-- dump date 20140619_002211 -- class Genbank::misc_feature -- table misc_feature_note -- id note 573236000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 573236000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236000003 Walker A motif; other site 573236000004 ATP binding site [chemical binding]; other site 573236000005 Walker B motif; other site 573236000006 arginine finger; other site 573236000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 573236000008 DnaA box-binding interface [nucleotide binding]; other site 573236000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 573236000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 573236000011 putative DNA binding surface [nucleotide binding]; other site 573236000012 dimer interface [polypeptide binding]; other site 573236000013 beta-clamp/clamp loader binding surface; other site 573236000014 beta-clamp/translesion DNA polymerase binding surface; other site 573236000015 recombination protein F; Reviewed; Region: recF; PRK00064 573236000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000017 Walker A/P-loop; other site 573236000018 ATP binding site [chemical binding]; other site 573236000019 Q-loop/lid; other site 573236000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000021 ABC transporter signature motif; other site 573236000022 Walker B; other site 573236000023 D-loop; other site 573236000024 H-loop/switch region; other site 573236000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 573236000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 573236000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573236000028 Mg2+ binding site [ion binding]; other site 573236000029 G-X-G motif; other site 573236000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573236000031 anchoring element; other site 573236000032 dimer interface [polypeptide binding]; other site 573236000033 ATP binding site [chemical binding]; other site 573236000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 573236000035 active site 573236000036 putative metal-binding site [ion binding]; other site 573236000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573236000038 DNA gyrase subunit A; Validated; Region: PRK05560 573236000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573236000040 CAP-like domain; other site 573236000041 active site 573236000042 primary dimer interface [polypeptide binding]; other site 573236000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573236000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573236000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573236000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573236000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573236000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 573236000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 573236000050 VanZ like family; Region: VanZ; cl01971 573236000051 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 573236000052 Haemolysin-III related; Region: HlyIII; pfam03006 573236000053 glutamate dehydrogenase; Provisional; Region: PRK09414 573236000054 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 573236000055 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 573236000056 NAD(P) binding site [chemical binding]; other site 573236000057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236000058 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236000059 putative substrate translocation pore; other site 573236000060 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 573236000061 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 573236000062 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 573236000063 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 573236000064 Protein of unknown function DUF45; Region: DUF45; pfam01863 573236000065 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 573236000066 MarR family; Region: MarR_2; pfam12802 573236000067 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 573236000068 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573236000069 non-specific DNA interactions [nucleotide binding]; other site 573236000070 DNA binding site [nucleotide binding] 573236000071 sequence specific DNA binding site [nucleotide binding]; other site 573236000072 putative cAMP binding site [chemical binding]; other site 573236000073 6-phosphogluconolactonase; Provisional; Region: PRK11028 573236000074 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000075 Walker A/P-loop; other site 573236000076 ATP binding site [chemical binding]; other site 573236000077 Q-loop/lid; other site 573236000078 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 573236000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000080 ABC transporter signature motif; other site 573236000081 Walker B; other site 573236000082 D-loop; other site 573236000083 H-loop/switch region; other site 573236000084 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000085 Walker A/P-loop; other site 573236000086 ATP binding site [chemical binding]; other site 573236000087 Q-loop/lid; other site 573236000088 ABC transporter signature motif; other site 573236000089 Walker B; other site 573236000090 D-loop; other site 573236000091 H-loop/switch region; other site 573236000092 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573236000093 S-adenosylmethionine binding site [chemical binding]; other site 573236000094 Predicted flavoprotein [General function prediction only]; Region: COG0431 573236000095 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573236000096 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 573236000097 homodimer interface [polypeptide binding]; other site 573236000098 chemical substrate binding site [chemical binding]; other site 573236000099 oligomer interface [polypeptide binding]; other site 573236000100 metal binding site [ion binding]; metal-binding site 573236000101 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 573236000102 GIY-YIG motif/motif A; other site 573236000103 active site 573236000104 catalytic site [active] 573236000105 Helix-turn-helix domain; Region: HTH_17; pfam12728 573236000106 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 573236000107 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 573236000108 cofactor binding site; other site 573236000109 DNA binding site [nucleotide binding] 573236000110 substrate interaction site [chemical binding]; other site 573236000111 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 573236000112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 573236000113 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 573236000114 PemK-like protein; Region: PemK; pfam02452 573236000115 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573236000116 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573236000117 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 573236000118 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 573236000119 catalytic tetrad [active] 573236000120 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573236000121 active site 573236000122 catalytic tetrad [active] 573236000123 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573236000124 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573236000125 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573236000126 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 573236000127 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573236000128 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 573236000129 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 573236000130 Transposase; Region: DDE_Tnp_ISL3; pfam01610 573236000131 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 573236000132 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 573236000133 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 573236000134 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 573236000135 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 573236000136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236000137 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236000138 putative substrate translocation pore; other site 573236000139 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573236000140 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573236000141 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 573236000142 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 573236000143 dimerization interface [polypeptide binding]; other site 573236000144 DPS ferroxidase diiron center [ion binding]; other site 573236000145 ion pore; other site 573236000146 Domain of unknown function DUF21; Region: DUF21; pfam01595 573236000147 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573236000148 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573236000149 Transporter associated domain; Region: CorC_HlyC; smart01091 573236000150 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 573236000151 active site clefts [active] 573236000152 zinc binding site [ion binding]; other site 573236000153 dimer interface [polypeptide binding]; other site 573236000154 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236000155 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236000156 DNA binding site [nucleotide binding] 573236000157 domain linker motif; other site 573236000158 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 573236000159 ligand binding site [chemical binding]; other site 573236000160 dimerization interface (open form) [polypeptide binding]; other site 573236000161 dimerization interface (closed form) [polypeptide binding]; other site 573236000162 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 573236000163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000164 ABC transporter; Region: ABC_tran; pfam00005 573236000165 Q-loop/lid; other site 573236000166 ABC transporter signature motif; other site 573236000167 Walker B; other site 573236000168 D-loop; other site 573236000169 H-loop/switch region; other site 573236000170 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236000171 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236000172 DNA binding site [nucleotide binding] 573236000173 domain linker motif; other site 573236000174 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573236000175 ligand binding site [chemical binding]; other site 573236000176 dimerization interface [polypeptide binding]; other site 573236000177 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 573236000178 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 573236000179 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 573236000180 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 573236000181 putative N- and C-terminal domain interface [polypeptide binding]; other site 573236000182 putative active site [active] 573236000183 MgATP binding site [chemical binding]; other site 573236000184 catalytic site [active] 573236000185 metal binding site [ion binding]; metal-binding site 573236000186 putative carbohydrate binding site [chemical binding]; other site 573236000187 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 573236000188 intersubunit interface [polypeptide binding]; other site 573236000189 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 573236000190 active site 573236000191 Zn2+ binding site [ion binding]; other site 573236000192 L-arabinose isomerase; Provisional; Region: PRK02929 573236000193 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 573236000194 hexamer (dimer of trimers) interface [polypeptide binding]; other site 573236000195 trimer interface [polypeptide binding]; other site 573236000196 substrate binding site [chemical binding]; other site 573236000197 Mn binding site [ion binding]; other site 573236000198 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573236000199 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573236000200 active site 573236000201 catalytic tetrad [active] 573236000202 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 573236000203 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 573236000204 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 573236000205 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 573236000206 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 573236000207 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 573236000208 Transposase; Region: DDE_Tnp_ISL3; pfam01610 573236000209 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 573236000210 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 573236000211 active site 573236000212 HIGH motif; other site 573236000213 dimer interface [polypeptide binding]; other site 573236000214 KMSKS motif; other site 573236000215 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 573236000216 homodimer interface [polypeptide binding]; other site 573236000217 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 573236000218 active site pocket [active] 573236000219 Rhomboid family; Region: Rhomboid; pfam01694 573236000220 Methyltransferase domain; Region: Methyltransf_26; pfam13659 573236000221 putative septation inhibitor protein; Reviewed; Region: PRK02251 573236000222 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 573236000223 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 573236000224 active site 573236000225 catalytic site [active] 573236000226 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 573236000227 Glutamine amidotransferase class-I; Region: GATase; pfam00117 573236000228 glutamine binding [chemical binding]; other site 573236000229 catalytic triad [active] 573236000230 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 573236000231 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573236000232 active site 573236000233 ATP binding site [chemical binding]; other site 573236000234 substrate binding site [chemical binding]; other site 573236000235 activation loop (A-loop); other site 573236000236 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573236000237 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573236000238 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573236000239 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573236000240 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573236000241 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573236000242 active site 573236000243 ATP binding site [chemical binding]; other site 573236000244 substrate binding site [chemical binding]; other site 573236000245 activation loop (A-loop); other site 573236000246 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 573236000247 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573236000248 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573236000249 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 573236000250 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 573236000251 active site 573236000252 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 573236000253 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 573236000254 phosphopeptide binding site; other site 573236000255 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 573236000256 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 573236000257 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 573236000258 phosphopeptide binding site; other site 573236000259 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 573236000260 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573236000261 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 573236000262 EamA-like transporter family; Region: EamA; pfam00892 573236000263 EamA-like transporter family; Region: EamA; pfam00892 573236000264 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573236000265 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 573236000266 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 573236000267 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573236000268 S-adenosylmethionine binding site [chemical binding]; other site 573236000269 Predicted membrane protein [Function unknown]; Region: COG2261 573236000270 ferredoxin-NADP+ reductase; Region: PLN02852 573236000271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573236000272 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 573236000273 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573236000274 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573236000275 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 573236000276 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 573236000277 protein binding site [polypeptide binding]; other site 573236000278 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573236000279 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 573236000280 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 573236000281 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 573236000282 heat shock protein HtpX; Provisional; Region: PRK03072 573236000283 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 573236000284 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 573236000285 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236000286 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236000287 putative substrate translocation pore; other site 573236000288 RelB antitoxin; Region: RelB; cl01171 573236000289 methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901 573236000290 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 573236000291 DNA binding site [nucleotide binding] 573236000292 active site 573236000293 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 573236000294 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573236000295 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 573236000296 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 573236000297 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573236000298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573236000299 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573236000300 dimerization interface [polypeptide binding]; other site 573236000301 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573236000302 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573236000303 active site 573236000304 catalytic tetrad [active] 573236000305 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 573236000306 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 573236000307 FAD binding pocket [chemical binding]; other site 573236000308 conserved FAD binding motif [chemical binding]; other site 573236000309 phosphate binding motif [ion binding]; other site 573236000310 beta-alpha-beta structure motif; other site 573236000311 NAD binding pocket [chemical binding]; other site 573236000312 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573236000313 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 573236000314 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 573236000315 DNA binding residues [nucleotide binding] 573236000316 putative dimer interface [polypeptide binding]; other site 573236000317 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573236000318 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 573236000319 NADH(P)-binding; Region: NAD_binding_10; pfam13460 573236000320 NAD(P) binding site [chemical binding]; other site 573236000321 putative active site [active] 573236000322 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 573236000323 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 573236000324 catalytic Zn binding site [ion binding]; other site 573236000325 NAD(P) binding site [chemical binding]; other site 573236000326 structural Zn binding site [ion binding]; other site 573236000327 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573236000328 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573236000329 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573236000330 dimerization interface [polypeptide binding]; other site 573236000331 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573236000332 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 573236000333 NodB motif; other site 573236000334 active site 573236000335 catalytic site [active] 573236000336 metal binding site [ion binding]; metal-binding site 573236000337 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 573236000338 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 573236000339 active site 573236000340 intersubunit interface [polypeptide binding]; other site 573236000341 zinc binding site [ion binding]; other site 573236000342 Na+ binding site [ion binding]; other site 573236000343 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 573236000344 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 573236000345 GDP-binding site [chemical binding]; other site 573236000346 ACT binding site; other site 573236000347 IMP binding site; other site 573236000348 CrcB-like protein; Region: CRCB; pfam02537 573236000349 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 573236000350 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 573236000351 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 573236000352 TM-ABC transporter signature motif; other site 573236000353 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 573236000354 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 573236000355 TM-ABC transporter signature motif; other site 573236000356 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 573236000357 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 573236000358 Walker A/P-loop; other site 573236000359 ATP binding site [chemical binding]; other site 573236000360 Q-loop/lid; other site 573236000361 ABC transporter signature motif; other site 573236000362 Walker B; other site 573236000363 D-loop; other site 573236000364 H-loop/switch region; other site 573236000365 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 573236000366 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 573236000367 Walker A/P-loop; other site 573236000368 ATP binding site [chemical binding]; other site 573236000369 Q-loop/lid; other site 573236000370 ABC transporter signature motif; other site 573236000371 Walker B; other site 573236000372 D-loop; other site 573236000373 H-loop/switch region; other site 573236000374 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 573236000375 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 573236000376 ligand binding site [chemical binding]; other site 573236000377 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236000378 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236000379 DNA binding site [nucleotide binding] 573236000380 domain linker motif; other site 573236000381 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573236000382 sucrose phosphorylase; Provisional; Region: PRK13840 573236000383 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 573236000384 active site 573236000385 homodimer interface [polypeptide binding]; other site 573236000386 catalytic site [active] 573236000387 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 573236000388 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236000389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236000390 putative substrate translocation pore; other site 573236000391 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 573236000392 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 573236000393 ligand binding site [chemical binding]; other site 573236000394 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 573236000395 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573236000396 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573236000397 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 573236000398 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 573236000399 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 573236000400 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573236000401 Protein of unknown function (DUF1778); Region: DUF1778; cl01845 573236000402 metabolite-proton symporter; Region: 2A0106; TIGR00883 573236000403 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236000404 putative substrate translocation pore; other site 573236000405 ketol-acid reductoisomerase; Provisional; Region: PRK05479 573236000406 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 573236000407 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 573236000408 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573236000409 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 573236000410 active site 573236000411 catalytic triad [active] 573236000412 oxyanion hole [active] 573236000413 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 573236000414 beta-galactosidase; Region: BGL; TIGR03356 573236000415 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236000416 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236000417 DNA binding site [nucleotide binding] 573236000418 domain linker motif; other site 573236000419 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573236000420 ligand binding site [chemical binding]; other site 573236000421 dimerization interface [polypeptide binding]; other site 573236000422 Protein of unknown function, DUF624; Region: DUF624; pfam04854 573236000423 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 573236000424 putative active cleft [active] 573236000425 dimerization interface [polypeptide binding]; other site 573236000426 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 573236000427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000428 Walker A/P-loop; other site 573236000429 ATP binding site [chemical binding]; other site 573236000430 Q-loop/lid; other site 573236000431 ABC transporter signature motif; other site 573236000432 Walker B; other site 573236000433 D-loop; other site 573236000434 H-loop/switch region; other site 573236000435 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 573236000436 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 573236000437 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573236000438 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573236000439 Walker A/P-loop; other site 573236000440 ATP binding site [chemical binding]; other site 573236000441 Q-loop/lid; other site 573236000442 ABC transporter signature motif; other site 573236000443 Walker B; other site 573236000444 D-loop; other site 573236000445 H-loop/switch region; other site 573236000446 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573236000447 FtsX-like permease family; Region: FtsX; pfam02687 573236000448 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573236000449 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 573236000450 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573236000451 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573236000452 FtsX-like permease family; Region: FtsX; pfam02687 573236000453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000454 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573236000455 ABC transporter signature motif; other site 573236000456 Walker B; other site 573236000457 D-loop; other site 573236000458 H-loop/switch region; other site 573236000459 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 573236000460 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573236000461 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573236000462 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000463 Walker A/P-loop; other site 573236000464 ATP binding site [chemical binding]; other site 573236000465 Q-loop/lid; other site 573236000466 ABC transporter signature motif; other site 573236000467 Walker B; other site 573236000468 D-loop; other site 573236000469 H-loop/switch region; other site 573236000470 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573236000471 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573236000472 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573236000473 Walker A/P-loop; other site 573236000474 ATP binding site [chemical binding]; other site 573236000475 Q-loop/lid; other site 573236000476 ABC transporter signature motif; other site 573236000477 Walker B; other site 573236000478 D-loop; other site 573236000479 H-loop/switch region; other site 573236000480 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 573236000481 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 573236000482 NodB motif; other site 573236000483 active site 573236000484 catalytic site [active] 573236000485 metal binding site [ion binding]; metal-binding site 573236000486 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 573236000487 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 573236000488 active site 573236000489 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 573236000490 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 573236000491 active site 573236000492 substrate binding site [chemical binding]; other site 573236000493 trimer interface [polypeptide binding]; other site 573236000494 CoA binding site [chemical binding]; other site 573236000495 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 573236000496 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 573236000497 ligand binding site [chemical binding]; other site 573236000498 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573236000499 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573236000500 Predicted membrane protein [Function unknown]; Region: COG1511 573236000501 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 573236000502 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 573236000503 Predicted membrane protein [Function unknown]; Region: COG1511 573236000504 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 573236000505 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 573236000506 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 573236000507 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573236000508 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573236000509 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573236000510 Walker A/P-loop; other site 573236000511 ATP binding site [chemical binding]; other site 573236000512 Q-loop/lid; other site 573236000513 ABC transporter signature motif; other site 573236000514 Walker B; other site 573236000515 D-loop; other site 573236000516 H-loop/switch region; other site 573236000517 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236000518 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 573236000519 Walker A/P-loop; other site 573236000520 ATP binding site [chemical binding]; other site 573236000521 Q-loop/lid; other site 573236000522 ABC transporter signature motif; other site 573236000523 Walker B; other site 573236000524 D-loop; other site 573236000525 H-loop/switch region; other site 573236000526 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573236000527 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 573236000528 intersubunit interface [polypeptide binding]; other site 573236000529 YodA lipocalin-like domain; Region: YodA; cl01365 573236000530 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 573236000531 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 573236000532 active site 573236000533 nucleophile elbow; other site 573236000534 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573236000535 Peptidase family C69; Region: Peptidase_C69; pfam03577 573236000536 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573236000537 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573236000538 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 573236000539 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 573236000540 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573236000541 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 573236000542 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 573236000543 Nitrogen regulatory protein P-II; Region: P-II; smart00938 573236000544 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573236000545 metal binding triad; other site 573236000546 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 573236000547 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 573236000548 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573236000549 sequence-specific DNA binding site [nucleotide binding]; other site 573236000550 salt bridge; other site 573236000551 replicative DNA helicase; Region: DnaB; TIGR00665 573236000552 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 573236000553 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 573236000554 Walker A motif; other site 573236000555 ATP binding site [chemical binding]; other site 573236000556 Walker B motif; other site 573236000557 DNA binding loops [nucleotide binding] 573236000558 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573236000559 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 573236000560 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 573236000561 catalytic triad [active] 573236000562 Uncharacterized conserved protein [Function unknown]; Region: COG3937 573236000563 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 573236000564 ABC1 family; Region: ABC1; cl17513 573236000565 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 573236000566 active site 573236000567 catalytic site [active] 573236000568 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 573236000569 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573236000570 active site 573236000571 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 573236000572 active site 573236000573 Ap6A binding site [chemical binding]; other site 573236000574 nudix motif; other site 573236000575 metal binding site [ion binding]; metal-binding site 573236000576 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236000577 catalytic core [active] 573236000578 polyphosphate kinase; Provisional; Region: PRK05443 573236000579 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 573236000580 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 573236000581 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 573236000582 putative domain interface [polypeptide binding]; other site 573236000583 putative active site [active] 573236000584 catalytic site [active] 573236000585 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 573236000586 putative domain interface [polypeptide binding]; other site 573236000587 putative active site [active] 573236000588 catalytic site [active] 573236000589 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 573236000590 Type II/IV secretion system protein; Region: T2SE; pfam00437 573236000591 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573236000592 Walker B motif; other site 573236000593 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 573236000594 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 573236000595 TadE-like protein; Region: TadE; pfam07811 573236000596 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 573236000597 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236000598 Walker A motif; other site 573236000599 ATP binding site [chemical binding]; other site 573236000600 Walker B motif; other site 573236000601 arginine finger; other site 573236000602 recombination protein RecR; Reviewed; Region: recR; PRK00076 573236000603 RecR protein; Region: RecR; pfam02132 573236000604 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 573236000605 putative active site [active] 573236000606 putative metal-binding site [ion binding]; other site 573236000607 tetramer interface [polypeptide binding]; other site 573236000608 aspartate kinase; Reviewed; Region: PRK06635 573236000609 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 573236000610 putative nucleotide binding site [chemical binding]; other site 573236000611 putative catalytic residues [active] 573236000612 putative Mg ion binding site [ion binding]; other site 573236000613 putative aspartate binding site [chemical binding]; other site 573236000614 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 573236000615 putative allosteric regulatory site; other site 573236000616 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 573236000617 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 573236000618 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573236000619 2-isopropylmalate synthase; Validated; Region: PRK03739 573236000620 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 573236000621 active site 573236000622 catalytic residues [active] 573236000623 metal binding site [ion binding]; metal-binding site 573236000624 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 573236000625 Transglycosylase; Region: Transgly; pfam00912 573236000626 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 573236000627 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573236000628 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 573236000629 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 573236000630 PAP2 superfamily; Region: PAP2; pfam01569 573236000631 active site 573236000632 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 573236000633 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 573236000634 active site 573236000635 interdomain interaction site; other site 573236000636 putative metal-binding site [ion binding]; other site 573236000637 nucleotide binding site [chemical binding]; other site 573236000638 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 573236000639 domain I; other site 573236000640 phosphate binding site [ion binding]; other site 573236000641 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 573236000642 domain II; other site 573236000643 domain III; other site 573236000644 nucleotide binding site [chemical binding]; other site 573236000645 DNA binding groove [nucleotide binding] 573236000646 catalytic site [active] 