-- dump date   	20140619_002140
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_002969028.1	COG0593 ATPase involved in DNA replicationinitiation
YP_002969029.1	binds the polymerase to DNA and acts as a sliding clamp
YP_002969030.1	COG1195 Recombinational DNA repair ATPase (RecF pathway)
YP_002969031.1	COG5512 Zn-ribbon-containing, possibly RNA-binding protein and truncated derivatives
YP_002969032.1	negatively supercoils closed circular double-stranded DNA
YP_002969033.1	negatively supercoils closed circular double-stranded DNA
YP_002969035.1	COG4767 Glycopeptide antibiotics resistance protein
YP_002969036.1	COG1272 Predicted membrane protein, hemolysin III homolog
YP_002969037.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_002969038.1	COG0477 Permeases of the major facilitator superfamily
YP_002969041.1	COG1970 Large-conductance mechanosensitive channel
YP_002969042.1	COG2308 Uncharacterized conserved protein
YP_002969043.1	COG1451 Predicted metal-dependent hydrolase
YP_002969045.1	COG2865 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen
YP_002969047.1	COG0178 Excinuclease ATPase subunit
YP_002969048.1	COG0500 SAM-dependent methyltransferases
YP_002969050.1	COG0431 Predicted flavoprotein
YP_002969052.1	COG1198 Primosomal protein N (replication factor Y - superfamily II helicase)
YP_002969055.1	COG1694 Predicted pyrophosphatase
YP_002969059.1	COG0270 Site-specific DNA methylase
YP_002969067.1	COG3041 Uncharacterized protein conserved in bacteria
YP_002969069.1	COG2336 Growth regulator
YP_002969070.1	COG2337 Growth inhibitor
YP_002969071.1	COG0583 Transcriptional regulator
YP_002969072.1	COG0656 Aldo/keto reductases, related to diketogulonate reductase
YP_002969073.1	COG0656 Aldo/keto reductases, related to diketogulonate reductase
YP_002969074.1	COG1472 Beta-glucosidase-related glycosidases
YP_002969076.1	COG3464 Transposase and inactivated derivatives
YP_002969077.1	COG5520 O-Glycosyl hydrolase
YP_002969078.1	COG1874 Beta-galactosidase
YP_002969079.1	COG0477 Permeases of the major facilitator superfamily
YP_002969080.1	COG1309 Transcriptional regulator
YP_002969081.1	COG0783 DNA-binding ferritin-like protein (oxidative damage protectant)
YP_002969082.1	COG1253 Hemolysins and related proteins containing CBS domains
YP_002969083.1	COG0288 Carbonic anhydrase
YP_002969084.1	COG1609 Transcriptional regulators
YP_002969086.1	COG4214 ABC-type xylose transport system, permease component
YP_002969087.1	COG1129 ABC-type sugar transport system, ATPase component
YP_002969089.1	COG1609 Transcriptional regulators
YP_002969090.1	COG3534 Alpha-L-arabinofuranosidase
YP_002969091.1	COG1070 Sugar (pentulose and hexulose kinases)
YP_002969092.1	catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate
YP_002969093.1	catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism
YP_002969094.1	COG0656 Aldo/keto reductases, related to diketogulonate reductase
YP_002969095.1	COG2352 Phosphoenolpyruvate carboxylase
YP_002969096.1	COG2966 Uncharacterized conserved protein
YP_002969097.1	COG3464 Transposase and inactivated derivatives
YP_002969098.1	COG0180 Tryptophanyl-tRNA synthetase
YP_002969101.1	COG0058 Glucan phosphorylase
YP_002969103.1	COG0705 Uncharacterized membrane protein (homolog of Drosophila rhomboid)
YP_002969104.1	COG0500 SAM-dependent methyltransferases
YP_002969105.1	integral membrane protein involved in inhibition of the Z-ring formation
YP_002969106.1	COG3879 Uncharacterized protein conserved in bacteria
YP_002969107.1	COG3764 Sortase (surface protein transpeptidase)
YP_002969108.1	COG0512 Anthranilate/para-aminobenzoate synthases component II
YP_002969109.1	COG0515 Serine/threonine protein kinase
YP_002969110.1	COG0515 Serine/threonine protein kinase
YP_002969111.1	COG0768 Cell division proteinFtsI/penicillin-binding protein 2
YP_002969112.1	COG0772 Bacterial cell division membrane protein
YP_002969113.1	COG0631 Serine/threonine protein phosphatase
YP_002969114.1	COG1716 FOG: FHA domain
YP_002969115.1	COG1716 FOG: FHA domain
YP_002969116.1	COG1506 Dipeptidylaminopeptidases/acylaminoacyl-peptidases
YP_002969117.1	COG0697 Permeases of the drug/metabolite transporter (DMT superfamily)
YP_002969118.1	COG2267 Lysophospholipase
YP_002969120.1	COG0500 SAM-dependent methyltransferases
YP_002969121.1	COG2261 Predicted membrane protein
YP_002969122.1	COG2261 Predicted membrane protein
YP_002969123.1	COG0493 NADPH-dependent glutamate synthase betachain and related oxidoreductases
YP_002969124.1	COG2217 Cation transport ATPase
YP_002969125.1	COG0265 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain
YP_002969126.1	COG1011 Predicted hydrolase (HAD superfamily)
YP_002969127.1	COG0790 FOG: TPR repeat, SEL1 subfamily
YP_002969128.1	COG0343 Queuine/archaeosine tRNA-ribosyltransferase
YP_002969129.1	putative metalloprotease
YP_002969131.1	COG2135 Uncharacterized conserved protein
YP_002969132.1	COG2814 Arabinose efflux permease
YP_002969134.1	COG3077 DNA-damage-inducible protein J
YP_002969135.1	COG0350 Methylated DNA-protein cysteinemethyltransferase
YP_002969137.1	COG0599 Uncharacterized homolog ofgamma-carboxymuconolactone decarboxylase subunit
YP_002969138.1	COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain
YP_002969139.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002969140.1	COG0583 Transcriptional regulator
YP_002969141.1	COG0667 Predicted oxidoreductases (related toaryl-alcohol dehydrogenases)
YP_002969143.1	COG4097 Predicted ferric reductase
YP_002969144.1	COG0716 Flavodoxins
YP_002969145.1	COG0789 Predicted transcriptional regulators
YP_002969146.1	COG0716 Flavodoxins
YP_002969147.1	COG0702 Predicted nucleoside-diphosphate-sugare pimerases
YP_002969148.1	COG1063 Threonine dehydrogenase and related Zn-dependent dehydrogenases
YP_002969149.1	COG0583 Transcriptional regulator
YP_002969150.1	COG0726 Predicted xylanase/chitin deacetylase
YP_002969151.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_002969152.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_002969153.1	COG0239 Integral membrane protein possibly involved in chromosome condensation
YP_002969154.1	COG0239 Integral membrane protein possibly involved in chromosome condensation
YP_002969155.1	COG0559 Branched-chain amino acid ABC-typetransport system, permease components
YP_002969156.1	COG4177 ABC-type branched-chain amino acid transport system, permease component
YP_002969157.1	COG0411 ABC-type branched-chain amino acid transport systems, ATPase component
YP_002969158.1	COG0410 ABC-type branched-chain amino acid transport systems, ATPase component
YP_002969159.1	COG0683 ABC-type branched-chain amino acidtransport systems, periplasmic component
YP_002969160.1	COG1609 Transcriptional regulators
YP_002969161.1	COG0366 Glycosidases
YP_002969162.1	COG0477 Permeases of the major facilitator superfamily
YP_002969163.1	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
YP_002969164.1	COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit
YP_002969166.1	COG2211 Na+/melibiose symporter and related transporters
YP_002969167.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002969168.1	COG4453 Uncharacterized protein conserved in bacteria
YP_002969170.1	COG0477 Permeases of the major facilitator superfamily
YP_002969171.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_002969174.1	COG2723Beta-glucosidase/6-phospho-beta- glucosidase/beta-galactosidase
YP_002969176.1	COG1609 Transcriptional regulators
YP_002969180.1	COG2942 N-acyl-D-glucosamine 2-epimerase
YP_002969181.1	COG4619 ABC-type uncharacterized transport system, ATPase component
YP_002969182.1	COG0390 ABC-type uncharacterized transport system, permease component
YP_002969183.1	COG1113 Gamma-aminobutyrate permease and related permeases
YP_002969184.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002969185.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002969186.1	COG1113 Gamma-aminobutyrate permease and related permeases
YP_002969187.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002969189.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002969190.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002969191.1	COG1846 Transcriptional regulators
YP_002969192.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002969193.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002969194.1	COG0726 Predicted xylanase/chitin deacetylase
YP_002969195.1	COG0671 Membrane-associated phospholipidphosphatase
YP_002969196.1	COG0110 Acetyltransferase (isoleucine patch superfamily)
YP_002969198.1	COG0683 ABC-type branched-chain amino acid transport systems, periplasmic component
YP_002969199.1	COG1309 Transcriptional regulator
YP_002969200.1	COG1511 Predicted membrane protein
YP_002969201.1	COG1511 Predicted membrane protein
YP_002969202.1	COG0477 Permeases of the major facilitator superfamily
YP_002969203.1	COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
YP_002969204.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002969205.1	COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
YP_002969206.1	COG4667 Predicted esterase of the alpha-beta hydrolase superfamily
YP_002969207.1	COG1309 Transcriptional regulator
YP_002969209.1	COG4690 Dipeptidase
YP_002969210.1	COG1309 Transcriptional regulator
YP_002969211.1	COG0552 Signal recognition particle GTPase
YP_002969212.1	COG0004 Ammonia permease
YP_002969213.1	COG0347 Nitrogen regulatory protein PII
YP_002969214.1	COG2844 UTP:GlnB (protein PII uridylyl transferase)
YP_002969215.1	COG1476 Predicted transcriptional regulators
YP_002969216.1	COG0305 Replicative DNA helicase
YP_002969217.1	COG0769 UDP-N-acetylmuramyl tripeptide synthase
YP_002969218.1	COG3442 Predicted glutamine amidotransferase
YP_002969219.1	COG3937 Uncharacterized conserved protein
YP_002969220.1	COG0661 Predicted unusual protein kinase
YP_002969221.1	COG0584 Glycerophosphoryl diesterphosphodiesterase
YP_002969222.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_002969224.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_002969225.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_002969227.1	COG4962 Flp pilus assembly protein, ATPase CpaF
YP_002969228.1	COG4965 Flp pilus assembly protein TadB
YP_002969233.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_002969234.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_002969235.1	COG0527 Aspartokinases
YP_002969236.1	COG0527 Aspartokinases
YP_002969237.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_002969239.1	COG0119 Isopropylmalate/homocitrate/citramalatesynthases
YP_002969240.1	COG0744 Membrane carboxypeptidase (penicillin-binding protein)
YP_002969241.1	COG1260 Myo-inositol-1-phosphate synthase
YP_002969243.1	COG0550 Topoisomerase IA
YP_002969244.1	COG0125 Thymidylate kinase
