorC_HlyC; smart01091 1042403000151 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 1042403000152 active site clefts [active] 1042403000153 zinc binding site [ion binding]; other site 1042403000154 dimer interface [polypeptide binding]; other site 1042403000155 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403000156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403000157 DNA binding site [nucleotide binding] 1042403000158 domain linker motif; other site 1042403000159 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1042403000160 ligand binding site [chemical binding]; other site 1042403000161 dimerization interface (open form) [polypeptide binding]; other site 1042403000162 dimerization interface (closed form) [polypeptide binding]; other site 1042403000163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000164 Walker A/P-loop; other site 1042403000165 ATP binding site [chemical binding]; other site 1042403000166 ABC transporter; Region: ABC_tran; pfam00005 1042403000167 Q-loop/lid; other site 1042403000168 ABC transporter signature motif; other site 1042403000169 Walker B; other site 1042403000170 D-loop; other site 1042403000171 H-loop/switch region; other site 1042403000172 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403000173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403000174 DNA binding site [nucleotide binding] 1042403000175 domain linker motif; other site 1042403000176 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1042403000177 ligand binding site [chemical binding]; other site 1042403000178 dimerization interface [polypeptide binding]; other site 1042403000179 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1042403000180 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1042403000181 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1042403000182 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1042403000183 putative N- and C-terminal domain interface [polypeptide binding]; other site 1042403000184 putative active site [active] 1042403000185 MgATP binding site [chemical binding]; other site 1042403000186 catalytic site [active] 1042403000187 metal binding site [ion binding]; metal-binding site 1042403000188 putative carbohydrate binding site [chemical binding]; other site 1042403000189 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1042403000190 intersubunit interface [polypeptide binding]; other site 1042403000191 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1042403000192 active site 1042403000193 Zn2+ binding site [ion binding]; other site 1042403000194 L-arabinose isomerase; Provisional; Region: PRK02929 1042403000195 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1042403000196 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1042403000197 trimer interface [polypeptide binding]; other site 1042403000198 substrate binding site [chemical binding]; other site 1042403000199 Mn binding site [ion binding]; other site 1042403000200 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1042403000201 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1042403000202 active site 1042403000203 catalytic tetrad [active] 1042403000204 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1042403000205 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1042403000206 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1042403000207 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1042403000208 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 1042403000209 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1042403000210 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1042403000211 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1042403000212 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1042403000213 active site 1042403000214 HIGH motif; other site 1042403000215 dimer interface [polypeptide binding]; other site 1042403000216 KMSKS motif; other site 1042403000217 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1042403000218 homodimer interface [polypeptide binding]; other site 1042403000219 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1042403000220 active site pocket [active] 1042403000221 Rhomboid family; Region: Rhomboid; pfam01694 1042403000222 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1042403000223 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1042403000224 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1042403000225 active site 1042403000226 catalytic site [active] 1042403000227 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1042403000228 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1042403000229 glutamine binding [chemical binding]; other site 1042403000230 catalytic triad [active] 1042403000231 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1042403000232 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1042403000233 active site 1042403000234 ATP binding site [chemical binding]; other site 1042403000235 substrate binding site [chemical binding]; other site 1042403000236 activation loop (A-loop); other site 1042403000237 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1042403000238 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1042403000239 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1042403000240 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1042403000241 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1042403000242 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1042403000243 active site 1042403000244 ATP binding site [chemical binding]; other site 1042403000245 substrate binding site [chemical binding]; other site 1042403000246 activation loop (A-loop); other site 1042403000247 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1042403000248 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1042403000249 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1042403000250 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1042403000251 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1042403000252 active site 1042403000253 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1042403000254 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1042403000255 phosphopeptide binding site; other site 1042403000256 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1042403000257 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1042403000258 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1042403000259 phosphopeptide binding site; other site 1042403000260 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1042403000261 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1042403000262 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1042403000263 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1042403000264 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1042403000265 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1042403000266 S-adenosylmethionine binding site [chemical binding]; other site 1042403000267 Predicted membrane protein [Function unknown]; Region: COG2261 1042403000268 ferredoxin-NADP+ reductase; Region: PLN02852 1042403000269 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1042403000270 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1042403000271 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1042403000272 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1042403000273 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1042403000274 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1042403000275 protein binding site [polypeptide binding]; other site 1042403000276 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1042403000277 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1042403000278 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1042403000279 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1042403000280 heat shock protein HtpX; Provisional; Region: PRK03072 1042403000281 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1042403000282 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1042403000283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403000284 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403000285 putative substrate translocation pore; other site 1042403000286 RelB antitoxin; Region: RelB; cl01171 1042403000287 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 1042403000288 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1042403000289 DNA binding site [nucleotide binding] 1042403000290 active site 1042403000291 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1042403000292 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1042403000293 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1042403000294 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1042403000295 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1042403000296 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1042403000297 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1042403000298 dimerization interface [polypeptide binding]; other site 1042403000299 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1042403000300 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1042403000301 active site 1042403000302 catalytic tetrad [active] 1042403000303 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 1042403000304 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1042403000305 FAD binding pocket [chemical binding]; other site 1042403000306 conserved FAD binding motif [chemical binding]; other site 1042403000307 phosphate binding motif [ion binding]; other site 1042403000308 beta-alpha-beta structure motif; other site 1042403000309 NAD binding pocket [chemical binding]; other site 1042403000310 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1042403000311 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1042403000312 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1042403000313 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1042403000314 NAD(P) binding site [chemical binding]; other site 1042403000315 putative active site [active] 1042403000316 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1042403000317 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1042403000318 catalytic Zn binding site [ion binding]; other site 1042403000319 NAD(P) binding site [chemical binding]; other site 1042403000320 structural Zn binding site [ion binding]; other site 1042403000321 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1042403000322 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1042403000323 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1042403000324 dimerization interface [polypeptide binding]; other site 1042403000325 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1042403000326 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1042403000327 NodB motif; other site 1042403000328 active site 1042403000329 catalytic site [active] 1042403000330 metal binding site [ion binding]; metal-binding site 1042403000331 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1042403000332 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1042403000333 active site 1042403000334 intersubunit interface [polypeptide binding]; other site 1042403000335 zinc binding site [ion binding]; other site 1042403000336 Na+ binding site [ion binding]; other site 1042403000337 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1042403000338 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1042403000339 GDP-binding site [chemical binding]; other site 1042403000340 ACT binding site; other site 1042403000341 IMP binding site; other site 1042403000342 CrcB-like protein; Region: CRCB; pfam02537 1042403000343 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1042403000344 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1042403000345 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1042403000346 TM-ABC transporter signature motif; other site 1042403000347 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1042403000348 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1042403000349 TM-ABC transporter signature motif; other site 1042403000350 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1042403000351 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1042403000352 Walker A/P-loop; other site 1042403000353 ATP binding site [chemical binding]; other site 1042403000354 Q-loop/lid; other site 1042403000355 ABC transporter signature motif; other site 1042403000356 Walker B; other site 1042403000357 D-loop; other site 1042403000358 H-loop/switch region; other site 1042403000359 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1042403000360 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1042403000361 ligand binding site [chemical binding]; other site 1042403000362 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403000363 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403000364 DNA binding site [nucleotide binding] 1042403000365 domain linker motif; other site 1042403000366 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1042403000367 sucrose phosphorylase; Provisional; Region: PRK13840 1042403000368 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1042403000369 active site 1042403000370 homodimer interface [polypeptide binding]; other site 1042403000371 catalytic site [active] 1042403000372 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 1042403000373 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403000374 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403000375 putative substrate translocation pore; other site 1042403000376 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1042403000377 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1042403000378 ligand binding site [chemical binding]; other site 1042403000379 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1042403000380 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1042403000381 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1042403000382 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1042403000383 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 1042403000384 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1042403000385 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1042403000386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1042403000387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403000388 metabolite-proton symporter; Region: 2A0106; TIGR00883 1042403000389 putative substrate translocation pore; other site 1042403000390 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1042403000391 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1042403000392 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1042403000393 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1042403000394 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1042403000395 active site 1042403000396 catalytic triad [active] 1042403000397 oxyanion hole [active] 1042403000398 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1042403000399 beta-galactosidase; Region: BGL; TIGR03356 1042403000400 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403000401 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403000402 DNA binding site [nucleotide binding] 1042403000403 domain linker motif; other site 1042403000404 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1042403000405 ligand binding site [chemical binding]; other site 1042403000406 dimerization interface [polypeptide binding]; other site 1042403000407 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1042403000408 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1042403000409 putative active cleft [active] 1042403000410 dimerization interface [polypeptide binding]; other site 1042403000411 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 1042403000412 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000413 Walker A/P-loop; other site 1042403000414 ATP binding site [chemical binding]; other site 1042403000415 Q-loop/lid; other site 1042403000416 ABC transporter signature motif; other site 1042403000417 Walker B; other site 1042403000418 D-loop; other site 1042403000419 H-loop/switch region; other site 1042403000420 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 1042403000421 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1042403000422 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1042403000423 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1042403000424 Walker A/P-loop; other site 1042403000425 ATP binding site [chemical binding]; other site 1042403000426 Q-loop/lid; other site 1042403000427 ABC transporter signature motif; other site 1042403000428 Walker B; other site 1042403000429 D-loop; other site 1042403000430 H-loop/switch region; other site 1042403000431 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1042403000432 FtsX-like permease family; Region: FtsX; pfam02687 1042403000433 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1042403000434 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1042403000435 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1042403000436 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1042403000437 FtsX-like permease family; Region: FtsX; pfam02687 1042403000438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000439 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1042403000440 ABC transporter signature motif; other site 1042403000441 Walker B; other site 1042403000442 D-loop; other site 1042403000443 H-loop/switch region; other site 1042403000444 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1042403000445 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1042403000446 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1042403000447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000448 Walker A/P-loop; other site 1042403000449 ATP binding site [chemical binding]; other site 1042403000450 Q-loop/lid; other site 1042403000451 ABC transporter signature motif; other site 1042403000452 Walker B; other site 1042403000453 D-loop; other site 1042403000454 H-loop/switch region; other site 1042403000455 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1042403000456 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1042403000457 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1042403000458 Walker A/P-loop; other site 1042403000459 ATP binding site [chemical binding]; other site 1042403000460 Q-loop/lid; other site 1042403000461 ABC transporter signature motif; other site 1042403000462 Walker B; other site 1042403000463 D-loop; other site 1042403000464 H-loop/switch region; other site 1042403000465 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1042403000466 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1042403000467 NodB motif; other site 1042403000468 active site 1042403000469 catalytic site [active] 1042403000470 metal binding site [ion binding]; metal-binding site 1042403000471 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1042403000472 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1042403000473 active site 1042403000474 substrate binding site [chemical binding]; other site 1042403000475 trimer interface [polypeptide binding]; other site 1042403000476 CoA binding site [chemical binding]; other site 1042403000477 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1042403000478 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 1042403000479 ligand binding site [chemical binding]; other site 1042403000480 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1042403000481 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1042403000482 Predicted membrane protein [Function unknown]; Region: COG1511 1042403000483 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1042403000484 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1042403000485 Predicted membrane protein [Function unknown]; Region: COG1511 1042403000486 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1042403000487 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1042403000488 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 1042403000489 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1042403000490 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1042403000491 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1042403000492 Walker A/P-loop; other site 1042403000493 ATP binding site [chemical binding]; other site 1042403000494 Q-loop/lid; other site 1042403000495 ABC transporter signature motif; other site 1042403000496 Walker B; other site 1042403000497 D-loop; other site 1042403000498 H-loop/switch region; other site 1042403000499 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403000500 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 1042403000501 Walker A/P-loop; other site 1042403000502 ATP binding site [chemical binding]; other site 1042403000503 Q-loop/lid; other site 1042403000504 ABC transporter signature motif; other site 1042403000505 Walker B; other site 1042403000506 D-loop; other site 1042403000507 H-loop/switch region; other site 1042403000508 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1042403000509 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1042403000510 active site 1042403000511 nucleophile elbow; other site 1042403000512 Peptidase family C69; Region: Peptidase_C69; pfam03577 1042403000513 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1042403000514 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1042403000515 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1042403000516 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1042403000517 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1042403000518 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1042403000519 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 1042403000520 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1042403000521 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1042403000522 metal binding triad; other site 1042403000523 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1042403000524 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1042403000525 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1042403000526 sequence-specific DNA binding site [nucleotide binding]; other site 1042403000527 salt bridge; other site 1042403000528 replicative DNA helicase; Region: DnaB; TIGR00665 1042403000529 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1042403000530 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1042403000531 Walker A motif; other site 1042403000532 ATP binding site [chemical binding]; other site 1042403000533 Walker B motif; other site 1042403000534 DNA binding loops [nucleotide binding] 1042403000535 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1042403000536 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1042403000537 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1042403000538 catalytic triad [active] 1042403000539 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1042403000540 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1042403000541 ABC1 family; Region: ABC1; cl17513 1042403000542 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1042403000543 active site 1042403000544 catalytic site [active] 1042403000545 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1042403000546 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1042403000547 active site 1042403000548 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1042403000549 active site 1042403000550 Ap6A binding site [chemical binding]; other site 1042403000551 nudix motif; other site 1042403000552 metal binding site [ion binding]; metal-binding site 1042403000553 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403000554 catalytic core [active] 1042403000555 polyphosphate kinase; Provisional; Region: PRK05443 1042403000556 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1042403000557 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1042403000558 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1042403000559 putative domain interface [polypeptide binding]; other site 1042403000560 putative active site [active] 1042403000561 catalytic site [active] 1042403000562 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1042403000563 putative domain interface [polypeptide binding]; other site 1042403000564 putative active site [active] 1042403000565 catalytic site [active] 1042403000566 Type II/IV secretion system protein; Region: T2SE; pfam00437 1042403000567 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1042403000568 Walker B motif; other site 1042403000569 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 1042403000570 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1042403000571 TadE-like protein; Region: TadE; pfam07811 1042403000572 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1042403000573 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403000574 Walker A motif; other site 1042403000575 ATP binding site [chemical binding]; other site 1042403000576 Walker B motif; other site 1042403000577 arginine finger; other site 1042403000578 recombination protein RecR; Reviewed; Region: recR; PRK00076 1042403000579 RecR protein; Region: RecR; pfam02132 1042403000580 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1042403000581 putative active site [active] 1042403000582 putative metal-binding site [ion binding]; other site 1042403000583 tetramer interface [polypeptide binding]; other site 1042403000584 aspartate kinase; Reviewed; Region: PRK06635 1042403000585 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1042403000586 putative nucleotide binding site [chemical binding]; other site 1042403000587 putative catalytic residues [active] 1042403000588 putative Mg ion binding site [ion binding]; other site 1042403000589 putative aspartate binding site [chemical binding]; other site 1042403000590 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1042403000591 putative allosteric regulatory site; other site 1042403000592 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 1042403000593 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1042403000594 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1042403000595 2-isopropylmalate synthase; Validated; Region: PRK03739 1042403000596 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1042403000597 active site 1042403000598 catalytic residues [active] 1042403000599 metal binding site [ion binding]; metal-binding site 1042403000600 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1042403000601 Transglycosylase; Region: Transgly; pfam00912 1042403000602 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1042403000603 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1042403000604 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1042403000605 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1042403000606 PAP2 superfamily; Region: PAP2; pfam01569 1042403000607 active site 1042403000608 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1042403000609 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1042403000610 active site 1042403000611 interdomain interaction site; other site 1042403000612 putative metal-binding site [ion binding]; other site 1042403000613 nucleotide binding site [chemical binding]; other site 1042403000614 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1042403000615 domain I; other site 1042403000616 phosphate binding site [ion binding]; other site 1042403000617 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1042403000618 domain II; other site 1042403000619 domain III; other site 1042403000620 nucleotide binding site [chemical binding]; other site 1042403000621 DNA binding groove [nucleotide binding] 1042403000622 catalytic site [active] 1042403000623 domain IV; other site 1042403000624 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1042403000625 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1042403000626 thymidylate kinase; Validated; Region: tmk; PRK00698 1042403000627 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1042403000628 TMP-binding site; other site 1042403000629 ATP-binding site [chemical binding]; other site 1042403000630 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1042403000631 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1042403000632 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1042403000633 substrate binding site [chemical binding]; other site 1042403000634 Peptidase family C69; Region: Peptidase_C69; pfam03577 1042403000635 Peptidase family C69; Region: Peptidase_C69; pfam03577 1042403000636 AAA domain; Region: AAA_14; pfam13173 1042403000637 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 1042403000638 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1042403000639 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 1042403000640 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1042403000641 putative active site [active] 1042403000642 Predicted membrane protein [Function unknown]; Region: COG2246 1042403000643 GtrA-like protein; Region: GtrA; pfam04138 1042403000644 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403000645 catalytic core [active] 1042403000646 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403000647 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403000648 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1042403000649 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1042403000650 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1042403000651 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1042403000652 active site 1042403000653 HIGH motif; other site 1042403000654 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1042403000655 active site 1042403000656 KMSKS motif; other site 1042403000657 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1042403000658 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1042403000659 putative active site [active] 1042403000660 putative metal binding site [ion binding]; other site 1042403000661 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1042403000662 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1042403000663 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1042403000664 Bacterial transcriptional regulator; Region: IclR; pfam01614 1042403000665 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1042403000666 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1042403000667 substrate binding site [chemical binding]; other site 1042403000668 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1042403000669 AsnC family; Region: AsnC_trans_reg; pfam01037 1042403000670 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1042403000671 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1042403000672 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1042403000673 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1042403000674 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1042403000675 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1042403000676 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1042403000677 CAAX protease self-immunity; Region: Abi; pfam02517 1042403000678 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1042403000679 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1042403000680 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1042403000681 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1042403000682 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1042403000683 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1042403000684 nucleophilic elbow; other site 1042403000685 catalytic triad; other site 1042403000686 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1042403000687 Predicted membrane protein [Function unknown]; Region: COG4905 1042403000688 aspartate aminotransferase; Provisional; Region: PRK06836 1042403000689 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403000690 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403000691 homodimer interface [polypeptide binding]; other site 1042403000692 catalytic residue [active] 1042403000693 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 1042403000694 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1042403000695 binding surface 1042403000696 TPR motif; other site 1042403000697 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1042403000698 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1042403000699 substrate binding site [chemical binding]; other site 1042403000700 ATP binding site [chemical binding]; other site 1042403000701 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1042403000702 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1042403000703 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1042403000704 ssDNA binding site; other site 1042403000705 generic binding surface II; other site 1042403000706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1042403000707 ATP binding site [chemical binding]; other site 1042403000708 putative Mg++ binding site [ion binding]; other site 1042403000709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403000710 nucleotide binding region [chemical binding]; other site 1042403000711 ATP-binding site [chemical binding]; other site 1042403000712 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1042403000713 metal ion-dependent adhesion site (MIDAS); other site 1042403000714 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1042403000715 T surface-antigen of pili; Region: FctA; pfam12892 1042403000716 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1042403000717 T surface-antigen of pili; Region: FctA; pfam12892 1042403000718 T surface-antigen of pili; Region: FctA; pfam12892 1042403000719 T surface-antigen of pili; Region: FctA; pfam12892 1042403000720 T surface-antigen of pili; Region: FctA; pfam12892 1042403000721 T surface-antigen of pili; Region: FctA; pfam12892 1042403000722 T surface-antigen of pili; Region: FctA; pfam12892 1042403000723 T surface-antigen of pili; Region: FctA; pfam12892 1042403000724 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1042403000725 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1042403000726 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1042403000727 S-adenosylmethionine binding site [chemical binding]; other site 1042403000728 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1042403000729 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1042403000730 RimM N-terminal domain; Region: RimM; pfam01782 1042403000731 PRC-barrel domain; Region: PRC; pfam05239 1042403000732 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1042403000733 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1042403000734 G-X-X-G motif; other site 1042403000735 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1042403000736 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1042403000737 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1042403000738 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1042403000739 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1042403000740 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1042403000741 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1042403000742 putative catalytic site [active] 1042403000743 putative metal binding site [ion binding]; other site 1042403000744 putative phosphate binding site [ion binding]; other site 1042403000745 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1042403000746 putative catalytic site [active] 1042403000747 putative phosphate binding site [ion binding]; other site 1042403000748 putative metal binding site [ion binding]; other site 1042403000749 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1042403000750 Cation efflux family; Region: Cation_efflux; pfam01545 1042403000751 signal recognition particle protein; Provisional; Region: PRK10867 1042403000752 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1042403000753 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1042403000754 P loop; other site 1042403000755 GTP binding site [chemical binding]; other site 1042403000756 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1042403000757 Protein involved in chromosome segregation, interacts with SMC proteins [Cell division and chromosome partitioning]; Region: HEC1; COG5185 1042403000758 