573236000647 domain IV; other site 573236000648 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 573236000649 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 573236000650 thymidylate kinase; Validated; Region: tmk; PRK00698 573236000651 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 573236000652 TMP-binding site; other site 573236000653 ATP-binding site [chemical binding]; other site 573236000654 DNA polymerase III subunit delta'; Validated; Region: PRK07940 573236000655 DNA polymerase III subunit delta'; Validated; Region: PRK08485 573236000656 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 573236000657 substrate binding site [chemical binding]; other site 573236000658 Peptidase family C69; Region: Peptidase_C69; pfam03577 573236000659 Peptidase family C69; Region: Peptidase_C69; pfam03577 573236000660 AAA domain; Region: AAA_14; pfam13173 573236000661 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 573236000662 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573236000663 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 573236000664 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 573236000665 putative active site [active] 573236000666 Predicted membrane protein [Function unknown]; Region: COG2246 573236000667 GtrA-like protein; Region: GtrA; pfam04138 573236000668 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236000669 catalytic core [active] 573236000670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236000671 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236000672 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 573236000673 Transposase; Region: DDE_Tnp_ISL3; pfam01610 573236000674 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 573236000675 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573236000676 active site 573236000677 HIGH motif; other site 573236000678 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 573236000679 active site 573236000680 KMSKS motif; other site 573236000681 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 573236000682 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 573236000683 putative active site [active] 573236000684 putative metal binding site [ion binding]; other site 573236000685 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 573236000686 Transcriptional regulator [Transcription]; Region: IclR; COG1414 573236000687 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 573236000688 Bacterial transcriptional regulator; Region: IclR; pfam01614 573236000689 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 573236000690 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 573236000691 substrate binding site [chemical binding]; other site 573236000692 ligand binding site [chemical binding]; other site 573236000693 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 573236000694 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 573236000695 substrate binding site [chemical binding]; other site 573236000696 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573236000697 AsnC family; Region: AsnC_trans_reg; pfam01037 573236000698 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 573236000699 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573236000700 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573236000701 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 573236000702 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 573236000703 hinge; other site 573236000704 active site 573236000705 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573236000706 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573236000707 putative acyl-acceptor binding pocket; other site 573236000708 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 573236000709 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573236000710 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 573236000711 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 573236000712 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 573236000713 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573236000714 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 573236000715 CAAX protease self-immunity; Region: Abi; pfam02517 573236000716 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 573236000717 Mechanosensitive ion channel; Region: MS_channel; pfam00924 573236000718 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573236000719 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573236000720 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 573236000721 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 573236000722 nucleophilic elbow; other site 573236000723 catalytic triad; other site 573236000724 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 573236000725 Predicted membrane protein [Function unknown]; Region: COG4905 573236000726 aspartate aminotransferase; Provisional; Region: PRK06836 573236000727 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236000728 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236000729 homodimer interface [polypeptide binding]; other site 573236000730 catalytic residue [active] 573236000731 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 573236000732 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573236000733 binding surface 573236000734 TPR motif; other site 573236000735 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573236000736 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 573236000737 substrate binding site [chemical binding]; other site 573236000738 ATP binding site [chemical binding]; other site 573236000739 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 573236000740 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 573236000741 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 573236000742 ssDNA binding site; other site 573236000743 generic binding surface II; other site 573236000744 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573236000745 ATP binding site [chemical binding]; other site 573236000746 putative Mg++ binding site [ion binding]; other site 573236000747 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236000748 nucleotide binding region [chemical binding]; other site 573236000749 ATP-binding site [chemical binding]; other site 573236000750 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 573236000751 metal ion-dependent adhesion site (MIDAS); other site 573236000752 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 573236000753 T surface-antigen of pili; Region: FctA; pfam12892 573236000754 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 573236000755 T surface-antigen of pili; Region: FctA; pfam12892 573236000756 T surface-antigen of pili; Region: FctA; pfam12892 573236000757 T surface-antigen of pili; Region: FctA; pfam12892 573236000758 T surface-antigen of pili; Region: FctA; pfam12892 573236000759 T surface-antigen of pili; Region: FctA; pfam12892 573236000760 T surface-antigen of pili; Region: FctA; pfam12892 573236000761 T surface-antigen of pili; Region: FctA; pfam12892 573236000762 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 573236000763 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 573236000764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573236000765 S-adenosylmethionine binding site [chemical binding]; other site 573236000766 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 573236000767 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 573236000768 RimM N-terminal domain; Region: RimM; pfam01782 573236000769 PRC-barrel domain; Region: PRC; pfam05239 573236000770 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 573236000771 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 573236000772 G-X-X-G motif; other site 573236000773 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 573236000774 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 573236000775 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573236000776 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573236000777 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573236000778 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 573236000779 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573236000780 putative catalytic site [active] 573236000781 putative metal binding site [ion binding]; other site 573236000782 putative phosphate binding site [ion binding]; other site 573236000783 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573236000784 putative catalytic site [active] 573236000785 putative phosphate binding site [ion binding]; other site 573236000786 putative metal binding site [ion binding]; other site 573236000787 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 573236000788 Cation efflux family; Region: Cation_efflux; pfam01545 573236000789 signal recognition particle protein; Provisional; Region: PRK10867 573236000790 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 573236000791 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 573236000792 P loop; other site 573236000793 GTP binding site [chemical binding]; other site 573236000794 Signal peptide binding domain; Region: SRP_SPB; pfam02978 573236000795 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 573236000796 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573236000797 active site 573236000798 HIGH motif; other site 573236000799 nucleotide binding site [chemical binding]; other site 573236000800 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 573236000801 KMSKS motif; other site 573236000802 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573236000803 tRNA binding surface [nucleotide binding]; other site 573236000804 anticodon binding site; other site 573236000805 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573236000806 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573236000807 ABC transporter; Region: ABC_tran_2; pfam12848 573236000808 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573236000809 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573236000810 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 573236000811 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 573236000812 catalytic triad [active] 573236000813 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 573236000814 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 573236000815 putative valine binding site [chemical binding]; other site 573236000816 dimer interface [polypeptide binding]; other site 573236000817 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 573236000818 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 573236000819 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573236000820 PYR/PP interface [polypeptide binding]; other site 573236000821 dimer interface [polypeptide binding]; other site 573236000822 TPP binding site [chemical binding]; other site 573236000823 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573236000824 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 573236000825 TPP-binding site [chemical binding]; other site 573236000826 dimer interface [polypeptide binding]; other site 573236000827 ribonuclease III; Reviewed; Region: rnc; PRK00102 573236000828 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 573236000829 dimerization interface [polypeptide binding]; other site 573236000830 active site 573236000831 metal binding site [ion binding]; metal-binding site 573236000832 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 573236000833 dsRNA binding site [nucleotide binding]; other site 573236000834 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 573236000835 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 573236000836 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 573236000837 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 573236000838 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 573236000839 active site 573236000840 (T/H)XGH motif; other site 573236000841 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 573236000842 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573236000843 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573236000844 active site 573236000845 catalytic tetrad [active] 573236000846 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 573236000847 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 573236000848 active site 573236000849 Ribonuclease PH; Region: RNase_PH_bact; cd11362 573236000850 ribonuclease PH; Reviewed; Region: rph; PRK00173 573236000851 hexamer interface [polypeptide binding]; other site 573236000852 active site 573236000853 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 573236000854 active site 573236000855 dimerization interface [polypeptide binding]; other site 573236000856 FemAB family; Region: FemAB; pfam02388 573236000857 Membrane transport protein; Region: Mem_trans; cl09117 573236000858 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 573236000859 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 573236000860 Substrate binding site; other site 573236000861 Cupin domain; Region: Cupin_2; cl17218 573236000862 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 573236000863 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 573236000864 active site 573236000865 dimer interface [polypeptide binding]; other site 573236000866 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 573236000867 dimer interface [polypeptide binding]; other site 573236000868 active site 573236000869 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 573236000870 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 573236000871 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 573236000872 Catalytic site [active] 573236000873 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 573236000874 RNA/DNA hybrid binding site [nucleotide binding]; other site 573236000875 active site 573236000876 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 573236000877 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573236000878 Walker A/P-loop; other site 573236000879 ATP binding site [chemical binding]; other site 573236000880 Q-loop/lid; other site 573236000881 ABC transporter signature motif; other site 573236000882 Walker B; other site 573236000883 D-loop; other site 573236000884 H-loop/switch region; other site 573236000885 FtsX-like permease family; Region: FtsX; pfam02687 573236000886 Predicted permeases [General function prediction only]; Region: COG0679 573236000887 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 573236000888 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 573236000889 metal binding site [ion binding]; metal-binding site 573236000890 putative dimer interface [polypeptide binding]; other site 573236000891 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 573236000892 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 573236000893 homodimer interface [polypeptide binding]; other site 573236000894 oligonucleotide binding site [chemical binding]; other site 573236000895 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 573236000896 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 573236000897 GTPase CgtA; Reviewed; Region: obgE; PRK12296 573236000898 GTP1/OBG; Region: GTP1_OBG; pfam01018 573236000899 Obg GTPase; Region: Obg; cd01898 573236000900 G1 box; other site 573236000901 GTP/Mg2+ binding site [chemical binding]; other site 573236000902 Switch I region; other site 573236000903 G2 box; other site 573236000904 G3 box; other site 573236000905 Switch II region; other site 573236000906 G4 box; other site 573236000907 G5 box; other site 573236000908 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 573236000909 gamma-glutamyl kinase; Provisional; Region: PRK05429 573236000910 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 573236000911 nucleotide binding site [chemical binding]; other site 573236000912 homotetrameric interface [polypeptide binding]; other site 573236000913 putative phosphate binding site [ion binding]; other site 573236000914 putative allosteric binding site; other site 573236000915 PUA domain; Region: PUA; pfam01472 573236000916 aspartate aminotransferase; Provisional; Region: PRK05764 573236000917 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236000918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236000919 homodimer interface [polypeptide binding]; other site 573236000920 catalytic residue [active] 573236000921 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 573236000922 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 573236000923 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 573236000924 putative homodimer interface [polypeptide binding]; other site 573236000925 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 573236000926 heterodimer interface [polypeptide binding]; other site 573236000927 homodimer interface [polypeptide binding]; other site 573236000928 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 573236000929 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 573236000930 23S rRNA interface [nucleotide binding]; other site 573236000931 L7/L12 interface [polypeptide binding]; other site 573236000932 putative thiostrepton binding site; other site 573236000933 L25 interface [polypeptide binding]; other site 573236000934 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 573236000935 mRNA/rRNA interface [nucleotide binding]; other site 573236000936 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 573236000937 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 573236000938 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 573236000939 BioY family; Region: BioY; pfam02632 573236000940 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 573236000941 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573236000942 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573236000943 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 573236000944 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 573236000945 carboxyltransferase (CT) interaction site; other site 573236000946 biotinylation site [posttranslational modification]; other site 573236000947 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 573236000948 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 573236000949 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 573236000950 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573236000951 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 573236000952 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 573236000953 FMN binding site [chemical binding]; other site 573236000954 substrate binding site [chemical binding]; other site 573236000955 putative catalytic residue [active] 573236000956 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 573236000957 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 573236000958 active site 2 [active] 573236000959 active site 1 [active] 573236000960 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 573236000961 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 573236000962 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 573236000963 putative NAD(P) binding site [chemical binding]; other site 573236000964 active site 573236000965 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 573236000966 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 573236000967 active site 573236000968 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 573236000969 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 573236000970 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 573236000971 NAD binding site [chemical binding]; other site 573236000972 dimer interface [polypeptide binding]; other site 573236000973 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573236000974 substrate binding site [chemical binding]; other site 573236000975 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 573236000976 16S/18S rRNA binding site [nucleotide binding]; other site 573236000977 S13e-L30e interaction site [polypeptide binding]; other site 573236000978 25S rRNA binding site [nucleotide binding]; other site 573236000979 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 573236000980 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 573236000981 oligomer interface [polypeptide binding]; other site 573236000982 RNA binding site [nucleotide binding]; other site 573236000983 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 573236000984 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 573236000985 RNase E interface [polypeptide binding]; other site 573236000986 trimer interface [polypeptide binding]; other site 573236000987 active site 573236000988 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 573236000989 putative nucleic acid binding region [nucleotide binding]; other site 573236000990 G-X-X-G motif; other site 573236000991 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 573236000992 RNA binding site [nucleotide binding]; other site 573236000993 domain interface; other site 573236000994 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 573236000995 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 573236000996 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 573236000997 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 573236000998 dimer interface [polypeptide binding]; other site 573236000999 putative radical transfer pathway; other site 573236001000 diiron center [ion binding]; other site 573236001001 tyrosyl radical; other site 573236001002 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 573236001003 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 573236001004 Class I ribonucleotide reductase; Region: RNR_I; cd01679 573236001005 active site 573236001006 dimer interface [polypeptide binding]; other site 573236001007 catalytic residues [active] 573236001008 effector binding site; other site 573236001009 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 573236001010 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 573236001011 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 573236001012 catalytic residues [active] 573236001013 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573236001014 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573236001015 active site 573236001016 catalytic tetrad [active] 573236001017 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 573236001018 Peptidase family U32; Region: Peptidase_U32; pfam01136 573236001019 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 573236001020 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 573236001021 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 573236001022 substrate binding site; other site 573236001023 dimer interface; other site 573236001024 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 573236001025 putative substrate binding pocket [chemical binding]; other site 573236001026 AC domain interface; other site 573236001027 catalytic triad [active] 573236001028 AB domain interface; other site 573236001029 interchain disulfide; other site 573236001030 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 573236001031 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 573236001032 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 573236001033 trimer interface [polypeptide binding]; other site 573236001034 active site 573236001035 G bulge; other site 573236001036 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 573236001037 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573236001038 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 573236001039 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 573236001040 catalytic triad [active] 573236001041 catalytic triad [active] 573236001042 oxyanion hole [active] 573236001043 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 573236001044 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 573236001045 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 573236001046 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 573236001047 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573236001048 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573236001049 dimer interface [polypeptide binding]; other site 573236001050 phosphorylation site [posttranslational modification] 573236001051 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573236001052 ATP binding site [chemical binding]; other site 573236001053 Mg2+ binding site [ion binding]; other site 573236001054 G-X-G motif; other site 573236001055 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573236001056 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573236001057 active site 573236001058 phosphorylation site [posttranslational modification] 573236001059 intermolecular recognition site; other site 573236001060 dimerization interface [polypeptide binding]; other site 573236001061 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573236001062 DNA binding site [nucleotide binding] 573236001063 PBP superfamily domain; Region: PBP_like_2; cl17296 573236001064 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 573236001065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236001066 dimer interface [polypeptide binding]; other site 573236001067 conserved gate region; other site 573236001068 putative PBP binding loops; other site 573236001069 ABC-ATPase subunit interface; other site 573236001070 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 573236001071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236001072 dimer interface [polypeptide binding]; other site 573236001073 conserved gate region; other site 573236001074 putative PBP binding loops; other site 573236001075 ABC-ATPase subunit interface; other site 573236001076 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 573236001077 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 573236001078 Walker A/P-loop; other site 573236001079 ATP binding site [chemical binding]; other site 573236001080 Q-loop/lid; other site 573236001081 ABC transporter signature motif; other site 573236001082 Walker B; other site 573236001083 D-loop; other site 573236001084 H-loop/switch region; other site 573236001085 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 573236001086 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573236001087 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 573236001088 intersubunit interface [polypeptide binding]; other site 573236001089 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 573236001090 23S rRNA interface [nucleotide binding]; other site 573236001091 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 573236001092 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 573236001093 peripheral dimer interface [polypeptide binding]; other site 573236001094 core dimer interface [polypeptide binding]; other site 573236001095 L10 interface [polypeptide binding]; other site 573236001096 L11 interface [polypeptide binding]; other site 573236001097 putative EF-Tu interaction site [polypeptide binding]; other site 573236001098 putative EF-G interaction site [polypeptide binding]; other site 573236001099 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 573236001100 phosphopeptide binding site; other site 573236001101 Part of AAA domain; Region: AAA_19; pfam13245 573236001102 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 573236001103 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 573236001104 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 573236001105 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 573236001106 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 573236001107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573236001108 Coenzyme A binding pocket [chemical binding]; other site 573236001109 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 573236001110 oligomerisation interface [polypeptide binding]; other site 573236001111 mobile loop; other site 573236001112 roof hairpin; other site 573236001113 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 573236001114 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 573236001115 FAD binding domain; Region: FAD_binding_4; pfam01565 573236001116 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 573236001117 amino acid transporter; Region: 2A0306; TIGR00909 573236001118 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 573236001119 Ferredoxin [Energy production and conversion]; Region: COG1146 573236001120 4Fe-4S binding domain; Region: Fer4; pfam00037 573236001121 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 573236001122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236001123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236001124 homodimer interface [polypeptide binding]; other site 573236001125 catalytic residue [active] 573236001126 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 573236001127 active site 573236001128 DNA polymerase IV; Validated; Region: PRK02406 573236001129 DNA binding site [nucleotide binding] 573236001130 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 573236001131 dimerization interface [polypeptide binding]; other site 573236001132 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 573236001133 NAD binding site [chemical binding]; other site 573236001134 ligand binding site [chemical binding]; other site 573236001135 catalytic site [active] 573236001136 Uncharacterized conserved protein [Function unknown]; Region: COG1739 573236001137 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 573236001138 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 573236001139 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 573236001140 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 573236001141 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 573236001142 23S rRNA interface [nucleotide binding]; other site 573236001143 L3 interface [polypeptide binding]; other site 573236001144 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 573236001145 pullulanase, type I; Region: pulA_typeI; TIGR02104 573236001146 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 573236001147 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 573236001148 active site 573236001149 catalytic site [active] 573236001150 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 573236001151 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573236001152 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573236001153 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 573236001154 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 573236001155 putative catalytic cysteine [active] 573236001156 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 573236001157 putative active site [active] 573236001158 metal binding site [ion binding]; metal-binding site 573236001159 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 573236001160 YwiC-like protein; Region: YwiC; pfam14256 573236001161 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 573236001162 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 573236001163 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 573236001164 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 573236001165 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 573236001166 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 573236001167 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 573236001168 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 573236001169 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 573236001170 protein-rRNA interface [nucleotide binding]; other site 573236001171 putative translocon binding site; other site 573236001172 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 573236001173 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 573236001174 G-X-X-G motif; other site 573236001175 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 573236001176 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 573236001177 23S rRNA interface [nucleotide binding]; other site 573236001178 5S rRNA interface [nucleotide binding]; other site 573236001179 putative antibiotic binding site [chemical binding]; other site 573236001180 L25 interface [polypeptide binding]; other site 573236001181 L27 interface [polypeptide binding]; other site 573236001182 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 573236001183 23S rRNA interface [nucleotide binding]; other site 573236001184 putative translocon interaction site; other site 573236001185 signal recognition particle (SRP54) interaction site; other site 573236001186 L23 interface [polypeptide binding]; other site 573236001187 trigger factor interaction site; other site 573236001188 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 573236001189 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 573236001190 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 573236001191 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 573236001192 RNA binding site [nucleotide binding]; other site 573236001193 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 573236001194 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 573236001195 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 573236001196 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 573236001197 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 573236001198 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 573236001199 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573236001200 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 573236001201 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 573236001202 23S rRNA interface [nucleotide binding]; other site 573236001203 L21e interface [polypeptide binding]; other site 573236001204 5S rRNA interface [nucleotide binding]; other site 573236001205 L27 interface [polypeptide binding]; other site 573236001206 L5 interface [polypeptide binding]; other site 573236001207 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 573236001208 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 573236001209 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 573236001210 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 573236001211 23S rRNA binding site [nucleotide binding]; other site 573236001212 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 573236001213 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 573236001214 SecY translocase; Region: SecY; pfam00344 573236001215 adenylate kinase; Reviewed; Region: adk; PRK00279 573236001216 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 573236001217 AMP-binding site [chemical binding]; other site 573236001218 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 573236001219 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 573236001220 rRNA binding site [nucleotide binding]; other site 573236001221 predicted 30S ribosome binding site; other site 573236001222 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 573236001223 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 573236001224 30S ribosomal protein S13; Region: bact_S13; TIGR03631 573236001225 30S ribosomal protein S11; Validated; Region: PRK05309 573236001226 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 573236001227 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 573236001228 alphaNTD homodimer interface [polypeptide binding]; other site 573236001229 alphaNTD - beta interaction site [polypeptide binding]; other site 573236001230 alphaNTD - beta' interaction site [polypeptide binding]; other site 573236001231 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 573236001232 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 573236001233 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 573236001234 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 573236001235 active site 573236001236 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 573236001237 NusA N-terminal domain; Region: NusA_N; pfam08529 573236001238 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 573236001239 RNA binding site [nucleotide binding]; other site 573236001240 homodimer interface [polypeptide binding]; other site 573236001241 NusA-like KH domain; Region: KH_5; pfam13184 573236001242 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 573236001243 G-X-X-G motif; other site 573236001244 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573236001245 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 573236001246 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 573236001247 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 573236001248 G1 box; other site 573236001249 putative GEF interaction site [polypeptide binding]; other site 573236001250 GTP/Mg2+ binding site [chemical binding]; other site 573236001251 Switch I region; other site 573236001252 G2 box; other site 573236001253 G3 box; other site 573236001254 Switch II region; other site 573236001255 G4 box; other site 573236001256 G5 box; other site 573236001257 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 573236001258 Translation-initiation factor 2; Region: IF-2; pfam11987 573236001259 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 573236001260 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 573236001261 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 573236001262 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 573236001263 RNA binding site [nucleotide binding]; other site 573236001264 active site 573236001265 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 573236001266 FAD synthetase; Region: FAD_syn; pfam06574 573236001267 active site 573236001268 nucleotide binding site [chemical binding]; other site 573236001269 HIGH motif; other site 573236001270 KMSKS motif; other site 573236001271 Riboflavin kinase; Region: Flavokinase; smart00904 573236001272 DNA repair protein RadA; Provisional; Region: PRK11823 573236001273 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573236001274 Walker A motif; other site 573236001275 ATP binding site [chemical binding]; other site 573236001276 Walker B motif; other site 573236001277 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573236001278 ADP-ribosylation factor GTPase-activating protein AGD10; Provisional; Region: PLN03114 573236001279 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 573236001280 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573236001281 active site 573236001282 dimer interface [polypeptide binding]; other site 573236001283 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 573236001284 RNA/DNA hybrid binding site [nucleotide binding]; other site 573236001285 active site 573236001286 seryl-tRNA synthetase; Provisional; Region: PRK05431 573236001287 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 573236001288 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 573236001289 dimer interface [polypeptide binding]; other site 573236001290 active site 573236001291 motif 1; other site 573236001292 motif 2; other site 573236001293 motif 3; other site 573236001294 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 573236001295 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 573236001296 phosphoglucomutase; Validated; Region: PRK07564 573236001297 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 573236001298 active site 573236001299 substrate binding site [chemical binding]; other site 573236001300 metal binding site [ion binding]; metal-binding site 573236001301 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 573236001302 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 573236001303 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573236001304 Tetratricopeptide repeat; Region: TPR_12; pfam13424 573236001305 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 573236001306 binding surface 573236001307 TPR motif; other site 573236001308 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 573236001309 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573236001310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573236001311 active site 573236001312 phosphorylation site [posttranslational modification] 573236001313 intermolecular recognition site; other site 573236001314 dimerization interface [polypeptide binding]; other site 573236001315 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573236001316 DNA binding residues [nucleotide binding] 573236001317 dimerization interface [polypeptide binding]; other site 573236001318 PspC domain; Region: PspC; pfam04024 573236001319 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573236001320 PspC domain; Region: PspC; pfam04024 573236001321 IncA protein; Region: IncA; pfam04156 573236001322 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 573236001323 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573236001324 homodimer interface [polypeptide binding]; other site 573236001325 substrate-cofactor binding pocket; other site 573236001326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236001327 catalytic residue [active] 573236001328 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 573236001329 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573236001330 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573236001331 catalytic residue [active] 573236001332 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 573236001333 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573236001334 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 573236001335 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 573236001336 dimer interface [polypeptide binding]; other site 573236001337 putative anticodon binding site; other site 573236001338 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573236001339 motif 1; other site 573236001340 dimer interface [polypeptide binding]; other site 573236001341 active site 573236001342 motif 2; other site 573236001343 motif 3; other site 573236001344 Phospholipase B; Region: Phospholip_B; pfam04916 573236001345 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 573236001346 trimer interface [polypeptide binding]; other site 573236001347 active site 573236001348 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 573236001349 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 573236001350 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 573236001351 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 573236001352 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 573236001353 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 573236001354 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 573236001355 UbiA prenyltransferase family; Region: UbiA; pfam01040 573236001356 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236001357 catalytic core [active] 573236001358 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236001359 myosin-cross-reactive antigen; Provisional; Region: PRK13977 573236001360 mannose-6-phosphate isomerase; Region: PLN02288 573236001361 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 573236001362 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 573236001363 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 573236001364 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573236001365 ATP binding site [chemical binding]; other site 573236001366 Mg2+ binding site [ion binding]; other site 573236001367 G-X-G motif; other site 573236001368 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 573236001369 PhoU domain; Region: PhoU; pfam01895 573236001370 PhoU domain; Region: PhoU; pfam01895 573236001371 phosphoserine aminotransferase; Provisional; Region: PRK03080 573236001372 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573236001373 catalytic residue [active] 573236001374 CHAP domain; Region: CHAP; pfam05257 573236001375 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 573236001376 NlpC/P60 family; Region: NLPC_P60; cl17555 573236001377 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573236001378 Ligand Binding Site [chemical binding]; other site 573236001379 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573236001380 Ligand Binding Site [chemical binding]; other site 573236001381 OsmC-like protein; Region: OsmC; cl00767 573236001382 thymidylate synthase; Reviewed; Region: thyA; PRK01827 573236001383 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 573236001384 dimerization interface [polypeptide binding]; other site 573236001385 active site 573236001386 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 573236001387 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 573236001388 folate binding site [chemical binding]; other site 573236001389 NADP+ binding site [chemical binding]; other site 573236001390 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573236001391 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 573236001392 active site 573236001393 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 573236001394 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573236001395 NAD(P) binding site [chemical binding]; other site 573236001396 active site 573236001397 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 573236001398 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 573236001399 putative active site [active] 573236001400 5'-nucleotidase; Region: 5-nucleotidase; pfam06189 573236001401 serine/threonine protein kinase; Provisional; Region: PRK14879 573236001402 AAA domain; Region: AAA_21; pfam13304 573236001403 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 573236001404 putative active site [active] 573236001405 putative metal-binding site [ion binding]; other site 573236001406 Cutinase; Region: Cutinase; pfam01083 573236001407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 573236001408 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 573236001409 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 573236001410 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 573236001411 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 573236001412 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 573236001413 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 573236001414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924 573236001415 Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795 573236001416 Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983 573236001417 Uncharacterized conserved protein [Function unknown]; Region: COG3189 573236001418 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 573236001419 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 573236001420 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 573236001421 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 573236001422 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 573236001423 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 573236001424 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 573236001425 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236001426 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236001427 DNA binding site [nucleotide binding] 573236001428 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 573236001429 putative dimerization interface [polypeptide binding]; other site 573236001430 putative ligand binding site [chemical binding]; other site 573236001431 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573236001432 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236001433 motif II; other site 573236001434 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 573236001435 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 573236001436 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573236001437 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573236001438 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 573236001439 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 573236001440 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 573236001441 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 573236001442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573236001443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236001444 dimer interface [polypeptide binding]; other site 573236001445 conserved gate region; other site 573236001446 putative PBP binding loops; other site 573236001447 ABC-ATPase subunit interface; other site 573236001448 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236001449 dimer interface [polypeptide binding]; other site 573236001450 conserved gate region; other site 573236001451 putative PBP binding loops; other site 573236001452 ABC-ATPase subunit interface; other site 573236001453 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236001454 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236001455 DNA binding site [nucleotide binding] 573236001456 domain linker motif; other site 573236001457 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 573236001458 ligand binding site [chemical binding]; other site 573236001459 dimerization interface (open form) [polypeptide binding]; other site 573236001460 dimerization interface (closed form) [polypeptide binding]; other site 573236001461 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573236001462 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573236001463 active site 573236001464 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 573236001465 Domain of unknown function DUF20; Region: UPF0118; pfam01594 573236001466 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573236001467 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 573236001468 DXD motif; other site 573236001469 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 573236001470 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573236001471 Walker A/P-loop; other site 573236001472 ATP binding site [chemical binding]; other site 573236001473 Q-loop/lid; other site 573236001474 ABC transporter signature motif; other site 573236001475 Walker B; other site 573236001476 D-loop; other site 573236001477 H-loop/switch region; other site 573236001478 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 573236001479 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 573236001480 Ligand Binding Site [chemical binding]; other site 573236001481 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573236001482 active site 573236001483 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 573236001484 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236001485 Walker A motif; other site 573236001486 ATP binding site [chemical binding]; other site 573236001487 Walker B motif; other site 573236001488 arginine finger; other site 573236001489 Peptidase family M41; Region: Peptidase_M41; pfam01434 573236001490 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 573236001491 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 573236001492 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 573236001493 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 573236001494 active site 573236001495 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 573236001496 catalytic triad [active] 573236001497 dimer interface [polypeptide binding]; other site 573236001498 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 573236001499 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573236001500 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573236001501 ABC transporter; Region: ABC_tran_2; pfam12848 573236001502 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573236001503 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573236001504 active site 573236001505 catalytic residues [active] 573236001506 metal binding site [ion binding]; metal-binding site 573236001507 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 573236001508 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573236001509 homodimer interface [polypeptide binding]; other site 573236001510 substrate-cofactor binding pocket; other site 573236001511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236001512 catalytic residue [active] 573236001513 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 573236001514 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 573236001515 xylose isomerase; Provisional; Region: PRK05474 573236001516 xylose isomerase; Region: xylose_isom_A; TIGR02630 573236001517 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 573236001518 active site 573236001519 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236001520 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236001521 DNA binding site [nucleotide binding] 573236001522 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 573236001523 putative ligand binding site [chemical binding]; other site 573236001524 putative dimerization interface [polypeptide binding]; other site 573236001525 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 573236001526 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573236001527 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573236001528 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236001529 dimer interface [polypeptide binding]; other site 573236001530 conserved gate region; other site 573236001531 putative PBP binding loops; other site 573236001532 ABC-ATPase subunit interface; other site 573236001533 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573236001534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236001535 dimer interface [polypeptide binding]; other site 573236001536 conserved gate region; other site 573236001537 putative PBP binding loops; other site 573236001538 ABC-ATPase subunit interface; other site 573236001539 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573236001540 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 573236001541 inhibitor binding site; inhibition site 573236001542 active site 573236001543 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573236001544 Domain of unknown function (DUF303); Region: DUF303; pfam03629 573236001545 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573236001546 Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272 573236001547 substrate binding pocket [chemical binding]; other site 573236001548 catalytic triad [active] 573236001549 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573236001550 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 573236001551 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_2; cd09001 573236001552 active site 573236001553 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573236001554 D-xylulose kinase; Region: XylB; TIGR01312 573236001555 nucleotide binding site [chemical binding]; other site 573236001556 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 573236001557 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573236001558 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573236001559 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 573236001560 peptide chain release factor 1; Validated; Region: prfA; PRK00591 573236001561 PCRF domain; Region: PCRF; pfam03462 573236001562 RF-1 domain; Region: RF-1; pfam00472 573236001563 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 573236001564 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 573236001565 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 573236001566 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 573236001567 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 573236001568 Mg++ binding site [ion binding]; other site 573236001569 putative catalytic motif [active] 573236001570 substrate binding site [chemical binding]; other site 573236001571 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 573236001572 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573236001573 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 573236001574 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 573236001575 active site 573236001576 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 573236001577 catalytic site [active] 573236001578 putative active site [active] 573236001579 putative substrate binding site [chemical binding]; other site 573236001580 dimer interface [polypeptide binding]; other site 573236001581 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236001582 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573236001583 active site 573236001584 motif I; other site 573236001585 motif II; other site 573236001586 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573236001587 AAA domain; Region: AAA_30; pfam13604 573236001588 PIF1-like helicase; Region: PIF1; pfam05970 573236001589 Protein of unknown function (DUF805); Region: DUF805; cl01224 573236001590 prolyl-tRNA synthetase; Provisional; Region: PRK09194 573236001591 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 573236001592 dimer interface [polypeptide binding]; other site 573236001593 motif 1; other site 573236001594 active site 573236001595 motif 2; other site 573236001596 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 573236001597 putative deacylase active site [active] 573236001598 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573236001599 active site 573236001600 motif 3; other site 573236001601 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 573236001602 anticodon binding site; other site 573236001603 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573236001604 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573236001605 dimer interface [polypeptide binding]; other site 573236001606 ssDNA binding site [nucleotide binding]; other site 573236001607 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573236001608 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 573236001609 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 573236001610 active site 573236001611 Zn binding site [ion binding]; other site 573236001612 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 573236001613 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 573236001614 active site 573236001615 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 573236001616 Citrate synthase; Region: Citrate_synt; pfam00285 573236001617 oxalacetate binding site [chemical binding]; other site 573236001618 citrylCoA binding site [chemical binding]; other site 573236001619 coenzyme A binding site [chemical binding]; other site 573236001620 catalytic triad [active] 573236001621 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 573236001622 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 573236001623 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 573236001624 putative trimer interface [polypeptide binding]; other site 573236001625 putative CoA binding site [chemical binding]; other site 573236001626 peptide chain release factor 2; Validated; Region: prfB; PRK00578 573236001627 This domain is found in peptide chain release factors; Region: PCRF; smart00937 573236001628 RF-1 domain; Region: RF-1; pfam00472 573236001629 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 573236001630 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236001631 Walker A/P-loop; other site 573236001632 ATP binding site [chemical binding]; other site 573236001633 Q-loop/lid; other site 573236001634 ABC transporter signature motif; other site 573236001635 Walker B; other site 573236001636 D-loop; other site 573236001637 H-loop/switch region; other site 573236001638 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 573236001639 FtsX-like permease family; Region: FtsX; pfam02687 573236001640 Surface antigen [General function prediction only]; Region: COG3942 573236001641 CHAP domain; Region: CHAP; pfam05257 573236001642 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 573236001643 SmpB-tmRNA interface; other site 573236001644 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573236001645 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573236001646 substrate binding pocket [chemical binding]; other site 573236001647 membrane-bound complex binding site; other site 573236001648 hinge residues; other site 573236001649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573236001650 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573236001651 substrate binding pocket [chemical binding]; other site 573236001652 membrane-bound complex binding site; other site 573236001653 hinge residues; other site 573236001654 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573236001655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236001656 dimer interface [polypeptide binding]; other site 573236001657 conserved gate region; other site 573236001658 putative PBP binding loops; other site 573236001659 ABC-ATPase subunit interface; other site 573236001660 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573236001661 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573236001662 Walker A/P-loop; other site 573236001663 ATP binding site [chemical binding]; other site 573236001664 Q-loop/lid; other site 573236001665 ABC transporter signature motif; other site 573236001666 Walker B; other site 573236001667 D-loop; other site 573236001668 H-loop/switch region; other site 573236001669 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 573236001670 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573236001671 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573236001672 active site 573236001673 phosphorylation site [posttranslational modification] 573236001674 intermolecular recognition site; other site 573236001675 dimerization interface [polypeptide binding]; other site 573236001676 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573236001677 DNA binding residues [nucleotide binding] 573236001678 dimerization interface [polypeptide binding]; other site 573236001679 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 573236001680 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 573236001681 glutaminase active site [active] 573236001682 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 573236001683 dimer interface [polypeptide binding]; other site 573236001684 active site 573236001685 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 573236001686 dimer interface [polypeptide binding]; other site 573236001687 active site 573236001688 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573236001689 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 573236001690 active site 573236001691 pantothenate kinase; Reviewed; Region: PRK13318 573236001692 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573236001693 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 573236001694 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573236001695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236001696 dimer interface [polypeptide binding]; other site 573236001697 conserved gate region; other site 573236001698 putative PBP binding loops; other site 573236001699 ABC-ATPase subunit interface; other site 573236001700 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 573236001701 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236001702 dimer interface [polypeptide binding]; other site 573236001703 conserved gate region; other site 573236001704 putative PBP binding loops; other site 573236001705 ABC-ATPase subunit interface; other site 573236001706 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 573236001707 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573236001708 Walker A/P-loop; other site 573236001709 ATP binding site [chemical binding]; other site 573236001710 Q-loop/lid; other site 573236001711 ABC transporter signature motif; other site 573236001712 Walker B; other site 573236001713 D-loop; other site 573236001714 H-loop/switch region; other site 573236001715 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 573236001716 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573236001717 Walker A/P-loop; other site 573236001718 ATP binding site [chemical binding]; other site 573236001719 Q-loop/lid; other site 573236001720 ABC transporter signature motif; other site 573236001721 Walker B; other site 573236001722 D-loop; other site 573236001723 H-loop/switch region; other site 573236001724 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573236001725 cystathionine gamma-synthase; Provisional; Region: PRK07811 573236001726 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573236001727 homodimer interface [polypeptide binding]; other site 573236001728 substrate-cofactor binding pocket; other site 573236001729 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236001730 catalytic residue [active] 573236001731 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 573236001732 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 573236001733 dimer interface [polypeptide binding]; other site 573236001734 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236001735 catalytic residue [active] 573236001736 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573236001737 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 573236001738 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573236001739 ATP binding site [chemical binding]; other site 573236001740 ATP binding site [chemical binding]; other site 573236001741 putative Mg++ binding site [ion binding]; other site 573236001742 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236001743 nucleotide binding region [chemical binding]; other site 573236001744 ATP-binding site [chemical binding]; other site 573236001745 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 573236001746 HRDC domain; Region: HRDC; pfam00570 573236001747 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 573236001748 putative active site [active] 573236001749 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573236001750 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573236001751 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 573236001752 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 573236001753 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 573236001754 active site 573236001755 8-oxo-dGMP binding site [chemical binding]; other site 573236001756 nudix motif; other site 573236001757 metal binding site [ion binding]; metal-binding site 573236001758 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 573236001759 PLD-like domain; Region: PLDc_2; pfam13091 573236001760 putative homodimer interface [polypeptide binding]; other site 573236001761 putative active site [active] 573236001762 catalytic site [active] 573236001763 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573236001764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573236001765 ATP binding site [chemical binding]; other site 573236001766 putative Mg++ binding site [ion binding]; other site 573236001767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236001768 nucleotide binding region [chemical binding]; other site 573236001769 ATP-binding site [chemical binding]; other site 573236001770 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 573236001771 Fic family protein [Function unknown]; Region: COG3177 573236001772 Protein of unknown function DUF262; Region: DUF262; pfam03235 573236001773 Uncharacterized conserved protein [Function unknown]; Region: COG1479 573236001774 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 573236001775 Protein of unknown function (DUF4065); Region: DUF4065; pfam13274 573236001776 Fic/DOC family; Region: Fic; cl00960 573236001777 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 573236001778 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573236001779 Coenzyme A binding pocket [chemical binding]; other site 573236001780 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 573236001781 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 573236001782 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 573236001783 putative active site [active] 573236001784 metal binding site [ion binding]; metal-binding site 573236001785 S-ribosylhomocysteinase; Provisional; Region: PRK02260 573236001786 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 573236001787 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 573236001788 alanine racemase; Reviewed; Region: alr; PRK00053 573236001789 active site 573236001790 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573236001791 dimer interface [polypeptide binding]; other site 573236001792 substrate binding site [chemical binding]; other site 573236001793 catalytic residues [active] 573236001794 DNA primase; Validated; Region: dnaG; PRK05667 573236001795 CHC2 zinc finger; Region: zf-CHC2; pfam01807 573236001796 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 573236001797 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 573236001798 active site 573236001799 metal binding site [ion binding]; metal-binding site 573236001800 interdomain interaction site; other site 573236001801 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 573236001802 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 573236001803 transmembrane helices; other site 573236001804 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 573236001805 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 573236001806 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 573236001807 TPP-binding site; other site 573236001808 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573236001809 PYR/PP interface [polypeptide binding]; other site 573236001810 dimer interface [polypeptide binding]; other site 573236001811 TPP binding site [chemical binding]; other site 573236001812 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573236001813 AIR carboxylase; Region: AIRC; pfam00731 573236001814 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 573236001815 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 573236001816 NAD binding site [chemical binding]; other site 573236001817 ATP-grasp domain; Region: ATP-grasp; pfam02222 573236001818 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 573236001819 metal binding site 2 [ion binding]; metal-binding site 573236001820 putative DNA binding helix; other site 573236001821 metal binding site 1 [ion binding]; metal-binding site 573236001822 dimer interface [polypeptide binding]; other site 573236001823 structural Zn2+ binding site [ion binding]; other site 573236001824 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 573236001825 Putative esterase; Region: Esterase; pfam00756 573236001826 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 573236001827 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 573236001828 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 573236001829 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 573236001830 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 573236001831 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 573236001832 dimerization interface [polypeptide binding]; other site 573236001833 putative ATP binding site [chemical binding]; other site 573236001834 amidophosphoribosyltransferase; Provisional; Region: PRK07272 573236001835 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 573236001836 active site 573236001837 tetramer interface [polypeptide binding]; other site 573236001838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573236001839 active site 573236001840 Y-family of DNA polymerases; Region: PolY; cl12025 573236001841 DNA polymerase IV; Reviewed; Region: PRK03103 573236001842 active site 573236001843 DNA binding site [nucleotide binding] 573236001844 Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597 573236001845 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 573236001846 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 573236001847 Short C-terminal domain; Region: SHOCT; pfam09851 573236001848 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 573236001849 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 573236001850 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 573236001851 dimerization interface [polypeptide binding]; other site 573236001852 ATP binding site [chemical binding]; other site 573236001853 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 573236001854 dimerization interface [polypeptide binding]; other site 573236001855 ATP binding site [chemical binding]; other site 573236001856 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 573236001857 conserved cys residue [active] 573236001858 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 573236001859 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 573236001860 ATP binding site [chemical binding]; other site 573236001861 active site 573236001862 substrate binding site [chemical binding]; other site 573236001863 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 573236001864 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573236001865 ATP-grasp domain; Region: ATP-grasp; pfam02222 573236001866 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573236001867 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573236001868 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 573236001869 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 573236001870 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573236001871 catalytic residue [active] 573236001872 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 573236001873 16S rRNA interaction site [nucleotide binding]; other site 573236001874 streptomycin interaction site [chemical binding]; other site 573236001875 23S rRNA interaction site [nucleotide binding]; other site 573236001876 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 573236001877 30S ribosomal protein S7; Validated; Region: PRK05302 573236001878 elongation factor G; Reviewed; Region: PRK00007 573236001879 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 573236001880 G1 box; other site 573236001881 putative GEF interaction site [polypeptide binding]; other site 573236001882 GTP/Mg2+ binding site [chemical binding]; other site 573236001883 Switch I region; other site 573236001884 G2 box; other site 573236001885 G3 box; other site 573236001886 Switch II region; other site 573236001887 G4 box; other site 573236001888 G5 box; other site 573236001889 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573236001890 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 573236001891 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 573236001892 elongation factor Tu; Reviewed; Region: PRK00049 573236001893 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 573236001894 G1 box; other site 573236001895 GEF interaction site [polypeptide binding]; other site 573236001896 GTP/Mg2+ binding site [chemical binding]; other site 573236001897 Switch I region; other site 573236001898 G2 box; other site 573236001899 G3 box; other site 573236001900 Switch II region; other site 573236001901 G4 box; other site 573236001902 G5 box; other site 573236001903 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 573236001904 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 573236001905 Antibiotic Binding Site [chemical binding]; other site 573236001906 Plant phosphoribosyltransferase C-terminal; Region: PRT_C; pfam08372 573236001907 elongation factor P; Validated; Region: PRK00529 573236001908 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 573236001909 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 573236001910 RNA binding site [nucleotide binding]; other site 573236001911 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 573236001912 RNA binding site [nucleotide binding]; other site 573236001913 transcription antitermination factor NusB; Region: nusB; TIGR01951 573236001914 putative RNA binding site [nucleotide binding]; other site 573236001915 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 573236001916 