YP_002969245.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_002969246.1	COG1881 Phospholipid-binding protein
YP_002969247.1	COG4690 Dipeptidase
YP_002969248.1	COG4690 Dipeptidase
YP_002969249.1	COG1373 Predicted ATPase (AAA+ superfamily)
YP_002969250.1	COG2759 Formyltetrahydrofolate synthetase
YP_002969251.1	COG1049 Aconitase B
YP_002969253.1	COG2246 Predicted membrane protein
YP_002969255.1	COG0406 Fructose-2,6-bisphosphatase
YP_002969256.1	COG0477 Permeases of the major facilitator superfamily
YP_002969257.1	COG3464 Transposase and inactivated derivatives
YP_002969258.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_002969259.1	COG1409 Predicted phosphohydrolases
YP_002969260.1	COG1414 Transcriptional regulator
YP_002969261.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_002969262.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_002969263.1	COG1522 Transcriptional regulators
YP_002969264.1	COG0446 Uncharacterized NAD (FAD-dependent dehydrogenases)
YP_002969265.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_002969266.1	COG0204 1-acyl-sn-glycerol-3-phosphateacyltransferase
YP_002969267.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_002969268.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_002969270.1	COG1266 Predicted metal-dependent membrane protease
YP_002969271.1	COG0668 Small-conductance mechanosensitive channel
YP_002969272.1	COG1309 Transcriptional regulator
YP_002969274.1	COG4905 Predicted membrane protein
YP_002969275.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_002969277.1	COG0457 FOG: TPR repeat
YP_002969278.1	COG0524 Sugar kinases, ribokinase family
YP_002969279.1	required for 70S ribosome assembly
YP_002969280.1	COG1200 RecG-like helicase
YP_002969283.1	COG0742 N6-adenine-specific methylase
YP_002969284.1	methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA
YP_002969285.1	COG0806 RimM protein, required for 16S rRNA processing
YP_002969286.1	COG1837 Predicted RNA-binding protein (contains KH domain)
YP_002969287.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_002969288.1	COG3250 Beta-galactosidase/beta-glucuronidase
YP_002969289.1	COG3568 Metal-dependent hydrolase
YP_002969290.1	COG0053 Predicted Co/Zn/Cd cation transporters
YP_002969291.1	COG0541 Signal recognition particle GTPase
YP_002969292.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_002969293.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_002969294.1	COG0518 GMP synthase - Glutamine amidotransferase domain
YP_002969295.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_002969296.1	acetolactate synthase large subunit; catalyzes the formation of 2-acetolactate from pyruvate
YP_002969297.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_002969298.1	some L32 proteins have zinc finger motifs consisting of CXXC while others do not
YP_002969299.1	COG1399 Predicted metal-binding, possibly nucleic acid-binding protein
YP_002969300.1	COG3599 Cell division initiation protein
YP_002969301.1	Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA
YP_002969303.1	COG0667 Predicted oxidoreductases (related to aryl-alcohol dehydrogenases)
YP_002969304.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate
YP_002969306.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_002969307.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_002969308.1	COG2348 Uncharacterized protein involved in methicillin resistance
YP_002969309.1	COG0679 Predicted permeases
YP_002969310.1	COG0836 Mannose-1-phosphate guanylyltransferase
YP_002969311.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_002969312.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_002969313.1	COG0681 Signal peptidase I
YP_002969314.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_002969315.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002969316.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002969317.1	COG0679 Predicted permeases
YP_002969318.1	catalyzes the formation of succinate and diaminoheptanedioate from succinyldiaminoheptanedioate
YP_002969319.1	COG1530 Ribonucleases G and E
YP_002969320.1	COG0261 Ribosomal protein L21
YP_002969321.1	involved in the peptidyltransferase reaction during translation
YP_002969322.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_002969323.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_002969324.1	catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate
YP_002969325.1	forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_002969326.1	COG0250 Transcription antiterminator
YP_002969327.1	binds directly to 23S ribosomal RNA
YP_002969328.1	in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA
YP_002969329.1	COG2508 Regulator of polyketide synthase expression
YP_002969330.1	COG0340 Biotin-(acetyl-CoA carboxylase ligase)
YP_002969331.1	COG1268 Uncharacterized conserved protein
YP_002969332.1	COG4770 Acetyl/propionyl-CoA carboxylase, alpha subunit
YP_002969333.1	COG4799 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)
YP_002969334.1	COG0331 (acyl-carrier-proteinS-malonyltransferase)
YP_002969335.1	COG0736 Phosphopantetheinyl transferase (holo-ACP synthase)
YP_002969337.1	COG0039 Malate/lactate dehydrogenases
YP_002969338.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_002969339.1	COG1185 Polyribonucleotide nucleotidyltransferase(polynucleotide phosphorylase)
YP_002969340.1	COG1704 Uncharacterized conserved protein
YP_002969341.1	COG4907 Predicted membrane protein
YP_002969342.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_002969343.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_002969344.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_002969345.1	COG0695 Glutaredoxin and related proteins
YP_002969346.1	COG0667 Predicted oxidoreductases (related toaryl-alcohol dehydrogenases)
YP_002969347.1	COG0826 Collagenase and related proteases
YP_002969348.1	COG1496 Uncharacterized conserved protein
YP_002969349.1	COG1211 4-diphosphocytidyl-2-methyl-D-erithritolsynthase
YP_002969350.1	COG2039 Pyrrolidone-carboxylate peptidase (N-terminal pyroglutamyl peptidase)
YP_002969351.1	COG3599 Cell division initiation protein
YP_002969352.1	COG3579 Aminopeptidase C
YP_002969353.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive
YP_002969354.1	COG1835 Predicted acyltransferases
YP_002969355.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_002969356.1	COG0775 Nucleoside phosphorylase
YP_002969357.1	COG0642 Signal transduction histidine kinase
YP_002969358.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_002969359.1	COG0226 ABC-type phosphate transport system, periplasmic component
YP_002969360.1	COG0573 ABC-type phosphate transport system, permease component
YP_002969361.1	COG0581 ABC-type phosphate transport system, permease component
YP_002969362.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_002969363.1	COG2252 Permeases
YP_002969364.1	COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
YP_002969365.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_002969366.1	present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors
YP_002969367.1	COG1716 FOG: FHA domain
YP_002969368.1	COG1112 Superfamily I DNA and RNA helicases and helicase subunits
YP_002969371.1	COG2331 Uncharacterized protein conserved in bacteria
YP_002969372.1	COG0212 5-formyltetrahydrofolate cyclo-ligase
YP_002969373.1	COG1670 Acetyltransferases, including N-acetylasesof ribosomal proteins
YP_002969375.1	10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring
YP_002969376.1	in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif
YP_002969377.1	COG0812 UDP-N-acetylmuramate dehydrogenase
YP_002969378.1	COG0531 Amino acid transporters
YP_002969379.1	COG1146 Ferredoxin
YP_002969380.1	catalyzes the formation of N-succinyl-LL-2,6-diaminopimelate from N-succinyl-L-2-amino-6-oxopimelate in lysine biosynthesis
YP_002969381.1	COG0389 Nucleotidyltransferase/DNA polymeraseinvolved in DNA repair
YP_002969382.1	COG0111 Phosphoglycerate dehydrogenase and related dehydrogenases
YP_002969383.1	COG1739 Uncharacterized conserved protein
YP_002969385.1	COG1640 4-alpha-glucanotransferase
YP_002969386.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_002969387.1	forms a direct contact with the tRNA during translation
YP_002969388.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
YP_002969389.1	COG1940 Transcriptional regulator/sugar kinase
YP_002969390.1	COG1012 NAD-dependent aldehyde dehydrogenases
YP_002969393.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_002969394.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_002969395.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_002969396.1	binds third domain of 23S rRNA and protein L29; part of exit tunnel
YP_002969397.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_002969398.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_002969399.2	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_002969400.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_002969401.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_002969402.1	COG0255 Ribosomal protein L29
YP_002969403.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_002969404.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_002969405.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_002969406.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_002969407.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group appear to contain the zinc-binding motif
YP_002969408.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_002969409.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_002969410.1	binds 5S rRNA along with protein L5 and L25
YP_002969411.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_002969412.1	COG1841 Ribosomal protein L30/L7E
YP_002969413.1	late assembly protein
YP_002969414.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_002969415.1	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_002969416.1	stimulates the activities of the other two initiation factors, IF-2 and IF-3
YP_002969417.1	smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif
YP_002969418.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_002969419.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_002969420.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_002969421.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_002969422.1	COG0101 Pseudouridylate synthase
YP_002969424.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_002969425.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_002969426.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_002969427.1	COG0130 Pseudouridine synthase
YP_002969428.1	COG0196 FAD synthase
YP_002969429.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_002969431.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_002969432.1	COG0328 Ribonuclease HI
