-- dump date 20140619_002140 -- class Genbank::misc_feature -- table misc_feature_note -- id note 555970000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 555970000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970000003 Walker A motif; other site 555970000004 ATP binding site [chemical binding]; other site 555970000005 Walker B motif; other site 555970000006 arginine finger; other site 555970000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 555970000008 DnaA box-binding interface [nucleotide binding]; other site 555970000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 555970000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 555970000011 putative DNA binding surface [nucleotide binding]; other site 555970000012 dimer interface [polypeptide binding]; other site 555970000013 beta-clamp/clamp loader binding surface; other site 555970000014 beta-clamp/translesion DNA polymerase binding surface; other site 555970000015 recombination protein F; Reviewed; Region: recF; PRK00064 555970000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000017 Walker A/P-loop; other site 555970000018 ATP binding site [chemical binding]; other site 555970000019 Q-loop/lid; other site 555970000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000021 ABC transporter signature motif; other site 555970000022 Walker B; other site 555970000023 D-loop; other site 555970000024 H-loop/switch region; other site 555970000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 555970000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 555970000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 555970000028 Mg2+ binding site [ion binding]; other site 555970000029 G-X-G motif; other site 555970000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 555970000031 anchoring element; other site 555970000032 dimer interface [polypeptide binding]; other site 555970000033 ATP binding site [chemical binding]; other site 555970000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 555970000035 active site 555970000036 putative metal-binding site [ion binding]; other site 555970000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 555970000038 DNA gyrase subunit A; Validated; Region: PRK05560 555970000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 555970000040 CAP-like domain; other site 555970000041 active site 555970000042 primary dimer interface [polypeptide binding]; other site 555970000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 555970000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 555970000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 555970000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 555970000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 555970000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 555970000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 555970000050 VanZ like family; Region: VanZ; cl01971 555970000051 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 555970000052 Haemolysin-III related; Region: HlyIII; pfam03006 555970000053 glutamate dehydrogenase; Provisional; Region: PRK09414 555970000054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 555970000055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 555970000056 NAD(P) binding site [chemical binding]; other site 555970000057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970000059 putative substrate translocation pore; other site 555970000060 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 555970000061 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 555970000062 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 555970000063 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 555970000064 Protein of unknown function DUF45; Region: DUF45; pfam01863 555970000065 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 555970000066 MarR family; Region: MarR_2; pfam12802 555970000067 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 555970000068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 555970000069 non-specific DNA interactions [nucleotide binding]; other site 555970000070 DNA binding site [nucleotide binding] 555970000071 sequence specific DNA binding site [nucleotide binding]; other site 555970000072 putative cAMP binding site [chemical binding]; other site 555970000073 6-phosphogluconolactonase; Provisional; Region: PRK11028 555970000074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000075 Walker A/P-loop; other site 555970000076 ATP binding site [chemical binding]; other site 555970000077 Q-loop/lid; other site 555970000078 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 555970000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000080 ABC transporter signature motif; other site 555970000081 Walker B; other site 555970000082 D-loop; other site 555970000083 H-loop/switch region; other site 555970000084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000085 Walker A/P-loop; other site 555970000086 ATP binding site [chemical binding]; other site 555970000087 Q-loop/lid; other site 555970000088 ABC transporter signature motif; other site 555970000089 Walker B; other site 555970000090 D-loop; other site 555970000091 H-loop/switch region; other site 555970000092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 555970000093 S-adenosylmethionine binding site [chemical binding]; other site 555970000094 Predicted flavoprotein [General function prediction only]; Region: COG0431 555970000095 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 555970000096 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 555970000097 homodimer interface [polypeptide binding]; other site 555970000098 chemical substrate binding site [chemical binding]; other site 555970000099 oligomer interface [polypeptide binding]; other site 555970000100 metal binding site [ion binding]; metal-binding site 555970000101 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 555970000102 GIY-YIG motif/motif A; other site 555970000103 active site 555970000104 catalytic site [active] 555970000105 Helix-turn-helix domain; Region: HTH_17; pfam12728 555970000106 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 555970000107 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 555970000108 cofactor binding site; other site 555970000109 DNA binding site [nucleotide binding] 555970000110 substrate interaction site [chemical binding]; other site 555970000111 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 555970000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 555970000113 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 555970000114 PemK-like protein; Region: PemK; pfam02452 555970000115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 555970000116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 555970000117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 555970000118 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 555970000119 catalytic tetrad [active] 555970000120 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 555970000121 active site 555970000122 catalytic tetrad [active] 555970000123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 555970000124 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 555970000125 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 555970000126 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 555970000127 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 555970000128 potential frameshift: common BLAST hit:gi|116630082|ref|YP_815254.1| aminoglycosidephosphotransferase 555970000129 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 555970000130 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 555970000131 Transposase; Region: DDE_Tnp_ISL3; pfam01610 555970000132 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 555970000133 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 555970000134 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 555970000135 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 555970000136 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 555970000137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970000138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970000139 putative substrate translocation pore; other site 555970000140 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 555970000141 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 555970000142 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 555970000143 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 555970000144 dimerization interface [polypeptide binding]; other site 555970000145 DPS ferroxidase diiron center [ion binding]; other site 555970000146 ion pore; other site 555970000147 Domain of unknown function DUF21; Region: DUF21; pfam01595 555970000148 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 555970000149 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 555970000150 Transporter associated domain; Region: CorC_HlyC; smart01091 555970000151 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 555970000152 active site clefts [active] 555970000153 zinc binding site [ion binding]; other site 555970000154 dimer interface [polypeptide binding]; other site 555970000155 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970000156 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970000157 DNA binding site [nucleotide binding] 555970000158 domain linker motif; other site 555970000159 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 555970000160 ligand binding site [chemical binding]; other site 555970000161 dimerization interface (open form) [polypeptide binding]; other site 555970000162 dimerization interface (closed form) [polypeptide binding]; other site 555970000163 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 555970000164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000165 ABC transporter; Region: ABC_tran; pfam00005 555970000166 Q-loop/lid; other site 555970000167 ABC transporter signature motif; other site 555970000168 Walker B; other site 555970000169 D-loop; other site 555970000170 H-loop/switch region; other site 555970000171 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970000172 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970000173 DNA binding site [nucleotide binding] 555970000174 domain linker motif; other site 555970000175 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 555970000176 ligand binding site [chemical binding]; other site 555970000177 dimerization interface [polypeptide binding]; other site 555970000178 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 555970000179 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 555970000180 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 555970000181 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 555970000182 putative N- and C-terminal domain interface [polypeptide binding]; other site 555970000183 putative active site [active] 555970000184 MgATP binding site [chemical binding]; other site 555970000185 catalytic site [active] 555970000186 metal binding site [ion binding]; metal-binding site 555970000187 putative carbohydrate binding site [chemical binding]; other site 555970000188 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 555970000189 intersubunit interface [polypeptide binding]; other site 555970000190 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 555970000191 active site 555970000192 Zn2+ binding site [ion binding]; other site 555970000193 L-arabinose isomerase; Provisional; Region: PRK02929 555970000194 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 555970000195 hexamer (dimer of trimers) interface [polypeptide binding]; other site 555970000196 trimer interface [polypeptide binding]; other site 555970000197 substrate binding site [chemical binding]; other site 555970000198 Mn binding site [ion binding]; other site 555970000199 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 555970000200 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 555970000201 active site 555970000202 catalytic tetrad [active] 555970000203 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 555970000204 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 555970000205 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 555970000206 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 555970000207 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 555970000208 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 555970000209 Transposase; Region: DDE_Tnp_ISL3; pfam01610 555970000210 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 555970000211 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 555970000212 active site 555970000213 HIGH motif; other site 555970000214 dimer interface [polypeptide binding]; other site 555970000215 KMSKS motif; other site 555970000216 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 555970000217 homodimer interface [polypeptide binding]; other site 555970000218 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 555970000219 active site pocket [active] 555970000220 Rhomboid family; Region: Rhomboid; pfam01694 555970000221 Methyltransferase domain; Region: Methyltransf_26; pfam13659 555970000222 putative septation inhibitor protein; Reviewed; Region: PRK02251 555970000223 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 555970000224 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 555970000225 active site 555970000226 catalytic site [active] 555970000227 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 555970000228 Glutamine amidotransferase class-I; Region: GATase; pfam00117 555970000229 glutamine binding [chemical binding]; other site 555970000230 catalytic triad [active] 555970000231 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 555970000232 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 555970000233 active site 555970000234 ATP binding site [chemical binding]; other site 555970000235 substrate binding site [chemical binding]; other site 555970000236 activation loop (A-loop); other site 555970000237 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 555970000238 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 555970000239 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 555970000240 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 555970000241 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 555970000242 Catalytic domain of Protein Kinases; Region: PKc; cd00180 555970000243 active site 555970000244 ATP binding site [chemical binding]; other site 555970000245 substrate binding site [chemical binding]; other site 555970000246 activation loop (A-loop); other site 555970000247 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 555970000248 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 555970000249 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 555970000250 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 555970000251 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 555970000252 active site 555970000253 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 555970000254 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 555970000255 phosphopeptide binding site; other site 555970000256 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 555970000257 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 555970000258 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 555970000259 phosphopeptide binding site; other site 555970000260 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 555970000261 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 555970000262 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 555970000263 EamA-like transporter family; Region: EamA; pfam00892 555970000264 EamA-like transporter family; Region: EamA; pfam00892 555970000265 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 555970000266 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 555970000267 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 555970000268 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 555970000269 S-adenosylmethionine binding site [chemical binding]; other site 555970000270 Predicted membrane protein [Function unknown]; Region: COG2261 555970000271 ferredoxin-NADP+ reductase; Region: PLN02852 555970000272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 555970000273 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 555970000274 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 555970000275 Soluble P-type ATPase [General function prediction only]; Region: COG4087 555970000276 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 555970000277 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 555970000278 protein binding site [polypeptide binding]; other site 555970000279 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 555970000280 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 555970000281 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 555970000282 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 555970000283 heat shock protein HtpX; Provisional; Region: PRK03072 555970000284 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 555970000285 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 555970000286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970000287 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970000288 putative substrate translocation pore; other site 555970000289 RelB antitoxin; Region: RelB; cl01171 555970000290 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 555970000291 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 555970000292 DNA binding site [nucleotide binding] 555970000293 active site 555970000294 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 555970000295 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 555970000296 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 555970000297 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 555970000298 Transcriptional regulator [Transcription]; Region: LysR; COG0583 555970000299 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 555970000300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 555970000301 dimerization interface [polypeptide binding]; other site 555970000302 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 555970000303 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 555970000304 active site 555970000305 catalytic tetrad [active] 555970000306 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 555970000307 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 555970000308 FAD binding pocket [chemical binding]; other site 555970000309 conserved FAD binding motif [chemical binding]; other site 555970000310 phosphate binding motif [ion binding]; other site 555970000311 beta-alpha-beta structure motif; other site 555970000312 NAD binding pocket [chemical binding]; other site 555970000313 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 555970000314 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 555970000315 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 555970000316 DNA binding residues [nucleotide binding] 555970000317 putative dimer interface [polypeptide binding]; other site 555970000318 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 555970000319 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 555970000320 NADH(P)-binding; Region: NAD_binding_10; pfam13460 555970000321 NAD(P) binding site [chemical binding]; other site 555970000322 putative active site [active] 555970000323 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 555970000324 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 555970000325 catalytic Zn binding site [ion binding]; other site 555970000326 NAD(P) binding site [chemical binding]; other site 555970000327 structural Zn binding site [ion binding]; other site 555970000328 Transcriptional regulator [Transcription]; Region: LysR; COG0583 555970000329 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 555970000330 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 555970000331 dimerization interface [polypeptide binding]; other site 555970000332 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 555970000333 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 555970000334 NodB motif; other site 555970000335 active site 555970000336 catalytic site [active] 555970000337 metal binding site [ion binding]; metal-binding site 555970000338 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 555970000339 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 555970000340 active site 555970000341 intersubunit interface [polypeptide binding]; other site 555970000342 zinc binding site [ion binding]; other site 555970000343 Na+ binding site [ion binding]; other site 555970000344 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 555970000345 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 555970000346 GDP-binding site [chemical binding]; other site 555970000347 ACT binding site; other site 555970000348 IMP binding site; other site 555970000349 CrcB-like protein; Region: CRCB; pfam02537 555970000350 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 555970000351 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 555970000352 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 555970000353 TM-ABC transporter signature motif; other site 555970000354 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 555970000355 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 555970000356 TM-ABC transporter signature motif; other site 555970000357 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 555970000358 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 555970000359 Walker A/P-loop; other site 555970000360 ATP binding site [chemical binding]; other site 555970000361 Q-loop/lid; other site 555970000362 ABC transporter signature motif; other site 555970000363 Walker B; other site 555970000364 D-loop; other site 555970000365 H-loop/switch region; other site 555970000366 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 555970000367 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 555970000368 Walker A/P-loop; other site 555970000369 ATP binding site [chemical binding]; other site 555970000370 Q-loop/lid; other site 555970000371 ABC transporter signature motif; other site 555970000372 Walker B; other site 555970000373 D-loop; other site 555970000374 H-loop/switch region; other site 555970000375 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 555970000376 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 555970000377 ligand binding site [chemical binding]; other site 555970000378 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970000379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970000380 DNA binding site [nucleotide binding] 555970000381 domain linker motif; other site 555970000382 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 555970000383 sucrose phosphorylase; Provisional; Region: PRK13840 555970000384 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 555970000385 active site 555970000386 homodimer interface [polypeptide binding]; other site 555970000387 catalytic site [active] 555970000388 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 555970000389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970000390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970000391 putative substrate translocation pore; other site 555970000392 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 555970000393 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 555970000394 ligand binding site [chemical binding]; other site 555970000395 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 555970000396 ATP-grasp domain; Region: ATP-grasp_4; cl17255 555970000397 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 555970000398 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 555970000399 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 555970000400 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 555970000401 metabolite-proton symporter; Region: 2A0106; TIGR00883 555970000402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970000403 putative substrate translocation pore; other site 555970000404 ketol-acid reductoisomerase; Provisional; Region: PRK05479 555970000405 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 555970000406 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 555970000407 Domain of unknown function (DUF303); Region: DUF303; pfam03629 555970000408 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 555970000409 active site 555970000410 catalytic triad [active] 555970000411 oxyanion hole [active] 555970000412 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 555970000413 beta-galactosidase; Region: BGL; TIGR03356 555970000414 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970000415 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970000416 DNA binding site [nucleotide binding] 555970000417 domain linker motif; other site 555970000418 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 555970000419 ligand binding site [chemical binding]; other site 555970000420 dimerization interface [polypeptide binding]; other site 555970000421 Protein of unknown function, DUF624; Region: DUF624; pfam04854 555970000422 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 555970000423 putative active cleft [active] 555970000424 dimerization interface [polypeptide binding]; other site 555970000425 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 555970000426 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000427 Walker A/P-loop; other site 555970000428 ATP binding site [chemical binding]; other site 555970000429 Q-loop/lid; other site 555970000430 ABC transporter signature motif; other site 555970000431 Walker B; other site 555970000432 D-loop; other site 555970000433 H-loop/switch region; other site 555970000434 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 555970000435 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 555970000436 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 555970000437 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 555970000438 Walker A/P-loop; other site 555970000439 ATP binding site [chemical binding]; other site 555970000440 Q-loop/lid; other site 555970000441 ABC transporter signature motif; other site 555970000442 Walker B; other site 555970000443 D-loop; other site 555970000444 H-loop/switch region; other site 555970000445 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 555970000446 FtsX-like permease family; Region: FtsX; pfam02687 555970000447 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 555970000448 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 555970000449 potential frameshift: common BLAST hit: gi|219683212|ref|YP_002469595.1| putative ABC transport system integral membrane protein 555970000450 potential frameshift: common BLAST hit: gi|219683212|ref|YP_002469595.1| putative ABC transport system integral membrane protein 555970000451 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 555970000452 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 555970000453 FtsX-like permease family; Region: FtsX; pfam02687 555970000454 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000455 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 555970000456 ABC transporter signature motif; other site 555970000457 Walker B; other site 555970000458 D-loop; other site 555970000459 H-loop/switch region; other site 555970000460 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 555970000461 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 555970000462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 555970000463 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000464 Walker A/P-loop; other site 555970000465 ATP binding site [chemical binding]; other site 555970000466 Q-loop/lid; other site 555970000467 ABC transporter signature motif; other site 555970000468 Walker B; other site 555970000469 D-loop; other site 555970000470 H-loop/switch region; other site 555970000471 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 555970000472 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 555970000473 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 555970000474 Walker A/P-loop; other site 555970000475 ATP binding site [chemical binding]; other site 555970000476 Q-loop/lid; other site 555970000477 ABC transporter signature motif; other site 555970000478 Walker B; other site 555970000479 D-loop; other site 555970000480 H-loop/switch region; other site 555970000481 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 555970000482 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 555970000483 NodB motif; other site 555970000484 active site 555970000485 catalytic site [active] 555970000486 metal binding site [ion binding]; metal-binding site 555970000487 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 555970000488 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 555970000489 active site 555970000490 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 555970000491 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 555970000492 active site 555970000493 substrate binding site [chemical binding]; other site 555970000494 trimer interface [polypeptide binding]; other site 555970000495 CoA binding site [chemical binding]; other site 555970000496 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 555970000497 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 555970000498 ligand binding site [chemical binding]; other site 555970000499 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 555970000500 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 555970000501 Predicted membrane protein [Function unknown]; Region: COG1511 555970000502 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 555970000503 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 555970000504 Predicted membrane protein [Function unknown]; Region: COG1511 555970000505 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 555970000506 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 555970000507 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 555970000508 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 555970000509 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 555970000510 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 555970000511 Walker A/P-loop; other site 555970000512 ATP binding site [chemical binding]; other site 555970000513 Q-loop/lid; other site 555970000514 ABC transporter signature motif; other site 555970000515 Walker B; other site 555970000516 D-loop; other site 555970000517 H-loop/switch region; other site 555970000518 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970000519 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 555970000520 Walker A/P-loop; other site 555970000521 ATP binding site [chemical binding]; other site 555970000522 Q-loop/lid; other site 555970000523 ABC transporter signature motif; other site 555970000524 Walker B; other site 555970000525 D-loop; other site 555970000526 H-loop/switch region; other site 555970000527 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 555970000528 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 555970000529 intersubunit interface [polypeptide binding]; other site 555970000530 YodA lipocalin-like domain; Region: YodA; cl01365 555970000531 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 555970000532 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 555970000533 active site 555970000534 nucleophile elbow; other site 555970000535 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 555970000536 Peptidase family C69; Region: Peptidase_C69; pfam03577 555970000537 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 555970000538 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 555970000539 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 555970000540 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 555970000541 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 555970000542 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 555970000543 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 555970000544 Nitrogen regulatory protein P-II; Region: P-II; smart00938 555970000545 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 555970000546 metal binding triad; other site 555970000547 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 555970000548 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 555970000549 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 555970000550 sequence-specific DNA binding site [nucleotide binding]; other site 555970000551 salt bridge; other site 555970000552 replicative DNA helicase; Region: DnaB; TIGR00665 555970000553 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 555970000554 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 555970000555 Walker A motif; other site 555970000556 ATP binding site [chemical binding]; other site 555970000557 Walker B motif; other site 555970000558 DNA binding loops [nucleotide binding] 555970000559 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 555970000560 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 555970000561 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 555970000562 catalytic triad [active] 555970000563 Uncharacterized conserved protein [Function unknown]; Region: COG3937 555970000564 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 555970000565 ABC1 family; Region: ABC1; cl17513 555970000566 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 555970000567 active site 555970000568 catalytic site [active] 555970000569 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 555970000570 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 555970000571 active site 555970000572 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 555970000573 active site 555970000574 Ap6A binding site [chemical binding]; other site 555970000575 nudix motif; other site 555970000576 metal binding site [ion binding]; metal-binding site 555970000577 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970000578 catalytic core [active] 555970000579 polyphosphate kinase; Provisional; Region: PRK05443 555970000580 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 555970000581 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 555970000582 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 555970000583 putative domain interface [polypeptide binding]; other site 555970000584 putative active site [active] 555970000585 catalytic site [active] 555970000586 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 555970000587 putative domain interface [polypeptide binding]; other site 555970000588 putative active site [active] 555970000589 catalytic site [active] 555970000590 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 555970000591 Type II/IV secretion system protein; Region: T2SE; pfam00437 555970000592 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 555970000593 Walker B motif; other site 555970000594 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 555970000595 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 555970000596 TadE-like protein; Region: TadE; pfam07811 555970000597 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 555970000598 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970000599 Walker A motif; other site 555970000600 ATP binding site [chemical binding]; other site 555970000601 Walker B motif; other site 555970000602 arginine finger; other site 555970000603 recombination protein RecR; Reviewed; Region: recR; PRK00076 555970000604 RecR protein; Region: RecR; pfam02132 555970000605 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 555970000606 putative active site [active] 555970000607 putative metal-binding site [ion binding]; other site 555970000608 tetramer interface [polypeptide binding]; other site 555970000609 aspartate kinase; Reviewed; Region: PRK06635 555970000610 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 555970000611 putative nucleotide binding site [chemical binding]; other site 555970000612 putative catalytic residues [active] 555970000613 putative Mg ion binding site [ion binding]; other site 555970000614 putative aspartate binding site [chemical binding]; other site 555970000615 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 555970000616 putative allosteric regulatory site; other site 555970000617 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 555970000618 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 555970000619 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 555970000620 2-isopropylmalate synthase; Validated; Region: PRK03739 555970000621 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 555970000622 active site 555970000623 catalytic residues [active] 555970000624 metal binding site [ion binding]; metal-binding site 555970000625 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 555970000626 Transglycosylase; Region: Transgly; pfam00912 555970000627 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 555970000628 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 555970000629 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 555970000630 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 555970000631 PAP2 superfamily; Region: PAP2; pfam01569 555970000632 active site 555970000633 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 555970000634 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 555970000635 active site 555970000636 interdomain interaction site; other site 555970000637 putative metal-binding site [ion binding]; other site 555970000638 nucleotide binding site [chemical binding]; other site 555970000639 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 555970000640 domain I; other site 555970000641 phosphate binding site [ion binding]; other site 555970000642 