-- dump date 20140619_002237 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1147128000001 chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14086 1147128000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128000003 Walker A motif; other site 1147128000004 ATP binding site [chemical binding]; other site 1147128000005 Walker B motif; other site 1147128000006 arginine finger; other site 1147128000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1147128000008 DnaA box-binding interface [nucleotide binding]; other site 1147128000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 1147128000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1147128000011 putative DNA binding surface [nucleotide binding]; other site 1147128000012 dimer interface [polypeptide binding]; other site 1147128000013 beta-clamp/clamp loader binding surface; other site 1147128000014 beta-clamp/translesion DNA polymerase binding surface; other site 1147128000015 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 1147128000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000017 Walker A/P-loop; other site 1147128000018 ATP binding site [chemical binding]; other site 1147128000019 Q-loop/lid; other site 1147128000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000021 ABC transporter signature motif; other site 1147128000022 Walker B; other site 1147128000023 D-loop; other site 1147128000024 H-loop/switch region; other site 1147128000025 Protein of unknown function (DUF721); Region: DUF721; cl02324 1147128000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1147128000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128000028 Mg2+ binding site [ion binding]; other site 1147128000029 G-X-G motif; other site 1147128000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1147128000031 anchoring element; other site 1147128000032 dimer interface [polypeptide binding]; other site 1147128000033 ATP binding site [chemical binding]; other site 1147128000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1147128000035 active site 1147128000036 putative metal-binding site [ion binding]; other site 1147128000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1147128000038 DNA gyrase subunit A; Validated; Region: PRK05560 1147128000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1147128000040 CAP-like domain; other site 1147128000041 active site 1147128000042 primary dimer interface [polypeptide binding]; other site 1147128000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1147128000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1147128000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1147128000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1147128000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1147128000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1147128000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 1147128000050 VanZ like family; Region: VanZ; pfam04892 1147128000051 EamA-like transporter family; Region: EamA; pfam00892 1147128000052 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1147128000053 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128000054 active site 1147128000055 phosphorylation site [posttranslational modification] 1147128000056 intermolecular recognition site; other site 1147128000057 dimerization interface [polypeptide binding]; other site 1147128000058 LytTr DNA-binding domain; Region: LytTR; smart00850 1147128000059 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 1147128000060 ATP binding site [chemical binding]; other site 1147128000061 Mg2+ binding site [ion binding]; other site 1147128000062 G-X-G motif; other site 1147128000063 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1147128000064 active site 1147128000065 Probable beta-xylosidase; Provisional; Region: PLN03080 1147128000066 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1147128000067 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1147128000068 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1147128000069 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1147128000070 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 1147128000071 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1147128000072 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1147128000073 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 1147128000074 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 1147128000075 HTH domain; Region: HTH_11; pfam08279 1147128000076 PRD domain; Region: PRD; pfam00874 1147128000077 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 1147128000078 active site 1147128000079 P-loop; other site 1147128000080 phosphorylation site [posttranslational modification] 1147128000081 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 1147128000082 active site 1147128000083 phosphorylation site [posttranslational modification] 1147128000084 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1147128000085 active site 1147128000086 phosphorylation site [posttranslational modification] 1147128000087 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1147128000088 active site 1147128000089 P-loop; other site 1147128000090 phosphorylation site [posttranslational modification] 1147128000091 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1147128000092 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1147128000093 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1147128000094 substrate binding site [chemical binding]; other site 1147128000095 hexamer interface [polypeptide binding]; other site 1147128000096 metal binding site [ion binding]; metal-binding site 1147128000097 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1147128000098 dimerization domain swap beta strand [polypeptide binding]; other site 1147128000099 regulatory protein interface [polypeptide binding]; other site 1147128000100 active site 1147128000101 regulatory phosphorylation site [posttranslational modification]; other site 1147128000102 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1147128000103 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1147128000104 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1147128000105 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1147128000106 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1147128000107 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 1147128000108 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128000109 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128000110 Walker A/P-loop; other site 1147128000111 ATP binding site [chemical binding]; other site 1147128000112 Q-loop/lid; other site 1147128000113 ABC transporter signature motif; other site 1147128000114 Walker B; other site 1147128000115 D-loop; other site 1147128000116 H-loop/switch region; other site 1147128000117 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1147128000118 FtsX-like permease family; Region: FtsX; pfam02687 1147128000119 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1147128000120 FtsX-like permease family; Region: FtsX; pfam02687 1147128000121 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1147128000122 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1147128000123 FtsX-like permease family; Region: FtsX; pfam02687 1147128000124 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128000125 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128000126 Walker A/P-loop; other site 1147128000127 ATP binding site [chemical binding]; other site 1147128000128 Q-loop/lid; other site 1147128000129 ABC transporter signature motif; other site 1147128000130 Walker B; other site 1147128000131 D-loop; other site 1147128000132 H-loop/switch region; other site 1147128000133 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1147128000134 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1147128000135 Walker A/P-loop; other site 1147128000136 ATP binding site [chemical binding]; other site 1147128000137 Q-loop/lid; other site 1147128000138 ABC transporter signature motif; other site 1147128000139 Walker B; other site 1147128000140 D-loop; other site 1147128000141 H-loop/switch region; other site 1147128000142 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1147128000143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000144 Walker A/P-loop; other site 1147128000145 ATP binding site [chemical binding]; other site 1147128000146 Q-loop/lid; other site 1147128000147 ABC transporter signature motif; other site 1147128000148 Walker B; other site 1147128000149 D-loop; other site 1147128000150 H-loop/switch region; other site 1147128000151 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1147128000152 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 1147128000153 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1147128000154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000155 Walker A/P-loop; other site 1147128000156 ATP binding site [chemical binding]; other site 1147128000157 Q-loop/lid; other site 1147128000158 ABC transporter signature motif; other site 1147128000159 Walker B; other site 1147128000160 D-loop; other site 1147128000161 H-loop/switch region; other site 1147128000162 thiol reductant ABC exporter, CydC subunit; Region: CydC; TIGR02868 1147128000163 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128000164 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000165 Walker A/P-loop; other site 1147128000166 ATP binding site [chemical binding]; other site 1147128000167 Q-loop/lid; other site 1147128000168 ABC transporter signature motif; other site 1147128000169 Walker B; other site 1147128000170 D-loop; other site 1147128000171 H-loop/switch region; other site 1147128000172 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1147128000173 YheO-like PAS domain; Region: PAS_6; pfam08348 1147128000174 HTH domain; Region: HTH_22; pfam13309 1147128000175 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1147128000176 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1147128000177 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128000178 homodimer interface [polypeptide binding]; other site 1147128000179 catalytic residue [active] 1147128000180 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 1147128000181 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 1147128000182 DNA methylase; Region: N6_N4_Mtase; pfam01555 1147128000183 DNA methylase; Region: N6_N4_Mtase; pfam01555 1147128000184 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1147128000185 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1147128000186 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 1147128000187 Abortive infection C-terminus; Region: Abi_C; pfam14355 1147128000188 Protein of unknown function DUF45; Region: DUF45; pfam01863 1147128000189 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1147128000190 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1147128000191 NAD(P) binding site [chemical binding]; other site 1147128000192 active site 1147128000193 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 1147128000194 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1147128000195 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1147128000196 dimerization interface [polypeptide binding]; other site 1147128000197 DPS ferroxidase diiron center [ion binding]; other site 1147128000198 ion pore; other site 1147128000199 Domain of unknown function DUF21; Region: DUF21; pfam01595 1147128000200 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1147128000201 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1147128000202 Transporter associated domain; Region: CorC_HlyC; smart01091 1147128000203 peroxiredoxin; Region: AhpC; TIGR03137 1147128000204 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1147128000205 dimer interface [polypeptide binding]; other site 1147128000206 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1147128000207 catalytic triad [active] 1147128000208 peroxidatic and resolving cysteines [active] 1147128000209 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 1147128000210 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1147128000211 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1147128000212 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1147128000213 catalytic residue [active] 1147128000214 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1147128000215 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128000216 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128000217 DNA binding site [nucleotide binding] 1147128000218 domain linker motif; other site 1147128000219 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128000220 dimerization interface [polypeptide binding]; other site 1147128000221 ligand binding site [chemical binding]; other site 1147128000222 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128000223 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128000224 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1147128000225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000226 dimer interface [polypeptide binding]; other site 1147128000227 conserved gate region; other site 1147128000228 putative PBP binding loops; other site 1147128000229 ABC-ATPase subunit interface; other site 1147128000230 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128000231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000232 dimer interface [polypeptide binding]; other site 1147128000233 conserved gate region; other site 1147128000234 putative PBP binding loops; other site 1147128000235 ABC-ATPase subunit interface; other site 1147128000236 Melibiase; Region: Melibiase; pfam02065 1147128000237 Melibiase; Region: Melibiase; pfam02065 1147128000238 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128000239 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1147128000240 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128000241 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128000242 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128000243 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128000244 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128000245 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128000246 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128000247 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128000248 IPT/TIG domain; Region: TIG; pfam01833 1147128000249 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1147128000250 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1147128000251 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1147128000252 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1147128000253 Protein of unknown function (DUF3815); Region: DUF3815; cl01118 1147128000254 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1147128000255 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1147128000256 active site 1147128000257 HIGH motif; other site 1147128000258 dimer interface [polypeptide binding]; other site 1147128000259 KMSKS motif; other site 1147128000260 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 1147128000261 Rhomboid family; Region: Rhomboid; pfam01694 1147128000262 putative septation inhibitor protein; Reviewed; Region: PRK02251 1147128000263 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1147128000264 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 1147128000265 active site 1147128000266 catalytic site [active] 1147128000267 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1147128000268 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1147128000269 active site 1147128000270 ATP binding site [chemical binding]; other site 1147128000271 substrate binding site [chemical binding]; other site 1147128000272 activation loop (A-loop); other site 1147128000273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1147128000274 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1147128000275 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1147128000276 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1147128000277 PASTA domain; Region: PASTA; smart00740 1147128000278 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1147128000279 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1147128000280 active site 1147128000281 ATP binding site [chemical binding]; other site 1147128000282 substrate binding site [chemical binding]; other site 1147128000283 activation loop (A-loop); other site 1147128000284 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1147128000285 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1147128000286 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1147128000287 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1147128000288 active site 1147128000289 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1147128000290 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1147128000291 phosphopeptide binding site; other site 1147128000292 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 1147128000293 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1147128000294 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1147128000295 phosphopeptide binding site; other site 1147128000296 Dipeptidyl peptidase IV (DPP IV) N-terminal region; Region: DPPIV_N; pfam00930 1147128000297 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 1147128000298 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1147128000299 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 1147128000300 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1147128000301 putative ion selectivity filter; other site 1147128000302 putative pore gating glutamate residue; other site 1147128000303 Predicted membrane protein [Function unknown]; Region: COG1511 1147128000304 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1147128000305 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1147128000306 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1147128000307 Predicted membrane protein [Function unknown]; Region: COG1511 1147128000308 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1147128000309 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1147128000310 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1147128000311 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1147128000312 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1147128000313 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1147128000314 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1147128000315 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1147128000316 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1147128000317 Uncharacterized conserved protein [Function unknown]; Region: COG3350 1147128000318 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1147128000319 putative homotetramer interface [polypeptide binding]; other site 1147128000320 putative homodimer interface [polypeptide binding]; other site 1147128000321 putative allosteric switch controlling residues; other site 1147128000322 putative metal binding site [ion binding]; other site 1147128000323 putative homodimer-homodimer interface [polypeptide binding]; other site 1147128000324 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1147128000325 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1147128000326 Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225 1147128000327 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1147128000328 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1147128000329 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1147128000330 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1147128000331 putative DNA binding site [nucleotide binding]; other site 1147128000332 putative Zn2+ binding site [ion binding]; other site 1147128000333 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1147128000334 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1147128000335 nucleotide binding site [chemical binding]; other site 1147128000336 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128000337 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128000338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000339 dimer interface [polypeptide binding]; other site 1147128000340 conserved gate region; other site 1147128000341 putative PBP binding loops; other site 1147128000342 ABC-ATPase subunit interface; other site 1147128000343 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128000344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000345 dimer interface [polypeptide binding]; other site 1147128000346 conserved gate region; other site 1147128000347 putative PBP binding loops; other site 1147128000348 ABC-ATPase subunit interface; other site 1147128000349 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1147128000350 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1147128000351 Metal-binding active site; metal-binding site 1147128000352 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 1147128000353 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1147128000354 NADP binding site [chemical binding]; other site 1147128000355 homodimer interface [polypeptide binding]; other site 1147128000356 active site 1147128000357 hypothetical protein; Provisional; Region: PRK09273 1147128000358 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 1147128000359 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 1147128000360 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1147128000361 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1147128000362 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1147128000363 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1147128000364 protein binding site [polypeptide binding]; other site 1147128000365 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 1147128000366 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1147128000367 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1147128000368 ferredoxin-NADP+ reductase; Region: PLN02852 1147128000369 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1147128000370 Domain of unknown function (DUF955); Region: DUF955; cl01076 1147128000371 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1147128000372 heat shock protein HtpX; Provisional; Region: PRK03072 1147128000373 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1147128000374 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128000375 active site 1147128000376 phosphorylation site [posttranslational modification] 1147128000377 intermolecular recognition site; other site 1147128000378 dimerization interface [polypeptide binding]; other site 1147128000379 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1147128000380 DNA binding residues [nucleotide binding] 1147128000381 dimerization interface [polypeptide binding]; other site 1147128000382 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1147128000383 Histidine kinase; Region: HisKA_3; pfam07730 1147128000384 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128000385 ATP binding site [chemical binding]; other site 1147128000386 Mg2+ binding site [ion binding]; other site 1147128000387 G-X-G motif; other site 1147128000388 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128000389 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1147128000390 Walker A/P-loop; other site 1147128000391 ATP binding site [chemical binding]; other site 1147128000392 Q-loop/lid; other site 1147128000393 ABC transporter signature motif; other site 1147128000394 Walker B; other site 1147128000395 D-loop; other site 1147128000396 H-loop/switch region; other site 1147128000397 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1147128000398 Amidohydrolase; Region: Amidohydro_4; pfam13147 1147128000399 active site 1147128000400 dimer interface [polypeptide binding]; other site 1147128000401 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1147128000402 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1147128000403 active site 1147128000404 trimer interface [polypeptide binding]; other site 1147128000405 allosteric site; other site 1147128000406 active site lid [active] 1147128000407 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1147128000408 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1147128000409 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1147128000410 nucleotide binding site [chemical binding]; other site 1147128000411 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 1147128000412 putative active cleft [active] 1147128000413 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1147128000414 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1147128000415 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1147128000416 Uncharacterized protein conserved in bacteria (DUF2188); Region: DUF2188; pfam09954 1147128000417 Predicted esterase [General function prediction only]; Region: COG0400 1147128000418 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 1147128000419 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1147128000420 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1147128000421 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1147128000422 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1147128000423 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1147128000424 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1147128000425 motif II; other site 1147128000426 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1147128000427 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1147128000428 nucleoside/Zn binding site; other site 1147128000429 dimer interface [polypeptide binding]; other site 1147128000430 catalytic motif [active] 1147128000431 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1147128000432 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1147128000433 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1147128000434 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1147128000435 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1147128000436 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1147128000437 Ca binding site [ion binding]; other site 1147128000438 active site 1147128000439 catalytic site [active] 1147128000440 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 1147128000441 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1147128000442 active site 1147128000443 homotetramer interface [polypeptide binding]; other site 1147128000444 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1147128000445 threonine dehydratase; Provisional; Region: PRK08198 1147128000446 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1147128000447 tetramer interface [polypeptide binding]; other site 1147128000448 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128000449 catalytic residue [active] 1147128000450 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 1147128000451 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128000452 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1147128000453 Walker A/P-loop; other site 1147128000454 ATP binding site [chemical binding]; other site 1147128000455 Q-loop/lid; other site 1147128000456 ABC transporter signature motif; other site 1147128000457 Walker B; other site 1147128000458 D-loop; other site 1147128000459 H-loop/switch region; other site 1147128000460 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1147128000461 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1147128000462 MULE transposase domain; Region: MULE; pfam10551 1147128000463 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128000464 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128000465 Walker A/P-loop; other site 1147128000466 ATP binding site [chemical binding]; other site 1147128000467 Q-loop/lid; other site 1147128000468 ABC transporter signature motif; other site 1147128000469 Walker B; other site 1147128000470 D-loop; other site 1147128000471 H-loop/switch region; other site 1147128000472 FtsX-like permease family; Region: FtsX; pfam02687 1147128000473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1147128000474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128000475 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128000476 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1147128000477 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000478 Walker A/P-loop; other site 1147128000479 ATP binding site [chemical binding]; other site 1147128000480 Q-loop/lid; other site 1147128000481 ABC transporter signature motif; other site 1147128000482 Walker B; other site 1147128000483 D-loop; other site 1147128000484 H-loop/switch region; other site 1147128000485 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1147128000486 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1147128000487 catalytic residues [active] 1147128000488 catalytic nucleophile [active] 1147128000489 Presynaptic Site I dimer interface [polypeptide binding]; other site 1147128000490 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1147128000491 Synaptic Flat tetramer interface [polypeptide binding]; other site 1147128000492 Synaptic Site I dimer interface [polypeptide binding]; other site 1147128000493 DNA binding site [nucleotide binding] 1147128000494 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1147128000495 DNA-binding interface [nucleotide binding]; DNA binding site 1147128000496 NAD-dependent deacetylase; Provisional; Region: PRK00481 1147128000497 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1147128000498 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 1147128000499 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1147128000500 NAD(P) binding site [chemical binding]; other site 1147128000501 putative active site [active] 1147128000502 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 1147128000503 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 1147128000504 Right handed beta helix region; Region: Beta_helix; pfam13229 1147128000505 Right handed beta helix region; Region: Beta_helix; pfam13229 1147128000506 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1147128000507 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1147128000508 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1147128000509 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1147128000510 active site 1147128000511 catalytic tetrad [active] 1147128000512 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1147128000513 dimer interface [polypeptide binding]; other site 1147128000514 FMN binding site [chemical binding]; other site 1147128000515 NADPH bind site [chemical binding]; other site 1147128000516 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 1147128000517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000518 dimer interface [polypeptide binding]; other site 1147128000519 conserved gate region; other site 1147128000520 putative PBP binding loops; other site 1147128000521 ABC-ATPase subunit interface; other site 1147128000522 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128000523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000524 dimer interface [polypeptide binding]; other site 1147128000525 conserved gate region; other site 1147128000526 putative PBP binding loops; other site 1147128000527 ABC-ATPase subunit interface; other site 1147128000528 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1147128000529 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1147128000530 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 1147128000531 putative active site [active] 1147128000532 putative catalytic site [active] 1147128000533 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128000534 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128000535 DNA binding site [nucleotide binding] 1147128000536 domain linker motif; other site 1147128000537 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128000538 ligand binding site [chemical binding]; other site 1147128000539 dimerization interface [polypeptide binding]; other site 1147128000540 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1147128000541 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1147128000542 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 1147128000543 active site 1147128000544 catalytic site [active] 1147128000545 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1147128000546 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1147128000547 nucleotide binding site [chemical binding]; other site 1147128000548 GrpE; Region: GrpE; pfam01025 1147128000549 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1147128000550 dimer interface [polypeptide binding]; other site 1147128000551 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1147128000552 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1147128000553 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1147128000554 HSP70 interaction site [polypeptide binding]; other site 1147128000555 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1147128000556 substrate binding site [polypeptide binding]; other site 1147128000557 dimer interface [polypeptide binding]; other site 1147128000558 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1147128000559 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1147128000560 DNA binding residues [nucleotide binding] 1147128000561 putative dimer interface [polypeptide binding]; other site 1147128000562 Predicted membrane protein [Function unknown]; Region: COG1511 1147128000563 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1147128000564 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 1147128000565 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 1147128000566 AAA domain; Region: AAA_14; pfam13173 1147128000567 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128000568 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128000569 DNA binding site [nucleotide binding] 1147128000570 domain linker motif; other site 1147128000571 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1147128000572 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1147128000573 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1147128000574 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000575 putative substrate translocation pore; other site 1147128000576 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1147128000577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1147128000578 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1147128000579 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1147128000580 active site 1147128000581 catalytic triad [active] 1147128000582 oxyanion hole [active] 1147128000583 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1147128000584 dinuclear metal binding motif [ion binding]; other site 1147128000585 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1147128000586 classical (c) SDRs; Region: SDR_c; cd05233 1147128000587 NAD(P) binding site [chemical binding]; other site 1147128000588 active site 1147128000589 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 1147128000590 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1147128000591 DNA binding residues [nucleotide binding] 1147128000592 putative dimer interface [polypeptide binding]; other site 1147128000593 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1147128000594 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1147128000595 ATP binding site [chemical binding]; other site 1147128000596 Mg++ binding site [ion binding]; other site 1147128000597 motif III; other site 1147128000598 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128000599 nucleotide binding region [chemical binding]; other site 1147128000600 ATP-binding site [chemical binding]; other site 1147128000601 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1147128000602 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1147128000603 DNA-binding site [nucleotide binding]; DNA binding site 1147128000604 FCD domain; Region: FCD; pfam07729 1147128000605 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1147128000606 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1147128000607 TPP-binding site [chemical binding]; other site 1147128000608 dimer interface [polypeptide binding]; other site 1147128000609 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1147128000610 PYR/PP interface [polypeptide binding]; other site 1147128000611 dimer interface [polypeptide binding]; other site 1147128000612 TPP binding site [chemical binding]; other site 1147128000613 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1147128000614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000615 putative substrate translocation pore; other site 1147128000616 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1147128000617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000618 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1147128000619 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1147128000620 active site pocket [active] 1147128000621 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1147128000622 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1147128000623 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1147128000624 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1147128000625 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1147128000626 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1147128000627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000628 dimer interface [polypeptide binding]; other site 1147128000629 conserved gate region; other site 1147128000630 putative PBP binding loops; other site 1147128000631 ABC-ATPase subunit interface; other site 1147128000632 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128000633 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000634 dimer interface [polypeptide binding]; other site 1147128000635 ABC-ATPase subunit interface; other site 1147128000636 Protein of unknown function, DUF624; Region: DUF624; cl02369 1147128000637 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128000638 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128000639 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1147128000640 Dolichyl-phosphate-mannose--protein O-mannosyl transferase [Posttranslational modification, protein turnover, chaperones]; Region: PMT1; COG1928 1147128000641 Predicted methyltransferases [General function prediction only]; Region: COG0313 1147128000642 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1147128000643 putative SAM binding site [chemical binding]; other site 1147128000644 