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 573236001917 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 573236001918 catalytic site [active] 573236001919 subunit interface [polypeptide binding]; other site 573236001920 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 573236001921 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573236001922 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573236001923 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 573236001924 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 573236001925 ATP-grasp domain; Region: ATP-grasp_4; cl17255 573236001926 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 573236001927 IMP binding site; other site 573236001928 dimer interface [polypeptide binding]; other site 573236001929 interdomain contacts; other site 573236001930 partial ornithine binding site; other site 573236001931 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 573236001932 active site 573236001933 dimer interface [polypeptide binding]; other site 573236001934 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 573236001935 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 573236001936 catalytic site [active] 573236001937 G-X2-G-X-G-K; other site 573236001938 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 573236001939 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 573236001940 S-adenosylmethionine synthetase; Validated; Region: PRK05250 573236001941 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 573236001942 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 573236001943 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 573236001944 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 573236001945 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573236001946 S-adenosylmethionine binding site [chemical binding]; other site 573236001947 primosome assembly protein PriA; Provisional; Region: PRK14873 573236001948 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 573236001949 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 573236001950 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 573236001951 substrate binding site [chemical binding]; other site 573236001952 putative active site [active] 573236001953 putative cosubstrate binding site; other site 573236001954 catalytic site [active] 573236001955 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 573236001956 substrate binding site [chemical binding]; other site 573236001957 phosphoserine phosphatase SerB; Region: serB; TIGR00338 573236001958 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236001959 motif II; other site 573236001960 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573236001961 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 573236001962 proteasome ATPase; Region: pup_AAA; TIGR03689 573236001963 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236001964 Walker A motif; other site 573236001965 ATP binding site [chemical binding]; other site 573236001966 Walker B motif; other site 573236001967 arginine finger; other site 573236001968 Pup-ligase protein; Region: Pup_ligase; cl15463 573236001969 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 573236001970 active site 573236001971 Pup-like protein; Region: Pup; cl05289 573236001972 Pup-ligase protein; Region: Pup_ligase; cl15463 573236001973 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 573236001974 IHF dimer interface [polypeptide binding]; other site 573236001975 IHF - DNA interface [nucleotide binding]; other site 573236001976 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 573236001977 adenylosuccinate lyase; Provisional; Region: PRK09285 573236001978 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 573236001979 tetramer interface [polypeptide binding]; other site 573236001980 active site 573236001981 Secretory lipase; Region: LIP; pfam03583 573236001982 von Willebrand factor type A domain; Region: VWA_2; pfam13519 573236001983 metal ion-dependent adhesion site (MIDAS); other site 573236001984 von Willebrand factor type A domain; Region: VWA_2; pfam13519 573236001985 metal ion-dependent adhesion site (MIDAS); other site 573236001986 Protein of unknown function DUF58; Region: DUF58; pfam01882 573236001987 MoxR-like ATPases [General function prediction only]; Region: COG0714 573236001988 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 573236001989 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 573236001990 ligand binding site [chemical binding]; other site 573236001991 active site 573236001992 UGI interface [polypeptide binding]; other site 573236001993 catalytic site [active] 573236001994 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 573236001995 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573236001996 DNA-binding site [nucleotide binding]; DNA binding site 573236001997 RNA-binding motif; other site 573236001998 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 573236001999 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 573236002000 ring oligomerisation interface [polypeptide binding]; other site 573236002001 ATP/Mg binding site [chemical binding]; other site 573236002002 stacking interactions; other site 573236002003 hinge regions; other site 573236002004 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 573236002005 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573236002006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573236002007 active site 573236002008 phosphorylation site [posttranslational modification] 573236002009 intermolecular recognition site; other site 573236002010 dimerization interface [polypeptide binding]; other site 573236002011 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573236002012 DNA binding site [nucleotide binding] 573236002013 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573236002014 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573236002015 dimerization interface [polypeptide binding]; other site 573236002016 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573236002017 dimer interface [polypeptide binding]; other site 573236002018 phosphorylation site [posttranslational modification] 573236002019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573236002020 ATP binding site [chemical binding]; other site 573236002021 Mg2+ binding site [ion binding]; other site 573236002022 G-X-G motif; other site 573236002023 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 573236002024 DNA-binding site [nucleotide binding]; DNA binding site 573236002025 RNA-binding motif; other site 573236002026 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 573236002027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573236002028 Ligand Binding Site [chemical binding]; other site 573236002029 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 573236002030 Ligand Binding Site [chemical binding]; other site 573236002031 Clp protease ATP binding subunit; Region: clpC; CHL00095 573236002032 Clp amino terminal domain; Region: Clp_N; pfam02861 573236002033 Clp amino terminal domain; Region: Clp_N; pfam02861 573236002034 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236002035 Walker A motif; other site 573236002036 ATP binding site [chemical binding]; other site 573236002037 Walker B motif; other site 573236002038 arginine finger; other site 573236002039 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236002040 Walker A motif; other site 573236002041 ATP binding site [chemical binding]; other site 573236002042 Walker B motif; other site 573236002043 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573236002044 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 573236002045 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 573236002046 dimer interface [polypeptide binding]; other site 573236002047 anticodon binding site; other site 573236002048 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573236002049 motif 1; other site 573236002050 dimer interface [polypeptide binding]; other site 573236002051 active site 573236002052 motif 2; other site 573236002053 GAD domain; Region: GAD; pfam02938 573236002054 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573236002055 active site 573236002056 motif 3; other site 573236002057 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 573236002058 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 573236002059 dimer interface [polypeptide binding]; other site 573236002060 motif 1; other site 573236002061 active site 573236002062 motif 2; other site 573236002063 motif 3; other site 573236002064 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 573236002065 anticodon binding site; other site 573236002066 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 573236002067 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 573236002068 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 573236002069 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573236002070 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 573236002071 catalytic site [active] 573236002072 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573236002073 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 573236002074 Walker A/P-loop; other site 573236002075 ATP binding site [chemical binding]; other site 573236002076 Q-loop/lid; other site 573236002077 ABC transporter signature motif; other site 573236002078 Walker B; other site 573236002079 D-loop; other site 573236002080 H-loop/switch region; other site 573236002081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573236002082 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573236002083 substrate binding pocket [chemical binding]; other site 573236002084 membrane-bound complex binding site; other site 573236002085 hinge residues; other site 573236002086 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236002087 dimer interface [polypeptide binding]; other site 573236002088 conserved gate region; other site 573236002089 ABC-ATPase subunit interface; other site 573236002090 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573236002091 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236002092 dimer interface [polypeptide binding]; other site 573236002093 conserved gate region; other site 573236002094 putative PBP binding loops; other site 573236002095 ABC-ATPase subunit interface; other site 573236002096 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 573236002097 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573236002098 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573236002099 ATP binding site [chemical binding]; other site 573236002100 putative Mg++ binding site [ion binding]; other site 573236002101 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236002102 nucleotide binding region [chemical binding]; other site 573236002103 ATP-binding site [chemical binding]; other site 573236002104 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 573236002105 recombination factor protein RarA; Reviewed; Region: PRK13342 573236002106 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236002107 Walker A motif; other site 573236002108 ATP binding site [chemical binding]; other site 573236002109 Walker B motif; other site 573236002110 arginine finger; other site 573236002111 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 573236002112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236002113 putative substrate translocation pore; other site 573236002114 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236002115 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573236002116 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573236002117 acyl-activating enzyme (AAE) consensus motif; other site 573236002118 putative AMP binding site [chemical binding]; other site 573236002119 putative active site [active] 573236002120 putative CoA binding site [chemical binding]; other site 573236002121 Transposase, Mutator family; Region: Transposase_mut; pfam00872 573236002122 MULE transposase domain; Region: MULE; pfam10551 573236002123 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573236002124 Coenzyme A binding pocket [chemical binding]; other site 573236002125 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 573236002126 hypothetical protein; Provisional; Region: PRK11770 573236002127 Domain of unknown function (DUF307); Region: DUF307; pfam03733 573236002128 Domain of unknown function (DUF307); Region: DUF307; pfam03733 573236002129 Putative transcription activator [Transcription]; Region: TenA; COG0819 573236002130 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 573236002131 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 573236002132 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 573236002133 active site 573236002134 catalytic tetrad [active] 573236002135 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573236002136 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 573236002137 Walker A/P-loop; other site 573236002138 ATP binding site [chemical binding]; other site 573236002139 Q-loop/lid; other site 573236002140 ABC transporter signature motif; other site 573236002141 Walker B; other site 573236002142 D-loop; other site 573236002143 H-loop/switch region; other site 573236002144 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573236002145 Walker A/P-loop; other site 573236002146 ATP binding site [chemical binding]; other site 573236002147 Q-loop/lid; other site 573236002148 ABC transporter signature motif; other site 573236002149 Walker B; other site 573236002150 D-loop; other site 573236002151 H-loop/switch region; other site 573236002152 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573236002153 Predicted membrane protein [Function unknown]; Region: COG3601 573236002154 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573236002155 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573236002156 nucleotide binding site [chemical binding]; other site 573236002157 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236002158 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236002159 homodimer interface [polypeptide binding]; other site 573236002160 catalytic residue [active] 573236002161 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573236002162 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236002163 Walker A/P-loop; other site 573236002164 ATP binding site [chemical binding]; other site 573236002165 Q-loop/lid; other site 573236002166 ABC transporter signature motif; other site 573236002167 Walker B; other site 573236002168 D-loop; other site 573236002169 H-loop/switch region; other site 573236002170 Ligase N family; Region: LIGANc; smart00532 573236002171 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 573236002172 nucleotide binding pocket [chemical binding]; other site 573236002173 K-X-D-G motif; other site 573236002174 catalytic site [active] 573236002175 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 573236002176 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 573236002177 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 573236002178 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 573236002179 Dimer interface [polypeptide binding]; other site 573236002180 Domain of unknown function DUF59; Region: DUF59; cl00941 573236002181 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 573236002182 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 573236002183 glutamine synthetase, type I; Region: GlnA; TIGR00653 573236002184 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 573236002185 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573236002186 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 573236002187 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 573236002188 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573236002189 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573236002190 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 573236002191 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 573236002192 hypothetical protein; Provisional; Region: PRK07907 573236002193 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 573236002194 active site 573236002195 metal binding site [ion binding]; metal-binding site 573236002196 dimer interface [polypeptide binding]; other site 573236002197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573236002198 Histidine kinase; Region: HisKA_3; pfam07730 573236002199 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 573236002200 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236002201 ABC transporter signature motif; other site 573236002202 Walker B; other site 573236002203 D-loop; other site 573236002204 H-loop/switch region; other site 573236002205 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 573236002206 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573236002207 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 573236002208 Walker A/P-loop; other site 573236002209 ATP binding site [chemical binding]; other site 573236002210 Q-loop/lid; other site 573236002211 ABC transporter signature motif; other site 573236002212 Walker B; other site 573236002213 D-loop; other site 573236002214 H-loop/switch region; other site 573236002215 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573236002216 Walker A/P-loop; other site 573236002217 ATP binding site [chemical binding]; other site 573236002218 Q-loop/lid; other site 573236002219 ABC transporter signature motif; other site 573236002220 Walker B; other site 573236002221 D-loop; other site 573236002222 H-loop/switch region; other site 573236002223 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573236002224 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573236002225 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573236002226 Walker A/P-loop; other site 573236002227 ATP binding site [chemical binding]; other site 573236002228 Q-loop/lid; other site 573236002229 ABC transporter signature motif; other site 573236002230 Walker B; other site 573236002231 D-loop; other site 573236002232 H-loop/switch region; other site 573236002233 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573236002234 FtsX-like permease family; Region: FtsX; pfam02687 573236002235 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 573236002236 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 573236002237 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573236002238 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 573236002239 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 573236002240 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 573236002241 dimer interface [polypeptide binding]; other site 573236002242 motif 1; other site 573236002243 active site 573236002244 motif 2; other site 573236002245 motif 3; other site 573236002246 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 573236002247 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 573236002248 putative tRNA-binding site [nucleotide binding]; other site 573236002249 B3/4 domain; Region: B3_4; pfam03483 573236002250 tRNA synthetase B5 domain; Region: B5; smart00874 573236002251 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 573236002252 dimer interface [polypeptide binding]; other site 573236002253 motif 1; other site 573236002254 motif 3; other site 573236002255 motif 2; other site 573236002256 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 573236002257 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 573236002258 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 573236002259 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 573236002260 heterotetramer interface [polypeptide binding]; other site 573236002261 active site pocket [active] 573236002262 cleavage site 573236002263 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 573236002264 feedback inhibition sensing region; other site 573236002265 homohexameric interface [polypeptide binding]; other site 573236002266 nucleotide binding site [chemical binding]; other site 573236002267 N-acetyl-L-glutamate binding site [chemical binding]; other site 573236002268 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 573236002269 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 573236002270 inhibitor-cofactor binding pocket; inhibition site 573236002271 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236002272 catalytic residue [active] 573236002273 ornithine carbamoyltransferase; Provisional; Region: PRK00779 573236002274 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573236002275 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573236002276 arginine repressor; Provisional; Region: PRK03341 573236002277 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 573236002278 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 573236002279 argininosuccinate synthase; Provisional; Region: PRK13820 573236002280 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 573236002281 ANP binding site [chemical binding]; other site 573236002282 Substrate Binding Site II [chemical binding]; other site 573236002283 Substrate Binding Site I [chemical binding]; other site 573236002284 argininosuccinate lyase; Provisional; Region: PRK00855 573236002285 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 573236002286 active sites [active] 573236002287 tetramer interface [polypeptide binding]; other site 573236002288 acetoin reductases; Region: 23BDH; TIGR02415 573236002289 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573236002290 NAD(P) binding site [chemical binding]; other site 573236002291 active site 573236002292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573236002293 Zn2+ binding site [ion binding]; other site 573236002294 Mg2+ binding site [ion binding]; other site 573236002295 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 573236002296 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 573236002297 active site 573236002298 HIGH motif; other site 573236002299 dimer interface [polypeptide binding]; other site 573236002300 KMSKS motif; other site 573236002301 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573236002302 RNA binding surface [nucleotide binding]; other site 573236002303 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 573236002304 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236002305 active site 573236002306 motif I; other site 573236002307 motif II; other site 573236002308 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236002309 motif II; other site 573236002310 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 573236002311 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573236002312 RNA binding surface [nucleotide binding]; other site 573236002313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573236002314 S-adenosylmethionine binding site [chemical binding]; other site 573236002315 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 573236002316 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 573236002317 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 573236002318 TrkA-N domain; Region: TrkA_N; pfam02254 573236002319 TrkA-C domain; Region: TrkA_C; pfam02080 573236002320 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 573236002321 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708 573236002322 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 573236002323 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573236002324 Walker A/P-loop; other site 573236002325 ATP binding site [chemical binding]; other site 573236002326 Q-loop/lid; other site 573236002327 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 573236002328 ABC transporter signature motif; other site 573236002329 Walker B; other site 573236002330 D-loop; other site 573236002331 H-loop/switch region; other site 573236002332 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 573236002333 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 573236002334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236002335 motif II; other site 573236002336 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 573236002337 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 573236002338 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236002339 catalytic residue [active] 573236002340 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 573236002341 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 573236002342 putative catalytic cysteine [active] 573236002343 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 573236002344 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 573236002345 active site 573236002346 (T/H)XGH motif; other site 573236002347 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573236002348 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 573236002349 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573236002350 active site 573236002351 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 573236002352 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 573236002353 Substrate binding site; other site 573236002354 Mg++ binding site; other site 573236002355 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 573236002356 active site 573236002357 substrate binding site [chemical binding]; other site 573236002358 CoA binding site [chemical binding]; other site 573236002359 Oligomerisation domain; Region: Oligomerisation; pfam02410 573236002360 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236002361 catalytic core [active] 573236002362 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 573236002363 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236002364 catalytic core [active] 573236002365 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 573236002366 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 573236002367 Cl binding site [ion binding]; other site 573236002368 oligomer interface [polypeptide binding]; other site 573236002369 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573236002370 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 573236002371 substrate binding pocket [chemical binding]; other site 573236002372 membrane-bound complex binding site; other site 573236002373 hinge residues; other site 573236002374 aminoacyl-tRNA ligase; Region: PLN02563 573236002375 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573236002376 active site 573236002377 HIGH motif; other site 573236002378 nucleotide binding site [chemical binding]; other site 573236002379 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573236002380 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 573236002381 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573236002382 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573236002383 active site 573236002384 KMSKS motif; other site 573236002385 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 573236002386 tRNA binding surface [nucleotide binding]; other site 573236002387 Helix-hairpin-helix motif; Region: HHH; pfam00633 573236002388 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 573236002389 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 573236002390 Competence protein; Region: Competence; pfam03772 573236002391 hypothetical protein; Reviewed; Region: PRK07914 573236002392 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 573236002393 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 573236002394 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 573236002395 Glycoprotease family; Region: Peptidase_M22; pfam00814 573236002396 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 573236002397 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573236002398 Coenzyme A binding pocket [chemical binding]; other site 573236002399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 573236002400 UGMP family protein; Validated; Region: PRK09604 573236002401 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 573236002402 Peptidase family M23; Region: Peptidase_M23; cl17043 573236002403 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573236002404 isocitrate dehydrogenase; Validated; Region: PRK08299 573236002405 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 573236002406 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 573236002407 phosphate binding site [ion binding]; other site 573236002408 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573236002409 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573236002410 acyl-activating enzyme (AAE) consensus motif; other site 573236002411 putative AMP binding site [chemical binding]; other site 573236002412 putative active site [active] 573236002413 putative CoA binding site [chemical binding]; other site 573236002414 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573236002415 active site 573236002416 catalytic residues [active] 573236002417 metal binding site [ion binding]; metal-binding site 573236002418 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 573236002419 rRNA interaction site [nucleotide binding]; other site 573236002420 S8 interaction site; other site 573236002421 putative laminin-1 binding site; other site 573236002422 elongation factor Ts; Provisional; Region: tsf; PRK09377 573236002423 UBA/TS-N domain; Region: UBA; pfam00627 573236002424 Elongation factor TS; Region: EF_TS; pfam00889 573236002425 Elongation factor TS; Region: EF_TS; pfam00889 573236002426 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 573236002427 putative nucleotide binding site [chemical binding]; other site 573236002428 uridine monophosphate binding site [chemical binding]; other site 573236002429 homohexameric interface [polypeptide binding]; other site 573236002430 ribosome recycling factor; Reviewed; Region: frr; PRK00083 573236002431 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 573236002432 hinge region; other site 573236002433 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 573236002434 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 573236002435 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 573236002436 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573236002437 FeS/SAM binding site; other site 573236002438 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573236002439 WHG domain; Region: WHG; pfam13305 573236002440 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 573236002441 Walker A/P-loop; other site 573236002442 ATP binding site [chemical binding]; other site 573236002443 ABC transporter; Region: ABC_tran; pfam00005 573236002444 Q-loop/lid; other site 573236002445 ABC transporter signature motif; other site 573236002446 Walker B; other site 573236002447 D-loop; other site 573236002448 H-loop/switch region; other site 573236002449 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 573236002450 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 573236002451 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 573236002452 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 573236002453 substrate binding site [chemical binding]; other site 573236002454 glutamase interaction surface [polypeptide binding]; other site 573236002455 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 573236002456 anthranilate synthase component I; Provisional; Region: PRK13571 573236002457 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 573236002458 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 573236002459 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 573236002460 putative uracil binding site [chemical binding]; other site 573236002461 putative active site [active] 573236002462 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 573236002463 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 573236002464 active site 573236002465 ribulose/triose binding site [chemical binding]; other site 573236002466 phosphate binding site [ion binding]; other site 573236002467 substrate (anthranilate) binding pocket [chemical binding]; other site 573236002468 product (indole) binding pocket [chemical binding]; other site 573236002469 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 573236002470 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236002471 catalytic residue [active] 573236002472 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 573236002473 substrate binding site [chemical binding]; other site 573236002474 active site 573236002475 catalytic residues [active] 573236002476 heterodimer interface [polypeptide binding]; other site 573236002477 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 573236002478 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 573236002479 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 573236002480 substrate binding site [chemical binding]; other site 573236002481 hexamer interface [polypeptide binding]; other site 573236002482 metal binding site [ion binding]; metal-binding site 573236002483 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 573236002484 homodimer interface [polypeptide binding]; other site 573236002485 putative metal binding site [ion binding]; other site 573236002486 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 573236002487 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 573236002488 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 573236002489 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 573236002490 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 573236002491 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 573236002492 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 573236002493 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 573236002494 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 573236002495 phosphopeptide binding site; other site 573236002496 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 573236002497 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573236002498 DNA binding residues [nucleotide binding] 573236002499 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 573236002500 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 573236002501 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 573236002502 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236002503 motif II; other site 573236002504 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 573236002505 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573236002506 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573236002507 ATP binding site [chemical binding]; other site 573236002508 putative Mg++ binding site [ion binding]; other site 573236002509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236002510 nucleotide binding region [chemical binding]; other site 573236002511 ATP-binding site [chemical binding]; other site 573236002512 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 573236002513 Predicted transcriptional regulator [Transcription]; Region: COG2378 573236002514 WYL domain; Region: WYL; pfam13280 573236002515 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573236002516 active site 573236002517 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 573236002518 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 573236002519 active site 573236002520 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 573236002521 CMP-binding site; other site 573236002522 The sites determining sugar specificity; other site 573236002523 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 573236002524 G1 box; other site 573236002525 GTP/Mg2+ binding site [chemical binding]; other site 573236002526 Switch I region; other site 573236002527 G2 box; other site 573236002528 Switch II region; other site 573236002529 G3 box; other site 573236002530 G4 box; other site 573236002531 G5 box; other site 573236002532 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 573236002533 G1 box; other site 573236002534 GTP/Mg2+ binding site [chemical binding]; other site 573236002535 Switch I region; other site 573236002536 G2 box; other site 573236002537 G3 box; other site 573236002538 Switch II region; other site 573236002539 G4 box; other site 573236002540 G5 box; other site 573236002541 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 573236002542 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573236002543 RNA binding surface [nucleotide binding]; other site 573236002544 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 573236002545 active site 573236002546 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 573236002547 amphipathic channel; other site 573236002548 Asn-Pro-Ala signature motifs; other site 573236002549 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 573236002550 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 573236002551 purine monophosphate binding site [chemical binding]; other site 573236002552 dimer interface [polypeptide binding]; other site 573236002553 putative catalytic residues [active] 573236002554 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 573236002555 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 573236002556 CoA binding domain; Region: CoA_binding; pfam02629 573236002557 CoA-ligase; Region: Ligase_CoA; pfam00549 573236002558 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 573236002559 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 573236002560 CoA-ligase; Region: Ligase_CoA; pfam00549 573236002561 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573236002562 active site 573236002563 Preprotein translocase subunit; Region: YajC; pfam02699 573236002564 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 573236002565 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236002566 Walker A motif; other site 573236002567 ATP binding site [chemical binding]; other site 573236002568 Walker B motif; other site 573236002569 arginine finger; other site 573236002570 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 573236002571 