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 555970000643 domain II; other site 555970000644 domain III; other site 555970000645 nucleotide binding site [chemical binding]; other site 555970000646 DNA binding groove [nucleotide binding] 555970000647 catalytic site [active] 555970000648 domain IV; other site 555970000649 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 555970000650 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 555970000651 thymidylate kinase; Validated; Region: tmk; PRK00698 555970000652 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 555970000653 TMP-binding site; other site 555970000654 ATP-binding site [chemical binding]; other site 555970000655 DNA polymerase III subunit delta'; Validated; Region: PRK07940 555970000656 DNA polymerase III subunit delta'; Validated; Region: PRK08485 555970000657 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 555970000658 substrate binding site [chemical binding]; other site 555970000659 Peptidase family C69; Region: Peptidase_C69; pfam03577 555970000660 Peptidase family C69; Region: Peptidase_C69; pfam03577 555970000661 AAA domain; Region: AAA_14; pfam13173 555970000662 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 555970000663 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 555970000664 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 555970000665 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 555970000666 putative active site [active] 555970000667 Predicted membrane protein [Function unknown]; Region: COG2246 555970000668 GtrA-like protein; Region: GtrA; pfam04138 555970000669 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970000670 catalytic core [active] 555970000671 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970000672 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970000673 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 555970000674 Transposase; Region: DDE_Tnp_ISL3; pfam01610 555970000675 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 555970000676 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 555970000677 active site 555970000678 HIGH motif; other site 555970000679 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 555970000680 active site 555970000681 KMSKS motif; other site 555970000682 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 555970000683 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 555970000684 putative active site [active] 555970000685 putative metal binding site [ion binding]; other site 555970000686 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 555970000687 Transcriptional regulator [Transcription]; Region: IclR; COG1414 555970000688 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 555970000689 Bacterial transcriptional regulator; Region: IclR; pfam01614 555970000690 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 555970000691 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 555970000692 substrate binding site [chemical binding]; other site 555970000693 ligand binding site [chemical binding]; other site 555970000694 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 555970000695 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 555970000696 substrate binding site [chemical binding]; other site 555970000697 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 555970000698 AsnC family; Region: AsnC_trans_reg; pfam01037 555970000699 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 555970000700 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 555970000701 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 555970000702 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 555970000703 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 555970000704 hinge; other site 555970000705 active site 555970000706 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 555970000707 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 555970000708 putative acyl-acceptor binding pocket; other site 555970000709 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 555970000710 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 555970000711 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 555970000712 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 555970000713 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 555970000714 ATP-grasp domain; Region: ATP-grasp_4; cl17255 555970000715 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 555970000716 CAAX protease self-immunity; Region: Abi; pfam02517 555970000717 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 555970000718 Mechanosensitive ion channel; Region: MS_channel; pfam00924 555970000719 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 555970000720 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 555970000721 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 555970000722 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 555970000723 nucleophilic elbow; other site 555970000724 catalytic triad; other site 555970000725 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 555970000726 Predicted membrane protein [Function unknown]; Region: COG4905 555970000727 aspartate aminotransferase; Provisional; Region: PRK06836 555970000728 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970000729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970000730 homodimer interface [polypeptide binding]; other site 555970000731 catalytic residue [active] 555970000732 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 555970000733 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 555970000734 binding surface 555970000735 TPR motif; other site 555970000736 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 555970000737 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 555970000738 substrate binding site [chemical binding]; other site 555970000739 ATP binding site [chemical binding]; other site 555970000740 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 555970000741 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 555970000742 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 555970000743 ssDNA binding site; other site 555970000744 generic binding surface II; other site 555970000745 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 555970000746 ATP binding site [chemical binding]; other site 555970000747 putative Mg++ binding site [ion binding]; other site 555970000748 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970000749 nucleotide binding region [chemical binding]; other site 555970000750 ATP-binding site [chemical binding]; other site 555970000751 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 555970000752 metal ion-dependent adhesion site (MIDAS); other site 555970000753 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 555970000754 T surface-antigen of pili; Region: FctA; pfam12892 555970000755 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 555970000756 T surface-antigen of pili; Region: FctA; pfam12892 555970000757 T surface-antigen of pili; Region: FctA; pfam12892 555970000758 T surface-antigen of pili; Region: FctA; pfam12892 555970000759 T surface-antigen of pili; Region: FctA; pfam12892 555970000760 T surface-antigen of pili; Region: FctA; pfam12892 555970000761 T surface-antigen of pili; Region: FctA; pfam12892 555970000762 T surface-antigen of pili; Region: FctA; pfam12892 555970000763 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 555970000764 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 555970000765 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 555970000766 S-adenosylmethionine binding site [chemical binding]; other site 555970000767 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 555970000768 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 555970000769 RimM N-terminal domain; Region: RimM; pfam01782 555970000770 PRC-barrel domain; Region: PRC; pfam05239 555970000771 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 555970000772 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 555970000773 G-X-X-G motif; other site 555970000774 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 555970000775 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 555970000776 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 555970000777 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 555970000778 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 555970000779 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 555970000780 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 555970000781 putative catalytic site [active] 555970000782 putative metal binding site [ion binding]; other site 555970000783 putative phosphate binding site [ion binding]; other site 555970000784 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 555970000785 putative catalytic site [active] 555970000786 putative phosphate binding site [ion binding]; other site 555970000787 putative metal binding site [ion binding]; other site 555970000788 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 555970000789 Cation efflux family; Region: Cation_efflux; pfam01545 555970000790 signal recognition particle protein; Provisional; Region: PRK10867 555970000791 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 555970000792 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 555970000793 P loop; other site 555970000794 GTP binding site [chemical binding]; other site 555970000795 Signal peptide binding domain; Region: SRP_SPB; pfam02978 555970000796 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 555970000797 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 555970000798 active site 555970000799 HIGH motif; other site 555970000800 nucleotide binding site [chemical binding]; other site 555970000801 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 555970000802 KMSKS motif; other site 555970000803 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 555970000804 tRNA binding surface [nucleotide binding]; other site 555970000805 anticodon binding site; other site 555970000806 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 555970000807 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 555970000808 ABC transporter; Region: ABC_tran_2; pfam12848 555970000809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 555970000810 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 555970000811 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 555970000812 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 555970000813 catalytic triad [active] 555970000814 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 555970000815 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 555970000816 putative valine binding site [chemical binding]; other site 555970000817 dimer interface [polypeptide binding]; other site 555970000818 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 555970000819 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 555970000820 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 555970000821 PYR/PP interface [polypeptide binding]; other site 555970000822 dimer interface [polypeptide binding]; other site 555970000823 TPP binding site [chemical binding]; other site 555970000824 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 555970000825 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 555970000826 TPP-binding site [chemical binding]; other site 555970000827 dimer interface [polypeptide binding]; other site 555970000828 ribonuclease III; Reviewed; Region: rnc; PRK00102 555970000829 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 555970000830 dimerization interface [polypeptide binding]; other site 555970000831 active site 555970000832 metal binding site [ion binding]; metal-binding site 555970000833 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 555970000834 dsRNA binding site [nucleotide binding]; other site 555970000835 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 555970000836 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 555970000837 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 555970000838 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 555970000839 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 555970000840 active site 555970000841 (T/H)XGH motif; other site 555970000842 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 555970000843 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 555970000844 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 555970000845 active site 555970000846 catalytic tetrad [active] 555970000847 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 555970000848 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 555970000849 active site 555970000850 Ribonuclease PH; Region: RNase_PH_bact; cd11362 555970000851 ribonuclease PH; Reviewed; Region: rph; PRK00173 555970000852 hexamer interface [polypeptide binding]; other site 555970000853 active site 555970000854 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 555970000855 active site 555970000856 dimerization interface [polypeptide binding]; other site 555970000857 FemAB family; Region: FemAB; pfam02388 555970000858 Membrane transport protein; Region: Mem_trans; cl09117 555970000859 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 555970000860 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 555970000861 Substrate binding site; other site 555970000862 Cupin domain; Region: Cupin_2; cl17218 555970000863 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 555970000864 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 555970000865 active site 555970000866 dimer interface [polypeptide binding]; other site 555970000867 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 555970000868 dimer interface [polypeptide binding]; other site 555970000869 active site 555970000870 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 555970000871 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 555970000872 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 555970000873 Catalytic site [active] 555970000874 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 555970000875 RNA/DNA hybrid binding site [nucleotide binding]; other site 555970000876 active site 555970000877 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 555970000878 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 555970000879 Walker A/P-loop; other site 555970000880 ATP binding site [chemical binding]; other site 555970000881 Q-loop/lid; other site 555970000882 ABC transporter signature motif; other site 555970000883 Walker B; other site 555970000884 D-loop; other site 555970000885 H-loop/switch region; other site 555970000886 FtsX-like permease family; Region: FtsX; pfam02687 555970000887 Predicted permeases [General function prediction only]; Region: COG0679 555970000888 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 555970000889 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 555970000890 metal binding site [ion binding]; metal-binding site 555970000891 putative dimer interface [polypeptide binding]; other site 555970000892 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 555970000893 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 555970000894 homodimer interface [polypeptide binding]; other site 555970000895 oligonucleotide binding site [chemical binding]; other site 555970000896 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 555970000897 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 555970000898 GTPase CgtA; Reviewed; Region: obgE; PRK12296 555970000899 GTP1/OBG; Region: GTP1_OBG; pfam01018 555970000900 Obg GTPase; Region: Obg; cd01898 555970000901 G1 box; other site 555970000902 GTP/Mg2+ binding site [chemical binding]; other site 555970000903 Switch I region; other site 555970000904 G2 box; other site 555970000905 G3 box; other site 555970000906 Switch II region; other site 555970000907 G4 box; other site 555970000908 G5 box; other site 555970000909 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 555970000910 gamma-glutamyl kinase; Provisional; Region: PRK05429 555970000911 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 555970000912 nucleotide binding site [chemical binding]; other site 555970000913 homotetrameric interface [polypeptide binding]; other site 555970000914 putative phosphate binding site [ion binding]; other site 555970000915 putative allosteric binding site; other site 555970000916 PUA domain; Region: PUA; pfam01472 555970000917 aspartate aminotransferase; Provisional; Region: PRK05764 555970000918 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970000919 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970000920 homodimer interface [polypeptide binding]; other site 555970000921 catalytic residue [active] 555970000922 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 555970000923 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 555970000924 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 555970000925 putative homodimer interface [polypeptide binding]; other site 555970000926 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 555970000927 heterodimer interface [polypeptide binding]; other site 555970000928 homodimer interface [polypeptide binding]; other site 555970000929 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 555970000930 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 555970000931 23S rRNA interface [nucleotide binding]; other site 555970000932 L7/L12 interface [polypeptide binding]; other site 555970000933 putative thiostrepton binding site; other site 555970000934 L25 interface [polypeptide binding]; other site 555970000935 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 555970000936 mRNA/rRNA interface [nucleotide binding]; other site 555970000937 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 555970000938 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 555970000939 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 555970000940 BioY family; Region: BioY; pfam02632 555970000941 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 555970000942 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 555970000943 ATP-grasp domain; Region: ATP-grasp_4; cl17255 555970000944 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 555970000945 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 555970000946 carboxyltransferase (CT) interaction site; other site 555970000947 biotinylation site [posttranslational modification]; other site 555970000948 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 555970000949 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 555970000950 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 555970000951 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 555970000952 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 555970000953 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 555970000954 FMN binding site [chemical binding]; other site 555970000955 substrate binding site [chemical binding]; other site 555970000956 putative catalytic residue [active] 555970000957 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 555970000958 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 555970000959 active site 2 [active] 555970000960 active site 1 [active] 555970000961 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 555970000962 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 555970000963 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 555970000964 putative NAD(P) binding site [chemical binding]; other site 555970000965 active site 555970000966 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 555970000967 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 555970000968 active site 555970000969 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 555970000970 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 555970000971 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 555970000972 NAD binding site [chemical binding]; other site 555970000973 dimer interface [polypeptide binding]; other site 555970000974 tetramer (dimer of dimers) interface [polypeptide binding]; other site 555970000975 substrate binding site [chemical binding]; other site 555970000976 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 555970000977 16S/18S rRNA binding site [nucleotide binding]; other site 555970000978 S13e-L30e interaction site [polypeptide binding]; other site 555970000979 25S rRNA binding site [nucleotide binding]; other site 555970000980 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 555970000981 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 555970000982 oligomer interface [polypeptide binding]; other site 555970000983 RNA binding site [nucleotide binding]; other site 555970000984 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 555970000985 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 555970000986 RNase E interface [polypeptide binding]; other site 555970000987 trimer interface [polypeptide binding]; other site 555970000988 active site 555970000989 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 555970000990 putative nucleic acid binding region [nucleotide binding]; other site 555970000991 G-X-X-G motif; other site 555970000992 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 555970000993 RNA binding site [nucleotide binding]; other site 555970000994 domain interface; other site 555970000995 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 555970000996 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 555970000997 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 555970000998 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 555970000999 dimer interface [polypeptide binding]; other site 555970001000 putative radical transfer pathway; other site 555970001001 diiron center [ion binding]; other site 555970001002 tyrosyl radical; other site 555970001003 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 555970001004 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 555970001005 Class I ribonucleotide reductase; Region: RNR_I; cd01679 555970001006 active site 555970001007 dimer interface [polypeptide binding]; other site 555970001008 catalytic residues [active] 555970001009 effector binding site; other site 555970001010 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 555970001011 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 555970001012 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 555970001013 catalytic residues [active] 555970001014 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 555970001015 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 555970001016 active site 555970001017 catalytic tetrad [active] 555970001018 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 555970001019 Peptidase family U32; Region: Peptidase_U32; pfam01136 555970001020 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 555970001021 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 555970001022 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 555970001023 substrate binding site; other site 555970001024 dimer interface; other site 555970001025 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 555970001026 putative substrate binding pocket [chemical binding]; other site 555970001027 AC domain interface; other site 555970001028 catalytic triad [active] 555970001029 AB domain interface; other site 555970001030 interchain disulfide; other site 555970001031 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 555970001032 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 555970001033 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 555970001034 trimer interface [polypeptide binding]; other site 555970001035 active site 555970001036 G bulge; other site 555970001037 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 555970001038 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 555970001039 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 555970001040 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 555970001041 catalytic triad [active] 555970001042 catalytic triad [active] 555970001043 oxyanion hole [active] 555970001044 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 555970001045 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 555970001046 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 555970001047 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 555970001048 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 555970001049 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 555970001050 dimer interface [polypeptide binding]; other site 555970001051 phosphorylation site [posttranslational modification] 555970001052 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 555970001053 ATP binding site [chemical binding]; other site 555970001054 Mg2+ binding site [ion binding]; other site 555970001055 G-X-G motif; other site 555970001056 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 555970001057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 555970001058 active site 555970001059 phosphorylation site [posttranslational modification] 555970001060 intermolecular recognition site; other site 555970001061 dimerization interface [polypeptide binding]; other site 555970001062 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 555970001063 DNA binding site [nucleotide binding] 555970001064 PBP superfamily domain; Region: PBP_like_2; cl17296 555970001065 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 555970001066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970001067 dimer interface [polypeptide binding]; other site 555970001068 conserved gate region; other site 555970001069 putative PBP binding loops; other site 555970001070 ABC-ATPase subunit interface; other site 555970001071 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 555970001072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970001073 dimer interface [polypeptide binding]; other site 555970001074 conserved gate region; other site 555970001075 putative PBP binding loops; other site 555970001076 ABC-ATPase subunit interface; other site 555970001077 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 555970001078 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 555970001079 Walker A/P-loop; other site 555970001080 ATP binding site [chemical binding]; other site 555970001081 Q-loop/lid; other site 555970001082 ABC transporter signature motif; other site 555970001083 Walker B; other site 555970001084 D-loop; other site 555970001085 H-loop/switch region; other site 555970001086 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 555970001087 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 555970001088 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 555970001089 intersubunit interface [polypeptide binding]; other site 555970001090 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 555970001091 23S rRNA interface [nucleotide binding]; other site 555970001092 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 555970001093 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 555970001094 peripheral dimer interface [polypeptide binding]; other site 555970001095 core dimer interface [polypeptide binding]; other site 555970001096 L10 interface [polypeptide binding]; other site 555970001097 L11 interface [polypeptide binding]; other site 555970001098 putative EF-Tu interaction site [polypeptide binding]; other site 555970001099 putative EF-G interaction site [polypeptide binding]; other site 555970001100 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 555970001101 phosphopeptide binding site; other site 555970001102 Part of AAA domain; Region: AAA_19; pfam13245 555970001103 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 555970001104 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 555970001105 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 555970001106 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 555970001107 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 555970001108 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 555970001109 Coenzyme A binding pocket [chemical binding]; other site 555970001110 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 555970001111 oligomerisation interface [polypeptide binding]; other site 555970001112 mobile loop; other site 555970001113 roof hairpin; other site 555970001114 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 555970001115 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 555970001116 FAD binding domain; Region: FAD_binding_4; pfam01565 555970001117 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 555970001118 amino acid transporter; Region: 2A0306; TIGR00909 555970001119 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 555970001120 Ferredoxin [Energy production and conversion]; Region: COG1146 555970001121 4Fe-4S binding domain; Region: Fer4; pfam00037 555970001122 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 555970001123 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970001124 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970001125 homodimer interface [polypeptide binding]; other site 555970001126 catalytic residue [active] 555970001127 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 555970001128 active site 555970001129 DNA polymerase IV; Validated; Region: PRK02406 555970001130 DNA binding site [nucleotide binding] 555970001131 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 555970001132 dimerization interface [polypeptide binding]; other site 555970001133 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 555970001134 NAD binding site [chemical binding]; other site 555970001135 ligand binding site [chemical binding]; other site 555970001136 catalytic site [active] 555970001137 Uncharacterized conserved protein [Function unknown]; Region: COG1739 555970001138 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 555970001139 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 555970001140 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 555970001141 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 555970001142 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 555970001143 23S rRNA interface [nucleotide binding]; other site 555970001144 L3 interface [polypeptide binding]; other site 555970001145 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 555970001146 pullulanase, type I; Region: pulA_typeI; TIGR02104 555970001147 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 555970001148 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 555970001149 active site 555970001150 catalytic site [active] 555970001151 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 555970001152 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 555970001153 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 555970001154 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 555970001155 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 555970001156 putative catalytic cysteine [active] 555970001157 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 555970001158 putative active site [active] 555970001159 metal binding site [ion binding]; metal-binding site 555970001160 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 555970001161 YwiC-like protein; Region: YwiC; pfam14256 555970001162 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 555970001163 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 555970001164 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 555970001165 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 555970001166 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 555970001167 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 555970001168 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 555970001169 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 555970001170 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 555970001171 putative translocon binding site; other site 555970001172 protein-rRNA interface [nucleotide binding]; other site 555970001173 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 555970001174 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 555970001175 G-X-X-G motif; other site 555970001176 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 555970001177 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 555970001178 23S rRNA interface [nucleotide binding]; other site 555970001179 5S rRNA interface [nucleotide binding]; other site 555970001180 putative antibiotic binding site [chemical binding]; other site 555970001181 L25 interface [polypeptide binding]; other site 555970001182 L27 interface [polypeptide binding]; other site 555970001183 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 555970001184 23S rRNA interface [nucleotide binding]; other site 555970001185 putative translocon interaction site; other site 555970001186 signal recognition particle (SRP54) interaction site; other site 555970001187 L23 interface [polypeptide binding]; other site 555970001188 trigger factor interaction site; other site 555970001189 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 555970001190 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 555970001191 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 555970001192 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 555970001193 RNA binding site [nucleotide binding]; other site 555970001194 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 555970001195 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 555970001196 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 555970001197 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 555970001198 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 555970001199 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 555970001200 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 555970001201 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 555970001202 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 555970001203 23S rRNA interface [nucleotide binding]; other site 555970001204 L21e interface [polypeptide binding]; other site 555970001205 5S rRNA interface [nucleotide binding]; other site 555970001206 L27 interface [polypeptide binding]; other site 555970001207 L5 interface [polypeptide binding]; other site 555970001208 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 555970001209 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 555970001210 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 555970001211 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 555970001212 23S rRNA binding site [nucleotide binding]; other site 555970001213 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 555970001214 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 555970001215 SecY translocase; Region: SecY; pfam00344 555970001216 adenylate kinase; Reviewed; Region: adk; PRK00279 555970001217 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 555970001218 AMP-binding site [chemical binding]; other site 555970001219 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 555970001220 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 555970001221 rRNA binding site [nucleotide binding]; other site 555970001222 predicted 30S ribosome binding site; other site 555970001223 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 555970001224 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 555970001225 30S ribosomal protein S13; Region: bact_S13; TIGR03631 555970001226 30S ribosomal protein S11; Validated; Region: PRK05309 555970001227 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 555970001228 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 555970001229 alphaNTD homodimer interface [polypeptide binding]; other site 555970001230 alphaNTD - beta interaction site [polypeptide binding]; other site 555970001231 alphaNTD - beta' interaction site [polypeptide binding]; other site 555970001232 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 555970001233 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 555970001234 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 555970001235 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 555970001236 active site 555970001237 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 555970001238 NusA N-terminal domain; Region: NusA_N; pfam08529 555970001239 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 555970001240 RNA binding site [nucleotide binding]; other site 555970001241 homodimer interface [polypeptide binding]; other site 555970001242 NusA-like KH domain; Region: KH_5; pfam13184 555970001243 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 555970001244 G-X-X-G motif; other site 555970001245 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 555970001246 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 555970001247 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 555970001248 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 555970001249 G1 box; other site 555970001250 putative GEF interaction site [polypeptide binding]; other site 555970001251 GTP/Mg2+ binding site [chemical binding]; other site 555970001252 Switch I region; other site 555970001253 G2 box; other site 555970001254 G3 box; other site 555970001255 Switch II region; other site 555970001256 G4 box; other site 555970001257 G5 box; other site 555970001258 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 555970001259 Translation-initiation factor 2; Region: IF-2; pfam11987 555970001260 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 555970001261 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 555970001262 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 555970001263 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 555970001264 RNA binding site [nucleotide binding]; other site 555970001265 active site 555970001266 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 555970001267 FAD synthetase; Region: FAD_syn; pfam06574 555970001268 active site 555970001269 nucleotide binding site [chemical binding]; other site 555970001270 HIGH motif; other site 555970001271 KMSKS motif; other site 555970001272 Riboflavin kinase; Region: Flavokinase; smart00904 555970001273 DNA repair protein RadA; Provisional; Region: PRK11823 555970001274 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 555970001275 Walker A motif; other site 555970001276 ATP binding site [chemical binding]; other site 555970001277 Walker B motif; other site 555970001278 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 555970001279 ADP-ribosylation factor GTPase-activating protein AGD10; Provisional; Region: PLN03114 555970001280 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 555970001281 tetramer (dimer of dimers) interface [polypeptide binding]; other site 555970001282 active site 555970001283 dimer interface [polypeptide binding]; other site 555970001284 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 555970001285 RNA/DNA hybrid binding site [nucleotide binding]; other site 555970001286 active site 555970001287 potential RNA location 498892 ...498979 (tRNA-S and potential protein location 498852....499043 overlap by 88 bp) 555970001288 seryl-tRNA synthetase; Provisional; Region: PRK05431 555970001289 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 555970001290 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 555970001291 dimer interface [polypeptide binding]; other site 555970001292 active site 555970001293 motif 1; other site 555970001294 motif 2; other site 555970001295 motif 3; other site 555970001296 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 555970001297 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 555970001298 phosphoglucomutase; Validated; Region: PRK07564 555970001299 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 555970001300 active site 555970001301 substrate binding site [chemical binding]; other site 555970001302 metal binding site [ion binding]; metal-binding site 555970001303 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 555970001304 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 555970001305 Tetratricopeptide repeat; Region: TPR_12; pfam13424 555970001306 Tetratricopeptide repeat; Region: TPR_12; pfam13424 555970001307 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 555970001308 binding surface 555970001309 TPR motif; other site 555970001310 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 555970001311 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 555970001312 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 555970001313 active site 555970001314 phosphorylation site [posttranslational modification] 555970001315 intermolecular recognition site; other site 555970001316 dimerization interface [polypeptide binding]; other site 555970001317 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 555970001318 DNA binding residues [nucleotide binding] 555970001319 dimerization interface [polypeptide binding]; other site 555970001320 PspC domain; Region: PspC; pfam04024 555970001321 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 555970001322 PspC domain; Region: PspC; pfam04024 555970001323 IncA protein; Region: IncA; pfam04156 555970001324 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 555970001325 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 555970001326 homodimer interface [polypeptide binding]; other site 555970001327 substrate-cofactor binding pocket; other site 555970001328 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970001329 catalytic residue [active] 555970001330 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 555970001331 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 555970001332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 555970001333 catalytic residue [active] 555970001334 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 555970001335 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 555970001336 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 555970001337 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 555970001338 dimer interface [polypeptide binding]; other site 555970001339 putative anticodon binding site; other site 555970001340 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 555970001341 motif 1; other site 555970001342 dimer interface [polypeptide binding]; other site 555970001343 active site 555970001344 motif 2; other site 555970001345 motif 3; other site 555970001346 Phospholipase B; Region: Phospholip_B; pfam04916 555970001347 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 555970001348 trimer interface [polypeptide binding]; other site 555970001349 active site 555970001350 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 555970001351 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 555970001352 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 555970001353 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 555970001354 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 555970001355 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 555970001356 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 555970001357 UbiA prenyltransferase family; Region: UbiA; pfam01040 555970001358 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970001359 catalytic core [active] 555970001360 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970001361 myosin-cross-reactive antigen; Provisional; Region: PRK13977 555970001362 potential frameshift: common BLAST hit:gi|184154213|ref|YP_001842554.1| oxidoreductase 555970001363 mannose-6-phosphate isomerase; Region: PLN02288 555970001364 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 555970001365 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 555970001366 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 555970001367 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 555970001368 ATP binding site [chemical binding]; other site 555970001369 Mg2+ binding site [ion binding]; other site 555970001370 G-X-G motif; other site 555970001371 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 555970001372 PhoU domain; Region: PhoU; pfam01895 555970001373 PhoU domain; Region: PhoU; pfam01895 555970001374 phosphoserine aminotransferase; Provisional; Region: PRK03080 555970001375 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 555970001376 catalytic residue [active] 555970001377 CHAP domain; Region: CHAP; pfam05257 555970001378 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 555970001379 NlpC/P60 family; Region: NLPC_P60; cl17555 555970001380 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 555970001381 Ligand Binding Site [chemical binding]; other site 555970001382 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 555970001383 Ligand Binding Site [chemical binding]; other site 555970001384 OsmC-like protein; Region: OsmC; cl00767 555970001385 thymidylate synthase; Reviewed; Region: thyA; PRK01827 555970001386 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 555970001387 dimerization interface [polypeptide binding]; other site 555970001388 active site 555970001389 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 555970001390 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 555970001391 folate binding site [chemical binding]; other site 555970001392 NADP+ binding site [chemical binding]; other site 555970001393 Low molecular weight phosphatase family; Region: LMWPc; cd00115 555970001394 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 555970001395 active site 555970001396 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 555970001397 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 555970001398 NAD(P) binding site [chemical binding]; other site 555970001399 active site 555970001400 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 555970001401 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 555970001402 putative active site [active] 555970001403 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 555970001404 serine/threonine protein kinase; Provisional; Region: PRK14879 555970001405 AAA domain; Region: AAA_21; pfam13304 555970001406 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 555970001407 putative active site [active] 555970001408 putative metal-binding site [ion binding]; other site 555970001409 Cutinase; Region: Cutinase; pfam01083 555970001410 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 555970001411 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 555970001412 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 555970001413 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 555970001414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 555970001415 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 555970001416 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 555970001417 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 555970001418 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 555970001419 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 555970001420 Uncharacterized conserved protein [Function unknown]; Region: COG3189 555970001421 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 555970001422 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 555970001423 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 555970001424 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 555970001425 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 555970001426 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 555970001427 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 555970001428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970001429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970001430 DNA binding site [nucleotide binding] 555970001431 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 555970001432 putative dimerization interface [polypeptide binding]; other site 555970001433 putative ligand binding site [chemical binding]; other site 555970001434 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 555970001435 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970001436 motif II; other site 555970001437 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 555970001438 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 555970001439 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 555970001440 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 555970001441 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 555970001442 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 555970001443 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 555970001444 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 555970001445 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 555970001446 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970001447 dimer interface [polypeptide binding]; other site 555970001448 conserved gate region; other site 555970001449 putative PBP binding loops; other site 555970001450 ABC-ATPase subunit interface; other site 555970001451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970001452 dimer interface [polypeptide binding]; other site 555970001453 conserved gate region; other site 555970001454 putative PBP binding loops; other site 555970001455 ABC-ATPase subunit interface; other site 555970001456 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970001457 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970001458 DNA binding site [nucleotide binding] 555970001459 domain linker motif; other site 555970001460 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 555970001461 ligand binding site [chemical binding]; other site 555970001462 dimerization interface (open form) [polypeptide binding]; other site 555970001463 dimerization interface (closed form) [polypeptide binding]; other site 555970001464 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 555970001465 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 555970001466 active site 555970001467 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 555970001468 Domain of unknown function DUF20; Region: UPF0118; pfam01594 555970001469 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 555970001470 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 555970001471 DXD motif; other site 555970001472 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 555970001473 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 555970001474 Walker A/P-loop; other site 555970001475 ATP binding site [chemical binding]; other site 555970001476 Q-loop/lid; other site 555970001477 ABC transporter signature motif; other site 555970001478 Walker B; other site 555970001479 D-loop; other site 555970001480 H-loop/switch region; other site 555970001481 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 555970001482 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 555970001483 Ligand Binding Site [chemical binding]; other site 555970001484 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 555970001485 active site 555970001486 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 555970001487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970001488 Walker A motif; other site 555970001489 ATP binding site [chemical binding]; other site 555970001490 Walker B motif; other site 555970001491 arginine finger; other site 555970001492 Peptidase family M41; Region: Peptidase_M41; pfam01434 555970001493 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 555970001494 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 555970001495 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 555970001496 active site 555970001497 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 555970001498 catalytic triad [active] 555970001499 dimer interface [polypeptide binding]; other site 555970001500 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 555970001501 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 555970001502 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 555970001503 ABC transporter; Region: ABC_tran_2; pfam12848 555970001504 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 555970001505 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 555970001506 active site 555970001507 catalytic residues [active] 555970001508 metal binding site [ion binding]; metal-binding site 555970001509 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 555970001510 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 555970001511 homodimer interface [polypeptide binding]; other site 555970001512 substrate-cofactor binding pocket; other site 555970001513 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970001514 catalytic residue [active] 555970001515 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 555970001516 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 555970001517 xylose isomerase; Provisional; Region: PRK05474 555970001518 xylose isomerase; Region: xylose_isom_A; TIGR02630 555970001519 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 555970001520 active site 555970001521 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970001522 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970001523 DNA binding site [nucleotide binding] 555970001524 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 555970001525 putative ligand binding site [chemical binding]; other site 555970001526 putative dimerization interface [polypeptide binding]; other site 555970001527 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 555970001528 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 555970001529 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 555970001530 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970001531 dimer interface [polypeptide binding]; other site 555970001532 conserved gate region; other site 555970001533 putative PBP binding loops; other site 555970001534 ABC-ATPase subunit interface; other site 555970001535 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 555970001536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970001537 dimer interface [polypeptide binding]; other site 555970001538 conserved gate region; other site 555970001539 putative PBP binding loops; other site 555970001540 ABC-ATPase subunit interface; other site 555970001541 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 555970001542 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 555970001543 inhibitor binding site; inhibition site 555970001544 active site 555970001545 Domain of unknown function (DUF303); Region: DUF303; pfam03629 555970001546 Domain of unknown function (DUF303); Region: DUF303; pfam03629 555970001547 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 555970001548 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 555970001549 substrate binding pocket [chemical binding]; other site 555970001550 catalytic triad [active] 555970001551 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 555970001552 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 555970001553 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 555970001554 active site 555970001555 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 555970001556 D-xylulose kinase; Region: XylB; TIGR01312 555970001557 nucleotide binding site [chemical binding]; other site 555970001558 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 555970001559 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 555970001560 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 555970001561 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 555970001562 peptide chain release factor 1; Validated; Region: prfA; PRK00591 555970001563 PCRF domain; Region: PCRF; pfam03462 555970001564 RF-1 domain; Region: RF-1; pfam00472 555970001565 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 555970001566 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 555970001567 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 555970001568 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 555970001569 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 555970001570 Mg++ binding site [ion binding]; other site 555970001571 putative catalytic motif [active] 555970001572 substrate binding site [chemical binding]; other site 555970001573 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 555970001574 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 555970001575 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 555970001576 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 555970001577 active site 555970001578 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 555970001579 catalytic site [active] 555970001580 putative active site [active] 555970001581 putative substrate binding site [chemical binding]; other site 555970001582 dimer interface [polypeptide binding]; other site 555970001583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970001584 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 555970001585 active site 555970001586 motif I; other site 555970001587 motif II; other site 555970001588 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 555970001589 AAA domain; Region: AAA_30; pfam13604 555970001590 PIF1-like helicase; Region: PIF1; pfam05970 555970001591 Protein of unknown function (DUF805); Region: DUF805; cl01224 555970001592 prolyl-tRNA synthetase; Provisional; Region: PRK09194 555970001593 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 555970001594 dimer interface [polypeptide binding]; other site 555970001595 motif 1; other site 555970001596 active site 555970001597 motif 2; other site 555970001598 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 555970001599 putative deacylase active site [active] 555970001600 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 555970001601 active site 555970001602 motif 3; other site 555970001603 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 555970001604 anticodon binding site; other site 555970001605 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 555970001606 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 555970001607 dimer interface [polypeptide binding]; other site 555970001608 ssDNA binding site [nucleotide binding]; other site 555970001609 tetramer (dimer of dimers) interface [polypeptide binding]; other site 555970001610 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 555970001611 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 555970001612 active site 555970001613 Zn binding site [ion binding]; other site 555970001614 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 555970001615 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 555970001616 active site 555970001617 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 555970001618 Citrate synthase; Region: Citrate_synt; pfam00285 555970001619 oxalacetate binding site [chemical binding]; other site 555970001620 citrylCoA binding site [chemical binding]; other site 555970001621 coenzyme A binding site [chemical binding]; other site 555970001622 catalytic triad [active] 555970001623 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 555970001624 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 555970001625 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 555970001626 putative trimer interface [polypeptide binding]; other site 555970001627 putative CoA binding site [chemical binding]; other site 555970001628 peptide chain release factor 2; Validated; Region: prfB; PRK00578 555970001629 This domain is found in peptide chain release factors; Region: PCRF; smart00937 555970001630 RF-1 domain; Region: RF-1; pfam00472 555970001631 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 555970001632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970001633 Walker A/P-loop; other site 555970001634 ATP binding site [chemical binding]; other site 555970001635 Q-loop/lid; other site 555970001636 ABC transporter signature motif; other site 555970001637 Walker B; other site 555970001638 D-loop; other site 555970001639 H-loop/switch region; other site 555970001640 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 555970001641 FtsX-like permease family; Region: FtsX; pfam02687 555970001642 Surface antigen [General function prediction only]; Region: COG3942 555970001643 CHAP domain; Region: CHAP; pfam05257 555970001644 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 555970001645 SmpB-tmRNA interface; other site 555970001646 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 555970001647 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 555970001648 substrate binding pocket [chemical binding]; other site 555970001649 membrane-bound complex binding site; other site 555970001650 hinge residues; other site 555970001651 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 555970001652 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 555970001653 substrate binding pocket [chemical binding]; other site 555970001654 membrane-bound complex binding site; other site 555970001655 hinge residues; other site 555970001656 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 555970001657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970001658 dimer interface [polypeptide binding]; other site 555970001659 conserved gate region; other site 555970001660 putative PBP binding loops; other site 555970001661 ABC-ATPase subunit interface; other site 555970001662 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 555970001663 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 555970001664 Walker A/P-loop; other site 555970001665 ATP binding site [chemical binding]; other site 555970001666 Q-loop/lid; other site 555970001667 ABC transporter signature motif; other site 555970001668 Walker B; other site 555970001669 D-loop; other site 555970001670 H-loop/switch region; other site 555970001671 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 555970001672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 555970001673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 555970001674 active site 555970001675 phosphorylation site [posttranslational modification] 555970001676 intermolecular recognition site; other site 555970001677 dimerization interface [polypeptide binding]; other site 555970001678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 555970001679 DNA binding residues [nucleotide binding] 555970001680 dimerization interface [polypeptide binding]; other site 555970001681 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 555970001682 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 555970001683 glutaminase active site [active] 555970001684 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 555970001685 dimer interface [polypeptide binding]; other site 555970001686 active site 555970001687 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 555970001688 dimer interface [polypeptide binding]; other site 555970001689 active site 555970001690 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 555970001691 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 555970001692 active site 555970001693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster...; Region: Radical_SAM; cl14056 555970001694 pantothenate kinase; Reviewed; Region: PRK13318 555970001695 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 555970001696 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 555970001697 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 555970001698 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970001699 dimer interface [polypeptide binding]; other site 555970001700 conserved gate region; other site 555970001701 putative PBP binding loops; other site 555970001702 ABC-ATPase subunit interface; other site 555970001703 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 555970001704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970001705 dimer interface [polypeptide binding]; other site 555970001706 conserved gate region; other site 555970001707 putative PBP binding loops; other site 555970001708 ABC-ATPase subunit interface; other site 555970001709 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 555970001710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 555970001711 Walker A/P-loop; other site 555970001712 ATP binding site [chemical binding]; other site 555970001713 Q-loop/lid; other site 555970001714 ABC transporter signature motif; other site 555970001715 Walker B; other site 555970001716 D-loop; other site 555970001717 H-loop/switch region; other site 555970001718 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 555970001719 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 555970001720 Walker A/P-loop; other site 555970001721 ATP binding site [chemical binding]; other site 555970001722 Q-loop/lid; other site 555970001723 ABC transporter signature motif; other site 555970001724 Walker B; other site 555970001725 D-loop; other site 555970001726 H-loop/switch region; other site 555970001727 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 555970001728 cystathionine gamma-synthase; Provisional; Region: PRK07811 555970001729 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 555970001730 homodimer interface [polypeptide binding]; other site 555970001731 substrate-cofactor binding pocket; other site 555970001732 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970001733 catalytic residue [active] 555970001734 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 555970001735 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 555970001736 dimer interface [polypeptide binding]; other site 555970001737 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970001738 catalytic residue [active] 555970001739 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 555970001740 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 555970001741 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 555970001742 ATP binding site [chemical binding]; other site 555970001743 ATP binding site [chemical binding]; other site 555970001744 putative Mg++ binding site [ion binding]; other site 555970001745 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970001746 nucleotide binding region [chemical binding]; other site 555970001747 ATP-binding site [chemical binding]; other site 555970001748 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 555970001749 HRDC domain; Region: HRDC; pfam00570 555970001750 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 555970001751 putative active site [active] 555970001752 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 555970001753 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 555970001754 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 555970001755 active site 555970001756 8-oxo-dGMP binding site [chemical binding]; other site 555970001757 nudix motif; other site 555970001758 metal binding site [ion binding]; metal-binding site 555970001759 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 555970001760 PLD-like domain; Region: PLDc_2; pfam13091 555970001761 putative homodimer interface [polypeptide binding]; other site 555970001762 putative active site [active] 555970001763 catalytic site [active] 555970001764 DEAD-like helicases superfamily; Region: DEXDc; smart00487 555970001765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 555970001766 ATP binding site [chemical binding]; other site 555970001767 putative Mg++ binding site [ion binding]; other site 555970001768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970001769 nucleotide binding region [chemical binding]; other site 555970001770 ATP-binding site [chemical binding]; other site 555970001771 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 555970001772 Fic family protein [Function unknown]; Region: COG3177 555970001773 Protein of unknown function DUF262; Region: DUF262; pfam03235 555970001774 Uncharacterized conserved protein [Function unknown]; Region: COG1479 555970001775 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 555970001776 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 555970001777 Fic/DOC family; Region: Fic; cl00960 555970001778 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 555970001779 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 555970001780 Coenzyme A binding pocket [chemical binding]; other site 555970001781 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 555970001782 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 555970001783 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 555970001784 putative active site [active] 555970001785 metal binding site [ion binding]; metal-binding site 555970001786 S-ribosylhomocysteinase; Provisional; Region: PRK02260 555970001787 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 555970001788 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 555970001789 alanine racemase; Reviewed; Region: alr; PRK00053 555970001790 active site 555970001791 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 555970001792 dimer interface [polypeptide binding]; other site 555970001793 substrate binding site [chemical binding]; other site 555970001794 catalytic residues [active] 555970001795 DNA primase; Validated; Region: dnaG; PRK05667 555970001796 CHC2 zinc finger; Region: zf-CHC2; pfam01807 555970001797 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 555970001798 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 555970001799 active site 555970001800 metal binding site [ion binding]; metal-binding site 555970001801 interdomain interaction site; other site 555970001802 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 555970001803 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 555970001804 transmembrane helices; other site 555970001805 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 555970001806 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 555970001807 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 555970001808 TPP-binding site; other site 555970001809 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 555970001810 PYR/PP interface [polypeptide binding]; other site 555970001811 dimer interface [polypeptide binding]; other site 555970001812 TPP binding site [chemical binding]; other site 555970001813 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 555970001814 AIR carboxylase; Region: AIRC; pfam00731 555970001815 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 555970001816 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 555970001817 NAD binding site [chemical binding]; other site 555970001818 ATP-grasp domain; Region: ATP-grasp; pfam02222 555970001819 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 555970001820 metal binding site 2 [ion binding]; metal-binding site 555970001821 putative DNA binding helix; other site 555970001822 metal binding site 1 [ion binding]; metal-binding site 555970001823 dimer interface [polypeptide binding]; other site 555970001824 structural Zn2+ binding site [ion binding]; other site 555970001825 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 555970001826 Putative esterase; Region: Esterase; pfam00756 555970001827 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 555970001828 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 555970001829 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 555970001830 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 555970001831 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 555970001832 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 555970001833 dimerization interface [polypeptide binding]; other site 555970001834 putative ATP binding site [chemical binding]; other site 555970001835 amidophosphoribosyltransferase; Provisional; Region: PRK07272 555970001836 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 555970001837 active site 555970001838 tetramer interface [polypeptide binding]; other site 555970001839 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 555970001840 active site 555970001841 Y-family of DNA polymerases; Region: PolY; cl12025 555970001842 DNA polymerase IV; Reviewed; Region: PRK03103 555970001843 active site 555970001844 DNA binding site [nucleotide binding] 555970001845 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 555970001846 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 555970001847 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665 555970001848 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 555970001849 Short C-terminal domain; Region: SHOCT; pfam09851 555970001850 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 555970001851 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 555970001852 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 555970001853 dimerization interface [polypeptide binding]; other site 555970001854 ATP binding site [chemical binding]; other site 555970001855 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 555970001856 dimerization interface [polypeptide binding]; other site 555970001857 ATP binding site [chemical binding]; other site 555970001858 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 555970001859 conserved cys residue [active] 555970001860 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 555970001861 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 555970001862 ATP binding site [chemical binding]; other site 555970001863 active site 555970001864 substrate binding site [chemical binding]; other site 555970001865 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 555970001866 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 555970001867 ATP-grasp domain; Region: ATP-grasp; pfam02222 555970001868 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 555970001869 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 555970001870 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 555970001871 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 555970001872 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 555970001873 catalytic residue [active] 555970001874 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 555970001875 S17 interaction site [polypeptide binding]; other site 555970001876 S8 interaction site; other site 555970001877 16S rRNA interaction site [nucleotide binding]; other site 555970001878 streptomycin interaction site [chemical binding]; other site 555970001879 23S rRNA interaction site [nucleotide binding]; other site 555970001880 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 555970001881 30S ribosomal protein S7; Validated; Region: PRK05302 555970001882 elongation factor G; Reviewed; Region: PRK00007 555970001883 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 555970001884 G1 box; other site 555970001885 putative GEF interaction site [polypeptide binding]; other site 555970001886 GTP/Mg2+ binding site [chemical binding]; other site 555970001887 Switch I region; other site 555970001888 G2 box; other site 555970001889 G3 box; other site 555970001890 Switch II region; other site 555970001891 G4 box; other site 555970001892 G5 box; other site 555970001893 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 555970001894 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 555970001895 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 555970001896 elongation factor Tu; Reviewed; Region: PRK00049 555970001897 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 555970001898 G1 box; other site 555970001899 GEF interaction site [polypeptide binding]; other site 555970001900 GTP/Mg2+ binding site [chemical binding]; other site 555970001901 Switch I region; other site 555970001902 G2 box; other site 555970001903 G3 box; other site 555970001904 Switch II region; other site 555970001905 G4 box; other site 555970001906 G5 box; other site 555970001907 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 555970001908 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 555970001909 Antibiotic Binding Site [chemical binding]; other site 555970001910 Plant phosphoribosyltransferase