putative homodimer interface [polypeptide binding]; other site 1147128000645 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 1147128000646 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1147128000647 active site 1147128000648 HIGH motif; other site 1147128000649 KMSKS motif; other site 1147128000650 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1147128000651 tRNA binding surface [nucleotide binding]; other site 1147128000652 anticodon binding site; other site 1147128000653 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1147128000654 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1147128000655 motif II; other site 1147128000656 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1147128000657 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1147128000658 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1147128000659 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128000660 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000661 Walker A/P-loop; other site 1147128000662 ATP binding site [chemical binding]; other site 1147128000663 Q-loop/lid; other site 1147128000664 ABC transporter signature motif; other site 1147128000665 Walker B; other site 1147128000666 D-loop; other site 1147128000667 H-loop/switch region; other site 1147128000668 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1147128000669 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128000670 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1147128000671 Walker A/P-loop; other site 1147128000672 ATP binding site [chemical binding]; other site 1147128000673 Q-loop/lid; other site 1147128000674 ABC transporter signature motif; other site 1147128000675 Walker B; other site 1147128000676 D-loop; other site 1147128000677 H-loop/switch region; other site 1147128000678 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1147128000679 active site 1147128000680 alpha-galactosidase; Region: PLN02808; cl17638 1147128000681 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1147128000682 substrate binding site [chemical binding]; other site 1147128000683 active site 1147128000684 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1147128000685 active site 1147128000686 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128000687 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128000688 DNA binding site [nucleotide binding] 1147128000689 domain linker motif; other site 1147128000690 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128000691 dimerization interface [polypeptide binding]; other site 1147128000692 ligand binding site [chemical binding]; other site 1147128000693 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1147128000694 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 1147128000695 substrate binding site [chemical binding]; other site 1147128000696 active site 1147128000697 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 1147128000698 active site 1147128000699 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1147128000700 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128000701 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1147128000702 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000703 dimer interface [polypeptide binding]; other site 1147128000704 conserved gate region; other site 1147128000705 putative PBP binding loops; other site 1147128000706 ABC-ATPase subunit interface; other site 1147128000707 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128000708 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000709 dimer interface [polypeptide binding]; other site 1147128000710 conserved gate region; other site 1147128000711 putative PBP binding loops; other site 1147128000712 ABC-ATPase subunit interface; other site 1147128000713 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1147128000714 active site 1147128000715 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1147128000716 active site 1147128000717 K+ potassium transporter; Region: K_trans; pfam02705 1147128000718 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1147128000719 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1147128000720 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1147128000721 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128000722 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128000723 DNA binding site [nucleotide binding] 1147128000724 domain linker motif; other site 1147128000725 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128000726 dimerization interface [polypeptide binding]; other site 1147128000727 ligand binding site [chemical binding]; other site 1147128000728 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128000729 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128000730 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000731 dimer interface [polypeptide binding]; other site 1147128000732 conserved gate region; other site 1147128000733 putative PBP binding loops; other site 1147128000734 ABC-ATPase subunit interface; other site 1147128000735 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128000736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000737 dimer interface [polypeptide binding]; other site 1147128000738 conserved gate region; other site 1147128000739 putative PBP binding loops; other site 1147128000740 ABC-ATPase subunit interface; other site 1147128000741 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1147128000742 active site 1147128000743 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1147128000744 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 1147128000745 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1147128000746 ATP-binding site [chemical binding]; other site 1147128000747 Gluconate-6-phosphate binding site [chemical binding]; other site 1147128000748 Shikimate kinase; Region: SKI; pfam01202 1147128000749 GntP family permease; Region: GntP_permease; pfam02447 1147128000750 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1147128000751 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1147128000752 DNA-binding site [nucleotide binding]; DNA binding site 1147128000753 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1147128000754 FCD domain; Region: FCD; pfam07729 1147128000755 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1147128000756 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1147128000757 putative active site [active] 1147128000758 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 1147128000759 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 1147128000760 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1147128000761 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1147128000762 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1147128000763 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1147128000764 Zn2+ binding site [ion binding]; other site 1147128000765 Mg2+ binding site [ion binding]; other site 1147128000766 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000767 Walker A/P-loop; other site 1147128000768 ATP binding site [chemical binding]; other site 1147128000769 ABC transporter; Region: ABC_tran; pfam00005 1147128000770 Q-loop/lid; other site 1147128000771 ABC transporter signature motif; other site 1147128000772 Walker B; other site 1147128000773 D-loop; other site 1147128000774 H-loop/switch region; other site 1147128000775 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1147128000776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000777 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128000778 putative substrate translocation pore; other site 1147128000779 SWIM zinc finger; Region: SWIM; pfam04434 1147128000780 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1147128000781 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1147128000782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128000783 ATP binding site [chemical binding]; other site 1147128000784 putative Mg++ binding site [ion binding]; other site 1147128000785 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128000786 nucleotide binding region [chemical binding]; other site 1147128000787 ATP-binding site [chemical binding]; other site 1147128000788 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1147128000789 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1147128000790 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1147128000791 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1147128000792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000793 dimer interface [polypeptide binding]; other site 1147128000794 conserved gate region; other site 1147128000795 putative PBP binding loops; other site 1147128000796 ABC-ATPase subunit interface; other site 1147128000797 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128000798 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000799 dimer interface [polypeptide binding]; other site 1147128000800 conserved gate region; other site 1147128000801 putative PBP binding loops; other site 1147128000802 ABC-ATPase subunit interface; other site 1147128000803 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1147128000804 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128000805 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128000806 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128000807 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128000808 DNA binding site [nucleotide binding] 1147128000809 domain linker motif; other site 1147128000810 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 1147128000811 putative ligand binding site [chemical binding]; other site 1147128000812 putative dimerization interface [polypeptide binding]; other site 1147128000813 Glycosyl hydrolase family 67 middle domain; Region: Glyco_hydro_67M; pfam07488 1147128000814 Glycosyl hydrolase family 67 C-terminus; Region: Glyco_hydro_67C; pfam07477 1147128000815 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1147128000816 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1147128000817 inhibitor binding site; inhibition site 1147128000818 active site 1147128000819 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1147128000820 amphipathic channel; other site 1147128000821 Asn-Pro-Ala signature motifs; other site 1147128000822 T surface-antigen of pili; Region: FctA; pfam12892 1147128000823 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 1147128000824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000825 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128000826 putative substrate translocation pore; other site 1147128000827 conserved hypothetical protein; Region: TIGR02328 1147128000828 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1147128000829 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1147128000830 NAD(P) binding site [chemical binding]; other site 1147128000831 short chain dehydrogenase; Validated; Region: PRK07069 1147128000832 active site 1147128000833 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 1147128000834 PLD-like domain; Region: PLDc_2; pfam13091 1147128000835 putative homodimer interface [polypeptide binding]; other site 1147128000836 putative active site [active] 1147128000837 catalytic site [active] 1147128000838 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 1147128000839 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128000840 ATP binding site [chemical binding]; other site 1147128000841 putative Mg++ binding site [ion binding]; other site 1147128000842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128000843 nucleotide binding region [chemical binding]; other site 1147128000844 ATP-binding site [chemical binding]; other site 1147128000845 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 1147128000846 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000847 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128000848 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1147128000849 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1147128000850 active site 1147128000851 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1147128000852 substrate binding site [chemical binding]; other site 1147128000853 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1147128000854 active site 1147128000855 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1147128000856 classical (c) SDRs; Region: SDR_c; cd05233 1147128000857 NAD(P) binding site [chemical binding]; other site 1147128000858 active site 1147128000859 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1147128000860 Isochorismatase family; Region: Isochorismatase; pfam00857 1147128000861 catalytic triad [active] 1147128000862 metal binding site [ion binding]; metal-binding site 1147128000863 conserved cis-peptide bond; other site 1147128000864 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1147128000865 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000866 Walker A/P-loop; other site 1147128000867 ATP binding site [chemical binding]; other site 1147128000868 Q-loop/lid; other site 1147128000869 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 1147128000870 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000871 ABC transporter signature motif; other site 1147128000872 Walker B; other site 1147128000873 D-loop; other site 1147128000874 H-loop/switch region; other site 1147128000875 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128000876 Walker A/P-loop; other site 1147128000877 ATP binding site [chemical binding]; other site 1147128000878 Q-loop/lid; other site 1147128000879 ABC transporter signature motif; other site 1147128000880 Walker B; other site 1147128000881 D-loop; other site 1147128000882 H-loop/switch region; other site 1147128000883 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1147128000884 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1147128000885 dimerization interface [polypeptide binding]; other site 1147128000886 putative Zn2+ binding site [ion binding]; other site 1147128000887 putative DNA binding site [nucleotide binding]; other site 1147128000888 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1147128000889 MarR family; Region: MarR_2; pfam12802 1147128000890 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000891 putative substrate translocation pore; other site 1147128000892 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000893 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 1147128000894 active site 1147128000895 catalytic triad [active] 1147128000896 oxyanion hole [active] 1147128000897 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1147128000898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000899 putative substrate translocation pore; other site 1147128000900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000901 Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753 1147128000902 Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156 1147128000903 tetramer interface [polypeptide binding]; other site 1147128000904 heme binding pocket [chemical binding]; other site 1147128000905 NADPH binding site [chemical binding]; other site 1147128000906 manganese transport protein MntH; Reviewed; Region: PRK00701 1147128000907 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1147128000908 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 1147128000909 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1147128000910 putative Zn2+ binding site [ion binding]; other site 1147128000911 putative DNA binding site [nucleotide binding]; other site 1147128000912 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1147128000913 This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899 1147128000914 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1147128000915 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1147128000916 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1147128000917 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 1147128000918 Probable Catalytic site; other site 1147128000919 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1147128000920 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1147128000921 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1147128000922 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1147128000923 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1147128000924 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1147128000925 Walker A/P-loop; other site 1147128000926 ATP binding site [chemical binding]; other site 1147128000927 Q-loop/lid; other site 1147128000928 ABC transporter signature motif; other site 1147128000929 Walker B; other site 1147128000930 D-loop; other site 1147128000931 H-loop/switch region; other site 1147128000932 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1147128000933 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1147128000934 NAD binding site [chemical binding]; other site 1147128000935 substrate binding site [chemical binding]; other site 1147128000936 homodimer interface [polypeptide binding]; other site 1147128000937 active site 1147128000938 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1147128000939 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1147128000940 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1147128000941 dimer interface [polypeptide binding]; other site 1147128000942 ssDNA binding site [nucleotide binding]; other site 1147128000943 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1147128000944 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1147128000945 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1147128000946 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1147128000947 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1147128000948 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 1147128000949 Predicted membrane protein [Function unknown]; Region: COG2246 1147128000950 GtrA-like protein; Region: GtrA; pfam04138 1147128000951 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128000952 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128000953 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1147128000954 catalytic core [active] 1147128000955 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1147128000956 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1147128000957 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128000958 dimer interface [polypeptide binding]; other site 1147128000959 conserved gate region; other site 1147128000960 putative PBP binding loops; other site 1147128000961 ABC-ATPase subunit interface; other site 1147128000962 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 1147128000963 NMT1/THI5 like; Region: NMT1; pfam09084 1147128000964 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128000965 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128000966 DNA binding site [nucleotide binding] 1147128000967 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1147128000968 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1147128000969 ATP cone domain; Region: ATP-cone; pfam03477 1147128000970 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1147128000971 effector binding site; other site 1147128000972 active site 1147128000973 Zn binding site [ion binding]; other site 1147128000974 glycine loop; other site 1147128000975 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 1147128000976 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1147128000977 FeS/SAM binding site; other site 1147128000978 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1147128000979 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1147128000980 active site 1147128000981 HIGH motif; other site 1147128000982 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1147128000983 active site 1147128000984 KMSKS motif; other site 1147128000985 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992 1147128000986 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1147128000987 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 1147128000988 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1147128000989 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1147128000990 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1147128000991 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1147128000992 Walker A/P-loop; other site 1147128000993 ATP binding site [chemical binding]; other site 1147128000994 Q-loop/lid; other site 1147128000995 ABC transporter signature motif; other site 1147128000996 Walker B; other site 1147128000997 D-loop; other site 1147128000998 H-loop/switch region; other site 1147128000999 ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987 1147128001000 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128001001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128001002 Walker A/P-loop; other site 1147128001003 ATP binding site [chemical binding]; other site 1147128001004 Q-loop/lid; other site 1147128001005 ABC transporter signature motif; other site 1147128001006 Walker B; other site 1147128001007 D-loop; other site 1147128001008 H-loop/switch region; other site 1147128001009 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 1147128001010 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1147128001011 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1147128001012 substrate binding pocket [chemical binding]; other site 1147128001013 chain length determination region; other site 1147128001014 substrate-Mg2+ binding site; other site 1147128001015 catalytic residues [active] 1147128001016 aspartate-rich region 1; other site 1147128001017 active site lid residues [active] 1147128001018 aspartate-rich region 2; other site 1147128001019 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1147128001020 metal binding site [ion binding]; metal-binding site 1147128001021 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1147128001022 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 1147128001023 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 1147128001024 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1147128001025 Bacterial transcriptional regulator; Region: IclR; pfam01614 1147128001026 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1147128001027 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1147128001028 substrate binding site [chemical binding]; other site 1147128001029 ligand binding site [chemical binding]; other site 1147128001030 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1147128001031 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1147128001032 substrate binding site [chemical binding]; other site 1147128001033 CAAX protease self-immunity; Region: Abi; pfam02517 1147128001034 CAAX protease self-immunity; Region: Abi; pfam02517 1147128001035 CAAX protease self-immunity; Region: Abi; pfam02517 1147128001036 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1147128001037 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1147128001038 hinge; other site 1147128001039 active site 1147128001040 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1147128001041 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1147128001042 putative acyl-acceptor binding pocket; other site 1147128001043 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1147128001044 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1147128001045 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1147128001046 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1147128001047 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1147128001048 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1147128001049 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1147128001050 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1147128001051 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1147128001052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1147128001053 Coenzyme A binding pocket [chemical binding]; other site 1147128001054 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1147128001055 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1147128001056 active site 1147128001057 substrate binding site [chemical binding]; other site 1147128001058 trimer interface [polypeptide binding]; other site 1147128001059 CoA binding site [chemical binding]; other site 1147128001060 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128001061 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128001062 Walker A/P-loop; other site 1147128001063 ATP binding site [chemical binding]; other site 1147128001064 Q-loop/lid; other site 1147128001065 ABC transporter signature motif; other site 1147128001066 Walker B; other site 1147128001067 D-loop; other site 1147128001068 H-loop/switch region; other site 1147128001069 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1147128001070 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1147128001071 non-specific DNA binding site [nucleotide binding]; other site 1147128001072 salt bridge; other site 1147128001073 sequence-specific DNA binding site [nucleotide binding]; other site 1147128001074 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1147128001075 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1147128001076 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1147128001077 ssDNA binding site; other site 1147128001078 generic binding surface II; other site 1147128001079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128001080 ATP binding site [chemical binding]; other site 1147128001081 putative Mg++ binding site [ion binding]; other site 1147128001082 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128001083 nucleotide binding region [chemical binding]; other site 1147128001084 ATP-binding site [chemical binding]; other site 1147128001085 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1147128001086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1147128001087 S-adenosylmethionine binding site [chemical binding]; other site 1147128001088 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1147128001089 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1147128001090 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1147128001091 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1147128001092 AAA domain; Region: AAA_33; pfam13671 1147128001093 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1147128001094 active site 1147128001095 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001096 D-galactonate transporter; Region: 2A0114; TIGR00893 1147128001097 putative substrate translocation pore; other site 1147128001098 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1147128001099 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 1147128001100 active site 1147128001101 intersubunit interface [polypeptide binding]; other site 1147128001102 catalytic residue [active] 1147128001103 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1147128001104 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1147128001105 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001106 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1147128001107 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1147128001108 putative active site [active] 1147128001109 CoB--CoM heterodisulfide reductase, subunit B; Region: CoB_CoM_SS_B; TIGR03288 1147128001110 Cysteine-rich domain; Region: CCG; pfam02754 1147128001111 Cysteine-rich domain; Region: CCG; pfam02754 1147128001112 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1147128001113 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 1147128001114 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1147128001115 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1147128001116 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1147128001117 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1147128001118 RimM N-terminal domain; Region: RimM; pfam01782 1147128001119 hypothetical protein; Provisional; Region: PRK02821 1147128001120 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1147128001121 G-X-X-G motif; other site 1147128001122 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 1147128001123 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1147128001124 putative catalytic site [active] 1147128001125 putative metal binding site [ion binding]; other site 1147128001126 putative phosphate binding site [ion binding]; other site 1147128001127 signal recognition particle protein; Provisional; Region: PRK10867 1147128001128 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1147128001129 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1147128001130 P loop; other site 1147128001131 GTP binding site [chemical binding]; other site 1147128001132 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1147128001133 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128001134 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128001135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128001136 dimer interface [polypeptide binding]; other site 1147128001137 conserved gate region; other site 1147128001138 putative PBP binding loops; other site 1147128001139 ABC-ATPase subunit interface; other site 1147128001140 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128001141 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128001142 dimer interface [polypeptide binding]; other site 1147128001143 conserved gate region; other site 1147128001144 ABC-ATPase subunit interface; other site 1147128001145 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1147128001146 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128001147 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128001148 DNA binding site [nucleotide binding] 1147128001149 domain linker motif; other site 1147128001150 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128001151 dimerization interface [polypeptide binding]; other site 1147128001152 ligand binding site [chemical binding]; other site 1147128001153 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1147128001154 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1147128001155 active site 1147128001156 HIGH motif; other site 1147128001157 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1147128001158 KMSKS motif; other site 1147128001159 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1147128001160 tRNA binding surface [nucleotide binding]; other site 1147128001161 anticodon binding site; other site 1147128001162 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1147128001163 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1147128001164 catalytic triad [active] 1147128001165 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1147128001166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1147128001167 ABC transporter; Region: ABC_tran_2; pfam12848 1147128001168 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1147128001169 maltose O-acetyltransferase; Provisional; Region: PRK10092 1147128001170 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1147128001171 active site 1147128001172 substrate binding site [chemical binding]; other site 1147128001173 trimer interface [polypeptide binding]; other site 1147128001174 CoA binding site [chemical binding]; other site 1147128001175 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1147128001176 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1147128001177 putative valine binding site [chemical binding]; other site 1147128001178 dimer interface [polypeptide binding]; other site 1147128001179 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1147128001180 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 1147128001181 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1147128001182 PYR/PP interface [polypeptide binding]; other site 1147128001183 dimer interface [polypeptide binding]; other site 1147128001184 TPP binding site [chemical binding]; other site 1147128001185 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1147128001186 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1147128001187 TPP-binding site [chemical binding]; other site 1147128001188 dimer interface [polypeptide binding]; other site 1147128001189 ribonuclease III; Reviewed; Region: rnc; PRK00102 1147128001190 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1147128001191 dimerization interface [polypeptide binding]; other site 1147128001192 active site 1147128001193 metal binding site [ion binding]; metal-binding site 1147128001194 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1147128001195 dsRNA binding site [nucleotide binding]; other site 1147128001196 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1147128001197 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 1147128001198 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1147128001199 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1147128001200 active site 1147128001201 (T/H)XGH motif; other site 1147128001202 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 1147128001203 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1147128001204 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1147128001205 active site 1147128001206 catalytic tetrad [active] 1147128001207 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1147128001208 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1147128001209 active site 1147128001210 ribonuclease PH; Reviewed; Region: rph; PRK00173 1147128001211 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1147128001212 hexamer interface [polypeptide binding]; other site 1147128001213 active site 1147128001214 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1147128001215 active site 1147128001216 dimerization interface [polypeptide binding]; other site 1147128001217 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1147128001218 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1147128001219 Substrate binding site; other site 1147128001220 Cupin domain; Region: Cupin_2; cl17218 1147128001221 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1147128001222 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1147128001223 active site 1147128001224 dimer interface [polypeptide binding]; other site 1147128001225 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1147128001226 dimer interface [polypeptide binding]; other site 1147128001227 active site 1147128001228 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1147128001229 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1147128001230 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1147128001231 Catalytic site [active] 1147128001232 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1147128001233 RNA/DNA hybrid binding site [nucleotide binding]; other site 1147128001234 active site 1147128001235 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128001236 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128001237 DNA binding site [nucleotide binding] 1147128001238 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1147128001239 ligand binding site [chemical binding]; other site 1147128001240 dimerization interface (open form) [polypeptide binding]; other site 1147128001241 dimerization interface (closed form) [polypeptide binding]; other site 1147128001242 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 1147128001243 putative N- and C-terminal domain interface [polypeptide binding]; other site 1147128001244 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1147128001245 putative active site [active] 1147128001246 MgATP binding site [chemical binding]; other site 1147128001247 catalytic site [active] 1147128001248 metal binding site [ion binding]; metal-binding site 1147128001249 putative carbohydrate binding site [chemical binding]; other site 1147128001250 L-arabinose isomerase; Provisional; Region: PRK02929 1147128001251 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1147128001252 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1147128001253 trimer interface [polypeptide binding]; other site 1147128001254 substrate binding site [chemical binding]; other site 1147128001255 Mn binding site [ion binding]; other site 1147128001256 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 1147128001257 intersubunit interface [polypeptide binding]; other site 1147128001258 active site 1147128001259 Zn2+ binding site [ion binding]; other site 1147128001260 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 1147128001261 active site 1147128001262 catalytic site [active] 1147128001263 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1147128001264 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1147128001265 active site 1147128001266 catalytic tetrad [active] 1147128001267 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1147128001268 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128001269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001270 putative substrate translocation pore; other site 1147128001271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001272 PBP superfamily domain; Region: PBP_like_2; cl17296 1147128001273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128001274 dimer interface [polypeptide binding]; other site 1147128001275 conserved gate region; other site 1147128001276 putative PBP binding loops; other site 1147128001277 ABC-ATPase subunit interface; other site 1147128001278 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 1147128001279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128001280 dimer interface [polypeptide binding]; other site 1147128001281 conserved gate region; other site 1147128001282 putative PBP binding loops; other site 1147128001283 ABC-ATPase subunit interface; other site 1147128001284 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 1147128001285 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1147128001286 Walker A/P-loop; other site 1147128001287 ATP binding site [chemical binding]; other site 1147128001288 Q-loop/lid; other site 1147128001289 ABC transporter signature motif; other site 1147128001290 Walker B; other site 1147128001291 D-loop; other site 1147128001292 H-loop/switch region; other site 1147128001293 Predicted permeases [General function prediction only]; Region: COG0679 1147128001294 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1147128001295 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1147128001296 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001297 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001298 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001299 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001300 