YP_002969433.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002969434.1	COG1597 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase
YP_002969435.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_002969436.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002969438.1	COG0457 FOG: TPR repeat
YP_002969439.1	COG2197 Response regulator containing a CheY-likereceiver domain and an HTH DNA-binding domain
YP_002969440.1	COG1983 Putative stress-responsive transcriptional regulator
YP_002969441.1	COG1983 Putative stress-responsive transcriptional regulator
YP_002969443.1	COG0626 Cystathionine beta-lyases/cystathioninegamma-synthases
YP_002969444.1	COG2873 O-acetylhomoserine sulfhydrylase
YP_002969445.1	COG2873 O-acetylhomoserine sulfhydrylase
YP_002969446.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_002969450.1	COG3579 Aminopeptidase C
YP_002969451.1	COG0531 Amino acid transporters
YP_002969452.1	COG2939 Carboxypeptidase C (cathepsin A)
YP_002969453.1	COG0531 Amino acid transporters
YP_002969454.1	COG1575 1,4-dihydroxy-2-naphthoateoctaprenyl transferase
YP_002969455.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_002969456.1	in group A Streptococci this protein was found to cross react with anti myosin antibodies and may play a role in rheumatic fever
YP_002969457.1	COG1482 Phosphomannose isomerase
YP_002969458.1	COG0642 Signal transduction histidine kinase
YP_002969459.1	COG0704 Phosphate uptake regulator
YP_002969460.1	catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate
YP_002969461.1	COG3942 Surface antigen
YP_002969463.1	COG0791 Cell wall-associated hydrolases (invasion-associated proteins)
YP_002969464.1	COG0589 Universal stress protein UspA and related nucleotide-binding proteins
YP_002969465.1	COG1765 Predicted redox protein, regulator of disulfide bond formation
YP_002969466.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_002969467.1	COG0262 Dihydrofolate reductase
YP_002969468.1	COG0394 Protein-tyrosine-phosphatase
YP_002969469.1	COG1087 UDP-glucose 4-epimerase
YP_002969470.1	COG0220 Predicted S-adenosylmethionine-dependent methyltransferase
YP_002969471.1	COG1434 Uncharacterized conserved protein
YP_002969473.1	COG3642 Mn2+-dependent serine/threonine protein kinase
YP_002969474.1	COG3593 Predicted ATP-dependent endonuclease of the OLD family
YP_002969477.1	COG4487 Uncharacterized protein conserved in bacteria
YP_002969480.1	COG4913 Uncharacterized protein conserved in bacteria
YP_002969481.1	COG4924 Uncharacterized protein conserved in bacteria
YP_002969482.1	COG3189 Uncharacterized conserved protein
YP_002969483.1	COG2211 Na+/melibiose symporter and related transporters
YP_002969484.1	COG3250 Beta-galactosidase/beta-glucuronidase
YP_002969485.1	COG1609 Transcriptional regulators
YP_002969486.1	COG1011 Predicted hydrolase (HAD superfamily)
YP_002969491.1	COG1653 ABC-type sugar transport system, periplasmic component
YP_002969492.1	COG1874 Beta-galactosidase
YP_002969493.1	COG0395 ABC-type sugar transport system, permease component
YP_002969494.1	COG1175 ABC-type sugar transport systems, permease components
YP_002969495.1	COG1609 Transcriptional regulators
YP_002969496.1	COG0463 Glycosyl transferases involved in cell wall biogenesis
YP_002969497.1	COG0628 Predicted permease
YP_002969498.1	COG1215 Glycosyltransferases, probably involved in cell wall biogenesis
YP_002969499.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002969501.1	COG2027 D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 4)
YP_002969502.1	COG0037 Predicted ATPase of the PP-loop superfamily implicated in cell cycle control
YP_002969503.1	COG0634 Hypoxanthine-guaninephosphoribosyltransferase
YP_002969504.1	COG0465 ATP-dependent Zn proteases
YP_002969507.1	COG1946 Acyl-CoA thioesterase
YP_002969508.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_002969509.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_002969510.1	COG2873 O-acetylhomoserine sulfhydrylase
YP_002969511.1	COG4721 Predicted membrane protein
YP_002969514.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_002969515.1	catalyzes the interconversion of D-xylose to D-xylulose
YP_002969516.1	COG3507 Beta-xylosidase
YP_002969517.1	COG1609 Transcriptional regulators
YP_002969518.1	COG1653 ABC-type sugar transport system, periplasmic component
YP_002969519.1	COG1175 ABC-type sugar transport systems, permease components
YP_002969520.1	COG0395 ABC-type sugar transport system, permease component
YP_002969521.1	COG3507 Beta-xylosidase
YP_002969523.1	COG2272 Carboxylesterase type B
YP_002969524.1	COG3507 Beta-xylosidase
YP_002969525.1	COG1070 Sugar (pentulose and hexulose kinases)
YP_002969526.1	COG1940 Transcriptional regulator/sugar kinase
YP_002969527.1	RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_002969528.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_002969529.1	COG2890 Methylase of polypeptide chain release factors
YP_002969530.1	COG0009 Putative translation factor (SUA5)
YP_002969531.1	COG0472 UDP-N-acetylmuramyl pentapeptidephosphotransferase/UDP-N-acetylglucosamine-1- phosphatetransferase
YP_002969532.1	COG0516 IMP dehydrogenase/GMP reductase
YP_002969533.1	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_002969534.1	COG0561 Predicted hydrolases of the HAD superfamily
YP_002969535.1	COG0507 ATP-dependent exoDNAse (exonuclease V, alpha subunit - helicase superfamily I member)
YP_002969537.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_002969538.1	COG0629 Single-stranded DNA-binding protein
YP_002969539.1	COG3590 Predicted metalloendopeptidase
YP_002969540.1	COG3247 Uncharacterized conserved protein
YP_002969541.1	COG0024 Methionine aminopeptidase
YP_002969542.1	COG0372 Citrate synthase
YP_002969543.1	SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_002969544.1	COG2171 TetrahydrodipicolinateN-succinyltransferase
YP_002969546.1	recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1
YP_002969547.1	COG2884 Predicted ATPase involved in cell division
YP_002969548.1	COG2177 Cell division protein
YP_002969549.1	COG3942 Surface antigen
YP_002969550.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_002969552.1	COG0834 ABC-type amino acid transport/signaltransduction systems, periplasmic component/domain
YP_002969553.1	COG0834 ABC-type amino acid transport/signaltransduction systems, periplasmic component/domain
YP_002969554.1	COG0765 ABC-type amino acid transport system, permease component
YP_002969555.1	COG1126 ABC-type polar amino acid transport system, ATPase component
YP_002969557.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
YP_002969558.1	Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_002969559.1	COG0564 Pseudouridylate synthases, 23SRNA-specific
YP_002969561.1	type III; catalyzes the formation of (R)-4'-phosphopantothenate from (R)-pantothenate in coenzyme A biosynthesis; type III pantothenate kinases are not subject to feedback inhibition from coenzyme A and have a high Km for ATP
YP_002969562.1	COG0747 ABC-type dipeptide transport system, periplasmic component
YP_002969563.1	COG0601 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002969564.1	COG1173 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002969565.1	COG4172 ABC-type uncharacterized transport system, duplicated ATPase component
YP_002969566.1	COG1123 ATPase components of various ABC-typetransport systems, contain duplicated ATPase
YP_002969567.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_002969568.1	COG0031 Cysteine synthase
YP_002969569.1	COG0514 Superfamily II DNA helicase
YP_002969570.1	COG2852 Uncharacterized protein conserved in bacteria
YP_002969571.1	COG1670 Acetyltransferases, including N-acetylases of ribosomal proteins
YP_002969577.1	COG0494 NTP pyrophosphohydrolases includingoxidative damage repair enzymes
YP_002969578.1	COG3886 Predicted HKD family nuclease
YP_002969579.1	COG3177 Uncharacterized conserved protein
YP_002969580.1	COG1479 Uncharacterized conserved protein
YP_002969581.1	COG3600 Uncharacterized phage-associated protein
YP_002969582.1	COG3654 Prophage maintenance system killer protein
YP_002969583.1	COG1247 Sortase and related acyltransferases
YP_002969584.1	COG3752 Predicted membrane protein
YP_002969585.1	COG0371 Glycerol dehydrogenase and related enzymes
YP_002969586.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_002969587.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002969588.1	COG0787 Alanine racemase
YP_002969589.1	synthesizes RNA primers at the replication forks
YP_002969590.1	COG0471 Di- and tricarboxylate transporters
YP_002969591.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_002969592.1	COG0041 Phosphoribosylcarboxyaminoimidazole (NCAIR mutase)
YP_002969593.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_002969594.1	COG0735 Fe2+/Zn2+ uptake regulation proteins
YP_002969595.1	COG2898 Uncharacterized conserved protein
YP_002969596.1	COG0627 Predicted esterase
YP_002969597.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_002969598.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_002969599.1	COG0034 Glutamine phosphoribosylpyrophosphateamidotransferase
YP_002969600.1	COG0389 Nucleotidyltransferase/DNA polymerase involved in DNA repair
YP_002969602.1	COG3597 Uncharacterized protein/domain associated with GTPases
YP_002969604.1	COG3467 Predicted flavin-nucleotide-binding protein
YP_002969605.1	COG1396 Predicted transcriptional regulators
YP_002969612.1	COG4260 Putative virion core protein (lumpy skin disease virus)
YP_002969613.1	COG0046 Phosphoribosylformylglycinamidine (FGAM synthase, synthetase domain)
YP_002969614.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_002969615.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_002969616.1	COG0438 Glycosyltransferase
YP_002969617.1	COG2008 Threonine aldolase
YP_002969619.2	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_002969620.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_002969621.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_002969622.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_002969624.1	COG0492 Thioredoxin reductase
YP_002969625.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_002969626.1	COG0781 Transcription termination factor
YP_002969627.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_002969628.1	COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ)
YP_002969629.1	COG0284 Orotidine-5-phosphate decarboxylase
YP_002969630.1	Essential for recycling GMP and indirectly, cGMP
YP_002969631.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_002969632.1	Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_002969633.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_002969634.1	COG2230 Cyclopropane fatty acid synthase and related methyltransferases