C-terminal; Region: PRT_C; pfam08372 555970001911 elongation factor P; Validated; Region: PRK00529 555970001912 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 555970001913 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 555970001914 RNA binding site [nucleotide binding]; other site 555970001915 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 555970001916 RNA binding site [nucleotide binding]; other site 555970001917 transcription antitermination factor NusB; Region: nusB; TIGR01951 555970001918 putative RNA binding site [nucleotide binding]; other site 555970001919 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 555970001920 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 555970001921 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 555970001922 catalytic site [active] 555970001923 subunit interface [polypeptide binding]; other site 555970001924 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 555970001925 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 555970001926 ATP-grasp domain; Region: ATP-grasp_4; cl17255 555970001927 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 555970001928 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 555970001929 ATP-grasp domain; Region: ATP-grasp_4; cl17255 555970001930 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 555970001931 IMP binding site; other site 555970001932 dimer interface [polypeptide binding]; other site 555970001933 interdomain contacts; other site 555970001934 partial ornithine binding site; other site 555970001935 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 555970001936 active site 555970001937 dimer interface [polypeptide binding]; other site 555970001938 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 555970001939 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 555970001940 catalytic site [active] 555970001941 G-X2-G-X-G-K; other site 555970001942 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 555970001943 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 555970001944 S-adenosylmethionine synthetase; Validated; Region: PRK05250 555970001945 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 555970001946 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 555970001947 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 555970001948 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 555970001949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 555970001950 S-adenosylmethionine binding site [chemical binding]; other site 555970001951 primosome assembly protein PriA; Provisional; Region: PRK14873 555970001952 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 555970001953 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 555970001954 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 555970001955 substrate binding site [chemical binding]; other site 555970001956 putative active site [active] 555970001957 putative cosubstrate binding site; other site 555970001958 catalytic site [active] 555970001959 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 555970001960 substrate binding site [chemical binding]; other site 555970001961 phosphoserine phosphatase SerB; Region: serB; TIGR00338 555970001962 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970001963 motif II; other site 555970001964 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 555970001965 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 555970001966 proteasome ATPase; Region: pup_AAA; TIGR03689 555970001967 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970001968 Walker A motif; other site 555970001969 ATP binding site [chemical binding]; other site 555970001970 Walker B motif; other site 555970001971 arginine finger; other site 555970001972 Pup-ligase protein; Region: Pup_ligase; cl15463 555970001973 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 555970001974 active site 555970001975 Pup-like protein; Region: Pup; cl05289 555970001976 Pup-ligase protein; Region: Pup_ligase; cl15463 555970001977 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 555970001978 IHF dimer interface [polypeptide binding]; other site 555970001979 IHF - DNA interface [nucleotide binding]; other site 555970001980 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 555970001981 adenylosuccinate lyase; Provisional; Region: PRK09285 555970001982 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 555970001983 tetramer interface [polypeptide binding]; other site 555970001984 active site 555970001985 Secretory lipase; Region: LIP; pfam03583 555970001986 von Willebrand factor type A domain; Region: VWA_2; pfam13519 555970001987 metal ion-dependent adhesion site (MIDAS); other site 555970001988 von Willebrand factor type A domain; Region: VWA_2; pfam13519 555970001989 metal ion-dependent adhesion site (MIDAS); other site 555970001990 Protein of unknown function DUF58; Region: DUF58; pfam01882 555970001991 MoxR-like ATPases [General function prediction only]; Region: COG0714 555970001992 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 555970001993 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 555970001994 ligand binding site [chemical binding]; other site 555970001995 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 555970001996 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 555970001997 DNA-binding site [nucleotide binding]; DNA binding site 555970001998 RNA-binding motif; other site 555970001999 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 555970002000 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 555970002001 ring oligomerisation interface [polypeptide binding]; other site 555970002002 ATP/Mg binding site [chemical binding]; other site 555970002003 stacking interactions; other site 555970002004 hinge regions; other site 555970002005 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 555970002006 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 555970002007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 555970002008 active site 555970002009 phosphorylation site [posttranslational modification] 555970002010 intermolecular recognition site; other site 555970002011 dimerization interface [polypeptide binding]; other site 555970002012 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 555970002013 DNA binding site [nucleotide binding] 555970002014 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 555970002015 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 555970002016 dimerization interface [polypeptide binding]; other site 555970002017 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 555970002018 dimer interface [polypeptide binding]; other site 555970002019 phosphorylation site [posttranslational modification] 555970002020 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 555970002021 ATP binding site [chemical binding]; other site 555970002022 Mg2+ binding site [ion binding]; other site 555970002023 G-X-G motif; other site 555970002024 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 555970002025 DNA-binding site [nucleotide binding]; DNA binding site 555970002026 RNA-binding motif; other site 555970002027 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 555970002028 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 555970002029 Ligand Binding Site [chemical binding]; other site 555970002030 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 555970002031 Ligand Binding Site [chemical binding]; other site 555970002032 Clp protease ATP binding subunit; Region: clpC; CHL00095 555970002033 Clp amino terminal domain; Region: Clp_N; pfam02861 555970002034 Clp amino terminal domain; Region: Clp_N; pfam02861 555970002035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970002036 Walker A motif; other site 555970002037 ATP binding site [chemical binding]; other site 555970002038 Walker B motif; other site 555970002039 arginine finger; other site 555970002040 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970002041 Walker A motif; other site 555970002042 ATP binding site [chemical binding]; other site 555970002043 Walker B motif; other site 555970002044 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 555970002045 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 555970002046 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 555970002047 dimer interface [polypeptide binding]; other site 555970002048 anticodon binding site; other site 555970002049 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 555970002050 motif 1; other site 555970002051 dimer interface [polypeptide binding]; other site 555970002052 active site 555970002053 motif 2; other site 555970002054 GAD domain; Region: GAD; pfam02938 555970002055 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 555970002056 active site 555970002057 motif 3; other site 555970002058 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 555970002059 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 555970002060 dimer interface [polypeptide binding]; other site 555970002061 motif 1; other site 555970002062 active site 555970002063 motif 2; other site 555970002064 motif 3; other site 555970002065 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 555970002066 anticodon binding site; other site 555970002067 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 555970002068 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 555970002069 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 555970002070 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 555970002071 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 555970002072 catalytic site [active] 555970002073 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 555970002074 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 555970002075 Walker A/P-loop; other site 555970002076 ATP binding site [chemical binding]; other site 555970002077 Q-loop/lid; other site 555970002078 ABC transporter signature motif; other site 555970002079 Walker B; other site 555970002080 D-loop; other site 555970002081 H-loop/switch region; other site 555970002082 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 555970002083 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 555970002084 substrate binding pocket [chemical binding]; other site 555970002085 membrane-bound complex binding site; other site 555970002086 hinge residues; other site 555970002087 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970002088 dimer interface [polypeptide binding]; other site 555970002089 conserved gate region; other site 555970002090 ABC-ATPase subunit interface; other site 555970002091 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 555970002092 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970002093 dimer interface [polypeptide binding]; other site 555970002094 conserved gate region; other site 555970002095 putative PBP binding loops; other site 555970002096 ABC-ATPase subunit interface; other site 555970002097 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 555970002098 DEAD-like helicases superfamily; Region: DEXDc; smart00487 555970002099 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 555970002100 ATP binding site [chemical binding]; other site 555970002101 putative Mg++ binding site [ion binding]; other site 555970002102 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970002103 nucleotide binding region [chemical binding]; other site 555970002104 ATP-binding site [chemical binding]; other site 555970002105 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 555970002106 recombination factor protein RarA; Reviewed; Region: PRK13342 555970002107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970002108 Walker A motif; other site 555970002109 ATP binding site [chemical binding]; other site 555970002110 Walker B motif; other site 555970002111 arginine finger; other site 555970002112 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 555970002113 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970002114 putative substrate translocation pore; other site 555970002115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970002116 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 555970002117 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 555970002118 acyl-activating enzyme (AAE) consensus motif; other site 555970002119 putative AMP binding site [chemical binding]; other site 555970002120 putative active site [active] 555970002121 putative CoA binding site [chemical binding]; other site 555970002122 Transposase, Mutator family; Region: Transposase_mut; pfam00872 555970002123 MULE transposase domain; Region: MULE; pfam10551 555970002124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 555970002125 Coenzyme A binding pocket [chemical binding]; other site 555970002126 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 555970002127 hypothetical protein; Provisional; Region: PRK11770 555970002128 Domain of unknown function (DUF307); Region: DUF307; pfam03733 555970002129 Domain of unknown function (DUF307); Region: DUF307; pfam03733 555970002130 Putative transcription activator [Transcription]; Region: TenA; COG0819 555970002131 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 555970002132 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 555970002133 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 555970002134 active site 555970002135 catalytic tetrad [active] 555970002136 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 555970002137 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 555970002138 Walker A/P-loop; other site 555970002139 ATP binding site [chemical binding]; other site 555970002140 Q-loop/lid; other site 555970002141 ABC transporter signature motif; other site 555970002142 Walker B; other site 555970002143 D-loop; other site 555970002144 H-loop/switch region; other site 555970002145 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 555970002146 Walker A/P-loop; other site 555970002147 ATP binding site [chemical binding]; other site 555970002148 Q-loop/lid; other site 555970002149 ABC transporter signature motif; other site 555970002150 Walker B; other site 555970002151 D-loop; other site 555970002152 H-loop/switch region; other site 555970002153 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 555970002154 Predicted membrane protein [Function unknown]; Region: COG3601 555970002155 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 555970002156 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 555970002157 nucleotide binding site [chemical binding]; other site 555970002158 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970002159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970002160 homodimer interface [polypeptide binding]; other site 555970002161 catalytic residue [active] 555970002162 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 555970002163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970002164 Walker A/P-loop; other site 555970002165 ATP binding site [chemical binding]; other site 555970002166 Q-loop/lid; other site 555970002167 ABC transporter signature motif; other site 555970002168 Walker B; other site 555970002169 D-loop; other site 555970002170 H-loop/switch region; other site 555970002171 Ligase N family; Region: LIGANc; smart00532 555970002172 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 555970002173 nucleotide binding pocket [chemical binding]; other site 555970002174 K-X-D-G motif; other site 555970002175 catalytic site [active] 555970002176 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 555970002177 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 555970002178 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 555970002179 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 555970002180 Dimer interface [polypeptide binding]; other site 555970002181 Domain of unknown function DUF59; Region: DUF59; cl00941 555970002182 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 555970002183 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 555970002184 glutamine synthetase, type I; Region: GlnA; TIGR00653 555970002185 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 555970002186 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 555970002187 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 555970002188 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 555970002189 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 555970002190 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 555970002191 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 555970002192 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 555970002193 hypothetical protein; Provisional; Region: PRK07907 555970002194 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 555970002195 active site 555970002196 metal binding site [ion binding]; metal-binding site 555970002197 dimer interface [polypeptide binding]; other site 555970002198 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 555970002199 Histidine kinase; Region: HisKA_3; pfam07730 555970002200 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 555970002201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970002202 ABC transporter signature motif; other site 555970002203 Walker B; other site 555970002204 D-loop; other site 555970002205 H-loop/switch region; other site 555970002206 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 555970002207 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 555970002208 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 555970002209 Walker A/P-loop; other site 555970002210 ATP binding site [chemical binding]; other site 555970002211 Q-loop/lid; other site 555970002212 ABC transporter signature motif; other site 555970002213 Walker B; other site 555970002214 D-loop; other site 555970002215 H-loop/switch region; other site 555970002216 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 555970002217 Walker A/P-loop; other site 555970002218 ATP binding site [chemical binding]; other site 555970002219 Q-loop/lid; other site 555970002220 ABC transporter signature motif; other site 555970002221 Walker B; other site 555970002222 D-loop; other site 555970002223 H-loop/switch region; other site 555970002224 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 555970002225 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 555970002226 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 555970002227 Walker A/P-loop; other site 555970002228 ATP binding site [chemical binding]; other site 555970002229 Q-loop/lid; other site 555970002230 ABC transporter signature motif; other site 555970002231 Walker B; other site 555970002232 D-loop; other site 555970002233 H-loop/switch region; other site 555970002234 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 555970002235 FtsX-like permease family; Region: FtsX; pfam02687 555970002236 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 555970002237 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 555970002238 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 555970002239 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 555970002240 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 555970002241 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 555970002242 dimer interface [polypeptide binding]; other site 555970002243 motif 1; other site 555970002244 active site 555970002245 motif 2; other site 555970002246 motif 3; other site 555970002247 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 555970002248 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 555970002249 putative tRNA-binding site [nucleotide binding]; other site 555970002250 B3/4 domain; Region: B3_4; pfam03483 555970002251 tRNA synthetase B5 domain; Region: B5; smart00874 555970002252 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 555970002253 dimer interface [polypeptide binding]; other site 555970002254 motif 1; other site 555970002255 motif 3; other site 555970002256 motif 2; other site 555970002257 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 555970002258 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 555970002259 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 555970002260 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 555970002261 heterotetramer interface [polypeptide binding]; other site 555970002262 active site pocket [active] 555970002263 cleavage site 555970002264 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 555970002265 feedback inhibition sensing region; other site 555970002266 homohexameric interface [polypeptide binding]; other site 555970002267 nucleotide binding site [chemical binding]; other site 555970002268 N-acetyl-L-glutamate binding site [chemical binding]; other site 555970002269 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 555970002270 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 555970002271 inhibitor-cofactor binding pocket; inhibition site 555970002272 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970002273 catalytic residue [active] 555970002274 ornithine carbamoyltransferase; Provisional; Region: PRK00779 555970002275 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 555970002276 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 555970002277 arginine repressor; Provisional; Region: PRK03341 555970002278 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 555970002279 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 555970002280 argininosuccinate synthase; Provisional; Region: PRK13820 555970002281 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 555970002282 ANP binding site [chemical binding]; other site 555970002283 Substrate Binding Site II [chemical binding]; other site 555970002284 Substrate Binding Site I [chemical binding]; other site 555970002285 argininosuccinate lyase; Provisional; Region: PRK00855 555970002286 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 555970002287 active sites [active] 555970002288 tetramer interface [polypeptide binding]; other site 555970002289 acetoin reductases; Region: 23BDH; TIGR02415 555970002290 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 555970002291 NAD(P) binding site [chemical binding]; other site 555970002292 active site 555970002293 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 555970002294 Zn2+ binding site [ion binding]; other site 555970002295 Mg2+ binding site [ion binding]; other site 555970002296 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 555970002297 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 555970002298 active site 555970002299 HIGH motif; other site 555970002300 dimer interface [polypeptide binding]; other site 555970002301 KMSKS motif; other site 555970002302 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 555970002303 RNA binding surface [nucleotide binding]; other site 555970002304 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 555970002305 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970002306 active site 555970002307 motif I; other site 555970002308 motif II; other site 555970002309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970002310 motif II; other site 555970002311 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 555970002312 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 555970002313 RNA binding surface [nucleotide binding]; other site 555970002314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 555970002315 S-adenosylmethionine binding site [chemical binding]; other site 555970002316 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 555970002317 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 555970002318 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 555970002319 TrkA-N domain; Region: TrkA_N; pfam02254 555970002320 TrkA-C domain; Region: TrkA_C; pfam02080 555970002321 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 555970002322 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 555970002323 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 555970002324 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 555970002325 Walker A/P-loop; other site 555970002326 ATP binding site [chemical binding]; other site 555970002327 Q-loop/lid; other site 555970002328 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 555970002329 ABC transporter signature motif; other site 555970002330 Walker B; other site 555970002331 D-loop; other site 555970002332 H-loop/switch region; other site 555970002333 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 555970002334 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 555970002335 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970002336 motif II; other site 555970002337 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 555970002338 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 555970002339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970002340 catalytic residue [active] 555970002341 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 555970002342 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 555970002343 putative catalytic cysteine [active] 555970002344 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 555970002345 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 555970002346 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 555970002347 active site 555970002348 (T/H)XGH motif; other site 555970002349 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 555970002350 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 555970002351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 555970002352 active site 555970002353 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 555970002354 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 555970002355 Substrate binding site; other site 555970002356 Mg++ binding site; other site 555970002357 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 555970002358 active site 555970002359 substrate binding site [chemical binding]; other site 555970002360 CoA binding site [chemical binding]; other site 555970002361 Oligomerisation domain; Region: Oligomerisation; pfam02410 555970002362 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970002363 catalytic core [active] 555970002364 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 555970002365 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970002366 catalytic core [active] 555970002367 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 555970002368 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 555970002369 Cl binding site [ion binding]; other site 555970002370 oligomer interface [polypeptide binding]; other site 555970002371 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 555970002372 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 555970002373 substrate binding pocket [chemical binding]; other site 555970002374 membrane-bound complex binding site; other site 555970002375 hinge residues; other site 555970002376 aminoacyl-tRNA ligase; Region: PLN02563 555970002377 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 555970002378 active site 555970002379 HIGH motif; other site 555970002380 nucleotide binding site [chemical binding]; other site 555970002381 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 555970002382 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 555970002383 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 555970002384 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 555970002385 active site 555970002386 KMSKS motif; other site 555970002387 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 555970002388 tRNA binding surface [nucleotide binding]; other site 555970002389 Helix-hairpin-helix motif; Region: HHH; pfam00633 555970002390 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 555970002391 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 555970002392 Competence protein; Region: Competence; pfam03772 555970002393 hypothetical protein; Reviewed; Region: PRK07914 555970002394 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 555970002395 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 555970002396 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 555970002397 Glycoprotease family; Region: Peptidase_M22; pfam00814 555970002398 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 555970002399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 555970002400 Coenzyme A binding pocket [chemical binding]; other site 555970002401 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 555970002402 UGMP family protein; Validated; Region: PRK09604 555970002403 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 555970002404 Peptidase family M23; Region: Peptidase_M23; cl17043 555970002405 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 555970002406 isocitrate dehydrogenase; Validated; Region: PRK08299 555970002407 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 555970002408 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 555970002409 phosphate binding site [ion binding]; other site 555970002410 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 555970002411 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 555970002412 acyl-activating enzyme (AAE) consensus motif; other site 555970002413 putative AMP binding site [chemical binding]; other site 555970002414 putative active site [active] 555970002415 putative CoA binding site [chemical binding]; other site 555970002416 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 555970002417 active site 555970002418 catalytic residues [active] 555970002419 metal binding site [ion binding]; metal-binding site 555970002420 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 555970002421 rRNA interaction site [nucleotide binding]; other site 555970002422 S8 interaction site; other site 555970002423 putative laminin-1 binding site; other site 555970002424 elongation factor Ts; Provisional; Region: tsf; PRK09377 555970002425 UBA/TS-N domain; Region: UBA; pfam00627 555970002426 Elongation factor TS; Region: EF_TS; pfam00889 555970002427 Elongation factor TS; Region: EF_TS; pfam00889 555970002428 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 555970002429 putative nucleotide binding site [chemical binding]; other site 555970002430 uridine monophosphate binding site [chemical binding]; other site 555970002431 homohexameric interface [polypeptide binding]; other site 555970002432 ribosome recycling factor; Reviewed; Region: frr; PRK00083 555970002433 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 555970002434 hinge region; other site 555970002435 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 555970002436 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 555970002437 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 555970002438 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 555970002439 FeS/SAM binding site; other site 555970002440 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 555970002441 WHG domain; Region: WHG; pfam13305 555970002442 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 555970002443 Walker A/P-loop; other site 555970002444 ATP binding site [chemical binding]; other site 555970002445 ABC transporter; Region: ABC_tran; pfam00005 555970002446 Q-loop/lid; other site 555970002447 ABC transporter signature motif; other site 555970002448 Walker B; other site 555970002449 D-loop; other site 555970002450 H-loop/switch region; other site 555970002451 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 555970002452 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 555970002453 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 555970002454 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 555970002455 substrate binding site [chemical binding]; other site 555970002456 glutamase interaction surface [polypeptide binding]; other site 555970002457 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 555970002458 anthranilate synthase component I; Provisional; Region: PRK13571 555970002459 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 555970002460 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 555970002461 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 555970002462 putative uracil binding site [chemical binding]; other site 555970002463 putative active site [active] 555970002464 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 555970002465 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 555970002466 active site 555970002467 ribulose/triose binding site [chemical binding]; other site 555970002468 phosphate binding site [ion binding]; other site 555970002469 substrate (anthranilate) binding pocket [chemical binding]; other site 555970002470 product (indole) binding pocket [chemical binding]; other site 555970002471 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 555970002472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970002473 catalytic residue [active] 555970002474 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 555970002475 substrate binding site [chemical binding]; other site 555970002476 active site 555970002477 catalytic residues [active] 555970002478 heterodimer interface [polypeptide binding]; other site 555970002479 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 555970002480 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 555970002481 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 555970002482 substrate binding site [chemical binding]; other site 555970002483 hexamer interface [polypeptide binding]; other site 555970002484 metal binding site [ion binding]; metal-binding site 555970002485 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 555970002486 homodimer interface [polypeptide binding]; other site 555970002487 putative metal binding site [ion binding]; other site 555970002488 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 555970002489 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 555970002490 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 555970002491 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 555970002492 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 555970002493 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 555970002494 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 555970002495 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 555970002496 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 555970002497 phosphopeptide binding site; other site 555970002498 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 555970002499 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 555970002500 DNA binding residues [nucleotide binding] 555970002501 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 555970002502 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 555970002503 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 555970002504 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970002505 motif II; other site 555970002506 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 555970002507 DEAD-like helicases superfamily; Region: DEXDc; smart00487 555970002508 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 555970002509 ATP binding site [chemical binding]; other site 555970002510 putative Mg++ binding site [ion binding]; other site 555970002511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970002512 nucleotide binding region [chemical binding]; other site 555970002513 ATP-binding site [chemical binding]; other site 555970002514 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 555970002515 Predicted transcriptional regulator [Transcription]; Region: COG2378 555970002516 WYL domain; Region: WYL; pfam13280 555970002517 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 555970002518 active site 555970002519 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 555970002520 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 555970002521 active site 555970002522 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 555970002523 CMP-binding site; other site 555970002524 The sites determining sugar specificity; other site 555970002525 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 555970002526 G1 box; other site 555970002527 GTP/Mg2+ binding site [chemical binding]; other site 555970002528 Switch I region; other site 555970002529 G2 box; other site 555970002530 Switch II region; other site 555970002531 G3 box; other site 555970002532 G4 box; other site 555970002533 G5 box; other site 555970002534 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 555970002535 G1 box; other site 555970002536 GTP/Mg2+ binding site [chemical binding]; other site 555970002537 Switch I region; other site 555970002538 G2 box; other site 555970002539 G3 box; other site 555970002540 Switch II region; other site 555970002541 G4 box; other site 555970002542 G5 box; other site 555970002543 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 555970002544 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 555970002545 RNA binding surface [nucleotide binding]; other site 555970002546 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 555970002547 active site 555970002548 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 555970002549 amphipathic channel; other site 555970002550 Asn-Pro-Ala signature motifs; other site 555970002551 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 555970002552 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 555970002553 purine monophosphate binding site [chemical binding]; other site 555970002554 dimer interface [polypeptide binding]; other site 555970002555 putative catalytic residues [active] 555970002556 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 555970002557 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 555970002558 CoA binding domain; Region: CoA_binding; pfam02629 555970002559 CoA-ligase; Region: Ligase_CoA; pfam00549 555970002560 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 555970002561 