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001301 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001302 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001303 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001304 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001305 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001306 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001307 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001308 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001309 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001310 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001311 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001312 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001313 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001314 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001315 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001316 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1147128001317 G5 domain; Region: G5; pfam07501 1147128001318 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1147128001319 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1147128001320 catalytic residue [active] 1147128001321 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1147128001322 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1147128001323 catalytic residues [active] 1147128001324 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1147128001325 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 1147128001326 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1147128001327 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1147128001328 putative NADH binding site [chemical binding]; other site 1147128001329 putative active site [active] 1147128001330 nudix motif; other site 1147128001331 putative metal binding site [ion binding]; other site 1147128001332 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 1147128001333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1147128001334 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1147128001335 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1147128001336 lipoyl attachment site [posttranslational modification]; other site 1147128001337 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1147128001338 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1147128001339 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 1147128001340 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1147128001341 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 1147128001342 tartrate dehydrogenase; Region: TTC; TIGR02089 1147128001343 TM2 domain; Region: TM2; pfam05154 1147128001344 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1147128001345 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1147128001346 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1147128001347 ligand binding site [chemical binding]; other site 1147128001348 flexible hinge region; other site 1147128001349 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1147128001350 putative switch regulator; other site 1147128001351 non-specific DNA interactions [nucleotide binding]; other site 1147128001352 DNA binding site [nucleotide binding] 1147128001353 sequence specific DNA binding site [nucleotide binding]; other site 1147128001354 putative cAMP binding site [chemical binding]; other site 1147128001355 Transglycosylase; Region: Transgly; pfam00912 1147128001356 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1147128001357 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1147128001358 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1147128001359 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 1147128001360 active site 1147128001361 FMN binding site [chemical binding]; other site 1147128001362 substrate binding site [chemical binding]; other site 1147128001363 homotetramer interface [polypeptide binding]; other site 1147128001364 catalytic residue [active] 1147128001365 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 1147128001366 Ligand binding site; other site 1147128001367 Putative Catalytic site; other site 1147128001368 DXD motif; other site 1147128001369 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1147128001370 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1147128001371 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1147128001372 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 1147128001373 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1147128001374 dimer interface [polypeptide binding]; other site 1147128001375 active site 1147128001376 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1147128001377 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1147128001378 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1147128001379 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1147128001380 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1147128001381 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1147128001382 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1147128001383 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1147128001384 minor groove reading motif; other site 1147128001385 helix-hairpin-helix signature motif; other site 1147128001386 active site 1147128001387 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1147128001388 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1147128001389 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1147128001390 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1147128001391 RPB1 interaction site [polypeptide binding]; other site 1147128001392 RPB10 interaction site [polypeptide binding]; other site 1147128001393 RPB11 interaction site [polypeptide binding]; other site 1147128001394 RPB3 interaction site [polypeptide binding]; other site 1147128001395 RPB12 interaction site [polypeptide binding]; other site 1147128001396 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1147128001397 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1147128001398 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1147128001399 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1147128001400 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1147128001401 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1147128001402 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1147128001403 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1147128001404 DNA binding site [nucleotide binding] 1147128001405 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1147128001406 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1147128001407 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1147128001408 Protein of unknown function DUF58; Region: DUF58; pfam01882 1147128001409 MoxR-like ATPases [General function prediction only]; Region: COG0714 1147128001410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128001411 Walker A motif; other site 1147128001412 ATP binding site [chemical binding]; other site 1147128001413 Walker B motif; other site 1147128001414 arginine finger; other site 1147128001415 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1147128001416 Interdomain contacts; other site 1147128001417 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1147128001418 Protein kinase domain; Region: Pkinase; pfam00069 1147128001419 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1147128001420 active site 1147128001421 ATP binding site [chemical binding]; other site 1147128001422 substrate binding site [chemical binding]; other site 1147128001423 activation loop (A-loop); other site 1147128001424 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1147128001425 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1147128001426 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 1147128001427 Part of AAA domain; Region: AAA_19; pfam13245 1147128001428 Family description; Region: UvrD_C_2; pfam13538 1147128001429 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1147128001430 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128001431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 1147128001432 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1147128001433 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1147128001434 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1147128001435 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1147128001436 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1147128001437 dimer interface [polypeptide binding]; other site 1147128001438 active site 1147128001439 catalytic residue [active] 1147128001440 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1147128001441 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1147128001442 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1147128001443 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1147128001444 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1147128001445 NAD(P) binding site [chemical binding]; other site 1147128001446 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1147128001447 nucleophilic elbow; other site 1147128001448 catalytic triad; other site 1147128001449 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 1147128001450 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 1147128001451 Zn binding site [ion binding]; other site 1147128001452 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 1147128001453 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1147128001454 active site 1147128001455 substrate binding site [chemical binding]; other site 1147128001456 metal binding site [ion binding]; metal-binding site 1147128001457 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1147128001458 active site 1147128001459 catalytic residues [active] 1147128001460 metal binding site [ion binding]; metal-binding site 1147128001461 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 1147128001462 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1147128001463 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1147128001464 NAD binding site [chemical binding]; other site 1147128001465 catalytic Zn binding site [ion binding]; other site 1147128001466 substrate binding site [chemical binding]; other site 1147128001467 structural Zn binding site [ion binding]; other site 1147128001468 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1147128001469 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 1147128001470 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1147128001471 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1147128001472 substrate binding pocket [chemical binding]; other site 1147128001473 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1147128001474 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001475 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1147128001476 active site 1147128001477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001478 putative substrate translocation pore; other site 1147128001479 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128001480 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001481 putative substrate translocation pore; other site 1147128001482 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001483 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001484 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001485 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001486 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001487 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001488 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001489 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001490 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001491 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001492 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001493 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001494 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001495 IPT/TIG domain; Region: TIG; pfam01833 1147128001496 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001497 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001498 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001499 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001500 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001501 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001502 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001503 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001504 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001505 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001506 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001507 Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor...; Region: IPT; cl15674 1147128001508 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001509 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001510 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001511 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001512 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001513 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001514 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001515 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001516 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001517 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001518 IPT/TIG domain; Region: TIG; pfam01833 1147128001519 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001520 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1147128001521 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1147128001522 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001523 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001524 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001525 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001526 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001527 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001528 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001529 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001530 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001531 IPT/TIG domain; Region: TIG; pfam01833 1147128001532 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001533 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001534 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001535 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001536 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001537 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001538 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001539 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001540 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001541 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001542 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001543 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001544 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128001545 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128001546 DNA binding site [nucleotide binding] 1147128001547 domain linker motif; other site 1147128001548 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128001549 ligand binding site [chemical binding]; other site 1147128001550 dimerization interface [polypeptide binding]; other site 1147128001551 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 1147128001552 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 1147128001553 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001554 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001555 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001556 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001557 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001558 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001559 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001560 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001561 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001562 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001563 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001564 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001565 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001566 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001567 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001568 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001569 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001570 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001571 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001572 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001573 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001574 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001575 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001576 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001577 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001578 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001579 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001580 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001581 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001582 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001583 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001584 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001585 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001586 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001587 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001588 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001589 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001590 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001591 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001592 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001593 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001594 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001595 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001596 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001597 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001598 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001599 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001600 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001601 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001602 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001603 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001604 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001605 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001606 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001607 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001608 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001609 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001610 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001611 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1147128001612 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 1147128001613 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1147128001614 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1147128001615 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128001616 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1147128001617 Walker A/P-loop; other site 1147128001618 ATP binding site [chemical binding]; other site 1147128001619 Q-loop/lid; other site 1147128001620 ABC transporter signature motif; other site 1147128001621 Walker B; other site 1147128001622 D-loop; other site 1147128001623 H-loop/switch region; other site 1147128001624 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001625 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001626 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001627 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001628 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001629 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001630 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001631 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128001632 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001633 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001634 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001635 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001636 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001637 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001638 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128001639 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128001640 Predicted transcriptional regulators [Transcription]; Region: COG1733 1147128001641 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1147128001642 dimerization interface [polypeptide binding]; other site 1147128001643 putative DNA binding site [nucleotide binding]; other site 1147128001644 putative Zn2+ binding site [ion binding]; other site 1147128001645 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 1147128001646 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1147128001647 NAD binding site [chemical binding]; other site 1147128001648 substrate binding site [chemical binding]; other site 1147128001649 putative active site [active] 1147128001650 Protein of unknown function (DUF4065); Region: DUF4065; cl01445 1147128001651 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1147128001652 MarR family; Region: MarR_2; pfam12802 1147128001653 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1147128001654 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1147128001655 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1147128001656 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1147128001657 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1147128001658 S-adenosylmethionine binding site [chemical binding]; other site 1147128001659 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1147128001660 putative catalytic site [active] 1147128001661 putative metal binding site [ion binding]; other site 1147128001662 putative phosphate binding site [ion binding]; other site 1147128001663 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1147128001664 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1147128001665 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1147128001666 generic binding surface II; other site 1147128001667 generic binding surface I; other site 1147128001668 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1147128001669 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1147128001670 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 1147128001671 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 1147128001672 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1147128001673 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 1147128001674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 1147128001675 maltose O-acetyltransferase; Provisional; Region: PRK10092 1147128001676 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1147128001677 active site 1147128001678 substrate binding site [chemical binding]; other site 1147128001679 trimer interface [polypeptide binding]; other site 1147128001680 CoA binding site [chemical binding]; other site 1147128001681 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1147128001682 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1147128001683 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001684 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128001685 putative substrate translocation pore; other site 1147128001686 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1147128001687 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1147128001688 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1147128001689 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1147128001690 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1147128001691 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1147128001692 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1147128001693 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1147128001694 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 1147128001695 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1147128001696 HIGH motif; other site 1147128001697 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1147128001698 active site 1147128001699 KMSKS motif; other site 1147128001700 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 1147128001701 tRNA binding surface [nucleotide binding]; other site 1147128001702 anticodon binding site; other site 1147128001703 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1147128001704 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1147128001705 active site 1147128001706 catalytic tetrad [active] 1147128001707 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1147128001708 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1147128001709 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1147128001710 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1147128001711 active site 1147128001712 nucleophile elbow; other site 1147128001713 glutamate racemase; Provisional; Region: PRK00865 1147128001714 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1147128001715 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1147128001716 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1147128001717 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 1147128001718 putative active site [active] 1147128001719 redox center [active] 1147128001720 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1147128001721 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1147128001722 active site 1147128001723 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1147128001724 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 1147128001725 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1147128001726 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 1147128001727 Part of AAA domain; Region: AAA_19; pfam13245 1147128001728 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1147128001729 Family description; Region: UvrD_C_2; pfam13538 1147128001730 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 1147128001731 uncharacterized protein, coenzyme F420 biosynthesis associated; Region: DUF2342_F420; TIGR03883 1147128001732 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1147128001733 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 1147128001734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001735 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128001736 putative substrate translocation pore; other site 1147128001737 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001738 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 1147128001739 DivIVA domain; Region: DivI1A_domain; TIGR03544 1147128001740 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1147128001741 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1147128001742 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1147128001743 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1147128001744 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1147128001745 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1147128001746 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1147128001747 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1147128001748 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1147128001749 Recombination protein O N terminal; Region: RecO_N; pfam11967 1147128001750 Recombination protein O C terminal; Region: RecO_C; pfam02565 1147128001751 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 1147128001752 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1147128001753 catalytic residue [active] 1147128001754 putative FPP diphosphate binding site; other site 1147128001755 putative FPP binding hydrophobic cleft; other site 1147128001756 dimer interface [polypeptide binding]; other site 1147128001757 putative IPP diphosphate binding site; other site 1147128001758 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1147128001759 amidohydrolase; Region: amidohydrolases; TIGR01891 1147128001760 putative metal binding site [ion binding]; other site 1147128001761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001762 D-galactonate transporter; Region: 2A0114; TIGR00893 1147128001763 putative substrate translocation pore; other site 1147128001764 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1147128001765 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1147128001766 substrate binding [chemical binding]; other site 1147128001767 active site 1147128001768 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1147128001769 galactoside permease; Reviewed; Region: lacY; PRK09528 1147128001770 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128001771 putative substrate translocation pore; other site 1147128001772 Domain of unknown function DUF77; Region: DUF77; pfam01910 1147128001773 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1147128001774 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1147128001775 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1147128001776 active site 1147128001777 motif 2; other site 1147128001778 motif 3; other site 1147128001779 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1147128001780 anticodon binding site; other site 1147128001781 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1147128001782 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1147128001783 FMN binding site [chemical binding]; other site 1147128001784 active site 1147128001785 catalytic residues [active] 1147128001786 substrate binding site [chemical binding]; other site 1147128001787 cell division protein FtsZ; Validated; Region: PRK09330 1147128001788 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1147128001789 nucleotide binding site [chemical binding]; other site 1147128001790 SulA interaction site; other site 1147128001791 Protein of unknown function (DUF552); Region: DUF552; pfam04472 1147128001792 YGGT family; Region: YGGT; pfam02325 1147128001793 DivIVA protein; Region: DivIVA; pfam05103 1147128001794 DivIVA domain; Region: DivI1A_domain; TIGR03544 1147128001795 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 1147128001796 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1147128001797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1147128001798 RNA binding surface [nucleotide binding]; other site 1147128001799 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1147128001800 active site 1147128001801 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1147128001802 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1147128001803 active site 1147128001804 PHP Thumb interface [polypeptide binding]; other site 1147128001805 metal binding site [ion binding]; metal-binding site 1147128001806 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1147128001807 generic binding surface II; other site 1147128001808 generic binding surface I; other site 1147128001809 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 1147128001810 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1147128001811 NAD binding site [chemical binding]; other site 1147128001812 dimerization interface [polypeptide binding]; other site 1147128001813 product binding site; other site 1147128001814 substrate binding site [chemical binding]; other site 1147128001815 zinc binding site [ion binding]; other site 1147128001816 catalytic residues [active] 1147128001817 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 1147128001818 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1147128001819 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128001820 homodimer interface [polypeptide binding]; other site 1147128001821 catalytic residue [active] 1147128001822 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1147128001823 putative active site pocket [active] 1147128001824 4-fold oligomerization interface [polypeptide binding]; other site 1147128001825 metal binding residues [ion binding]; metal-binding site 1147128001826 3-fold/trimer interface [polypeptide binding]; other site 1147128001827 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 1147128001828 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1147128001829 putative active site [active] 1147128001830 oxyanion strand; other site 1147128001831 catalytic triad [active] 1147128001832 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1147128001833 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1147128001834 catalytic residues [active] 1147128001835 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1147128001836 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1147128001837 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1147128001838 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128001839 putative Mg++ binding site [ion binding]; other site 1147128001840 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128001841 nucleotide binding region [chemical binding]; other site 1147128001842 ATP-binding site [chemical binding]; other site 1147128001843 Helicase associated domain (HA2); Region: HA2; pfam04408 1147128001844 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1147128001845 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1147128001846 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1147128001847 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1147128001848 S-adenosylmethionine binding site [chemical binding]; other site 1147128001849 GTPases [General function prediction only]; Region: HflX; COG2262 1147128001850 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1147128001851 HflX GTPase family; Region: HflX; cd01878 1147128001852 G1 box; other site 1147128001853 GTP/Mg2+ binding site [chemical binding]; other site 1147128001854 Switch I region; other site 1147128001855 G2 box; other site 1147128001856 G3 box; other site 1147128001857 Switch II region; other site 1147128001858 G4 box; other site 1147128001859 G5 box; other site 1147128001860 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 1147128001861 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 1147128001862 NAD binding site [chemical binding]; other site 1147128001863 dimer interface [polypeptide binding]; other site 1147128001864 substrate binding site [chemical binding]; other site 1147128001865 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1147128001866 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1147128001867 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1147128001868 LexA repressor; Validated; Region: PRK00215 1147128001869 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1147128001870 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1147128001871 Catalytic site [active] 1147128001872 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1147128001873 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1147128001874 ATP cone domain; Region: ATP-cone; pfam03477 1147128001875 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 1147128001876 Part of AAA domain; Region: AAA_19; pfam13245 1147128001877 Family description; Region: UvrD_C_2; pfam13538 1147128001878 cell division protein MraZ; Reviewed; Region: PRK00326 1147128001879 MraZ protein; Region: MraZ; pfam02381 1147128001880 MraZ protein; Region: MraZ; pfam02381 1147128001881 MraW methylase family; Region: Methyltransf_5; cl17771 1147128001882 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1147128001883 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1147128001884 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1147128001885 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1147128001886 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 1147128001887 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1147128001888 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1147128001889 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1147128001890 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1147128001891 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1147128001892 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1147128001893 Mg++ binding site [ion binding]; other site 1147128001894 putative catalytic motif [active] 1147128001895 putative substrate binding site [chemical binding]; other site 1147128001896 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 1147128001897 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1147128001898 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1147128001899 cell division protein FtsW; Region: ftsW; TIGR02614 1147128001900 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1147128001901 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1147128001902 active site 1147128001903 homodimer interface [polypeptide binding]; other site 1147128001904 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1147128001905 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1147128001906 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1147128001907 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1147128001908 cell division protein FtsQ; Provisional; Region: PRK05529 1147128001909 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1147128001910 Cell division protein FtsQ; Region: FtsQ; pfam03799 1147128001911 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1147128001912 putative active site [active] 1147128001913 dimerization interface [polypeptide binding]; other site 1147128001914 putative tRNAtyr binding site [nucleotide binding]; other site 1147128001915 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1147128001916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1147128001917 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1147128001918 Coenzyme A binding pocket [chemical binding]; other site 1147128001919 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 1147128001920 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1147128001921 RelB antitoxin; Region: RelB; cl01171 1147128001922 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1147128001923 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1147128001924 putative DNA binding site [nucleotide binding]; other site 1147128001925 putative Zn2+ binding site [ion binding]; other site 1147128001926 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1147128001927 dimerization interface [polypeptide binding]; other site 1147128001928 malate dehydrogenase; Provisional; Region: PRK13529 1147128001929 