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 573236002572 RuvA N terminal domain; Region: RuvA_N; pfam01330 573236002573 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 573236002574 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 573236002575 active site 573236002576 putative DNA-binding cleft [nucleotide binding]; other site 573236002577 dimer interface [polypeptide binding]; other site 573236002578 hypothetical protein; Validated; Region: PRK00110 573236002579 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573236002580 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573236002581 lipid A biosynthesis lauroyl acyltransferase; Provisional; Region: PRK07920 573236002582 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 573236002583 putative acyl-acceptor binding pocket; other site 573236002584 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 573236002585 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 573236002586 thiS-thiF/thiG interaction site; other site 573236002587 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 573236002588 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 573236002589 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 573236002590 active site 573236002591 dimer interface [polypeptide binding]; other site 573236002592 motif 1; other site 573236002593 motif 2; other site 573236002594 motif 3; other site 573236002595 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 573236002596 anticodon binding site; other site 573236002597 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573236002598 ABC transporter; Region: ABC_tran; pfam00005 573236002599 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 573236002600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573236002601 Coenzyme A binding pocket [chemical binding]; other site 573236002602 PAC2 family; Region: PAC2; pfam09754 573236002603 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 573236002604 Fructosamine kinase; Region: Fructosamin_kin; cl17579 573236002605 chaperone protein DnaJ; Provisional; Region: PRK14278 573236002606 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573236002607 HSP70 interaction site [polypeptide binding]; other site 573236002608 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 573236002609 Zn binding sites [ion binding]; other site 573236002610 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573236002611 dimer interface [polypeptide binding]; other site 573236002612 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 573236002613 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 573236002614 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 573236002615 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 573236002616 TPP-binding site [chemical binding]; other site 573236002617 dimer interface [polypeptide binding]; other site 573236002618 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 573236002619 PYR/PP interface [polypeptide binding]; other site 573236002620 dimer interface [polypeptide binding]; other site 573236002621 TPP binding site [chemical binding]; other site 573236002622 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 573236002623 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 573236002624 putative active site [active] 573236002625 transaldolase; Provisional; Region: PRK03903 573236002626 catalytic residue [active] 573236002627 hypothetical protein; Validated; Region: PRK07682 573236002628 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236002629 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236002630 homodimer interface [polypeptide binding]; other site 573236002631 catalytic residue [active] 573236002632 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 573236002633 AsnC family; Region: AsnC_trans_reg; pfam01037 573236002634 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 573236002635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573236002636 non-specific DNA binding site [nucleotide binding]; other site 573236002637 salt bridge; other site 573236002638 sequence-specific DNA binding site [nucleotide binding]; other site 573236002639 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236002640 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236002641 homodimer interface [polypeptide binding]; other site 573236002642 catalytic residue [active] 573236002643 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 573236002644 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236002645 active site 573236002646 motif I; other site 573236002647 motif II; other site 573236002648 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236002649 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 573236002650 triosephosphate isomerase; Provisional; Region: PRK14567 573236002651 substrate binding site [chemical binding]; other site 573236002652 dimer interface [polypeptide binding]; other site 573236002653 catalytic triad [active] 573236002654 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 573236002655 Phosphoglycerate kinase; Region: PGK; pfam00162 573236002656 substrate binding site [chemical binding]; other site 573236002657 hinge regions; other site 573236002658 ADP binding site [chemical binding]; other site 573236002659 catalytic site [active] 573236002660 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 573236002661 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 573236002662 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 573236002663 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 573236002664 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 573236002665 shikimate binding site; other site 573236002666 NAD(P) binding site [chemical binding]; other site 573236002667 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14666 573236002668 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 573236002669 GIY-YIG motif/motif A; other site 573236002670 active site 573236002671 catalytic site [active] 573236002672 putative DNA binding site [nucleotide binding]; other site 573236002673 metal binding site [ion binding]; metal-binding site 573236002674 UvrB/uvrC motif; Region: UVR; pfam02151 573236002675 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 573236002676 Helix-hairpin-helix motif; Region: HHH; pfam00633 573236002677 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 573236002678 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573236002679 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 573236002680 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 573236002681 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 573236002682 putative active site [active] 573236002683 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 573236002684 Predicted esterase [General function prediction only]; Region: COG0400 573236002685 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 573236002686 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236002687 Walker A/P-loop; other site 573236002688 ATP binding site [chemical binding]; other site 573236002689 Q-loop/lid; other site 573236002690 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573236002691 ABC transporter signature motif; other site 573236002692 Walker B; other site 573236002693 D-loop; other site 573236002694 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 573236002695 Cation efflux family; Region: Cation_efflux; pfam01545 573236002696 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 573236002697 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 573236002698 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 573236002699 active site 573236002700 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 573236002701 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 573236002702 putative substrate binding site [chemical binding]; other site 573236002703 putative ATP binding site [chemical binding]; other site 573236002704 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 573236002705 dimer interface [polypeptide binding]; other site 573236002706 peroxiredoxin; Region: AhpC; TIGR03137 573236002707 decamer (pentamer of dimers) interface [polypeptide binding]; other site 573236002708 catalytic triad [active] 573236002709 peroxidatic and resolving cysteines [active] 573236002710 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 573236002711 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573236002712 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573236002713 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573236002714 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573236002715 Transcriptional regulator [Transcription]; Region: LysR; COG0583 573236002716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 573236002717 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 573236002718 dimerization interface [polypeptide binding]; other site 573236002719 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 573236002720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236002721 motif II; other site 573236002722 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 573236002723 putative active site [active] 573236002724 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 573236002725 Predicted transcriptional regulators [Transcription]; Region: COG1733 573236002726 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 573236002727 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573236002728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573236002729 Coenzyme A binding pocket [chemical binding]; other site 573236002730 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573236002731 active site 573236002732 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 573236002733 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 573236002734 heterodimer interface [polypeptide binding]; other site 573236002735 active site 573236002736 FMN binding site [chemical binding]; other site 573236002737 homodimer interface [polypeptide binding]; other site 573236002738 substrate binding site [chemical binding]; other site 573236002739 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 573236002740 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 573236002741 FAD binding pocket [chemical binding]; other site 573236002742 FAD binding motif [chemical binding]; other site 573236002743 phosphate binding motif [ion binding]; other site 573236002744 beta-alpha-beta structure motif; other site 573236002745 NAD binding pocket [chemical binding]; other site 573236002746 Iron coordination center [ion binding]; other site 573236002747 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 573236002748 active site 573236002749 dimer interface [polypeptide binding]; other site 573236002750 dihydroorotase; Validated; Region: pyrC; PRK09357 573236002751 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 573236002752 active site 573236002753 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 573236002754 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 573236002755 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 573236002756 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 573236002757 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 573236002758 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 573236002759 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 573236002760 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 573236002761 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573236002762 metal binding triad; other site 573236002763 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 573236002764 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 573236002765 metal binding triad; other site 573236002766 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 573236002767 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 573236002768 FAD binding site [chemical binding]; other site 573236002769 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 573236002770 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 573236002771 THF binding site; other site 573236002772 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 573236002773 substrate binding site [chemical binding]; other site 573236002774 THF binding site; other site 573236002775 zinc-binding site [ion binding]; other site 573236002776 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236002777 catalytic core [active] 573236002778 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 573236002779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573236002780 S-adenosylmethionine binding site [chemical binding]; other site 573236002781 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 573236002782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236002783 Walker A/P-loop; other site 573236002784 ATP binding site [chemical binding]; other site 573236002785 Q-loop/lid; other site 573236002786 ABC transporter signature motif; other site 573236002787 Walker B; other site 573236002788 D-loop; other site 573236002789 H-loop/switch region; other site 573236002790 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 573236002791 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573236002792 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 573236002793 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 573236002794 catalytic triad [active] 573236002795 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 573236002796 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573236002797 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 573236002798 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 573236002799 active site 573236002800 dimer interface [polypeptide binding]; other site 573236002801 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 573236002802 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 573236002803 active site 573236002804 FMN binding site [chemical binding]; other site 573236002805 substrate binding site [chemical binding]; other site 573236002806 3Fe-4S cluster binding site [ion binding]; other site 573236002807 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 573236002808 domain interface; other site 573236002809 coproporphyrinogen III oxidase; Validated; Region: PRK05628 573236002810 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573236002811 FeS/SAM binding site; other site 573236002812 HemN C-terminal domain; Region: HemN_C; pfam06969 573236002813 GTP-binding protein LepA; Provisional; Region: PRK05433 573236002814 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 573236002815 G1 box; other site 573236002816 putative GEF interaction site [polypeptide binding]; other site 573236002817 GTP/Mg2+ binding site [chemical binding]; other site 573236002818 Switch I region; other site 573236002819 G2 box; other site 573236002820 G3 box; other site 573236002821 Switch II region; other site 573236002822 G4 box; other site 573236002823 G5 box; other site 573236002824 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 573236002825 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 573236002826 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 573236002827 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 573236002828 UPF0126 domain; Region: UPF0126; pfam03458 573236002829 Predicted membrane protein [Function unknown]; Region: COG2860 573236002830 UPF0126 domain; Region: UPF0126; pfam03458 573236002831 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 573236002832 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 573236002833 homodimer interface [polypeptide binding]; other site 573236002834 substrate-cofactor binding pocket; other site 573236002835 catalytic residue [active] 573236002836 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 573236002837 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 573236002838 5S rRNA interface [nucleotide binding]; other site 573236002839 CTC domain interface [polypeptide binding]; other site 573236002840 L16 interface [polypeptide binding]; other site 573236002841 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573236002842 Serine hydrolase (FSH1); Region: FSH1; pfam03959 573236002843 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 573236002844 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 573236002845 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 573236002846 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 573236002847 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 573236002848 ligand binding site [chemical binding]; other site 573236002849 homodimer interface [polypeptide binding]; other site 573236002850 NAD(P) binding site [chemical binding]; other site 573236002851 trimer interface B [polypeptide binding]; other site 573236002852 trimer interface A [polypeptide binding]; other site 573236002853 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573236002854 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573236002855 acyl-activating enzyme (AAE) consensus motif; other site 573236002856 putative AMP binding site [chemical binding]; other site 573236002857 putative active site [active] 573236002858 putative CoA binding site [chemical binding]; other site 573236002859 GTPase Era; Reviewed; Region: era; PRK00089 573236002860 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 573236002861 G1 box; other site 573236002862 GTP/Mg2+ binding site [chemical binding]; other site 573236002863 Switch I region; other site 573236002864 G2 box; other site 573236002865 Switch II region; other site 573236002866 G3 box; other site 573236002867 G4 box; other site 573236002868 G5 box; other site 573236002869 KH domain; Region: KH_2; pfam07650 573236002870 Domain of unknown function DUF21; Region: DUF21; pfam01595 573236002871 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 573236002872 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 573236002873 Transporter associated domain; Region: CorC_HlyC; smart01091 573236002874 metal-binding heat shock protein; Provisional; Region: PRK00016 573236002875 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 573236002876 PhoH-like protein; Region: PhoH; pfam02562 573236002877 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 573236002878 nucleotide binding site/active site [active] 573236002879 HIT family signature motif; other site 573236002880 catalytic residue [active] 573236002881 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 573236002882 RNA methyltransferase, RsmE family; Region: TIGR00046 573236002883 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 573236002884 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 573236002885 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573236002886 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 573236002887 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 573236002888 ligand binding site; other site 573236002889 oligomer interface; other site 573236002890 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 573236002891 dimer interface [polypeptide binding]; other site 573236002892 N-terminal domain interface [polypeptide binding]; other site 573236002893 sulfate 1 binding site; other site 573236002894 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 573236002895 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 573236002896 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 573236002897 trimerization site [polypeptide binding]; other site 573236002898 active site 573236002899 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 573236002900 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 573236002901 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 573236002902 catalytic residue [active] 573236002903 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 573236002904 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 573236002905 Walker A/P-loop; other site 573236002906 ATP binding site [chemical binding]; other site 573236002907 Q-loop/lid; other site 573236002908 ABC transporter signature motif; other site 573236002909 Walker B; other site 573236002910 D-loop; other site 573236002911 H-loop/switch region; other site 573236002912 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 573236002913 FeS assembly protein SufD; Region: sufD; TIGR01981 573236002914 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 573236002915 FeS assembly protein SufB; Region: sufB; TIGR01980 573236002916 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 573236002917 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 573236002918 CTP synthetase; Validated; Region: pyrG; PRK05380 573236002919 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 573236002920 active site 573236002921 UTP binding site [chemical binding]; other site 573236002922 Catalytic site [active] 573236002923 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 573236002924 active site 573236002925 putative oxyanion hole; other site 573236002926 catalytic triad [active] 573236002927 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 573236002928 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 573236002929 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 573236002930 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 573236002931 catalytic nucleophile [active] 573236002932 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 573236002933 GIY-YIG motif/motif A; other site 573236002934 putative active site [active] 573236002935 putative metal binding site [ion binding]; other site 573236002936 Dehydroquinase class II; Region: DHquinase_II; pfam01220 573236002937 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 573236002938 trimer interface [polypeptide binding]; other site 573236002939 active site 573236002940 dimer interface [polypeptide binding]; other site 573236002941 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 573236002942 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 573236002943 ADP binding site [chemical binding]; other site 573236002944 magnesium binding site [ion binding]; other site 573236002945 putative shikimate binding site; other site 573236002946 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 573236002947 active site 573236002948 dimer interface [polypeptide binding]; other site 573236002949 metal binding site [ion binding]; metal-binding site 573236002950 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 573236002951 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 573236002952 Tetramer interface [polypeptide binding]; other site 573236002953 active site 573236002954 FMN-binding site [chemical binding]; other site 573236002955 YceG-like family; Region: YceG; pfam02618 573236002956 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 573236002957 dimerization interface [polypeptide binding]; other site 573236002958 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 573236002959 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 573236002960 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 573236002961 motif 1; other site 573236002962 active site 573236002963 motif 2; other site 573236002964 motif 3; other site 573236002965 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 573236002966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236002967 catalytic core [active] 573236002968 Membrane protein of unknown function; Region: DUF360; pfam04020 573236002969 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 573236002970 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 573236002971 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 573236002972 RNA binding surface [nucleotide binding]; other site 573236002973 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573236002974 Part of AAA domain; Region: AAA_19; pfam13245 573236002975 Family description; Region: UvrD_C_2; pfam13538 573236002976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573236002977 active site 573236002978 xanthine permease; Region: pbuX; TIGR03173 573236002979 Protein of unknown function (DUF3737); Region: DUF3737; pfam12541 573236002980 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 573236002981 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236002982 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236002983 homodimer interface [polypeptide binding]; other site 573236002984 catalytic residue [active] 573236002985 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 573236002986 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 573236002987 active site 573236002988 Na/Ca binding site [ion binding]; other site 573236002989 catalytic site [active] 573236002990 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 573236002991 Peptidase C26; Region: Peptidase_C26; pfam07722 573236002992 catalytic triad [active] 573236002993 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 573236002994 putative deacylase active site [active] 573236002995 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 573236002996 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 573236002997 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 573236002998 Walker A/P-loop; other site 573236002999 ATP binding site [chemical binding]; other site 573236003000 Q-loop/lid; other site 573236003001 ABC transporter signature motif; other site 573236003002 Walker B; other site 573236003003 D-loop; other site 573236003004 H-loop/switch region; other site 573236003005 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573236003006 DNA-binding site [nucleotide binding]; DNA binding site 573236003007 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 573236003008 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573236003009 non-specific DNA binding site [nucleotide binding]; other site 573236003010 salt bridge; other site 573236003011 sequence-specific DNA binding site [nucleotide binding]; other site 573236003012 adenosine deaminase; Provisional; Region: PRK09358 573236003013 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 573236003014 active site 573236003015 Chorismate mutase type II; Region: CM_2; cl00693 573236003016 hypothetical protein; Provisional; Region: PRK06761 573236003017 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573236003018 Coenzyme A binding pocket [chemical binding]; other site 573236003019 AAA domain; Region: AAA_17; pfam13207 573236003020 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 573236003021 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 573236003022 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 573236003023 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 573236003024 G1 box; other site 573236003025 putative GEF interaction site [polypeptide binding]; other site 573236003026 GTP/Mg2+ binding site [chemical binding]; other site 573236003027 Switch I region; other site 573236003028 G2 box; other site 573236003029 G3 box; other site 573236003030 Switch II region; other site 573236003031 G4 box; other site 573236003032 G5 box; other site 573236003033 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 573236003034 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 573236003035 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 573236003036 Transposase domain (DUF772); Region: DUF772; pfam05598 573236003037 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 573236003038 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 573236003039 GMP synthase; Reviewed; Region: guaA; PRK00074 573236003040 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 573236003041 AMP/PPi binding site [chemical binding]; other site 573236003042 candidate oxyanion hole; other site 573236003043 catalytic triad [active] 573236003044 potential glutamine specificity residues [chemical binding]; other site 573236003045 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 573236003046 ATP Binding subdomain [chemical binding]; other site 573236003047 Ligand Binding sites [chemical binding]; other site 573236003048 Dimerization subdomain; other site 573236003049 putative phosphoketolase; Provisional; Region: PRK05261 573236003050 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 573236003051 TPP-binding site; other site 573236003052 XFP C-terminal domain; Region: XFP_C; pfam09363 573236003053 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 573236003054 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 573236003055 propionate/acetate kinase; Provisional; Region: PRK12379 573236003056 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 573236003057 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 573236003058 hinge; other site 573236003059 active site 573236003060 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 573236003061 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 573236003062 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 573236003063 active site 573236003064 catalytic site [active] 573236003065 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 573236003066 dimer interface [polypeptide binding]; other site 573236003067 ADP-ribose binding site [chemical binding]; other site 573236003068 active site 573236003069 nudix motif; other site 573236003070 metal binding site [ion binding]; metal-binding site 573236003071 Uncharacterized conserved protein [Function unknown]; Region: COG0327 573236003072 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 573236003073 DNA polymerase I; Provisional; Region: PRK05755 573236003074 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 573236003075 active site 573236003076 metal binding site 1 [ion binding]; metal-binding site 573236003077 putative 5' ssDNA interaction site; other site 573236003078 metal binding site 3; metal-binding site 573236003079 metal binding site 2 [ion binding]; metal-binding site 573236003080 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 573236003081 putative DNA binding site [nucleotide binding]; other site 573236003082 putative metal binding site [ion binding]; other site 573236003083 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573236003084 active site 573236003085 substrate binding site [chemical binding]; other site 573236003086 catalytic site [active] 573236003087 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 573236003088 active site 573236003089 DNA binding site [nucleotide binding] 573236003090 catalytic site [active] 573236003091 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 573236003092 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573236003093 active site 573236003094 phosphorylation site [posttranslational modification] 573236003095 intermolecular recognition site; other site 573236003096 dimerization interface [polypeptide binding]; other site 573236003097 ANTAR domain; Region: ANTAR; pfam03861 573236003098 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 573236003099 dimer interface [polypeptide binding]; other site 573236003100 ADP-ribose binding site [chemical binding]; other site 573236003101 active site 573236003102 nudix motif; other site 573236003103 metal binding site [ion binding]; metal-binding site 573236003104 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 573236003105 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 573236003106 active site 573236003107 domain interfaces; other site 573236003108 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 573236003109 excinuclease ABC subunit B; Provisional; Region: PRK05298 573236003110 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573236003111 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236003112 nucleotide binding region [chemical binding]; other site 573236003113 ATP-binding site [chemical binding]; other site 573236003114 Ultra-violet resistance protein B; Region: UvrB; pfam12344 573236003115 UvrB/uvrC motif; Region: UVR; pfam02151 573236003116 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 573236003117 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 573236003118 CoA-binding site [chemical binding]; other site 573236003119 ATP-binding [chemical binding]; other site 573236003120 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 573236003121 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 573236003122 RNA binding site [nucleotide binding]; other site 573236003123 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 573236003124 RNA binding site [nucleotide binding]; other site 573236003125 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 573236003126 RNA binding site [nucleotide binding]; other site 573236003127 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 573236003128 RNA binding site [nucleotide binding]; other site 573236003129 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 573236003130 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 573236003131 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 573236003132 homodimer interface [polypeptide binding]; other site 573236003133 NADP binding site [chemical binding]; other site 573236003134 substrate binding site [chemical binding]; other site 573236003135 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 573236003136 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 573236003137 intersubunit interface [polypeptide binding]; other site 573236003138 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 573236003139 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 573236003140 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 573236003141 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 573236003142 ABC-ATPase subunit interface; other site 573236003143 dimer interface [polypeptide binding]; other site 573236003144 putative PBP binding regions; other site 573236003145 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 573236003146 homotrimer interaction site [polypeptide binding]; other site 573236003147 zinc binding site [ion binding]; other site 573236003148 CDP-binding sites; other site 573236003149 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 573236003150 glycogen branching enzyme; Provisional; Region: PRK05402 573236003151 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 573236003152 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 573236003153 active site 573236003154 catalytic site [active] 573236003155 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 573236003156 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573236003157 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573236003158 active site 573236003159 phosphorylation site [posttranslational modification] 573236003160 intermolecular recognition site; other site 573236003161 dimerization interface [polypeptide binding]; other site 573236003162 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573236003163 DNA binding site [nucleotide binding] 573236003164 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 573236003165 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 573236003166 dimerization interface [polypeptide binding]; other site 573236003167 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 573236003168 dimer interface [polypeptide binding]; other site 573236003169 phosphorylation site [posttranslational modification] 573236003170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573236003171 ATP binding site [chemical binding]; other site 573236003172 Mg2+ binding site [ion binding]; other site 573236003173 G-X-G motif; other site 573236003174 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 573236003175 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573236003176 active site 573236003177 Eukaryotic phosphomannomutase; Region: PMM; cl17107 573236003178 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 573236003179 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 573236003180 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 573236003181 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 573236003182 Transcriptional regulator [Transcription]; Region: LytR; COG1316 573236003183 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 573236003184 Transcription factor WhiB; Region: Whib; pfam02467 573236003185 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 573236003186 PAS fold; Region: PAS_4; pfam08448 573236003187 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 573236003188 Histidine kinase; Region: HisKA_2; pfam07568 573236003189 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573236003190 ATP binding site [chemical binding]; other site 573236003191 Mg2+ binding site [ion binding]; other site 573236003192 G-X-G motif; other site 573236003193 V-type ATP synthase subunit E; Provisional; Region: PRK01558 573236003194 Haemolysin-III related; Region: HlyIII; pfam03006 573236003195 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 573236003196 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 573236003197 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 573236003198 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573236003199 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 573236003200 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 573236003201 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 573236003202 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 573236003203 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 573236003204 Protein of unknown function (DUF501); Region: DUF501; pfam04417 573236003205 Septum formation initiator; Region: DivIC; pfam04977 573236003206 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 573236003207 enolase; Provisional; Region: eno; PRK00077 573236003208 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 573236003209 dimer interface [polypeptide binding]; other site 573236003210 metal binding site [ion binding]; metal-binding site 573236003211 substrate binding pocket [chemical binding]; other site 573236003212 