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 555970002562 CoA-ligase; Region: Ligase_CoA; pfam00549 555970002563 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 555970002564 active site 555970002565 Preprotein translocase subunit; Region: YajC; pfam02699 555970002566 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 555970002567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970002568 Walker A motif; other site 555970002569 ATP binding site [chemical binding]; other site 555970002570 Walker B motif; other site 555970002571 arginine finger; other site 555970002572 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 555970002573 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 555970002574 RuvA N terminal domain; Region: RuvA_N; pfam01330 555970002575 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 555970002576 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 555970002577 active site 555970002578 putative DNA-binding cleft [nucleotide binding]; other site 555970002579 dimer interface [polypeptide binding]; other site 555970002580 hypothetical protein; Validated; Region: PRK00110 555970002581 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 555970002582 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 555970002583 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK07920 555970002584 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 555970002585 putative acyl-acceptor binding pocket; other site 555970002586 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 555970002587 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 555970002588 thiS-thiF/thiG interaction site; other site 555970002589 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 555970002590 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 555970002591 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 555970002592 active site 555970002593 dimer interface [polypeptide binding]; other site 555970002594 motif 1; other site 555970002595 motif 2; other site 555970002596 motif 3; other site 555970002597 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 555970002598 anticodon binding site; other site 555970002599 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 555970002600 ABC transporter; Region: ABC_tran; pfam00005 555970002601 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 555970002602 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 555970002603 Coenzyme A binding pocket [chemical binding]; other site 555970002604 PAC2 family; Region: PAC2; pfam09754 555970002605 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 555970002606 Fructosamine kinase; Region: Fructosamin_kin; cl17579 555970002607 chaperone protein DnaJ; Provisional; Region: PRK14278 555970002608 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 555970002609 HSP70 interaction site [polypeptide binding]; other site 555970002610 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 555970002611 Zn binding sites [ion binding]; other site 555970002612 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 555970002613 dimer interface [polypeptide binding]; other site 555970002614 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 555970002615 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 555970002616 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 555970002617 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 555970002618 TPP-binding site [chemical binding]; other site 555970002619 dimer interface [polypeptide binding]; other site 555970002620 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 555970002621 PYR/PP interface [polypeptide binding]; other site 555970002622 dimer interface [polypeptide binding]; other site 555970002623 TPP binding site [chemical binding]; other site 555970002624 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 555970002625 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 555970002626 putative active site [active] 555970002627 transaldolase; Provisional; Region: PRK03903 555970002628 catalytic residue [active] 555970002629 hypothetical protein; Validated; Region: PRK07682 555970002630 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970002631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970002632 homodimer interface [polypeptide binding]; other site 555970002633 catalytic residue [active] 555970002634 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 555970002635 AsnC family; Region: AsnC_trans_reg; pfam01037 555970002636 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 555970002637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 555970002638 non-specific DNA binding site [nucleotide binding]; other site 555970002639 salt bridge; other site 555970002640 sequence-specific DNA binding site [nucleotide binding]; other site 555970002641 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970002642 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970002643 homodimer interface [polypeptide binding]; other site 555970002644 catalytic residue [active] 555970002645 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 555970002646 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970002647 active site 555970002648 motif I; other site 555970002649 motif II; other site 555970002650 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970002651 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 555970002652 triosephosphate isomerase; Provisional; Region: PRK14567 555970002653 substrate binding site [chemical binding]; other site 555970002654 dimer interface [polypeptide binding]; other site 555970002655 catalytic triad [active] 555970002656 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 555970002657 Phosphoglycerate kinase; Region: PGK; pfam00162 555970002658 substrate binding site [chemical binding]; other site 555970002659 hinge regions; other site 555970002660 ADP binding site [chemical binding]; other site 555970002661 catalytic site [active] 555970002662 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 555970002663 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 555970002664 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 555970002665 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 555970002666 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 555970002667 shikimate binding site; other site 555970002668 NAD(P) binding site [chemical binding]; other site 555970002669 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 555970002670 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 555970002671 GIY-YIG motif/motif A; other site 555970002672 active site 555970002673 catalytic site [active] 555970002674 putative DNA binding site [nucleotide binding]; other site 555970002675 metal binding site [ion binding]; metal-binding site 555970002676 UvrB/uvrC motif; Region: UVR; pfam02151 555970002677 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 555970002678 Helix-hairpin-helix motif; Region: HHH; pfam00633 555970002679 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 555970002680 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 555970002681 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 555970002682 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 555970002683 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 555970002684 putative active site [active] 555970002685 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 555970002686 Predicted esterase [General function prediction only]; Region: COG0400 555970002687 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 555970002688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970002689 Walker A/P-loop; other site 555970002690 ATP binding site [chemical binding]; other site 555970002691 Q-loop/lid; other site 555970002692 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 555970002693 ABC transporter signature motif; other site 555970002694 Walker B; other site 555970002695 D-loop; other site 555970002696 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 555970002697 Cation efflux family; Region: Cation_efflux; pfam01545 555970002698 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 555970002699 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 555970002700 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 555970002701 active site 555970002702 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 555970002703 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 555970002704 putative substrate binding site [chemical binding]; other site 555970002705 putative ATP binding site [chemical binding]; other site 555970002706 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 555970002707 dimer interface [polypeptide binding]; other site 555970002708 peroxiredoxin; Region: AhpC; TIGR03137 555970002709 decamer (pentamer of dimers) interface [polypeptide binding]; other site 555970002710 catalytic triad [active] 555970002711 peroxidatic and resolving cysteines [active] 555970002712 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 555970002713 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 555970002714 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 555970002715 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 555970002716 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 555970002717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 555970002718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 555970002719 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 555970002720 dimerization interface [polypeptide binding]; other site 555970002721 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 555970002722 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970002723 motif II; other site 555970002724 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 555970002725 putative active site [active] 555970002726 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 555970002727 Predicted transcriptional regulators [Transcription]; Region: COG1733 555970002728 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 555970002729 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 555970002730 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 555970002731 Coenzyme A binding pocket [chemical binding]; other site 555970002732 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 555970002733 active site 555970002734 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 555970002735 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 555970002736 heterodimer interface [polypeptide binding]; other site 555970002737 active site 555970002738 FMN binding site [chemical binding]; other site 555970002739 homodimer interface [polypeptide binding]; other site 555970002740 substrate binding site [chemical binding]; other site 555970002741 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 555970002742 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 555970002743 FAD binding pocket [chemical binding]; other site 555970002744 FAD binding motif [chemical binding]; other site 555970002745 phosphate binding motif [ion binding]; other site 555970002746 beta-alpha-beta structure motif; other site 555970002747 NAD binding pocket [chemical binding]; other site 555970002748 Iron coordination center [ion binding]; other site 555970002749 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 555970002750 active site 555970002751 dimer interface [polypeptide binding]; other site 555970002752 dihydroorotase; Validated; Region: pyrC; PRK09357 555970002753 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 555970002754 active site 555970002755 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 555970002756 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 555970002757 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 555970002758 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 555970002759 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 555970002760 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 555970002761 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 555970002762 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 555970002763 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 555970002764 metal binding triad; other site 555970002765 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 555970002766 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 555970002767 metal binding triad; other site 555970002768 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 555970002769 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 555970002770 FAD binding site [chemical binding]; other site 555970002771 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 555970002772 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 555970002773 THF binding site; other site 555970002774 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 555970002775 substrate binding site [chemical binding]; other site 555970002776 THF binding site; other site 555970002777 zinc-binding site [ion binding]; other site 555970002778 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970002779 catalytic core [active] 555970002780 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 555970002781 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 555970002782 S-adenosylmethionine binding site [chemical binding]; other site 555970002783 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 555970002784 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970002785 Walker A/P-loop; other site 555970002786 ATP binding site [chemical binding]; other site 555970002787 Q-loop/lid; other site 555970002788 ABC transporter signature motif; other site 555970002789 Walker B; other site 555970002790 D-loop; other site 555970002791 H-loop/switch region; other site 555970002792 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 555970002793 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 555970002794 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 555970002795 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 555970002796 catalytic triad [active] 555970002797 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 555970002798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 555970002799 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 555970002800 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 555970002801 active site 555970002802 dimer interface [polypeptide binding]; other site 555970002803 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 555970002804 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 555970002805 active site 555970002806 FMN binding site [chemical binding]; other site 555970002807 substrate binding site [chemical binding]; other site 555970002808 3Fe-4S cluster binding site [ion binding]; other site 555970002809 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 555970002810 domain interface; other site 555970002811 coproporphyrinogen III oxidase; Validated; Region: PRK05628 555970002812 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 555970002813 FeS/SAM binding site; other site 555970002814 HemN C-terminal domain; Region: HemN_C; pfam06969 555970002815 GTP-binding protein LepA; Provisional; Region: PRK05433 555970002816 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 555970002817 G1 box; other site 555970002818 putative GEF interaction site [polypeptide binding]; other site 555970002819 GTP/Mg2+ binding site [chemical binding]; other site 555970002820 Switch I region; other site 555970002821 G2 box; other site 555970002822 G3 box; other site 555970002823 Switch II region; other site 555970002824 G4 box; other site 555970002825 G5 box; other site 555970002826 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 555970002827 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 555970002828 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 555970002829 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 555970002830 UPF0126 domain; Region: UPF0126; pfam03458 555970002831 Predicted membrane protein [Function unknown]; Region: COG2860 555970002832 UPF0126 domain; Region: UPF0126; pfam03458 555970002833 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 555970002834 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 555970002835 homodimer interface [polypeptide binding]; other site 555970002836 substrate-cofactor binding pocket; other site 555970002837 catalytic residue [active] 555970002838 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 555970002839 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 555970002840 5S rRNA interface [nucleotide binding]; other site 555970002841 CTC domain interface [polypeptide binding]; other site 555970002842 L16 interface [polypeptide binding]; other site 555970002843 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 555970002844 Serine hydrolase (FSH1); Region: FSH1; pfam03959 555970002845 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 555970002846 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 555970002847 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 555970002848 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 555970002849 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 555970002850 ligand binding site [chemical binding]; other site 555970002851 homodimer interface [polypeptide binding]; other site 555970002852 NAD(P) binding site [chemical binding]; other site 555970002853 trimer interface B [polypeptide binding]; other site 555970002854 trimer interface A [polypeptide binding]; other site 555970002855 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 555970002856 GTPase Era; Reviewed; Region: era; PRK00089 555970002857 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 555970002858 G1 box; other site 555970002859 GTP/Mg2+ binding site [chemical binding]; other site 555970002860 Switch I region; other site 555970002861 G2 box; other site 555970002862 Switch II region; other site 555970002863 G3 box; other site 555970002864 G4 box; other site 555970002865 G5 box; other site 555970002866 KH domain; Region: KH_2; pfam07650 555970002867 Domain of unknown function DUF21; Region: DUF21; pfam01595 555970002868 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 555970002869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 555970002870 Transporter associated domain; Region: CorC_HlyC; smart01091 555970002871 metal-binding heat shock protein; Provisional; Region: PRK00016 555970002872 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 555970002873 PhoH-like protein; Region: PhoH; pfam02562 555970002874 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 555970002875 nucleotide binding site/active site [active] 555970002876 HIT family signature motif; other site 555970002877 catalytic residue [active] 555970002878 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 555970002879 RNA methyltransferase, RsmE family; Region: TIGR00046 555970002880 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 555970002881 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 555970002882 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 555970002883 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 555970002884 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 555970002885 ligand binding site; other site 555970002886 oligomer interface; other site 555970002887 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 555970002888 dimer interface [polypeptide binding]; other site 555970002889 N-terminal domain interface [polypeptide binding]; other site 555970002890 sulfate 1 binding site; other site 555970002891 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 555970002892 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 555970002893 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 555970002894 trimerization site [polypeptide binding]; other site 555970002895 active site 555970002896 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 555970002897 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 555970002898 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 555970002899 catalytic residue [active] 555970002900 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 555970002901 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 555970002902 Walker A/P-loop; other site 555970002903 ATP binding site [chemical binding]; other site 555970002904 Q-loop/lid; other site 555970002905 ABC transporter signature motif; other site 555970002906 Walker B; other site 555970002907 D-loop; other site 555970002908 H-loop/switch region; other site 555970002909 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 555970002910 FeS assembly protein SufD; Region: sufD; TIGR01981 555970002911 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 555970002912 FeS assembly protein SufB; Region: sufB; TIGR01980 555970002913 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 555970002914 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 555970002915 CTP synthetase; Validated; Region: pyrG; PRK05380 555970002916 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 555970002917 active site 555970002918 UTP binding site [chemical binding]; other site 555970002919 Catalytic site [active] 555970002920 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 555970002921 active site 555970002922 putative oxyanion hole; other site 555970002923 catalytic triad [active] 555970002924 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 555970002925 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 555970002926 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 555970002927 potential frameshift: common BLAST hit:gi|119025726|ref|YP_909571.1| pullulanase 555970002928 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 555970002929 catalytic nucleophile [active] 555970002930 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 555970002931 GIY-YIG motif/motif A; other site 555970002932 putative active site [active] 555970002933 putative metal binding site [ion binding]; other site 555970002934 Dehydroquinase class II; Region: DHquinase_II; pfam01220 555970002935 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 555970002936 trimer interface [polypeptide binding]; other site 555970002937 active site 555970002938 dimer interface [polypeptide binding]; other site 555970002939 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 555970002940 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 555970002941 ADP binding site [chemical binding]; other site 555970002942 magnesium binding site [ion binding]; other site 555970002943 putative shikimate binding site; other site 555970002944 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 555970002945 active site 555970002946 dimer interface [polypeptide binding]; other site 555970002947 metal binding site [ion binding]; metal-binding site 555970002948 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 555970002949 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 555970002950 Tetramer interface [polypeptide binding]; other site 555970002951 active site 555970002952 FMN-binding site [chemical binding]; other site 555970002953 YceG-like family; Region: YceG; pfam02618 555970002954 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 555970002955 dimerization interface [polypeptide binding]; other site 555970002956 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 555970002957 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 555970002958 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 555970002959 motif 1; other site 555970002960 active site 555970002961 motif 2; other site 555970002962 motif 3; other site 555970002963 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 555970002964 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970002965 catalytic core [active] 555970002966 Membrane protein of unknown function; Region: DUF360; pfam04020 555970002967 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 555970002968 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 555970002969 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 555970002970 RNA binding surface [nucleotide binding]; other site 555970002971 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 555970002972 Part of AAA domain; Region: AAA_19; pfam13245 555970002973 Family description; Region: UvrD_C_2; pfam13538 555970002974 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 555970002975 active site 555970002976 xanthine permease; Region: pbuX; TIGR03173 555970002977 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 555970002978 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 555970002979 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970002980 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970002981 homodimer interface [polypeptide binding]; other site 555970002982 catalytic residue [active] 555970002983 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 555970002984 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 555970002985 active site 555970002986 Na/Ca binding site [ion binding]; other site 555970002987 catalytic site [active] 555970002988 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 555970002989 Peptidase C26; Region: Peptidase_C26; pfam07722 555970002990 catalytic triad [active] 555970002991 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 555970002992 putative deacylase active site [active] 555970002993 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 555970002994 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 555970002995 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 555970002996 Walker A/P-loop; other site 555970002997 ATP binding site [chemical binding]; other site 555970002998 Q-loop/lid; other site 555970002999 ABC transporter signature motif; other site 555970003000 Walker B; other site 555970003001 D-loop; other site 555970003002 H-loop/switch region; other site 555970003003 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 555970003004 DNA-binding site [nucleotide binding]; DNA binding site 555970003005 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 555970003006 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 555970003007 non-specific DNA binding site [nucleotide binding]; other site 555970003008 salt bridge; other site 555970003009 sequence-specific DNA binding site [nucleotide binding]; other site 555970003010 adenosine deaminase; Provisional; Region: PRK09358 555970003011 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 555970003012 active site 555970003013 Chorismate mutase type II; Region: CM_2; cl00693 555970003014 hypothetical protein; Provisional; Region: PRK06761 555970003015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 555970003016 Coenzyme A binding pocket [chemical binding]; other site 555970003017 AAA domain; Region: AAA_17; pfam13207 555970003018 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 555970003019 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 555970003020 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 555970003021 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 555970003022 G1 box; other site 555970003023 putative GEF interaction site [polypeptide binding]; other site 555970003024 GTP/Mg2+ binding site [chemical binding]; other site 555970003025 Switch I region; other site 555970003026 G2 box; other site 555970003027 G3 box; other site 555970003028 Switch II region; other site 555970003029 G4 box; other site 555970003030 G5 box; other site 555970003031 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 555970003032 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 555970003033 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 555970003034 Transposase domain (DUF772); Region: DUF772; pfam05598 555970003035 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 555970003036 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 555970003037 GMP synthase; Reviewed; Region: guaA; PRK00074 555970003038 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 555970003039 AMP/PPi binding site [chemical binding]; other site 555970003040 candidate oxyanion hole; other site 555970003041 catalytic triad [active] 555970003042 potential glutamine specificity residues [chemical binding]; other site 555970003043 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 555970003044 ATP Binding subdomain [chemical binding]; other site 555970003045 Ligand Binding sites [chemical binding]; other site 555970003046 Dimerization subdomain; other site 555970003047 putative phosphoketolase; Provisional; Region: PRK05261 555970003048 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 555970003049 TPP-binding site; other site 555970003050 XFP C-terminal domain; Region: XFP_C; pfam09363 555970003051 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 555970003052 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 555970003053 propionate/acetate kinase; Provisional; Region: PRK12379 555970003054 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 555970003055 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 555970003056 hinge; other site 555970003057 active site 555970003058 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 555970003059 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 555970003060 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 555970003061 active site 555970003062 catalytic site [active] 555970003063 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 555970003064 dimer interface [polypeptide binding]; other site 555970003065 ADP-ribose binding site [chemical binding]; other site 555970003066 active site 555970003067 nudix motif; other site 555970003068 metal binding site [ion binding]; metal-binding site 555970003069 Uncharacterized conserved protein [Function unknown]; Region: COG0327 555970003070 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 555970003071 DNA polymerase I; Provisional; Region: PRK05755 555970003072 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 555970003073 active site 555970003074 metal binding site 1 [ion binding]; metal-binding site 555970003075 putative 5' ssDNA interaction site; other site 555970003076 metal binding site 3; metal-binding site 555970003077 metal binding site 2 [ion binding]; metal-binding site 555970003078 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 555970003079 putative DNA binding site [nucleotide binding]; other site 555970003080 putative metal binding site [ion binding]; other site 555970003081 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 555970003082 active site 555970003083 substrate binding site [chemical binding]; other site 555970003084 catalytic site [active] 555970003085 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 555970003086 active site 555970003087 DNA binding site [nucleotide binding] 555970003088 catalytic site [active] 555970003089 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 555970003090 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 555970003091 active site 555970003092 phosphorylation site [posttranslational modification] 555970003093 intermolecular recognition site; other site 555970003094 dimerization interface [polypeptide binding]; other site 555970003095 ANTAR domain; Region: ANTAR; pfam03861 555970003096 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 555970003097 dimer interface [polypeptide binding]; other site 555970003098 ADP-ribose binding site [chemical binding]; other site 555970003099 active site 555970003100 nudix motif; other site 555970003101 metal binding site [ion binding]; metal-binding site 555970003102 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 555970003103 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 555970003104 active site 555970003105 domain interfaces; other site 555970003106 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 555970003107 excinuclease ABC subunit B; Provisional; Region: PRK05298 555970003108 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 555970003109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970003110 nucleotide binding region [chemical binding]; other site 555970003111 ATP-binding site [chemical binding]; other site 555970003112 Ultra-violet resistance protein B; Region: UvrB; pfam12344 555970003113 UvrB/uvrC motif; Region: UVR; pfam02151 555970003114 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 555970003115 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 555970003116 CoA-binding site [chemical binding]; other site 555970003117 ATP-binding [chemical binding]; other site 555970003118 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 555970003119 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 555970003120 RNA binding site [nucleotide binding]; other site 555970003121 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 555970003122 RNA binding site [nucleotide binding]; other site 555970003123 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 555970003124 RNA binding site [nucleotide binding]; other site 555970003125 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 555970003126 RNA binding site [nucleotide binding]; other site 555970003127 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 555970003128 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 555970003129 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 555970003130 homodimer interface [polypeptide binding]; other site 555970003131 NADP binding site [chemical binding]; other site 555970003132 substrate binding site [chemical binding]; other site 555970003133 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 555970003134 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 555970003135 intersubunit interface [polypeptide binding]; other site 555970003136 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 555970003137 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 555970003138 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 555970003139 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 555970003140 ABC-ATPase subunit interface; other site 555970003141 dimer interface [polypeptide binding]; other site 555970003142 putative PBP binding regions; other site 555970003143 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 555970003144 homotrimer interaction site [polypeptide binding]; other site 555970003145 zinc binding site [ion binding]; other site 555970003146 CDP-binding sites; other site 555970003147 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 555970003148 glycogen branching enzyme; Provisional; Region: PRK05402 555970003149 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 555970003150 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 555970003151 active site 555970003152 catalytic site [active] 555970003153 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 555970003154 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 555970003155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 555970003156 active site 555970003157 phosphorylation site [posttranslational modification] 555970003158 intermolecular recognition site; other site 555970003159 dimerization interface [polypeptide binding]; other site 555970003160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 555970003161 DNA binding site [nucleotide binding] 555970003162 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 555970003163 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 555970003164 dimerization interface [polypeptide binding]; other site 555970003165 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 555970003166 dimer interface [polypeptide binding]; other site 555970003167 phosphorylation site [posttranslational modification] 555970003168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 555970003169 ATP binding site [chemical binding]; other site 555970003170 Mg2+ binding site [ion binding]; other site 555970003171 G-X-G motif; other site 555970003172 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 555970003173 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 555970003174 active site 555970003175 Eukaryotic phosphomannomutase; Region: PMM; cl17107 555970003176 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 555970003177 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 555970003178 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 555970003179 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 555970003180 Transcriptional regulator [Transcription]; Region: LytR; COG1316 555970003181 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 555970003182 Transcription factor WhiB; Region: Whib; pfam02467 555970003183 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 555970003184 PAS fold; Region: PAS_4; pfam08448 555970003185 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 555970003186 Histidine kinase; Region: HisKA_2; pfam07568 555970003187 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 555970003188 ATP binding site [chemical binding]; other site 555970003189 Mg2+ binding site [ion binding]; other site 555970003190 G-X-G motif; other site 555970003191 V-type ATP synthase subunit E; Provisional; Region: PRK01558 555970003192 Haemolysin-III related; Region: HlyIII; pfam03006 555970003193 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 555970003194 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 555970003195 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 555970003196 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 555970003197 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 555970003198 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 555970003199 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 555970003200 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 555970003201 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 555970003202 Protein of unknown function (DUF501); Region: DUF501; pfam04417 555970003203 Septum formation initiator; Region: DivIC; pfam04977 555970003204 