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1147128001930 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1147128001931 NAD(P) binding pocket [chemical binding]; other site 1147128001932 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1147128001933 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1147128001934 transmembrane helices; other site 1147128001935 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1147128001936 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1147128001937 putative substrate binding site [chemical binding]; other site 1147128001938 putative ATP binding site [chemical binding]; other site 1147128001939 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1147128001940 dimerization interface [polypeptide binding]; other site 1147128001941 putative DNA binding site [nucleotide binding]; other site 1147128001942 putative Zn2+ binding site [ion binding]; other site 1147128001943 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1147128001944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1147128001945 nucleotide binding site [chemical binding]; other site 1147128001946 xylose isomerase; Provisional; Region: PRK05474 1147128001947 xylose isomerase; Region: xylose_isom_A; TIGR02630 1147128001948 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1147128001949 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1147128001950 substrate binding site [chemical binding]; other site 1147128001951 ATP binding site [chemical binding]; other site 1147128001952 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1147128001953 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1147128001954 putative DNA binding site [nucleotide binding]; other site 1147128001955 putative Zn2+ binding site [ion binding]; other site 1147128001956 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1147128001957 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1147128001958 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1147128001959 NAD binding site [chemical binding]; other site 1147128001960 sugar binding site [chemical binding]; other site 1147128001961 divalent metal binding site [ion binding]; other site 1147128001962 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1147128001963 dimer interface [polypeptide binding]; other site 1147128001964 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1147128001965 active site 1147128001966 catalytic site [active] 1147128001967 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1147128001968 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1147128001969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128001970 dimer interface [polypeptide binding]; other site 1147128001971 conserved gate region; other site 1147128001972 putative PBP binding loops; other site 1147128001973 ABC-ATPase subunit interface; other site 1147128001974 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128001975 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128001976 dimer interface [polypeptide binding]; other site 1147128001977 conserved gate region; other site 1147128001978 putative PBP binding loops; other site 1147128001979 ABC-ATPase subunit interface; other site 1147128001980 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128001981 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128001982 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1147128001983 active site 1147128001984 catalytic site [active] 1147128001985 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1147128001986 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 1147128001987 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128001988 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128001989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128001990 dimer interface [polypeptide binding]; other site 1147128001991 conserved gate region; other site 1147128001992 putative PBP binding loops; other site 1147128001993 ABC-ATPase subunit interface; other site 1147128001994 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128001995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128001996 dimer interface [polypeptide binding]; other site 1147128001997 conserved gate region; other site 1147128001998 putative PBP binding loops; other site 1147128001999 ABC-ATPase subunit interface; other site 1147128002000 Alpha-amylase domain; Region: Aamy; smart00642 1147128002001 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128002002 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128002003 DNA binding site [nucleotide binding] 1147128002004 domain linker motif; other site 1147128002005 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128002006 ligand binding site [chemical binding]; other site 1147128002007 dimerization interface [polypeptide binding]; other site 1147128002008 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1147128002009 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1147128002010 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1147128002011 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1147128002012 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 1147128002013 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1147128002014 D-xylulose kinase; Region: XylB; TIGR01312 1147128002015 nucleotide binding site [chemical binding]; other site 1147128002016 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1147128002017 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1147128002018 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1147128002019 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 1147128002020 nudix motif; other site 1147128002021 proline aminopeptidase P II; Provisional; Region: PRK10879 1147128002022 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 1147128002023 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1147128002024 active site 1147128002025 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1147128002026 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1147128002027 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1147128002028 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1147128002029 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1147128002030 Walker A/P-loop; other site 1147128002031 ATP binding site [chemical binding]; other site 1147128002032 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1147128002033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128002034 ABC transporter signature motif; other site 1147128002035 Walker B; other site 1147128002036 D-loop; other site 1147128002037 H-loop/switch region; other site 1147128002038 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1147128002039 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1147128002040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1147128002041 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1147128002042 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1147128002043 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1147128002044 active site 1147128002045 catalytic site [active] 1147128002046 substrate binding site [chemical binding]; other site 1147128002047 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 1147128002048 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1147128002049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1147128002050 DNA binding residues [nucleotide binding] 1147128002051 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1147128002052 active site 1147128002053 catalytic residues [active] 1147128002054 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1147128002055 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1147128002056 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1147128002057 putative deacylase active site [active] 1147128002058 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1147128002059 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 1147128002060 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1147128002061 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1147128002062 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1147128002063 ArsC family; Region: ArsC; pfam03960 1147128002064 putative ArsC-like catalytic residues; other site 1147128002065 putative TRX-like catalytic residues [active] 1147128002066 Thiamine pyrophosphokinase; Region: TPK; cd07995 1147128002067 active site 1147128002068 dimerization interface [polypeptide binding]; other site 1147128002069 thiamine binding site [chemical binding]; other site 1147128002070 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 1147128002071 AzlC protein; Region: AzlC; cl00570 1147128002072 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 1147128002073 SelR domain; Region: SelR; pfam01641 1147128002074 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1147128002075 translation initiation factor IF-3; Region: infC; TIGR00168 1147128002076 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1147128002077 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1147128002078 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1147128002079 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1147128002080 23S rRNA binding site [nucleotide binding]; other site 1147128002081 L21 binding site [polypeptide binding]; other site 1147128002082 L13 binding site [polypeptide binding]; other site 1147128002083 Predicted spermidine synthase with an N-terminal membrane domain [General function prediction only]; Region: COG4262 1147128002084 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1147128002085 S-adenosylmethionine binding site [chemical binding]; other site 1147128002086 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1147128002087 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1147128002088 active site 1147128002089 Int/Topo IB signature motif; other site 1147128002090 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1147128002091 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1147128002092 P-loop; other site 1147128002093 Magnesium ion binding site [ion binding]; other site 1147128002094 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1147128002095 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1147128002096 Magnesium ion binding site [ion binding]; other site 1147128002097 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 1147128002098 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1147128002099 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1147128002100 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 1147128002101 G1 box; other site 1147128002102 putative GEF interaction site [polypeptide binding]; other site 1147128002103 GTP/Mg2+ binding site [chemical binding]; other site 1147128002104 Switch I region; other site 1147128002105 G2 box; other site 1147128002106 G3 box; other site 1147128002107 Switch II region; other site 1147128002108 G4 box; other site 1147128002109 G5 box; other site 1147128002110 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1147128002111 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1147128002112 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1147128002113 Prephenate dehydratase; Region: PDT; pfam00800 1147128002114 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1147128002115 putative L-Phe binding site [chemical binding]; other site 1147128002116 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1147128002117 prephenate dehydrogenase; Validated; Region: PRK08507 1147128002118 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1147128002119 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1147128002120 active site 1147128002121 DNA binding site [nucleotide binding] 1147128002122 Int/Topo IB signature motif; other site 1147128002123 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1147128002124 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1147128002125 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1147128002126 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1147128002127 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1147128002128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128002129 dimer interface [polypeptide binding]; other site 1147128002130 conserved gate region; other site 1147128002131 putative PBP binding loops; other site 1147128002132 ABC-ATPase subunit interface; other site 1147128002133 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1147128002134 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1147128002135 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128002136 dimer interface [polypeptide binding]; other site 1147128002137 conserved gate region; other site 1147128002138 putative PBP binding loops; other site 1147128002139 ABC-ATPase subunit interface; other site 1147128002140 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1147128002141 AAA domain; Region: AAA_21; pfam13304 1147128002142 Walker A/P-loop; other site 1147128002143 ATP binding site [chemical binding]; other site 1147128002144 Q-loop/lid; other site 1147128002145 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1147128002146 ABC transporter signature motif; other site 1147128002147 Walker B; other site 1147128002148 D-loop; other site 1147128002149 H-loop/switch region; other site 1147128002150 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1147128002151 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1147128002152 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1147128002153 Walker A/P-loop; other site 1147128002154 ATP binding site [chemical binding]; other site 1147128002155 Q-loop/lid; other site 1147128002156 ABC transporter signature motif; other site 1147128002157 Walker B; other site 1147128002158 D-loop; other site 1147128002159 H-loop/switch region; other site 1147128002160 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1147128002161 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 1147128002162 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 1147128002163 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1147128002164 TRAM domain; Region: TRAM; pfam01938 1147128002165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1147128002166 S-adenosylmethionine binding site [chemical binding]; other site 1147128002167 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1147128002168 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1147128002169 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1147128002170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1147128002171 motif II; other site 1147128002172 aconitate hydratase; Validated; Region: PRK09277 1147128002173 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1147128002174 substrate binding site [chemical binding]; other site 1147128002175 ligand binding site [chemical binding]; other site 1147128002176 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1147128002177 substrate binding site [chemical binding]; other site 1147128002178 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1147128002179 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1147128002180 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128002181 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1147128002182 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128002183 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128002184 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002185 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002186 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128002187 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002188 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002189 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128002190 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002191 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002192 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128002193 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1147128002194 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128002195 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002196 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002197 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002198 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002199 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002200 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002201 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002202 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1147128002203 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1147128002204 active site 1147128002205 catalytic tetrad [active] 1147128002206 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1147128002207 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1147128002208 synthetase active site [active] 1147128002209 NTP binding site [chemical binding]; other site 1147128002210 metal binding site [ion binding]; metal-binding site 1147128002211 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 1147128002212 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1147128002213 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1147128002214 FeS/SAM binding site; other site 1147128002215 TRAM domain; Region: TRAM; cl01282 1147128002216 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1147128002217 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1147128002218 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1147128002219 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 1147128002220 DNA binding residues [nucleotide binding] 1147128002221 putative dimer interface [polypeptide binding]; other site 1147128002222 Fic/DOC family; Region: Fic; cl00960 1147128002223 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1147128002224 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1147128002225 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 1147128002226 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1147128002227 Competence-damaged protein; Region: CinA; pfam02464 1147128002228 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1147128002229 non-specific DNA binding site [nucleotide binding]; other site 1147128002230 salt bridge; other site 1147128002231 sequence-specific DNA binding site [nucleotide binding]; other site 1147128002232 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 1147128002233 recombinase A; Provisional; Region: recA; PRK09354 1147128002234 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1147128002235 hexamer interface [polypeptide binding]; other site 1147128002236 Walker A motif; other site 1147128002237 ATP binding site [chemical binding]; other site 1147128002238 Walker B motif; other site 1147128002239 RecX family; Region: RecX; pfam02631 1147128002240 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1147128002241 30S subunit binding site; other site 1147128002242 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1147128002243 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1147128002244 ATP binding site [chemical binding]; other site 1147128002245 putative Mg++ binding site [ion binding]; other site 1147128002246 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1147128002247 SEC-C motif; Region: SEC-C; pfam02810 1147128002248 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1147128002249 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1147128002250 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1147128002251 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1147128002252 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1147128002253 putative acyl-acceptor binding pocket; other site 1147128002254 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1147128002255 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1147128002256 active site 1147128002257 ATP binding site [chemical binding]; other site 1147128002258 substrate binding site [chemical binding]; other site 1147128002259 activation loop (A-loop); other site 1147128002260 PASTA domain; Region: PASTA; pfam03793 1147128002261 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1147128002262 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1147128002263 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1147128002264 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1147128002265 substrate binding pocket [chemical binding]; other site 1147128002266 chain length determination region; other site 1147128002267 substrate-Mg2+ binding site; other site 1147128002268 catalytic residues [active] 1147128002269 aspartate-rich region 1; other site 1147128002270 active site lid residues [active] 1147128002271 aspartate-rich region 2; other site 1147128002272 Probable transposase; Region: OrfB_IS605; pfam01385 1147128002273 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 1147128002274 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1147128002275 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1147128002276 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1147128002277 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1147128002278 DNA binding residues [nucleotide binding] 1147128002279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128002280 Mg2+ binding site [ion binding]; other site 1147128002281 G-X-G motif; other site 1147128002282 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1147128002283 anchoring element; other site 1147128002284 dimer interface [polypeptide binding]; other site 1147128002285 ATP binding site [chemical binding]; other site 1147128002286 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1147128002287 active site 1147128002288 metal binding site [ion binding]; metal-binding site 1147128002289 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1147128002290 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128002291 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1147128002292 ATP binding site [chemical binding]; other site 1147128002293 putative Mg++ binding site [ion binding]; other site 1147128002294 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128002295 nucleotide binding region [chemical binding]; other site 1147128002296 ATP-binding site [chemical binding]; other site 1147128002297 DEAD/H associated; Region: DEAD_assoc; pfam08494 1147128002298 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1147128002299 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1147128002300 CAP-like domain; other site 1147128002301 active site 1147128002302 primary dimer interface [polypeptide binding]; other site 1147128002303 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1147128002304 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1147128002305 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 1147128002306 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 1147128002307 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 1147128002308 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1147128002309 trimer interface [polypeptide binding]; other site 1147128002310 active site 1147128002311 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1147128002312 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1147128002313 Zn2+ binding site [ion binding]; other site 1147128002314 Mg2+ binding site [ion binding]; other site 1147128002315 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1147128002316 synthetase active site [active] 1147128002317 NTP binding site [chemical binding]; other site 1147128002318 metal binding site [ion binding]; metal-binding site 1147128002319 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1147128002320 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1147128002321 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1147128002322 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 1147128002323 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1147128002324 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1147128002325 dimer interface [polypeptide binding]; other site 1147128002326 motif 1; other site 1147128002327 active site 1147128002328 motif 2; other site 1147128002329 motif 3; other site 1147128002330 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1147128002331 anticodon binding site; other site 1147128002332 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1147128002333 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1147128002334 dimer interface [polypeptide binding]; other site 1147128002335 anticodon binding site; other site 1147128002336 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1147128002337 motif 1; other site 1147128002338 dimer interface [polypeptide binding]; other site 1147128002339 active site 1147128002340 motif 2; other site 1147128002341 GAD domain; Region: GAD; pfam02938 1147128002342 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1147128002343 active site 1147128002344 motif 3; other site 1147128002345 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1147128002346 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1147128002347 Walker A/P-loop; other site 1147128002348 ATP binding site [chemical binding]; other site 1147128002349 Q-loop/lid; other site 1147128002350 ABC transporter signature motif; other site 1147128002351 Walker B; other site 1147128002352 D-loop; other site 1147128002353 H-loop/switch region; other site 1147128002354 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1147128002355 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1147128002356 substrate binding pocket [chemical binding]; other site 1147128002357 membrane-bound complex binding site; other site 1147128002358 hinge residues; other site 1147128002359 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128002360 dimer interface [polypeptide binding]; other site 1147128002361 conserved gate region; other site 1147128002362 ABC-ATPase subunit interface; other site 1147128002363 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1147128002364 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128002365 dimer interface [polypeptide binding]; other site 1147128002366 conserved gate region; other site 1147128002367 putative PBP binding loops; other site 1147128002368 ABC-ATPase subunit interface; other site 1147128002369 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128002370 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1147128002371 Walker A/P-loop; other site 1147128002372 ATP binding site [chemical binding]; other site 1147128002373 Q-loop/lid; other site 1147128002374 ABC transporter signature motif; other site 1147128002375 Walker B; other site 1147128002376 D-loop; other site 1147128002377 H-loop/switch region; other site 1147128002378 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128002379 ATP binding site [chemical binding]; other site 1147128002380 putative Mg++ binding site [ion binding]; other site 1147128002381 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128002382 nucleotide binding region [chemical binding]; other site 1147128002383 ATP-binding site [chemical binding]; other site 1147128002384 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 1147128002385 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1147128002386 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1147128002387 Walker A/P-loop; other site 1147128002388 ATP binding site [chemical binding]; other site 1147128002389 Q-loop/lid; other site 1147128002390 ABC transporter signature motif; other site 1147128002391 Walker B; other site 1147128002392 D-loop; other site 1147128002393 H-loop/switch region; other site 1147128002394 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1147128002395 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1147128002396 substrate binding pocket [chemical binding]; other site 1147128002397 membrane-bound complex binding site; other site 1147128002398 hinge residues; other site 1147128002399 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1147128002400 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128002401 dimer interface [polypeptide binding]; other site 1147128002402 conserved gate region; other site 1147128002403 putative PBP binding loops; other site 1147128002404 ABC-ATPase subunit interface; other site 1147128002405 recombination factor protein RarA; Reviewed; Region: PRK13342 1147128002406 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128002407 Walker A motif; other site 1147128002408 ATP binding site [chemical binding]; other site 1147128002409 Walker B motif; other site 1147128002410 arginine finger; other site 1147128002411 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1147128002412 benzoate transport; Region: 2A0115; TIGR00895 1147128002413 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128002414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128002415 putative substrate translocation pore; other site 1147128002416 MarR family; Region: MarR_2; pfam12802 1147128002417 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1147128002418 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1147128002419 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1147128002420 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1147128002421 additional DNA contacts [nucleotide binding]; other site 1147128002422 mismatch recognition site; other site 1147128002423 active site 1147128002424 zinc binding site [ion binding]; other site 1147128002425 DNA intercalation site [nucleotide binding]; other site 1147128002426 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1147128002427 active site 1147128002428 hypothetical protein; Provisional; Region: PRK11770 1147128002429 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1147128002430 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1147128002431 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1147128002432 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1147128002433 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128002434 putative substrate translocation pore; other site 1147128002435 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128002436 NAD synthetase; Provisional; Region: PRK13981 1147128002437 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1147128002438 multimer interface [polypeptide binding]; other site 1147128002439 active site 1147128002440 catalytic triad [active] 1147128002441 protein interface 1 [polypeptide binding]; other site 1147128002442 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1147128002443 homodimer interface [polypeptide binding]; other site 1147128002444 NAD binding pocket [chemical binding]; other site 1147128002445 ATP binding pocket [chemical binding]; other site 1147128002446 Mg binding site [ion binding]; other site 1147128002447 active-site loop [active] 1147128002448 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1147128002449 Pyruvate formate lyase 1; Region: PFL1; cd01678 1147128002450 coenzyme A binding site [chemical binding]; other site 1147128002451 active site 1147128002452 catalytic residues [active] 1147128002453 glycine loop; other site 1147128002454 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1147128002455 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1147128002456 FeS/SAM binding site; other site 1147128002457 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1147128002458 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 1147128002459 catalytic site [active] 1147128002460 putative active site [active] 1147128002461 putative substrate binding site [chemical binding]; other site 1147128002462 HRDC domain; Region: HRDC; pfam00570 1147128002463 trigger factor; Provisional; Region: tig; PRK01490 1147128002464 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1147128002465 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1147128002466 Clp protease; Region: CLP_protease; pfam00574 1147128002467 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1147128002468 oligomer interface [polypeptide binding]; other site 1147128002469 active site residues [active] 1147128002470 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 1147128002471 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1147128002472 oligomer interface [polypeptide binding]; other site 1147128002473 active site residues [active] 1147128002474 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1147128002475 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1147128002476 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128002477 Walker A motif; other site 1147128002478 ATP binding site [chemical binding]; other site 1147128002479 Walker B motif; other site 1147128002480 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1147128002481 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 1147128002482 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1147128002483 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1147128002484 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1147128002485 Walker A/P-loop; other site 1147128002486 ATP binding site [chemical binding]; other site 1147128002487 Q-loop/lid; other site 1147128002488 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1147128002489 ABC transporter signature motif; other site 1147128002490 Walker B; other site 1147128002491 D-loop; other site 1147128002492 H-loop/switch region; other site 1147128002493 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1147128002494 DNA-binding site [nucleotide binding]; DNA binding site 1147128002495 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128002496 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1147128002497 Walker A/P-loop; other site 1147128002498 ATP binding site [chemical binding]; other site 1147128002499 Q-loop/lid; other site 1147128002500 ABC transporter signature motif; other site 1147128002501 Walker B; other site 1147128002502 D-loop; other site 1147128002503 H-loop/switch region; other site 1147128002504 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1147128002505 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1147128002506 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128002507 catalytic residue [active] 1147128002508 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1147128002509 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1147128002510 dimer interface [polypeptide binding]; other site 1147128002511 active site 1147128002512 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1147128002513 folate binding site [chemical binding]; other site 1147128002514 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1147128002515 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1147128002516 putative catalytic cysteine [active] 1147128002517 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1147128002518 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1147128002519 active site 1147128002520 (T/H)XGH motif; other site 1147128002521 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1147128002522 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 1147128002523 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1147128002524 active site 1147128002525 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1147128002526 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1147128002527 active site 1147128002528 motif I; other site 1147128002529 motif II; other site 1147128002530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1147128002531 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 1147128002532 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1147128002533 Substrate binding site; other site 1147128002534 Mg++ binding site; other site 1147128002535 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1147128002536 active site 1147128002537 substrate binding site [chemical binding]; other site 1147128002538 CoA binding site [chemical binding]; other site 1147128002539 Oligomerisation domain; Region: Oligomerisation; pfam02410 1147128002540 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1147128002541 catalytic core [active] 1147128002542 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1147128002543 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1147128002544 dimer interface [polypeptide binding]; other site 1147128002545 active site 1147128002546 metal binding site [ion binding]; metal-binding site 1147128002547 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1147128002548 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1147128002549 substrate binding site [chemical binding]; other site 1147128002550 ATP binding site [chemical binding]; other site 1147128002551 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1147128002552 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1147128002553 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1147128002554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1147128002555 MULE transposase domain; Region: MULE; pfam10551 1147128002556 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1147128002557 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1147128002558 NAD binding site [chemical binding]; other site 1147128002559 ligand binding site [chemical binding]; other site 1147128002560 catalytic site [active] 1147128002561 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 1147128002562 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1147128002563 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1147128002564 Cl binding site [ion binding]; other site 1147128002565 oligomer interface [polypeptide binding]; other site 1147128002566 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1147128002567 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1147128002568 substrate binding pocket [chemical binding]; other site 1147128002569 membrane-bound complex binding site; other site 1147128002570 hinge residues; other site 1147128002571 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1147128002572 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1147128002573 active site 1147128002574 HIGH motif; other site 1147128002575 nucleotide binding site [chemical binding]; other site 1147128002576 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1147128002577 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1147128002578 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1147128002579 active site 1147128002580 KMSKS motif; other site 1147128002581 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1147128002582 tRNA binding surface [nucleotide binding]; other site 1147128002583 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1147128002584 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1147128002585 