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573236003213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236003214 dimer interface [polypeptide binding]; other site 573236003215 conserved gate region; other site 573236003216 putative PBP binding loops; other site 573236003217 ABC-ATPase subunit interface; other site 573236003218 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 573236003219 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 573236003220 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 573236003221 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 573236003222 Walker A/P-loop; other site 573236003223 ATP binding site [chemical binding]; other site 573236003224 Q-loop/lid; other site 573236003225 ABC transporter signature motif; other site 573236003226 Walker B; other site 573236003227 D-loop; other site 573236003228 H-loop/switch region; other site 573236003229 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 573236003230 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 573236003231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573236003232 ATP binding site [chemical binding]; other site 573236003233 putative Mg++ binding site [ion binding]; other site 573236003234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236003235 nucleotide binding region [chemical binding]; other site 573236003236 ATP-binding site [chemical binding]; other site 573236003237 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 573236003238 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 573236003239 putative active site [active] 573236003240 catalytic residue [active] 573236003241 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 573236003242 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573236003243 Coenzyme A binding pocket [chemical binding]; other site 573236003244 Uncharacterized conserved protein [Function unknown]; Region: COG1615 573236003245 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 573236003246 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 573236003247 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 573236003248 Protein of unknown function (DUF466); Region: DUF466; cl01082 573236003249 carbon starvation protein A; Provisional; Region: PRK15015 573236003250 Carbon starvation protein CstA; Region: CstA; pfam02554 573236003251 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 573236003252 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236003253 H-loop/switch region; other site 573236003254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236003255 ABC transporter signature motif; other site 573236003256 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 573236003257 Q-loop/lid; other site 573236003258 ABC transporter signature motif; other site 573236003259 Walker B; other site 573236003260 D-loop; other site 573236003261 H-loop/switch region; other site 573236003262 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 573236003263 MarR family; Region: MarR_2; pfam12802 573236003264 Ubinuclein conserved middle domain; Region: UBN_AB; pfam14075 573236003265 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 573236003266 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 573236003267 Aspartase; Region: Aspartase; cd01357 573236003268 active sites [active] 573236003269 tetramer interface [polypeptide binding]; other site 573236003270 FeoA domain; Region: FeoA; pfam04023 573236003271 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 573236003272 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 573236003273 G1 box; other site 573236003274 GTP/Mg2+ binding site [chemical binding]; other site 573236003275 Switch I region; other site 573236003276 G2 box; other site 573236003277 G3 box; other site 573236003278 Switch II region; other site 573236003279 G4 box; other site 573236003280 G5 box; other site 573236003281 Nucleoside recognition; Region: Gate; pfam07670 573236003282 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 573236003283 Nucleoside recognition; Region: Gate; pfam07670 573236003284 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 573236003285 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 573236003286 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 573236003287 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 573236003288 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 573236003289 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 573236003290 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 573236003291 putative active site [active] 573236003292 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 573236003293 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 573236003294 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 573236003295 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 573236003296 catalytic triad [active] 573236003297 active site nucleophile [active] 573236003298 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 573236003299 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 573236003300 SelR domain; Region: SelR; pfam01641 573236003301 methionine sulfoxide reductase B; Provisional; Region: PRK00222 573236003302 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 573236003303 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573236003304 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573236003305 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573236003306 Uncharacterized conserved protein [Function unknown]; Region: COG3350 573236003307 classical (c) SDRs; Region: SDR_c; cd05233 573236003308 NAD(P) binding site [chemical binding]; other site 573236003309 active site 573236003310 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 573236003311 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 573236003312 ATP binding site [chemical binding]; other site 573236003313 Mg++ binding site [ion binding]; other site 573236003314 motif III; other site 573236003315 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236003316 nucleotide binding region [chemical binding]; other site 573236003317 ATP-binding site [chemical binding]; other site 573236003318 Predicted membrane protein [Function unknown]; Region: COG2855 573236003319 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 573236003320 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 573236003321 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 573236003322 substrate binding pocket [chemical binding]; other site 573236003323 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 573236003324 GTP-binding protein YchF; Reviewed; Region: PRK09601 573236003325 YchF GTPase; Region: YchF; cd01900 573236003326 G1 box; other site 573236003327 GTP/Mg2+ binding site [chemical binding]; other site 573236003328 Switch I region; other site 573236003329 G2 box; other site 573236003330 Switch II region; other site 573236003331 G3 box; other site 573236003332 G4 box; other site 573236003333 G5 box; other site 573236003334 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 573236003335 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 573236003336 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 573236003337 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 573236003338 Histidine kinase; Region: HisKA_3; pfam07730 573236003339 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573236003340 ATP binding site [chemical binding]; other site 573236003341 Mg2+ binding site [ion binding]; other site 573236003342 G-X-G motif; other site 573236003343 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573236003344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573236003345 active site 573236003346 phosphorylation site [posttranslational modification] 573236003347 intermolecular recognition site; other site 573236003348 dimerization interface [polypeptide binding]; other site 573236003349 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573236003350 DNA binding residues [nucleotide binding] 573236003351 dimerization interface [polypeptide binding]; other site 573236003352 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573236003353 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 573236003354 FtsX-like permease family; Region: FtsX; pfam02687 573236003355 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573236003356 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573236003357 Walker A/P-loop; other site 573236003358 ATP binding site [chemical binding]; other site 573236003359 Q-loop/lid; other site 573236003360 ABC transporter signature motif; other site 573236003361 Walker B; other site 573236003362 D-loop; other site 573236003363 H-loop/switch region; other site 573236003364 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 573236003365 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 573236003366 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573236003367 Walker A/P-loop; other site 573236003368 ATP binding site [chemical binding]; other site 573236003369 Q-loop/lid; other site 573236003370 ABC transporter signature motif; other site 573236003371 Walker B; other site 573236003372 D-loop; other site 573236003373 H-loop/switch region; other site 573236003374 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 573236003375 Walker A/P-loop; other site 573236003376 ATP binding site [chemical binding]; other site 573236003377 Q-loop/lid; other site 573236003378 ABC transporter signature motif; other site 573236003379 Walker B; other site 573236003380 D-loop; other site 573236003381 H-loop/switch region; other site 573236003382 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 573236003383 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 573236003384 homodimer interface [polypeptide binding]; other site 573236003385 substrate-cofactor binding pocket; other site 573236003386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236003387 catalytic residue [active] 573236003388 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 573236003389 dimer interface [polypeptide binding]; other site 573236003390 pyridoxal binding site [chemical binding]; other site 573236003391 ATP binding site [chemical binding]; other site 573236003392 hypothetical protein; Provisional; Region: PRK14681 573236003393 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 573236003394 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 573236003395 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236003396 Walker A motif; other site 573236003397 ATP binding site [chemical binding]; other site 573236003398 Walker B motif; other site 573236003399 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 573236003400 DNA protecting protein DprA; Region: dprA; TIGR00732 573236003401 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 573236003402 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 573236003403 L-aspartate oxidase; Provisional; Region: PRK06175 573236003404 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 573236003405 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 573236003406 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 573236003407 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 573236003408 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573236003409 S-adenosylmethionine binding site [chemical binding]; other site 573236003410 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 573236003411 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 573236003412 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 573236003413 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236003414 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236003415 homodimer interface [polypeptide binding]; other site 573236003416 catalytic residue [active] 573236003417 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 573236003418 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 573236003419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236003420 Walker A motif; other site 573236003421 ATP binding site [chemical binding]; other site 573236003422 Walker B motif; other site 573236003423 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 573236003424 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 573236003425 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 573236003426 oligomer interface [polypeptide binding]; other site 573236003427 active site residues [active] 573236003428 Clp protease; Region: CLP_protease; pfam00574 573236003429 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 573236003430 oligomer interface [polypeptide binding]; other site 573236003431 active site residues [active] 573236003432 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 573236003433 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 573236003434 putative ion selectivity filter; other site 573236003435 putative pore gating glutamate residue; other site 573236003436 trigger factor; Provisional; Region: tig; PRK01490 573236003437 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573236003438 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 573236003439 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 573236003440 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573236003441 active site 573236003442 catalytic site [active] 573236003443 substrate binding site [chemical binding]; other site 573236003444 HRDC domain; Region: HRDC; pfam00570 573236003445 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 573236003446 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573236003447 FeS/SAM binding site; other site 573236003448 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 573236003449 Pyruvate formate lyase 1; Region: PFL1; cd01678 573236003450 coenzyme A binding site [chemical binding]; other site 573236003451 active site 573236003452 catalytic residues [active] 573236003453 glycine loop; other site 573236003454 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 573236003455 NAD synthetase; Provisional; Region: PRK13981 573236003456 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 573236003457 multimer interface [polypeptide binding]; other site 573236003458 active site 573236003459 catalytic triad [active] 573236003460 protein interface 1 [polypeptide binding]; other site 573236003461 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 573236003462 homodimer interface [polypeptide binding]; other site 573236003463 NAD binding pocket [chemical binding]; other site 573236003464 ATP binding pocket [chemical binding]; other site 573236003465 Mg binding site [ion binding]; other site 573236003466 active-site loop [active] 573236003467 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 573236003468 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 573236003469 metal binding site [ion binding]; metal-binding site 573236003470 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236003471 conserved gate region; other site 573236003472 ABC-ATPase subunit interface; other site 573236003473 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 573236003474 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 573236003475 Walker A/P-loop; other site 573236003476 ATP binding site [chemical binding]; other site 573236003477 Q-loop/lid; other site 573236003478 ABC transporter signature motif; other site 573236003479 Walker B; other site 573236003480 D-loop; other site 573236003481 H-loop/switch region; other site 573236003482 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 573236003483 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 573236003484 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 573236003485 active site 573236003486 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 573236003487 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573236003488 Zn2+ binding site [ion binding]; other site 573236003489 Mg2+ binding site [ion binding]; other site 573236003490 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573236003491 synthetase active site [active] 573236003492 NTP binding site [chemical binding]; other site 573236003493 metal binding site [ion binding]; metal-binding site 573236003494 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 573236003495 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 573236003496 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573236003497 trimer interface [polypeptide binding]; other site 573236003498 active site 573236003499 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 573236003500 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 573236003501 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 573236003502 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 573236003503 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 573236003504 CAP-like domain; other site 573236003505 active site 573236003506 primary dimer interface [polypeptide binding]; other site 573236003507 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 573236003508 EamA-like transporter family; Region: EamA; cl17759 573236003509 DEAD-like helicases superfamily; Region: DEXDc; smart00487 573236003510 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573236003511 ATP binding site [chemical binding]; other site 573236003512 putative Mg++ binding site [ion binding]; other site 573236003513 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 573236003514 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236003515 nucleotide binding region [chemical binding]; other site 573236003516 ATP-binding site [chemical binding]; other site 573236003517 DEAD/H associated; Region: DEAD_assoc; pfam08494 573236003518 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236003519 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236003520 putative substrate translocation pore; other site 573236003521 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 573236003522 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 573236003523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 573236003524 ATP binding site [chemical binding]; other site 573236003525 Mg2+ binding site [ion binding]; other site 573236003526 G-X-G motif; other site 573236003527 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 573236003528 anchoring element; other site 573236003529 dimer interface [polypeptide binding]; other site 573236003530 ATP binding site [chemical binding]; other site 573236003531 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 573236003532 active site 573236003533 putative metal-binding site [ion binding]; other site 573236003534 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 573236003535 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 573236003536 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 573236003537 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573236003538 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 573236003539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573236003540 DNA binding residues [nucleotide binding] 573236003541 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 573236003542 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 573236003543 substrate binding pocket [chemical binding]; other site 573236003544 chain length determination region; other site 573236003545 substrate-Mg2+ binding site; other site 573236003546 catalytic residues [active] 573236003547 aspartate-rich region 1; other site 573236003548 active site lid residues [active] 573236003549 aspartate-rich region 2; other site 573236003550 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573236003551 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573236003552 active site 573236003553 ATP binding site [chemical binding]; other site 573236003554 substrate binding site [chemical binding]; other site 573236003555 activation loop (A-loop); other site 573236003556 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573236003557 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573236003558 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 573236003559 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 573236003560 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 573236003561 putative acyl-acceptor binding pocket; other site 573236003562 TrbC/VIRB2 family; Region: TrbC; pfam04956 573236003563 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 573236003564 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 573236003565 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 573236003566 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 573236003567 DEAD/DEAH box helicase; Region: DEAD; pfam00270 573236003568 ATP binding site [chemical binding]; other site 573236003569 putative Mg++ binding site [ion binding]; other site 573236003570 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 573236003571 SEC-C motif; Region: SEC-C; pfam02810 573236003572 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 573236003573 30S subunit binding site; other site 573236003574 RecX family; Region: RecX; pfam02631 573236003575 recombinase A; Provisional; Region: recA; PRK09354 573236003576 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 573236003577 hexamer interface [polypeptide binding]; other site 573236003578 Walker A motif; other site 573236003579 ATP binding site [chemical binding]; other site 573236003580 Walker B motif; other site 573236003581 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 573236003582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 573236003583 non-specific DNA binding site [nucleotide binding]; other site 573236003584 salt bridge; other site 573236003585 sequence-specific DNA binding site [nucleotide binding]; other site 573236003586 Competence-damaged protein; Region: CinA; pfam02464 573236003587 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 573236003588 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 573236003589 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 573236003590 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 573236003591 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 573236003592 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 573236003593 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 573236003594 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 573236003595 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573236003596 FeS/SAM binding site; other site 573236003597 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 573236003598 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 573236003599 synthetase active site [active] 573236003600 NTP binding site [chemical binding]; other site 573236003601 metal binding site [ion binding]; metal-binding site 573236003602 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 573236003603 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 573236003604 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 573236003605 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 573236003606 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 573236003607 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 573236003608 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 573236003609 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236003610 Walker A/P-loop; other site 573236003611 ATP binding site [chemical binding]; other site 573236003612 Q-loop/lid; other site 573236003613 ABC transporter signature motif; other site 573236003614 Walker B; other site 573236003615 D-loop; other site 573236003616 H-loop/switch region; other site 573236003617 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573236003618 Histidine kinase; Region: HisKA_3; pfam07730 573236003619 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573236003620 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573236003621 active site 573236003622 phosphorylation site [posttranslational modification] 573236003623 intermolecular recognition site; other site 573236003624 dimerization interface [polypeptide binding]; other site 573236003625 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573236003626 DNA binding residues [nucleotide binding] 573236003627 dimerization interface [polypeptide binding]; other site 573236003628 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 573236003629 Transposase; Region: DDE_Tnp_ISL3; pfam01610 573236003630 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 573236003631 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 573236003632 active site 573236003633 catalytic site [active] 573236003634 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 573236003635 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573236003636 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573236003637 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 573236003638 Transposase; Region: DDE_Tnp_ISL3; pfam01610 573236003639 Protein of unknown function DUF262; Region: DUF262; pfam03235 573236003640 Uncharacterized conserved protein [Function unknown]; Region: COG1479 573236003641 Protein of unknown function DUF262; Region: DUF262; pfam03235 573236003642 maltose O-acetyltransferase; Provisional; Region: PRK10092 573236003643 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 573236003644 active site 573236003645 substrate binding site [chemical binding]; other site 573236003646 trimer interface [polypeptide binding]; other site 573236003647 CoA binding site [chemical binding]; other site 573236003648 aconitate hydratase; Validated; Region: PRK09277 573236003649 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 573236003650 substrate binding site [chemical binding]; other site 573236003651 ligand binding site [chemical binding]; other site 573236003652 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 573236003653 substrate binding site [chemical binding]; other site 573236003654 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 573236003655 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573236003656 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573236003657 Soluble P-type ATPase [General function prediction only]; Region: COG4087 573236003658 Protein of unknown function (DUF418); Region: DUF418; cl12135 573236003659 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 573236003660 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 573236003661 TRAM domain; Region: TRAM; cl01282 573236003662 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 573236003663 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 573236003664 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 573236003665 putative active site [active] 573236003666 putative catalytic site [active] 573236003667 putative DNA binding site [nucleotide binding]; other site 573236003668 putative phosphate binding site [ion binding]; other site 573236003669 metal binding site A [ion binding]; metal-binding site 573236003670 putative AP binding site [nucleotide binding]; other site 573236003671 putative metal binding site B [ion binding]; other site 573236003672 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573236003673 AAA domain; Region: AAA_21; pfam13304 573236003674 Walker A/P-loop; other site 573236003675 ATP binding site [chemical binding]; other site 573236003676 Q-loop/lid; other site 573236003677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573236003678 ABC transporter signature motif; other site 573236003679 Walker B; other site 573236003680 D-loop; other site 573236003681 H-loop/switch region; other site 573236003682 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573236003683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573236003684 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 573236003685 Walker A/P-loop; other site 573236003686 ATP binding site [chemical binding]; other site 573236003687 Q-loop/lid; other site 573236003688 ABC transporter signature motif; other site 573236003689 Walker B; other site 573236003690 D-loop; other site 573236003691 H-loop/switch region; other site 573236003692 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 573236003693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236003694 dimer interface [polypeptide binding]; other site 573236003695 conserved gate region; other site 573236003696 putative PBP binding loops; other site 573236003697 ABC-ATPase subunit interface; other site 573236003698 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573236003699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236003700 dimer interface [polypeptide binding]; other site 573236003701 conserved gate region; other site 573236003702 putative PBP binding loops; other site 573236003703 ABC-ATPase subunit interface; other site 573236003704 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 573236003705 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 573236003706 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 573236003707 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573236003708 active site 573236003709 DNA binding site [nucleotide binding] 573236003710 Int/Topo IB signature motif; other site 573236003711 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573236003712 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 573236003713 Walker A/P-loop; other site 573236003714 ATP binding site [chemical binding]; other site 573236003715 Q-loop/lid; other site 573236003716 ABC transporter signature motif; other site 573236003717 Walker B; other site 573236003718 D-loop; other site 573236003719 H-loop/switch region; other site 573236003720 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 573236003721 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573236003722 FtsX-like permease family; Region: FtsX; pfam02687 573236003723 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573236003724 FtsX-like permease family; Region: FtsX; pfam02687 573236003725 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 573236003726 prephenate dehydrogenase; Validated; Region: PRK08507 573236003727 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 573236003728 Prephenate dehydratase; Region: PDT; pfam00800 573236003729 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 573236003730 putative L-Phe binding site [chemical binding]; other site 573236003731 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 573236003732 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 573236003733 G1 box; other site 573236003734 putative GEF interaction site [polypeptide binding]; other site 573236003735 GTP/Mg2+ binding site [chemical binding]; other site 573236003736 Switch I region; other site 573236003737 G2 box; other site 573236003738 G3 box; other site 573236003739 Switch II region; other site 573236003740 G4 box; other site 573236003741 G5 box; other site 573236003742 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 573236003743 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 573236003744 benzoate transport; Region: 2A0115; TIGR00895 573236003745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236003746 putative substrate translocation pore; other site 573236003747 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 573236003748 nudix motif; other site 573236003749 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 573236003750 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573236003751 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573236003752 P-loop; other site 573236003753 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 573236003754 Magnesium ion binding site [ion binding]; other site 573236003755 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573236003756 Magnesium ion binding site [ion binding]; other site 573236003757 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 573236003758 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 573236003759 active site 573236003760 Int/Topo IB signature motif; other site 573236003761 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 573236003762 23S rRNA binding site [nucleotide binding]; other site 573236003763 L21 binding site [polypeptide binding]; other site 573236003764 L13 binding site [polypeptide binding]; other site 573236003765 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 573236003766 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 573236003767 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 573236003768 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 573236003769 Thiamine pyrophosphokinase; Region: TPK; cd07995 573236003770 active site 573236003771 dimerization interface [polypeptide binding]; other site 573236003772 thiamine binding site [chemical binding]; other site 573236003773 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 573236003774 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 573236003775 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 573236003776 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 573236003777 putative deacylase active site [active] 573236003778 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 573236003779 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 573236003780 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 573236003781 active site 573236003782 catalytic residues [active] 573236003783 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 573236003784 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 573236003785 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 573236003786 DNA binding residues [nucleotide binding] 573236003787 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 573236003788 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573236003789 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573236003790 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573236003791 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 573236003792 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 573236003793 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 573236003794 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573236003795 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573236003796 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 573236003797 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 573236003798 active site 573236003799 phosphorylation site [posttranslational modification] 573236003800 intermolecular recognition site; other site 573236003801 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 573236003802 DNA binding residues [nucleotide binding] 573236003803 dimerization interface [polypeptide binding]; other site 573236003804 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 573236003805 Histidine kinase; Region: HisKA_3; pfam07730 573236003806 proline aminopeptidase P II; Provisional; Region: PRK10879 573236003807 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 573236003808 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 573236003809 active site 573236003810 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 573236003811 nudix motif; other site 573236003812 MarR family; Region: MarR_2; cl17246 573236003813 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573236003814 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 573236003815 nucleotide binding site [chemical binding]; other site 573236003816 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573236003817 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 573236003818 putative substrate binding site [chemical binding]; other site 573236003819 putative ATP binding site [chemical binding]; other site 573236003820 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 573236003821 putative active site [active] 573236003822 dimerization interface [polypeptide binding]; other site 573236003823 putative tRNAtyr binding site [nucleotide binding]; other site 573236003824 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573236003825 active site 573236003826 DNA binding site [nucleotide binding] 573236003827 Int/Topo IB signature motif; other site 573236003828 Helix-turn-helix domain; Region: HTH_17; pfam12728 573236003829 Helix-turn-helix domain; Region: HTH_17; pfam12728 573236003830 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573236003831 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 573236003832 Walker A motif; other site 573236003833 ATP binding site [chemical binding]; other site 573236003834 Walker B motif; other site 573236003835 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 573236003836 Phage capsid family; Region: Phage_capsid; pfam05065 573236003837 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 573236003838 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573236003839 Walker A/P-loop; other site 573236003840 ATP binding site [chemical binding]; other site 573236003841 Q-loop/lid; other site 573236003842 ABC transporter signature motif; other site 573236003843 Walker B; other site 573236003844 D-loop; other site 573236003845 H-loop/switch region; other site 573236003846 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573236003847 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 573236003848 Walker A/P-loop; other site 573236003849 ATP binding site [chemical binding]; other site 573236003850 Q-loop/lid; other site 573236003851 ABC transporter signature motif; other site 573236003852 Walker B; other site 573236003853 D-loop; other site 573236003854 H-loop/switch region; other site 573236003855 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573236003856 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 573236003857 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 573236003858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236003859 dimer interface [polypeptide binding]; other site 573236003860 conserved gate region; other site 573236003861 ABC-ATPase subunit interface; other site 573236003862 