YP_002969635.1	binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_002969636.1	COG0223 Methionyl-tRNA formyltransferase
YP_002969637.1	COG0560 Phosphoserine phosphatase
YP_002969638.1	COG0586 Uncharacterized membrane-associated protein
YP_002969639.1	COG0464 ATPases of the AAA+ class
YP_002969641.1	COG0483 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family
YP_002969644.1	COG0776 Bacterial nucleoid DNA-binding protein
YP_002969645.1	COG0392 Predicted integral membrane protein
YP_002969646.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_002969647.1	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
YP_002969651.1	COG2304 Uncharacterized protein containing a vonWillebrand factor type A (vWA domain)
YP_002969653.1	COG1721 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWAdomain))
YP_002969654.1	COG0714 MoxR-like ATPases
YP_002969655.1	COG0692 Uracil DNA glycosylase
YP_002969657.1	COG1278 Cold shock proteins
YP_002969658.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_002969661.1	COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain
YP_002969662.1	COG0642 Signal transduction histidine kinase
YP_002969663.1	COG1278 Cold shock proteins
YP_002969666.1	COG0589 Universal stress protein UspA and related nucleotide-binding proteins
YP_002969667.1	COG0542 ATPases with chaperone activity, ATP-binding subunit
YP_002969668.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_002969669.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_002969671.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002969672.1	COG1126 ABC-type polar amino acid transport system, ATPase component
YP_002969673.1	COG0834 ABC-type amino acid transport/signaltransduction systems, periplasmic component/domain
YP_002969674.1	COG0765 ABC-type amino acid transport system, permease component
YP_002969675.1	COG0765 ABC-type amino acid transport system, permease component
YP_002969676.1	COG2326 Uncharacterized conserved protein
YP_002969677.1	COG4581 Superfamily II RNA helicase
YP_002969678.1	COG2256 ATPase related to the helicase subunit ofthe Holliday junction resolvase
YP_002969679.1	COG0477 Permeases of the major facilitator superfamily
YP_002969680.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
YP_002969681.1	COG3328 Transposase and inactivated derivatives
YP_002969683.1	COG4715 Uncharacterized conserved protein
YP_002969684.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002969685.1	COG3824 Uncharacterized protein conserved in bacteria
YP_002969686.1	COG3304 Predicted membrane protein
YP_002969687.1	COG0819 Putative transcription activator
YP_002969688.1	COG1534 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein
YP_002969689.1	COG0656 Aldo/keto reductases, related to diketogulonate reductase
YP_002969690.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002969691.1	COG3601 Predicted membrane protein
YP_002969692.1	COG1940 Transcriptional regulator/sugar kinase
YP_002969693.1	COG0436 Aspartate/tyrosine/aromatic aminotransferase
YP_002969694.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002969697.1	COG0272 NAD-dependent DNA ligase (contains BRCT domain type II)
YP_002969698.1	COG0489 ATPases involved in chromosome partitioning
YP_002969699.1	COG4721 Predicted membrane protein
YP_002969700.1	COG0174 Glutamine synthetase
YP_002969701.1	COG0532 Translation initiation factor 2 (IF-2; GTPase)
YP_002969702.1	COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3 component, and related enzymes)
YP_002969704.1	COG0624 Acetylornithinedeacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases
YP_002969705.1	COG4585 Signal transduction histidine kinase
YP_002969708.1	COG3409 Putative peptidoglycan-binding domain-containing protein
YP_002969710.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002969712.1	COG4721 Predicted membrane protein
YP_002969713.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002969714.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002969715.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002969717.1	COG0566 rRNA methylases
YP_002969718.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_002969719.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_002969721.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_002969722.1	bifunctional arginine biosynthesis protein ArgJ; functions at the 1st and 5th steps in arginine biosynthesis; involved in synthesis of acetylglutamate from glutamate and acetyl-CoA and ornithine by transacetylation between acetylornithine and glutmate
YP_002969723.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_002969724.1	catalyzes the formation of N-acetyl-l-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine
YP_002969725.1	catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation
YP_002969726.1	COG1438 Arginine repressor
YP_002969727.1	catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming
YP_002969728.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_002969729.1	COG1028 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
YP_002969730.1	COG1418 Predicted HD superfamily hydrolase
YP_002969731.1	COG0162 Tyrosyl-tRNA synthetase
YP_002969733.1	COG0647 Predicted sugar phosphatases of the HAD superfamily
YP_002969734.1	COG1189 Predicted rRNA methylase
YP_002969735.1	COG0168 Trk-type K+ transport systems, membrane components
YP_002969736.1	COG0569 K+ transport systems, NAD-binding component
YP_002969737.1	catalyzes the phosphorylation of NAD to NADP
YP_002969738.1	COG0497 ATPase involved in DNA repair
YP_002969739.1	COG0637 Predicted phosphatase/phosphohexomutase
YP_002969740.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_002969741.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_002969743.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_002969744.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_002969745.1	forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_002969746.1	COG0799 Uncharacterized homolog of plant Iojap protein
YP_002969747.1	COG0406 Fructose-2,6-bisphosphatase
YP_002969749.1	COG3576 Predicted flavin-nucleotide-binding protein structurally related to pyridoxine 5-phosphate oxidase
YP_002969750.1	COG0406 Fructose-2,6-bisphosphatase
YP_002969751.1	COG0598 Mg2+ and Co2+ transporters
YP_002969752.1	COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
YP_002969753.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_002969754.1	COG1555 DNA uptake protein and related DNA-binding proteins
YP_002969755.1	COG0658 Predicted membrane metal-binding protein
YP_002969756.1	COG1466 DNA polymerase III, delta subunit
YP_002969757.1	COG0802 Predicted ATPase or kinase
YP_002969758.1	COG1214 Inactive homolog of metal-dependent proteases, putative molecular chaperone
YP_002969759.1	COG0456 Acetyltransferases
YP_002969760.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_002969763.1	COG0739 Membrane proteins related to metalloendopeptidases
YP_002969764.1	COG4213 ABC-type xylose transport system, periplasmic component
YP_002969765.1	Converts isocitrate to alpha ketoglutarate
YP_002969766.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_002969768.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
YP_002969769.1	COG0242 N-formylmethionyl-tRNA deformylase
YP_002969770.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_002969771.1	EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu
YP_002969772.1	Catalyzes the phosphorylation of UMP to UDP
YP_002969773.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_002969774.1	COG0575 CDP-diglyceride synthetase
YP_002969775.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_002969776.1	COG1309 Transcriptional regulator
YP_002969777.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002969778.1	COG0842 ABC-type multidrug transport system, permease component
YP_002969779.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_002969780.1	PR-AMP cyclohydrolase; functions in histidine biosynthesis from PRPP; converts 1-(5-phosphoribosyl)-AMP to 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxyamide during the histidine biosynthesis pathway; binds zinc and magnesium; forms homodimers
YP_002969781.1	COG0147 Anthranilate/para-aminobenzoate synthases component I
YP_002969782.1	COG1573 Uracil-DNA glycosylase
YP_002969785.1	catalyzes ring closure to form indole-3-glycerol phosphate; catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_002969786.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_002969787.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_002969788.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_002969789.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribolsyl)-ATP in histidine biosynthesis
YP_002969790.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_002969791.1	COG0558 Phosphatidylglycerophosphate synthase
YP_002969792.1	COG3879 Uncharacterized protein conserved in bacteria
YP_002969793.1	COG3856 Uncharacterized conserved protein (small basic protein)
YP_002969794.1	COG3879 Uncharacterized protein conserved in bacteria
YP_002969795.1	COG1716 FOG: FHA domain
YP_002969796.1	COG0789 Predicted transcriptional regulators
YP_002969798.1	COG0239 Integral membrane protein possibly involved in chromosome condensation
YP_002969799.1	COG0239 Integral membrane protein possibly involved in chromosome condensation
YP_002969800.1	COG0546 Predicted phosphatases
YP_002969802.1	COG4581 Superfamily II RNA helicase
YP_002969804.1	COG2378 Predicted transcriptional regulator
YP_002969805.1	COG4284 UDP-glucose pyrophosphorylase
YP_002969806.1	CMK catalyzes the formation of (d)CDP from ATP and (d)CMP; the function of the GTP-binding domain EngA appears to be in synchronizing cellular events by interacting with multiple cellular targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide-binding affinities in the two binding domains
YP_002969807.1	COG1187 16S rRNA uridine-516 pseudo uridylatesynthase and related pseudouridylate synthases
YP_002969808.1	COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
YP_002969810.1	involved in de novo purine biosynthesis
YP_002969812.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_002969813.1	COG0045 Succinyl-CoA synthetase, beta subunit
YP_002969814.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_002969815.1	COG1862 Preprotein translocase subunit YajC
YP_002969816.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_002969817.1	COG0632 Holliday junction resolvasome, DNA-binding subunit
YP_002969818.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_002969819.1	COG0217 Uncharacterized conserved protein
YP_002969820.1	COG0438 Glycosyltransferase
YP_002969821.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_002969822.1	COG0558 Phosphatidylglycerophosphate synthase