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1042403000759 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1042403000760 active site 1042403000761 HIGH motif; other site 1042403000762 nucleotide binding site [chemical binding]; other site 1042403000763 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1042403000764 KMSKS motif; other site 1042403000765 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1042403000766 tRNA binding surface [nucleotide binding]; other site 1042403000767 anticodon binding site; other site 1042403000768 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1042403000769 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1042403000770 ABC transporter; Region: ABC_tran_2; pfam12848 1042403000771 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1042403000772 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1042403000773 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1042403000774 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1042403000775 catalytic triad [active] 1042403000776 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1042403000777 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1042403000778 putative valine binding site [chemical binding]; other site 1042403000779 dimer interface [polypeptide binding]; other site 1042403000780 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1042403000781 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1042403000782 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1042403000783 PYR/PP interface [polypeptide binding]; other site 1042403000784 dimer interface [polypeptide binding]; other site 1042403000785 TPP binding site [chemical binding]; other site 1042403000786 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1042403000787 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1042403000788 TPP-binding site [chemical binding]; other site 1042403000789 dimer interface [polypeptide binding]; other site 1042403000790 ribonuclease III; Reviewed; Region: rnc; PRK00102 1042403000791 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1042403000792 dimerization interface [polypeptide binding]; other site 1042403000793 active site 1042403000794 metal binding site [ion binding]; metal-binding site 1042403000795 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1042403000796 dsRNA binding site [nucleotide binding]; other site 1042403000797 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1042403000798 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1042403000799 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1042403000800 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1042403000801 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1042403000802 active site 1042403000803 (T/H)XGH motif; other site 1042403000804 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1042403000805 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1042403000806 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1042403000807 active site 1042403000808 catalytic tetrad [active] 1042403000809 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1042403000810 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1042403000811 active site 1042403000812 ribonuclease PH; Reviewed; Region: rph; PRK00173 1042403000813 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1042403000814 hexamer interface [polypeptide binding]; other site 1042403000815 active site 1042403000816 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1042403000817 active site 1042403000818 dimerization interface [polypeptide binding]; other site 1042403000819 FemAB family; Region: FemAB; pfam02388 1042403000820 Membrane transport protein; Region: Mem_trans; cl09117 1042403000821 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1042403000822 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1042403000823 Substrate binding site; other site 1042403000824 Cupin domain; Region: Cupin_2; cl17218 1042403000825 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1042403000826 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1042403000827 active site 1042403000828 dimer interface [polypeptide binding]; other site 1042403000829 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1042403000830 dimer interface [polypeptide binding]; other site 1042403000831 active site 1042403000832 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1042403000833 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1042403000834 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1042403000835 Catalytic site [active] 1042403000836 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1042403000837 RNA/DNA hybrid binding site [nucleotide binding]; other site 1042403000838 active site 1042403000839 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1042403000840 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1042403000841 Walker A/P-loop; other site 1042403000842 ATP binding site [chemical binding]; other site 1042403000843 Q-loop/lid; other site 1042403000844 ABC transporter signature motif; other site 1042403000845 Walker B; other site 1042403000846 D-loop; other site 1042403000847 H-loop/switch region; other site 1042403000848 FtsX-like permease family; Region: FtsX; pfam02687 1042403000849 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1042403000850 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1042403000851 metal binding site [ion binding]; metal-binding site 1042403000852 putative dimer interface [polypeptide binding]; other site 1042403000853 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1042403000854 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1042403000855 homodimer interface [polypeptide binding]; other site 1042403000856 oligonucleotide binding site [chemical binding]; other site 1042403000857 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1042403000858 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1042403000859 gamma-glutamyl kinase; Provisional; Region: PRK05429 1042403000860 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1042403000861 nucleotide binding site [chemical binding]; other site 1042403000862 homotetrameric interface [polypeptide binding]; other site 1042403000863 putative phosphate binding site [ion binding]; other site 1042403000864 putative allosteric binding site; other site 1042403000865 PUA domain; Region: PUA; pfam01472 1042403000866 aspartate aminotransferase; Provisional; Region: PRK05764 1042403000867 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403000868 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403000869 homodimer interface [polypeptide binding]; other site 1042403000870 catalytic residue [active] 1042403000871 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1042403000872 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1042403000873 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1042403000874 putative homodimer interface [polypeptide binding]; other site 1042403000875 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1042403000876 heterodimer interface [polypeptide binding]; other site 1042403000877 homodimer interface [polypeptide binding]; other site 1042403000878 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1042403000879 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1042403000880 23S rRNA interface [nucleotide binding]; other site 1042403000881 L7/L12 interface [polypeptide binding]; other site 1042403000882 putative thiostrepton binding site; other site 1042403000883 L25 interface [polypeptide binding]; other site 1042403000884 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1042403000885 mRNA/rRNA interface [nucleotide binding]; other site 1042403000886 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1042403000887 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1042403000888 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1042403000889 BioY family; Region: BioY; pfam02632 1042403000890 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 1042403000891 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1042403000892 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1042403000893 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1042403000894 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1042403000895 carboxyltransferase (CT) interaction site; other site 1042403000896 biotinylation site [posttranslational modification]; other site 1042403000897 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1042403000898 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1042403000899 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1042403000900 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1042403000901 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1042403000902 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1042403000903 FMN binding site [chemical binding]; other site 1042403000904 substrate binding site [chemical binding]; other site 1042403000905 putative catalytic residue [active] 1042403000906 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1042403000907 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1042403000908 active site 2 [active] 1042403000909 active site 1 [active] 1042403000910 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1042403000911 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1042403000912 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1042403000913 putative NAD(P) binding site [chemical binding]; other site 1042403000914 active site 1042403000915 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1042403000916 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1042403000917 active site 1042403000918 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1042403000919 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1042403000920 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1042403000921 NAD binding site [chemical binding]; other site 1042403000922 dimer interface [polypeptide binding]; other site 1042403000923 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1042403000924 substrate binding site [chemical binding]; other site 1042403000925 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1042403000926 16S/18S rRNA binding site [nucleotide binding]; other site 1042403000927 S13e-L30e interaction site [polypeptide binding]; other site 1042403000928 25S rRNA binding site [nucleotide binding]; other site 1042403000929 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1042403000930 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1042403000931 oligomer interface [polypeptide binding]; other site 1042403000932 RNA binding site [nucleotide binding]; other site 1042403000933 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1042403000934 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1042403000935 RNase E interface [polypeptide binding]; other site 1042403000936 trimer interface [polypeptide binding]; other site 1042403000937 active site 1042403000938 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1042403000939 putative nucleic acid binding region [nucleotide binding]; other site 1042403000940 G-X-X-G motif; other site 1042403000941 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1042403000942 RNA binding site [nucleotide binding]; other site 1042403000943 domain interface; other site 1042403000944 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1042403000945 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1042403000946 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1042403000947 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1042403000948 dimer interface [polypeptide binding]; other site 1042403000949 putative radical transfer pathway; other site 1042403000950 diiron center [ion binding]; other site 1042403000951 tyrosyl radical; other site 1042403000952 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1042403000953 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1042403000954 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1042403000955 active site 1042403000956 dimer interface [polypeptide binding]; other site 1042403000957 catalytic residues [active] 1042403000958 effector binding site; other site 1042403000959 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1042403000960 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1042403000961 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1042403000962 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1042403000963 active site 1042403000964 catalytic tetrad [active] 1042403000965 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1042403000966 Peptidase family U32; Region: Peptidase_U32; pfam01136 1042403000967 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1042403000968 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1042403000969 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1042403000970 substrate binding site; other site 1042403000971 dimer interface; other site 1042403000972 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1042403000973 putative substrate binding pocket [chemical binding]; other site 1042403000974 AC domain interface; other site 1042403000975 catalytic triad [active] 1042403000976 AB domain interface; other site 1042403000977 interchain disulfide; other site 1042403000978 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1042403000979 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1042403000980 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1042403000981 trimer interface [polypeptide binding]; other site 1042403000982 active site 1042403000983 G bulge; other site 1042403000984 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1042403000985 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1042403000986 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1042403000987 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 1042403000988 catalytic triad [active] 1042403000989 catalytic triad [active] 1042403000990 oxyanion hole [active] 1042403000991 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1042403000992 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1042403000993 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1042403000994 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1042403000995 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1042403000996 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1042403000997 dimer interface [polypeptide binding]; other site 1042403000998 phosphorylation site [posttranslational modification] 1042403000999 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1042403001000 ATP binding site [chemical binding]; other site 1042403001001 Mg2+ binding site [ion binding]; other site 1042403001002 G-X-G motif; other site 1042403001003 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1042403001004 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1042403001005 active site 1042403001006 phosphorylation site [posttranslational modification] 1042403001007 intermolecular recognition site; other site 1042403001008 dimerization interface [polypeptide binding]; other site 1042403001009 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1042403001010 DNA binding site [nucleotide binding] 1042403001011 PBP superfamily domain; Region: PBP_like_2; cl17296 1042403001012 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 1042403001013 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403001014 dimer interface [polypeptide binding]; other site 1042403001015 conserved gate region; other site 1042403001016 putative PBP binding loops; other site 1042403001017 ABC-ATPase subunit interface; other site 1042403001018 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1042403001019 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403001020 dimer interface [polypeptide binding]; other site 1042403001021 conserved gate region; other site 1042403001022 putative PBP binding loops; other site 1042403001023 ABC-ATPase subunit interface; other site 1042403001024 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1042403001025 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1042403001026 Walker A/P-loop; other site 1042403001027 ATP binding site [chemical binding]; other site 1042403001028 Q-loop/lid; other site 1042403001029 ABC transporter signature motif; other site 1042403001030 Walker B; other site 1042403001031 D-loop; other site 1042403001032 H-loop/switch region; other site 1042403001033 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1042403001034 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1042403001035 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1042403001036 intersubunit interface [polypeptide binding]; other site 1042403001037 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1042403001038 23S rRNA interface [nucleotide binding]; other site 1042403001039 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1042403001040 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1042403001041 peripheral dimer interface [polypeptide binding]; other site 1042403001042 core dimer interface [polypeptide binding]; other site 1042403001043 L10 interface [polypeptide binding]; other site 1042403001044 L11 interface [polypeptide binding]; other site 1042403001045 putative EF-Tu interaction site [polypeptide binding]; other site 1042403001046 putative EF-G interaction site [polypeptide binding]; other site 1042403001047 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1042403001048 phosphopeptide binding site; other site 1042403001049 Part of AAA domain; Region: AAA_19; pfam13245 1042403001050 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1042403001051 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1042403001052 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1042403001053 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1042403001054 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1042403001055 oligomerisation interface [polypeptide binding]; other site 1042403001056 mobile loop; other site 1042403001057 roof hairpin; other site 1042403001058 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1042403001059 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1042403001060 FAD binding domain; Region: FAD_binding_4; pfam01565 1042403001061 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1042403001062 amino acid transporter; Region: 2A0306; TIGR00909 1042403001063 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1042403001064 Ferredoxin [Energy production and conversion]; Region: COG1146 1042403001065 4Fe-4S binding domain; Region: Fer4; pfam00037 1042403001066 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1042403001067 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403001068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403001069 homodimer interface [polypeptide binding]; other site 1042403001070 catalytic residue [active] 1042403001071 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1042403001072 active site 1042403001073 DNA polymerase IV; Validated; Region: PRK02406 1042403001074 DNA binding site [nucleotide binding] 1042403001075 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 1042403001076 dimerization interface [polypeptide binding]; other site 1042403001077 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1042403001078 NAD binding site [chemical binding]; other site 1042403001079 ligand binding site [chemical binding]; other site 1042403001080 catalytic site [active] 1042403001081 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1042403001082 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1042403001083 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1042403001084 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1042403001085 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1042403001086 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1042403001087 23S rRNA interface [nucleotide binding]; other site 1042403001088 L3 interface [polypeptide binding]; other site 1042403001089 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1042403001090 pullulanase, type I; Region: pulA_typeI; TIGR02104 1042403001091 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1042403001092 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1042403001093 active site 1042403001094 catalytic site [active] 1042403001095 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1042403001096 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1042403001097 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1042403001098 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1042403001099 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1042403001100 putative catalytic cysteine [active] 1042403001101 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1042403001102 putative active site [active] 1042403001103 metal binding site [ion binding]; metal-binding site 1042403001104 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1042403001105 YwiC-like protein; Region: YwiC; pfam14256 1042403001106 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1042403001107 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1042403001108 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1042403001109 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1042403001110 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1042403001111 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1042403001112 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1042403001113 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1042403001114 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1042403001115 putative translocon binding site; other site 1042403001116 protein-rRNA interface [nucleotide binding]; other site 1042403001117 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1042403001118 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1042403001119 G-X-X-G motif; other site 1042403001120 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1042403001121 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1042403001122 23S rRNA interface [nucleotide binding]; other site 1042403001123 5S rRNA interface [nucleotide binding]; other site 1042403001124 putative antibiotic binding site [chemical binding]; other site 1042403001125 L25 interface [polypeptide binding]; other site 1042403001126 L27 interface [polypeptide binding]; other site 1042403001127 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1042403001128 23S rRNA interface [nucleotide binding]; other site 1042403001129 putative translocon interaction site; other site 1042403001130 signal recognition particle (SRP54) interaction site; other site 1042403001131 L23 interface [polypeptide binding]; other site 1042403001132 trigger factor interaction site; other site 1042403001133 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1042403001134 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1042403001135 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1042403001136 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1042403001137 RNA binding site [nucleotide binding]; other site 1042403001138 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1042403001139 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1042403001140 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1042403001141 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1042403001142 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1042403001143 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1042403001144 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1042403001145 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1042403001146 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1042403001147 23S rRNA interface [nucleotide binding]; other site 1042403001148 L21e interface [polypeptide binding]; other site 1042403001149 5S rRNA interface [nucleotide binding]; other site 1042403001150 L27 interface [polypeptide binding]; other site 1042403001151 L5 interface [polypeptide binding]; other site 1042403001152 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1042403001153 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1042403001154 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1042403001155 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1042403001156 23S rRNA binding site [nucleotide binding]; other site 1042403001157 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1042403001158 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1042403001159 SecY translocase; Region: SecY; pfam00344 1042403001160 adenylate kinase; Reviewed; Region: adk; PRK00279 1042403001161 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1042403001162 AMP-binding site [chemical binding]; other site 1042403001163 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1042403001164 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1042403001165 rRNA binding site [nucleotide binding]; other site 1042403001166 predicted 30S ribosome binding site; other site 1042403001167 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1042403001168 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1042403001169 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1042403001170 30S ribosomal protein S11; Validated; Region: PRK05309 1042403001171 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1042403001172 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1042403001173 alphaNTD homodimer interface [polypeptide binding]; other site 1042403001174 alphaNTD - beta interaction site [polypeptide binding]; other site 1042403001175 alphaNTD - beta' interaction site [polypeptide binding]; other site 1042403001176 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1042403001177 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1042403001178 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1042403001179 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1042403001180 dimerization interface 3.5A [polypeptide binding]; other site 1042403001181 active site 1042403001182 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1042403001183 NusA N-terminal domain; Region: NusA_N; pfam08529 1042403001184 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1042403001185 RNA binding site [nucleotide binding]; other site 1042403001186 homodimer interface [polypeptide binding]; other site 1042403001187 NusA-like KH domain; Region: KH_5; pfam13184 1042403001188 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1042403001189 G-X-X-G motif; other site 1042403001190 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1042403001191 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1042403001192 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 1042403001193 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1042403001194 G1 box; other site 1042403001195 putative GEF interaction site [polypeptide binding]; other site 1042403001196 GTP/Mg2+ binding site [chemical binding]; other site 1042403001197 Switch I region; other site 1042403001198 G2 box; other site 1042403001199 G3 box; other site 1042403001200 Switch II region; other site 1042403001201 G4 box; other site 1042403001202 G5 box; other site 1042403001203 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1042403001204 Translation-initiation factor 2; Region: IF-2; pfam11987 1042403001205 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1042403001206 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1042403001207 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1042403001208 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1042403001209 RNA binding site [nucleotide binding]; other site 1042403001210 active site 1042403001211 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1042403001212 FAD synthetase; Region: FAD_syn; pfam06574 1042403001213 active site 1042403001214 nucleotide binding site [chemical binding]; other site 1042403001215 HIGH motif; other site 1042403001216 KMSKS motif; other site 1042403001217 Riboflavin kinase; Region: Flavokinase; smart00904 1042403001218 DNA repair protein RadA; Provisional; Region: PRK11823 1042403001219 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1042403001220 Walker A motif; other site 1042403001221 ATP binding site [chemical binding]; other site 1042403001222 Walker B motif; other site 1042403001223 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1042403001224 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1042403001225 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1042403001226 active site 1042403001227 dimer interface [polypeptide binding]; other site 1042403001228 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1042403001229 RNA/DNA hybrid binding site [nucleotide binding]; other site 1042403001230 active site 1042403001231 seryl-tRNA synthetase; Provisional; Region: PRK05431 1042403001232 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1042403001233 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1042403001234 dimer interface [polypeptide binding]; other site 1042403001235 active site 1042403001236 motif 1; other site 1042403001237 motif 2; other site 1042403001238 motif 3; other site 1042403001239 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1042403001240 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1042403001241 phosphoglucomutase; Validated; Region: PRK07564 1042403001242 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1042403001243 active site 1042403001244 substrate binding site [chemical binding]; other site 1042403001245 metal binding site [ion binding]; metal-binding site 1042403001246 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1042403001247 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 1042403001248 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1042403001249 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1042403001250 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1042403001251 binding surface 1042403001252 TPR motif; other site 1042403001253 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1042403001254 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1042403001255 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1042403001256 active site 1042403001257 phosphorylation site [posttranslational modification] 1042403001258 intermolecular recognition site; other site 1042403001259 dimerization interface [polypeptide binding]; other site 1042403001260 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1042403001261 DNA binding residues [nucleotide binding] 1042403001262 dimerization interface [polypeptide binding]; other site 1042403001263 PspC domain; Region: PspC; pfam04024 1042403001264 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1042403001265 PspC domain; Region: PspC; pfam04024 1042403001266 IncA protein; Region: IncA; pfam04156 1042403001267 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 1042403001268 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1042403001269 homodimer interface [polypeptide binding]; other site 1042403001270 substrate-cofactor binding pocket; other site 1042403001271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403001272 catalytic residue [active] 1042403001273 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1042403001274 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1042403001275 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1042403001276 catalytic residue [active] 1042403001277 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1042403001278 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1042403001279 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1042403001280 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1042403001281 dimer interface [polypeptide binding]; other site 1042403001282 putative anticodon binding site; other site 1042403001283 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1042403001284 motif 1; other site 1042403001285 dimer interface [polypeptide binding]; other site 1042403001286 active site 1042403001287 motif 2; other site 1042403001288 motif 3; other site 1042403001289 Phospholipase B; Region: Phospholip_B; pfam04916 1042403001290 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1042403001291 trimer interface [polypeptide binding]; other site 1042403001292 active site 1042403001293 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 1042403001294 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1042403001295 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 1042403001296 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1042403001297 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1042403001298 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1042403001299 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403001300 catalytic core [active] 1042403001301 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403001302 myosin-cross-reactive antigen; Provisional; Region: PRK13977 1042403001303 potential frameshift: common BLAST hit: gi|148544876|ref|YP_001272246.1| alcohol dehydrogenase 1042403001304 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1042403001305 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1042403001306 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1042403001307 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1042403001308 NAD(P) binding site [chemical binding]; other site 1042403001309 mannose-6-phosphate isomerase; Region: PLN02288 1042403001310 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1042403001311 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1042403001312 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 1042403001313 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1042403001314 ATP binding site [chemical binding]; other site 1042403001315 Mg2+ binding site [ion binding]; other site 1042403001316 G-X-G motif; other site 1042403001317 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1042403001318 PhoU domain; Region: PhoU; pfam01895 1042403001319 PhoU domain; Region: PhoU; pfam01895 1042403001320 phosphoserine aminotransferase; Provisional; Region: PRK03080 1042403001321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1042403001322 catalytic residue [active] 1042403001323 CHAP domain; Region: CHAP; pfam05257 1042403001324 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1042403001325 NlpC/P60 family; Region: NLPC_P60; cl17555 1042403001326 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1042403001327 Ligand Binding Site [chemical binding]; other site 1042403001328 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1042403001329 Ligand Binding Site [chemical binding]; other site 1042403001330 OsmC-like protein; Region: OsmC; cl00767 1042403001331 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1042403001332 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1042403001333 dimerization interface [polypeptide binding]; other site 1042403001334 active site 1042403001335 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1042403001336 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1042403001337 folate binding site [chemical binding]; other site 1042403001338 NADP+ binding site [chemical binding]; other site 1042403001339 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1042403001340 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1042403001341 active site 1042403001342 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1042403001343 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1042403001344 NAD(P) binding site [chemical binding]; other site 1042403001345 active site 1042403001346 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1042403001347 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1042403001348 putative active site [active] 1042403001349 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 1042403001350 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1042403001351 serine/threonine protein kinase; Provisional; Region: PRK14879 1042403001352 AAA domain; Region: AAA_21; pfam13304 1042403001353 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1042403001354 putative active site [active] 1042403001355 putative metal-binding site [ion binding]; other site 1042403001356 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1042403001357 