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 555970003205 enolase; Provisional; Region: eno; PRK00077 555970003206 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 555970003207 dimer interface [polypeptide binding]; other site 555970003208 metal binding site [ion binding]; metal-binding site 555970003209 substrate binding pocket [chemical binding]; other site 555970003210 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 555970003211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970003212 dimer interface [polypeptide binding]; other site 555970003213 conserved gate region; other site 555970003214 putative PBP binding loops; other site 555970003215 ABC-ATPase subunit interface; other site 555970003216 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 555970003217 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 555970003218 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 555970003219 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 555970003220 Walker A/P-loop; other site 555970003221 ATP binding site [chemical binding]; other site 555970003222 Q-loop/lid; other site 555970003223 ABC transporter signature motif; other site 555970003224 Walker B; other site 555970003225 D-loop; other site 555970003226 H-loop/switch region; other site 555970003227 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 555970003228 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 555970003229 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 555970003230 ATP binding site [chemical binding]; other site 555970003231 putative Mg++ binding site [ion binding]; other site 555970003232 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970003233 nucleotide binding region [chemical binding]; other site 555970003234 ATP-binding site [chemical binding]; other site 555970003235 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 555970003236 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 555970003237 putative active site [active] 555970003238 catalytic residue [active] 555970003239 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 555970003240 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 555970003241 Coenzyme A binding pocket [chemical binding]; other site 555970003242 Uncharacterized conserved protein [Function unknown]; Region: COG1615 555970003243 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 555970003244 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 555970003245 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 555970003246 Protein of unknown function (DUF466); Region: DUF466; cl01082 555970003247 carbon starvation protein A; Provisional; Region: PRK15015 555970003248 Carbon starvation protein CstA; Region: CstA; pfam02554 555970003249 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 555970003250 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970003251 H-loop/switch region; other site 555970003252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970003253 ABC transporter signature motif; other site 555970003254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 555970003255 Q-loop/lid; other site 555970003256 ABC transporter signature motif; other site 555970003257 Walker B; other site 555970003258 D-loop; other site 555970003259 H-loop/switch region; other site 555970003260 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 555970003261 MarR family; Region: MarR_2; pfam12802 555970003262 Ubinuclein conserved middle domain; Region: UBN_AB; pfam14075 555970003263 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 555970003264 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 555970003265 Aspartase; Region: Aspartase; cd01357 555970003266 active sites [active] 555970003267 tetramer interface [polypeptide binding]; other site 555970003268 FeoA domain; Region: FeoA; pfam04023 555970003269 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 555970003270 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 555970003271 G1 box; other site 555970003272 GTP/Mg2+ binding site [chemical binding]; other site 555970003273 Switch I region; other site 555970003274 G2 box; other site 555970003275 G3 box; other site 555970003276 Switch II region; other site 555970003277 G4 box; other site 555970003278 G5 box; other site 555970003279 Nucleoside recognition; Region: Gate; pfam07670 555970003280 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 555970003281 Nucleoside recognition; Region: Gate; pfam07670 555970003282 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 555970003283 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 555970003284 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 555970003285 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 555970003286 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 555970003287 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 555970003288 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 555970003289 putative active site [active] 555970003290 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 555970003291 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 555970003292 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 555970003293 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 555970003294 catalytic triad [active] 555970003295 active site nucleophile [active] 555970003296 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 555970003297 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 555970003298 SelR domain; Region: SelR; pfam01641 555970003299 methionine sulfoxide reductase B; Provisional; Region: PRK00222 555970003300 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 555970003301 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 555970003302 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 555970003303 Soluble P-type ATPase [General function prediction only]; Region: COG4087 555970003304 Uncharacterized conserved protein [Function unknown]; Region: COG3350 555970003305 classical (c) SDRs; Region: SDR_c; cd05233 555970003306 NAD(P) binding site [chemical binding]; other site 555970003307 active site 555970003308 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 555970003309 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 555970003310 ATP binding site [chemical binding]; other site 555970003311 Mg++ binding site [ion binding]; other site 555970003312 motif III; other site 555970003313 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970003314 nucleotide binding region [chemical binding]; other site 555970003315 ATP-binding site [chemical binding]; other site 555970003316 Predicted membrane protein [Function unknown]; Region: COG2855 555970003317 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 555970003318 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 555970003319 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 555970003320 substrate binding pocket [chemical binding]; other site 555970003321 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 555970003322 GTP-binding protein YchF; Reviewed; Region: PRK09601 555970003323 YchF GTPase; Region: YchF; cd01900 555970003324 G1 box; other site 555970003325 GTP/Mg2+ binding site [chemical binding]; other site 555970003326 Switch I region; other site 555970003327 G2 box; other site 555970003328 Switch II region; other site 555970003329 G3 box; other site 555970003330 G4 box; other site 555970003331 G5 box; other site 555970003332 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 555970003333 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 555970003334 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 555970003335 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 555970003336 Histidine kinase; Region: HisKA_3; pfam07730 555970003337 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 555970003338 ATP binding site [chemical binding]; other site 555970003339 Mg2+ binding site [ion binding]; other site 555970003340 G-X-G motif; other site 555970003341 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 555970003342 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 555970003343 active site 555970003344 phosphorylation site [posttranslational modification] 555970003345 intermolecular recognition site; other site 555970003346 dimerization interface [polypeptide binding]; other site 555970003347 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 555970003348 DNA binding residues [nucleotide binding] 555970003349 dimerization interface [polypeptide binding]; other site 555970003350 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 555970003351 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 555970003352 FtsX-like permease family; Region: FtsX; pfam02687 555970003353 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 555970003354 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 555970003355 Walker A/P-loop; other site 555970003356 ATP binding site [chemical binding]; other site 555970003357 Q-loop/lid; other site 555970003358 ABC transporter signature motif; other site 555970003359 Walker B; other site 555970003360 D-loop; other site 555970003361 H-loop/switch region; other site 555970003362 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 555970003363 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 555970003364 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 555970003365 Walker A/P-loop; other site 555970003366 ATP binding site [chemical binding]; other site 555970003367 Q-loop/lid; other site 555970003368 ABC transporter signature motif; other site 555970003369 Walker B; other site 555970003370 D-loop; other site 555970003371 H-loop/switch region; other site 555970003372 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 555970003373 Walker A/P-loop; other site 555970003374 ATP binding site [chemical binding]; other site 555970003375 Q-loop/lid; other site 555970003376 ABC transporter signature motif; other site 555970003377 Walker B; other site 555970003378 D-loop; other site 555970003379 H-loop/switch region; other site 555970003380 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 555970003381 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 555970003382 homodimer interface [polypeptide binding]; other site 555970003383 substrate-cofactor binding pocket; other site 555970003384 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970003385 catalytic residue [active] 555970003386 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 555970003387 dimer interface [polypeptide binding]; other site 555970003388 pyridoxal binding site [chemical binding]; other site 555970003389 ATP binding site [chemical binding]; other site 555970003390 hypothetical protein; Provisional; Region: PRK14681 555970003391 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 555970003392 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 555970003393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970003394 Walker A motif; other site 555970003395 ATP binding site [chemical binding]; other site 555970003396 Walker B motif; other site 555970003397 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 555970003398 DNA protecting protein DprA; Region: dprA; TIGR00732 555970003399 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 555970003400 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 555970003401 L-aspartate oxidase; Provisional; Region: PRK06175 555970003402 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 555970003403 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 555970003404 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 555970003405 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 555970003406 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 555970003407 S-adenosylmethionine binding site [chemical binding]; other site 555970003408 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 555970003409 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 555970003410 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 555970003411 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970003412 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970003413 homodimer interface [polypeptide binding]; other site 555970003414 catalytic residue [active] 555970003415 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 555970003416 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 555970003417 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970003418 Walker A motif; other site 555970003419 ATP binding site [chemical binding]; other site 555970003420 Walker B motif; other site 555970003421 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 555970003422 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 555970003423 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 555970003424 oligomer interface [polypeptide binding]; other site 555970003425 active site residues [active] 555970003426 Clp protease; Region: CLP_protease; pfam00574 555970003427 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 555970003428 oligomer interface [polypeptide binding]; other site 555970003429 active site residues [active] 555970003430 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 555970003431 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 555970003432 putative ion selectivity filter; other site 555970003433 putative pore gating glutamate residue; other site 555970003434 trigger factor; Provisional; Region: tig; PRK01490 555970003435 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 555970003436 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 555970003437 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 555970003438 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 555970003439 active site 555970003440 catalytic site [active] 555970003441 substrate binding site [chemical binding]; other site 555970003442 HRDC domain; Region: HRDC; pfam00570 555970003443 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 555970003444 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 555970003445 FeS/SAM binding site; other site 555970003446 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 555970003447 Pyruvate formate lyase 1; Region: PFL1; cd01678 555970003448 coenzyme A binding site [chemical binding]; other site 555970003449 active site 555970003450 catalytic residues [active] 555970003451 glycine loop; other site 555970003452 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 555970003453 NAD synthetase; Provisional; Region: PRK13981 555970003454 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 555970003455 multimer interface [polypeptide binding]; other site 555970003456 active site 555970003457 catalytic triad [active] 555970003458 protein interface 1 [polypeptide binding]; other site 555970003459 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 555970003460 homodimer interface [polypeptide binding]; other site 555970003461 NAD binding pocket [chemical binding]; other site 555970003462 ATP binding pocket [chemical binding]; other site 555970003463 Mg binding site [ion binding]; other site 555970003464 active-site loop [active] 555970003465 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 555970003466 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 555970003467 metal binding site [ion binding]; metal-binding site 555970003468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970003469 conserved gate region; other site 555970003470 ABC-ATPase subunit interface; other site 555970003471 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 555970003472 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 555970003473 Walker A/P-loop; other site 555970003474 ATP binding site [chemical binding]; other site 555970003475 Q-loop/lid; other site 555970003476 ABC transporter signature motif; other site 555970003477 Walker B; other site 555970003478 D-loop; other site 555970003479 H-loop/switch region; other site 555970003480 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 555970003481 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 555970003482 active site 555970003483 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 555970003484 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 555970003485 Zn2+ binding site [ion binding]; other site 555970003486 Mg2+ binding site [ion binding]; other site 555970003487 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 555970003488 synthetase active site [active] 555970003489 NTP binding site [chemical binding]; other site 555970003490 metal binding site [ion binding]; metal-binding site 555970003491 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 555970003492 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 555970003493 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 555970003494 trimer interface [polypeptide binding]; other site 555970003495 active site 555970003496 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 555970003497 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 555970003498 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 555970003499 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 555970003500 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 555970003501 CAP-like domain; other site 555970003502 active site 555970003503 primary dimer interface [polypeptide binding]; other site 555970003504 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 555970003505 EamA-like transporter family; Region: EamA; cl17759 555970003506 DEAD-like helicases superfamily; Region: DEXDc; smart00487 555970003507 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 555970003508 ATP binding site [chemical binding]; other site 555970003509 putative Mg++ binding site [ion binding]; other site 555970003510 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 555970003511 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970003512 nucleotide binding region [chemical binding]; other site 555970003513 ATP-binding site [chemical binding]; other site 555970003514 DEAD/H associated; Region: DEAD_assoc; pfam08494 555970003515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970003516 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970003517 putative substrate translocation pore; other site 555970003518 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 555970003519 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 555970003520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 555970003521 ATP binding site [chemical binding]; other site 555970003522 Mg2+ binding site [ion binding]; other site 555970003523 G-X-G motif; other site 555970003524 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 555970003525 anchoring element; other site 555970003526 dimer interface [polypeptide binding]; other site 555970003527 ATP binding site [chemical binding]; other site 555970003528 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 555970003529 active site 555970003530 putative metal-binding site [ion binding]; other site 555970003531 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 555970003532 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 555970003533 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 555970003534 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 555970003535 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 555970003536 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 555970003537 DNA binding residues [nucleotide binding] 555970003538 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 555970003539 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 555970003540 substrate binding pocket [chemical binding]; other site 555970003541 chain length determination region; other site 555970003542 substrate-Mg2+ binding site; other site 555970003543 catalytic residues [active] 555970003544 aspartate-rich region 1; other site 555970003545 active site lid residues [active] 555970003546 aspartate-rich region 2; other site 555970003547 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 555970003548 Catalytic domain of Protein Kinases; Region: PKc; cd00180 555970003549 active site 555970003550 ATP binding site [chemical binding]; other site 555970003551 substrate binding site [chemical binding]; other site 555970003552 activation loop (A-loop); other site 555970003553 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 555970003554 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 555970003555 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 555970003556 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 555970003557 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 555970003558 putative acyl-acceptor binding pocket; other site 555970003559 TrbC/VIRB2 family; Region: TrbC; pfam04956 555970003560 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 555970003561 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 555970003562 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 555970003563 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 555970003564 DEAD/DEAH box helicase; Region: DEAD; pfam00270 555970003565 ATP binding site [chemical binding]; other site 555970003566 putative Mg++ binding site [ion binding]; other site 555970003567 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 555970003568 SEC-C motif; Region: SEC-C; pfam02810 555970003569 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 555970003570 30S subunit binding site; other site 555970003571 RecX family; Region: RecX; pfam02631 555970003572 recombinase A; Provisional; Region: recA; PRK09354 555970003573 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 555970003574 hexamer interface [polypeptide binding]; other site 555970003575 Walker A motif; other site 555970003576 ATP binding site [chemical binding]; other site 555970003577 Walker B motif; other site 555970003578 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 555970003579 Competence-damaged protein; Region: CinA; pfam02464 555970003580 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 555970003581 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 555970003582 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 555970003583 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 555970003584 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 555970003585 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 555970003586 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 555970003587 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 555970003588 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 555970003589 FeS/SAM binding site; other site 555970003590 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 555970003591 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 555970003592 synthetase active site [active] 555970003593 NTP binding site [chemical binding]; other site 555970003594 metal binding site [ion binding]; metal-binding site 555970003595 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 555970003596 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 555970003597 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 555970003598 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 555970003599 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 555970003600 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 555970003601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970003602 Walker A/P-loop; other site 555970003603 ATP binding site [chemical binding]; other site 555970003604 Q-loop/lid; other site 555970003605 ABC transporter signature motif; other site 555970003606 Walker B; other site 555970003607 D-loop; other site 555970003608 H-loop/switch region; other site 555970003609 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 555970003610 Histidine kinase; Region: HisKA_3; pfam07730 555970003611 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 555970003612 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 555970003613 active site 555970003614 phosphorylation site [posttranslational modification] 555970003615 intermolecular recognition site; other site 555970003616 dimerization interface [polypeptide binding]; other site 555970003617 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 555970003618 DNA binding residues [nucleotide binding] 555970003619 dimerization interface [polypeptide binding]; other site 555970003620 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 555970003621 Transposase; Region: DDE_Tnp_ISL3; pfam01610 555970003622 Protein of unknown function DUF262; Region: DUF262; pfam03235 555970003623 Uncharacterized conserved protein [Function unknown]; Region: COG1479 555970003624 Protein of unknown function DUF262; Region: DUF262; pfam03235 555970003625 maltose O-acetyltransferase; Provisional; Region: PRK10092 555970003626 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 555970003627 active site 555970003628 substrate binding site [chemical binding]; other site 555970003629 trimer interface [polypeptide binding]; other site 555970003630 CoA binding site [chemical binding]; other site 555970003631 aconitate hydratase; Validated; Region: PRK09277 555970003632 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 555970003633 substrate binding site [chemical binding]; other site 555970003634 ligand binding site [chemical binding]; other site 555970003635 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 555970003636 substrate binding site [chemical binding]; other site 555970003637 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 555970003638 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 555970003639 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 555970003640 Soluble P-type ATPase [General function prediction only]; Region: COG4087 555970003641 Protein of unknown function (DUF418); Region: DUF418; cl12135 555970003642 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 555970003643 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 555970003644 TRAM domain; Region: TRAM; cl01282 555970003645 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 555970003646 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 555970003647 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 555970003648 putative active site [active] 555970003649 putative catalytic site [active] 555970003650 putative DNA binding site [nucleotide binding]; other site 555970003651 putative phosphate binding site [ion binding]; other site 555970003652 metal binding site A [ion binding]; metal-binding site 555970003653 putative AP binding site [nucleotide binding]; other site 555970003654 putative metal binding site B [ion binding]; other site 555970003655 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 555970003656 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 555970003657 AAA domain; Region: AAA_21; pfam13304 555970003658 Walker A/P-loop; other site 555970003659 ATP binding site [chemical binding]; other site 555970003660 Q-loop/lid; other site 555970003661 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 555970003662 ABC transporter signature motif; other site 555970003663 Walker B; other site 555970003664 D-loop; other site 555970003665 H-loop/switch region; other site 555970003666 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 555970003667 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 555970003668 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 555970003669 Walker A/P-loop; other site 555970003670 ATP binding site [chemical binding]; other site 555970003671 Q-loop/lid; other site 555970003672 ABC transporter signature motif; other site 555970003673 Walker B; other site 555970003674 D-loop; other site 555970003675 H-loop/switch region; other site 555970003676 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 555970003677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970003678 dimer interface [polypeptide binding]; other site 555970003679 conserved gate region; other site 555970003680 putative PBP binding loops; other site 555970003681 ABC-ATPase subunit interface; other site 555970003682 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 555970003683 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970003684 dimer interface [polypeptide binding]; other site 555970003685 conserved gate region; other site 555970003686 putative PBP binding loops; other site 555970003687 ABC-ATPase subunit interface; other site 555970003688 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 555970003689 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 555970003690 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 555970003691 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 555970003692 active site 555970003693 DNA binding site [nucleotide binding] 555970003694 Int/Topo IB signature motif; other site 555970003695 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 555970003696 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 555970003697 Walker A/P-loop; other site 555970003698 ATP binding site [chemical binding]; other site 555970003699 Q-loop/lid; other site 555970003700 ABC transporter signature motif; other site 555970003701 Walker B; other site 555970003702 D-loop; other site 555970003703 H-loop/switch region; other site 555970003704 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 555970003705 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 555970003706 FtsX-like permease family; Region: FtsX; pfam02687 555970003707 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 555970003708 FtsX-like permease family; Region: FtsX; pfam02687 555970003709 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 555970003710 prephenate dehydrogenase; Validated; Region: PRK08507 555970003711 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 555970003712 Prephenate dehydratase; Region: PDT; pfam00800 555970003713 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 555970003714 putative L-Phe binding site [chemical binding]; other site 555970003715 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 555970003716 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 555970003717 G1 box; other site 555970003718 putative GEF interaction site [polypeptide binding]; other site 555970003719 GTP/Mg2+ binding site [chemical binding]; other site 555970003720 Switch I region; other site 555970003721 G2 box; other site 555970003722 G3 box; other site 555970003723 Switch II region; other site 555970003724 G4 box; other site 555970003725 G5 box; other site 555970003726 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 555970003727 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 555970003728 benzoate transport; Region: 2A0115; TIGR00895 555970003729 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970003730 putative substrate translocation pore; other site 555970003731 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 555970003732 nudix motif; other site 555970003733 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 555970003734 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 555970003735 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 555970003736 P-loop; other site 555970003737 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 555970003738 Magnesium ion binding site [ion binding]; other site 555970003739 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 555970003740 Magnesium ion binding site [ion binding]; other site 555970003741 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 555970003742 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 555970003743 active site 555970003744 Int/Topo IB signature motif; other site 555970003745 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 555970003746 23S rRNA binding site [nucleotide binding]; other site 555970003747 L21 binding site [polypeptide binding]; other site 555970003748 L13 binding site [polypeptide binding]; other site 555970003749 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 555970003750 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 555970003751 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 555970003752 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 555970003753 Thiamine pyrophosphokinase; Region: TPK; cd07995 555970003754 active site 555970003755 dimerization interface [polypeptide binding]; other site 555970003756 thiamine binding site [chemical binding]; other site 555970003757 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 555970003758 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 555970003759 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 555970003760 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 555970003761 putative deacylase active site [active] 555970003762 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 555970003763 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 555970003764 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 555970003765 active site 555970003766 catalytic residues [active] 555970003767 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 555970003768 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 555970003769 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 555970003770 DNA binding residues [nucleotide binding] 555970003771 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 555970003772 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 555970003773 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 555970003774 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 555970003775 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 555970003776 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 555970003777 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 555970003778 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 555970003779 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 555970003780 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 555970003781 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 555970003782 active site 555970003783 phosphorylation site [posttranslational modification] 555970003784 intermolecular recognition site; other site 555970003785 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 555970003786 DNA binding residues [nucleotide binding] 555970003787 dimerization interface [polypeptide binding]; other site 555970003788 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 555970003789 Histidine kinase; Region: HisKA_3; pfam07730 555970003790 Helix-hairpin-helix class 2 (Pol1 family) motif. HhH2 domains are found in Rad2 family of prokaryotic and eukaryotic replication and repair nucleases, i.e., DNA polymerase I, Taq DNA polymerase, DNA repair protein Rad2 endonuclease, flap endonuclease...; Region: HhH2_motif; cl00079 555970003791 metal binding site I; metal-binding site 555970003792 metal binding site II; metal-binding site 555970003793 proline aminopeptidase P II; Provisional; Region: PRK10879 555970003794 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 555970003795 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 555970003796 active site 555970003797 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 555970003798 nudix motif; other site 555970003799 MarR family; Region: MarR_2; cl17246 555970003800 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 555970003801 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 555970003802 nucleotide binding site [chemical binding]; other site 555970003803 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 555970003804 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 555970003805 putative substrate binding site [chemical binding]; other site 555970003806 putative ATP binding site [chemical binding]; other site 555970003807 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 555970003808 putative active site [active] 555970003809 dimerization interface [polypeptide binding]; other site 555970003810 putative tRNAtyr binding site [nucleotide binding]; other site 555970003811 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 555970003812 active site 555970003813 DNA binding site [nucleotide binding] 555970003814 Int/Topo IB signature motif; other site 555970003815 Helix-turn-helix domain; Region: HTH_17; pfam12728 555970003816 Helix-turn-helix domain; Region: HTH_17; pfam12728 555970003817 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 555970003818 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 555970003819 Walker A motif; other site 555970003820 ATP binding site [chemical binding]; other site 555970003821 Walker B motif; other site 555970003822 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 555970003823 Phage capsid family; Region: Phage_capsid; pfam05065 555970003824 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 555970003825 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 555970003826 Walker A/P-loop; other site 555970003827 ATP binding site [chemical binding]; other site 555970003828 Q-loop/lid; other site 555970003829 ABC transporter signature motif; other site 555970003830 Walker B; other site 555970003831 D-loop; other site 555970003832 H-loop/switch region; other site 555970003833 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 555970003834 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 555970003835 Walker A/P-loop; other site 555970003836 ATP binding site [chemical binding]; other site 555970003837 Q-loop/lid; other site 555970003838 ABC transporter signature motif; other site 555970003839 Walker B; other site 555970003840 D-loop; other site 555970003841 H-loop/switch region; other site 555970003842 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 555970003843 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 555970003844 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 555970003845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970003846 dimer interface [polypeptide binding]; other site 555970003847 conserved gate region; other site 555970003848 ABC-ATPase subunit interface; other site 555970003849 