YP_002969823.1	catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr)
YP_002969824.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_002969825.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002969829.1	phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_002969830.1	COG3001 Fructosamine-3-kinase
YP_002969831.1	COG0484 DnaJ-class molecular chaperone withC-terminal Zn finger domain
YP_002969832.1	Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons
YP_002969833.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_002969834.1	catalyzes the reversible formation of D-erythrose 4-phosphate and D-fructose 6-phosphate from sedoheptulose 7-phosphate and D-glyceraldehyde 3-phosphate
YP_002969835.1	COG1357 Uncharacterized low-complexity proteins
YP_002969836.1	COG0436 Aspartate/tyrosine/aromatic aminotransferase
YP_002969837.1	COG1522 Transcriptional regulators
YP_002969838.1	in Corynebacterium glutamicum the aminotransferase can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; this protein contains a helix-turn-helix domain at the N-terminus
YP_002969839.1	COG0561 Predicted hydrolases of the HAD superfamily
YP_002969841.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_002969842.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_002969843.1	COG1481 Uncharacterized protein conserved in bacteria
YP_002969844.1	COG1660 Predicted P-loop-containing kinase
YP_002969845.1	COG0169 Shikimate 5-dehydrogenase
YP_002969846.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_002969847.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_002969849.1	COG3663 G:T/U mismatch-specific DNA glycosylase
YP_002969850.1	COG0400 Predicted esterase
YP_002969851.1	COG0488 ATPase components of ABC transporters with duplicated ATPase domains
YP_002969852.1	COG0053 Predicted Co/Zn/Cd cation transporters
YP_002969853.1	COG0599 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit
YP_002969854.1	COG3049 Penicillin V acylase and related amidases
YP_002969855.1	COG0062 Uncharacterized conserved protein
YP_002969856.1	COG0450 Peroxiredoxin
YP_002969857.1	COG0492 Thioredoxin reductase
YP_002969858.1	COG0583 Transcriptional regulator
YP_002969859.1	COG1011 Predicted hydrolase (HAD superfamily)
YP_002969860.1	COG2852 Uncharacterized protein conserved in bacteria
YP_002969861.1	COG1397 ADP-ribosylglycohydrolase
YP_002969862.1	COG1733 Predicted transcriptional regulators
YP_002969864.1	COG0456 Acetyltransferases
YP_002969865.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_002969866.1	COG0167 Dihydroorotate dehydrogenase
YP_002969867.1	COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases
YP_002969868.1	COG0284 Orotidine-5-phosphate decarboxylase
YP_002969869.1	COG0044 Dihydroorotase and related cyclicamidohydrolases
YP_002969870.1	involved in the allosteric regulation of aspartate carbamoyltransferase
YP_002969871.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_002969873.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_002969874.1	COG0685 5,10-methylenetetrahydrofolate reductase
YP_002969875.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_002969876.1	COG2062 Phosphohistidine phosphatase SixA
YP_002969877.1	COG2519 tRNA (1-methyladenosine methyltransferase and related methyltransferases)
YP_002969878.1	COG1119 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA
YP_002969879.1	COG0438 Glycosyltransferase
YP_002969880.1	COG1225 Peroxiredoxin
YP_002969882.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_002969883.1	COG0067 Glutamate synthase domain 1
YP_002969884.1	COG0635 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases
YP_002969885.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_002969886.1	binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase
YP_002969887.1	COG2860 Predicted membrane protein
YP_002969888.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_002969889.1	the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response
YP_002969890.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002969891.1	COG1282 NAD/NADP transhydrogenase beta subunit
YP_002969892.1	COG3288 NAD/NADP transhydrogenase alpha subunit
YP_002969893.1	COG3288 NAD/NADP transhydrogenase alpha subunit
YP_002969894.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
YP_002969895.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_002969896.1	COG1253 Hemolysins and related proteins containing CBS domains
YP_002969897.1	COG0319 Predicted metal-dependent hydrolase
YP_002969898.1	COG1702 Phosphate starvation-inducible protein PhoH, predicted ATPase
YP_002969899.1	COG0537 Diadenosine tetraphosphate (Ap4A hydrolase and other HIT family hydrolases)
YP_002969900.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_002969901.1	COG0566 rRNA methylases
YP_002969903.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_002969904.1	COG2151 Predicted metal-sulfur cluster biosynthetic enzyme
YP_002969905.1	COG0822 NifU homolog involved in Fe-S cluster formation
YP_002969906.1	COG0520 Selenocysteine lyase
YP_002969907.1	COG0396 ABC-type transport system involved in Fe-Scluster assembly, ATPase component
YP_002969908.1	COG0719 ABC-type transport system involved in Fe-Scluster assembly, permease component
YP_002969909.1	COG0719 ABC-type transport system involved in Fe-Scluster assembly, permease component
YP_002969910.1	COG1376 Uncharacterized protein conserved in bacteria
YP_002969912.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_002969914.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
YP_002969923.1	catalyzes the formation of 3-dehydroshikimate from 3-dehydroquinate in chorismate biosynthesis
YP_002969924.1	catalyzes the formation of shikimate 3-phosphate from shikimate and the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_002969925.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_002969927.1	COG1559 Predicted periplasmic solute-binding protein
YP_002969928.1	COG0816 Predicted endonuclease involved inrecombination (possible Holliday junction resolvase in Mycoplasmas and B. subtilis)
YP_002969929.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002969932.1	COG0406 Fructose-2,6-bisphosphatase
YP_002969933.1	COG1950 Predicted membrane protein
YP_002969934.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_002969935.1	COG0210 Superfamily I DNA and RNA helicases
YP_002969936.1	Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine
YP_002969937.1	COG2233 Xanthine/uracil permeases
YP_002969939.1	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
YP_002969940.1	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
YP_002969942.1	COG0366 Glycosidases
YP_002969943.1	COG2071 Predicted glutamine amidotransferases
YP_002969944.1	COG3760 Uncharacterized conserved protein
YP_002969946.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002969947.1	COG1725 Predicted transcriptional regulators
YP_002969948.1	COG1396 Predicted transcriptional regulators
YP_002969949.1	COG1816 Adenosine deaminase
YP_002969951.1	COG1605 Chorismate mutase
YP_002969953.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002969954.1	COG0563 Adenylate kinase and related kinases
YP_002969955.1	COG1373 Predicted ATPase (AAA+ superfamily)
YP_002969957.1	COG0480 Translation elongation factors (GTPases)
YP_002969958.1	COG3039 Transposase and inactivated derivatives, IS5 family
YP_002969959.1	COG0107 Imidazoleglycerol-phosphate synthase
YP_002969960.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_002969961.1	COG3957 Phosphoketolase
YP_002969962.1	COG0857 BioD-like N-terminal domain of phosphotransacetylase
YP_002969963.1	COG0282 Acetate kinase
YP_002969964.1	catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_002969966.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
YP_002969967.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_002969968.1	COG0327 Uncharacterized conserved protein
YP_002969969.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_002969970.1	COG3707 Response regulator with putative antiterminator output domain
YP_002969971.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_002969972.1	COG0469 Pyruvate kinase
YP_002969973.1	COG0861 Membrane protein TerC, possibly involved in tellurium resistance
YP_002969974.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_002969975.1	COG0237 Dephospho-CoA kinase
YP_002969976.1	in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_002969977.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_002969978.1	COG0803 ABC-type metal ion transport system, periplasmic component/surface adhesin
YP_002969979.1	COG1121 ABC-type Mn/Zn transport systems, ATPase component
YP_002969980.1	COG1108 ABC-type Mn2+/Zn2+ transport systems, permease components
YP_002969981.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_002969982.1	COG1329 Transcriptional regulators, similar to M.xanthus CarD
YP_002969983.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_002969984.1	COG0745 Response regulators consisting of aCheY-like receiver domain and a winged-helix DNA-binding domain
YP_002969985.1	COG0642 Signal transduction histidine kinase
YP_002969986.1	COG1040 Predicted amidophosphoribosyltransferases
YP_002969987.1	COG0561 Predicted hydrolases of the HAD superfamily
YP_002969990.1	COG1216 Predicted glycosyltransferases
YP_002969991.1	COG1316 Transcriptional regulator
YP_002969992.1	COG1316 Transcriptional regulator
YP_002969993.1	COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
YP_002969995.1	COG3920 Signal transduction histidine kinase
YP_002969996.1	COG0330 Membrane protease subunits, stomatin/prohibitin homologs
YP_002969997.1	COG0782 Transcription elongation factor
YP_002969998.1	COG0545 FKBP-type peptidyl-prolyl cis-transisomerases 1
YP_002969999.1	COG1760 L-serine deaminase
YP_002970001.1	COG0248 Exopolyphosphatase
YP_002970002.1	COG1507 Uncharacterized conserved protein
YP_002970003.1	COG2919 Septum formation initiator
YP_002970004.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_002970005.1	COG0600 ABC-type nitrate/sulfonate/bicarbonatetransport system, permease component
YP_002970006.1	COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
YP_002970007.1	COG1116 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component
YP_002970008.1	COG1197 Transcription-repair coupling factor (superfamily II helicase)
YP_002970009.1	Enables the recycling of peptidyl-tRNAs produced at termination of translation
YP_002970010.1	COG1247 Sortase and related acyltransferases
YP_002970011.1	COG1615 Uncharacterized conserved protein
YP_002970012.1	COG1472 Beta-glucosidase-related glycosidases
YP_002970013.1	COG2879 Uncharacterized small protein
YP_002970014.1	COG1966 Carbon starvation protein, predicted membrane protein
YP_002970015.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002970016.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002970017.1	COG3910 Predicted ATPase