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1042403001358 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 1042403001359 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 1042403001360 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 1042403001361 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 1042403001362 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1042403001363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 1042403001364 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 1042403001365 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 1042403001366 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1042403001367 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1042403001368 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1042403001369 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1042403001370 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1042403001371 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1042403001372 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1042403001373 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1042403001374 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403001375 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403001376 DNA binding site [nucleotide binding] 1042403001377 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1042403001378 putative dimerization interface [polypeptide binding]; other site 1042403001379 putative ligand binding site [chemical binding]; other site 1042403001380 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1042403001381 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403001382 motif II; other site 1042403001383 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1042403001384 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1042403001385 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1042403001386 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1042403001387 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1042403001388 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1042403001389 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1042403001390 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1042403001391 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1042403001392 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403001393 dimer interface [polypeptide binding]; other site 1042403001394 conserved gate region; other site 1042403001395 putative PBP binding loops; other site 1042403001396 ABC-ATPase subunit interface; other site 1042403001397 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403001398 dimer interface [polypeptide binding]; other site 1042403001399 conserved gate region; other site 1042403001400 putative PBP binding loops; other site 1042403001401 ABC-ATPase subunit interface; other site 1042403001402 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403001403 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403001404 DNA binding site [nucleotide binding] 1042403001405 domain linker motif; other site 1042403001406 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1042403001407 ligand binding site [chemical binding]; other site 1042403001408 dimerization interface (open form) [polypeptide binding]; other site 1042403001409 dimerization interface (closed form) [polypeptide binding]; other site 1042403001410 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1042403001411 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1042403001412 active site 1042403001413 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1042403001414 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1042403001415 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1042403001416 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1042403001417 DXD motif; other site 1042403001418 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1042403001419 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1042403001420 Walker A/P-loop; other site 1042403001421 ATP binding site [chemical binding]; other site 1042403001422 Q-loop/lid; other site 1042403001423 ABC transporter signature motif; other site 1042403001424 Walker B; other site 1042403001425 D-loop; other site 1042403001426 H-loop/switch region; other site 1042403001427 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1042403001428 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1042403001429 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1042403001430 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1042403001431 Ligand Binding Site [chemical binding]; other site 1042403001432 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1042403001433 active site 1042403001434 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1042403001435 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403001436 Walker A motif; other site 1042403001437 ATP binding site [chemical binding]; other site 1042403001438 Walker B motif; other site 1042403001439 arginine finger; other site 1042403001440 Peptidase family M41; Region: Peptidase_M41; pfam01434 1042403001441 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1042403001442 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1042403001443 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1042403001444 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1042403001445 active site 1042403001446 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1042403001447 catalytic triad [active] 1042403001448 dimer interface [polypeptide binding]; other site 1042403001449 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1042403001450 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1042403001451 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1042403001452 ABC transporter; Region: ABC_tran_2; pfam12848 1042403001453 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1042403001454 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1042403001455 active site 1042403001456 catalytic residues [active] 1042403001457 metal binding site [ion binding]; metal-binding site 1042403001458 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1042403001459 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1042403001460 homodimer interface [polypeptide binding]; other site 1042403001461 substrate-cofactor binding pocket; other site 1042403001462 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403001463 catalytic residue [active] 1042403001464 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1042403001465 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1042403001466 xylose isomerase; Provisional; Region: PRK05474 1042403001467 xylose isomerase; Region: xylose_isom_A; TIGR02630 1042403001468 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1042403001469 active site 1042403001470 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403001471 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403001472 DNA binding site [nucleotide binding] 1042403001473 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 1042403001474 putative ligand binding site [chemical binding]; other site 1042403001475 putative dimerization interface [polypeptide binding]; other site 1042403001476 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1042403001477 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1042403001478 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1042403001479 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403001480 dimer interface [polypeptide binding]; other site 1042403001481 conserved gate region; other site 1042403001482 putative PBP binding loops; other site 1042403001483 ABC-ATPase subunit interface; other site 1042403001484 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1042403001485 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403001486 dimer interface [polypeptide binding]; other site 1042403001487 conserved gate region; other site 1042403001488 putative PBP binding loops; other site 1042403001489 ABC-ATPase subunit interface; other site 1042403001490 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1042403001491 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1042403001492 inhibitor binding site; inhibition site 1042403001493 active site 1042403001494 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1042403001495 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1042403001496 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 1042403001497 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1042403001498 substrate binding pocket [chemical binding]; other site 1042403001499 catalytic triad [active] 1042403001500 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1042403001501 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1042403001502 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 1042403001503 active site 1042403001504 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1042403001505 D-xylulose kinase; Region: XylB; TIGR01312 1042403001506 nucleotide binding site [chemical binding]; other site 1042403001507 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1042403001508 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1042403001509 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1042403001510 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1042403001511 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1042403001512 PCRF domain; Region: PCRF; pfam03462 1042403001513 RF-1 domain; Region: RF-1; pfam00472 1042403001514 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1042403001515 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1042403001516 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1042403001517 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1042403001518 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1042403001519 Mg++ binding site [ion binding]; other site 1042403001520 putative catalytic motif [active] 1042403001521 substrate binding site [chemical binding]; other site 1042403001522 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1042403001523 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1042403001524 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1042403001525 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1042403001526 active site 1042403001527 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1042403001528 catalytic site [active] 1042403001529 putative active site [active] 1042403001530 putative substrate binding site [chemical binding]; other site 1042403001531 dimer interface [polypeptide binding]; other site 1042403001532 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403001533 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1042403001534 active site 1042403001535 motif I; other site 1042403001536 motif II; other site 1042403001537 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1042403001538 AAA domain; Region: AAA_30; pfam13604 1042403001539 PIF1-like helicase; Region: PIF1; pfam05970 1042403001540 Protein of unknown function (DUF805); Region: DUF805; cl01224 1042403001541 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1042403001542 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1042403001543 dimer interface [polypeptide binding]; other site 1042403001544 motif 1; other site 1042403001545 active site 1042403001546 motif 2; other site 1042403001547 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1042403001548 putative deacylase active site [active] 1042403001549 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1042403001550 active site 1042403001551 motif 3; other site 1042403001552 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1042403001553 anticodon binding site; other site 1042403001554 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1042403001555 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1042403001556 dimer interface [polypeptide binding]; other site 1042403001557 ssDNA binding site [nucleotide binding]; other site 1042403001558 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1042403001559 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1042403001560 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1042403001561 active site 1042403001562 Zn binding site [ion binding]; other site 1042403001563 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1042403001564 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1042403001565 Citrate synthase; Region: Citrate_synt; pfam00285 1042403001566 oxalacetate binding site [chemical binding]; other site 1042403001567 citrylCoA binding site [chemical binding]; other site 1042403001568 coenzyme A binding site [chemical binding]; other site 1042403001569 catalytic triad [active] 1042403001570 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1042403001571 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1042403001572 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1042403001573 putative trimer interface [polypeptide binding]; other site 1042403001574 putative CoA binding site [chemical binding]; other site 1042403001575 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1042403001576 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1042403001577 RF-1 domain; Region: RF-1; pfam00472 1042403001578 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1042403001579 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403001580 Walker A/P-loop; other site 1042403001581 ATP binding site [chemical binding]; other site 1042403001582 Q-loop/lid; other site 1042403001583 ABC transporter signature motif; other site 1042403001584 Walker B; other site 1042403001585 D-loop; other site 1042403001586 H-loop/switch region; other site 1042403001587 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1042403001588 FtsX-like permease family; Region: FtsX; pfam02687 1042403001589 Surface antigen [General function prediction only]; Region: COG3942 1042403001590 CHAP domain; Region: CHAP; pfam05257 1042403001591 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1042403001592 SmpB-tmRNA interface; other site 1042403001593 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1042403001594 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1042403001595 substrate binding pocket [chemical binding]; other site 1042403001596 membrane-bound complex binding site; other site 1042403001597 hinge residues; other site 1042403001598 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1042403001599 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1042403001600 substrate binding pocket [chemical binding]; other site 1042403001601 membrane-bound complex binding site; other site 1042403001602 hinge residues; other site 1042403001603 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1042403001604 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403001605 dimer interface [polypeptide binding]; other site 1042403001606 conserved gate region; other site 1042403001607 putative PBP binding loops; other site 1042403001608 ABC-ATPase subunit interface; other site 1042403001609 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1042403001610 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1042403001611 Walker A/P-loop; other site 1042403001612 ATP binding site [chemical binding]; other site 1042403001613 Q-loop/lid; other site 1042403001614 ABC transporter signature motif; other site 1042403001615 Walker B; other site 1042403001616 D-loop; other site 1042403001617 H-loop/switch region; other site 1042403001618 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1042403001619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1042403001620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1042403001621 active site 1042403001622 phosphorylation site [posttranslational modification] 1042403001623 intermolecular recognition site; other site 1042403001624 dimerization interface [polypeptide binding]; other site 1042403001625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1042403001626 DNA binding residues [nucleotide binding] 1042403001627 dimerization interface [polypeptide binding]; other site 1042403001628 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1042403001629 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1042403001630 glutaminase active site [active] 1042403001631 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1042403001632 dimer interface [polypeptide binding]; other site 1042403001633 active site 1042403001634 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1042403001635 dimer interface [polypeptide binding]; other site 1042403001636 active site 1042403001637 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1042403001638 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1042403001639 active site 1042403001640 pantothenate kinase; Reviewed; Region: PRK13318 1042403001641 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1042403001642 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1042403001643 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1042403001644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403001645 dimer interface [polypeptide binding]; other site 1042403001646 conserved gate region; other site 1042403001647 putative PBP binding loops; other site 1042403001648 ABC-ATPase subunit interface; other site 1042403001649 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1042403001650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403001651 dimer interface [polypeptide binding]; other site 1042403001652 conserved gate region; other site 1042403001653 putative PBP binding loops; other site 1042403001654 ABC-ATPase subunit interface; other site 1042403001655 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1042403001656 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1042403001657 Walker A/P-loop; other site 1042403001658 ATP binding site [chemical binding]; other site 1042403001659 Q-loop/lid; other site 1042403001660 ABC transporter signature motif; other site 1042403001661 Walker B; other site 1042403001662 D-loop; other site 1042403001663 H-loop/switch region; other site 1042403001664 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1042403001665 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1042403001666 Walker A/P-loop; other site 1042403001667 ATP binding site [chemical binding]; other site 1042403001668 Q-loop/lid; other site 1042403001669 ABC transporter signature motif; other site 1042403001670 Walker B; other site 1042403001671 D-loop; other site 1042403001672 H-loop/switch region; other site 1042403001673 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1042403001674 cystathionine gamma-synthase; Provisional; Region: PRK07811 1042403001675 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1042403001676 homodimer interface [polypeptide binding]; other site 1042403001677 substrate-cofactor binding pocket; other site 1042403001678 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403001679 catalytic residue [active] 1042403001680 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1042403001681 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1042403001682 dimer interface [polypeptide binding]; other site 1042403001683 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403001684 catalytic residue [active] 1042403001685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1042403001686 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1042403001687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1042403001688 ATP binding site [chemical binding]; other site 1042403001689 ATP binding site [chemical binding]; other site 1042403001690 putative Mg++ binding site [ion binding]; other site 1042403001691 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403001692 nucleotide binding region [chemical binding]; other site 1042403001693 ATP-binding site [chemical binding]; other site 1042403001694 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1042403001695 HRDC domain; Region: HRDC; pfam00570 1042403001696 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1042403001697 putative active site [active] 1042403001698 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1042403001699 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1042403001700 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1042403001701 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 1042403001702 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1042403001703 active site 1042403001704 8-oxo-dGMP binding site [chemical binding]; other site 1042403001705 nudix motif; other site 1042403001706 metal binding site [ion binding]; metal-binding site 1042403001707 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1042403001708 PLD-like domain; Region: PLDc_2; pfam13091 1042403001709 putative homodimer interface [polypeptide binding]; other site 1042403001710 putative active site [active] 1042403001711 catalytic site [active] 1042403001712 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1042403001713 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1042403001714 ATP binding site [chemical binding]; other site 1042403001715 putative Mg++ binding site [ion binding]; other site 1042403001716 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403001717 nucleotide binding region [chemical binding]; other site 1042403001718 ATP-binding site [chemical binding]; other site 1042403001719 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1042403001720 Fic family protein [Function unknown]; Region: COG3177 1042403001721 Fic/DOC family; Region: Fic; cl00960 1042403001722 Protein of unknown function DUF262; Region: DUF262; pfam03235 1042403001723 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1042403001724 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1042403001725 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 1042403001726 Fic/DOC family; Region: Fic; cl00960 1042403001727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1042403001728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1042403001729 Coenzyme A binding pocket [chemical binding]; other site 1042403001730 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 1042403001731 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1042403001732 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1042403001733 putative active site [active] 1042403001734 metal binding site [ion binding]; metal-binding site 1042403001735 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1042403001736 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1042403001737 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1042403001738 alanine racemase; Reviewed; Region: alr; PRK00053 1042403001739 active site 1042403001740 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1042403001741 dimer interface [polypeptide binding]; other site 1042403001742 substrate binding site [chemical binding]; other site 1042403001743 catalytic residues [active] 1042403001744 DNA primase; Validated; Region: dnaG; PRK05667 1042403001745 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1042403001746 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1042403001747 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1042403001748 active site 1042403001749 metal binding site [ion binding]; metal-binding site 1042403001750 interdomain interaction site; other site 1042403001751 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1042403001752 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1042403001753 transmembrane helices; other site 1042403001754 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 1042403001755 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1042403001756 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1042403001757 TPP-binding site; other site 1042403001758 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1042403001759 PYR/PP interface [polypeptide binding]; other site 1042403001760 dimer interface [polypeptide binding]; other site 1042403001761 TPP binding site [chemical binding]; other site 1042403001762 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1042403001763 AIR carboxylase; Region: AIRC; pfam00731 1042403001764 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1042403001765 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1042403001766 NAD binding site [chemical binding]; other site 1042403001767 ATP-grasp domain; Region: ATP-grasp; pfam02222 1042403001768 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1042403001769 metal binding site 2 [ion binding]; metal-binding site 1042403001770 putative DNA binding helix; other site 1042403001771 metal binding site 1 [ion binding]; metal-binding site 1042403001772 dimer interface [polypeptide binding]; other site 1042403001773 structural Zn2+ binding site [ion binding]; other site 1042403001774 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1042403001775 Putative esterase; Region: Esterase; pfam00756 1042403001776 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1042403001777 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1042403001778 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1042403001779 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1042403001780 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1042403001781 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1042403001782 dimerization interface [polypeptide binding]; other site 1042403001783 putative ATP binding site [chemical binding]; other site 1042403001784 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1042403001785 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1042403001786 active site 1042403001787 tetramer interface [polypeptide binding]; other site 1042403001788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1042403001789 active site 1042403001790 DNA polymerase IV; Reviewed; Region: PRK03103 1042403001791 Y-family of DNA polymerases; Region: PolY; cl12025 1042403001792 active site 1042403001793 DNA binding site [nucleotide binding] 1042403001794 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 1042403001795 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 1042403001796 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1042403001797 Short C-terminal domain; Region: SHOCT; pfam09851 1042403001798 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1042403001799 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1042403001800 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1042403001801 dimerization interface [polypeptide binding]; other site 1042403001802 ATP binding site [chemical binding]; other site 1042403001803 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1042403001804 dimerization interface [polypeptide binding]; other site 1042403001805 ATP binding site [chemical binding]; other site 1042403001806 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1042403001807 conserved cys residue [active] 1042403001808 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1042403001809 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1042403001810 ATP binding site [chemical binding]; other site 1042403001811 active site 1042403001812 substrate binding site [chemical binding]; other site 1042403001813 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1042403001814 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1042403001815 ATP-grasp domain; Region: ATP-grasp; pfam02222 1042403001816 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1042403001817 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1042403001818 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1042403001819 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1042403001820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1042403001821 catalytic residue [active] 1042403001822 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1042403001823 S17 interaction site [polypeptide binding]; other site 1042403001824 S8 interaction site; other site 1042403001825 16S rRNA interaction site [nucleotide binding]; other site 1042403001826 streptomycin interaction site [chemical binding]; other site 1042403001827 23S rRNA interaction site [nucleotide binding]; other site 1042403001828 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1042403001829 30S ribosomal protein S7; Validated; Region: PRK05302 1042403001830 elongation factor G; Reviewed; Region: PRK00007 1042403001831 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1042403001832 G1 box; other site 1042403001833 putative GEF interaction site [polypeptide binding]; other site 1042403001834 GTP/Mg2+ binding site [chemical binding]; other site 1042403001835 Switch I region; other site 1042403001836 G2 box; other site 1042403001837 G3 box; other site 1042403001838 Switch II region; other site 1042403001839 G4 box; other site 1042403001840 G5 box; other site 1042403001841 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1042403001842 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1042403001843 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1042403001844 elongation factor Tu; Reviewed; Region: PRK00049 1042403001845 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1042403001846 G1 box; other site 1042403001847 GEF interaction site [polypeptide binding]; other site 1042403001848 GTP/Mg2+ binding site [chemical binding]; other site 1042403001849 Switch I region; other site 1042403001850 G2 box; other site 1042403001851 G3 box; other site 1042403001852 Switch II region; other site 1042403001853 G4 box; other site 1042403001854 G5 box; other site 1042403001855 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1042403001856 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1042403001857 Antibiotic Binding Site [chemical binding]; other site 1042403001858 Disulfide bond formation protein DsbB; Region: DsbB; cl00649 1042403001859 elongation factor P; Validated; Region: PRK00529 1042403001860 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1042403001861 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1042403001862 RNA binding site [nucleotide binding]; other site 1042403001863 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1042403001864 RNA binding site [nucleotide binding]; other site 1042403001865 transcription antitermination factor NusB; Region: nusB; TIGR01951 1042403001866 putative RNA binding site [nucleotide binding]; other site 1042403001867 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1042403001868 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1042403001869 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1042403001870 catalytic site [active] 1042403001871 subunit interface [polypeptide binding]; other site 1042403001872 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1042403001873 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1042403001874 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1042403001875 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1042403001876 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1042403001877 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1042403001878 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1042403001879 IMP binding site; other site 1042403001880 dimer interface [polypeptide binding]; other site 1042403001881 interdomain contacts; other site 1042403001882 partial ornithine binding site; other site 1042403001883 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1042403001884 active site 1042403001885 dimer interface [polypeptide binding]; other site 1042403001886 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1042403001887 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1042403001888 catalytic site [active] 1042403001889 G-X2-G-X-G-K; other site 1042403001890 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1042403001891 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1042403001892 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1042403001893 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1042403001894 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1042403001895 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1042403001896 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 1042403001897 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1042403001898 S-adenosylmethionine binding site [chemical binding]; other site 1042403001899 primosome assembly protein PriA; Provisional; Region: PRK14873 1042403001900 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1042403001901 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1042403001902 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1042403001903 putative active site [active] 1042403001904 substrate binding site [chemical binding]; other site 1042403001905 putative cosubstrate binding site; other site 1042403001906 catalytic site [active] 1042403001907 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1042403001908 substrate binding site [chemical binding]; other site 1042403001909 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1042403001910 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1042403001911 proteasome ATPase; Region: pup_AAA; TIGR03689 1042403001912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403001913 Walker A motif; other site 1042403001914 ATP binding site [chemical binding]; other site 1042403001915 Walker B motif; other site 1042403001916 arginine finger; other site 1042403001917 Pup-ligase protein; Region: Pup_ligase; cl15463 1042403001918 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1042403001919 active site 1042403001920 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 1042403001921 Pup-ligase protein; Region: Pup_ligase; cl15463 1042403001922 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1042403001923 IHF dimer interface [polypeptide binding]; other site 1042403001924 IHF - DNA interface [nucleotide binding]; other site 1042403001925 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1042403001926 adenylosuccinate lyase; Provisional; Region: PRK09285 1042403001927 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1042403001928 tetramer interface [polypeptide binding]; other site 1042403001929 active site 1042403001930 Secretory lipase; Region: LIP; pfam03583 1042403001931 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1042403001932 metal ion-dependent adhesion site (MIDAS); other site 1042403001933 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1042403001934 metal ion-dependent adhesion site (MIDAS); other site 1042403001935 Protein of unknown function DUF58; Region: DUF58; pfam01882 1042403001936 MoxR-like ATPases [General function prediction only]; Region: COG0714 1042403001937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1042403001938 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1042403001939 active site 1042403001940 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1042403001941 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1042403001942 DNA-binding site [nucleotide binding]; DNA binding site 1042403001943 RNA-binding motif; other site 1042403001944 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1042403001945 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1042403001946 ring oligomerisation interface [polypeptide binding]; other site 1042403001947 ATP/Mg binding site [chemical binding]; other site 1042403001948 stacking interactions; other site 1042403001949 hinge regions; other site 1042403001950 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1042403001951 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1042403001952 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1042403001953 active site 1042403001954 phosphorylation site [posttranslational modification] 1042403001955 intermolecular recognition site; other site 1042403001956 dimerization interface [polypeptide binding]; other site 1042403001957 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1042403001958 DNA binding site [nucleotide binding] 1042403001959 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1042403001960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1042403001961 dimerization interface [polypeptide binding]; other site 1042403001962 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1042403001963 dimer interface [polypeptide binding]; other site 1042403001964 phosphorylation site [posttranslational modification] 