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 1147128002586 Competence protein; Region: Competence; pfam03772 1147128002587 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1147128002588 hypothetical protein; Reviewed; Region: PRK07914 1147128002589 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1147128002590 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1147128002591 Glycoprotease family; Region: Peptidase_M22; pfam00814 1147128002592 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1147128002593 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1147128002594 Coenzyme A binding pocket [chemical binding]; other site 1147128002595 UGMP family protein; Validated; Region: PRK09604 1147128002596 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1147128002597 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1147128002598 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1147128002599 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1147128002600 Peptidase family M23; Region: Peptidase_M23; pfam01551 1147128002601 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1147128002602 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1147128002603 acyl-activating enzyme (AAE) consensus motif; other site 1147128002604 putative AMP binding site [chemical binding]; other site 1147128002605 putative active site [active] 1147128002606 putative CoA binding site [chemical binding]; other site 1147128002607 isocitrate dehydrogenase; Validated; Region: PRK08299 1147128002608 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 1147128002609 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1147128002610 phosphate binding site [ion binding]; other site 1147128002611 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1147128002612 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1147128002613 acyl-activating enzyme (AAE) consensus motif; other site 1147128002614 putative AMP binding site [chemical binding]; other site 1147128002615 putative active site [active] 1147128002616 putative CoA binding site [chemical binding]; other site 1147128002617 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1147128002618 active site 1147128002619 catalytic residues [active] 1147128002620 metal binding site [ion binding]; metal-binding site 1147128002621 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1147128002622 rRNA interaction site [nucleotide binding]; other site 1147128002623 S8 interaction site; other site 1147128002624 putative laminin-1 binding site; other site 1147128002625 elongation factor Ts; Provisional; Region: tsf; PRK09377 1147128002626 UBA/TS-N domain; Region: UBA; pfam00627 1147128002627 Elongation factor TS; Region: EF_TS; pfam00889 1147128002628 Elongation factor TS; Region: EF_TS; pfam00889 1147128002629 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1147128002630 putative nucleotide binding site [chemical binding]; other site 1147128002631 uridine monophosphate binding site [chemical binding]; other site 1147128002632 homohexameric interface [polypeptide binding]; other site 1147128002633 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1147128002634 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1147128002635 hinge region; other site 1147128002636 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1147128002637 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1147128002638 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 1147128002639 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1147128002640 FeS/SAM binding site; other site 1147128002641 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1147128002642 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1147128002643 substrate binding site [chemical binding]; other site 1147128002644 glutamase interaction surface [polypeptide binding]; other site 1147128002645 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1147128002646 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 1147128002647 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1147128002648 active site 1147128002649 ribulose/triose binding site [chemical binding]; other site 1147128002650 phosphate binding site [ion binding]; other site 1147128002651 substrate (anthranilate) binding pocket [chemical binding]; other site 1147128002652 product (indole) binding pocket [chemical binding]; other site 1147128002653 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1147128002654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128002655 catalytic residue [active] 1147128002656 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1147128002657 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1147128002658 substrate binding site [chemical binding]; other site 1147128002659 active site 1147128002660 catalytic residues [active] 1147128002661 heterodimer interface [polypeptide binding]; other site 1147128002662 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1147128002663 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1147128002664 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1147128002665 substrate binding site [chemical binding]; other site 1147128002666 hexamer interface [polypeptide binding]; other site 1147128002667 metal binding site [ion binding]; metal-binding site 1147128002668 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 1147128002669 homodimer interface [polypeptide binding]; other site 1147128002670 putative metal binding site [ion binding]; other site 1147128002671 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1147128002672 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1147128002673 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1147128002674 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1147128002675 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1147128002676 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 1147128002677 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 1147128002678 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1147128002679 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1147128002680 phosphopeptide binding site; other site 1147128002681 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1147128002682 DNA binding residues [nucleotide binding] 1147128002683 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 1147128002684 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1147128002685 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1147128002686 motif II; other site 1147128002687 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1147128002688 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1147128002689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128002690 ATP binding site [chemical binding]; other site 1147128002691 putative Mg++ binding site [ion binding]; other site 1147128002692 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1147128002693 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 1147128002694 Predicted transcriptional regulator [Transcription]; Region: COG2378 1147128002695 WYL domain; Region: WYL; pfam13280 1147128002696 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1147128002697 active site 1147128002698 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1147128002699 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1147128002700 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1147128002701 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128002702 AAA domain; Region: AAA_21; pfam13304 1147128002703 Walker A/P-loop; other site 1147128002704 ATP binding site [chemical binding]; other site 1147128002705 Q-loop/lid; other site 1147128002706 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128002707 Q-loop/lid; other site 1147128002708 ABC transporter signature motif; other site 1147128002709 Walker B; other site 1147128002710 D-loop; other site 1147128002711 H-loop/switch region; other site 1147128002712 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1147128002713 active site 1147128002714 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1147128002715 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1147128002716 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1147128002717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128002718 active site 1147128002719 phosphorylation site [posttranslational modification] 1147128002720 intermolecular recognition site; other site 1147128002721 dimerization interface [polypeptide binding]; other site 1147128002722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1147128002723 DNA binding residues [nucleotide binding] 1147128002724 dimerization interface [polypeptide binding]; other site 1147128002725 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1147128002726 Histidine kinase; Region: HisKA_3; pfam07730 1147128002727 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1147128002728 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1147128002729 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1147128002730 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128002731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128002732 Walker A/P-loop; other site 1147128002733 ATP binding site [chemical binding]; other site 1147128002734 Q-loop/lid; other site 1147128002735 ABC transporter signature motif; other site 1147128002736 Walker B; other site 1147128002737 D-loop; other site 1147128002738 H-loop/switch region; other site 1147128002739 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1147128002740 Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592 1147128002741 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1147128002742 DNA binding residues [nucleotide binding] 1147128002743 dimer interface [polypeptide binding]; other site 1147128002744 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1147128002745 Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681 1147128002746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1147128002747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128002748 active site 1147128002749 phosphorylation site [posttranslational modification] 1147128002750 intermolecular recognition site; other site 1147128002751 dimerization interface [polypeptide binding]; other site 1147128002752 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1147128002753 DNA binding residues [nucleotide binding] 1147128002754 dimerization interface [polypeptide binding]; other site 1147128002755 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1147128002756 Histidine kinase; Region: HisKA_3; pfam07730 1147128002757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128002758 ATP binding site [chemical binding]; other site 1147128002759 Mg2+ binding site [ion binding]; other site 1147128002760 G-X-G motif; other site 1147128002761 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128002762 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128002763 putative substrate translocation pore; other site 1147128002764 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1147128002765 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128002766 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1147128002767 Walker A/P-loop; other site 1147128002768 ATP binding site [chemical binding]; other site 1147128002769 Q-loop/lid; other site 1147128002770 ABC transporter signature motif; other site 1147128002771 Walker B; other site 1147128002772 D-loop; other site 1147128002773 H-loop/switch region; other site 1147128002774 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 1147128002775 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1147128002776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1147128002777 DNA binding residues [nucleotide binding] 1147128002778 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1147128002779 DinB superfamily; Region: DinB_2; pfam12867 1147128002780 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128002781 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128002782 Walker A/P-loop; other site 1147128002783 ATP binding site [chemical binding]; other site 1147128002784 Q-loop/lid; other site 1147128002785 ABC transporter signature motif; other site 1147128002786 Walker B; other site 1147128002787 D-loop; other site 1147128002788 H-loop/switch region; other site 1147128002789 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1147128002790 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1147128002791 catalytic Zn binding site [ion binding]; other site 1147128002792 NAD(P) binding site [chemical binding]; other site 1147128002793 structural Zn binding site [ion binding]; other site 1147128002794 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1147128002795 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1147128002796 minor groove reading motif; other site 1147128002797 helix-hairpin-helix signature motif; other site 1147128002798 substrate binding pocket [chemical binding]; other site 1147128002799 active site 1147128002800 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1147128002801 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1147128002802 motif II; other site 1147128002803 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1147128002804 putative DNA binding site [nucleotide binding]; other site 1147128002805 dimerization interface [polypeptide binding]; other site 1147128002806 putative Zn2+ binding site [ion binding]; other site 1147128002807 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1147128002808 SdpI/YhfL protein family; Region: SdpI; pfam13630 1147128002809 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1147128002810 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 1147128002811 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1147128002812 CMP-binding site; other site 1147128002813 The sites determining sugar specificity; other site 1147128002814 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1147128002815 G1 box; other site 1147128002816 GTP/Mg2+ binding site [chemical binding]; other site 1147128002817 Switch I region; other site 1147128002818 G2 box; other site 1147128002819 Switch II region; other site 1147128002820 G3 box; other site 1147128002821 G4 box; other site 1147128002822 G5 box; other site 1147128002823 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1147128002824 G1 box; other site 1147128002825 GTP/Mg2+ binding site [chemical binding]; other site 1147128002826 Switch I region; other site 1147128002827 G2 box; other site 1147128002828 G3 box; other site 1147128002829 Switch II region; other site 1147128002830 G4 box; other site 1147128002831 G5 box; other site 1147128002832 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1147128002833 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1147128002834 RNA binding surface [nucleotide binding]; other site 1147128002835 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1147128002836 active site 1147128002837 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1147128002838 amphipathic channel; other site 1147128002839 Asn-Pro-Ala signature motifs; other site 1147128002840 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 1147128002841 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1147128002842 NAD(P) binding site [chemical binding]; other site 1147128002843 catalytic residues [active] 1147128002844 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1147128002845 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1147128002846 purine monophosphate binding site [chemical binding]; other site 1147128002847 dimer interface [polypeptide binding]; other site 1147128002848 putative catalytic residues [active] 1147128002849 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1147128002850 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1147128002851 CoA binding domain; Region: CoA_binding; smart00881 1147128002852 CoA-ligase; Region: Ligase_CoA; pfam00549 1147128002853 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1147128002854 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1147128002855 CoA-ligase; Region: Ligase_CoA; pfam00549 1147128002856 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1147128002857 active site 1147128002858 Preprotein translocase subunit; Region: YajC; pfam02699 1147128002859 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1147128002860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128002861 Walker A motif; other site 1147128002862 ATP binding site [chemical binding]; other site 1147128002863 Walker B motif; other site 1147128002864 arginine finger; other site 1147128002865 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1147128002866 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1147128002867 RuvA N terminal domain; Region: RuvA_N; pfam01330 1147128002868 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1147128002869 active site 1147128002870 putative DNA-binding cleft [nucleotide binding]; other site 1147128002871 dimer interface [polypeptide binding]; other site 1147128002872 hypothetical protein; Validated; Region: PRK00110 1147128002873 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1147128002874 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1147128002875 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1147128002876 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1147128002877 putative acyl-acceptor binding pocket; other site 1147128002878 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1147128002879 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1147128002880 thiS-thiF/thiG interaction site; other site 1147128002881 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1147128002882 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1147128002883 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1147128002884 active site 1147128002885 dimer interface [polypeptide binding]; other site 1147128002886 motif 1; other site 1147128002887 motif 2; other site 1147128002888 motif 3; other site 1147128002889 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 1147128002890 anticodon binding site; other site 1147128002891 PAC2 family; Region: PAC2; pfam09754 1147128002892 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1147128002893 YheO-like PAS domain; Region: PAS_6; pfam08348 1147128002894 HTH domain; Region: HTH_22; pfam13309 1147128002895 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128002896 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128002897 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002898 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002899 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002900 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002901 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128002902 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128002903 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128002904 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128002905 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 1147128002906 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1147128002907 chaperone protein DnaJ; Provisional; Region: PRK14278 1147128002908 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1147128002909 HSP70 interaction site [polypeptide binding]; other site 1147128002910 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1147128002911 Zn binding sites [ion binding]; other site 1147128002912 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1147128002913 dimer interface [polypeptide binding]; other site 1147128002914 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1147128002915 Ribosomal protein S19e; Region: Ribosomal_S19e; cl00969 1147128002916 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1147128002917 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1147128002918 TPP-binding site [chemical binding]; other site 1147128002919 dimer interface [polypeptide binding]; other site 1147128002920 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1147128002921 PYR/PP interface [polypeptide binding]; other site 1147128002922 dimer interface [polypeptide binding]; other site 1147128002923 TPP binding site [chemical binding]; other site 1147128002924 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1147128002925 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 1147128002926 putative active site [active] 1147128002927 transaldolase; Provisional; Region: PRK03903 1147128002928 catalytic residue [active] 1147128002929 ferrochelatase; Provisional; Region: PRK12435 1147128002930 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1147128002931 C-terminal domain interface [polypeptide binding]; other site 1147128002932 active site 1147128002933 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1147128002934 active site 1147128002935 N-terminal domain interface [polypeptide binding]; other site 1147128002936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128002937 putative substrate translocation pore; other site 1147128002938 putative heme peroxidase; Provisional; Region: PRK12276 1147128002939 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1147128002940 triosephosphate isomerase; Provisional; Region: PRK14567 1147128002941 substrate binding site [chemical binding]; other site 1147128002942 dimer interface [polypeptide binding]; other site 1147128002943 catalytic triad [active] 1147128002944 Phosphoglycerate kinase; Region: PGK; pfam00162 1147128002945 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1147128002946 substrate binding site [chemical binding]; other site 1147128002947 hinge regions; other site 1147128002948 ADP binding site [chemical binding]; other site 1147128002949 catalytic site [active] 1147128002950 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1147128002951 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 1147128002952 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1147128002953 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1147128002954 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1147128002955 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1147128002956 shikimate binding site; other site 1147128002957 NAD(P) binding site [chemical binding]; other site 1147128002958 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 1147128002959 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1147128002960 GIY-YIG motif/motif A; other site 1147128002961 active site 1147128002962 catalytic site [active] 1147128002963 putative DNA binding site [nucleotide binding]; other site 1147128002964 metal binding site [ion binding]; metal-binding site 1147128002965 UvrB/uvrC motif; Region: UVR; pfam02151 1147128002966 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1147128002967 Helix-hairpin-helix motif; Region: HHH; pfam00633 1147128002968 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1147128002969 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1147128002970 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1147128002971 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1147128002972 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1147128002973 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1147128002974 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128002975 Walker A/P-loop; other site 1147128002976 ATP binding site [chemical binding]; other site 1147128002977 Q-loop/lid; other site 1147128002978 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1147128002979 ABC transporter signature motif; other site 1147128002980 Walker B; other site 1147128002981 D-loop; other site 1147128002982 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1147128002983 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 1147128002984 MgtC family; Region: MgtC; pfam02308 1147128002985 Uncharacterized conserved protein [Function unknown]; Region: COG0062 1147128002986 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1147128002987 putative substrate binding site [chemical binding]; other site 1147128002988 putative ATP binding site [chemical binding]; other site 1147128002989 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1147128002990 catalytic core [active] 1147128002991 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1147128002992 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1147128002993 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1147128002994 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1147128002995 dimerization interface [polypeptide binding]; other site 1147128002996 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1147128002997 catalytic residues [active] 1147128002998 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1147128002999 active site 1147128003000 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1147128003001 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1147128003002 heterodimer interface [polypeptide binding]; other site 1147128003003 active site 1147128003004 FMN binding site [chemical binding]; other site 1147128003005 homodimer interface [polypeptide binding]; other site 1147128003006 substrate binding site [chemical binding]; other site 1147128003007 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiB; COG0543 1147128003008 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1147128003009 FAD binding pocket [chemical binding]; other site 1147128003010 FAD binding motif [chemical binding]; other site 1147128003011 phosphate binding motif [ion binding]; other site 1147128003012 beta-alpha-beta structure motif; other site 1147128003013 NAD binding pocket [chemical binding]; other site 1147128003014 Iron coordination center [ion binding]; other site 1147128003015 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1147128003016 active site 1147128003017 dimer interface [polypeptide binding]; other site 1147128003018 dihydroorotase; Validated; Region: pyrC; PRK09357 1147128003019 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1147128003020 active site 1147128003021 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1147128003022 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1147128003023 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1147128003024 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1147128003025 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1147128003026 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1147128003027 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 1147128003028 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1147128003029 metal binding triad; other site 1147128003030 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1147128003031 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1147128003032 metal binding triad; other site 1147128003033 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1147128003034 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1147128003035 FAD binding site [chemical binding]; other site 1147128003036 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1147128003037 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1147128003038 THF binding site; other site 1147128003039 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1147128003040 substrate binding site [chemical binding]; other site 1147128003041 THF binding site; other site 1147128003042 zinc-binding site [ion binding]; other site 1147128003043 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1147128003044 catalytic core [active] 1147128003045 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 1147128003046 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1147128003047 S-adenosylmethionine binding site [chemical binding]; other site 1147128003048 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128003049 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1147128003050 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1147128003051 Walker A/P-loop; other site 1147128003052 ATP binding site [chemical binding]; other site 1147128003053 Q-loop/lid; other site 1147128003054 ABC transporter signature motif; other site 1147128003055 Walker B; other site 1147128003056 D-loop; other site 1147128003057 H-loop/switch region; other site 1147128003058 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1147128003059 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128003060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003061 Walker A/P-loop; other site 1147128003062 ATP binding site [chemical binding]; other site 1147128003063 Q-loop/lid; other site 1147128003064 ABC transporter signature motif; other site 1147128003065 Walker B; other site 1147128003066 D-loop; other site 1147128003067 H-loop/switch region; other site 1147128003068 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1147128003069 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003070 Walker A/P-loop; other site 1147128003071 ATP binding site [chemical binding]; other site 1147128003072 ABC transporter signature motif; other site 1147128003073 Walker B; other site 1147128003074 D-loop; other site 1147128003075 H-loop/switch region; other site 1147128003076 P5-type ATPase cation transporter; Region: P5-ATPase; pfam12409 1147128003077 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1147128003078 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1147128003079 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1147128003080 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1147128003081 active site 1147128003082 dimer interface [polypeptide binding]; other site 1147128003083 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1147128003084 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1147128003085 active site 1147128003086 FMN binding site [chemical binding]; other site 1147128003087 substrate binding site [chemical binding]; other site 1147128003088 3Fe-4S cluster binding site [ion binding]; other site 1147128003089 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1147128003090 domain interface; other site 1147128003091 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1147128003092 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1147128003093 FeS/SAM binding site; other site 1147128003094 HemN C-terminal domain; Region: HemN_C; pfam06969 1147128003095 GTP-binding protein LepA; Provisional; Region: PRK05433 1147128003096 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1147128003097 G1 box; other site 1147128003098 putative GEF interaction site [polypeptide binding]; other site 1147128003099 GTP/Mg2+ binding site [chemical binding]; other site 1147128003100 Switch I region; other site 1147128003101 G2 box; other site 1147128003102 G3 box; other site 1147128003103 Switch II region; other site 1147128003104 G4 box; other site 1147128003105 G5 box; other site 1147128003106 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1147128003107 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1147128003108 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1147128003109 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1147128003110 Predicted membrane protein [Function unknown]; Region: COG2860 1147128003111 UPF0126 domain; Region: UPF0126; pfam03458 1147128003112 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1147128003113 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1147128003114 homodimer interface [polypeptide binding]; other site 1147128003115 substrate-cofactor binding pocket; other site 1147128003116 catalytic residue [active] 1147128003117 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1147128003118 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1147128003119 5S rRNA interface [nucleotide binding]; other site 1147128003120 CTC domain interface [polypeptide binding]; other site 1147128003121 L16 interface [polypeptide binding]; other site 1147128003122 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 1147128003123 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 1147128003124 acyl-activating enzyme (AAE) consensus motif; other site 1147128003125 putative AMP binding site [chemical binding]; other site 1147128003126 putative active site [active] 1147128003127 putative CoA binding site [chemical binding]; other site 1147128003128 GTPase Era; Reviewed; Region: era; PRK00089 1147128003129 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1147128003130 G1 box; other site 1147128003131 GTP/Mg2+ binding site [chemical binding]; other site 1147128003132 Switch I region; other site 1147128003133 G2 box; other site 1147128003134 Switch II region; other site 1147128003135 G3 box; other site 1147128003136 G4 box; other site 1147128003137 G5 box; other site 1147128003138 KH domain; Region: KH_2; pfam07650 1147128003139 FOG: CBS domain [General function prediction only]; Region: COG0517 1147128003140 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1147128003141 Transporter associated domain; Region: CorC_HlyC; smart01091 1147128003142 metal-binding heat shock protein; Provisional; Region: PRK00016 1147128003143 PhoH-like protein; Region: PhoH; pfam02562 1147128003144 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1147128003145 nucleotide binding site/active site [active] 1147128003146 HIT family signature motif; other site 1147128003147 catalytic residue [active] 1147128003148 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1147128003149 Helix-turn-helix domain; Region: HTH_36; pfam13730 1147128003150 Transcription factor WhiB; Region: Whib; pfam02467 1147128003151 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1147128003152 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1147128003153 P-loop; other site 1147128003154 Magnesium ion binding site [ion binding]; other site 1147128003155 Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710 1147128003156 Predicted deacylase [General function prediction only]; Region: COG3608 1147128003157 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1147128003158 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128003159 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128003160 Walker A/P-loop; other site 1147128003161 ATP binding site [chemical binding]; other site 1147128003162 Q-loop/lid; other site 1147128003163 ABC transporter signature motif; other site 1147128003164 Walker B; other site 1147128003165 D-loop; other site 1147128003166 H-loop/switch region; other site 1147128003167 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1147128003168 FtsX-like permease family; Region: FtsX; pfam02687 1147128003169 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 1147128003170 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1147128003171 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1147128003172 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1147128003173 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1147128003174 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1147128003175 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1147128003176 trimerization site [polypeptide binding]; other site 1147128003177 active site 1147128003178 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1147128003179 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1147128003180 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1147128003181 catalytic residue [active] 1147128003182 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1147128003183 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1147128003184 Walker A/P-loop; other site 1147128003185 ATP binding site [chemical binding]; other site 1147128003186 Q-loop/lid; other site 1147128003187 ABC transporter signature motif; other site 1147128003188 Walker B; other site 1147128003189 D-loop; other site 1147128003190 H-loop/switch region; other site 1147128003191 FeS assembly protein SufD; Region: sufD; TIGR01981 1147128003192 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1147128003193 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1147128003194 FeS assembly protein SufB; Region: sufB; TIGR01980 1147128003195 CTP synthetase; Validated; Region: pyrG; PRK05380 1147128003196 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1147128003197 Catalytic site [active] 1147128003198 active site 1147128003199 UTP binding site [chemical binding]; other site 1147128003200 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1147128003201 active site 1147128003202 putative oxyanion hole; other site 1147128003203 catalytic triad [active] 1147128003204 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003205 Walker A/P-loop; other site 1147128003206 ATP binding site [chemical binding]; other site 1147128003207 Q-loop/lid; other site 1147128003208 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 1147128003209 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003210 ABC transporter signature motif; other site 1147128003211 Walker B; other site 1147128003212 D-loop; other site 1147128003213 H-loop/switch region; other site 1147128003214 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003215 AAA domain; Region: AAA_21; pfam13304 1147128003216 Walker A/P-loop; other site 1147128003217 ATP binding site [chemical binding]; other site 1147128003218 Q-loop/lid; other site 1147128003219 ABC transporter signature motif; other site 1147128003220 Walker B; other site 1147128003221 D-loop; other site 1147128003222 H-loop/switch region; other site 1147128003223 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 1147128003224 Dehydroquinase class II; Region: DHquinase_II; pfam01220 1147128003225 trimer interface [polypeptide binding]; other site 1147128003226 active site 1147128003227 dimer interface [polypeptide binding]; other site 1147128003228 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 1147128003229 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1147128003230 ADP binding site [chemical binding]; other site 1147128003231 magnesium binding site [ion binding]; other site 1147128003232 putative shikimate binding site; other site 1147128003233 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1147128003234 active site 1147128003235 dimer interface [polypeptide binding]; other site 1147128003236 metal binding site [ion binding]; metal-binding site 1147128003237 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1147128003238 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1147128003239 Tetramer interface [polypeptide binding]; other site 1147128003240 active site 1147128003241 FMN-binding site [chemical binding]; other site 1147128003242 YceG-like family; Region: YceG; pfam02618 1147128003243 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 