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 555970003850 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970003851 dimer interface [polypeptide binding]; other site 555970003852 conserved gate region; other site 555970003853 putative PBP binding loops; other site 555970003854 ABC-ATPase subunit interface; other site 555970003855 potential frameshift: common BLAST hit:gi|189439074|ref|YP_001954155.1| ABC-type dipeptidetransport system periplasmic component 555970003856 cell division protein FtsQ; Provisional; Region: PRK05529 555970003857 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 555970003858 Cell division protein FtsQ; Region: FtsQ; pfam03799 555970003859 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 555970003860 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 555970003861 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 555970003862 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 555970003863 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 555970003864 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 555970003865 active site 555970003866 homodimer interface [polypeptide binding]; other site 555970003867 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 555970003868 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 555970003869 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 555970003870 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 555970003871 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 555970003872 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 555970003873 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 555970003874 Mg++ binding site [ion binding]; other site 555970003875 putative catalytic motif [active] 555970003876 putative substrate binding site [chemical binding]; other site 555970003877 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 555970003878 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 555970003879 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 555970003880 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 555970003881 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 555970003882 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 555970003883 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 555970003884 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 555970003885 MraW methylase family; Region: Methyltransf_5; cl17771 555970003886 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 555970003887 MraZ protein; Region: MraZ; pfam02381 555970003888 cell division protein MraZ; Reviewed; Region: PRK00326 555970003889 MraZ protein; Region: MraZ; pfam02381 555970003890 Part of AAA domain; Region: AAA_19; pfam13245 555970003891 Family description; Region: UvrD_C_2; pfam13538 555970003892 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 555970003893 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 555970003894 ligand binding site [chemical binding]; other site 555970003895 NAD binding site [chemical binding]; other site 555970003896 tetramer interface [polypeptide binding]; other site 555970003897 catalytic site [active] 555970003898 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 555970003899 L-serine binding site [chemical binding]; other site 555970003900 ACT domain interface; other site 555970003901 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 555970003902 ATP cone domain; Region: ATP-cone; pfam03477 555970003903 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 555970003904 LexA repressor; Validated; Region: PRK00215 555970003905 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 555970003906 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 555970003907 Catalytic site [active] 555970003908 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 555970003909 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 555970003910 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 555970003911 NAD binding site [chemical binding]; other site 555970003912 dimer interface [polypeptide binding]; other site 555970003913 substrate binding site [chemical binding]; other site 555970003914 tetramer (dimer of dimers) interface [polypeptide binding]; other site 555970003915 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 555970003916 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 555970003917 HflX GTPase family; Region: HflX; cd01878 555970003918 G1 box; other site 555970003919 GTP/Mg2+ binding site [chemical binding]; other site 555970003920 Switch I region; other site 555970003921 G2 box; other site 555970003922 G3 box; other site 555970003923 Switch II region; other site 555970003924 G4 box; other site 555970003925 G5 box; other site 555970003926 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 555970003927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 555970003928 S-adenosylmethionine binding site [chemical binding]; other site 555970003929 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 555970003930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 555970003931 ATP binding site [chemical binding]; other site 555970003932 putative Mg++ binding site [ion binding]; other site 555970003933 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 555970003934 nucleotide binding region [chemical binding]; other site 555970003935 ATP-binding site [chemical binding]; other site 555970003936 Helicase associated domain (HA2); Region: HA2; pfam04408 555970003937 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 555970003938 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 555970003939 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 555970003940 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 555970003941 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 555970003942 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 555970003943 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 555970003944 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 555970003945 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 555970003946 catalytic residues [active] 555970003947 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 555970003948 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 555970003949 putative active site [active] 555970003950 oxyanion strand; other site 555970003951 catalytic triad [active] 555970003952 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 555970003953 putative active site pocket [active] 555970003954 4-fold oligomerization interface [polypeptide binding]; other site 555970003955 metal binding residues [ion binding]; metal-binding site 555970003956 3-fold/trimer interface [polypeptide binding]; other site 555970003957 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 555970003958 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970003959 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970003960 homodimer interface [polypeptide binding]; other site 555970003961 catalytic residue [active] 555970003962 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 555970003963 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 555970003964 NAD binding site [chemical binding]; other site 555970003965 dimerization interface [polypeptide binding]; other site 555970003966 product binding site; other site 555970003967 substrate binding site [chemical binding]; other site 555970003968 zinc binding site [ion binding]; other site 555970003969 catalytic residues [active] 555970003970 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 555970003971 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 555970003972 active site 555970003973 PHP Thumb interface [polypeptide binding]; other site 555970003974 metal binding site [ion binding]; metal-binding site 555970003975 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 555970003976 generic binding surface I; other site 555970003977 generic binding surface II; other site 555970003978 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 555970003979 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 555970003980 RNA binding surface [nucleotide binding]; other site 555970003981 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 555970003982 active site 555970003983 lipoprotein signal peptidase; Provisional; Region: PRK14771 555970003984 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 555970003985 YGGT family; Region: YGGT; pfam02325 555970003986 Protein of unknown function (DUF552); Region: DUF552; pfam04472 555970003987 cell division protein FtsZ; Validated; Region: PRK09330 555970003988 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 555970003989 nucleotide binding site [chemical binding]; other site 555970003990 SulA interaction site; other site 555970003991 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 555970003992 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 555970003993 FMN binding site [chemical binding]; other site 555970003994 active site 555970003995 catalytic residues [active] 555970003996 substrate binding site [chemical binding]; other site 555970003997 glycyl-tRNA synthetase; Provisional; Region: PRK04173 555970003998 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 555970003999 motif 1; other site 555970004000 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 555970004001 active site 555970004002 motif 2; other site 555970004003 motif 3; other site 555970004004 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 555970004005 anticodon binding site; other site 555970004006 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 555970004007 substrate binding site [chemical binding]; other site 555970004008 multimerization interface [polypeptide binding]; other site 555970004009 ATP binding site [chemical binding]; other site 555970004010 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 555970004011 thiamine phosphate binding site [chemical binding]; other site 555970004012 active site 555970004013 pyrophosphate binding site [ion binding]; other site 555970004014 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 555970004015 substrate binding site [chemical binding]; other site 555970004016 dimer interface [polypeptide binding]; other site 555970004017 ATP binding site [chemical binding]; other site 555970004018 Domain of unknown function DUF77; Region: DUF77; pfam01910 555970004019 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970004020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970004021 DNA binding site [nucleotide binding] 555970004022 domain linker motif; other site 555970004023 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 555970004024 putative dimerization interface [polypeptide binding]; other site 555970004025 putative ligand binding site [chemical binding]; other site 555970004026 galactoside permease; Reviewed; Region: lacY; PRK09528 555970004027 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970004028 putative substrate translocation pore; other site 555970004029 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 555970004030 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 555970004031 substrate binding [chemical binding]; other site 555970004032 active site 555970004033 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 555970004034 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 555970004035 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970004036 dimer interface [polypeptide binding]; other site 555970004037 conserved gate region; other site 555970004038 putative PBP binding loops; other site 555970004039 ABC-ATPase subunit interface; other site 555970004040 NMT1/THI5 like; Region: NMT1; pfam09084 555970004041 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 555970004042 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 555970004043 active site 555970004044 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 555970004045 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 555970004046 catalytic residue [active] 555970004047 putative FPP diphosphate binding site; other site 555970004048 putative FPP binding hydrophobic cleft; other site 555970004049 dimer interface [polypeptide binding]; other site 555970004050 putative IPP diphosphate binding site; other site 555970004051 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 555970004052 Recombination protein O N terminal; Region: RecO_N; pfam11967 555970004053 Recombination protein O C terminal; Region: RecO_C; pfam02565 555970004054 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 555970004055 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 555970004056 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 555970004057 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 555970004058 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 555970004059 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 555970004060 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 555970004061 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 555970004062 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 555970004063 DivIVA domain; Region: DivI1A_domain; TIGR03544 555970004064 DivIVA domain; Region: DivI1A_domain; TIGR03544 555970004065 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 555970004066 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 555970004067 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 555970004068 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 555970004069 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 555970004070 Part of AAA domain; Region: AAA_19; pfam13245 555970004071 Family description; Region: UvrD_C_2; pfam13538 555970004072 Phosphotransferase enzyme family; Region: APH; pfam01636 555970004073 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 555970004074 substrate binding site [chemical binding]; other site 555970004075 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 555970004076 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 555970004077 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 555970004078 active site 555970004079 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 555970004080 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 555970004081 putative active site [active] 555970004082 redox center [active] 555970004083 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 555970004084 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 555970004085 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 555970004086 glutamate racemase; Provisional; Region: PRK00865 555970004087 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 555970004088 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 555970004089 active site 555970004090 nucleophile elbow; other site 555970004091 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 555970004092 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 555970004093 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 555970004094 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 555970004095 substrate binding pocket [chemical binding]; other site 555970004096 membrane-bound complex binding site; other site 555970004097 hinge residues; other site 555970004098 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 555970004099 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970004100 Walker A/P-loop; other site 555970004101 ATP binding site [chemical binding]; other site 555970004102 Q-loop/lid; other site 555970004103 ABC transporter signature motif; other site 555970004104 Walker B; other site 555970004105 D-loop; other site 555970004106 H-loop/switch region; other site 555970004107 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 555970004108 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970004109 dimer interface [polypeptide binding]; other site 555970004110 conserved gate region; other site 555970004111 putative PBP binding loops; other site 555970004112 ABC-ATPase subunit interface; other site 555970004113 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 555970004114 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970004115 dimer interface [polypeptide binding]; other site 555970004116 conserved gate region; other site 555970004117 putative PBP binding loops; other site 555970004118 ABC-ATPase subunit interface; other site 555970004119 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 555970004120 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970004121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970004122 homodimer interface [polypeptide binding]; other site 555970004123 catalytic residue [active] 555970004124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970004125 putative PBP binding loops; other site 555970004126 ABC-ATPase subunit interface; other site 555970004127 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 555970004128 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 555970004129 Walker A/P-loop; other site 555970004130 ATP binding site [chemical binding]; other site 555970004131 Q-loop/lid; other site 555970004132 ABC transporter signature motif; other site 555970004133 Walker B; other site 555970004134 D-loop; other site 555970004135 H-loop/switch region; other site 555970004136 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 555970004137 NIL domain; Region: NIL; pfam09383 555970004138 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 555970004139 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 555970004140 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 555970004141 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 555970004142 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 555970004143 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 555970004144 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 555970004145 active site 555970004146 catalytic site [active] 555970004147 substrate binding site [chemical binding]; other site 555970004148 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 555970004149 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 555970004150 G1 box; other site 555970004151 putative GEF interaction site [polypeptide binding]; other site 555970004152 GTP/Mg2+ binding site [chemical binding]; other site 555970004153 Switch I region; other site 555970004154 G2 box; other site 555970004155 G3 box; other site 555970004156 Switch II region; other site 555970004157 G4 box; other site 555970004158 G5 box; other site 555970004159 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 555970004160 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 555970004161 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 555970004162 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 555970004163 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 555970004164 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 555970004165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970004166 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970004167 putative substrate translocation pore; other site 555970004168 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 555970004169 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 555970004170 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 555970004171 HIGH motif; other site 555970004172 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 555970004173 active site 555970004174 KMSKS motif; other site 555970004175 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 555970004176 tRNA binding surface [nucleotide binding]; other site 555970004177 anticodon binding site; other site 555970004178 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 555970004179 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 555970004180 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 555970004181 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 555970004182 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 555970004183 Walker A/P-loop; other site 555970004184 ATP binding site [chemical binding]; other site 555970004185 Q-loop/lid; other site 555970004186 ABC transporter signature motif; other site 555970004187 Walker B; other site 555970004188 D-loop; other site 555970004189 H-loop/switch region; other site 555970004190 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 555970004191 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 555970004192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970004193 Walker A/P-loop; other site 555970004194 ATP binding site [chemical binding]; other site 555970004195 Q-loop/lid; other site 555970004196 ABC transporter signature motif; other site 555970004197 Walker B; other site 555970004198 D-loop; other site 555970004199 H-loop/switch region; other site 555970004200 MarR family; Region: MarR_2; pfam12802 555970004201 Transcriptional regulators [Transcription]; Region: MarR; COG1846 555970004202 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 555970004203 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 555970004204 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 555970004205 mismatch recognition site; other site 555970004206 additional DNA contacts [nucleotide binding]; other site 555970004207 active site 555970004208 zinc binding site [ion binding]; other site 555970004209 DNA intercalation site [nucleotide binding]; other site 555970004210 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 555970004211 FIC domain binding interface [polypeptide binding]; other site 555970004212 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 555970004213 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 555970004214 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 555970004215 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 555970004216 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 555970004217 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 555970004218 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 555970004219 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 555970004220 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 555970004221 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 555970004222 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 555970004223 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 555970004224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 555970004225 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 555970004226 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 555970004227 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 555970004228 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 555970004229 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 555970004230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 555970004231 FeS/SAM binding site; other site 555970004232 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 555970004233 ATP cone domain; Region: ATP-cone; pfam03477 555970004234 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 555970004235 Class III ribonucleotide reductase; Region: RNR_III; cd01675 555970004236 active site 555970004237 Zn binding site [ion binding]; other site 555970004238 glycine loop; other site 555970004239 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 555970004240 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 555970004241 generic binding surface II; other site 555970004242 generic binding surface I; other site 555970004243 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 555970004244 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 555970004245 putative catalytic site [active] 555970004246 putative metal binding site [ion binding]; other site 555970004247 putative phosphate binding site [ion binding]; other site 555970004248 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 555970004249 aminotransferase; Validated; Region: PRK07337 555970004250 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 555970004251 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970004252 homodimer interface [polypeptide binding]; other site 555970004253 catalytic residue [active] 555970004254 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 555970004255 additional DNA contacts [nucleotide binding]; other site 555970004256 mismatch recognition site; other site 555970004257 active site 555970004258 zinc binding site [ion binding]; other site 555970004259 DNA intercalation site [nucleotide binding]; other site 555970004260 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 555970004261 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 555970004262 active site 555970004263 catalytic site [active] 555970004264 substrate binding site [chemical binding]; other site 555970004265 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 555970004266 active site 555970004267 catalytic residues [active] 555970004268 metal binding site [ion binding]; metal-binding site 555970004269 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 555970004270 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 555970004271 active site 555970004272 substrate binding site [chemical binding]; other site 555970004273 metal binding site [ion binding]; metal-binding site 555970004274 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 555970004275 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 555970004276 Zn binding site [ion binding]; other site 555970004277 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 555970004278 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 555970004279 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 555970004280 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 555970004281 dihydrodipicolinate synthase; Region: dapA; TIGR00674 555970004282 dimer interface [polypeptide binding]; other site 555970004283 active site 555970004284 catalytic residue [active] 555970004285 dihydrodipicolinate reductase; Provisional; Region: PRK00048 555970004286 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 555970004287 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 555970004288 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970004289 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970004290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 555970004291 Coenzyme A binding pocket [chemical binding]; other site 555970004292 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 555970004293 Family description; Region: UvrD_C_2; pfam13538 555970004294 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 555970004295 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 555970004296 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 555970004297 Catalytic domain of Protein Kinases; Region: PKc; cd00180 555970004298 active site 555970004299 ATP binding site [chemical binding]; other site 555970004300 substrate binding site [chemical binding]; other site 555970004301 activation loop (A-loop); other site 555970004302 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 555970004303 Interdomain contacts; other site 555970004304 Cytokine receptor motif; other site 555970004305 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 555970004306 Interdomain contacts; other site 555970004307 Cytokine receptor motif; other site 555970004308 MoxR-like ATPases [General function prediction only]; Region: COG0714 555970004309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970004310 Walker A motif; other site 555970004311 ATP binding site [chemical binding]; other site 555970004312 Walker B motif; other site 555970004313 arginine finger; other site 555970004314 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 555970004315 Protein of unknown function DUF58; Region: DUF58; pfam01882 555970004316 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 555970004317 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 555970004318 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 555970004319 phosphopeptide binding site; other site 555970004320 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 555970004321 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 555970004322 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 555970004323 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 555970004324 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 555970004325 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 555970004326 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 555970004327 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 555970004328 DNA binding site [nucleotide binding] 555970004329 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 555970004330 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 555970004331 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 555970004332 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 555970004333 RPB1 interaction site [polypeptide binding]; other site 555970004334 RPB10 interaction site [polypeptide binding]; other site 555970004335 RPB11 interaction site [polypeptide binding]; other site 555970004336 RPB3 interaction site [polypeptide binding]; other site 555970004337 RPB12 interaction site [polypeptide binding]; other site 555970004338 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 555970004339 endonuclease III; Region: ENDO3c; smart00478 555970004340 minor groove reading motif; other site 555970004341 helix-hairpin-helix signature motif; other site 555970004342 substrate binding pocket [chemical binding]; other site 555970004343 active site 555970004344 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 555970004345 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 555970004346 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 555970004347 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 555970004348 active site 555970004349 catalytic site [active] 555970004350 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 555970004351 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 555970004352 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 555970004353 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 555970004354 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 555970004355 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 555970004356 dimer interface [polypeptide binding]; other site 555970004357 active site 555970004358 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 555970004359 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 555970004360 DNA-binding site [nucleotide binding]; DNA binding site 555970004361 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 555970004362 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 555970004363 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 555970004364 Ligand binding site; other site 555970004365 Putative Catalytic site; other site 555970004366 DXD motif; other site 555970004367 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 555970004368 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 555970004369 quinone interaction residues [chemical binding]; other site 555970004370 active site 555970004371 catalytic residues [active] 555970004372 FMN binding site [chemical binding]; other site 555970004373 substrate binding site [chemical binding]; other site 555970004374 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 555970004375 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 555970004376 active site 555970004377 FMN binding site [chemical binding]; other site 555970004378 substrate binding site [chemical binding]; other site 555970004379 homotetramer interface [polypeptide binding]; other site 555970004380 catalytic residue [active] 555970004381 Transglycosylase; Region: Transgly; pfam00912 555970004382 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 555970004383 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 555970004384 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 555970004385 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 555970004386 ligand binding site [chemical binding]; other site 555970004387 flexible hinge region; other site 555970004388 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 555970004389 putative switch regulator; other site 555970004390 non-specific DNA interactions [nucleotide binding]; other site 555970004391 DNA binding site [nucleotide binding] 555970004392 sequence specific DNA binding site [nucleotide binding]; other site 555970004393 putative cAMP binding site [chemical binding]; other site 555970004394 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 555970004395 TM2 domain; Region: TM2; pfam05154 555970004396 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 555970004397 tartrate dehydrogenase; Region: TTC; TIGR02089 555970004398 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 555970004399 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 555970004400 Uncharacterized conserved protein [Function unknown]; Region: COG4850 555970004401 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 555970004402 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 555970004403 lipoyl attachment site [posttranslational modification]; other site 555970004404 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 555970004405 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 555970004406 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 555970004407 putative NADH binding site [chemical binding]; other site 555970004408 putative active site [active] 555970004409 nudix motif; other site 555970004410 putative metal binding site [ion binding]; other site 555970004411 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 555970004412 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 555970004413 nudix motif; other site 555970004414 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 555970004415 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 555970004416 catalytic residues [active] 555970004417 Domain of unknown function (DUF348); Region: DUF348; pfam03990 555970004418 G5 domain; Region: G5; pfam07501 555970004419 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 555970004420 N-acetyl-D-glucosamine binding site [chemical binding]; other site 555970004421 catalytic residue [active] 555970004422 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 555970004423 Bacterial sugar transferase; Region: Bac_transf; pfam02397 555970004424 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 555970004425 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 555970004426 Putative Catalytic site; other site 555970004427 DXD motif; other site 555970004428 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 555970004429 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 555970004430 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 555970004431 substrate binding site; other site 555970004432 tetramer interface; other site 555970004433 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 555970004434 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 555970004435 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 555970004436 NADP binding site [chemical binding]; other site 555970004437 active site 555970004438 putative substrate binding site [chemical binding]; other site 555970004439 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 555970004440 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 555970004441 NAD binding site [chemical binding]; other site 555970004442 substrate binding site [chemical binding]; other site 555970004443 homodimer interface [polypeptide binding]; other site 555970004444 active site 555970004445 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 555970004446 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 555970004447 Probable Catalytic site; other site 555970004448 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 555970004449 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 555970004450 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 555970004451 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 555970004452 active site 555970004453 putative glycosyl transferase; Provisional; Region: PRK10073 555970004454 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 555970004455 active site 555970004456 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 555970004457 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 555970004458 active site 555970004459 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 555970004460 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 555970004461 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 555970004462 active site 555970004463 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 555970004464 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 555970004465 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 555970004466 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 555970004467 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 555970004468 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 555970004469 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 555970004470 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 555970004471 active site 555970004472 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 555970004473 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 555970004474 Bacterial sugar transferase; Region: Bac_transf; pfam02397 555970004475 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970004476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970004477 putative substrate translocation pore; other site 555970004478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970004479 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 555970004480 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 555970004481 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 555970004482 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 555970004483 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 555970004484 active site 555970004485 multimer