1042403001965 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1042403001966 ATP binding site [chemical binding]; other site 1042403001967 Mg2+ binding site [ion binding]; other site 1042403001968 G-X-G motif; other site 1042403001969 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1042403001970 DNA-binding site [nucleotide binding]; DNA binding site 1042403001971 RNA-binding motif; other site 1042403001972 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1042403001973 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1042403001974 Ligand Binding Site [chemical binding]; other site 1042403001975 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1042403001976 Ligand Binding Site [chemical binding]; other site 1042403001977 Clp protease ATP binding subunit; Region: clpC; CHL00095 1042403001978 Clp amino terminal domain; Region: Clp_N; pfam02861 1042403001979 Clp amino terminal domain; Region: Clp_N; pfam02861 1042403001980 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403001981 Walker A motif; other site 1042403001982 ATP binding site [chemical binding]; other site 1042403001983 Walker B motif; other site 1042403001984 arginine finger; other site 1042403001985 UvrB/uvrC motif; Region: UVR; pfam02151 1042403001986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403001987 Walker A motif; other site 1042403001988 ATP binding site [chemical binding]; other site 1042403001989 Walker B motif; other site 1042403001990 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1042403001991 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1042403001992 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1042403001993 dimer interface [polypeptide binding]; other site 1042403001994 anticodon binding site; other site 1042403001995 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1042403001996 motif 1; other site 1042403001997 dimer interface [polypeptide binding]; other site 1042403001998 active site 1042403001999 motif 2; other site 1042403002000 GAD domain; Region: GAD; pfam02938 1042403002001 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1042403002002 active site 1042403002003 motif 3; other site 1042403002004 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1042403002005 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1042403002006 dimer interface [polypeptide binding]; other site 1042403002007 motif 1; other site 1042403002008 active site 1042403002009 motif 2; other site 1042403002010 motif 3; other site 1042403002011 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1042403002012 anticodon binding site; other site 1042403002013 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1042403002014 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1042403002015 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1042403002016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1042403002017 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1042403002018 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1042403002019 Walker A/P-loop; other site 1042403002020 ATP binding site [chemical binding]; other site 1042403002021 Q-loop/lid; other site 1042403002022 ABC transporter signature motif; other site 1042403002023 Walker B; other site 1042403002024 D-loop; other site 1042403002025 H-loop/switch region; other site 1042403002026 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1042403002027 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1042403002028 substrate binding pocket [chemical binding]; other site 1042403002029 membrane-bound complex binding site; other site 1042403002030 hinge residues; other site 1042403002031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403002032 dimer interface [polypeptide binding]; other site 1042403002033 conserved gate region; other site 1042403002034 ABC-ATPase subunit interface; other site 1042403002035 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1042403002036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403002037 dimer interface [polypeptide binding]; other site 1042403002038 conserved gate region; other site 1042403002039 putative PBP binding loops; other site 1042403002040 ABC-ATPase subunit interface; other site 1042403002041 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1042403002042 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1042403002043 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1042403002044 ATP binding site [chemical binding]; other site 1042403002045 putative Mg++ binding site [ion binding]; other site 1042403002046 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403002047 nucleotide binding region [chemical binding]; other site 1042403002048 ATP-binding site [chemical binding]; other site 1042403002049 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1042403002050 recombination factor protein RarA; Reviewed; Region: PRK13342 1042403002051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403002052 Walker A motif; other site 1042403002053 ATP binding site [chemical binding]; other site 1042403002054 Walker B motif; other site 1042403002055 arginine finger; other site 1042403002056 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1042403002057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403002058 putative substrate translocation pore; other site 1042403002059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403002060 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1042403002061 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1042403002062 acyl-activating enzyme (AAE) consensus motif; other site 1042403002063 putative AMP binding site [chemical binding]; other site 1042403002064 putative active site [active] 1042403002065 putative CoA binding site [chemical binding]; other site 1042403002066 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1042403002067 MULE transposase domain; Region: MULE; pfam10551 1042403002068 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1042403002069 Coenzyme A binding pocket [chemical binding]; other site 1042403002070 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1042403002071 hypothetical protein; Provisional; Region: PRK11770 1042403002072 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1042403002073 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1042403002074 Putative transcription activator [Transcription]; Region: TenA; COG0819 1042403002075 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 1042403002076 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1042403002077 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1042403002078 active site 1042403002079 catalytic tetrad [active] 1042403002080 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1042403002081 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1042403002082 Walker A/P-loop; other site 1042403002083 ATP binding site [chemical binding]; other site 1042403002084 Q-loop/lid; other site 1042403002085 ABC transporter signature motif; other site 1042403002086 Walker B; other site 1042403002087 D-loop; other site 1042403002088 H-loop/switch region; other site 1042403002089 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1042403002090 Walker A/P-loop; other site 1042403002091 ATP binding site [chemical binding]; other site 1042403002092 Q-loop/lid; other site 1042403002093 ABC transporter signature motif; other site 1042403002094 Walker B; other site 1042403002095 D-loop; other site 1042403002096 H-loop/switch region; other site 1042403002097 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1042403002098 KinB-signalling pathway activation in sporulation; Region: KbaA; pfam14089 1042403002099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403002100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403002101 homodimer interface [polypeptide binding]; other site 1042403002102 catalytic residue [active] 1042403002103 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1042403002104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403002105 Walker A/P-loop; other site 1042403002106 ATP binding site [chemical binding]; other site 1042403002107 Q-loop/lid; other site 1042403002108 ABC transporter signature motif; other site 1042403002109 Walker B; other site 1042403002110 D-loop; other site 1042403002111 H-loop/switch region; other site 1042403002112 Ligase N family; Region: LIGANc; smart00532 1042403002113 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1042403002114 nucleotide binding pocket [chemical binding]; other site 1042403002115 K-X-D-G motif; other site 1042403002116 catalytic site [active] 1042403002117 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1042403002118 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1042403002119 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1042403002120 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1042403002121 Dimer interface [polypeptide binding]; other site 1042403002122 Domain of unknown function DUF59; Region: DUF59; cl00941 1042403002123 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1042403002124 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1042403002125 glutamine synthetase, type I; Region: GlnA; TIGR00653 1042403002126 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1042403002127 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1042403002128 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1042403002129 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1042403002130 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1042403002131 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1042403002132 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1042403002133 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1042403002134 hypothetical protein; Provisional; Region: PRK07907 1042403002135 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1042403002136 active site 1042403002137 metal binding site [ion binding]; metal-binding site 1042403002138 dimer interface [polypeptide binding]; other site 1042403002139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1042403002140 Histidine kinase; Region: HisKA_3; pfam07730 1042403002141 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1042403002142 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403002143 Q-loop/lid; other site 1042403002144 ABC transporter signature motif; other site 1042403002145 Walker B; other site 1042403002146 D-loop; other site 1042403002147 H-loop/switch region; other site 1042403002148 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1042403002149 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1042403002150 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1042403002151 Walker A/P-loop; other site 1042403002152 ATP binding site [chemical binding]; other site 1042403002153 Q-loop/lid; other site 1042403002154 ABC transporter signature motif; other site 1042403002155 Walker B; other site 1042403002156 D-loop; other site 1042403002157 H-loop/switch region; other site 1042403002158 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1042403002159 Walker A/P-loop; other site 1042403002160 ATP binding site [chemical binding]; other site 1042403002161 Q-loop/lid; other site 1042403002162 ABC transporter signature motif; other site 1042403002163 Walker B; other site 1042403002164 D-loop; other site 1042403002165 H-loop/switch region; other site 1042403002166 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1042403002167 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1042403002168 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1042403002169 Walker A/P-loop; other site 1042403002170 ATP binding site [chemical binding]; other site 1042403002171 Q-loop/lid; other site 1042403002172 ABC transporter signature motif; other site 1042403002173 Walker B; other site 1042403002174 D-loop; other site 1042403002175 H-loop/switch region; other site 1042403002176 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1042403002177 FtsX-like permease family; Region: FtsX; pfam02687 1042403002178 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1042403002179 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1042403002180 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1042403002181 dimer interface [polypeptide binding]; other site 1042403002182 motif 1; other site 1042403002183 active site 1042403002184 motif 2; other site 1042403002185 motif 3; other site 1042403002186 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1042403002187 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1042403002188 putative tRNA-binding site [nucleotide binding]; other site 1042403002189 B3/4 domain; Region: B3_4; pfam03483 1042403002190 tRNA synthetase B5 domain; Region: B5; smart00874 1042403002191 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1042403002192 dimer interface [polypeptide binding]; other site 1042403002193 motif 1; other site 1042403002194 motif 3; other site 1042403002195 motif 2; other site 1042403002196 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1042403002197 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1042403002198 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1042403002199 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1042403002200 heterotetramer interface [polypeptide binding]; other site 1042403002201 active site pocket [active] 1042403002202 cleavage site 1042403002203 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1042403002204 feedback inhibition sensing region; other site 1042403002205 homohexameric interface [polypeptide binding]; other site 1042403002206 nucleotide binding site [chemical binding]; other site 1042403002207 N-acetyl-L-glutamate binding site [chemical binding]; other site 1042403002208 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1042403002209 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1042403002210 inhibitor-cofactor binding pocket; inhibition site 1042403002211 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403002212 catalytic residue [active] 1042403002213 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1042403002214 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1042403002215 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1042403002216 arginine repressor; Provisional; Region: PRK03341 1042403002217 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1042403002218 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1042403002219 argininosuccinate synthase; Provisional; Region: PRK13820 1042403002220 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1042403002221 ANP binding site [chemical binding]; other site 1042403002222 Substrate Binding Site II [chemical binding]; other site 1042403002223 Substrate Binding Site I [chemical binding]; other site 1042403002224 argininosuccinate lyase; Provisional; Region: PRK00855 1042403002225 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1042403002226 active sites [active] 1042403002227 tetramer interface [polypeptide binding]; other site 1042403002228 acetoin reductases; Region: 23BDH; TIGR02415 1042403002229 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1042403002230 NAD(P) binding site [chemical binding]; other site 1042403002231 active site 1042403002232 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1042403002233 Zn2+ binding site [ion binding]; other site 1042403002234 Mg2+ binding site [ion binding]; other site 1042403002235 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1042403002236 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1042403002237 active site 1042403002238 HIGH motif; other site 1042403002239 dimer interface [polypeptide binding]; other site 1042403002240 KMSKS motif; other site 1042403002241 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1042403002242 RNA binding surface [nucleotide binding]; other site 1042403002243 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1042403002244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403002245 active site 1042403002246 motif I; other site 1042403002247 motif II; other site 1042403002248 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403002249 motif II; other site 1042403002250 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1042403002251 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1042403002252 RNA binding surface [nucleotide binding]; other site 1042403002253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1042403002254 S-adenosylmethionine binding site [chemical binding]; other site 1042403002255 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1042403002256 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1042403002257 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1042403002258 TrkA-N domain; Region: TrkA_N; pfam02254 1042403002259 TrkA-C domain; Region: TrkA_C; pfam02080 1042403002260 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1042403002261 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 1042403002262 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1042403002263 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1042403002264 Walker A/P-loop; other site 1042403002265 ATP binding site [chemical binding]; other site 1042403002266 Q-loop/lid; other site 1042403002267 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1042403002268 ABC transporter signature motif; other site 1042403002269 Walker B; other site 1042403002270 D-loop; other site 1042403002271 H-loop/switch region; other site 1042403002272 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1042403002273 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1042403002274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403002275 motif II; other site 1042403002276 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1042403002277 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1042403002278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403002279 catalytic residue [active] 1042403002280 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1042403002281 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1042403002282 putative catalytic cysteine [active] 1042403002283 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1042403002284 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1042403002285 active site 1042403002286 (T/H)XGH motif; other site 1042403002287 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1042403002288 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1042403002289 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1042403002290 active site 1042403002291 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1042403002292 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1042403002293 Substrate binding site; other site 1042403002294 Mg++ binding site; other site 1042403002295 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1042403002296 active site 1042403002297 substrate binding site [chemical binding]; other site 1042403002298 CoA binding site [chemical binding]; other site 1042403002299 Oligomerisation domain; Region: Oligomerisation; pfam02410 1042403002300 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403002301 catalytic core [active] 1042403002302 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1042403002303 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403002304 catalytic core [active] 1042403002305 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1042403002306 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1042403002307 Cl binding site [ion binding]; other site 1042403002308 oligomer interface [polypeptide binding]; other site 1042403002309 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1042403002310 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1042403002311 substrate binding pocket [chemical binding]; other site 1042403002312 membrane-bound complex binding site; other site 1042403002313 hinge residues; other site 1042403002314 aminoacyl-tRNA ligase; Region: PLN02563 1042403002315 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1042403002316 active site 1042403002317 HIGH motif; other site 1042403002318 nucleotide binding site [chemical binding]; other site 1042403002319 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1042403002320 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1042403002321 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1042403002322 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1042403002323 active site 1042403002324 KMSKS motif; other site 1042403002325 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1042403002326 tRNA binding surface [nucleotide binding]; other site 1042403002327 Helix-hairpin-helix motif; Region: HHH; pfam00633 1042403002328 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1042403002329 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1042403002330 Competence protein; Region: Competence; pfam03772 1042403002331 hypothetical protein; Reviewed; Region: PRK07914 1042403002332 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1042403002333 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1042403002334 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1042403002335 Glycoprotease family; Region: Peptidase_M22; pfam00814 1042403002336 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1042403002337 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1042403002338 Coenzyme A binding pocket [chemical binding]; other site 1042403002339 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1042403002340 UGMP family protein; Validated; Region: PRK09604 1042403002341 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1042403002342 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1042403002343 isocitrate dehydrogenase; Validated; Region: PRK08299 1042403002344 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1042403002345 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1042403002346 phosphate binding site [ion binding]; other site 1042403002347 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1042403002348 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1042403002349 acyl-activating enzyme (AAE) consensus motif; other site 1042403002350 putative AMP binding site [chemical binding]; other site 1042403002351 putative active site [active] 1042403002352 putative CoA binding site [chemical binding]; other site 1042403002353 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1042403002354 active site 1042403002355 catalytic residues [active] 1042403002356 metal binding site [ion binding]; metal-binding site 1042403002357 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1042403002358 rRNA interaction site [nucleotide binding]; other site 1042403002359 S8 interaction site; other site 1042403002360 putative laminin-1 binding site; other site 1042403002361 elongation factor Ts; Provisional; Region: tsf; PRK09377 1042403002362 UBA/TS-N domain; Region: UBA; pfam00627 1042403002363 Elongation factor TS; Region: EF_TS; pfam00889 1042403002364 Elongation factor TS; Region: EF_TS; pfam00889 1042403002365 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1042403002366 putative nucleotide binding site [chemical binding]; other site 1042403002367 uridine monophosphate binding site [chemical binding]; other site 1042403002368 homohexameric interface [polypeptide binding]; other site 1042403002369 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1042403002370 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1042403002371 hinge region; other site 1042403002372 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1042403002373 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1042403002374 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1042403002375 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1042403002376 FeS/SAM binding site; other site 1042403002377 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1042403002378 WHG domain; Region: WHG; pfam13305 1042403002379 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1042403002380 Walker A/P-loop; other site 1042403002381 ATP binding site [chemical binding]; other site 1042403002382 ABC transporter; Region: ABC_tran; pfam00005 1042403002383 Q-loop/lid; other site 1042403002384 ABC transporter signature motif; other site 1042403002385 Walker B; other site 1042403002386 D-loop; other site 1042403002387 H-loop/switch region; other site 1042403002388 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1042403002389 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1042403002390 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1042403002391 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1042403002392 substrate binding site [chemical binding]; other site 1042403002393 glutamase interaction surface [polypeptide binding]; other site 1042403002394 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1042403002395 anthranilate synthase component I; Provisional; Region: PRK13571 1042403002396 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1042403002397 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1042403002398 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1042403002399 putative uracil binding site [chemical binding]; other site 1042403002400 putative active site [active] 1042403002401 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 1042403002402 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1042403002403 active site 1042403002404 ribulose/triose binding site [chemical binding]; other site 1042403002405 phosphate binding site [ion binding]; other site 1042403002406 substrate (anthranilate) binding pocket [chemical binding]; other site 1042403002407 product (indole) binding pocket [chemical binding]; other site 1042403002408 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1042403002409 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403002410 catalytic residue [active] 1042403002411 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1042403002412 substrate binding site [chemical binding]; other site 1042403002413 active site 1042403002414 catalytic residues [active] 1042403002415 heterodimer interface [polypeptide binding]; other site 1042403002416 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1042403002417 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1042403002418 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1042403002419 substrate binding site [chemical binding]; other site 1042403002420 hexamer interface [polypeptide binding]; other site 1042403002421 metal binding site [ion binding]; metal-binding site 1042403002422 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1042403002423 homodimer interface [polypeptide binding]; other site 1042403002424 putative metal binding site [ion binding]; other site 1042403002425 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1042403002426 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1042403002427 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1042403002428 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1042403002429 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1042403002430 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1042403002431 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1042403002432 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1042403002433 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1042403002434 phosphopeptide binding site; other site 1042403002435 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1042403002436 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1042403002437 DNA binding residues [nucleotide binding] 1042403002438 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1042403002439 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 1042403002440 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1042403002441 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403002442 motif II; other site 1042403002443 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1042403002444 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1042403002445 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1042403002446 ATP binding site [chemical binding]; other site 1042403002447 putative Mg++ binding site [ion binding]; other site 1042403002448 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403002449 nucleotide binding region [chemical binding]; other site 1042403002450 ATP-binding site [chemical binding]; other site 1042403002451 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1042403002452 Predicted transcriptional regulator [Transcription]; Region: COG2378 1042403002453 WYL domain; Region: WYL; pfam13280 1042403002454 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1042403002455 active site 1042403002456 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 1042403002457 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1042403002458 active site 1042403002459 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1042403002460 CMP-binding site; other site 1042403002461 The sites determining sugar specificity; other site 1042403002462 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1042403002463 G1 box; other site 1042403002464 GTP/Mg2+ binding site [chemical binding]; other site 1042403002465 Switch I region; other site 1042403002466 G2 box; other site 1042403002467 Switch II region; other site 1042403002468 G3 box; other site 1042403002469 G4 box; other site 1042403002470 G5 box; other site 1042403002471 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1042403002472 G1 box; other site 1042403002473 GTP/Mg2+ binding site [chemical binding]; other site 1042403002474 Switch I region; other site 1042403002475 G2 box; other site 1042403002476 G3 box; other site 1042403002477 Switch II region; other site 1042403002478 G4 box; other site 1042403002479 G5 box; other site 1042403002480 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1042403002481 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1042403002482 RNA binding surface [nucleotide binding]; other site 1042403002483 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1042403002484 active site 1042403002485 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1042403002486 amphipathic channel; other site 1042403002487 Asn-Pro-Ala signature motifs; other site 1042403002488 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1042403002489 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1042403002490 purine monophosphate binding site [chemical binding]; other site 1042403002491 dimer interface [polypeptide binding]; other site 1042403002492 putative catalytic residues [active] 1042403002493 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1042403002494 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1042403002495 CoA binding domain; Region: CoA_binding; pfam02629 1042403002496 CoA-ligase; Region: Ligase_CoA; pfam00549 1042403002497 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1042403002498 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1042403002499 CoA-ligase; Region: Ligase_CoA; pfam00549 1042403002500 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1042403002501 active site 1042403002502 Preprotein translocase subunit; Region: YajC; pfam02699 1042403002503 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1042403002504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403002505 Walker A motif; other site 1042403002506 ATP binding site [chemical binding]; other site 1042403002507 Walker B motif; other site 1042403002508 arginine finger; other site 1042403002509 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1042403002510 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1042403002511 RuvA N terminal domain; Region: RuvA_N; pfam01330 1042403002512 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1042403002513 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1042403002514 active site 1042403002515 putative DNA-binding cleft [nucleotide binding]; other site 1042403002516 dimer interface [polypeptide binding]; other site 1042403002517 hypothetical protein; Validated; Region: PRK00110 1042403002518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1042403002519 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1042403002520 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK07920 1042403002521 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1042403002522 putative acyl-acceptor binding pocket; other site 1042403002523 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1042403002524 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1042403002525 thiS-thiF/thiG interaction site; other site 1042403002526 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1042403002527 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1042403002528 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1042403002529 active site 1042403002530 dimer interface [polypeptide binding]; other site 1042403002531 motif 1; other site 1042403002532 motif 2; other site 1042403002533 motif 3; other site 1042403002534 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1042403002535 anticodon binding site; other site 1042403002536 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1042403002537 ABC transporter; Region: ABC_tran; pfam00005 1042403002538 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1042403002539 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1042403002540 Coenzyme A binding pocket [chemical binding]; other site 1042403002541 PAC2 family; Region: PAC2; pfam09754 1042403002542 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1042403002543 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1042403002544 chaperone protein DnaJ; Provisional; Region: PRK14278 1042403002545 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1042403002546 HSP70 interaction site [polypeptide binding]; other site 1042403002547 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1042403002548 Zn binding sites [ion binding]; other site 1042403002549 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1042403002550 dimer interface [polypeptide binding]; other site 1042403002551 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1042403002552 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1042403002553 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1042403002554 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1042403002555 TPP-binding site [chemical binding]; other site 1042403002556 dimer interface [polypeptide binding]; other site 1042403002557 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1042403002558 PYR/PP interface [polypeptide binding]; other site 1042403002559 dimer interface [polypeptide binding]; other site 1042403002560 TPP binding site [chemical binding]; other site 1042403002561 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1042403002562 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1042403002563 putative active site [active] 1042403002564 transaldolase; Provisional; Region: PRK03903 1042403002565 catalytic residue [active] 1042403002566 hypothetical protein; Validated; Region: PRK07682 1042403002567 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403002568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403002569 homodimer interface [polypeptide binding]; other site 1042403002570 catalytic residue [active] 1042403002571 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1042403002572 AsnC family; Region: AsnC_trans_reg; pfam01037 1042403002573 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 1042403002574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1042403002575 non-specific DNA binding site [nucleotide binding]; other site 1042403002576 salt bridge; other site 1042403002577 sequence-specific DNA binding site [nucleotide binding]; other site 1042403002578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403002579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403002580 homodimer interface [polypeptide binding]; other site 1042403002581 catalytic residue [active] 1042403002582 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1042403002583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403002584 active site 1042403002585 motif I; other site 1042403002586 motif II; other site 1042403002587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403002588 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1042403002589 