1147128003244 dimerization interface [polypeptide binding]; other site 1147128003245 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1147128003246 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1147128003247 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1147128003248 motif 1; other site 1147128003249 active site 1147128003250 motif 2; other site 1147128003251 motif 3; other site 1147128003252 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1147128003253 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 1147128003254 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1147128003255 catalytic core [active] 1147128003256 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1147128003257 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1147128003258 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1147128003259 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1147128003260 RNA binding surface [nucleotide binding]; other site 1147128003261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1147128003262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1147128003263 H+ Antiporter protein; Region: 2A0121; TIGR00900 1147128003264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128003265 putative substrate translocation pore; other site 1147128003266 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1147128003267 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1147128003268 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1147128003269 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1147128003270 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1147128003271 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128003272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003273 Walker A/P-loop; other site 1147128003274 ATP binding site [chemical binding]; other site 1147128003275 Q-loop/lid; other site 1147128003276 ABC transporter signature motif; other site 1147128003277 Walker B; other site 1147128003278 D-loop; other site 1147128003279 H-loop/switch region; other site 1147128003280 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1147128003281 Histidine kinase; Region: HisKA_3; pfam07730 1147128003282 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128003283 ATP binding site [chemical binding]; other site 1147128003284 Mg2+ binding site [ion binding]; other site 1147128003285 G-X-G motif; other site 1147128003286 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1147128003287 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128003288 active site 1147128003289 phosphorylation site [posttranslational modification] 1147128003290 intermolecular recognition site; other site 1147128003291 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1147128003292 DNA binding residues [nucleotide binding] 1147128003293 dimerization interface [polypeptide binding]; other site 1147128003294 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1147128003295 Part of AAA domain; Region: AAA_19; pfam13245 1147128003296 Family description; Region: UvrD_C_2; pfam13538 1147128003297 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1147128003298 active site 1147128003299 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 1147128003300 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1147128003301 homodimer interface [polypeptide binding]; other site 1147128003302 ligand binding site [chemical binding]; other site 1147128003303 NAD binding site [chemical binding]; other site 1147128003304 catalytic site [active] 1147128003305 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1147128003306 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1147128003307 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128003308 homodimer interface [polypeptide binding]; other site 1147128003309 catalytic residue [active] 1147128003310 short chain dehydrogenase; Validated; Region: PRK06182 1147128003311 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1147128003312 NADP binding site [chemical binding]; other site 1147128003313 active site 1147128003314 steroid binding site; other site 1147128003315 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1147128003316 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1147128003317 GMP synthase; Reviewed; Region: guaA; PRK00074 1147128003318 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1147128003319 AMP/PPi binding site [chemical binding]; other site 1147128003320 candidate oxyanion hole; other site 1147128003321 catalytic triad [active] 1147128003322 potential glutamine specificity residues [chemical binding]; other site 1147128003323 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1147128003324 ATP Binding subdomain [chemical binding]; other site 1147128003325 Ligand Binding sites [chemical binding]; other site 1147128003326 Dimerization subdomain; other site 1147128003327 putative phosphoketolase; Provisional; Region: PRK05261 1147128003328 XFP N-terminal domain; Region: XFP_N; pfam09364 1147128003329 XFP C-terminal domain; Region: XFP_C; pfam09363 1147128003330 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 1147128003331 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1147128003332 Glycosyl hydrolase family 31 (GH31) domain of a bacterial protein family represented by Escherichia coli protein Aec37. The gene encoding Aec37 (aec-37) is located within a genomic island (AGI-3) isolated from the extraintestinal avian pathogenic...; Region: GH31_glycosidase_Aec37; cd06599 1147128003333 putative active site [active] 1147128003334 putative catalytic site [active] 1147128003335 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128003336 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128003337 putative substrate translocation pore; other site 1147128003338 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128003339 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128003340 DNA binding site [nucleotide binding] 1147128003341 domain linker motif; other site 1147128003342 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128003343 ligand binding site [chemical binding]; other site 1147128003344 dimerization interface [polypeptide binding]; other site 1147128003345 AAA domain; Region: AAA_26; pfam13500 1147128003346 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 1147128003347 metal binding site [ion binding]; metal-binding site 1147128003348 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1147128003349 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1147128003350 propionate/acetate kinase; Provisional; Region: PRK12379 1147128003351 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1147128003352 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 1147128003353 active site 1147128003354 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1147128003355 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1147128003356 hinge; other site 1147128003357 active site 1147128003358 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1147128003359 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003360 Walker A/P-loop; other site 1147128003361 ATP binding site [chemical binding]; other site 1147128003362 Q-loop/lid; other site 1147128003363 ABC transporter signature motif; other site 1147128003364 Walker B; other site 1147128003365 D-loop; other site 1147128003366 H-loop/switch region; other site 1147128003367 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1147128003368 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1147128003369 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1147128003370 dimer interface [polypeptide binding]; other site 1147128003371 ADP-ribose binding site [chemical binding]; other site 1147128003372 active site 1147128003373 nudix motif; other site 1147128003374 metal binding site [ion binding]; metal-binding site 1147128003375 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1147128003376 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1147128003377 DNA polymerase I; Provisional; Region: PRK05755 1147128003378 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1147128003379 active site 1147128003380 metal binding site 1 [ion binding]; metal-binding site 1147128003381 putative 5' ssDNA interaction site; other site 1147128003382 metal binding site 3; metal-binding site 1147128003383 metal binding site 2 [ion binding]; metal-binding site 1147128003384 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1147128003385 putative DNA binding site [nucleotide binding]; other site 1147128003386 putative metal binding site [ion binding]; other site 1147128003387 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1147128003388 active site 1147128003389 substrate binding site [chemical binding]; other site 1147128003390 catalytic site [active] 1147128003391 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1147128003392 active site 1147128003393 DNA binding site [nucleotide binding] 1147128003394 catalytic site [active] 1147128003395 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1147128003396 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128003397 active site 1147128003398 phosphorylation site [posttranslational modification] 1147128003399 intermolecular recognition site; other site 1147128003400 dimerization interface [polypeptide binding]; other site 1147128003401 ANTAR domain; Region: ANTAR; pfam03861 1147128003402 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1147128003403 dimer interface [polypeptide binding]; other site 1147128003404 ADP-ribose binding site [chemical binding]; other site 1147128003405 active site 1147128003406 nudix motif; other site 1147128003407 metal binding site [ion binding]; metal-binding site 1147128003408 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1147128003409 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1147128003410 domain interfaces; other site 1147128003411 active site 1147128003412 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1147128003413 excinuclease ABC subunit B; Provisional; Region: PRK05298 1147128003414 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128003415 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128003416 nucleotide binding region [chemical binding]; other site 1147128003417 ATP-binding site [chemical binding]; other site 1147128003418 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1147128003419 UvrB/uvrC motif; Region: UVR; pfam02151 1147128003420 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1147128003421 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1147128003422 CoA-binding site [chemical binding]; other site 1147128003423 ATP-binding [chemical binding]; other site 1147128003424 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 1147128003425 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1147128003426 RNA binding site [nucleotide binding]; other site 1147128003427 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1147128003428 RNA binding site [nucleotide binding]; other site 1147128003429 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1147128003430 RNA binding site [nucleotide binding]; other site 1147128003431 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1147128003432 RNA binding site [nucleotide binding]; other site 1147128003433 domain interface; other site 1147128003434 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 1147128003435 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1147128003436 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1147128003437 homodimer interface [polypeptide binding]; other site 1147128003438 NADP binding site [chemical binding]; other site 1147128003439 substrate binding site [chemical binding]; other site 1147128003440 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1147128003441 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1147128003442 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1147128003443 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1147128003444 ABC-ATPase subunit interface; other site 1147128003445 dimer interface [polypeptide binding]; other site 1147128003446 putative PBP binding regions; other site 1147128003447 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 1147128003448 homotrimer interaction site [polypeptide binding]; other site 1147128003449 zinc binding site [ion binding]; other site 1147128003450 CDP-binding sites; other site 1147128003451 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 1147128003452 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1147128003453 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128003454 active site 1147128003455 phosphorylation site [posttranslational modification] 1147128003456 intermolecular recognition site; other site 1147128003457 dimerization interface [polypeptide binding]; other site 1147128003458 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1147128003459 DNA binding site [nucleotide binding] 1147128003460 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1147128003461 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1147128003462 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1147128003463 dimerization interface [polypeptide binding]; other site 1147128003464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1147128003465 dimer interface [polypeptide binding]; other site 1147128003466 phosphorylation site [posttranslational modification] 1147128003467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128003468 ATP binding site [chemical binding]; other site 1147128003469 Mg2+ binding site [ion binding]; other site 1147128003470 G-X-G motif; other site 1147128003471 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1147128003472 Catalytic site [active] 1147128003473 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1147128003474 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1147128003475 active site 1147128003476 DNA binding site [nucleotide binding] 1147128003477 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1147128003478 comF family protein; Region: comF; TIGR00201 1147128003479 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1147128003480 active site 1147128003481 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1147128003482 Eukaryotic phosphomannomutase; Region: PMM; cl17107 1147128003483 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 1147128003484 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1147128003485 Transcription factor WhiB; Region: Whib; pfam02467 1147128003486 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 1147128003487 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1147128003488 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1147128003489 Transcription factor WhiB; Region: Whib; pfam02467 1147128003490 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 1147128003491 PAS fold; Region: PAS_4; pfam08448 1147128003492 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 1147128003493 Histidine kinase; Region: HisKA_2; pfam07568 1147128003494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128003495 ATP binding site [chemical binding]; other site 1147128003496 Mg2+ binding site [ion binding]; other site 1147128003497 G-X-G motif; other site 1147128003498 Haemolysin-III related; Region: HlyIII; pfam03006 1147128003499 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1147128003500 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1147128003501 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1147128003502 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1147128003503 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1147128003504 exopolyphosphatase; Region: exo_poly_only; TIGR03706 1147128003505 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1147128003506 Protein of unknown function (DUF501); Region: DUF501; pfam04417 1147128003507 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1147128003508 Septum formation initiator; Region: DivIC; pfam04977 1147128003509 enolase; Provisional; Region: eno; PRK00077 1147128003510 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1147128003511 dimer interface [polypeptide binding]; other site 1147128003512 metal binding site [ion binding]; metal-binding site 1147128003513 substrate binding pocket [chemical binding]; other site 1147128003514 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1147128003515 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1147128003516 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128003517 ATP binding site [chemical binding]; other site 1147128003518 putative Mg++ binding site [ion binding]; other site 1147128003519 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128003520 nucleotide binding region [chemical binding]; other site 1147128003521 ATP-binding site [chemical binding]; other site 1147128003522 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1147128003523 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1147128003524 putative active site [active] 1147128003525 catalytic residue [active] 1147128003526 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1147128003527 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1147128003528 Coenzyme A binding pocket [chemical binding]; other site 1147128003529 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 1147128003530 Uncharacterized conserved protein [Function unknown]; Region: COG1615 1147128003531 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1147128003532 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1147128003533 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 1147128003534 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1147128003535 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 1147128003536 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128003537 dimer interface [polypeptide binding]; other site 1147128003538 conserved gate region; other site 1147128003539 putative PBP binding loops; other site 1147128003540 ABC-ATPase subunit interface; other site 1147128003541 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128003542 dimer interface [polypeptide binding]; other site 1147128003543 conserved gate region; other site 1147128003544 putative PBP binding loops; other site 1147128003545 ABC-ATPase subunit interface; other site 1147128003546 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1147128003547 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1147128003548 Walker A/P-loop; other site 1147128003549 ATP binding site [chemical binding]; other site 1147128003550 Q-loop/lid; other site 1147128003551 ABC transporter signature motif; other site 1147128003552 Walker B; other site 1147128003553 D-loop; other site 1147128003554 H-loop/switch region; other site 1147128003555 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 1147128003556 CrcB-like protein; Region: CRCB; pfam02537 1147128003557 CrcB-like protein; Region: CRCB; cl09114 1147128003558 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1147128003559 Sodium Bile acid symporter family; Region: SBF; pfam01758 1147128003560 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 1147128003561 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1147128003562 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1147128003563 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1147128003564 GTP-binding protein YchF; Reviewed; Region: PRK09601 1147128003565 YchF GTPase; Region: YchF; cd01900 1147128003566 G1 box; other site 1147128003567 GTP/Mg2+ binding site [chemical binding]; other site 1147128003568 Switch I region; other site 1147128003569 G2 box; other site 1147128003570 Switch II region; other site 1147128003571 G3 box; other site 1147128003572 G4 box; other site 1147128003573 G5 box; other site 1147128003574 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1147128003575 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1147128003576 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1147128003577 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1147128003578 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128003579 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128003580 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003581 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003582 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003583 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003584 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003585 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003586 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003587 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003588 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003589 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128003590 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1147128003591 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128003592 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003593 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003594 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003595 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003596 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003597 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003598 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003599 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003600 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003601 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128003602 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128003603 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003604 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003605 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003606 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003607 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003608 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003609 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003610 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003611 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003612 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003613 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128003614 Alpha-tubulin suppressor and related RCC1 domain-containing proteins [Cell division and chromosome partitioning / Cytoskeleton]; Region: ATS1; COG5184 1147128003615 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128003616 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003617 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003618 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003619 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003620 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003621 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003622 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128003623 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128003624 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128003625 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128003626 DNA binding site [nucleotide binding] 1147128003627 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1147128003628 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1147128003629 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1147128003630 substrate binding site [chemical binding]; other site 1147128003631 dimer interface [polypeptide binding]; other site 1147128003632 ATP binding site [chemical binding]; other site 1147128003633 Histidine kinase; Region: HisKA_3; pfam07730 1147128003634 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1147128003635 ATP binding site [chemical binding]; other site 1147128003636 Mg2+ binding site [ion binding]; other site 1147128003637 G-X-G motif; other site 1147128003638 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1147128003639 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128003640 active site 1147128003641 phosphorylation site [posttranslational modification] 1147128003642 intermolecular recognition site; other site 1147128003643 dimerization interface [polypeptide binding]; other site 1147128003644 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1147128003645 DNA binding residues [nucleotide binding] 1147128003646 dimerization interface [polypeptide binding]; other site 1147128003647 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1147128003648 FtsX-like permease family; Region: FtsX; pfam02687 1147128003649 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1147128003650 FtsX-like permease family; Region: FtsX; pfam02687 1147128003651 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128003652 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128003653 Walker A/P-loop; other site 1147128003654 ATP binding site [chemical binding]; other site 1147128003655 Q-loop/lid; other site 1147128003656 ABC transporter signature motif; other site 1147128003657 Walker B; other site 1147128003658 D-loop; other site 1147128003659 H-loop/switch region; other site 1147128003660 FtsX-like permease family; Region: FtsX; pfam02687 1147128003661 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1147128003662 FtsX-like permease family; Region: FtsX; pfam02687 1147128003663 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128003664 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128003665 Walker A/P-loop; other site 1147128003666 ATP binding site [chemical binding]; other site 1147128003667 Q-loop/lid; other site 1147128003668 ABC transporter signature motif; other site 1147128003669 Walker B; other site 1147128003670 D-loop; other site 1147128003671 H-loop/switch region; other site 1147128003672 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1147128003673 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1147128003674 homodimer interface [polypeptide binding]; other site 1147128003675 substrate-cofactor binding pocket; other site 1147128003676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128003677 catalytic residue [active] 1147128003678 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1147128003679 dimer interface [polypeptide binding]; other site 1147128003680 pyridoxal binding site [chemical binding]; other site 1147128003681 ATP binding site [chemical binding]; other site 1147128003682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1147128003683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1147128003684 hypothetical protein; Reviewed; Region: PRK12497 1147128003685 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1147128003686 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1147128003687 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 1147128003688 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1147128003689 DNA protecting protein DprA; Region: dprA; TIGR00732 1147128003690 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1147128003691 succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812 1147128003692 L-aspartate oxidase; Provisional; Region: PRK06175 1147128003693 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1147128003694 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1147128003695 catalytic loop [active] 1147128003696 iron binding site [ion binding]; other site 1147128003697 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1147128003698 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1147128003699 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1147128003700 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1147128003701 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1147128003702 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1147128003703 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 1147128003704 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128003705 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003706 Walker A/P-loop; other site 1147128003707 ATP binding site [chemical binding]; other site 1147128003708 Q-loop/lid; other site 1147128003709 ABC transporter signature motif; other site 1147128003710 Walker B; other site 1147128003711 D-loop; other site 1147128003712 H-loop/switch region; other site 1147128003713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1147128003714 MULE transposase domain; Region: MULE; pfam10551 1147128003715 ParB-like nuclease domain; Region: ParBc; pfam02195 1147128003716 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1147128003717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1147128003718 MULE transposase domain; Region: MULE; pfam10551 1147128003719 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 1147128003720 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128003721 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003722 Walker A/P-loop; other site 1147128003723 ATP binding site [chemical binding]; other site 1147128003724 Q-loop/lid; other site 1147128003725 ABC transporter signature motif; other site 1147128003726 Walker B; other site 1147128003727 D-loop; other site 1147128003728 H-loop/switch region; other site 1147128003729 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1147128003730 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128003731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128003732 Walker A/P-loop; other site 1147128003733 ATP binding site [chemical binding]; other site 1147128003734 Q-loop/lid; other site 1147128003735 ABC transporter signature motif; other site 1147128003736 Walker B; other site 1147128003737 D-loop; other site 1147128003738 H-loop/switch region; other site 1147128003739 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1147128003740 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 1147128003741 catalytic tetrad [active] 1147128003742 H+ Antiporter protein; Region: 2A0121; TIGR00900 1147128003743 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128003744 putative substrate translocation pore; other site 1147128003745 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128003746 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1147128003747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1147128003748 non-specific DNA binding site [nucleotide binding]; other site 1147128003749 salt bridge; other site 1147128003750 sequence-specific DNA binding site [nucleotide binding]; other site 1147128003751 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1147128003752 active site 1147128003753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128003754 putative substrate translocation pore; other site 1147128003755 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128003756 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128003757 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128003758 DNA binding site [nucleotide binding] 1147128003759 domain linker motif; other site 1147128003760 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128003761 dimerization interface [polypeptide binding]; other site 1147128003762 ligand binding site [chemical binding]; other site 1147128003763 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1147128003764 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1147128003765 RNA binding surface [nucleotide binding]; other site 1147128003766 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1147128003767 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 1147128003768 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1147128003769 active site 1147128003770 motif I; other site 1147128003771 motif II; other site 1147128003772 PIN domain; Region: PIN; pfam01850 1147128003773 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 1147128003774 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1147128003775 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1147128003776 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1147128003777 active site 1147128003778 HIGH motif; other site 1147128003779 dimer interface [polypeptide binding]; other site 1147128003780 KMSKS motif; other site 1147128003781 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1147128003782 RNA binding surface [nucleotide binding]; other site 1147128003783 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 1147128003784 active site 1147128003785 catalytic triad [active] 1147128003786 oxyanion hole [active] 1147128003787 argininosuccinate lyase; Provisional; Region: PRK00855 1147128003788 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1147128003789 active sites [active] 1147128003790 tetramer interface [polypeptide binding]; other site 1147128003791 argininosuccinate synthase; Provisional; Region: PRK13820 1147128003792 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1147128003793 ANP binding site [chemical binding]; other site 1147128003794 Substrate Binding Site II [chemical binding]; other site 1147128003795 Substrate Binding Site I [chemical binding]; other site 1147128003796 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1147128003797 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1147128003798 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1147128003799 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1147128003800 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1147128003801 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 1147128003802 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1147128003803 inhibitor-cofactor binding pocket; inhibition site 1147128003804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128003805 catalytic residue [active] 1147128003806 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1147128003807 feedback inhibition sensing region; other site 1147128003808 homohexameric interface [polypeptide binding]; other site 1147128003809 nucleotide binding site [chemical binding]; other site 1147128003810 N-acetyl-L-glutamate binding site [chemical binding]; other site 1147128003811 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1147128003812 heterotetramer interface [polypeptide binding]; other site 1147128003813 active site pocket [active] 1147128003814 cleavage site 1147128003815 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1147128003816 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1147128003817 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139 1147128003818 conserved cys residue [active] 1147128003819 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 1147128003820 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1147128003821 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1147128003822 putative tRNA-binding site [nucleotide binding]; other site 1147128003823 B3/4 domain; Region: B3_4; pfam03483 1147128003824 tRNA synthetase B5 domain; Region: B5; smart00874 1147128003825 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1147128003826 dimer interface [polypeptide binding]; other site 1147128003827 motif 1; other site 1147128003828 motif 3; other site 1147128003829 motif 2; other site 1147128003830 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1147128003831 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1147128003832 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1147128003833 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1147128003834 dimer interface [polypeptide binding]; other site 1147128003835 motif 1; other site 1147128003836 active site 1147128003837 motif 2; other site 1147128003838 motif 3; other site 1147128003839 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1147128003840 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1147128003841 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1147128003842 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1147128003843 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1147128003844 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1147128003845 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1147128003846 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1147128003847 Walker A/P-loop; other site 1147128003848 ATP binding site [chemical binding]; other site 1147128003849 Q-loop/lid; other site 1147128003850 ABC transporter signature motif; other site 1147128003851 Walker B; other site 1147128003852 D-loop; other site 1147128003853 H-loop/switch region; other site 1147128003854 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1147128003855 Walker A/P-loop; other site 1147128003856 ATP binding site [chemical binding]; other site 1147128003857 Q-loop/lid; other site 1147128003858 ABC transporter signature motif; other site 1147128003859 Walker B; other site 1147128003860 D-loop; other site 1147128003861 H-loop/switch region; other site 1147128003862 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1147128003863 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 1147128003864 hypothetical protein; Provisional; Region: PRK07907 1147128003865 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 1147128003866 active site 1147128003867 metal binding site [ion binding]; metal-binding site 1147128003868 dimer interface [polypeptide binding]; other site 1147128003869 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 1147128003870 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1147128003871 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1147128003872 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1147128003873 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1147128003874 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 1147128003875 glutamine synthetase, type I; Region: GlnA; TIGR00653 1147128003876 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1147128003877 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1147128003878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128003879 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128003880 Domain of unknown function DUF59; Region: DUF59; cl00941 1147128003881 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1147128003882 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1147128003883 Walker A motif; other site 1147128003884 Ligase N family; Region: LIGANc; smart00532 1147128003885 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1147128003886 nucleotide binding pocket [chemical binding]; other site 1147128003887 K-X-D-G motif; other site 1147128003888 catalytic site [active] 1147128003889 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1147128003890 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1147128003891 Helix-hairpin-helix motif; Region: HHH; pfam00633 1147128003892 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1147128003893 Dimer interface [polypeptide binding]; other site 1147128003894 