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 573236003863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236003864 dimer interface [polypeptide binding]; other site 573236003865 conserved gate region; other site 573236003866 putative PBP binding loops; other site 573236003867 ABC-ATPase subunit interface; other site 573236003868 cell division protein FtsQ; Provisional; Region: PRK05529 573236003869 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 573236003870 Cell division protein FtsQ; Region: FtsQ; pfam03799 573236003871 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 573236003872 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573236003873 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573236003874 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573236003875 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 573236003876 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 573236003877 active site 573236003878 homodimer interface [polypeptide binding]; other site 573236003879 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 573236003880 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 573236003881 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 573236003882 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573236003883 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573236003884 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 573236003885 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 573236003886 Mg++ binding site [ion binding]; other site 573236003887 putative catalytic motif [active] 573236003888 putative substrate binding site [chemical binding]; other site 573236003889 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 573236003890 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 573236003891 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 573236003892 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 573236003893 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 573236003894 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 573236003895 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 573236003896 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 573236003897 MraW methylase family; Region: Methyltransf_5; cl17771 573236003898 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 573236003899 MraZ protein; Region: MraZ; pfam02381 573236003900 cell division protein MraZ; Reviewed; Region: PRK00326 573236003901 MraZ protein; Region: MraZ; pfam02381 573236003902 Part of AAA domain; Region: AAA_19; pfam13245 573236003903 Family description; Region: UvrD_C_2; pfam13538 573236003904 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 573236003905 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 573236003906 ligand binding site [chemical binding]; other site 573236003907 NAD binding site [chemical binding]; other site 573236003908 tetramer interface [polypeptide binding]; other site 573236003909 catalytic site [active] 573236003910 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 573236003911 L-serine binding site [chemical binding]; other site 573236003912 ACT domain interface; other site 573236003913 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 573236003914 ATP cone domain; Region: ATP-cone; pfam03477 573236003915 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 573236003916 LexA repressor; Validated; Region: PRK00215 573236003917 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 573236003918 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 573236003919 Catalytic site [active] 573236003920 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 573236003921 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 573236003922 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 573236003923 NAD binding site [chemical binding]; other site 573236003924 dimer interface [polypeptide binding]; other site 573236003925 substrate binding site [chemical binding]; other site 573236003926 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573236003927 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 573236003928 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 573236003929 HflX GTPase family; Region: HflX; cd01878 573236003930 G1 box; other site 573236003931 GTP/Mg2+ binding site [chemical binding]; other site 573236003932 Switch I region; other site 573236003933 G2 box; other site 573236003934 G3 box; other site 573236003935 Switch II region; other site 573236003936 G4 box; other site 573236003937 G5 box; other site 573236003938 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 573236003939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 573236003940 S-adenosylmethionine binding site [chemical binding]; other site 573236003941 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 573236003942 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 573236003943 ATP binding site [chemical binding]; other site 573236003944 putative Mg++ binding site [ion binding]; other site 573236003945 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 573236003946 nucleotide binding region [chemical binding]; other site 573236003947 ATP-binding site [chemical binding]; other site 573236003948 Helicase associated domain (HA2); Region: HA2; pfam04408 573236003949 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 573236003950 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 573236003951 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 573236003952 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 573236003953 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 573236003954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 573236003955 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 573236003956 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 573236003957 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 573236003958 catalytic residues [active] 573236003959 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 573236003960 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 573236003961 putative active site [active] 573236003962 oxyanion strand; other site 573236003963 catalytic triad [active] 573236003964 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 573236003965 putative active site pocket [active] 573236003966 4-fold oligomerization interface [polypeptide binding]; other site 573236003967 metal binding residues [ion binding]; metal-binding site 573236003968 3-fold/trimer interface [polypeptide binding]; other site 573236003969 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 573236003970 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236003971 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236003972 homodimer interface [polypeptide binding]; other site 573236003973 catalytic residue [active] 573236003974 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 573236003975 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 573236003976 NAD binding site [chemical binding]; other site 573236003977 dimerization interface [polypeptide binding]; other site 573236003978 product binding site; other site 573236003979 substrate binding site [chemical binding]; other site 573236003980 zinc binding site [ion binding]; other site 573236003981 catalytic residues [active] 573236003982 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 573236003983 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 573236003984 active site 573236003985 PHP Thumb interface [polypeptide binding]; other site 573236003986 metal binding site [ion binding]; metal-binding site 573236003987 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 573236003988 generic binding surface I; other site 573236003989 generic binding surface II; other site 573236003990 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 573236003991 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 573236003992 RNA binding surface [nucleotide binding]; other site 573236003993 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 573236003994 active site 573236003995 lipoprotein signal peptidase; Provisional; Region: PRK14771 573236003996 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 573236003997 YGGT family; Region: YGGT; pfam02325 573236003998 Protein of unknown function (DUF552); Region: DUF552; pfam04472 573236003999 cell division protein FtsZ; Validated; Region: PRK09330 573236004000 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 573236004001 nucleotide binding site [chemical binding]; other site 573236004002 SulA interaction site; other site 573236004003 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 573236004004 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 573236004005 FMN binding site [chemical binding]; other site 573236004006 active site 573236004007 catalytic residues [active] 573236004008 substrate binding site [chemical binding]; other site 573236004009 glycyl-tRNA synthetase; Provisional; Region: PRK04173 573236004010 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 573236004011 motif 1; other site 573236004012 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 573236004013 active site 573236004014 motif 2; other site 573236004015 motif 3; other site 573236004016 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 573236004017 anticodon binding site; other site 573236004018 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 573236004019 substrate binding site [chemical binding]; other site 573236004020 multimerization interface [polypeptide binding]; other site 573236004021 ATP binding site [chemical binding]; other site 573236004022 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 573236004023 thiamine phosphate binding site [chemical binding]; other site 573236004024 active site 573236004025 pyrophosphate binding site [ion binding]; other site 573236004026 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 573236004027 substrate binding site [chemical binding]; other site 573236004028 dimer interface [polypeptide binding]; other site 573236004029 ATP binding site [chemical binding]; other site 573236004030 Domain of unknown function DUF77; Region: DUF77; pfam01910 573236004031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236004032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236004033 DNA binding site [nucleotide binding] 573236004034 domain linker motif; other site 573236004035 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 573236004036 putative dimerization interface [polypeptide binding]; other site 573236004037 putative ligand binding site [chemical binding]; other site 573236004038 galactoside permease; Reviewed; Region: lacY; PRK09528 573236004039 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236004040 putative substrate translocation pore; other site 573236004041 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 573236004042 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 573236004043 substrate binding [chemical binding]; other site 573236004044 active site 573236004045 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 573236004046 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 573236004047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236004048 dimer interface [polypeptide binding]; other site 573236004049 conserved gate region; other site 573236004050 putative PBP binding loops; other site 573236004051 ABC-ATPase subunit interface; other site 573236004052 NMT1/THI5 like; Region: NMT1; pfam09084 573236004053 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 573236004054 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 573236004055 active site 573236004056 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 573236004057 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 573236004058 catalytic residue [active] 573236004059 putative FPP diphosphate binding site; other site 573236004060 putative FPP binding hydrophobic cleft; other site 573236004061 dimer interface [polypeptide binding]; other site 573236004062 putative IPP diphosphate binding site; other site 573236004063 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 573236004064 Recombination protein O N terminal; Region: RecO_N; pfam11967 573236004065 Recombination protein O C terminal; Region: RecO_C; pfam02565 573236004066 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573236004067 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 573236004068 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573236004069 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 573236004070 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 573236004071 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 573236004072 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 573236004073 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 573236004074 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 573236004075 DivIVA domain; Region: DivI1A_domain; TIGR03544 573236004076 DivIVA domain; Region: DivI1A_domain; TIGR03544 573236004077 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 573236004078 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 573236004079 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 573236004080 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 573236004081 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 573236004082 Part of AAA domain; Region: AAA_19; pfam13245 573236004083 Family description; Region: UvrD_C_2; pfam13538 573236004084 Phosphotransferase enzyme family; Region: APH; pfam01636 573236004085 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 573236004086 substrate binding site [chemical binding]; other site 573236004087 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 573236004088 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 573236004089 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 573236004090 active site 573236004091 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 573236004092 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 573236004093 putative active site [active] 573236004094 redox center [active] 573236004095 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 573236004096 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 573236004097 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 573236004098 glutamate racemase; Provisional; Region: PRK00865 573236004099 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 573236004100 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 573236004101 active site 573236004102 nucleophile elbow; other site 573236004103 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 573236004104 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 573236004105 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 573236004106 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 573236004107 substrate binding pocket [chemical binding]; other site 573236004108 membrane-bound complex binding site; other site 573236004109 hinge residues; other site 573236004110 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 573236004111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236004112 Walker A/P-loop; other site 573236004113 ATP binding site [chemical binding]; other site 573236004114 Q-loop/lid; other site 573236004115 ABC transporter signature motif; other site 573236004116 Walker B; other site 573236004117 D-loop; other site 573236004118 H-loop/switch region; other site 573236004119 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573236004120 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236004121 dimer interface [polypeptide binding]; other site 573236004122 conserved gate region; other site 573236004123 putative PBP binding loops; other site 573236004124 ABC-ATPase subunit interface; other site 573236004125 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 573236004126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236004127 dimer interface [polypeptide binding]; other site 573236004128 conserved gate region; other site 573236004129 putative PBP binding loops; other site 573236004130 ABC-ATPase subunit interface; other site 573236004131 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 573236004132 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236004133 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236004134 homodimer interface [polypeptide binding]; other site 573236004135 catalytic residue [active] 573236004136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236004137 putative PBP binding loops; other site 573236004138 ABC-ATPase subunit interface; other site 573236004139 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 573236004140 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 573236004141 Walker A/P-loop; other site 573236004142 ATP binding site [chemical binding]; other site 573236004143 Q-loop/lid; other site 573236004144 ABC transporter signature motif; other site 573236004145 Walker B; other site 573236004146 D-loop; other site 573236004147 H-loop/switch region; other site 573236004148 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 573236004149 NIL domain; Region: NIL; pfam09383 573236004150 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 573236004151 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 573236004152 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 573236004153 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 573236004154 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 573236004155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 573236004156 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 573236004157 active site 573236004158 catalytic site [active] 573236004159 substrate binding site [chemical binding]; other site 573236004160 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 573236004161 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 573236004162 G1 box; other site 573236004163 putative GEF interaction site [polypeptide binding]; other site 573236004164 GTP/Mg2+ binding site [chemical binding]; other site 573236004165 Switch I region; other site 573236004166 G2 box; other site 573236004167 G3 box; other site 573236004168 Switch II region; other site 573236004169 G4 box; other site 573236004170 G5 box; other site 573236004171 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 573236004172 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 573236004173 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 573236004174 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 573236004175 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 573236004176 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 573236004177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236004178 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236004179 putative substrate translocation pore; other site 573236004180 Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842 573236004181 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 573236004182 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573236004183 HIGH motif; other site 573236004184 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 573236004185 active site 573236004186 KMSKS motif; other site 573236004187 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 573236004188 tRNA binding surface [nucleotide binding]; other site 573236004189 anticodon binding site; other site 573236004190 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 573236004191 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 573236004192 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573236004193 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573236004194 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 573236004195 Walker A/P-loop; other site 573236004196 ATP binding site [chemical binding]; other site 573236004197 Q-loop/lid; other site 573236004198 ABC transporter signature motif; other site 573236004199 Walker B; other site 573236004200 D-loop; other site 573236004201 H-loop/switch region; other site 573236004202 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573236004203 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573236004204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236004205 Walker A/P-loop; other site 573236004206 ATP binding site [chemical binding]; other site 573236004207 Q-loop/lid; other site 573236004208 ABC transporter signature motif; other site 573236004209 Walker B; other site 573236004210 D-loop; other site 573236004211 H-loop/switch region; other site 573236004212 MarR family; Region: MarR_2; pfam12802 573236004213 Transcriptional regulators [Transcription]; Region: MarR; COG1846 573236004214 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 573236004215 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 573236004216 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 573236004217 mismatch recognition site; other site 573236004218 additional DNA contacts [nucleotide binding]; other site 573236004219 active site 573236004220 zinc binding site [ion binding]; other site 573236004221 DNA intercalation site [nucleotide binding]; other site 573236004222 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 573236004223 FIC domain binding interface [polypeptide binding]; other site 573236004224 CRISPR/Cas system-associated RAMP superfamily protein Csb3; Region: Csb3_I-U; cd09764 573236004225 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573236004226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 573236004227 CRISPR-associated protein GSU0054/csb2, Dpsyc system; Region: cas_GSU0054; TIGR02165 573236004228 CRISPR/Cas system-associated protein Csb1; Region: Csb1_I-U; cl09834 573236004229 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 573236004230 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 573236004231 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 573236004232 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 573236004233 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 573236004234 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 573236004235 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 573236004236 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 573236004237 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 573236004238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 573236004239 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 573236004240 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 573236004241 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 573236004242 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 573236004243 FeS/SAM binding site; other site 573236004244 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 573236004245 ATP cone domain; Region: ATP-cone; pfam03477 573236004246 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 573236004247 Class III ribonucleotide reductase; Region: RNR_III; cd01675 573236004248 active site 573236004249 Zn binding site [ion binding]; other site 573236004250 glycine loop; other site 573236004251 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 573236004252 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 573236004253 generic binding surface II; other site 573236004254 generic binding surface I; other site 573236004255 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 573236004256 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 573236004257 putative catalytic site [active] 573236004258 putative metal binding site [ion binding]; other site 573236004259 putative phosphate binding site [ion binding]; other site 573236004260 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 573236004261 aminotransferase; Validated; Region: PRK07337 573236004262 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 573236004263 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236004264 homodimer interface [polypeptide binding]; other site 573236004265 catalytic residue [active] 573236004266 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 573236004267 additional DNA contacts [nucleotide binding]; other site 573236004268 mismatch recognition site; other site 573236004269 active site 573236004270 zinc binding site [ion binding]; other site 573236004271 DNA intercalation site [nucleotide binding]; other site 573236004272 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 573236004273 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 573236004274 active site 573236004275 catalytic site [active] 573236004276 substrate binding site [chemical binding]; other site 573236004277 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 573236004278 active site 573236004279 catalytic residues [active] 573236004280 metal binding site [ion binding]; metal-binding site 573236004281 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 573236004282 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 573236004283 active site 573236004284 substrate binding site [chemical binding]; other site 573236004285 metal binding site [ion binding]; metal-binding site 573236004286 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 573236004287 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 573236004288 Zn binding site [ion binding]; other site 573236004289 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 573236004290 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 573236004291 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 573236004292 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 573236004293 dihydrodipicolinate synthase; Region: dapA; TIGR00674 573236004294 dimer interface [polypeptide binding]; other site 573236004295 active site 573236004296 catalytic residue [active] 573236004297 dihydrodipicolinate reductase; Provisional; Region: PRK00048 573236004298 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 573236004299 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 573236004300 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236004301 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236004302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 573236004303 Coenzyme A binding pocket [chemical binding]; other site 573236004304 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 573236004305 Family description; Region: UvrD_C_2; pfam13538 573236004306 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573236004307 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 573236004308 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573236004309 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573236004310 active site 573236004311 ATP binding site [chemical binding]; other site 573236004312 substrate binding site [chemical binding]; other site 573236004313 activation loop (A-loop); other site 573236004314 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573236004315 Interdomain contacts; other site 573236004316 Cytokine receptor motif; other site 573236004317 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 573236004318 Interdomain contacts; other site 573236004319 Cytokine receptor motif; other site 573236004320 MoxR-like ATPases [General function prediction only]; Region: COG0714 573236004321 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236004322 Walker A motif; other site 573236004323 ATP binding site [chemical binding]; other site 573236004324 Walker B motif; other site 573236004325 arginine finger; other site 573236004326 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 573236004327 Protein of unknown function DUF58; Region: DUF58; pfam01882 573236004328 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 573236004329 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 573236004330 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 573236004331 phosphopeptide binding site; other site 573236004332 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 573236004333 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 573236004334 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 573236004335 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 573236004336 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 573236004337 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 573236004338 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 573236004339 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 573236004340 DNA binding site [nucleotide binding] 573236004341 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 573236004342 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 573236004343 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 573236004344 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 573236004345 RPB1 interaction site [polypeptide binding]; other site 573236004346 RPB10 interaction site [polypeptide binding]; other site 573236004347 RPB11 interaction site [polypeptide binding]; other site 573236004348 RPB3 interaction site [polypeptide binding]; other site 573236004349 RPB12 interaction site [polypeptide binding]; other site 573236004350 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573236004351 endonuclease III; Region: ENDO3c; smart00478 573236004352 minor groove reading motif; other site 573236004353 helix-hairpin-helix signature motif; other site 573236004354 substrate binding pocket [chemical binding]; other site 573236004355 active site 573236004356 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 573236004357 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 573236004358 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 573236004359 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 573236004360 active site 573236004361 catalytic site [active] 573236004362 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 573236004363 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 573236004364 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573236004365 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 573236004366 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 573236004367 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 573236004368 dimer interface [polypeptide binding]; other site 573236004369 active site 573236004370 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 573236004371 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 573236004372 DNA-binding site [nucleotide binding]; DNA binding site 573236004373 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 573236004374 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 573236004375 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 573236004376 Ligand binding site; other site 573236004377 Putative Catalytic site; other site 573236004378 DXD motif; other site 573236004379 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 573236004380 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 573236004381 quinone interaction residues [chemical binding]; other site 573236004382 active site 573236004383 catalytic residues [active] 573236004384 FMN binding site [chemical binding]; other site 573236004385 substrate binding site [chemical binding]; other site 573236004386 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 573236004387 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 573236004388 active site 573236004389 FMN binding site [chemical binding]; other site 573236004390 substrate binding site [chemical binding]; other site 573236004391 homotetramer interface [polypeptide binding]; other site 573236004392 catalytic residue [active] 573236004393 Transglycosylase; Region: Transgly; pfam00912 573236004394 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 573236004395 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 573236004396 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 573236004397 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 573236004398 ligand binding site [chemical binding]; other site 573236004399 flexible hinge region; other site 573236004400 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 573236004401 putative switch regulator; other site 573236004402 non-specific DNA interactions [nucleotide binding]; other site 573236004403 DNA binding site [nucleotide binding] 573236004404 sequence specific DNA binding site [nucleotide binding]; other site 573236004405 putative cAMP binding site [chemical binding]; other site 573236004406 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 573236004407 TM2 domain; Region: TM2; pfam05154 573236004408 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 573236004409 tartrate dehydrogenase; Region: TTC; TIGR02089 573236004410 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 573236004411 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573236004412 Uncharacterized conserved protein [Function unknown]; Region: COG4850 573236004413 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 573236004414 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 573236004415 lipoyl attachment site [posttranslational modification]; other site 573236004416 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 573236004417 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 573236004418 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 573236004419 putative NADH binding site [chemical binding]; other site 573236004420 putative active site [active] 573236004421 nudix motif; other site 573236004422 putative metal binding site [ion binding]; other site 573236004423 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573236004424 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 573236004425 nudix motif; other site 573236004426 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 573236004427 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 573236004428 catalytic residues [active] 573236004429 Domain of unknown function (DUF348); Region: DUF348; pfam03990 573236004430 G5 domain; Region: G5; pfam07501 573236004431 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573236004432 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573236004433 catalytic residue [active] 573236004434 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 573236004435 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573236004436 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 573236004437 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 573236004438 Putative Catalytic site; other site 573236004439 DXD motif; other site 573236004440 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 573236004441 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 573236004442 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 573236004443 substrate binding site; other site 573236004444 tetramer interface; other site 573236004445 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 573236004446 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 573236004447 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 573236004448 NADP binding site [chemical binding]; other site 573236004449 active site 573236004450 putative substrate binding site [chemical binding]; other site 573236004451 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 573236004452 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 573236004453 NAD binding site [chemical binding]; other site 573236004454 substrate binding site [chemical binding]; other site 573236004455 homodimer interface [polypeptide binding]; other site 573236004456 active site 573236004457 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 573236004458 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 573236004459 Probable Catalytic site; other site 573236004460 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573236004461 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 573236004462 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573236004463 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573236004464 active site 573236004465 putative glycosyl transferase; Provisional; Region: PRK10073 573236004466 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 573236004467 active site 573236004468 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573236004469 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 573236004470 active site 573236004471 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 573236004472 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573236004473 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 573236004474 active site 573236004475 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 573236004476 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 573236004477 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 573236004478 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 573236004479 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 573236004480 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 573236004481 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 573236004482 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573236004483 active site 573236004484 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 573236004485 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 573236004486 Bacterial sugar transferase; Region: Bac_transf; pfam02397 573236004487 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236004488 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236004489 putative substrate translocation pore; other site 573236004490 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236004491 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 573236004492 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 573236004493 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 573236004494 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 573236004495 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 573236004496 active site 573236004497 multimer interface [polypeptide binding]; other site 573236004498 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 