triosephosphate isomerase; Provisional; Region: PRK14567 1042403002590 substrate binding site [chemical binding]; other site 1042403002591 dimer interface [polypeptide binding]; other site 1042403002592 catalytic triad [active] 1042403002593 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1042403002594 Phosphoglycerate kinase; Region: PGK; pfam00162 1042403002595 substrate binding site [chemical binding]; other site 1042403002596 hinge regions; other site 1042403002597 ADP binding site [chemical binding]; other site 1042403002598 catalytic site [active] 1042403002599 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1042403002600 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1042403002601 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1042403002602 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1042403002603 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1042403002604 shikimate binding site; other site 1042403002605 NAD(P) binding site [chemical binding]; other site 1042403002606 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 1042403002607 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1042403002608 GIY-YIG motif/motif A; other site 1042403002609 active site 1042403002610 catalytic site [active] 1042403002611 putative DNA binding site [nucleotide binding]; other site 1042403002612 metal binding site [ion binding]; metal-binding site 1042403002613 UvrB/uvrC motif; Region: UVR; pfam02151 1042403002614 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1042403002615 Helix-hairpin-helix motif; Region: HHH; pfam00633 1042403002616 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1042403002617 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1042403002618 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1042403002619 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1042403002620 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1042403002621 putative active site [active] 1042403002622 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1042403002623 Predicted esterase [General function prediction only]; Region: COG0400 1042403002624 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1042403002625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403002626 Walker A/P-loop; other site 1042403002627 ATP binding site [chemical binding]; other site 1042403002628 Q-loop/lid; other site 1042403002629 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1042403002630 ABC transporter signature motif; other site 1042403002631 Walker B; other site 1042403002632 D-loop; other site 1042403002633 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1042403002634 Cation efflux family; Region: Cation_efflux; pfam01545 1042403002635 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1042403002636 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 1042403002637 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 1042403002638 active site 1042403002639 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1042403002640 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1042403002641 putative substrate binding site [chemical binding]; other site 1042403002642 putative ATP binding site [chemical binding]; other site 1042403002643 peroxiredoxin; Region: AhpC; TIGR03137 1042403002644 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1042403002645 dimer interface [polypeptide binding]; other site 1042403002646 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1042403002647 catalytic triad [active] 1042403002648 peroxidatic and resolving cysteines [active] 1042403002649 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1042403002650 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1042403002651 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1042403002652 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1042403002653 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1042403002654 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1042403002655 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1042403002656 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1042403002657 dimerization interface [polypeptide binding]; other site 1042403002658 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1042403002659 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403002660 motif II; other site 1042403002661 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 1042403002662 putative active site [active] 1042403002663 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1042403002664 Predicted transcriptional regulators [Transcription]; Region: COG1733 1042403002665 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1042403002666 putative acetyltransferase; Provisional; Region: PRK03624 1042403002667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1042403002668 Coenzyme A binding pocket [chemical binding]; other site 1042403002669 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1042403002670 active site 1042403002671 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1042403002672 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1042403002673 heterodimer interface [polypeptide binding]; other site 1042403002674 active site 1042403002675 FMN binding site [chemical binding]; other site 1042403002676 homodimer interface [polypeptide binding]; other site 1042403002677 substrate binding site [chemical binding]; other site 1042403002678 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1042403002679 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1042403002680 FAD binding pocket [chemical binding]; other site 1042403002681 FAD binding motif [chemical binding]; other site 1042403002682 phosphate binding motif [ion binding]; other site 1042403002683 beta-alpha-beta structure motif; other site 1042403002684 NAD binding pocket [chemical binding]; other site 1042403002685 Iron coordination center [ion binding]; other site 1042403002686 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1042403002687 active site 1042403002688 dimer interface [polypeptide binding]; other site 1042403002689 dihydroorotase; Validated; Region: pyrC; PRK09357 1042403002690 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1042403002691 active site 1042403002692 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1042403002693 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1042403002694 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1042403002695 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1042403002696 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1042403002697 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1042403002698 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1042403002699 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1042403002700 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1042403002701 metal binding triad; other site 1042403002702 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1042403002703 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1042403002704 metal binding triad; other site 1042403002705 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1042403002706 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1042403002707 FAD binding site [chemical binding]; other site 1042403002708 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1042403002709 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1042403002710 THF binding site; other site 1042403002711 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1042403002712 substrate binding site [chemical binding]; other site 1042403002713 THF binding site; other site 1042403002714 zinc-binding site [ion binding]; other site 1042403002715 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403002716 catalytic core [active] 1042403002717 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1042403002718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1042403002719 S-adenosylmethionine binding site [chemical binding]; other site 1042403002720 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1042403002721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403002722 Walker A/P-loop; other site 1042403002723 ATP binding site [chemical binding]; other site 1042403002724 Q-loop/lid; other site 1042403002725 ABC transporter signature motif; other site 1042403002726 Walker B; other site 1042403002727 D-loop; other site 1042403002728 H-loop/switch region; other site 1042403002729 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 1042403002730 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1042403002731 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1042403002732 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1042403002733 catalytic triad [active] 1042403002734 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1042403002735 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1042403002736 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1042403002737 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1042403002738 active site 1042403002739 dimer interface [polypeptide binding]; other site 1042403002740 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1042403002741 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1042403002742 active site 1042403002743 FMN binding site [chemical binding]; other site 1042403002744 substrate binding site [chemical binding]; other site 1042403002745 3Fe-4S cluster binding site [ion binding]; other site 1042403002746 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1042403002747 domain interface; other site 1042403002748 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1042403002749 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1042403002750 FeS/SAM binding site; other site 1042403002751 HemN C-terminal domain; Region: HemN_C; pfam06969 1042403002752 GTP-binding protein LepA; Provisional; Region: PRK05433 1042403002753 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1042403002754 G1 box; other site 1042403002755 putative GEF interaction site [polypeptide binding]; other site 1042403002756 GTP/Mg2+ binding site [chemical binding]; other site 1042403002757 Switch I region; other site 1042403002758 G2 box; other site 1042403002759 G3 box; other site 1042403002760 Switch II region; other site 1042403002761 G4 box; other site 1042403002762 G5 box; other site 1042403002763 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1042403002764 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1042403002765 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1042403002766 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1042403002767 UPF0126 domain; Region: UPF0126; pfam03458 1042403002768 Predicted membrane protein [Function unknown]; Region: COG2860 1042403002769 UPF0126 domain; Region: UPF0126; pfam03458 1042403002770 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1042403002771 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1042403002772 homodimer interface [polypeptide binding]; other site 1042403002773 substrate-cofactor binding pocket; other site 1042403002774 catalytic residue [active] 1042403002775 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1042403002776 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1042403002777 5S rRNA interface [nucleotide binding]; other site 1042403002778 CTC domain interface [polypeptide binding]; other site 1042403002779 L16 interface [polypeptide binding]; other site 1042403002780 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1042403002781 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1042403002782 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1042403002783 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1042403002784 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1042403002785 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1042403002786 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1042403002787 ligand binding site [chemical binding]; other site 1042403002788 homodimer interface [polypeptide binding]; other site 1042403002789 NAD(P) binding site [chemical binding]; other site 1042403002790 trimer interface B [polypeptide binding]; other site 1042403002791 trimer interface A [polypeptide binding]; other site 1042403002792 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1042403002793 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1042403002794 acyl-activating enzyme (AAE) consensus motif; other site 1042403002795 putative AMP binding site [chemical binding]; other site 1042403002796 putative active site [active] 1042403002797 putative CoA binding site [chemical binding]; other site 1042403002798 GTPase Era; Reviewed; Region: era; PRK00089 1042403002799 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1042403002800 G1 box; other site 1042403002801 GTP/Mg2+ binding site [chemical binding]; other site 1042403002802 Switch I region; other site 1042403002803 G2 box; other site 1042403002804 Switch II region; other site 1042403002805 G3 box; other site 1042403002806 G4 box; other site 1042403002807 G5 box; other site 1042403002808 KH domain; Region: KH_2; pfam07650 1042403002809 Domain of unknown function DUF21; Region: DUF21; pfam01595 1042403002810 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1042403002811 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1042403002812 Transporter associated domain; Region: CorC_HlyC; smart01091 1042403002813 metal-binding heat shock protein; Provisional; Region: PRK00016 1042403002814 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1042403002815 PhoH-like protein; Region: PhoH; pfam02562 1042403002816 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1042403002817 nucleotide binding site/active site [active] 1042403002818 HIT family signature motif; other site 1042403002819 catalytic residue [active] 1042403002820 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1042403002821 RNA methyltransferase, RsmE family; Region: TIGR00046 1042403002822 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1042403002823 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1042403002824 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1042403002825 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 1042403002826 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1042403002827 ligand binding site; other site 1042403002828 oligomer interface; other site 1042403002829 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1042403002830 dimer interface [polypeptide binding]; other site 1042403002831 N-terminal domain interface [polypeptide binding]; other site 1042403002832 sulfate 1 binding site; other site 1042403002833 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1042403002834 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1042403002835 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1042403002836 trimerization site [polypeptide binding]; other site 1042403002837 active site 1042403002838 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1042403002839 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1042403002840 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1042403002841 catalytic residue [active] 1042403002842 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1042403002843 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1042403002844 Walker A/P-loop; other site 1042403002845 ATP binding site [chemical binding]; other site 1042403002846 Q-loop/lid; other site 1042403002847 ABC transporter signature motif; other site 1042403002848 Walker B; other site 1042403002849 D-loop; other site 1042403002850 H-loop/switch region; other site 1042403002851 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1042403002852 FeS assembly protein SufD; Region: sufD; TIGR01981 1042403002853 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1042403002854 FeS assembly protein SufB; Region: sufB; TIGR01980 1042403002855 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1042403002856 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1042403002857 CTP synthetase; Validated; Region: pyrG; PRK05380 1042403002858 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1042403002859 Catalytic site [active] 1042403002860 active site 1042403002861 UTP binding site [chemical binding]; other site 1042403002862 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1042403002863 active site 1042403002864 putative oxyanion hole; other site 1042403002865 catalytic triad [active] 1042403002866 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1042403002867 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1042403002868 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1042403002869 potential frameshift: common BLAST hit: gi|283455931|ref|YP_003360495.1| Pullulanase 1042403002870 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1042403002871 active site 1042403002872 catalytic site [active] 1042403002873 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1042403002874 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1042403002875 active site 1042403002876 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1042403002877 catalytic nucleophile [active] 1042403002878 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 1042403002879 GIY-YIG motif/motif A; other site 1042403002880 putative active site [active] 1042403002881 putative metal binding site [ion binding]; other site 1042403002882 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1042403002883 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1042403002884 trimer interface [polypeptide binding]; other site 1042403002885 active site 1042403002886 dimer interface [polypeptide binding]; other site 1042403002887 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 1042403002888 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1042403002889 ADP binding site [chemical binding]; other site 1042403002890 magnesium binding site [ion binding]; other site 1042403002891 putative shikimate binding site; other site 1042403002892 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1042403002893 active site 1042403002894 dimer interface [polypeptide binding]; other site 1042403002895 metal binding site [ion binding]; metal-binding site 1042403002896 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1042403002897 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1042403002898 Tetramer interface [polypeptide binding]; other site 1042403002899 active site 1042403002900 FMN-binding site [chemical binding]; other site 1042403002901 YceG-like family; Region: YceG; pfam02618 1042403002902 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1042403002903 dimerization interface [polypeptide binding]; other site 1042403002904 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1042403002905 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1042403002906 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1042403002907 motif 1; other site 1042403002908 active site 1042403002909 motif 2; other site 1042403002910 motif 3; other site 1042403002911 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1042403002912 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403002913 catalytic core [active] 1042403002914 Membrane protein of unknown function; Region: DUF360; pfam04020 1042403002915 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1042403002916 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1042403002917 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1042403002918 RNA binding surface [nucleotide binding]; other site 1042403002919 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1042403002920 Part of AAA domain; Region: AAA_19; pfam13245 1042403002921 Family description; Region: UvrD_C_2; pfam13538 1042403002922 xanthine permease; Region: pbuX; TIGR03173 1042403002923 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 1042403002924 succinyldiaminopimelate transaminase; Region: DapC; TIGR03537 1042403002925 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403002926 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403002927 homodimer interface [polypeptide binding]; other site 1042403002928 catalytic residue [active] 1042403002929 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1042403002930 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1042403002931 active site 1042403002932 Na/Ca binding site [ion binding]; other site 1042403002933 catalytic site [active] 1042403002934 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1042403002935 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1042403002936 catalytic triad [active] 1042403002937 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1042403002938 putative deacylase active site [active] 1042403002939 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1042403002940 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1042403002941 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1042403002942 Walker A/P-loop; other site 1042403002943 ATP binding site [chemical binding]; other site 1042403002944 Q-loop/lid; other site 1042403002945 ABC transporter signature motif; other site 1042403002946 Walker B; other site 1042403002947 D-loop; other site 1042403002948 H-loop/switch region; other site 1042403002949 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1042403002950 DNA-binding site [nucleotide binding]; DNA binding site 1042403002951 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1042403002952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1042403002953 non-specific DNA binding site [nucleotide binding]; other site 1042403002954 salt bridge; other site 1042403002955 sequence-specific DNA binding site [nucleotide binding]; other site 1042403002956 Chorismate mutase type II; Region: CM_2; cl00693 1042403002957 hypothetical protein; Provisional; Region: PRK06761 1042403002958 hypothetical protein; Provisional; Region: PRK06761 1042403002959 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1042403002960 Coenzyme A binding pocket [chemical binding]; other site 1042403002961 AAA domain; Region: AAA_17; pfam13207 1042403002962 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1042403002963 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1042403002964 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1042403002965 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1042403002966 G1 box; other site 1042403002967 putative GEF interaction site [polypeptide binding]; other site 1042403002968 GTP/Mg2+ binding site [chemical binding]; other site 1042403002969 Switch I region; other site 1042403002970 G2 box; other site 1042403002971 G3 box; other site 1042403002972 Switch II region; other site 1042403002973 G4 box; other site 1042403002974 G5 box; other site 1042403002975 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1042403002976 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1042403002977 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1042403002978 Transposase domain (DUF772); Region: DUF772; pfam05598 1042403002979 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1042403002980 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 1042403002981 GMP synthase; Reviewed; Region: guaA; PRK00074 1042403002982 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1042403002983 AMP/PPi binding site [chemical binding]; other site 1042403002984 candidate oxyanion hole; other site 1042403002985 catalytic triad [active] 1042403002986 potential glutamine specificity residues [chemical binding]; other site 1042403002987 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1042403002988 ATP Binding subdomain [chemical binding]; other site 1042403002989 Ligand Binding sites [chemical binding]; other site 1042403002990 Dimerization subdomain; other site 1042403002991 putative phosphoketolase; Provisional; Region: PRK05261 1042403002992 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 1042403002993 TPP-binding site; other site 1042403002994 XFP C-terminal domain; Region: XFP_C; pfam09363 1042403002995 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1042403002996 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1042403002997 propionate/acetate kinase; Provisional; Region: PRK12379 1042403002998 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1042403002999 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1042403003000 hinge; other site 1042403003001 active site 1042403003002 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 1042403003003 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1042403003004 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1042403003005 active site 1042403003006 catalytic site [active] 1042403003007 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1042403003008 dimer interface [polypeptide binding]; other site 1042403003009 ADP-ribose binding site [chemical binding]; other site 1042403003010 active site 1042403003011 nudix motif; other site 1042403003012 metal binding site [ion binding]; metal-binding site 1042403003013 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1042403003014 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1042403003015 DNA polymerase I; Provisional; Region: PRK05755 1042403003016 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1042403003017 active site 1042403003018 metal binding site 1 [ion binding]; metal-binding site 1042403003019 putative 5' ssDNA interaction site; other site 1042403003020 metal binding site 3; metal-binding site 1042403003021 metal binding site 2 [ion binding]; metal-binding site 1042403003022 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1042403003023 putative DNA binding site [nucleotide binding]; other site 1042403003024 putative metal binding site [ion binding]; other site 1042403003025 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1042403003026 active site 1042403003027 substrate binding site [chemical binding]; other site 1042403003028 catalytic site [active] 1042403003029 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1042403003030 active site 1042403003031 DNA binding site [nucleotide binding] 1042403003032 catalytic site [active] 1042403003033 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1042403003034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1042403003035 active site 1042403003036 phosphorylation site [posttranslational modification] 1042403003037 intermolecular recognition site; other site 1042403003038 dimerization interface [polypeptide binding]; other site 1042403003039 ANTAR domain; Region: ANTAR; pfam03861 1042403003040 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1042403003041 dimer interface [polypeptide binding]; other site 1042403003042 ADP-ribose binding site [chemical binding]; other site 1042403003043 active site 1042403003044 nudix motif; other site 1042403003045 metal binding site [ion binding]; metal-binding site 1042403003046 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1042403003047 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1042403003048 domain interfaces; other site 1042403003049 active site 1042403003050 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1042403003051 excinuclease ABC subunit B; Provisional; Region: PRK05298 1042403003052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1042403003053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403003054 nucleotide binding region [chemical binding]; other site 1042403003055 ATP-binding site [chemical binding]; other site 1042403003056 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1042403003057 UvrB/uvrC motif; Region: UVR; pfam02151 1042403003058 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1042403003059 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1042403003060 CoA-binding site [chemical binding]; other site 1042403003061 ATP-binding [chemical binding]; other site 1042403003062 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1042403003063 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1042403003064 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1042403003065 homodimer interface [polypeptide binding]; other site 1042403003066 NADP binding site [chemical binding]; other site 1042403003067 substrate binding site [chemical binding]; other site 1042403003068 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1042403003069 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1042403003070 intersubunit interface [polypeptide binding]; other site 1042403003071 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1042403003072 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1042403003073 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1042403003074 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1042403003075 ABC-ATPase subunit interface; other site 1042403003076 dimer interface [polypeptide binding]; other site 1042403003077 putative PBP binding regions; other site 1042403003078 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1042403003079 homotrimer interaction site [polypeptide binding]; other site 1042403003080 zinc binding site [ion binding]; other site 1042403003081 CDP-binding sites; other site 1042403003082 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1042403003083 glycogen branching enzyme; Provisional; Region: PRK05402 1042403003084 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1042403003085 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1042403003086 active site 1042403003087 catalytic site [active] 1042403003088 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1042403003089 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1042403003090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1042403003091 active site 1042403003092 phosphorylation site [posttranslational modification] 1042403003093 intermolecular recognition site; other site 1042403003094 dimerization interface [polypeptide binding]; other site 1042403003095 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1042403003096 DNA binding site [nucleotide binding] 1042403003097 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1042403003098 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1042403003099 dimerization interface [polypeptide binding]; other site 1042403003100 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1042403003101 dimer interface [polypeptide binding]; other site 1042403003102 phosphorylation site [posttranslational modification] 1042403003103 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1042403003104 ATP binding site [chemical binding]; other site 1042403003105 Mg2+ binding site [ion binding]; other site 1042403003106 G-X-G motif; other site 1042403003107 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1042403003108 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1042403003109 active site 1042403003110 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1042403003111 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1042403003112 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1042403003113 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1042403003114 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1042403003115 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1042403003116 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1042403003117 Transcription factor WhiB; Region: Whib; pfam02467 1042403003118 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1042403003119 PAS fold; Region: PAS_4; pfam08448 1042403003120 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1042403003121 Histidine kinase; Region: HisKA_2; pfam07568 1042403003122 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1042403003123 ATP binding site [chemical binding]; other site 1042403003124 Mg2+ binding site [ion binding]; other site 1042403003125 G-X-G motif; other site 1042403003126 V-type ATP synthase subunit E; Provisional; Region: PRK01558 1042403003127 Haemolysin-III related; Region: HlyIII; pfam03006 1042403003128 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1042403003129 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1042403003130 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1042403003131 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1042403003132 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1042403003133 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1042403003134 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1042403003135 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 1042403003136 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1042403003137 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1042403003138 Septum formation initiator; Region: DivIC; pfam04977 1042403003139 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1042403003140 enolase; Provisional; Region: eno; PRK00077 1042403003141 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1042403003142 dimer interface [polypeptide binding]; other site 1042403003143 metal binding site [ion binding]; metal-binding site 1042403003144 substrate binding pocket [chemical binding]; other site 1042403003145 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1042403003146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403003147 dimer interface [polypeptide binding]; other site 1042403003148 conserved gate region; other site 1042403003149 putative PBP binding loops; other site 1042403003150 ABC-ATPase subunit interface; other site 1042403003151 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1042403003152 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1042403003153 substrate binding pocket [chemical binding]; other site 1042403003154 membrane-bound complex binding site; other site 1042403003155 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1042403003156 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1042403003157 Walker A/P-loop; other site 1042403003158 ATP binding site [chemical binding]; other site 1042403003159 Q-loop/lid; other site 1042403003160 ABC transporter signature motif; other site 1042403003161 Walker B; other site 1042403003162 D-loop; other site 1042403003163 H-loop/switch region; other site 1042403003164 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1042403003165 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1042403003166 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1042403003167 ATP binding site [chemical binding]; other site 1042403003168 putative Mg++ binding site [ion binding]; other site 1042403003169 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403003170 nucleotide binding region [chemical binding]; other site 1042403003171 ATP-binding site [chemical binding]; other site 1042403003172 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1042403003173 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1042403003174 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1042403003175 Coenzyme A binding pocket [chemical binding]; other site 1042403003176 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1042403003177 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1042403003178 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1042403003179 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1042403003180 Protein of unknown function (DUF466); Region: DUF466; cl01082 1042403003181 carbon starvation protein A; Provisional; Region: PRK15015 1042403003182 Carbon starvation protein CstA; Region: CstA; pfam02554 1042403003183 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1042403003184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403003185 Walker B; other site 1042403003186 D-loop; other site 1042403003187 H-loop/switch region; other site 1042403003188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403003189 ABC transporter signature motif; other site 1042403003190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1042403003191 Q-loop/lid; other site 1042403003192 ABC transporter signature motif; other site 1042403003193 Walker B; other site 1042403003194 D-loop; other site 1042403003195 H-loop/switch region; other site 1042403003196 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1042403003197 MarR family; Region: MarR_2; pfam12802 1042403003198 Ubinuclein conserved middle domain; Region: UBN_AB; pfam14075 1042403003199 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 1042403003200 