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1147128003895 binding surface 1147128003896 TPR motif; other site 1147128003897 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1147128003898 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1147128003899 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 1147128003900 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1147128003901 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128003902 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128003903 putative substrate translocation pore; other site 1147128003904 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1147128003905 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1147128003906 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128003907 homodimer interface [polypeptide binding]; other site 1147128003908 catalytic residue [active] 1147128003909 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1147128003910 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1147128003911 nucleotide binding site [chemical binding]; other site 1147128003912 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 1147128003913 FMN binding site [chemical binding]; other site 1147128003914 dimer interface [polypeptide binding]; other site 1147128003915 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1147128003916 catalytic core [active] 1147128003917 FtsX-like permease family; Region: FtsX; pfam02687 1147128003918 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1147128003919 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128003920 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128003921 Walker A/P-loop; other site 1147128003922 ATP binding site [chemical binding]; other site 1147128003923 Q-loop/lid; other site 1147128003924 ABC transporter signature motif; other site 1147128003925 Walker B; other site 1147128003926 D-loop; other site 1147128003927 H-loop/switch region; other site 1147128003928 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128003929 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1147128003930 Walker A/P-loop; other site 1147128003931 ATP binding site [chemical binding]; other site 1147128003932 Q-loop/lid; other site 1147128003933 ABC transporter signature motif; other site 1147128003934 Walker B; other site 1147128003935 D-loop; other site 1147128003936 H-loop/switch region; other site 1147128003937 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1147128003938 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1147128003939 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 1147128003940 DNA binding residues [nucleotide binding] 1147128003941 Predicted membrane protein [Function unknown]; Region: COG3601 1147128003942 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1147128003943 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1147128003944 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1147128003945 Walker A/P-loop; other site 1147128003946 ATP binding site [chemical binding]; other site 1147128003947 Q-loop/lid; other site 1147128003948 ABC transporter signature motif; other site 1147128003949 Walker B; other site 1147128003950 D-loop; other site 1147128003951 H-loop/switch region; other site 1147128003952 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1147128003953 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1147128003954 Walker A/P-loop; other site 1147128003955 ATP binding site [chemical binding]; other site 1147128003956 Q-loop/lid; other site 1147128003957 ABC transporter signature motif; other site 1147128003958 Walker B; other site 1147128003959 D-loop; other site 1147128003960 H-loop/switch region; other site 1147128003961 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1147128003962 Clp protease ATP binding subunit; Region: clpC; CHL00095 1147128003963 Clp amino terminal domain; Region: Clp_N; pfam02861 1147128003964 Clp amino terminal domain; Region: Clp_N; pfam02861 1147128003965 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128003966 Walker A motif; other site 1147128003967 ATP binding site [chemical binding]; other site 1147128003968 Walker B motif; other site 1147128003969 arginine finger; other site 1147128003970 UvrB/uvrC motif; Region: UVR; pfam02151 1147128003971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128003972 Walker A motif; other site 1147128003973 ATP binding site [chemical binding]; other site 1147128003974 Walker B motif; other site 1147128003975 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1147128003976 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 1147128003977 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1147128003978 DNA-binding site [nucleotide binding]; DNA binding site 1147128003979 RNA-binding motif; other site 1147128003980 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1147128003981 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1147128003982 dimerization interface [polypeptide binding]; other site 1147128003983 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1147128003984 dimer interface [polypeptide binding]; other site 1147128003985 phosphorylation site [posttranslational modification] 1147128003986 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128003987 ATP binding site [chemical binding]; other site 1147128003988 Mg2+ binding site [ion binding]; other site 1147128003989 G-X-G motif; other site 1147128003990 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1147128003991 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128003992 active site 1147128003993 phosphorylation site [posttranslational modification] 1147128003994 intermolecular recognition site; other site 1147128003995 dimerization interface [polypeptide binding]; other site 1147128003996 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1147128003997 DNA binding site [nucleotide binding] 1147128003998 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1147128003999 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1147128004000 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1147128004001 ring oligomerisation interface [polypeptide binding]; other site 1147128004002 ATP/Mg binding site [chemical binding]; other site 1147128004003 stacking interactions; other site 1147128004004 hinge regions; other site 1147128004005 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1147128004006 DNA-binding site [nucleotide binding]; DNA binding site 1147128004007 RNA-binding motif; other site 1147128004008 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1147128004009 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1147128004010 ligand binding site [chemical binding]; other site 1147128004011 active site 1147128004012 UGI interface [polypeptide binding]; other site 1147128004013 catalytic site [active] 1147128004014 MoxR-like ATPases [General function prediction only]; Region: COG0714 1147128004015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1147128004016 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1147128004017 Protein of unknown function DUF58; Region: DUF58; pfam01882 1147128004018 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1147128004019 metal ion-dependent adhesion site (MIDAS); other site 1147128004020 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1147128004021 metal ion-dependent adhesion site (MIDAS); other site 1147128004022 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1147128004023 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1147128004024 nucleophilic elbow; other site 1147128004025 catalytic triad; other site 1147128004026 adenylosuccinate lyase; Provisional; Region: PRK09285 1147128004027 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1147128004028 tetramer interface [polypeptide binding]; other site 1147128004029 active site 1147128004030 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1147128004031 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1147128004032 IHF dimer interface [polypeptide binding]; other site 1147128004033 IHF - DNA interface [nucleotide binding]; other site 1147128004034 Pup-ligase protein; Region: Pup_ligase; cl15463 1147128004035 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 1147128004036 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1147128004037 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1147128004038 active site 1147128004039 Pup-ligase protein; Region: Pup_ligase; pfam03136 1147128004040 proteasome ATPase; Region: pup_AAA; TIGR03689 1147128004041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128004042 Walker A motif; other site 1147128004043 ATP binding site [chemical binding]; other site 1147128004044 Walker B motif; other site 1147128004045 arginine finger; other site 1147128004046 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1147128004047 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1147128004048 putative active site [active] 1147128004049 substrate binding site [chemical binding]; other site 1147128004050 putative cosubstrate binding site; other site 1147128004051 catalytic site [active] 1147128004052 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1147128004053 substrate binding site [chemical binding]; other site 1147128004054 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1147128004055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1147128004056 motif II; other site 1147128004057 primosome assembly protein PriA; Provisional; Region: PRK14873 1147128004058 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1147128004059 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1147128004060 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1147128004061 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1147128004062 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1147128004063 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1147128004064 Guanylate kinase; Region: Guanylate_kin; pfam00625 1147128004065 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1147128004066 catalytic site [active] 1147128004067 G-X2-G-X-G-K; other site 1147128004068 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1147128004069 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1147128004070 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1147128004071 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1147128004072 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1147128004073 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1147128004074 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1147128004075 IMP binding site; other site 1147128004076 dimer interface [polypeptide binding]; other site 1147128004077 interdomain contacts; other site 1147128004078 partial ornithine binding site; other site 1147128004079 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1147128004080 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1147128004081 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1147128004082 catalytic site [active] 1147128004083 subunit interface [polypeptide binding]; other site 1147128004084 transcription antitermination factor NusB; Region: nusB; TIGR01951 1147128004085 putative RNA binding site [nucleotide binding]; other site 1147128004086 elongation factor P; Validated; Region: PRK00529 1147128004087 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1147128004088 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1147128004089 RNA binding site [nucleotide binding]; other site 1147128004090 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1147128004091 RNA binding site [nucleotide binding]; other site 1147128004092 elongation factor Tu; Reviewed; Region: PRK00049 1147128004093 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1147128004094 G1 box; other site 1147128004095 GEF interaction site [polypeptide binding]; other site 1147128004096 GTP/Mg2+ binding site [chemical binding]; other site 1147128004097 Switch I region; other site 1147128004098 G2 box; other site 1147128004099 G3 box; other site 1147128004100 Switch II region; other site 1147128004101 G4 box; other site 1147128004102 G5 box; other site 1147128004103 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1147128004104 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1147128004105 Antibiotic Binding Site [chemical binding]; other site 1147128004106 elongation factor G; Reviewed; Region: PRK00007 1147128004107 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1147128004108 G1 box; other site 1147128004109 putative GEF interaction site [polypeptide binding]; other site 1147128004110 GTP/Mg2+ binding site [chemical binding]; other site 1147128004111 Switch I region; other site 1147128004112 G2 box; other site 1147128004113 G3 box; other site 1147128004114 Switch II region; other site 1147128004115 G4 box; other site 1147128004116 G5 box; other site 1147128004117 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1147128004118 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1147128004119 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1147128004120 30S ribosomal protein S7; Validated; Region: PRK05302 1147128004121 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1147128004122 S17 interaction site [polypeptide binding]; other site 1147128004123 S8 interaction site; other site 1147128004124 16S rRNA interaction site [nucleotide binding]; other site 1147128004125 streptomycin interaction site [chemical binding]; other site 1147128004126 23S rRNA interaction site [nucleotide binding]; other site 1147128004127 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1147128004128 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1147128004129 YwiC-like protein; Region: YwiC; pfam14256 1147128004130 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 1147128004131 putative active site [active] 1147128004132 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 1147128004133 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1147128004134 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1147128004135 Family description; Region: ACT_7; pfam13840 1147128004136 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1147128004137 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1147128004138 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 1147128004139 ligand binding site [chemical binding]; other site 1147128004140 homodimer interface [polypeptide binding]; other site 1147128004141 NAD(P) binding site [chemical binding]; other site 1147128004142 trimer interface B [polypeptide binding]; other site 1147128004143 trimer interface A [polypeptide binding]; other site 1147128004144 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1147128004145 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 1147128004146 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1147128004147 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1147128004148 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1147128004149 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1147128004150 catalytic residue [active] 1147128004151 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1147128004152 D-arabinose dehydrogenase; Region: arabinose_DH_like; cd05284 1147128004153 NAD binding site [chemical binding]; other site 1147128004154 substrate binding site [chemical binding]; other site 1147128004155 catalytic Zn binding site [ion binding]; other site 1147128004156 structural Zn binding site [ion binding]; other site 1147128004157 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1147128004158 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1147128004159 dimer interface [polypeptide binding]; other site 1147128004160 phosphorylation site [posttranslational modification] 1147128004161 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128004162 ATP binding site [chemical binding]; other site 1147128004163 Mg2+ binding site [ion binding]; other site 1147128004164 G-X-G motif; other site 1147128004165 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1147128004166 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128004167 active site 1147128004168 phosphorylation site [posttranslational modification] 1147128004169 intermolecular recognition site; other site 1147128004170 dimerization interface [polypeptide binding]; other site 1147128004171 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1147128004172 DNA binding site [nucleotide binding] 1147128004173 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128004174 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128004175 Walker A/P-loop; other site 1147128004176 ATP binding site [chemical binding]; other site 1147128004177 Q-loop/lid; other site 1147128004178 ABC transporter signature motif; other site 1147128004179 Walker B; other site 1147128004180 D-loop; other site 1147128004181 H-loop/switch region; other site 1147128004182 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1147128004183 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1147128004184 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1147128004185 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1147128004186 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1147128004187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128004188 dimer interface [polypeptide binding]; other site 1147128004189 conserved gate region; other site 1147128004190 ABC-ATPase subunit interface; other site 1147128004191 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1147128004192 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1147128004193 Walker A/P-loop; other site 1147128004194 ATP binding site [chemical binding]; other site 1147128004195 Q-loop/lid; other site 1147128004196 ABC transporter signature motif; other site 1147128004197 Walker B; other site 1147128004198 D-loop; other site 1147128004199 H-loop/switch region; other site 1147128004200 NIL domain; Region: NIL; pfam09383 1147128004201 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1147128004202 ATP-grasp domain; Region: ATP-grasp; pfam02222 1147128004203 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1147128004204 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1147128004205 active site 1147128004206 ATP binding site [chemical binding]; other site 1147128004207 substrate binding site [chemical binding]; other site 1147128004208 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1147128004209 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1147128004210 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1147128004211 dimerization interface [polypeptide binding]; other site 1147128004212 ATP binding site [chemical binding]; other site 1147128004213 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1147128004214 dimerization interface [polypeptide binding]; other site 1147128004215 ATP binding site [chemical binding]; other site 1147128004216 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1147128004217 putative active site [active] 1147128004218 catalytic triad [active] 1147128004219 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1147128004220 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1147128004221 active site 1147128004222 tetramer interface [polypeptide binding]; other site 1147128004223 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1147128004224 active site 1147128004225 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1147128004226 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1147128004227 dimerization interface [polypeptide binding]; other site 1147128004228 putative ATP binding site [chemical binding]; other site 1147128004229 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1147128004230 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1147128004231 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1147128004232 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1147128004233 Sulfatase; Region: Sulfatase; pfam00884 1147128004234 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1147128004235 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1147128004236 intersubunit interface [polypeptide binding]; other site 1147128004237 Predicted esterase [General function prediction only]; Region: COG0627 1147128004238 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 1147128004239 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1147128004240 metal binding site 2 [ion binding]; metal-binding site 1147128004241 putative DNA binding helix; other site 1147128004242 metal binding site 1 [ion binding]; metal-binding site 1147128004243 dimer interface [polypeptide binding]; other site 1147128004244 structural Zn2+ binding site [ion binding]; other site 1147128004245 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1147128004246 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1147128004247 NAD binding site [chemical binding]; other site 1147128004248 ATP-grasp domain; Region: ATP-grasp; pfam02222 1147128004249 AIR carboxylase; Region: AIRC; pfam00731 1147128004250 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 1147128004251 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1147128004252 TPP-binding site; other site 1147128004253 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1147128004254 PYR/PP interface [polypeptide binding]; other site 1147128004255 dimer interface [polypeptide binding]; other site 1147128004256 TPP binding site [chemical binding]; other site 1147128004257 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1147128004258 dimer interface [polypeptide binding]; other site 1147128004259 ADP-ribose binding site [chemical binding]; other site 1147128004260 active site 1147128004261 nudix motif; other site 1147128004262 metal binding site [ion binding]; metal-binding site 1147128004263 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1147128004264 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128004265 Glycosyl hydrolases family 28; Region: Glyco_hydro_28; pfam00295 1147128004266 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1147128004267 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1147128004268 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1147128004269 NnrS protein; Region: NnrS; cl01258 1147128004270 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 1147128004271 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1147128004272 Ferredoxin [Energy production and conversion]; Region: COG1146 1147128004273 4Fe-4S binding domain; Region: Fer4; pfam00037 1147128004274 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1147128004275 active site 1147128004276 DNA binding site [nucleotide binding] 1147128004277 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1147128004278 transmembrane helices; other site 1147128004279 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1147128004280 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128004281 putative substrate translocation pore; other site 1147128004282 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1147128004283 active site 1147128004284 tetramer interface [polypeptide binding]; other site 1147128004285 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1147128004286 GIY-YIG motif/motif A; other site 1147128004287 active site 1147128004288 catalytic site [active] 1147128004289 metal binding site [ion binding]; metal-binding site 1147128004290 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 1147128004291 Uncharacterized conserved protein [Function unknown]; Region: COG3410 1147128004292 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 1147128004293 homodimer interface [polypeptide binding]; other site 1147128004294 chemical substrate binding site [chemical binding]; other site 1147128004295 oligomer interface [polypeptide binding]; other site 1147128004296 metal binding site [ion binding]; metal-binding site 1147128004297 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1147128004298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1147128004299 active site 1147128004300 motif I; other site 1147128004301 motif II; other site 1147128004302 DNA primase; Validated; Region: dnaG; PRK05667 1147128004303 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1147128004304 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1147128004305 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1147128004306 active site 1147128004307 metal binding site [ion binding]; metal-binding site 1147128004308 interdomain interaction site; other site 1147128004309 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1147128004310 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 1147128004311 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1147128004312 Zn2+ binding site [ion binding]; other site 1147128004313 Mg2+ binding site [ion binding]; other site 1147128004314 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1147128004315 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 1147128004316 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1147128004317 alanine racemase; Reviewed; Region: alr; PRK00053 1147128004318 active site 1147128004319 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1147128004320 dimer interface [polypeptide binding]; other site 1147128004321 substrate binding site [chemical binding]; other site 1147128004322 catalytic residues [active] 1147128004323 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1147128004324 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1147128004325 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 1147128004326 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128004327 ATP binding site [chemical binding]; other site 1147128004328 putative Mg++ binding site [ion binding]; other site 1147128004329 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1147128004330 nucleotide binding region [chemical binding]; other site 1147128004331 ATP-binding site [chemical binding]; other site 1147128004332 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1147128004333 HRDC domain; Region: HRDC; pfam00570 1147128004334 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128004335 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1147128004336 Walker A/P-loop; other site 1147128004337 ATP binding site [chemical binding]; other site 1147128004338 Q-loop/lid; other site 1147128004339 ABC transporter signature motif; other site 1147128004340 Walker B; other site 1147128004341 D-loop; other site 1147128004342 H-loop/switch region; other site 1147128004343 Predicted transcriptional regulators [Transcription]; Region: COG1725 1147128004344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1147128004345 DNA-binding site [nucleotide binding]; DNA binding site 1147128004346 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1147128004347 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1147128004348 Walker A/P-loop; other site 1147128004349 ATP binding site [chemical binding]; other site 1147128004350 Q-loop/lid; other site 1147128004351 ABC transporter signature motif; other site 1147128004352 Walker B; other site 1147128004353 D-loop; other site 1147128004354 H-loop/switch region; other site 1147128004355 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1147128004356 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1147128004357 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1147128004358 Walker A/P-loop; other site 1147128004359 ATP binding site [chemical binding]; other site 1147128004360 Q-loop/lid; other site 1147128004361 ABC transporter signature motif; other site 1147128004362 Walker B; other site 1147128004363 D-loop; other site 1147128004364 H-loop/switch region; other site 1147128004365 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1147128004366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128004367 dimer interface [polypeptide binding]; other site 1147128004368 conserved gate region; other site 1147128004369 putative PBP binding loops; other site 1147128004370 ABC-ATPase subunit interface; other site 1147128004371 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1147128004372 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128004373 dimer interface [polypeptide binding]; other site 1147128004374 conserved gate region; other site 1147128004375 putative PBP binding loops; other site 1147128004376 ABC-ATPase subunit interface; other site 1147128004377 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1147128004378 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 1147128004379 pantothenate kinase; Reviewed; Region: PRK13318 1147128004380 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1147128004381 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1147128004382 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1147128004383 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1147128004384 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1147128004385 active site 1147128004386 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1147128004387 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1147128004388 glutaminase active site [active] 1147128004389 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1147128004390 dimer interface [polypeptide binding]; other site 1147128004391 active site 1147128004392 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1147128004393 dimer interface [polypeptide binding]; other site 1147128004394 active site 1147128004395 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1147128004396 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1147128004397 Walker A/P-loop; other site 1147128004398 ATP binding site [chemical binding]; other site 1147128004399 Q-loop/lid; other site 1147128004400 ABC transporter signature motif; other site 1147128004401 Walker B; other site 1147128004402 D-loop; other site 1147128004403 H-loop/switch region; other site 1147128004404 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1147128004405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128004406 dimer interface [polypeptide binding]; other site 1147128004407 conserved gate region; other site 1147128004408 putative PBP binding loops; other site 1147128004409 ABC-ATPase subunit interface; other site 1147128004410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1147128004411 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1147128004412 substrate binding pocket [chemical binding]; other site 1147128004413 membrane-bound complex binding site; other site 1147128004414 hinge residues; other site 1147128004415 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1147128004416 SmpB-tmRNA interface; other site 1147128004417 CHAP domain; Region: CHAP; pfam05257 1147128004418 Surface antigen [General function prediction only]; Region: COG3942 1147128004419 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1147128004420 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1147128004421 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128004422 Walker A/P-loop; other site 1147128004423 ATP binding site [chemical binding]; other site 1147128004424 Q-loop/lid; other site 1147128004425 ABC transporter signature motif; other site 1147128004426 Walker B; other site 1147128004427 D-loop; other site 1147128004428 H-loop/switch region; other site 1147128004429 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1147128004430 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1147128004431 RF-1 domain; Region: RF-1; pfam00472 1147128004432 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 1147128004433 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 1147128004434 putative trimer interface [polypeptide binding]; other site 1147128004435 putative CoA binding site [chemical binding]; other site 1147128004436 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 1147128004437 Citrate synthase; Region: Citrate_synt; pfam00285 1147128004438 oxalacetate binding site [chemical binding]; other site 1147128004439 citrylCoA binding site [chemical binding]; other site 1147128004440 coenzyme A binding site [chemical binding]; other site 1147128004441 catalytic triad [active] 1147128004442 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1147128004443 active site 1147128004444 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1147128004445 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1147128004446 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1147128004447 active site 1147128004448 Zn binding site [ion binding]; other site 1147128004449 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1147128004450 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1147128004451 dimer interface [polypeptide binding]; other site 1147128004452 ssDNA binding site [nucleotide binding]; other site 1147128004453 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1147128004454 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1147128004455 active site 1147128004456 putative catalytic site [active] 1147128004457 DNA binding site [nucleotide binding] 1147128004458 putative phosphate binding site [ion binding]; other site 1147128004459 metal binding site A [ion binding]; metal-binding site 1147128004460 AP binding site [nucleotide binding]; other site 1147128004461 metal binding site B [ion binding]; metal-binding site 1147128004462 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1147128004463 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1147128004464 dimer interface [polypeptide binding]; other site 1147128004465 motif 1; other site 1147128004466 active site 1147128004467 motif 2; other site 1147128004468 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1147128004469 putative deacylase active site [active] 1147128004470 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1147128004471 active site 1147128004472 motif 3; other site 1147128004473 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1147128004474 anticodon binding site; other site 1147128004475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128004476 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128004477 Walker A/P-loop; other site 1147128004478 ATP binding site [chemical binding]; other site 1147128004479 Q-loop/lid; other site 1147128004480 ABC transporter signature motif; other site 1147128004481 Walker B; other site 1147128004482 D-loop; other site 1147128004483 H-loop/switch region; other site 1147128004484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1147128004485 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1147128004486 Coenzyme A binding pocket [chemical binding]; other site 1147128004487 AAA domain; Region: AAA_30; pfam13604 1147128004488 PIF1-like helicase; Region: PIF1; pfam05970 1147128004489 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1147128004490 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1147128004491 catalytic site [active] 1147128004492 putative active site [active] 1147128004493 putative substrate binding site [chemical binding]; other site 1147128004494 dimer interface [polypeptide binding]; other site 1147128004495 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1147128004496 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1147128004497 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1147128004498 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1147128004499 active site 1147128004500 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1147128004501 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1147128004502 Mg++ binding site [ion binding]; other site 1147128004503 putative catalytic motif [active] 1147128004504 substrate binding site [chemical binding]; other site 1147128004505 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1147128004506 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1147128004507 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1147128004508 S-adenosylmethionine binding site [chemical binding]; other site 1147128004509 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1147128004510 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1147128004511 RF-1 domain; Region: RF-1; pfam00472 1147128004512 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1147128004513 acetoin reductase; Validated; Region: PRK08643 1147128004514 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 1147128004515 NAD binding site [chemical binding]; other site 1147128004516 homotetramer interface [polypeptide binding]; other site 1147128004517 homodimer interface [polypeptide binding]; other site 1147128004518 active site 1147128004519 substrate binding site [chemical binding]; other site 1147128004520 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1147128004521 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1147128004522 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128004523 homodimer interface [polypeptide binding]; other site 1147128004524 catalytic residue [active] 1147128004525 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1147128004526 YheO-like PAS domain; Region: PAS_6; pfam08348 1147128004527 HTH domain; Region: HTH_22; pfam13309 1147128004528 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 1147128004529 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1147128004530 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 1147128004531 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1147128004532 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128004533 Walker A/P-loop; other site 1147128004534 ATP binding site [chemical binding]; other site 1147128004535 Q-loop/lid; other site 1147128004536 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1147128004537 ABC transporter; Region: ABC_tran_2; pfam12848 1147128004538 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1147128004539 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 1147128004540 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1147128004541 active site 1147128004542 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1147128004543 catalytic triad [active] 1147128004544 dimer interface [polypeptide binding]; other site 1147128004545 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 1147128004546 active site 1147128004547 Dihydroneopterin aldolase; Region: FolB; smart00905 1147128004548 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 1147128004549 FtsH Extracellular; Region: FtsH_ext; pfam06480 1147128004550 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1147128004551 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128004552 Walker A motif; other site 1147128004553 ATP binding site [chemical binding]; other site 1147128004554 Walker B motif; other site 1147128004555 