interface [polypeptide binding]; other site 555970004486 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 555970004487 predicted active site [active] 555970004488 catalytic triad [active] 555970004489 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 555970004490 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 555970004491 putative NAD(P) binding site [chemical binding]; other site 555970004492 active site 555970004493 putative substrate binding site [chemical binding]; other site 555970004494 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 555970004495 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 555970004496 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 555970004497 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 555970004498 active site 555970004499 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 555970004500 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 555970004501 Ligand binding site; other site 555970004502 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 555970004503 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 555970004504 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970004505 Walker A/P-loop; other site 555970004506 ATP binding site [chemical binding]; other site 555970004507 Q-loop/lid; other site 555970004508 ABC transporter signature motif; other site 555970004509 Walker B; other site 555970004510 D-loop; other site 555970004511 H-loop/switch region; other site 555970004512 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 555970004513 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970004514 Walker A/P-loop; other site 555970004515 ATP binding site [chemical binding]; other site 555970004516 Q-loop/lid; other site 555970004517 ABC transporter signature motif; other site 555970004518 Walker B; other site 555970004519 D-loop; other site 555970004520 H-loop/switch region; other site 555970004521 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 555970004522 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 555970004523 acyl-activating enzyme (AAE) consensus motif; other site 555970004524 putative AMP binding site [chemical binding]; other site 555970004525 putative active site [active] 555970004526 putative CoA binding site [chemical binding]; other site 555970004527 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 555970004528 putative active site [active] 555970004529 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 555970004530 dimer interface [polypeptide binding]; other site 555970004531 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 555970004532 nudix motif; other site 555970004533 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 555970004534 Low molecular weight phosphatase family; Region: LMWPc; cd00115 555970004535 active site 555970004536 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 555970004537 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 555970004538 Chain length determinant protein; Region: Wzz; cl15801 555970004539 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 555970004540 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 555970004541 Nucleotide binding site [chemical binding]; other site 555970004542 DTAP/Switch II; other site 555970004543 Switch I; other site 555970004544 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 555970004545 Transposase; Region: DDE_Tnp_ISL3; pfam01610 555970004546 homoserine kinase; Provisional; Region: PRK01212 555970004547 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 555970004548 homoserine dehydrogenase; Provisional; Region: PRK06349 555970004549 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 555970004550 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 555970004551 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 555970004552 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 555970004553 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 555970004554 catalytic residue [active] 555970004555 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 555970004556 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 555970004557 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 555970004558 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 555970004559 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 555970004560 active site 555970004561 HIGH motif; other site 555970004562 KMSK motif region; other site 555970004563 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 555970004564 tRNA binding surface [nucleotide binding]; other site 555970004565 anticodon binding site; other site 555970004566 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 555970004567 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 555970004568 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 555970004569 homotrimer interaction site [polypeptide binding]; other site 555970004570 putative active site [active] 555970004571 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 555970004572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970004573 dimer interface [polypeptide binding]; other site 555970004574 conserved gate region; other site 555970004575 putative PBP binding loops; other site 555970004576 ABC-ATPase subunit interface; other site 555970004577 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 555970004578 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 555970004579 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 555970004580 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 555970004581 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 555970004582 hypothetical protein; Provisional; Region: PRK03298 555970004583 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 555970004584 gamma subunit interface [polypeptide binding]; other site 555970004585 epsilon subunit interface [polypeptide binding]; other site 555970004586 LBP interface [polypeptide binding]; other site 555970004587 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 555970004588 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 555970004589 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 555970004590 alpha subunit interaction interface [polypeptide binding]; other site 555970004591 Walker A motif; other site 555970004592 ATP binding site [chemical binding]; other site 555970004593 Walker B motif; other site 555970004594 inhibitor binding site; inhibition site 555970004595 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 555970004596 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 555970004597 core domain interface [polypeptide binding]; other site 555970004598 delta subunit interface [polypeptide binding]; other site 555970004599 epsilon subunit interface [polypeptide binding]; other site 555970004600 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 555970004601 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 555970004602 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 555970004603 beta subunit interaction interface [polypeptide binding]; other site 555970004604 Walker A motif; other site 555970004605 ATP binding site [chemical binding]; other site 555970004606 Walker B motif; other site 555970004607 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 555970004608 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 555970004609 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 555970004610 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 555970004611 ATP synthase subunit C; Region: ATP-synt_C; cl00466 555970004612 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 555970004613 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 555970004614 homoserine O-succinyltransferase; Provisional; Region: PRK05368 555970004615 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 555970004616 proposed active site lysine [active] 555970004617 conserved cys residue [active] 555970004618 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970004619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970004620 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 555970004621 active site 555970004622 tetramer interface [polypeptide binding]; other site 555970004623 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 555970004624 Plasmid replication protein; Region: Rep_2; pfam01719 555970004625 Protein of unknown function DUF262; Region: DUF262; pfam03235 555970004626 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 555970004627 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 555970004628 active site 555970004629 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 555970004630 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 555970004631 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 555970004632 Int/Topo IB signature motif; other site 555970004633 formyl-coenzyme A transferase; Provisional; Region: PRK05398 555970004634 CoA-transferase family III; Region: CoA_transf_3; pfam02515 555970004635 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 555970004636 Cellulose or protein binding domain; Region: CBM_10; pfam02013 555970004637 Membrane transport protein; Region: Mem_trans; cl09117 555970004638 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 555970004639 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 555970004640 PYR/PP interface [polypeptide binding]; other site 555970004641 dimer interface [polypeptide binding]; other site 555970004642 TPP binding site [chemical binding]; other site 555970004643 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 555970004644 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 555970004645 TPP-binding site; other site 555970004646 dimer interface [polypeptide binding]; other site 555970004647 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 555970004648 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 555970004649 Cl- selectivity filter; other site 555970004650 Cl- binding residues [ion binding]; other site 555970004651 pore gating glutamate residue; other site 555970004652 dimer interface [polypeptide binding]; other site 555970004653 TQXA domain; Region: TQXA_dom; TIGR03934 555970004654 Cna protein B-type domain; Region: Cna_B; pfam05738 555970004655 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 555970004656 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 555970004657 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 555970004658 active site 555970004659 catalytic site [active] 555970004660 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 555970004661 dimer interface [polypeptide binding]; other site 555970004662 substrate binding site [chemical binding]; other site 555970004663 metal binding sites [ion binding]; metal-binding site 555970004664 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 555970004665 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 555970004666 DNA binding site [nucleotide binding] 555970004667 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 555970004668 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 555970004669 minor groove reading motif; other site 555970004670 helix-hairpin-helix signature motif; other site 555970004671 substrate binding pocket [chemical binding]; other site 555970004672 active site 555970004673 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 555970004674 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 555970004675 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 555970004676 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 555970004677 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 555970004678 active site 555970004679 HIGH motif; other site 555970004680 nucleotide binding site [chemical binding]; other site 555970004681 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 555970004682 active site 555970004683 KMSKS motif; other site 555970004684 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 555970004685 tRNA binding surface [nucleotide binding]; other site 555970004686 anticodon binding site; other site 555970004687 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 555970004688 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 555970004689 dimerization interface [polypeptide binding]; other site 555970004690 putative Zn2+ binding site [ion binding]; other site 555970004691 putative DNA binding site [nucleotide binding]; other site 555970004692 chorismate mutase; Provisional; Region: PRK09239 555970004693 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 555970004694 transcription termination factor Rho; Provisional; Region: PRK12608 555970004695 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 555970004696 RNA binding site [nucleotide binding]; other site 555970004697 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 555970004698 Walker A motif; other site 555970004699 ATP binding site [chemical binding]; other site 555970004700 Walker B motif; other site 555970004701 hypothetical protein; Provisional; Region: PRK07208 555970004702 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 555970004703 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 555970004704 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 555970004705 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 555970004706 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 555970004707 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 555970004708 GatB domain; Region: GatB_Yqey; pfam02637 555970004709 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 555970004710 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 555970004711 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 555970004712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970004713 ABC transporter signature motif; other site 555970004714 Walker B; other site 555970004715 D-loop; other site 555970004716 H-loop/switch region; other site 555970004717 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 555970004718 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 555970004719 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 555970004720 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 555970004721 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 555970004722 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 555970004723 Clp amino terminal domain; Region: Clp_N; pfam02861 555970004724 Clp amino terminal domain; Region: Clp_N; pfam02861 555970004725 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970004726 Walker A motif; other site 555970004727 ATP binding site [chemical binding]; other site 555970004728 Walker B motif; other site 555970004729 arginine finger; other site 555970004730 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 555970004731 Walker A motif; other site 555970004732 ATP binding site [chemical binding]; other site 555970004733 Walker B motif; other site 555970004734 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 555970004735 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 555970004736 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 555970004737 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 555970004738 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 555970004739 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 555970004740 metal ion-dependent adhesion site (MIDAS); other site 555970004741 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 555970004742 active site 555970004743 catalytic site [active] 555970004744 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 555970004745 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 555970004746 catalytic residue [active] 555970004747 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 555970004748 active site 555970004749 HIGH motif; other site 555970004750 nucleotide binding site [chemical binding]; other site 555970004751 active site 555970004752 KMSKS motif; other site 555970004753 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 555970004754 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 555970004755 amphipathic channel; other site 555970004756 Asn-Pro-Ala signature motifs; other site 555970004757 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 555970004758 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 555970004759 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 555970004760 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 555970004761 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 555970004762 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 555970004763 dimer interface [polypeptide binding]; other site 555970004764 ssDNA binding site [nucleotide binding]; other site 555970004765 tetramer (dimer of dimers) interface [polypeptide binding]; other site 555970004766 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 555970004767 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 555970004768 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 555970004769 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 555970004770 active site 555970004771 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 555970004772 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 555970004773 substrate binding site [chemical binding]; other site 555970004774 dimer interface [polypeptide binding]; other site 555970004775 ATP binding site [chemical binding]; other site 555970004776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 555970004777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 555970004778 putative substrate translocation pore; other site 555970004779 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 555970004780 active site 555970004781 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970004782 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970004783 DNA binding site [nucleotide binding] 555970004784 domain linker motif; other site 555970004785 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 555970004786 dimerization interface [polypeptide binding]; other site 555970004787 ligand binding site [chemical binding]; other site 555970004788 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 555970004789 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 555970004790 UDP-galactopyranose mutase; Region: GLF; pfam03275 555970004791 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 555970004792 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 555970004793 active site 555970004794 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 555970004795 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 555970004796 active site 555970004797 Sulfatase; Region: Sulfatase; pfam00884 555970004798 Sulfatase; Region: Sulfatase; pfam00884 555970004799 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 555970004800 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 555970004801 active site 555970004802 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 555970004803 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 555970004804 active site 555970004805 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 555970004806 active site 555970004807 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 555970004808 S-layer homology domain; Region: SLH; pfam00395 555970004809 S-layer homology domain; Region: SLH; pfam00395 555970004810 S-layer homology domain; Region: SLH; pfam00395 555970004811 MULE transposase domain; Region: MULE; pfam10551 555970004812 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 555970004813 Leucine rich repeat; Region: LRR_8; pfam13855 555970004814 S-layer homology domain; Region: SLH; pfam00395 555970004815 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 555970004816 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 555970004817 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 555970004818 Walker A/P-loop; other site 555970004819 ATP binding site [chemical binding]; other site 555970004820 Q-loop/lid; other site 555970004821 ABC transporter signature motif; other site 555970004822 Walker B; other site 555970004823 D-loop; other site 555970004824 H-loop/switch region; other site 555970004825 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 555970004826 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 555970004827 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 555970004828 active site 555970004829 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 555970004830 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 555970004831 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 555970004832 FtsX-like permease family; Region: FtsX; pfam02687 555970004833 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 555970004834 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970004835 ATP binding site [chemical binding]; other site 555970004836 Q-loop/lid; other site 555970004837 ABC transporter signature motif; other site 555970004838 Walker B; other site 555970004839 D-loop; other site 555970004840 H-loop/switch region; other site 555970004841 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 555970004842 Zn2+ binding site [ion binding]; other site 555970004843 Mg2+ binding site [ion binding]; other site 555970004844 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 555970004845 putative active site [active] 555970004846 putative dimer interface [polypeptide binding]; other site 555970004847 YL1 nuclear protein; Region: YL1; pfam05764 555970004848 K+ potassium transporter; Region: K_trans; pfam02705 555970004849 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 555970004850 active site 555970004851 Melibiase; Region: Melibiase; pfam02065 555970004852 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 555970004853 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 555970004854 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 555970004855 Walker A/P-loop; other site 555970004856 ATP binding site [chemical binding]; other site 555970004857 Q-loop/lid; other site 555970004858 ABC transporter signature motif; other site 555970004859 Walker B; other site 555970004860 D-loop; other site 555970004861 H-loop/switch region; other site 555970004862 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 555970004863 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 555970004864 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 555970004865 Walker A/P-loop; other site 555970004866 ATP binding site [chemical binding]; other site 555970004867 Q-loop/lid; other site 555970004868 ABC transporter signature motif; other site 555970004869 Walker B; other site 555970004870 D-loop; other site 555970004871 H-loop/switch region; other site 555970004872 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 555970004873 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 555970004874 active site 555970004875 HIGH motif; other site 555970004876 KMSKS motif; other site 555970004877 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 555970004878 tRNA binding surface [nucleotide binding]; other site 555970004879 anticodon binding site; other site 555970004880 Predicted methyltransferases [General function prediction only]; Region: COG0313 555970004881 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 555970004882 putative SAM binding site [chemical binding]; other site 555970004883 putative homodimer interface [polypeptide binding]; other site 555970004884 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 555970004885 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 555970004886 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 555970004887 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 555970004888 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 555970004889 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 555970004890 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 555970004891 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 555970004892 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 555970004893 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 555970004894 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 555970004895 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 555970004896 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 555970004897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970004898 motif II; other site 555970004899 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 555970004900 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 555970004901 DNA binding residues [nucleotide binding] 555970004902 putative dimer interface [polypeptide binding]; other site 555970004903 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 555970004904 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 555970004905 HSP70 interaction site [polypeptide binding]; other site 555970004906 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 555970004907 substrate binding site [polypeptide binding]; other site 555970004908 dimer interface [polypeptide binding]; other site 555970004909 GrpE; Region: GrpE; pfam01025 555970004910 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 555970004911 dimer interface [polypeptide binding]; other site 555970004912 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 555970004913 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 555970004914 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 555970004915 nucleotide binding site [chemical binding]; other site 555970004916 NEF interaction site [polypeptide binding]; other site 555970004917 SBD interface [polypeptide binding]; other site 555970004918 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970004919 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970004920 DNA binding site [nucleotide binding] 555970004921 domain linker motif; other site 555970004922 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 555970004923 ligand binding site [chemical binding]; other site 555970004924 dimerization interface [polypeptide binding]; other site 555970004925 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 555970004926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970004927 motif II; other site 555970004928 pullulanase, type I; Region: pulA_typeI; TIGR02104 555970004929 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 555970004930 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 555970004931 Ca binding site [ion binding]; other site 555970004932 active site 555970004933 catalytic site [active] 555970004934 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 555970004935 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970004936 dimer interface [polypeptide binding]; other site 555970004937 conserved gate region; other site 555970004938 putative PBP binding loops; other site 555970004939 ABC-ATPase subunit interface; other site 555970004940 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 555970004941 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970004942 dimer interface [polypeptide binding]; other site 555970004943 conserved gate region; other site 555970004944 putative PBP binding loops; other site 555970004945 ABC-ATPase subunit interface; other site 555970004946 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 555970004947 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 555970004948 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 555970004949 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 555970004950 active site 555970004951 catalytic site [active] 555970004952 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 555970004953 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 555970004954 Protein of unknown function, DUF624; Region: DUF624; pfam04854 555970004955 Protein of unknown function, DUF624; Region: DUF624; cl02369 555970004956 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 555970004957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970004958 dimer interface [polypeptide binding]; other site 555970004959 conserved gate region; other site 555970004960 putative PBP binding loops; other site 555970004961 ABC-ATPase subunit interface; other site 555970004962 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 555970004963 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970004964 dimer interface [polypeptide binding]; other site 555970004965 conserved gate region; other site 555970004966 putative PBP binding loops; other site 555970004967 ABC-ATPase subunit interface; other site 555970004968 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970004969 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970004970 DNA binding site [nucleotide binding] 555970004971 domain linker motif; other site 555970004972 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 555970004973 ligand binding site [chemical binding]; other site 555970004974 dimerization interface [polypeptide binding]; other site 555970004975 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 555970004976 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 555970004977 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 555970004978 active site 555970004979 catalytic site [active] 555970004980 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 555970004981 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970004982 catalytic core [active] 555970004983 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 555970004984 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 555970004985 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 555970004986 dimer interface [polypeptide binding]; other site 555970004987 FMN binding site [chemical binding]; other site 555970004988 NADPH bind site [chemical binding]; other site 555970004989 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 555970004990 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 555970004991 active site 555970004992 catalytic triad [active] 555970004993 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 555970004994 RelB antitoxin; Region: RelB; cl01171 555970004995 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 555970004996 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 555970004997 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 555970004998 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 555970004999 Transcriptional regulators [Transcription]; Region: PurR; COG1609 555970005000 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 555970005001 DNA binding site [nucleotide binding] 555970005002 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 555970005003 dimerization interface [polypeptide binding]; other site 555970005004 ligand binding site [chemical binding]; other site 555970005005 NAD-dependent deacetylase; Provisional; Region: PRK00481 555970005006 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 555970005007 threonine dehydratase; Provisional; Region: PRK08198 555970005008 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 555970005009 tetramer interface [polypeptide binding]; other site 555970005010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 555970005011 catalytic residue [active] 555970005012 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 555970005013 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 555970005014 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 555970005015 Ca binding site [ion binding]; other site 555970005016 active site 555970005017 catalytic site [active] 555970005018 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 555970005019 Probable galactinol--sucrose galactosyltransferase; Region: PLN02684 555970005020 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 555970005021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970005022 dimer interface [polypeptide binding]; other site 555970005023 conserved gate region; other site 555970005024 putative PBP binding loops; other site 555970005025 ABC-ATPase subunit interface; other site 555970005026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 555970005027 dimer interface [polypeptide binding]; other site 555970005028 conserved gate region; other site 555970005029 putative PBP binding loops; other site 555970005030 ABC-ATPase subunit interface; other site 555970005031 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 555970005032 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 555970005033 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 555970005034 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 555970005035 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 555970005036 Melibiase; Region: Melibiase; pfam02065 555970005037 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 555970005038 nucleoside/Zn binding site; other site 555970005039 dimer interface [polypeptide binding]; other site 555970005040 catalytic motif [active] 555970005041 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 555970005042 Predicted esterase [General function prediction only]; Region: COG0400 555970005043 Serine hydrolase (FSH1); Region: FSH1; pfam03959 555970005044 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 555970005045 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 555970005046 trimer interface [polypeptide binding]; other site 555970005047 active site 555970005048 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 555970005049 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 555970005050 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 555970005051 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 555970005052 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 555970005053 motif II; other site 555970005054 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 555970005055 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 555970005056 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 555970005057 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 555970005058 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 555970005059 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 555970005060 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 555970005061 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 555970005062 Walker A/P-loop; other site 555970005063 ATP binding site [chemical binding]; other site 555970005064 Q-loop/lid; other site 555970005065 ABC transporter signature motif; other site 555970005066 Walker B; other site 555970005067 D-loop; other site 555970005068 H-loop/switch region; other site 555970005069 TOBE domain; Region: TOBE_2; pfam08402 555970005070 Ion channel; Region: Ion_trans_2; pfam07885 555970005071 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 555970005072 Catalytic domain of Protein Kinases; Region: PKc; cd00180 555970005073 active site 555970005074 ATP binding site [chemical binding]; other site 555970005075 substrate binding site [chemical binding]; other site 555970005076 activation loop (A-loop); other site 555970005077 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 555970005078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 555970005079 Domain of unknown function (DUF348); Region: DUF348; pfam03990 555970005080 G5 domain; Region: G5; pfam07501 555970005081 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 555970005082 N-acetyl-D-glucosamine binding site [chemical binding]; other site 555970005083 catalytic residue [active] 555970005084 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 555970005085 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 555970005086 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 555970005087 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 555970005088 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 555970005089 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 555970005090 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 555970005091 active site 555970005092 NTP binding site [chemical binding]; other site 555970005093 metal binding triad [ion binding]; metal-binding site 555970005094 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 555970005095 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 555970005096 Zn2+ binding site [ion binding]; other site 555970005097 Mg2+ binding site [ion binding]; other site 555970005098 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 555970005099 active site 555970005100 Ap6A binding site [chemical binding]; other site 555970005101 nudix motif; other site 555970005102 metal binding site [ion binding]; metal-binding site 555970005103 integral membrane protein MviN; Region: mviN; TIGR01695 555970005104 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 555970005105 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 555970005106 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 555970005107 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 555970005108 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 555970005109 ParB-like nuclease domain; Region: ParB; smart00470 555970005110 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 555970005111 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 555970005112 P-loop; other site 555970005113 Magnesium ion binding site [ion binding]; other site 555970005114 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 555970005115 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 555970005116 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 555970005117 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 555970005118 G-X-X-G motif; other site 555970005119 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 555970005120 RxxxH motif; other site 555970005121 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 555970005122 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 555970005123 IncFII RepA protein family; Region: IncFII_repA; cl11495 555970005124 hypothetical protein; Provisional; Region: PRK14372 555970005125 Ribonuclease P; Region: Ribonuclease_P; pfam00825 555970005126 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399