YP_002970019.1	COG1846 Transcriptional regulators
YP_002970021.1	catalyzes the formation of fumarate from aspartate
YP_002970022.1	COG1918 Fe2+ transport system protein A
YP_002970023.1	COG0370 Fe2+ transport system protein B
YP_002970025.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_002970026.1	COG3429 Glucose-6-P dehydrogenase subunit
YP_002970027.1	COG03636-phosphogluconolactonase/Glucosamine-6- phosphateisomerase/deaminase
YP_002970028.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_002970029.1	COG3340 Peptidase E
YP_002970030.1	COG1114 Branched-chain amino acid permeases
YP_002970031.1	COG0225 Peptide methionine sulfoxide reductase
YP_002970032.1	COG4633 Uncharacterized protein conserved in bacteria
YP_002970033.1	COG0300 Short-chain dehydrogenases of various substrate specificities
YP_002970034.1	COG0513 Superfamily II DNA and RNA helicases
YP_002970035.1	COG2855 Predicted membrane protein
YP_002970036.1	COG2233 Xanthine/uracil permeases
YP_002970037.1	COG0657 Esterase/lipase
YP_002970039.1	COG1917 Uncharacterized conserved protein, contains double-stranded beta-helix domain
YP_002970040.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_002970041.1	COG0345 Pyrroline-5-carboxylate reductase
YP_002970042.1	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
YP_002970043.1	COG4585 Signal transduction histidine kinase
YP_002970044.1	COG2197 Response regulator containing a CheY-likereceiver domain and an HTH DNA-binding domain
YP_002970045.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002970046.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002970047.1	COG0619 ABC-type cobalt transport system, permease component CbiQ and related transporters
YP_002970048.1	COG1122 ABC-type cobalt transport system, ATPase component
YP_002970050.1	COG2873 O-acetylhomoserine sulfhydrylase
YP_002970051.1	COG2240 Pyridoxal/pyridoxine/pyridoxamine kinase
YP_002970052.1	COG0792 Predicted endonuclease distantly related to archaeal Holliday junction resolvase
YP_002970053.1	COG0606 Predicted ATPase with chaperone activity
YP_002970054.1	COG0758 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake
YP_002970055.1	COG1053 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit
YP_002970056.1	COG0479 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit
YP_002970057.1	COG4122 Predicted O-methyltransferase
YP_002970058.1	COG1611 Predicted Rossmann fold nucleotide-binding protein
YP_002970059.1	COG3004 Na+/H+ antiporter
YP_002970060.1	COG1168 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities
YP_002970061.1	binds and unfolds substrates as part of the ClpXP protease
YP_002970062.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_002970063.1	COG0740 Protease subunit of ATP-dependent Clp proteases
YP_002970064.1	COG0038 Chloride channel protein EriC
YP_002970065.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_002970066.1	COG0349 Ribonuclease D
YP_002970067.1	COG1180 Pyruvate-formate lyase-activating enzyme
YP_002970068.1	COG1882 Pyruvate-formate lyase
YP_002970070.1	COG0388 Predicted amidohydrolase
YP_002970071.1	COG1473 Metal-dependentamidase/aminoacylase/carboxypeptidase
YP_002970072.1	COG2011 ABC-type metal ion transport system, permease component
YP_002970073.1	COG1135 ABC-type metal ion transport system, ATPase component
YP_002970074.1	COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen
YP_002970075.1	COG0652 Peptidyl-prolyl cis-trans isomerase (rotamase - cyclophilin family)
YP_002970076.1	COG0317 Guanosine polyphosphatepyrophosphohydrolases/synthetases
YP_002970077.1	COG0756 dUTPase
YP_002970080.1	COG1524 Uncharacterized proteins of the AP superfamily
YP_002970081.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_002970082.1	COG4975 Putative glucose uptake permease
YP_002970083.1	COG1201 Lhr-like helicases
YP_002970085.1	COG0738 Fucose permease
YP_002970086.1	COG0438 Glycosyltransferase
YP_002970087.1	COG0187 Type IIA topoisomerase (DNA gyrase/topo II,topoisomerase IV, B subunit)
YP_002970088.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released
YP_002970090.1	COG0142 Geranylgeranyl pyrophosphate synthase
YP_002970091.1	COG0515 Serine/threonine protein kinase
YP_002970092.1	COG0204 1-acyl-sn-glycerol-3-phosphateacyltransferase
YP_002970094.1	Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_002970095.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_002970096.1	COG1544 Ribosome-associated protein Y (PSrp-1)
YP_002970098.1	COG2137 Uncharacterized protein conserved in bacteria
YP_002970099.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_002970102.1	COG1546 Uncharacterized protein (competence- andmitomycin-induced)
YP_002970103.1	COG0558 Phosphatidylglycerophosphate synthase
YP_002970104.1	COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
YP_002970105.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_002970106.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_002970107.1	COG2357 Uncharacterized protein conserved in bacteria
YP_002970108.1	COG0670 Integral membrane protein, interacts withFtsH
YP_002970109.1	COG3804 Uncharacterized conserved protein related to dihydrodipicolinate reductase
YP_002970111.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002970112.1	COG4585 Signal transduction histidine kinase
YP_002970113.1	COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain
YP_002970115.1	COG3464 Transposase and inactivated derivatives
YP_002970116.1	COG1479 Uncharacterized conserved protein
YP_002970117.1	COG0110 Acetyltransferase (isoleucine patch superfamily)
YP_002970119.1	Catalyzes the conversion of citrate to isocitrate
YP_002970120.1	COG0474 Cation transport ATPase
YP_002970122.1	COG2265 SAM-dependent methyltransferases related to tRNA (uracil-5--methyltransferase)
YP_002970125.1	COG0708 Exonuclease III
YP_002970127.1	COG1123 ATPase components of various ABC-typetransport systems, contain duplicated ATPase
YP_002970128.1	COG1173 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002970129.1	COG0601 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002970130.1	COG0747 ABC-type dipeptide transport system, periplasmic component
YP_002970131.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_002970132.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002970133.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002970135.1	COG0287 Prephenate dehydrogenase
YP_002970136.1	COG0077 Prephenate dehydratase
YP_002970138.1	COG1217 Predicted membrane GTPase involved instress response
YP_002970139.1	COG0477 Permeases of the major facilitator superfamily
YP_002970140.1	COG1051 ADP-ribose pyrophosphatase
YP_002970141.1	COG1192 ATPases involved in chromosome partitioning
YP_002970142.1	COG4974 Site-specific recombinase XerD
YP_002970143.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_002970145.1	COG0290 Translation initiation factor 3 (IF-3)
YP_002970146.1	COG1564 Thiamine pyrophosphokinase
YP_002970147.1	COG0057 Glyceraldehyde-3-phosphatedehydrogenase/erythrose-4- phosphate dehydrogenase
YP_002970148.1	COG2606 Uncharacterized conserved protein
YP_002970149.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_002970150.1	COG2017 Galactose mutarotase and related enzymes
YP_002970152.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_002970153.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_002970154.1	COG2348 Uncharacterized protein involved in methicillin resistance
YP_002970155.1	COG0285 Folylpolyglutamate synthase
YP_002970156.1	COG2197 Response regulator containing a CheY-likereceiver domain and an HTH DNA-binding domain
YP_002970157.1	COG4585 Signal transduction histidine kinase
YP_002970159.1	COG0006 Xaa-Pro aminopeptidase
YP_002970160.1	COG0494 NTP pyrophosphohydrolases including oxidative damage repair enzymes
YP_002970161.1	COG1940 Transcriptional regulator/sugar kinase
YP_002970162.1	COG0524 Sugar kinases, ribokinase family
YP_002970163.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_002970164.1	COG0582 Integrase
YP_002970166.1	COG3311 Predicted transcriptional regulator
YP_002970171.1	COG0305 Replicative DNA helicase
YP_002970176.1	COG3740 Phage head maturation protease
YP_002970178.1	COG1123 ATPase components of various ABC-typetransport systems, contain duplicated ATPase
YP_002970179.1	COG1173 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002970180.1	COG0601 ABC-type dipeptide/oligopeptide/nickeltransport systems, permease components
YP_002970181.1	COG1589 Cell division septal protein
YP_002970182.1	COG0773 UDP-N-acetylmuramate-alanine ligase
YP_002970183.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_002970184.1	COG0772 Bacterial cell division membrane protein
YP_002970185.1	COG0771 UDP-N-acetylmuramoylalanine-D-glutamateligase
YP_002970186.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_002970187.1	COG0770 UDP-N-acetylmuramyl pentapeptide synthase
YP_002970188.1	COG0769 UDP-N-acetylmuramyl tripeptide synthase
YP_002970189.1	COG0768 Cell division proteinFtsI/ penicillin-binding protein 2
YP_002970191.1	COG0275 Predicted S-adenosylmethionine-dependentmethyltransferase involved in cell envelope biogenesis
YP_002970192.1	COG2001 Uncharacterized protein conserved in bacteria
YP_002970193.1	COG3973 Superfamily I DNA and RNA helicases
YP_002970194.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_002970195.1	COG1327 Predicted transcriptional regulator, consists of a Zn-ribbon and ATP-cone domains
YP_002970196.1	COG1388 FOG: LysM repeat
YP_002970197.1	Represses a number of genes involved in the response to DNA damage
YP_002970198.1	COG1230 Co/Zn/Cd efflux system component
YP_002970199.1	COG0039 Malate/lactate dehydrogenases
YP_002970200.1	COG2262 GTPases
YP_002970201.1	COG2813 16S RNA G1207 methylase RsmC
YP_002970202.1	COG1643 HrpA-like helicases
YP_002970203.1	COG0174 Glutamine synthetase
YP_002970204.1	COG4320 Uncharacterized protein conserved in bacteria
YP_002970205.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide and the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)anthranilate; involved in histidine and tryptophan biosynthesis
YP_002970206.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_002970208.1	catalyzes the dehydration of D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate to 3-(imidazol-4-yl)-2-oxopropyl phosphate in histidine biosynthesis
YP_002970209.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_002970210.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_002970211.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_002970213.1	COG0564 Pseudouridylate synthases, 23SRNA-specific
YP_002970214.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_002970215.1	COG3599 Cell division initiation protein