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1042403003201 Aspartase; Region: Aspartase; cd01357 1042403003202 active sites [active] 1042403003203 tetramer interface [polypeptide binding]; other site 1042403003204 FeoA domain; Region: FeoA; pfam04023 1042403003205 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1042403003206 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1042403003207 G1 box; other site 1042403003208 GTP/Mg2+ binding site [chemical binding]; other site 1042403003209 Switch I region; other site 1042403003210 G2 box; other site 1042403003211 G3 box; other site 1042403003212 Switch II region; other site 1042403003213 G4 box; other site 1042403003214 G5 box; other site 1042403003215 Nucleoside recognition; Region: Gate; pfam07670 1042403003216 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1042403003217 Nucleoside recognition; Region: Gate; pfam07670 1042403003218 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1042403003219 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1042403003220 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1042403003221 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1042403003222 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1042403003223 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1042403003224 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1042403003225 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1042403003226 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 1042403003227 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1042403003228 SelR domain; Region: SelR; pfam01641 1042403003229 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1042403003230 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1042403003231 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1042403003232 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1042403003233 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1042403003234 Uncharacterized conserved protein [Function unknown]; Region: COG3350 1042403003235 classical (c) SDRs; Region: SDR_c; cd05233 1042403003236 NAD(P) binding site [chemical binding]; other site 1042403003237 active site 1042403003238 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 1042403003239 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1042403003240 ATP binding site [chemical binding]; other site 1042403003241 Mg++ binding site [ion binding]; other site 1042403003242 motif III; other site 1042403003243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403003244 nucleotide binding region [chemical binding]; other site 1042403003245 ATP-binding site [chemical binding]; other site 1042403003246 Predicted membrane protein [Function unknown]; Region: COG2855 1042403003247 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1042403003248 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1042403003249 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1042403003250 substrate binding pocket [chemical binding]; other site 1042403003251 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1042403003252 GTP-binding protein YchF; Reviewed; Region: PRK09601 1042403003253 YchF GTPase; Region: YchF; cd01900 1042403003254 G1 box; other site 1042403003255 GTP/Mg2+ binding site [chemical binding]; other site 1042403003256 Switch I region; other site 1042403003257 G2 box; other site 1042403003258 Switch II region; other site 1042403003259 G3 box; other site 1042403003260 G4 box; other site 1042403003261 G5 box; other site 1042403003262 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1042403003263 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1042403003264 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1042403003265 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1042403003266 Histidine kinase; Region: HisKA_3; pfam07730 1042403003267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1042403003268 ATP binding site [chemical binding]; other site 1042403003269 Mg2+ binding site [ion binding]; other site 1042403003270 G-X-G motif; other site 1042403003271 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1042403003272 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1042403003273 active site 1042403003274 phosphorylation site [posttranslational modification] 1042403003275 intermolecular recognition site; other site 1042403003276 dimerization interface [polypeptide binding]; other site 1042403003277 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1042403003278 DNA binding residues [nucleotide binding] 1042403003279 dimerization interface [polypeptide binding]; other site 1042403003280 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1042403003281 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1042403003282 FtsX-like permease family; Region: FtsX; pfam02687 1042403003283 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1042403003284 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1042403003285 Walker A/P-loop; other site 1042403003286 ATP binding site [chemical binding]; other site 1042403003287 Q-loop/lid; other site 1042403003288 ABC transporter signature motif; other site 1042403003289 Walker B; other site 1042403003290 D-loop; other site 1042403003291 H-loop/switch region; other site 1042403003292 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1042403003293 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1042403003294 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1042403003295 Walker A/P-loop; other site 1042403003296 ATP binding site [chemical binding]; other site 1042403003297 Q-loop/lid; other site 1042403003298 ABC transporter signature motif; other site 1042403003299 Walker B; other site 1042403003300 D-loop; other site 1042403003301 H-loop/switch region; other site 1042403003302 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1042403003303 Walker A/P-loop; other site 1042403003304 ATP binding site [chemical binding]; other site 1042403003305 Q-loop/lid; other site 1042403003306 ABC transporter signature motif; other site 1042403003307 Walker B; other site 1042403003308 D-loop; other site 1042403003309 H-loop/switch region; other site 1042403003310 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1042403003311 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1042403003312 homodimer interface [polypeptide binding]; other site 1042403003313 substrate-cofactor binding pocket; other site 1042403003314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403003315 catalytic residue [active] 1042403003316 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1042403003317 dimer interface [polypeptide binding]; other site 1042403003318 pyridoxal binding site [chemical binding]; other site 1042403003319 ATP binding site [chemical binding]; other site 1042403003320 hypothetical protein; Provisional; Region: PRK14681 1042403003321 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1042403003322 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1042403003323 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403003324 Walker A motif; other site 1042403003325 ATP binding site [chemical binding]; other site 1042403003326 Walker B motif; other site 1042403003327 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1042403003328 DNA protecting protein DprA; Region: dprA; TIGR00732 1042403003329 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1042403003330 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 1042403003331 L-aspartate oxidase; Provisional; Region: PRK06175 1042403003332 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1042403003333 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1042403003334 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1042403003335 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1042403003336 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1042403003337 S-adenosylmethionine binding site [chemical binding]; other site 1042403003338 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1042403003339 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1042403003340 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1042403003341 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403003342 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403003343 homodimer interface [polypeptide binding]; other site 1042403003344 catalytic residue [active] 1042403003345 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1042403003346 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1042403003347 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403003348 Walker A motif; other site 1042403003349 ATP binding site [chemical binding]; other site 1042403003350 Walker B motif; other site 1042403003351 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1042403003352 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1042403003353 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1042403003354 oligomer interface [polypeptide binding]; other site 1042403003355 active site residues [active] 1042403003356 Clp protease; Region: CLP_protease; pfam00574 1042403003357 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1042403003358 oligomer interface [polypeptide binding]; other site 1042403003359 active site residues [active] 1042403003360 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1042403003361 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1042403003362 putative ion selectivity filter; other site 1042403003363 putative pore gating glutamate residue; other site 1042403003364 trigger factor; Provisional; Region: tig; PRK01490 1042403003365 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1042403003366 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1042403003367 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1042403003368 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1042403003369 active site 1042403003370 catalytic site [active] 1042403003371 substrate binding site [chemical binding]; other site 1042403003372 HRDC domain; Region: HRDC; pfam00570 1042403003373 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1042403003374 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1042403003375 FeS/SAM binding site; other site 1042403003376 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1042403003377 Pyruvate formate lyase 1; Region: PFL1; cd01678 1042403003378 coenzyme A binding site [chemical binding]; other site 1042403003379 active site 1042403003380 catalytic residues [active] 1042403003381 glycine loop; other site 1042403003382 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1042403003383 NAD synthetase; Provisional; Region: PRK13981 1042403003384 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1042403003385 multimer interface [polypeptide binding]; other site 1042403003386 active site 1042403003387 catalytic triad [active] 1042403003388 protein interface 1 [polypeptide binding]; other site 1042403003389 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1042403003390 homodimer interface [polypeptide binding]; other site 1042403003391 NAD binding pocket [chemical binding]; other site 1042403003392 ATP binding pocket [chemical binding]; other site 1042403003393 Mg binding site [ion binding]; other site 1042403003394 active-site loop [active] 1042403003395 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1042403003396 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1042403003397 metal binding site [ion binding]; metal-binding site 1042403003398 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1042403003399 conserved gate region; other site 1042403003400 ABC-ATPase subunit interface; other site 1042403003401 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1042403003402 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1042403003403 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1042403003404 Walker A/P-loop; other site 1042403003405 ATP binding site [chemical binding]; other site 1042403003406 Q-loop/lid; other site 1042403003407 ABC transporter signature motif; other site 1042403003408 Walker B; other site 1042403003409 D-loop; other site 1042403003410 H-loop/switch region; other site 1042403003411 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1042403003412 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1042403003413 active site 1042403003414 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1042403003415 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1042403003416 Zn2+ binding site [ion binding]; other site 1042403003417 Mg2+ binding site [ion binding]; other site 1042403003418 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1042403003419 synthetase active site [active] 1042403003420 NTP binding site [chemical binding]; other site 1042403003421 metal binding site [ion binding]; metal-binding site 1042403003422 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1042403003423 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1042403003424 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1042403003425 trimer interface [polypeptide binding]; other site 1042403003426 active site 1042403003427 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1042403003428 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1042403003429 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1042403003430 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1042403003431 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1042403003432 CAP-like domain; other site 1042403003433 active site 1042403003434 primary dimer interface [polypeptide binding]; other site 1042403003435 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1042403003436 EamA-like transporter family; Region: EamA; cl17759 1042403003437 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1042403003438 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1042403003439 ATP binding site [chemical binding]; other site 1042403003440 putative Mg++ binding site [ion binding]; other site 1042403003441 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 1042403003442 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403003443 nucleotide binding region [chemical binding]; other site 1042403003444 ATP-binding site [chemical binding]; other site 1042403003445 DEAD/H associated; Region: DEAD_assoc; pfam08494 1042403003446 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403003447 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403003448 putative substrate translocation pore; other site 1042403003449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1042403003450 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1042403003451 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1042403003452 ATP binding site [chemical binding]; other site 1042403003453 Mg2+ binding site [ion binding]; other site 1042403003454 G-X-G motif; other site 1042403003455 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1042403003456 anchoring element; other site 1042403003457 dimer interface [polypeptide binding]; other site 1042403003458 ATP binding site [chemical binding]; other site 1042403003459 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1042403003460 active site 1042403003461 putative metal-binding site [ion binding]; other site 1042403003462 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1042403003463 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1042403003464 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1042403003465 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1042403003466 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1042403003467 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1042403003468 DNA binding residues [nucleotide binding] 1042403003469 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1042403003470 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1042403003471 substrate binding pocket [chemical binding]; other site 1042403003472 chain length determination region; other site 1042403003473 substrate-Mg2+ binding site; other site 1042403003474 catalytic residues [active] 1042403003475 aspartate-rich region 1; other site 1042403003476 active site lid residues [active] 1042403003477 aspartate-rich region 2; other site 1042403003478 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1042403003479 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1042403003480 active site 1042403003481 ATP binding site [chemical binding]; other site 1042403003482 substrate binding site [chemical binding]; other site 1042403003483 activation loop (A-loop); other site 1042403003484 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1042403003485 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1042403003486 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1042403003487 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1042403003488 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1042403003489 putative acyl-acceptor binding pocket; other site 1042403003490 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 1042403003491 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1042403003492 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1042403003493 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1042403003494 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1042403003495 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1042403003496 ATP binding site [chemical binding]; other site 1042403003497 putative Mg++ binding site [ion binding]; other site 1042403003498 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1042403003499 SEC-C motif; Region: SEC-C; pfam02810 1042403003500 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1042403003501 30S subunit binding site; other site 1042403003502 RecX family; Region: RecX; pfam02631 1042403003503 recombinase A; Provisional; Region: recA; PRK09354 1042403003504 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1042403003505 hexamer interface [polypeptide binding]; other site 1042403003506 Walker A motif; other site 1042403003507 ATP binding site [chemical binding]; other site 1042403003508 Walker B motif; other site 1042403003509 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1042403003510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1042403003511 non-specific DNA binding site [nucleotide binding]; other site 1042403003512 salt bridge; other site 1042403003513 sequence-specific DNA binding site [nucleotide binding]; other site 1042403003514 Competence-damaged protein; Region: CinA; pfam02464 1042403003515 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1042403003516 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1042403003517 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1042403003518 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1042403003519 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1042403003520 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1042403003521 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1042403003522 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1042403003523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1042403003524 FeS/SAM binding site; other site 1042403003525 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1042403003526 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1042403003527 synthetase active site [active] 1042403003528 NTP binding site [chemical binding]; other site 1042403003529 metal binding site [ion binding]; metal-binding site 1042403003530 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1042403003531 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1042403003532 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 1042403003533 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1042403003534 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1042403003535 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1042403003536 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1042403003537 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403003538 Walker A/P-loop; other site 1042403003539 ATP binding site [chemical binding]; other site 1042403003540 Q-loop/lid; other site 1042403003541 ABC transporter signature motif; other site 1042403003542 Walker B; other site 1042403003543 D-loop; other site 1042403003544 H-loop/switch region; other site 1042403003545 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1042403003546 Histidine kinase; Region: HisKA_3; pfam07730 1042403003547 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1042403003548 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1042403003549 active site 1042403003550 phosphorylation site [posttranslational modification] 1042403003551 intermolecular recognition site; other site 1042403003552 dimerization interface [polypeptide binding]; other site 1042403003553 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1042403003554 DNA binding residues [nucleotide binding] 1042403003555 dimerization interface [polypeptide binding]; other site 1042403003556 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1042403003557 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1042403003558 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1042403003559 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1042403003560 active site 1042403003561 catalytic site [active] 1042403003562 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1042403003563 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1042403003564 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1042403003565 Protein of unknown function DUF262; Region: DUF262; pfam03235 1042403003566 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1042403003567 Protein of unknown function DUF262; Region: DUF262; pfam03235 1042403003568 maltose O-acetyltransferase; Provisional; Region: PRK10092 1042403003569 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1042403003570 active site 1042403003571 substrate binding site [chemical binding]; other site 1042403003572 trimer interface [polypeptide binding]; other site 1042403003573 CoA binding site [chemical binding]; other site 1042403003574 aconitate hydratase; Validated; Region: PRK09277 1042403003575 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1042403003576 substrate binding site [chemical binding]; other site 1042403003577 ligand binding site [chemical binding]; other site 1042403003578 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1042403003579 substrate binding site [chemical binding]; other site 1042403003580 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1042403003581 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1042403003582 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1042403003583 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1042403003584 Protein of unknown function (DUF418); Region: DUF418; cl12135 1042403003585 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1042403003586 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1042403003587 TRAM domain; Region: TRAM; cl01282 1042403003588 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1042403003589 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1042403003590 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 1042403003591 putative active site [active] 1042403003592 putative catalytic site [active] 1042403003593 putative DNA binding site [nucleotide binding]; other site 1042403003594 putative phosphate binding site [ion binding]; other site 1042403003595 metal binding site A [ion binding]; metal-binding site 1042403003596 putative AP binding site [nucleotide binding]; other site 1042403003597 putative metal binding site B [ion binding]; other site 1042403003598 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1042403003599 AAA domain; Region: AAA_21; pfam13304 1042403003600 Walker A/P-loop; other site 1042403003601 ATP binding site [chemical binding]; other site 1042403003602 Q-loop/lid; other site 1042403003603 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1042403003604 ABC transporter signature motif; other site 1042403003605 Walker B; other site 1042403003606 D-loop; other site 1042403003607 H-loop/switch region; other site 1042403003608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1042403003609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1042403003610 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1042403003611 Walker A/P-loop; other site 1042403003612 ATP binding site [chemical binding]; other site 1042403003613 Q-loop/lid; other site 1042403003614 ABC transporter signature motif; other site 1042403003615 Walker B; other site 1042403003616 D-loop; other site 1042403003617 H-loop/switch region; other site 1042403003618 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1042403003619 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403003620 dimer interface [polypeptide binding]; other site 1042403003621 conserved gate region; other site 1042403003622 putative PBP binding loops; other site 1042403003623 ABC-ATPase subunit interface; other site 1042403003624 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1042403003625 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1042403003626 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1042403003627 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1042403003628 active site 1042403003629 DNA binding site [nucleotide binding] 1042403003630 Int/Topo IB signature motif; other site 1042403003631 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1042403003632 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1042403003633 Walker A/P-loop; other site 1042403003634 ATP binding site [chemical binding]; other site 1042403003635 Q-loop/lid; other site 1042403003636 ABC transporter signature motif; other site 1042403003637 Walker B; other site 1042403003638 D-loop; other site 1042403003639 H-loop/switch region; other site 1042403003640 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1042403003641 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1042403003642 FtsX-like permease family; Region: FtsX; pfam02687 1042403003643 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1042403003644 FtsX-like permease family; Region: FtsX; pfam02687 1042403003645 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1042403003646 prephenate dehydrogenase; Validated; Region: PRK08507 1042403003647 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1042403003648 Prephenate dehydratase; Region: PDT; pfam00800 1042403003649 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1042403003650 putative L-Phe binding site [chemical binding]; other site 1042403003651 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1042403003652 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1042403003653 G1 box; other site 1042403003654 putative GEF interaction site [polypeptide binding]; other site 1042403003655 GTP/Mg2+ binding site [chemical binding]; other site 1042403003656 Switch I region; other site 1042403003657 G2 box; other site 1042403003658 G3 box; other site 1042403003659 Switch II region; other site 1042403003660 G4 box; other site 1042403003661 G5 box; other site 1042403003662 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1042403003663 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1042403003664 benzoate transport; Region: 2A0115; TIGR00895 1042403003665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403003666 putative substrate translocation pore; other site 1042403003667 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1042403003668 nudix motif; other site 1042403003669 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 1042403003670 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1042403003671 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1042403003672 P-loop; other site 1042403003673 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1042403003674 Magnesium ion binding site [ion binding]; other site 1042403003675 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1042403003676 Magnesium ion binding site [ion binding]; other site 1042403003677 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1042403003678 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1042403003679 active site 1042403003680 Int/Topo IB signature motif; other site 1042403003681 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1042403003682 23S rRNA binding site [nucleotide binding]; other site 1042403003683 L21 binding site [polypeptide binding]; other site 1042403003684 L13 binding site [polypeptide binding]; other site 1042403003685 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1042403003686 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1042403003687 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1042403003688 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1042403003689 Thiamine pyrophosphokinase; Region: TPK; cd07995 1042403003690 active site 1042403003691 dimerization interface [polypeptide binding]; other site 1042403003692 thiamine binding site [chemical binding]; other site 1042403003693 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1042403003694 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1042403003695 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1042403003696 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1042403003697 putative deacylase active site [active] 1042403003698 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1042403003699 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1042403003700 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1042403003701 active site 1042403003702 catalytic residues [active] 1042403003703 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1042403003704 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1042403003705 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1042403003706 DNA binding residues [nucleotide binding] 1042403003707 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1042403003708 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1042403003709 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1042403003710 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1042403003711 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1042403003712 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1042403003713 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1042403003714 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1042403003715 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1042403003716 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1042403003717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1042403003718 active site 1042403003719 phosphorylation site [posttranslational modification] 1042403003720 intermolecular recognition site; other site 1042403003721 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1042403003722 DNA binding residues [nucleotide binding] 1042403003723 dimerization interface [polypeptide binding]; other site 1042403003724 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1042403003725 Histidine kinase; Region: HisKA_3; pfam07730 1042403003726 proline aminopeptidase P II; Provisional; Region: PRK10879 1042403003727 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1042403003728 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1042403003729 active site 1042403003730 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1042403003731 nudix motif; other site 1042403003732 MarR family; Region: MarR_2; cl17246 1042403003733 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1042403003734 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1042403003735 nucleotide binding site [chemical binding]; other site 1042403003736 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1042403003737 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1042403003738 putative substrate binding site [chemical binding]; other site 1042403003739 putative ATP binding site [chemical binding]; other site 1042403003740 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1042403003741 putative active site [active] 1042403003742 dimerization interface [polypeptide binding]; other site 1042403003743 putative tRNAtyr binding site [nucleotide binding]; other site 1042403003744 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1042403003745 active site 1042403003746 DNA binding site [nucleotide binding] 1042403003747 Int/Topo IB signature motif; other site 1042403003748 Helix-turn-helix domain; Region: HTH_17; pfam12728 1042403003749 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1042403003750 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1042403003751 Walker A motif; other site 1042403003752 ATP binding site [chemical binding]; other site 1042403003753 Walker B motif; other site 1042403003754 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1042403003755 Phage capsid family; Region: Phage_capsid; pfam05065 1042403003756 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1042403003757 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1042403003758 Walker A/P-loop; other site 1042403003759 ATP binding site [chemical binding]; other site 1042403003760 Q-loop/lid; other site 1042403003761 ABC transporter signature motif; other site 1042403003762 Walker B; other site 1042403003763 D-loop; other site 1042403003764 H-loop/switch region; other site 1042403003765 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1042403003766 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1042403003767 Walker A/P-loop; other site 1042403003768 ATP binding site [chemical binding]; other site 1042403003769 Q-loop/lid; other site 1042403003770 ABC transporter signature motif; other site 1042403003771 Walker B; other site 1042403003772 D-loop; other site 1042403003773 H-loop/switch region; other site 1042403003774 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1042403003775 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1042403003776 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1042403003777 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403003778 dimer interface [polypeptide binding]; other site 1042403003779 conserved gate region; other site 1042403003780 ABC-ATPase subunit interface; other site 1042403003781 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1042403003782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403003783 dimer interface [polypeptide binding]; other site 1042403003784 conserved gate region; other site 1042403003785 putative PBP binding loops; other site 1042403003786 ABC-ATPase subunit interface; other site 1042403003787 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1042403003788 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1042403003789 cell division protein FtsQ; Provisional; Region: PRK05529 1042403003790 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1042403003791 Cell division protein FtsQ; Region: FtsQ; pfam03799 1042403003792 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1042403003793 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1042403003794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1042403003795 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1042403003796 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1042403003797 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1042403003798 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1042403003799 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1042403003800 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1042403003801 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1042403003802 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1042403003803 Mg++ binding site [ion binding]; other site 1042403003804 putative catalytic motif [active] 1042403003805 putative substrate binding site [chemical binding]; other site 1042403003806 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1042403003807 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1042403003808 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1042403003809 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1042403003810 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 1042403003811 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1042403003812 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1042403003813 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1042403003814 