573236004499 predicted active site [active] 573236004500 catalytic triad [active] 573236004501 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 573236004502 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 573236004503 putative NAD(P) binding site [chemical binding]; other site 573236004504 active site 573236004505 putative substrate binding site [chemical binding]; other site 573236004506 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 573236004507 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 573236004508 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573236004509 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573236004510 active site 573236004511 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 573236004512 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 573236004513 Ligand binding site; other site 573236004514 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573236004515 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 573236004516 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236004517 Walker A/P-loop; other site 573236004518 ATP binding site [chemical binding]; other site 573236004519 Q-loop/lid; other site 573236004520 ABC transporter signature motif; other site 573236004521 Walker B; other site 573236004522 D-loop; other site 573236004523 H-loop/switch region; other site 573236004524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573236004525 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236004526 Walker A/P-loop; other site 573236004527 ATP binding site [chemical binding]; other site 573236004528 Q-loop/lid; other site 573236004529 ABC transporter signature motif; other site 573236004530 Walker B; other site 573236004531 D-loop; other site 573236004532 H-loop/switch region; other site 573236004533 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 573236004534 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 573236004535 acyl-activating enzyme (AAE) consensus motif; other site 573236004536 putative AMP binding site [chemical binding]; other site 573236004537 putative active site [active] 573236004538 putative CoA binding site [chemical binding]; other site 573236004539 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 573236004540 putative active site [active] 573236004541 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 573236004542 dimer interface [polypeptide binding]; other site 573236004543 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 573236004544 nudix motif; other site 573236004545 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 573236004546 Low molecular weight phosphatase family; Region: LMWPc; cd00115 573236004547 active site 573236004548 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 573236004549 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 573236004550 Chain length determinant protein; Region: Wzz; cl15801 573236004551 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 573236004552 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 573236004553 Nucleotide binding site [chemical binding]; other site 573236004554 DTAP/Switch II; other site 573236004555 Switch I; other site 573236004556 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 573236004557 Transposase; Region: DDE_Tnp_ISL3; pfam01610 573236004558 homoserine kinase; Provisional; Region: PRK01212 573236004559 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 573236004560 homoserine dehydrogenase; Provisional; Region: PRK06349 573236004561 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 573236004562 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 573236004563 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 573236004564 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 573236004565 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 573236004566 catalytic residue [active] 573236004567 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 573236004568 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573236004569 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 573236004570 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 573236004571 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 573236004572 active site 573236004573 HIGH motif; other site 573236004574 KMSK motif region; other site 573236004575 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 573236004576 tRNA binding surface [nucleotide binding]; other site 573236004577 anticodon binding site; other site 573236004578 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 573236004579 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 573236004580 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 573236004581 homotrimer interaction site [polypeptide binding]; other site 573236004582 putative active site [active] 573236004583 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573236004584 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236004585 dimer interface [polypeptide binding]; other site 573236004586 conserved gate region; other site 573236004587 putative PBP binding loops; other site 573236004588 ABC-ATPase subunit interface; other site 573236004589 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 573236004590 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 573236004591 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 573236004592 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 573236004593 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 573236004594 hypothetical protein; Provisional; Region: PRK03298 573236004595 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 573236004596 gamma subunit interface [polypeptide binding]; other site 573236004597 epsilon subunit interface [polypeptide binding]; other site 573236004598 LBP interface [polypeptide binding]; other site 573236004599 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 573236004600 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573236004601 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 573236004602 alpha subunit interaction interface [polypeptide binding]; other site 573236004603 Walker A motif; other site 573236004604 ATP binding site [chemical binding]; other site 573236004605 Walker B motif; other site 573236004606 inhibitor binding site; inhibition site 573236004607 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573236004608 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 573236004609 core domain interface [polypeptide binding]; other site 573236004610 delta subunit interface [polypeptide binding]; other site 573236004611 epsilon subunit interface [polypeptide binding]; other site 573236004612 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 573236004613 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 573236004614 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 573236004615 beta subunit interaction interface [polypeptide binding]; other site 573236004616 Walker A motif; other site 573236004617 ATP binding site [chemical binding]; other site 573236004618 Walker B motif; other site 573236004619 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 573236004620 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 573236004621 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 573236004622 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 573236004623 ATP synthase subunit C; Region: ATP-synt_C; cl00466 573236004624 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 573236004625 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 573236004626 homoserine O-succinyltransferase; Provisional; Region: PRK05368 573236004627 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 573236004628 proposed active site lysine [active] 573236004629 conserved cys residue [active] 573236004630 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236004631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236004632 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 573236004633 active site 573236004634 tetramer interface [polypeptide binding]; other site 573236004635 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 573236004636 Plasmid replication protein; Region: Rep_2; pfam01719 573236004637 Protein of unknown function DUF262; Region: DUF262; pfam03235 573236004638 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 573236004639 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 573236004640 active site 573236004641 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 573236004642 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 573236004643 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 573236004644 Int/Topo IB signature motif; other site 573236004645 formyl-coenzyme A transferase; Provisional; Region: PRK05398 573236004646 CoA-transferase family III; Region: CoA_transf_3; pfam02515 573236004647 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 573236004648 Cellulose or protein binding domain; Region: CBM_10; pfam02013 573236004649 Membrane transport protein; Region: Mem_trans; cl09117 573236004650 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 573236004651 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 573236004652 PYR/PP interface [polypeptide binding]; other site 573236004653 dimer interface [polypeptide binding]; other site 573236004654 TPP binding site [chemical binding]; other site 573236004655 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 573236004656 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 573236004657 TPP-binding site; other site 573236004658 dimer interface [polypeptide binding]; other site 573236004659 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 573236004660 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 573236004661 Cl- selectivity filter; other site 573236004662 Cl- binding residues [ion binding]; other site 573236004663 pore gating glutamate residue; other site 573236004664 dimer interface [polypeptide binding]; other site 573236004665 TQXA domain; Region: TQXA_dom; TIGR03934 573236004666 Cna protein B-type domain; Region: Cna_B; pfam05738 573236004667 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 573236004668 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 573236004669 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 573236004670 active site 573236004671 catalytic site [active] 573236004672 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 573236004673 dimer interface [polypeptide binding]; other site 573236004674 substrate binding site [chemical binding]; other site 573236004675 metal binding sites [ion binding]; metal-binding site 573236004676 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 573236004677 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 573236004678 DNA binding site [nucleotide binding] 573236004679 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 573236004680 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 573236004681 minor groove reading motif; other site 573236004682 helix-hairpin-helix signature motif; other site 573236004683 substrate binding pocket [chemical binding]; other site 573236004684 active site 573236004685 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 573236004686 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 573236004687 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 573236004688 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 573236004689 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573236004690 active site 573236004691 HIGH motif; other site 573236004692 nucleotide binding site [chemical binding]; other site 573236004693 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 573236004694 active site 573236004695 KMSKS motif; other site 573236004696 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 573236004697 tRNA binding surface [nucleotide binding]; other site 573236004698 anticodon binding site; other site 573236004699 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 573236004700 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 573236004701 dimerization interface [polypeptide binding]; other site 573236004702 putative Zn2+ binding site [ion binding]; other site 573236004703 putative DNA binding site [nucleotide binding]; other site 573236004704 chorismate mutase; Provisional; Region: PRK09239 573236004705 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 573236004706 transcription termination factor Rho; Provisional; Region: PRK12608 573236004707 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 573236004708 RNA binding site [nucleotide binding]; other site 573236004709 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 573236004710 Walker A motif; other site 573236004711 ATP binding site [chemical binding]; other site 573236004712 Walker B motif; other site 573236004713 hypothetical protein; Provisional; Region: PRK07208 573236004714 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573236004715 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 573236004716 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 573236004717 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 573236004718 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 573236004719 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 573236004720 GatB domain; Region: GatB_Yqey; pfam02637 573236004721 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 573236004722 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 573236004723 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 573236004724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236004725 ABC transporter signature motif; other site 573236004726 Walker B; other site 573236004727 D-loop; other site 573236004728 H-loop/switch region; other site 573236004729 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 573236004730 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 573236004731 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573236004732 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573236004733 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 573236004734 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 573236004735 Clp amino terminal domain; Region: Clp_N; pfam02861 573236004736 Clp amino terminal domain; Region: Clp_N; pfam02861 573236004737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236004738 Walker A motif; other site 573236004739 ATP binding site [chemical binding]; other site 573236004740 Walker B motif; other site 573236004741 arginine finger; other site 573236004742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 573236004743 Walker A motif; other site 573236004744 ATP binding site [chemical binding]; other site 573236004745 Walker B motif; other site 573236004746 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 573236004747 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 573236004748 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 573236004749 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 573236004750 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 573236004751 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 573236004752 metal ion-dependent adhesion site (MIDAS); other site 573236004753 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 573236004754 active site 573236004755 catalytic site [active] 573236004756 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 573236004757 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 573236004758 catalytic residue [active] 573236004759 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 573236004760 active site 573236004761 HIGH motif; other site 573236004762 nucleotide binding site [chemical binding]; other site 573236004763 active site 573236004764 KMSKS motif; other site 573236004765 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 573236004766 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 573236004767 amphipathic channel; other site 573236004768 Asn-Pro-Ala signature motifs; other site 573236004769 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 573236004770 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 573236004771 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 573236004772 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 573236004773 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 573236004774 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 573236004775 dimer interface [polypeptide binding]; other site 573236004776 ssDNA binding site [nucleotide binding]; other site 573236004777 tetramer (dimer of dimers) interface [polypeptide binding]; other site 573236004778 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 573236004779 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 573236004780 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 573236004781 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 573236004782 active site 573236004783 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 573236004784 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 573236004785 substrate binding site [chemical binding]; other site 573236004786 dimer interface [polypeptide binding]; other site 573236004787 ATP binding site [chemical binding]; other site 573236004788 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 573236004789 Major Facilitator Superfamily; Region: MFS_1; pfam07690 573236004790 putative substrate translocation pore; other site 573236004791 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 573236004792 active site 573236004793 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236004794 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236004795 DNA binding site [nucleotide binding] 573236004796 domain linker motif; other site 573236004797 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573236004798 dimerization interface [polypeptide binding]; other site 573236004799 ligand binding site [chemical binding]; other site 573236004800 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 573236004801 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 573236004802 UDP-galactopyranose mutase; Region: GLF; pfam03275 573236004803 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573236004804 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573236004805 active site 573236004806 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573236004807 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573236004808 active site 573236004809 Sulfatase; Region: Sulfatase; pfam00884 573236004810 Sulfatase; Region: Sulfatase; pfam00884 573236004811 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 573236004812 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573236004813 active site 573236004814 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 573236004815 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 573236004816 active site 573236004817 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 573236004818 active site 573236004819 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 573236004820 S-layer homology domain; Region: SLH; pfam00395 573236004821 S-layer homology domain; Region: SLH; pfam00395 573236004822 S-layer homology domain; Region: SLH; pfam00395 573236004823 MULE transposase domain; Region: MULE; pfam10551 573236004824 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 573236004825 Leucine rich repeat; Region: LRR_8; pfam13855 573236004826 S-layer homology domain; Region: SLH; pfam00395 573236004827 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 573236004828 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 573236004829 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 573236004830 Walker A/P-loop; other site 573236004831 ATP binding site [chemical binding]; other site 573236004832 Q-loop/lid; other site 573236004833 ABC transporter signature motif; other site 573236004834 Walker B; other site 573236004835 D-loop; other site 573236004836 H-loop/switch region; other site 573236004837 ABC-2 type transporter; Region: ABC2_membrane; cl17235 573236004838 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 573236004839 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 573236004840 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 573236004841 active site 573236004842 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 573236004843 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 573236004844 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 573236004845 FtsX-like permease family; Region: FtsX; pfam02687 573236004846 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 573236004847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236004848 ATP binding site [chemical binding]; other site 573236004849 Q-loop/lid; other site 573236004850 ABC transporter signature motif; other site 573236004851 Walker B; other site 573236004852 D-loop; other site 573236004853 H-loop/switch region; other site 573236004854 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573236004855 Zn2+ binding site [ion binding]; other site 573236004856 Mg2+ binding site [ion binding]; other site 573236004857 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 573236004858 putative active site [active] 573236004859 putative dimer interface [polypeptide binding]; other site 573236004860 YL1 nuclear protein; Region: YL1; pfam05764 573236004861 K+ potassium transporter; Region: K_trans; pfam02705 573236004862 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 573236004863 active site 573236004864 Melibiase; Region: Melibiase; pfam02065 573236004865 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573236004866 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573236004867 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 573236004868 Walker A/P-loop; other site 573236004869 ATP binding site [chemical binding]; other site 573236004870 Q-loop/lid; other site 573236004871 ABC transporter signature motif; other site 573236004872 Walker B; other site 573236004873 D-loop; other site 573236004874 H-loop/switch region; other site 573236004875 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 573236004876 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 573236004877 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 573236004878 Walker A/P-loop; other site 573236004879 ATP binding site [chemical binding]; other site 573236004880 Q-loop/lid; other site 573236004881 ABC transporter signature motif; other site 573236004882 Walker B; other site 573236004883 D-loop; other site 573236004884 H-loop/switch region; other site 573236004885 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 573236004886 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 573236004887 active site 573236004888 HIGH motif; other site 573236004889 KMSKS motif; other site 573236004890 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 573236004891 tRNA binding surface [nucleotide binding]; other site 573236004892 anticodon binding site; other site 573236004893 Predicted methyltransferases [General function prediction only]; Region: COG0313 573236004894 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 573236004895 putative SAM binding site [chemical binding]; other site 573236004896 putative homodimer interface [polypeptide binding]; other site 573236004897 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 573236004898 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 573236004899 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 573236004900 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 573236004901 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 573236004902 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 573236004903 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 573236004904 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 573236004905 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 573236004906 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 573236004907 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 573236004908 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 573236004909 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 573236004910 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236004911 motif II; other site 573236004912 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 573236004913 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 573236004914 DNA binding residues [nucleotide binding] 573236004915 putative dimer interface [polypeptide binding]; other site 573236004916 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 573236004917 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 573236004918 HSP70 interaction site [polypeptide binding]; other site 573236004919 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 573236004920 substrate binding site [polypeptide binding]; other site 573236004921 dimer interface [polypeptide binding]; other site 573236004922 GrpE; Region: GrpE; pfam01025 573236004923 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 573236004924 dimer interface [polypeptide binding]; other site 573236004925 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 573236004926 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 573236004927 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 573236004928 nucleotide binding site [chemical binding]; other site 573236004929 NEF interaction site [polypeptide binding]; other site 573236004930 SBD interface [polypeptide binding]; other site 573236004931 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236004932 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236004933 DNA binding site [nucleotide binding] 573236004934 domain linker motif; other site 573236004935 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573236004936 ligand binding site [chemical binding]; other site 573236004937 dimerization interface [polypeptide binding]; other site 573236004938 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 573236004939 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236004940 motif II; other site 573236004941 pullulanase, type I; Region: pulA_typeI; TIGR02104 573236004942 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 573236004943 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 573236004944 Ca binding site [ion binding]; other site 573236004945 active site 573236004946 catalytic site [active] 573236004947 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573236004948 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236004949 dimer interface [polypeptide binding]; other site 573236004950 conserved gate region; other site 573236004951 putative PBP binding loops; other site 573236004952 ABC-ATPase subunit interface; other site 573236004953 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 573236004954 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236004955 dimer interface [polypeptide binding]; other site 573236004956 conserved gate region; other site 573236004957 putative PBP binding loops; other site 573236004958 ABC-ATPase subunit interface; other site 573236004959 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 573236004960 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573236004961 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 573236004962 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 573236004963 active site 573236004964 catalytic site [active] 573236004965 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 573236004966 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 573236004967 Protein of unknown function, DUF624; Region: DUF624; pfam04854 573236004968 Protein of unknown function, DUF624; Region: DUF624; cl02369 573236004969 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573236004970 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236004971 dimer interface [polypeptide binding]; other site 573236004972 conserved gate region; other site 573236004973 putative PBP binding loops; other site 573236004974 ABC-ATPase subunit interface; other site 573236004975 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573236004976 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236004977 dimer interface [polypeptide binding]; other site 573236004978 conserved gate region; other site 573236004979 putative PBP binding loops; other site 573236004980 ABC-ATPase subunit interface; other site 573236004981 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236004982 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236004983 DNA binding site [nucleotide binding] 573236004984 domain linker motif; other site 573236004985 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573236004986 ligand binding site [chemical binding]; other site 573236004987 dimerization interface [polypeptide binding]; other site 573236004988 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573236004989 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 573236004990 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 573236004991 active site 573236004992 catalytic site [active] 573236004993 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 573236004994 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236004995 catalytic core [active] 573236004996 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 573236004997 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 573236004998 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 573236004999 dimer interface [polypeptide binding]; other site 573236005000 FMN binding site [chemical binding]; other site 573236005001 NADPH bind site [chemical binding]; other site 573236005002 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 573236005003 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 573236005004 active site 573236005005 catalytic triad [active] 573236005006 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 573236005007 RelB antitoxin; Region: RelB; cl01171 573236005008 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 573236005009 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 573236005010 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 573236005011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 573236005012 Transcriptional regulators [Transcription]; Region: PurR; COG1609 573236005013 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 573236005014 DNA binding site [nucleotide binding] 573236005015 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 573236005016 dimerization interface [polypeptide binding]; other site 573236005017 ligand binding site [chemical binding]; other site 573236005018 NAD-dependent deacetylase; Provisional; Region: PRK00481 573236005019 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 573236005020 threonine dehydratase; Provisional; Region: PRK08198 573236005021 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 573236005022 tetramer interface [polypeptide binding]; other site 573236005023 pyridoxal 5'-phosphate binding site [chemical binding]; other site 573236005024 catalytic residue [active] 573236005025 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 573236005026 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 573236005027 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 573236005028 Ca binding site [ion binding]; other site 573236005029 active site 573236005030 catalytic site [active] 573236005031 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 573236005032 Probable galactinol--sucrose galactosyltransferase; Region: PLN02684 573236005033 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 573236005034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236005035 dimer interface [polypeptide binding]; other site 573236005036 conserved gate region; other site 573236005037 putative PBP binding loops; other site 573236005038 ABC-ATPase subunit interface; other site 573236005039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 573236005040 dimer interface [polypeptide binding]; other site 573236005041 conserved gate region; other site 573236005042 putative PBP binding loops; other site 573236005043 ABC-ATPase subunit interface; other site 573236005044 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 573236005045 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 573236005046 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 573236005047 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 573236005048 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 573236005049 Melibiase; Region: Melibiase; pfam02065 573236005050 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 573236005051 nucleoside/Zn binding site; other site 573236005052 dimer interface [polypeptide binding]; other site 573236005053 catalytic motif [active] 573236005054 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 573236005055 Predicted esterase [General function prediction only]; Region: COG0400 573236005056 Serine hydrolase (FSH1); Region: FSH1; pfam03959 573236005057 Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348 573236005058 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 573236005059 trimer interface [polypeptide binding]; other site 573236005060 active site 573236005061 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 573236005062 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 573236005063 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 573236005064 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 573236005065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 573236005066 motif II; other site 573236005067 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 573236005068 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 573236005069 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 573236005070 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 573236005071 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 573236005072 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 573236005073 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 573236005074 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 573236005075 Walker A/P-loop; other site 573236005076 ATP binding site [chemical binding]; other site 573236005077 Q-loop/lid; other site 573236005078 ABC transporter signature motif; other site 573236005079 Walker B; other site 573236005080 D-loop; other site 573236005081 H-loop/switch region; other site 573236005082 TOBE domain; Region: TOBE_2; pfam08402 573236005083 Ion channel; Region: Ion_trans_2; pfam07885 573236005084 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 573236005085 Catalytic domain of Protein Kinases; Region: PKc; cd00180 573236005086 active site 573236005087 ATP binding site [chemical binding]; other site 573236005088 substrate binding site [chemical binding]; other site 573236005089 activation loop (A-loop); other site 573236005090 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 573236005091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 573236005092 Domain of unknown function (DUF348); Region: DUF348; pfam03990 573236005093 G5 domain; Region: G5; pfam07501 573236005094 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 573236005095 N-acetyl-D-glucosamine binding site [chemical binding]; other site 573236005096 catalytic residue [active] 573236005097 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 573236005098 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 573236005099 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 573236005100 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 573236005101 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 573236005102 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 573236005103 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 573236005104 active site 573236005105 NTP binding site [chemical binding]; other site 573236005106 metal binding triad [ion binding]; metal-binding site 573236005107 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 573236005108 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 573236005109 Zn2+ binding site [ion binding]; other site 573236005110 Mg2+ binding site [ion binding]; other site 573236005111 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 573236005112 active site 573236005113 Ap6A binding site [chemical binding]; other site 573236005114 nudix motif; other site 573236005115 metal binding site [ion binding]; metal-binding site 573236005116 integral membrane protein MviN; Region: mviN; TIGR01695 573236005117 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 573236005118 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 573236005119 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 573236005120 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 573236005121 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 573236005122 ParB-like nuclease domain; Region: ParB; smart00470 573236005123 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 573236005124 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 573236005125 P-loop; other site 573236005126 Magnesium ion binding site [ion binding]; other site 573236005127 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 573236005128 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 573236005129 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 573236005130 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 573236005131 G-X-X-G motif; other site 573236005132 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 573236005133 RxxxH motif; other site 573236005134 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 573236005135 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 573236005136 IncFII RepA protein family; Region: IncFII_repA; cl11495 573236005137 hypothetical protein; Provisional; Region: PRK14372 573236005138 Ribonuclease P; Region: Ribonuclease_P; pfam00825 573236005139 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399