YP_002970216.1	COG0762 Predicted integral membrane protein
YP_002970217.1	COG1799 Uncharacterized protein conserved in bacteria
YP_002970218.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_002970219.1	COG0042 tRNA-dihydrouridine synthase
YP_002970220.1	Catalyzes a two-step reaction, first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_002970221.1	COG2145 Hydroxyethylthiazole kinase, sugar kinase family
YP_002970222.1	COG0352 Thiamine monophosphate synthase
YP_002970223.1	COG0011 Uncharacterized conserved protein
YP_002970224.1	COG1609 Transcriptional regulators
YP_002970225.1	lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments
YP_002970226.1	COG1621 Beta-fructosidases (levanase/invertase)
YP_002970227.1	COG0600 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component
YP_002970228.1	COG0715 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components
YP_002970229.1	COG1957 Inosine-uridine nucleoside N-ribohydrolase
YP_002970231.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_002970232.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_002970233.1	COG1073 Hydrolases of the alpha/beta superfamily
YP_002970234.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_002970235.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_002970237.1	COG1196 Chromosome segregation ATPases
YP_002970238.1	COG2303 Choline dehydrogenase and related flavoproteins
YP_002970239.1	COG3480 Predicted secreted protein containing a PDZ domain
YP_002970240.1	COG5282 Uncharacterized conserved protein
YP_002970241.1	COG0210 Superfamily I DNA and RNA helicases
YP_002970242.1	COG3173 Predicted aminoglycosidephosphotransferase
YP_002970244.1	COG0613 Predicted metal-dependent phosphoesterases (PHP family)
YP_002970245.1	COG4243 Predicted membrane protein
YP_002970246.1	COG0253 Diaminopimelate epimerase
YP_002970247.1	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_002970248.1	COG4667 Predicted esterase of the alpha-betahydrolase superfamily
YP_002970249.1	COG0330 Membrane protease subunits, stomatin/prohibitin homologs
YP_002970250.1	COG0834 ABC-type amino acid transport/signal transduction systems, periplasmic component/domain
YP_002970251.1	COG1126 ABC-type polar amino acid transport system, ATPase component
YP_002970252.1	COG0765 ABC-type amino acid transport system, permease component
YP_002970253.1	COG0765 ABC-type amino acid transport system, permease component
YP_002970254.1	COG0436 Aspartate/tyrosine/aromatic aminotransferase
YP_002970255.1	COG2011 ABC-type metal ion transport system, permease component
YP_002970256.1	COG1135 ABC-type metal ion transport system, ATPase component
YP_002970257.1	COG1464 ABC-type metal ion transport system, periplasmic component/surface antigen
YP_002970258.1	COG1893 Ketopantoate reductase
YP_002970259.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002970260.1	COG2176 DNA polymerase III, alpha subunit (gram-positive type)
YP_002970261.1	COG0480 Translation elongation factors (GTPases)
YP_002970262.1	COG0531 Amino acid transporters
YP_002970265.1	COG4166 ABC-type oligopeptide transport system, periplasmic component
YP_002970266.1	COG0477 Permeases of the major facilitator superfamily
YP_002970267.1	COG1842 Phage shock protein A (IM30, suppresses sigma54-dependent transcription)
YP_002970270.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 2 subfamily; some organisms carry two different copies of this enzyme; in some organisms, the type 2 subfamily is associated with resistance to the antibiotic pseudomonic acid (mupirocin)
YP_002970272.1	COG2365 Protein tyrosine/serine phosphatase
YP_002970275.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002970276.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002970277.1	COG1846 Transcriptional regulators
YP_002970278.1	COG0431 Predicted flavoprotein
YP_002970279.1	COG3727 DNA G:T-mismatch repair endonuclease
YP_002970283.1	COG1196 Chromosome segregation ATPases
YP_002970286.1	COG1343 Uncharacterized protein predicted to beinvolved in DNA repair
YP_002970287.1	COG1518; COG1468 RecB family exonuclease/transl_table
YP_002970288.1	COG3572 Gamma-glutamylcysteine synthetase
YP_002970289.1	COG1924 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain)
YP_002970290.1	COG3548 Predicted integral membrane protein
YP_002970291.1	COG3759 Predicted membrane protein
YP_002970293.1	COG0602 Organic radical activating enzymes
YP_002970294.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_002970295.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_002970296.1	COG1722 Exonuclease VII small subunit
YP_002970297.1	COG3021 Uncharacterized protein conserved in bacteria
YP_002970299.1	COG0436 Aspartate/tyrosine/aromatic aminotransferase
YP_002970300.1	COG3727 DNA G:T-mismatch repair endonuclease
YP_002970302.1	COG0847 DNA polymerase III, epsilon subunit and related 3-5 exonucleases
YP_002970303.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_002970304.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_002970305.1	COG0308 Aminopeptidase N
YP_002970306.1	COG0595 Predicted hydrolase of themetallo-beta-lactamase superfamily
YP_002970307.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_002970308.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_002970309.1	COG0477 Permeases of the major facilitator superfamily
YP_002970310.1	COG0454 Histone acetyltransferase HPA2 and related acetyltransferases
YP_002970311.1	COG0210 Superfamily I DNA and RNA helicases
YP_002970312.1	COG0210 Superfamily I DNA and RNA helicases
YP_002970313.1	COG0515 Serine/threonine protein kinase
YP_002970314.1	COG2931 RTX toxins and related Ca2+-binding proteins
YP_002970315.1	COG0714 MoxR-like ATPases
YP_002970316.1	COG1721 Uncharacterized conserved protein (somemembers contain a von Willebrand factor type A (vWAdomain))
YP_002970317.1	COG1305 Transglutaminase-like enzymes, putative cysteine proteases
YP_002970319.1	COG1716 FOG: FHA domain
YP_002970320.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_002970321.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_002970323.1	COG1194 A/G-specific DNA glycosylase
YP_002970324.1	COG0219 Predicted rRNA methylase (SpoU class))
YP_002970325.1	COG2848 Uncharacterized conserved protein
YP_002970326.1	ACT domain-containing protein
YP_002970327.1	COG3764 Sortase (surface protein transpeptidase)
YP_002970329.1	COG0153 Galactokinase
YP_002970330.1	COG1085 Galactose-1-phosphate uridylyltransferase
YP_002970331.1	COG1349 Transcriptional regulators of sugar metabolism
YP_002970332.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002970333.1	catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_002970334.1	COG1902 NADH:flavin oxidoreductases, Old Yellow Enzyme family
YP_002970335.1	COG0744 Membrane carboxypeptidase (penicillin-binding protein)
YP_002970336.1	COG0664 cAMP-binding proteins - catabolite geneactivator and regulatory subunit of cAMP-dependent protein kinases
YP_002970337.1	COG0095 Lipoate-protein ligase A
YP_002970338.1	COG2314 Predicted membrane protein
YP_002970340.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_002970341.1	COG1770 Protease II
YP_002970342.1	COG4850 Uncharacterized conserved protein
YP_002970343.1	COG0509 Glycine cleavage system H protein (lipoate-binding)
YP_002970344.1	COG2816 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding
YP_002970345.1	COG0596 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily)
YP_002970347.1	COG0526 Thiol-disulfide isomerase and thioredoxins
YP_002970348.1	COG3583 Uncharacterized protein conserved in bacteria
YP_002970349.1	COG2148 Sugar transferases involved inlipopolysaccharide synthesis
YP_002970351.1	COG4713 Predicted membrane protein
YP_002970352.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002970354.1	COG1209 dTDP-glucose pyrophosphorylase
YP_002970355.1	COG1898 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes
YP_002970356.1	COG1088 dTDP-D-glucose 4,6-dehydratase
YP_002970357.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002970358.1	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
YP_002970359.1	COG1216 Predicted glycosyltransferases
YP_002970360.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002970362.1	COG1216 Predicted glycosyltransferases
YP_002970364.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002970366.1	COG1004 Predicted UDP-glucose 6-dehydrogenase
YP_002970367.1	COG2244 Membrane protein involved in the export of O-antigen and teichoic acid
YP_002970369.1	COG1216 Predicted glycosyltransferases
YP_002970370.1	COG2148 Sugar transferases involved inlipopolysaccharide synthesis
YP_002970372.1	COG0477 Permeases of the major facilitator superfamily
YP_002970373.1	COG1914 Mn2+ and Fe2+ transporters of the NRAMP family
YP_002970375.1	with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate
YP_002970376.1	with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate
YP_002970377.1	COG0451 Nucleoside-diphosphate-sugar epimerases
YP_002970378.1	COG0707 UDP-N-acetylglucosamine: LPSN-acetylglucosamine transferase
YP_002970379.1	COG5017 Uncharacterized conserved protein
YP_002970380.1	COG1216 Predicted glycosyltransferases
YP_002970381.1	COG1216 Predicted glycosyltransferases
YP_002970383.1	COG4988 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components
YP_002970384.1	COG1022 Long-chain acyl-CoA synthetases (AMP-forming)
YP_002970385.1	COG0424 Nucleotide-binding protein implicated in inhibition of septum formation
YP_002970386.1	COG0394 Protein-tyrosine-phosphatase
YP_002970388.1	COG3944 Capsular polysaccharide biosynthesis protein
YP_002970391.1	COG3464 Transposase and in activated derivatives
YP_002970392.1	COG0083 Homoserine kinase
YP_002970393.1	catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine
YP_002970394.1	COG0019 Diaminopimelate decarboxylase
YP_002970395.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_002970396.1	COG5520 O-Glycosyl hydrolase
YP_002970397.1	COG0251 Putative translation initiation inhibitor, yjgF family
YP_002970398.1	COG0395 ABC-type sugar transport system, permease component
YP_002970399.1	COG3459 Cellobiose phosphorylase
YP_002970400.1	COG3118 Thioredoxin domain-containing protein
YP_002970403.1	COG0545 FKBP-type peptidyl-prolyl cis-transisomerases 1
YP_002970404.1	COG1637 Predicted nuclease of the RecB family
YP_002970405.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the epsilon subunit is part of the catalytic core of the ATP synthase complex
YP_002970406.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_002970407.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_002970408.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit
YP_002970409.1	produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex
YP_002970410.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.