MraW methylase family; Region: Methyltransf_5; cl17771 1042403003815 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1042403003816 MraZ protein; Region: MraZ; pfam02381 1042403003817 cell division protein MraZ; Reviewed; Region: PRK00326 1042403003818 MraZ protein; Region: MraZ; pfam02381 1042403003819 Part of AAA domain; Region: AAA_19; pfam13245 1042403003820 Family description; Region: UvrD_C_2; pfam13538 1042403003821 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1042403003822 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1042403003823 ligand binding site [chemical binding]; other site 1042403003824 NAD binding site [chemical binding]; other site 1042403003825 tetramer interface [polypeptide binding]; other site 1042403003826 catalytic site [active] 1042403003827 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1042403003828 L-serine binding site [chemical binding]; other site 1042403003829 ACT domain interface; other site 1042403003830 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1042403003831 ATP cone domain; Region: ATP-cone; pfam03477 1042403003832 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1042403003833 LexA repressor; Validated; Region: PRK00215 1042403003834 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1042403003835 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1042403003836 Catalytic site [active] 1042403003837 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1042403003838 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1042403003839 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1042403003840 NAD binding site [chemical binding]; other site 1042403003841 dimer interface [polypeptide binding]; other site 1042403003842 substrate binding site [chemical binding]; other site 1042403003843 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1042403003844 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1042403003845 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1042403003846 HflX GTPase family; Region: HflX; cd01878 1042403003847 G1 box; other site 1042403003848 GTP/Mg2+ binding site [chemical binding]; other site 1042403003849 Switch I region; other site 1042403003850 G2 box; other site 1042403003851 G3 box; other site 1042403003852 Switch II region; other site 1042403003853 G4 box; other site 1042403003854 G5 box; other site 1042403003855 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1042403003856 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1042403003857 S-adenosylmethionine binding site [chemical binding]; other site 1042403003858 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 1042403003859 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1042403003860 ATP binding site [chemical binding]; other site 1042403003861 putative Mg++ binding site [ion binding]; other site 1042403003862 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1042403003863 nucleotide binding region [chemical binding]; other site 1042403003864 ATP-binding site [chemical binding]; other site 1042403003865 Helicase associated domain (HA2); Region: HA2; pfam04408 1042403003866 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1042403003867 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1042403003868 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1042403003869 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1042403003870 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1042403003871 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1042403003872 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1042403003873 catalytic residues [active] 1042403003874 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1042403003875 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1042403003876 putative active site [active] 1042403003877 oxyanion strand; other site 1042403003878 catalytic triad [active] 1042403003879 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1042403003880 putative active site pocket [active] 1042403003881 4-fold oligomerization interface [polypeptide binding]; other site 1042403003882 metal binding residues [ion binding]; metal-binding site 1042403003883 3-fold/trimer interface [polypeptide binding]; other site 1042403003884 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1042403003885 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403003886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403003887 homodimer interface [polypeptide binding]; other site 1042403003888 catalytic residue [active] 1042403003889 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1042403003890 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1042403003891 NAD binding site [chemical binding]; other site 1042403003892 dimerization interface [polypeptide binding]; other site 1042403003893 product binding site; other site 1042403003894 substrate binding site [chemical binding]; other site 1042403003895 zinc binding site [ion binding]; other site 1042403003896 catalytic residues [active] 1042403003897 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1042403003898 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1042403003899 active site 1042403003900 PHP Thumb interface [polypeptide binding]; other site 1042403003901 metal binding site [ion binding]; metal-binding site 1042403003902 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1042403003903 generic binding surface I; other site 1042403003904 generic binding surface II; other site 1042403003905 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1042403003906 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 1042403003907 RNA binding surface [nucleotide binding]; other site 1042403003908 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1042403003909 active site 1042403003910 lipoprotein signal peptidase; Provisional; Region: PRK14771 1042403003911 DivIVA protein; Region: DivIVA; pfam05103 1042403003912 DivIVA domain; Region: DivI1A_domain; TIGR03544 1042403003913 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 1042403003914 YGGT family; Region: YGGT; pfam02325 1042403003915 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1042403003916 cell division protein FtsZ; Validated; Region: PRK09330 1042403003917 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1042403003918 nucleotide binding site [chemical binding]; other site 1042403003919 SulA interaction site; other site 1042403003920 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1042403003921 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1042403003922 FMN binding site [chemical binding]; other site 1042403003923 active site 1042403003924 catalytic residues [active] 1042403003925 substrate binding site [chemical binding]; other site 1042403003926 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1042403003927 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1042403003928 motif 1; other site 1042403003929 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1042403003930 active site 1042403003931 motif 2; other site 1042403003932 motif 3; other site 1042403003933 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1042403003934 anticodon binding site; other site 1042403003935 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1042403003936 thiamine phosphate binding site [chemical binding]; other site 1042403003937 active site 1042403003938 pyrophosphate binding site [ion binding]; other site 1042403003939 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1042403003940 substrate binding site [chemical binding]; other site 1042403003941 dimer interface [polypeptide binding]; other site 1042403003942 ATP binding site [chemical binding]; other site 1042403003943 Domain of unknown function DUF77; Region: DUF77; pfam01910 1042403003944 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403003945 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403003946 DNA binding site [nucleotide binding] 1042403003947 domain linker motif; other site 1042403003948 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1042403003949 putative dimerization interface [polypeptide binding]; other site 1042403003950 putative ligand binding site [chemical binding]; other site 1042403003951 galactoside permease; Reviewed; Region: lacY; PRK09528 1042403003952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403003953 putative substrate translocation pore; other site 1042403003954 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 1042403003955 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1042403003956 substrate binding [chemical binding]; other site 1042403003957 active site 1042403003958 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1042403003959 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1042403003960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403003961 dimer interface [polypeptide binding]; other site 1042403003962 conserved gate region; other site 1042403003963 putative PBP binding loops; other site 1042403003964 ABC-ATPase subunit interface; other site 1042403003965 NMT1/THI5 like; Region: NMT1; pfam09084 1042403003966 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1042403003967 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 1042403003968 active site 1042403003969 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 1042403003970 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1042403003971 catalytic residue [active] 1042403003972 putative FPP diphosphate binding site; other site 1042403003973 putative FPP binding hydrophobic cleft; other site 1042403003974 dimer interface [polypeptide binding]; other site 1042403003975 putative IPP diphosphate binding site; other site 1042403003976 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1042403003977 Recombination protein O N terminal; Region: RecO_N; pfam11967 1042403003978 Recombination protein O C terminal; Region: RecO_C; pfam02565 1042403003979 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1042403003980 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1042403003981 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1042403003982 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1042403003983 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1042403003984 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1042403003985 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1042403003986 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1042403003987 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1042403003988 DivIVA domain; Region: DivI1A_domain; TIGR03544 1042403003989 DivIVA domain; Region: DivI1A_domain; TIGR03544 1042403003990 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1042403003991 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1042403003992 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1042403003993 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1042403003994 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1042403003995 Part of AAA domain; Region: AAA_19; pfam13245 1042403003996 Family description; Region: UvrD_C_2; pfam13538 1042403003997 Phosphotransferase enzyme family; Region: APH; pfam01636 1042403003998 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1042403003999 substrate binding site [chemical binding]; other site 1042403004000 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1042403004001 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1042403004002 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1042403004003 active site 1042403004004 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1042403004005 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1042403004006 putative active site [active] 1042403004007 redox center [active] 1042403004008 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1042403004009 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1042403004010 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1042403004011 glutamate racemase; Provisional; Region: PRK00865 1042403004012 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1042403004013 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1042403004014 active site 1042403004015 nucleophile elbow; other site 1042403004016 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1042403004017 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1042403004018 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1042403004019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1042403004020 substrate binding pocket [chemical binding]; other site 1042403004021 membrane-bound complex binding site; other site 1042403004022 hinge residues; other site 1042403004023 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1042403004024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403004025 Walker A/P-loop; other site 1042403004026 ATP binding site [chemical binding]; other site 1042403004027 Q-loop/lid; other site 1042403004028 ABC transporter signature motif; other site 1042403004029 Walker B; other site 1042403004030 D-loop; other site 1042403004031 H-loop/switch region; other site 1042403004032 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1042403004033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004034 dimer interface [polypeptide binding]; other site 1042403004035 conserved gate region; other site 1042403004036 putative PBP binding loops; other site 1042403004037 ABC-ATPase subunit interface; other site 1042403004038 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1042403004039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004040 dimer interface [polypeptide binding]; other site 1042403004041 conserved gate region; other site 1042403004042 putative PBP binding loops; other site 1042403004043 ABC-ATPase subunit interface; other site 1042403004044 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 1042403004045 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403004046 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403004047 homodimer interface [polypeptide binding]; other site 1042403004048 catalytic residue [active] 1042403004049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004050 putative PBP binding loops; other site 1042403004051 ABC-ATPase subunit interface; other site 1042403004052 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1042403004053 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1042403004054 Walker A/P-loop; other site 1042403004055 ATP binding site [chemical binding]; other site 1042403004056 Q-loop/lid; other site 1042403004057 ABC transporter signature motif; other site 1042403004058 Walker B; other site 1042403004059 D-loop; other site 1042403004060 H-loop/switch region; other site 1042403004061 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1042403004062 NIL domain; Region: NIL; pfam09383 1042403004063 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 1042403004064 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1042403004065 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 1042403004066 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1042403004067 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1042403004068 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1042403004069 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1042403004070 active site 1042403004071 catalytic site [active] 1042403004072 substrate binding site [chemical binding]; other site 1042403004073 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1042403004074 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1042403004075 G1 box; other site 1042403004076 putative GEF interaction site [polypeptide binding]; other site 1042403004077 GTP/Mg2+ binding site [chemical binding]; other site 1042403004078 Switch I region; other site 1042403004079 G2 box; other site 1042403004080 G3 box; other site 1042403004081 Switch II region; other site 1042403004082 G4 box; other site 1042403004083 G5 box; other site 1042403004084 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1042403004085 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 1042403004086 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1042403004087 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1042403004088 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1042403004089 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1042403004090 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403004091 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403004092 putative substrate translocation pore; other site 1042403004093 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 1042403004094 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 1042403004095 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1042403004096 HIGH motif; other site 1042403004097 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1042403004098 active site 1042403004099 KMSKS motif; other site 1042403004100 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1042403004101 tRNA binding surface [nucleotide binding]; other site 1042403004102 anticodon binding site; other site 1042403004103 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1042403004104 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1042403004105 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1042403004106 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1042403004107 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1042403004108 Walker A/P-loop; other site 1042403004109 ATP binding site [chemical binding]; other site 1042403004110 Q-loop/lid; other site 1042403004111 ABC transporter signature motif; other site 1042403004112 Walker B; other site 1042403004113 D-loop; other site 1042403004114 H-loop/switch region; other site 1042403004115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1042403004116 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1042403004117 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403004118 Walker A/P-loop; other site 1042403004119 ATP binding site [chemical binding]; other site 1042403004120 Q-loop/lid; other site 1042403004121 ABC transporter signature motif; other site 1042403004122 Walker B; other site 1042403004123 D-loop; other site 1042403004124 H-loop/switch region; other site 1042403004125 MarR family; Region: MarR_2; pfam12802 1042403004126 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1042403004127 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1042403004128 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1042403004129 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1042403004130 additional DNA contacts [nucleotide binding]; other site 1042403004131 mismatch recognition site; other site 1042403004132 active site 1042403004133 zinc binding site [ion binding]; other site 1042403004134 DNA intercalation site [nucleotide binding]; other site 1042403004135 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 1042403004136 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1042403004137 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1042403004138 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 1042403004139 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 1042403004140 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 1042403004141 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1042403004142 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1042403004143 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1042403004144 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1042403004145 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1042403004146 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1042403004147 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1042403004148 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1042403004149 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 1042403004150 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1042403004151 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1042403004152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1042403004153 FeS/SAM binding site; other site 1042403004154 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1042403004155 ATP cone domain; Region: ATP-cone; pfam03477 1042403004156 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1042403004157 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1042403004158 active site 1042403004159 Zn binding site [ion binding]; other site 1042403004160 glycine loop; other site 1042403004161 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1042403004162 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1042403004163 generic binding surface II; other site 1042403004164 generic binding surface I; other site 1042403004165 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1042403004166 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1042403004167 putative catalytic site [active] 1042403004168 putative metal binding site [ion binding]; other site 1042403004169 putative phosphate binding site [ion binding]; other site 1042403004170 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 1042403004171 aminotransferase; Validated; Region: PRK07337 1042403004172 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1042403004173 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403004174 homodimer interface [polypeptide binding]; other site 1042403004175 catalytic residue [active] 1042403004176 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1042403004177 additional DNA contacts [nucleotide binding]; other site 1042403004178 mismatch recognition site; other site 1042403004179 active site 1042403004180 zinc binding site [ion binding]; other site 1042403004181 DNA intercalation site [nucleotide binding]; other site 1042403004182 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1042403004183 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1042403004184 active site 1042403004185 catalytic site [active] 1042403004186 substrate binding site [chemical binding]; other site 1042403004187 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1042403004188 active site 1042403004189 catalytic residues [active] 1042403004190 metal binding site [ion binding]; metal-binding site 1042403004191 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1042403004192 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1042403004193 active site 1042403004194 substrate binding site [chemical binding]; other site 1042403004195 metal binding site [ion binding]; metal-binding site 1042403004196 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1042403004197 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1042403004198 Zn binding site [ion binding]; other site 1042403004199 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1042403004200 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1042403004201 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1042403004202 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1042403004203 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1042403004204 dimer interface [polypeptide binding]; other site 1042403004205 active site 1042403004206 catalytic residue [active] 1042403004207 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1042403004208 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1042403004209 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1042403004210 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403004211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403004212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1042403004213 Coenzyme A binding pocket [chemical binding]; other site 1042403004214 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1042403004215 Family description; Region: UvrD_C_2; pfam13538 1042403004216 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1042403004217 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1042403004218 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1042403004219 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1042403004220 active site 1042403004221 ATP binding site [chemical binding]; other site 1042403004222 substrate binding site [chemical binding]; other site 1042403004223 activation loop (A-loop); other site 1042403004224 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1042403004225 Interdomain contacts; other site 1042403004226 Cytokine receptor motif; other site 1042403004227 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1042403004228 Interdomain contacts; other site 1042403004229 Cytokine receptor motif; other site 1042403004230 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1042403004231 Protein of unknown function DUF58; Region: DUF58; pfam01882 1042403004232 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1042403004233 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1042403004234 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1042403004235 phosphopeptide binding site; other site 1042403004236 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1042403004237 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1042403004238 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1042403004239 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1042403004240 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1042403004241 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1042403004242 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1042403004243 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1042403004244 DNA binding site [nucleotide binding] 1042403004245 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1042403004246 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1042403004247 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1042403004248 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1042403004249 RPB1 interaction site [polypeptide binding]; other site 1042403004250 RPB10 interaction site [polypeptide binding]; other site 1042403004251 RPB11 interaction site [polypeptide binding]; other site 1042403004252 RPB3 interaction site [polypeptide binding]; other site 1042403004253 RPB12 interaction site [polypeptide binding]; other site 1042403004254 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1042403004255 endonuclease III; Region: ENDO3c; smart00478 1042403004256 minor groove reading motif; other site 1042403004257 helix-hairpin-helix signature motif; other site 1042403004258 substrate binding pocket [chemical binding]; other site 1042403004259 active site 1042403004260 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1042403004261 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1042403004262 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1042403004263 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1042403004264 active site 1042403004265 catalytic site [active] 1042403004266 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1042403004267 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1042403004268 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1042403004269 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1042403004270 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1042403004271 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1042403004272 dimer interface [polypeptide binding]; other site 1042403004273 active site 1042403004274 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1042403004275 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1042403004276 DNA-binding site [nucleotide binding]; DNA binding site 1042403004277 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1042403004278 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1042403004279 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1042403004280 quinone interaction residues [chemical binding]; other site 1042403004281 active site 1042403004282 catalytic residues [active] 1042403004283 FMN binding site [chemical binding]; other site 1042403004284 substrate binding site [chemical binding]; other site 1042403004285 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1042403004286 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1042403004287 active site 1042403004288 FMN binding site [chemical binding]; other site 1042403004289 substrate binding site [chemical binding]; other site 1042403004290 homotetramer interface [polypeptide binding]; other site 1042403004291 catalytic residue [active] 1042403004292 Transglycosylase; Region: Transgly; pfam00912 1042403004293 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1042403004294 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1042403004295 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1042403004296 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1042403004297 ligand binding site [chemical binding]; other site 1042403004298 flexible hinge region; other site 1042403004299 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1042403004300 putative switch regulator; other site 1042403004301 non-specific DNA interactions [nucleotide binding]; other site 1042403004302 DNA binding site [nucleotide binding] 1042403004303 sequence specific DNA binding site [nucleotide binding]; other site 1042403004304 putative cAMP binding site [chemical binding]; other site 1042403004305 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1042403004306 TM2 domain; Region: TM2; pfam05154 1042403004307 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1042403004308 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1042403004309 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1042403004310 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1042403004311 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1042403004312 lipoyl attachment site [posttranslational modification]; other site 1042403004313 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1042403004314 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1042403004315 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1042403004316 putative NADH binding site [chemical binding]; other site 1042403004317 putative active site [active] 1042403004318 nudix motif; other site 1042403004319 putative metal binding site [ion binding]; other site 1042403004320 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1042403004321 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1042403004322 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1042403004323 catalytic residues [active] 1042403004324 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1042403004325 G5 domain; Region: G5; pfam07501 1042403004326 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1042403004327 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1042403004328 catalytic residue [active] 1042403004329 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1042403004330 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1042403004331 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1042403004332 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 1042403004333 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1042403004334 Ligand binding site; other site 1042403004335 Putative Catalytic site; other site 1042403004336 DXD motif; other site 1042403004337 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1042403004338 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1042403004339 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1042403004340 substrate binding site; other site 1042403004341 tetramer interface; other site 1042403004342 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1042403004343 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1042403004344 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1042403004345 NADP binding site [chemical binding]; other site 1042403004346 active site 1042403004347 putative substrate binding site [chemical binding]; other site 1042403004348 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1042403004349 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1042403004350 NAD binding site [chemical binding]; other site 1042403004351 substrate binding site [chemical binding]; other site 1042403004352 homodimer interface [polypeptide binding]; other site 1042403004353 active site 1042403004354 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1042403004355 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1042403004356 Probable Catalytic site; other site 1042403004357 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1042403004358 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1042403004359 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1042403004360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1042403004361 active site 1042403004362 putative glycosyl transferase; Provisional; Region: PRK10073 1042403004363 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1042403004364 active site 1042403004365 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1042403004366 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1042403004367 active site 1042403004368 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1042403004369 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1042403004370 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1042403004371 active site 1042403004372 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1042403004373 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1042403004374 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1042403004375 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1042403004376 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1042403004377 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1042403004378 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 1042403004379 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1042403004380 active site 1042403004381 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1042403004382 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1042403004383 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1042403004384 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403004385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403004386 putative substrate translocation pore; other site 1042403004387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403004388 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 1042403004389 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1042403004390 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1042403004391 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 1042403004392 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 1042403004393 active site 1042403004394 multimer interface [polypeptide binding]; other site 1042403004395 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 1042403004396 predicted active site [active] 1042403004397 catalytic triad [active] 1042403004398 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1042403004399 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 1042403004400 putative NAD(P) binding site [chemical binding]; other site 1042403004401 active site 1042403004402 putative substrate binding site [chemical binding]; other site 1042403004403 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 1042403004404 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 1042403004405 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1042403004406 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1042403004407 active site 1042403004408 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 1042403004409 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 1042403004410 Ligand binding site; other site 1042403004411 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1042403004412 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1042403004413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403004414 Walker A/P-loop; other site 1042403004415 ATP binding site [chemical binding]; other site 1042403004416 Q-loop/lid; other site 1042403004417 ABC transporter signature motif; other site 1042403004418 Walker B; other site 1042403004419 D-loop; other site 1042403004420 H-loop/switch region; other site 1042403004421 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1042403004422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403004423 Walker A/P-loop; other site 1042403004424 ATP binding site [chemical