YP_002970411.1	COG0636 F0F1-type ATP synthase, subunitc/Archaeal/vacuolar-type H+-ATPase, subunit K
YP_002970412.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_002970413.1	catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_002970414.1	COG0477 Permeases of the major facilitator superfamily
YP_002970415.1	COG1957 Inosine-uridine nucleoside N-ribohydrolase
YP_002970419.1	COG1674 DNA segregation ATPase FtsK/SpoIIIE and related proteins
YP_002970420.1	COG1536 Flagellar motor switch protein
YP_002970422.1	COG1479 Uncharacterized conserved protein
YP_002970424.1	COG0582 Integrase
YP_002970425.1	catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA
YP_002970426.1	COG2730 Endoglucanase
YP_002970428.1	COG0679 Predicted permeases
YP_002970429.1	catalyzes the formation of formyl-CoA from oxalyl-CoA
YP_002970430.1	COG0038 Chloride channel protein EriC
YP_002970431.1	COG4932 Predicted outer membrane protein
YP_002970433.1	COG0366 Glycosidases
YP_002970434.1	COG0221 Inorganic pyrophosphatase
YP_002970436.1	COG0745 Response regulators consisting of aCheY-like receiver domain and a winged-helix DNA-binding domain
YP_002970437.1	COG0177 Predicted EndoIII-related endonuclease
YP_002970439.1	COG0747 ABC-type dipeptide transport system, periplasmic component
YP_002970440.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_002970441.1	COG1522 Transcriptional regulators
YP_002970442.1	catalyzes the interconversion of chorismate to prephenate
YP_002970444.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_002970445.1	COG1232 Protoporphyrinogen oxidase
YP_002970447.1	COG1670 Acetyltransferases, including N-acetylasesof ribosomal proteins
YP_002970448.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_002970449.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA
YP_002970450.1	allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain
YP_002970452.1	COG1131 ABC-type multidrug transport system, ATPase component
YP_002970453.1	COG0566 rRNA methylases
YP_002970454.1	COG0461 Orotate phosphoribosyltransferase
YP_002970455.1	COG2217 Cation transport ATPase
YP_002970456.1	COG0542 ATPases with chaperone activity, ATP-binding subunit
YP_002970457.1	COG0179 2-keto-4-pentenoatehydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway)
YP_002970461.1	COG3764 Sortase (surface protein transpeptidase)
YP_002970462.1	COG0325 Predicted enzyme with a TIM-barrel fold
YP_002970463.1	COG0008 Glutamyl- and glutaminyl-tRNA synthetases
YP_002970465.1	COG0580 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)
YP_002970470.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_002970471.1	binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit
YP_002970472.1	binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA
YP_002970473.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_002970474.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_002970475.1	COG0524 Sugar kinases, ribokinase family
YP_002970476.1	COG0477 Permeases of the major facilitator superfamily
YP_002970477.1	COG1957 Inosine-uridine nucleoside N-ribohydrolase
YP_002970478.1	COG1609 Transcriptional regulators
YP_002970479.1	COG0562 UDP-galactopyranose mutase
YP_002970480.1	COG0463 Glycosyltransferases involved in cell wall biogenesis
YP_002970482.1	COG1216 Predicted glycosyltransferases
YP_002970483.1	COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
YP_002970485.1	COG1368 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily
YP_002970486.1	COG1216 Predicted glycosyltransferases
YP_002970487.1	COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase)
YP_002970488.1	COG3757 Lyzozyme M1 (1,4-beta-N-acetylmuramidase)
YP_002970489.1	COG3328 Transposase and inactivated derivatives
YP_002970490.1	COG4886 Leucine-rich repeat (LRR protein)
YP_002970494.1	COG1134 ABC-type polysaccharide/polyol phosphatetransport system, ATPase component
YP_002970495.1	COG1682 ABC-type polysaccharide/polyol phosphateexport systems, permease component
YP_002970496.1	COG1216 Predicted glycosyltransferases
YP_002970501.1	COG0577 ABC-type antimicrobial peptide transport system, permease component
YP_002970502.1	COG1136 ABC-type antimicrobial peptide transport system, ATPase component
YP_002970503.1	COG1418 Predicted HD superfamily hydrolase
YP_002970504.1	COG0121 Predicted glutamine amidotransferase
YP_002970505.1	COG3158 K+ transporter
YP_002970506.1	COG0084 Mg-dependent DNase
YP_002970507.1	COG3345 Alpha-galactosidase
YP_002970509.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002970510.1	COG1132 ABC-type multidrug transport system, ATPase and permease components
YP_002970512.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_002970515.1	COG0313 Predicted methyltransferases
YP_002970516.1	COG1928 Dolichyl-phosphate-mannose--proteinO-mannosyl transferase
YP_002970517.1	COG0657 Esterase/lipase
YP_002970518.1	COG0586 Uncharacterized membrane-associated protein
YP_002970519.1	COG4832 Uncharacterized conserved protein
YP_002970520.1	COG1472 Beta-glucosidase-related glycosidases
YP_002970521.1	COG1309 Transcriptional regulator
YP_002970522.1	COG0637 Predicted phosphatase/phosphohexomutase
YP_002970523.1	COG0789 Predicted transcriptional regulators
YP_002970524.1	COG2214 DnaJ-class molecular chaperone
YP_002970525.1	with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor
YP_002970526.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_002970528.1	COG1609 Transcriptional regulators
YP_002970530.1	COG1011 Predicted hydrolase (HAD superfamily)
YP_002970531.1	COG1523 Type II secretory pathway, pullulanase PulA and related glycosidases
YP_002970532.1	COG0395 ABC-type sugar transport system, permease component
YP_002970533.1	COG1175 ABC-type sugar transport systems, permease components
YP_002970534.1	COG2182 Maltose-binding periplasmic proteins/domains
YP_002970535.1	COG0366 Glycosidases
YP_002970536.1	COG1640 4-alpha-glucanotransferase
YP_002970538.1	COG0395 ABC-type sugar transport system, permease component
YP_002970539.1	COG1175 ABC-type sugar transport systems, permease components
YP_002970540.1	COG1609 Transcriptional regulators
YP_002970541.1	COG1653 ABC-type sugar transport system, periplasmic component
YP_002970542.1	COG0366 Glycosidases
YP_002970543.1	COG0406 Fructose-2,6-bisphosphatase
YP_002970545.1	COG0778 Nitroreductase
YP_002970547.1	COG0477 Permeases of the major facilitator superfamily
YP_002970548.1	COG0388 Predicted amidohydrolase
YP_002970549.1	COG0388 Predicted amidohydrolase
YP_002970550.1	COG3077 DNA-damage-inducible protein J
YP_002970551.1	COG2211 Na+/melibiose symporter and related transporters
YP_002970552.1	COG3533 Uncharacterized protein conserved in bacteria
YP_002970553.1	COG1609 Transcriptional regulators
YP_002970554.1	COG0846 NAD-dependent protein deacetylases, SIR2family
YP_002970555.1	catalyzes the formation of 2-oxobutanoate from L-threonine
YP_002970556.1	COG0366 Glycosidases
YP_002970559.1	COG3345 Alpha-galactosidase
YP_002970560.1	COG0395 ABC-type sugar transport system, permease component
YP_002970561.1	COG1175 ABC-type sugar transport systems, permease components
YP_002970562.1	COG1653 ABC-type sugar transport system, periplasmic component
YP_002970563.1	COG1940 Transcriptional regulator/sugar kinase
YP_002970564.1	COG3345 Alpha-galactosidase
YP_002970565.1	COG0590 Cytosine/adenosine deaminases
YP_002970566.1	COG0025 NhaP-type Na+/H+ and K+/H+ antiporters
YP_002970567.1	COG0400 Predicted esterase
YP_002970569.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_002970570.1	COG0474 Cation transport ATPase
YP_002970571.1	COG0566 rRNA methylases
YP_002970572.1	COG0515 Serine/threonine protein kinase
YP_002970573.1	COG3839 ABC-type sugar transport systems, ATPase components
YP_002970574.1	COG1226 Kef-type K+ transport systems, predictedNAD-binding component
YP_002970575.1	COG0515 Serine/threonine protein kinase
YP_002970576.1	COG1651 Protein-disulfide isomerase
YP_002970577.1	COG3583 Uncharacterized protein conserved in bacteria
YP_002970578.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_002970579.1	COG0030 Dimethyladenosine transferase (rRNAmethylation)
YP_002970581.1	COG0617 tRNA nucleotidyltransferase/poly(Apolymerase)
YP_002970582.1	COG0494 NTP pyrophosphohydrolases includingoxidative damage repair enzymes
YP_002970584.1	COG0728 Uncharacterized membrane protein, putativevirulence factor
YP_002970585.1	COG0492 Thioredoxin reductase
YP_002970586.1	COG1475 Predicted transcriptional regulators
YP_002970587.1	COG1192 ATPases involved in chromosomepartitioning
YP_002970588.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_002970589.1	COG1847 Predicted RNA-binding protein
YP_002970590.1	COG0706 Preprotein translocase subunit YidC
YP_002970591.1	COG0759 Uncharacterized conserved protein
YP_002970592.1	COG0594 RNase P protein component
YP_002970593.1	in Escherichia coli transcription of this gene is enhanced by polyamines