binding]; other site 1042403004425 Q-loop/lid; other site 1042403004426 ABC transporter signature motif; other site 1042403004427 Walker B; other site 1042403004428 D-loop; other site 1042403004429 H-loop/switch region; other site 1042403004430 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1042403004431 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1042403004432 acyl-activating enzyme (AAE) consensus motif; other site 1042403004433 putative AMP binding site [chemical binding]; other site 1042403004434 putative active site [active] 1042403004435 putative CoA binding site [chemical binding]; other site 1042403004436 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 1042403004437 putative active site [active] 1042403004438 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1042403004439 dimer interface [polypeptide binding]; other site 1042403004440 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1042403004441 nudix motif; other site 1042403004442 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1042403004443 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1042403004444 active site 1042403004445 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1042403004446 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1042403004447 Chain length determinant protein; Region: Wzz; cl15801 1042403004448 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1042403004449 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1042403004450 Nucleotide binding site [chemical binding]; other site 1042403004451 DTAP/Switch II; other site 1042403004452 Switch I; other site 1042403004453 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1042403004454 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1042403004455 homoserine kinase; Provisional; Region: PRK01212 1042403004456 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1042403004457 homoserine dehydrogenase; Provisional; Region: PRK06349 1042403004458 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1042403004459 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1042403004460 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1042403004461 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1042403004462 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1042403004463 catalytic residue [active] 1042403004464 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1042403004465 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1042403004466 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 1042403004467 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1042403004468 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1042403004469 active site 1042403004470 HIGH motif; other site 1042403004471 KMSK motif region; other site 1042403004472 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1042403004473 tRNA binding surface [nucleotide binding]; other site 1042403004474 anticodon binding site; other site 1042403004475 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1042403004476 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1042403004477 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1042403004478 homotrimer interaction site [polypeptide binding]; other site 1042403004479 putative active site [active] 1042403004480 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1042403004481 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004482 dimer interface [polypeptide binding]; other site 1042403004483 conserved gate region; other site 1042403004484 putative PBP binding loops; other site 1042403004485 ABC-ATPase subunit interface; other site 1042403004486 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1042403004487 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1042403004488 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1042403004489 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1042403004490 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1042403004491 hypothetical protein; Provisional; Region: PRK03298 1042403004492 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1042403004493 gamma subunit interface [polypeptide binding]; other site 1042403004494 epsilon subunit interface [polypeptide binding]; other site 1042403004495 LBP interface [polypeptide binding]; other site 1042403004496 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1042403004497 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1042403004498 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1042403004499 alpha subunit interaction interface [polypeptide binding]; other site 1042403004500 Walker A motif; other site 1042403004501 ATP binding site [chemical binding]; other site 1042403004502 Walker B motif; other site 1042403004503 inhibitor binding site; inhibition site 1042403004504 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1042403004505 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1042403004506 core domain interface [polypeptide binding]; other site 1042403004507 delta subunit interface [polypeptide binding]; other site 1042403004508 epsilon subunit interface [polypeptide binding]; other site 1042403004509 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1042403004510 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1042403004511 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1042403004512 beta subunit interaction interface [polypeptide binding]; other site 1042403004513 Walker A motif; other site 1042403004514 ATP binding site [chemical binding]; other site 1042403004515 Walker B motif; other site 1042403004516 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1042403004517 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1042403004518 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1042403004519 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1042403004520 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1042403004521 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1042403004522 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1042403004523 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1042403004524 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1042403004525 proposed active site lysine [active] 1042403004526 conserved cys residue [active] 1042403004527 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403004528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403004529 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1042403004530 active site 1042403004531 tetramer interface [polypeptide binding]; other site 1042403004532 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1042403004533 Plasmid replication protein; Region: Rep_2; pfam01719 1042403004534 Protein of unknown function DUF262; Region: DUF262; pfam03235 1042403004535 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1042403004536 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1042403004537 active site 1042403004538 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 1042403004539 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1042403004540 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1042403004541 Int/Topo IB signature motif; other site 1042403004542 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1042403004543 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1042403004544 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1042403004545 Cellulose or protein binding domain; Region: CBM_10; pfam02013 1042403004546 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1042403004547 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1042403004548 PYR/PP interface [polypeptide binding]; other site 1042403004549 dimer interface [polypeptide binding]; other site 1042403004550 TPP binding site [chemical binding]; other site 1042403004551 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1042403004552 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1042403004553 TPP-binding site; other site 1042403004554 dimer interface [polypeptide binding]; other site 1042403004555 Voltage gated chloride channel; Region: Voltage_CLC; pfam00654 1042403004556 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1042403004557 Cl- selectivity filter; other site 1042403004558 Cl- binding residues [ion binding]; other site 1042403004559 pore gating glutamate residue; other site 1042403004560 dimer interface [polypeptide binding]; other site 1042403004561 TQXA domain; Region: TQXA_dom; TIGR03934 1042403004562 Cna protein B-type domain; Region: Cna_B; pfam05738 1042403004563 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 1042403004564 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1042403004565 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1042403004566 active site 1042403004567 catalytic site [active] 1042403004568 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1042403004569 dimer interface [polypeptide binding]; other site 1042403004570 substrate binding site [chemical binding]; other site 1042403004571 metal binding sites [ion binding]; metal-binding site 1042403004572 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1042403004573 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1042403004574 DNA binding site [nucleotide binding] 1042403004575 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1042403004576 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1042403004577 minor groove reading motif; other site 1042403004578 helix-hairpin-helix signature motif; other site 1042403004579 substrate binding pocket [chemical binding]; other site 1042403004580 active site 1042403004581 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1042403004582 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1042403004583 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1042403004584 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1042403004585 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1042403004586 active site 1042403004587 HIGH motif; other site 1042403004588 nucleotide binding site [chemical binding]; other site 1042403004589 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1042403004590 active site 1042403004591 KMSKS motif; other site 1042403004592 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1042403004593 tRNA binding surface [nucleotide binding]; other site 1042403004594 anticodon binding site; other site 1042403004595 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 1042403004596 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1042403004597 dimerization interface [polypeptide binding]; other site 1042403004598 putative Zn2+ binding site [ion binding]; other site 1042403004599 putative DNA binding site [nucleotide binding]; other site 1042403004600 chorismate mutase; Provisional; Region: PRK09239 1042403004601 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1042403004602 transcription termination factor Rho; Provisional; Region: PRK12608 1042403004603 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1042403004604 RNA binding site [nucleotide binding]; other site 1042403004605 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1042403004606 Walker A motif; other site 1042403004607 ATP binding site [chemical binding]; other site 1042403004608 Walker B motif; other site 1042403004609 hypothetical protein; Provisional; Region: PRK07208 1042403004610 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1042403004611 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1042403004612 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1042403004613 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1042403004614 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1042403004615 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1042403004616 GatB domain; Region: GatB_Yqey; pfam02637 1042403004617 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1042403004618 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1042403004619 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1042403004620 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1042403004621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403004622 ABC transporter signature motif; other site 1042403004623 Walker B; other site 1042403004624 D-loop; other site 1042403004625 H-loop/switch region; other site 1042403004626 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1042403004627 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 1042403004628 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1042403004629 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1042403004630 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1042403004631 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1042403004632 Clp amino terminal domain; Region: Clp_N; pfam02861 1042403004633 Clp amino terminal domain; Region: Clp_N; pfam02861 1042403004634 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403004635 Walker A motif; other site 1042403004636 ATP binding site [chemical binding]; other site 1042403004637 Walker B motif; other site 1042403004638 arginine finger; other site 1042403004639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1042403004640 Walker A motif; other site 1042403004641 ATP binding site [chemical binding]; other site 1042403004642 Walker B motif; other site 1042403004643 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1042403004644 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1042403004645 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 1042403004646 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1042403004647 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1042403004648 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 1042403004649 metal ion-dependent adhesion site (MIDAS); other site 1042403004650 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1042403004651 active site 1042403004652 catalytic site [active] 1042403004653 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1042403004654 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1042403004655 catalytic residue [active] 1042403004656 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1042403004657 active site 1042403004658 HIGH motif; other site 1042403004659 nucleotide binding site [chemical binding]; other site 1042403004660 active site 1042403004661 KMSKS motif; other site 1042403004662 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 1042403004663 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1042403004664 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1042403004665 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1042403004666 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1042403004667 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1042403004668 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1042403004669 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1042403004670 dimer interface [polypeptide binding]; other site 1042403004671 ssDNA binding site [nucleotide binding]; other site 1042403004672 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1042403004673 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1042403004674 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1042403004675 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1042403004676 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1042403004677 active site 1042403004678 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1042403004679 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1042403004680 substrate binding site [chemical binding]; other site 1042403004681 dimer interface [polypeptide binding]; other site 1042403004682 ATP binding site [chemical binding]; other site 1042403004683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1042403004684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1042403004685 putative substrate translocation pore; other site 1042403004686 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1042403004687 active site 1042403004688 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403004689 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403004690 DNA binding site [nucleotide binding] 1042403004691 domain linker motif; other site 1042403004692 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1042403004693 dimerization interface [polypeptide binding]; other site 1042403004694 ligand binding site [chemical binding]; other site 1042403004695 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1042403004696 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1042403004697 UDP-galactopyranose mutase; Region: GLF; pfam03275 1042403004698 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1042403004699 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1042403004700 active site 1042403004701 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1042403004702 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1042403004703 active site 1042403004704 Sulfatase; Region: Sulfatase; pfam00884 1042403004705 Sulfatase; Region: Sulfatase; pfam00884 1042403004706 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1042403004707 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1042403004708 active site 1042403004709 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1042403004710 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1042403004711 active site 1042403004712 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 1042403004713 active site 1042403004714 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1042403004715 S-layer homology domain; Region: SLH; pfam00395 1042403004716 S-layer homology domain; Region: SLH; pfam00395 1042403004717 S-layer homology domain; Region: SLH; pfam00395 1042403004718 MULE transposase domain; Region: MULE; pfam10551 1042403004719 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 1042403004720 Leucine rich repeat; Region: LRR_8; pfam13855 1042403004721 S-layer homology domain; Region: SLH; pfam00395 1042403004722 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1042403004723 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1042403004724 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1042403004725 Walker A/P-loop; other site 1042403004726 ATP binding site [chemical binding]; other site 1042403004727 Q-loop/lid; other site 1042403004728 ABC transporter signature motif; other site 1042403004729 Walker B; other site 1042403004730 D-loop; other site 1042403004731 H-loop/switch region; other site 1042403004732 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1042403004733 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1042403004734 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1042403004735 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1042403004736 active site 1042403004737 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 1042403004738 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1042403004739 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1042403004740 FtsX-like permease family; Region: FtsX; pfam02687 1042403004741 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1042403004742 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403004743 ATP binding site [chemical binding]; other site 1042403004744 Q-loop/lid; other site 1042403004745 ABC transporter signature motif; other site 1042403004746 Walker B; other site 1042403004747 D-loop; other site 1042403004748 H-loop/switch region; other site 1042403004749 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1042403004750 Zn2+ binding site [ion binding]; other site 1042403004751 Mg2+ binding site [ion binding]; other site 1042403004752 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1042403004753 putative active site [active] 1042403004754 putative dimer interface [polypeptide binding]; other site 1042403004755 YL1 nuclear protein; Region: YL1; pfam05764 1042403004756 K+ potassium transporter; Region: K_trans; pfam02705 1042403004757 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1042403004758 active site 1042403004759 Melibiase; Region: Melibiase; pfam02065 1042403004760 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1042403004761 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1042403004762 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1042403004763 Walker A/P-loop; other site 1042403004764 ATP binding site [chemical binding]; other site 1042403004765 Q-loop/lid; other site 1042403004766 ABC transporter signature motif; other site 1042403004767 Walker B; other site 1042403004768 D-loop; other site 1042403004769 H-loop/switch region; other site 1042403004770 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1042403004771 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1042403004772 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1042403004773 Walker A/P-loop; other site 1042403004774 ATP binding site [chemical binding]; other site 1042403004775 Q-loop/lid; other site 1042403004776 ABC transporter signature motif; other site 1042403004777 Walker B; other site 1042403004778 D-loop; other site 1042403004779 H-loop/switch region; other site 1042403004780 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1042403004781 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1042403004782 active site 1042403004783 HIGH motif; other site 1042403004784 KMSKS motif; other site 1042403004785 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1042403004786 tRNA binding surface [nucleotide binding]; other site 1042403004787 anticodon binding site; other site 1042403004788 Predicted methyltransferases [General function prediction only]; Region: COG0313 1042403004789 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1042403004790 putative SAM binding site [chemical binding]; other site 1042403004791 putative homodimer interface [polypeptide binding]; other site 1042403004792 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1042403004793 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1042403004794 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1042403004795 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1042403004796 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1042403004797 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1042403004798 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1042403004799 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1042403004800 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1042403004801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1042403004802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1042403004803 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1042403004804 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 1042403004805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403004806 motif II; other site 1042403004807 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1042403004808 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1042403004809 DNA binding residues [nucleotide binding] 1042403004810 putative dimer interface [polypeptide binding]; other site 1042403004811 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1042403004812 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1042403004813 HSP70 interaction site [polypeptide binding]; other site 1042403004814 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1042403004815 substrate binding site [polypeptide binding]; other site 1042403004816 dimer interface [polypeptide binding]; other site 1042403004817 GrpE; Region: GrpE; pfam01025 1042403004818 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1042403004819 dimer interface [polypeptide binding]; other site 1042403004820 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1042403004821 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1042403004822 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1042403004823 nucleotide binding site [chemical binding]; other site 1042403004824 NEF interaction site [polypeptide binding]; other site 1042403004825 SBD interface [polypeptide binding]; other site 1042403004826 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403004827 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403004828 DNA binding site [nucleotide binding] 1042403004829 domain linker motif; other site 1042403004830 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1042403004831 ligand binding site [chemical binding]; other site 1042403004832 dimerization interface [polypeptide binding]; other site 1042403004833 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1042403004834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403004835 motif II; other site 1042403004836 pullulanase, type I; Region: pulA_typeI; TIGR02104 1042403004837 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1042403004838 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1042403004839 Ca binding site [ion binding]; other site 1042403004840 active site 1042403004841 catalytic site [active] 1042403004842 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1042403004843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004844 dimer interface [polypeptide binding]; other site 1042403004845 conserved gate region; other site 1042403004846 putative PBP binding loops; other site 1042403004847 ABC-ATPase subunit interface; other site 1042403004848 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1042403004849 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004850 dimer interface [polypeptide binding]; other site 1042403004851 conserved gate region; other site 1042403004852 putative PBP binding loops; other site 1042403004853 ABC-ATPase subunit interface; other site 1042403004854 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1042403004855 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1042403004856 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1042403004857 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1042403004858 active site 1042403004859 catalytic site [active] 1042403004860 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1042403004861 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 1042403004862 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1042403004863 Protein of unknown function, DUF624; Region: DUF624; cl02369 1042403004864 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1042403004865 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004866 dimer interface [polypeptide binding]; other site 1042403004867 conserved gate region; other site 1042403004868 putative PBP binding loops; other site 1042403004869 ABC-ATPase subunit interface; other site 1042403004870 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1042403004871 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004872 dimer interface [polypeptide binding]; other site 1042403004873 conserved gate region; other site 1042403004874 putative PBP binding loops; other site 1042403004875 ABC-ATPase subunit interface; other site 1042403004876 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403004877 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403004878 DNA binding site [nucleotide binding] 1042403004879 domain linker motif; other site 1042403004880 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1042403004881 ligand binding site [chemical binding]; other site 1042403004882 dimerization interface [polypeptide binding]; other site 1042403004883 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1042403004884 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1042403004885 active site 1042403004886 catalytic site [active] 1042403004887 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 1042403004888 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403004889 catalytic core [active] 1042403004890 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1042403004891 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1042403004892 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1042403004893 dimer interface [polypeptide binding]; other site 1042403004894 FMN binding site [chemical binding]; other site 1042403004895 NADPH bind site [chemical binding]; other site 1042403004896 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1042403004897 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1042403004898 active site 1042403004899 catalytic triad [active] 1042403004900 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1042403004901 dimer interface [polypeptide binding]; other site 1042403004902 RelB antitoxin; Region: RelB; cl01171 1042403004903 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1042403004904 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1042403004905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1042403004906 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1042403004907 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1042403004908 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1042403004909 DNA binding site [nucleotide binding] 1042403004910 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1042403004911 dimerization interface [polypeptide binding]; other site 1042403004912 ligand binding site [chemical binding]; other site 1042403004913 NAD-dependent deacetylase; Provisional; Region: PRK00481 1042403004914 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1042403004915 threonine dehydratase; Provisional; Region: PRK08198 1042403004916 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1042403004917 tetramer interface [polypeptide binding]; other site 1042403004918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1042403004919 catalytic residue [active] 1042403004920 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1042403004921 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1042403004922 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1042403004923 Ca binding site [ion binding]; other site 1042403004924 active site 1042403004925 catalytic site [active] 1042403004926 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1042403004927 Raffinose synthase or seed inhibition protein Sip1; Region: Raffinose_syn; pfam05691 1042403004928 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1042403004929 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004930 dimer interface [polypeptide binding]; other site 1042403004931 conserved gate region; other site 1042403004932 putative PBP binding loops; other site 1042403004933 ABC-ATPase subunit interface; other site 1042403004934 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1042403004935 dimer interface [polypeptide binding]; other site 1042403004936 conserved gate region; other site 1042403004937 putative PBP binding loops; other site 1042403004938 ABC-ATPase subunit interface; other site 1042403004939 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1042403004940 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1042403004941 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1042403004942 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1042403004943 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 1042403004944 Melibiase; Region: Melibiase; pfam02065 1042403004945 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1042403004946 nucleoside/Zn binding site; other site 1042403004947 dimer interface [polypeptide binding]; other site 1042403004948 catalytic motif [active] 1042403004949 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1042403004950 Predicted esterase [General function prediction only]; Region: COG0400 1042403004951 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1042403004952 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 1042403004953 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1042403004954 trimer interface [polypeptide binding]; other site 1042403004955 active site 1042403004956 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1042403004957 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1042403004958 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1042403004959 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1042403004960 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1042403004961 motif II; other site 1042403004962 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1042403004963 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1042403004964 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1042403004965 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1042403004966 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 1042403004967 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1042403004968 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1042403004969 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1042403004970 Walker A/P-loop; other site 1042403004971 ATP binding site [chemical binding]; other site 1042403004972 Q-loop/lid; other site 1042403004973 ABC transporter signature motif; other site 1042403004974 Walker B; other site 1042403004975 D-loop; other site 1042403004976 H-loop/switch region; other site 1042403004977 TOBE domain; Region: TOBE_2; pfam08402 1042403004978 Ion transport protein; Region: Ion_trans; pfam00520 1042403004979 Ion channel; Region: Ion_trans_2; pfam07885 1042403004980 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1042403004981 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1042403004982 active site 1042403004983 ATP binding site [chemical binding]; other site 1042403004984 substrate binding site [chemical binding]; other site 1042403004985 activation loop (A-loop); other site 1042403004986 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1042403004987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1042403004988 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1042403004989 G5 domain; Region: G5; pfam07501 1042403004990 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1042403004991 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1042403004992 catalytic residue [active] 1042403004993 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1042403004994 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1042403004995 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 1042403004996 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1042403004997 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1042403004998 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1042403004999 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1042403005000 active site 1042403005001 NTP binding site [chemical binding]; other site 1042403005002 metal binding triad [ion binding]; metal-binding site 1042403005003 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1042403005004 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1042403005005 Zn2+ binding site [ion binding]; other site 1042403005006 Mg2+ binding site [ion binding]; other site 1042403005007 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1042403005008 active site 1042403005009 Ap6A binding site [chemical binding]; other site 1042403005010 nudix motif; other site 1042403005011 metal binding site [ion binding]; metal-binding site 1042403005012 integral membrane protein MviN; Region: mviN; TIGR01695 1042403005013 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1042403005014 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1042403005015 ParB-like nuclease domain; Region: ParB; smart00470 1042403005016 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1042403005017 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1042403005018 P-loop; other site 1042403005019 Magnesium ion binding site [ion binding]; other site 1042403005020 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1042403005021 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1042403005022 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1042403005023 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1042403005024 G-X-X-G motif; other site 1042403005025 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1042403005026 RxxxH motif; other site 1042403005027 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1042403005028 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 1042403005029 IncFII RepA protein family; Region: IncFII_repA; cl11495 1042403005030 hypothetical protein; Provisional; Region: PRK14372 1042403005031 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1042403005032 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399