arginine finger; other site 1147128004556 Peptidase family M41; Region: Peptidase_M41; pfam01434 1147128004557 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1147128004558 active site 1147128004559 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1147128004560 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1147128004561 Ligand Binding Site [chemical binding]; other site 1147128004562 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1147128004563 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1147128004564 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1147128004565 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1147128004566 Walker A/P-loop; other site 1147128004567 ATP binding site [chemical binding]; other site 1147128004568 Q-loop/lid; other site 1147128004569 ABC transporter signature motif; other site 1147128004570 Walker B; other site 1147128004571 D-loop; other site 1147128004572 H-loop/switch region; other site 1147128004573 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1147128004574 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1147128004575 DXD motif; other site 1147128004576 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1147128004577 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1147128004578 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1147128004579 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1147128004580 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1147128004581 active site 1147128004582 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 1147128004583 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1147128004584 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128004585 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128004586 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128004587 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128004588 DNA binding site [nucleotide binding] 1147128004589 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128004590 ligand binding site [chemical binding]; other site 1147128004591 dimerization interface [polypeptide binding]; other site 1147128004592 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128004593 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128004594 dimer interface [polypeptide binding]; other site 1147128004595 conserved gate region; other site 1147128004596 putative PBP binding loops; other site 1147128004597 ABC-ATPase subunit interface; other site 1147128004598 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1147128004599 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1147128004600 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128004601 dimer interface [polypeptide binding]; other site 1147128004602 putative PBP binding loops; other site 1147128004603 ABC-ATPase subunit interface; other site 1147128004604 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1147128004605 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1147128004606 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1147128004607 NAD(P) binding site [chemical binding]; other site 1147128004608 active site 1147128004609 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1147128004610 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1147128004611 active site 1147128004612 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1147128004613 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1147128004614 folate binding site [chemical binding]; other site 1147128004615 NADP+ binding site [chemical binding]; other site 1147128004616 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1147128004617 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1147128004618 dimerization interface [polypeptide binding]; other site 1147128004619 active site 1147128004620 OsmC-like protein; Region: OsmC; pfam02566 1147128004621 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1147128004622 Ligand Binding Site [chemical binding]; other site 1147128004623 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1147128004624 Ligand Binding Site [chemical binding]; other site 1147128004625 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1147128004626 NlpC/P60 family; Region: NLPC_P60; pfam00877 1147128004627 CHAP domain; Region: CHAP; pfam05257 1147128004628 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1147128004629 mannose-6-phosphate isomerase; Region: PLN02288 1147128004630 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1147128004631 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1147128004632 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128004633 ATP binding site [chemical binding]; other site 1147128004634 Mg2+ binding site [ion binding]; other site 1147128004635 G-X-G motif; other site 1147128004636 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1147128004637 PhoU domain; Region: PhoU; pfam01895 1147128004638 PhoU domain; Region: PhoU; pfam01895 1147128004639 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1147128004640 catalytic core [active] 1147128004641 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1147128004642 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1147128004643 UbiA prenyltransferase family; Region: UbiA; pfam01040 1147128004644 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 1147128004645 UbiA prenyltransferase family; Region: UbiA; pfam01040 1147128004646 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1147128004647 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1147128004648 dimer interface [polypeptide binding]; other site 1147128004649 putative anticodon binding site; other site 1147128004650 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1147128004651 motif 1; other site 1147128004652 dimer interface [polypeptide binding]; other site 1147128004653 active site 1147128004654 motif 2; other site 1147128004655 motif 3; other site 1147128004656 AAA domain; Region: AAA_21; pfam13304 1147128004657 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1147128004658 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1147128004659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1147128004660 binding surface 1147128004661 TPR motif; other site 1147128004662 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1147128004663 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 1147128004664 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 1147128004665 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1147128004666 PspC domain; Region: PspC; pfam04024 1147128004667 PspC domain; Region: PspC; pfam04024 1147128004668 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1147128004669 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1147128004670 Mg2+ binding site [ion binding]; other site 1147128004671 G-X-G motif; other site 1147128004672 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1147128004673 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128004674 active site 1147128004675 phosphorylation site [posttranslational modification] 1147128004676 intermolecular recognition site; other site 1147128004677 dimerization interface [polypeptide binding]; other site 1147128004678 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1147128004679 DNA binding residues [nucleotide binding] 1147128004680 dimerization interface [polypeptide binding]; other site 1147128004681 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1147128004682 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1147128004683 conserved cys residue [active] 1147128004684 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1147128004685 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1147128004686 Cl- selectivity filter; other site 1147128004687 Cl- binding residues [ion binding]; other site 1147128004688 pore gating glutamate residue; other site 1147128004689 dimer interface [polypeptide binding]; other site 1147128004690 H+/Cl- coupling transport residue; other site 1147128004691 TrkA-C domain; Region: TrkA_C; pfam02080 1147128004692 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 1147128004693 putative deacylase active site [active] 1147128004694 seryl-tRNA synthetase; Provisional; Region: PRK05431 1147128004695 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1147128004696 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1147128004697 dimer interface [polypeptide binding]; other site 1147128004698 active site 1147128004699 motif 1; other site 1147128004700 motif 2; other site 1147128004701 motif 3; other site 1147128004702 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1147128004703 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1147128004704 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1147128004705 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 1147128004706 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1147128004707 phosphoglucomutase; Validated; Region: PRK07564 1147128004708 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1147128004709 active site 1147128004710 substrate binding site [chemical binding]; other site 1147128004711 metal binding site [ion binding]; metal-binding site 1147128004712 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1147128004713 RNA/DNA hybrid binding site [nucleotide binding]; other site 1147128004714 active site 1147128004715 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1147128004716 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1147128004717 active site 1147128004718 dimer interface [polypeptide binding]; other site 1147128004719 DNA repair protein RadA; Provisional; Region: PRK11823 1147128004720 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1147128004721 Walker A motif; other site 1147128004722 ATP binding site [chemical binding]; other site 1147128004723 Walker B motif; other site 1147128004724 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1147128004725 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1147128004726 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1147128004727 substrate binding pocket [chemical binding]; other site 1147128004728 membrane-bound complex binding site; other site 1147128004729 hinge residues; other site 1147128004730 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1147128004731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128004732 dimer interface [polypeptide binding]; other site 1147128004733 conserved gate region; other site 1147128004734 putative PBP binding loops; other site 1147128004735 ABC-ATPase subunit interface; other site 1147128004736 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1147128004737 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1147128004738 Walker A/P-loop; other site 1147128004739 ATP binding site [chemical binding]; other site 1147128004740 Q-loop/lid; other site 1147128004741 ABC transporter signature motif; other site 1147128004742 Walker B; other site 1147128004743 D-loop; other site 1147128004744 H-loop/switch region; other site 1147128004745 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1147128004746 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1147128004747 active site 1147128004748 Riboflavin kinase; Region: Flavokinase; pfam01687 1147128004749 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 1147128004750 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1147128004751 RNA binding site [nucleotide binding]; other site 1147128004752 active site 1147128004753 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1147128004754 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1147128004755 translation initiation factor IF-2; Region: IF-2; TIGR00487 1147128004756 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1147128004757 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1147128004758 G1 box; other site 1147128004759 putative GEF interaction site [polypeptide binding]; other site 1147128004760 GTP/Mg2+ binding site [chemical binding]; other site 1147128004761 Switch I region; other site 1147128004762 G2 box; other site 1147128004763 G3 box; other site 1147128004764 Switch II region; other site 1147128004765 G4 box; other site 1147128004766 G5 box; other site 1147128004767 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1147128004768 Translation-initiation factor 2; Region: IF-2; pfam11987 1147128004769 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1147128004770 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1147128004771 NusA N-terminal domain; Region: NusA_N; pfam08529 1147128004772 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1147128004773 RNA binding site [nucleotide binding]; other site 1147128004774 homodimer interface [polypeptide binding]; other site 1147128004775 NusA-like KH domain; Region: KH_5; pfam13184 1147128004776 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1147128004777 G-X-X-G motif; other site 1147128004778 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1147128004779 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1147128004780 dimerization interface 3.5A [polypeptide binding]; other site 1147128004781 active site 1147128004782 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1147128004783 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1147128004784 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1147128004785 alphaNTD - beta interaction site [polypeptide binding]; other site 1147128004786 alphaNTD homodimer interface [polypeptide binding]; other site 1147128004787 alphaNTD - beta' interaction site [polypeptide binding]; other site 1147128004788 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1147128004789 30S ribosomal protein S11; Validated; Region: PRK05309 1147128004790 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1147128004791 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1147128004792 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 1147128004793 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1147128004794 rRNA binding site [nucleotide binding]; other site 1147128004795 predicted 30S ribosome binding site; other site 1147128004796 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 1147128004797 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1147128004798 putative dimer interface [polypeptide binding]; other site 1147128004799 glutamate dehydrogenase; Provisional; Region: PRK09414 1147128004800 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1147128004801 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1147128004802 NAD(P) binding site [chemical binding]; other site 1147128004803 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1147128004804 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1147128004805 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1147128004806 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1147128004807 TPR motif; other site 1147128004808 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1147128004809 binding surface 1147128004810 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1147128004811 binding surface 1147128004812 TPR motif; other site 1147128004813 TPR repeat; Region: TPR_11; pfam13414 1147128004814 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1147128004815 binding surface 1147128004816 TPR motif; other site 1147128004817 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128004818 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1147128004819 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1147128004820 Walker A/P-loop; other site 1147128004821 ATP binding site [chemical binding]; other site 1147128004822 Q-loop/lid; other site 1147128004823 ABC transporter signature motif; other site 1147128004824 Walker B; other site 1147128004825 D-loop; other site 1147128004826 H-loop/switch region; other site 1147128004827 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1147128004828 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1147128004829 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128004830 Walker A/P-loop; other site 1147128004831 ATP binding site [chemical binding]; other site 1147128004832 Q-loop/lid; other site 1147128004833 ABC transporter signature motif; other site 1147128004834 Walker B; other site 1147128004835 D-loop; other site 1147128004836 H-loop/switch region; other site 1147128004837 adenylate kinase; Reviewed; Region: adk; PRK00279 1147128004838 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1147128004839 AMP-binding site [chemical binding]; other site 1147128004840 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1147128004841 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1147128004842 SecY translocase; Region: SecY; pfam00344 1147128004843 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1147128004844 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1147128004845 23S rRNA binding site [nucleotide binding]; other site 1147128004846 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1147128004847 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1147128004848 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1147128004849 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1147128004850 23S rRNA interface [nucleotide binding]; other site 1147128004851 5S rRNA interface [nucleotide binding]; other site 1147128004852 L27 interface [polypeptide binding]; other site 1147128004853 L5 interface [polypeptide binding]; other site 1147128004854 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1147128004855 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1147128004856 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1147128004857 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1147128004858 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1147128004859 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1147128004860 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1147128004861 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1147128004862 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1147128004863 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1147128004864 RNA binding site [nucleotide binding]; other site 1147128004865 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1147128004866 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1147128004867 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1147128004868 23S rRNA interface [nucleotide binding]; other site 1147128004869 putative translocon interaction site; other site 1147128004870 signal recognition particle (SRP54) interaction site; other site 1147128004871 L23 interface [polypeptide binding]; other site 1147128004872 trigger factor interaction site; other site 1147128004873 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1147128004874 23S rRNA interface [nucleotide binding]; other site 1147128004875 5S rRNA interface [nucleotide binding]; other site 1147128004876 putative antibiotic binding site [chemical binding]; other site 1147128004877 L25 interface [polypeptide binding]; other site 1147128004878 L27 interface [polypeptide binding]; other site 1147128004879 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1147128004880 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1147128004881 G-X-X-G motif; other site 1147128004882 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1147128004883 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1147128004884 putative translocon binding site; other site 1147128004885 protein-rRNA interface [nucleotide binding]; other site 1147128004886 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1147128004887 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1147128004888 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1147128004889 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1147128004890 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1147128004891 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1147128004892 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1147128004893 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1147128004894 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1147128004895 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1147128004896 putative catalytic cysteine [active] 1147128004897 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1147128004898 putative active site [active] 1147128004899 metal binding site [ion binding]; metal-binding site 1147128004900 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1147128004901 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1147128004902 23S rRNA interface [nucleotide binding]; other site 1147128004903 L3 interface [polypeptide binding]; other site 1147128004904 HEAT repeats; Region: HEAT_2; pfam13646 1147128004905 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1147128004906 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1147128004907 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1147128004908 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1147128004909 active site 1147128004910 DNA polymerase IV; Validated; Region: PRK02406 1147128004911 DNA binding site [nucleotide binding] 1147128004912 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 1147128004913 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1147128004914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128004915 homodimer interface [polypeptide binding]; other site 1147128004916 catalytic residue [active] 1147128004917 Ferredoxin [Energy production and conversion]; Region: COG1146 1147128004918 4Fe-4S binding domain; Region: Fer4; cl02805 1147128004919 amino acid transporter; Region: 2A0306; TIGR00909 1147128004920 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1147128004921 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1147128004922 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1147128004923 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1147128004924 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 1147128004925 Interdomain contacts; other site 1147128004926 Cytokine receptor motif; other site 1147128004927 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 1147128004928 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 1147128004929 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1147128004930 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1147128004931 Pectinesterase; Region: Pectinesterase; pfam01095 1147128004932 putative pectinesterase; Region: PLN02432; cl01911 1147128004933 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 1147128004934 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 1147128004935 inhibitor binding site; inhibition site 1147128004936 active site 1147128004937 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128004938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128004939 dimer interface [polypeptide binding]; other site 1147128004940 conserved gate region; other site 1147128004941 putative PBP binding loops; other site 1147128004942 ABC-ATPase subunit interface; other site 1147128004943 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1147128004944 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128004945 dimer interface [polypeptide binding]; other site 1147128004946 conserved gate region; other site 1147128004947 putative PBP binding loops; other site 1147128004948 ABC-ATPase subunit interface; other site 1147128004949 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128004950 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 1147128004951 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128004952 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128004953 DNA binding site [nucleotide binding] 1147128004954 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 1147128004955 putative dimerization interface [polypeptide binding]; other site 1147128004956 putative ligand binding site [chemical binding]; other site 1147128004957 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1147128004958 Glucuronate isomerase; Region: UxaC; pfam02614 1147128004959 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128004960 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128004961 DNA binding site [nucleotide binding] 1147128004962 domain linker motif; other site 1147128004963 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128004964 dimerization interface [polypeptide binding]; other site 1147128004965 ligand binding site [chemical binding]; other site 1147128004966 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128004967 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128004968 DNA binding site [nucleotide binding] 1147128004969 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128004970 dimerization interface [polypeptide binding]; other site 1147128004971 ligand binding site [chemical binding]; other site 1147128004972 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1147128004973 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1147128004974 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1147128004975 mannonate dehydratase; Region: uxuA; TIGR00695 1147128004976 mannonate dehydratase; Provisional; Region: PRK03906 1147128004977 altronate oxidoreductase; Provisional; Region: PRK03643 1147128004978 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1147128004979 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1147128004980 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1147128004981 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1147128004982 active site 1147128004983 intersubunit interface [polypeptide binding]; other site 1147128004984 catalytic residue [active] 1147128004985 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1147128004986 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1147128004987 substrate binding site [chemical binding]; other site 1147128004988 ATP binding site [chemical binding]; other site 1147128004989 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 1147128004990 FAD binding domain; Region: FAD_binding_4; pfam01565 1147128004991 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1147128004992 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1147128004993 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1147128004994 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1147128004995 catalytic residue [active] 1147128004996 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1147128004997 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1147128004998 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1147128004999 dimer interface [polypeptide binding]; other site 1147128005000 putative radical transfer pathway; other site 1147128005001 diiron center [ion binding]; other site 1147128005002 tyrosyl radical; other site 1147128005003 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1147128005004 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1147128005005 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1147128005006 active site 1147128005007 dimer interface [polypeptide binding]; other site 1147128005008 catalytic residues [active] 1147128005009 effector binding site; other site 1147128005010 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1147128005011 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1147128005012 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1147128005013 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1147128005014 dimer interface [polypeptide binding]; other site 1147128005015 putative radical transfer pathway; other site 1147128005016 diiron center [ion binding]; other site 1147128005017 tyrosyl radical; other site 1147128005018 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1147128005019 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1147128005020 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1147128005021 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128005022 homodimer interface [polypeptide binding]; other site 1147128005023 catalytic residue [active] 1147128005024 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1147128005025 oligomerisation interface [polypeptide binding]; other site 1147128005026 mobile loop; other site 1147128005027 roof hairpin; other site 1147128005028 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1147128005029 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1147128005030 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1147128005031 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1147128005032 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 1147128005033 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1147128005034 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1147128005035 FHA domain; Region: FHA; pfam00498 1147128005036 phosphopeptide binding site; other site 1147128005037 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1147128005038 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1147128005039 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 1147128005040 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1147128005041 peripheral dimer interface [polypeptide binding]; other site 1147128005042 core dimer interface [polypeptide binding]; other site 1147128005043 L10 interface [polypeptide binding]; other site 1147128005044 L11 interface [polypeptide binding]; other site 1147128005045 putative EF-Tu interaction site [polypeptide binding]; other site 1147128005046 putative EF-G interaction site [polypeptide binding]; other site 1147128005047 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1147128005048 23S rRNA interface [nucleotide binding]; other site 1147128005049 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1147128005050 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1147128005051 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1147128005052 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128005053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128005054 dimer interface [polypeptide binding]; other site 1147128005055 conserved gate region; other site 1147128005056 putative PBP binding loops; other site 1147128005057 ABC-ATPase subunit interface; other site 1147128005058 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1147128005059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128005060 dimer interface [polypeptide binding]; other site 1147128005061 putative PBP binding loops; other site 1147128005062 ABC-ATPase subunit interface; other site 1147128005063 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128005064 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128005065 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 1147128005066 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128005067 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128005068 ligand binding site [chemical binding]; other site 1147128005069 dimerization interface [polypeptide binding]; other site 1147128005070 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1147128005071 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1147128005072 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1147128005073 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1147128005074 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1147128005075 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1147128005076 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1147128005077 trimer interface [polypeptide binding]; other site 1147128005078 active site 1147128005079 G bulge; other site 1147128005080 CAAX protease self-immunity; Region: Abi; pfam02517 1147128005081 DivIVA protein; Region: DivIVA; pfam05103 1147128005082 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1147128005083 Apolipophorin-III precursor (apoLp-III); Region: ApoLp-III; pfam07464 1147128005084 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1147128005085 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 1147128005086 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 1147128005087 putative substrate binding pocket [chemical binding]; other site 1147128005088 AC domain interface; other site 1147128005089 catalytic triad [active] 1147128005090 AB domain interface; other site 1147128005091 interchain disulfide; other site 1147128005092 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1147128005093 substrate binding site; other site 1147128005094 dimer interface; other site 1147128005095 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1147128005096 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 1147128005097 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1147128005098 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1147128005099 active site 1147128005100 catalytic tetrad [active] 1147128005101 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1147128005102 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1147128005103 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 1147128005104 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1147128005105 oligomer interface [polypeptide binding]; other site 1147128005106 RNA binding site [nucleotide binding]; other site 1147128005107 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1147128005108 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1147128005109 RNase E interface [polypeptide binding]; other site 1147128005110 trimer interface [polypeptide binding]; other site 1147128005111 active site 1147128005112 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1147128005113 putative nucleic acid binding region [nucleotide binding]; other site 1147128005114 G-X-X-G motif; other site 1147128005115 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1147128005116 RNA binding site [nucleotide binding]; other site 1147128005117 domain interface; other site 1147128005118 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1147128005119 16S/18S rRNA binding site [nucleotide binding]; other site 1147128005120 S13e-L30e interaction site [polypeptide binding]; other site 1147128005121 25S rRNA binding site [nucleotide binding]; other site 1147128005122 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 1147128005123 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1147128005124 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 1147128005125 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1147128005126 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1147128005127 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 1147128005128 CRISPR-associated protein Cse2 (CRISPR_cse2); Region: CRISPR_Cse2; pfam09485 1147128005129 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 1147128005130 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1147128005131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1147128005132 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1147128005133 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1147128005134 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1147128005135 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 1147128005136 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1147128005137 phosphate binding site [ion binding]; other site 1147128005138 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 1147128005139 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1147128005140 active site 2 [active] 1147128005141 active site 1 [active] 1147128005142 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1147128005143 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1147128005144 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 1147128005145 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 1147128005146 putative NAD(P) binding site [chemical binding]; other site 1147128005147 active site 1147128005148 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 1147128005149 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 1147128005150 active site 1147128005151 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 1147128005152 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1147128005153 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 1147128005154 Biotin carboxylase [Lipid metabolism]; Region: AccC; COG0439 1147128005155 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1147128005156 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1147128005157 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 1147128005158 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1147128005159 carboxyltransferase (CT) interaction site; other site 1147128005160 biotinylation site [posttranslational modification]; other site 1147128005161 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 1147128005162 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1147128005163 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1147128005164 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1147128005165 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1147128005166 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1147128005167 mRNA/rRNA interface [nucleotide binding]; other site 1147128005168 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1147128005169 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1147128005170 23S rRNA interface [nucleotide binding]; other site 1147128005171 L7/L12 interface [polypeptide binding]; other site 1147128005172 putative thiostrepton binding site; other site 1147128005173 L25 interface [polypeptide binding]; other site 1147128005174 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1147128005175 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1147128005176 putative homodimer interface [polypeptide binding]; other site 1147128005177 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1147128005178 heterodimer interface [polypeptide binding]; other site 1147128005179 homodimer interface [polypeptide binding]; other site 1147128005180 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 1147128005181 aspartate aminotransferase; Provisional; Region: PRK05764 1147128005182 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1147128005183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128005184 homodimer interface [polypeptide binding]; other site 1147128005185 catalytic residue [active] 1147128005186 gamma-glutamyl kinase; Provisional; Region: PRK05429 1147128005187 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1147128005188 nucleotide binding site [chemical binding]; other site 1147128005189 homotetrameric interface [polypeptide binding]; other site 1147128005190 putative phosphate binding site [ion binding]; other site 1147128005191 putative allosteric binding site; other site 1147128005192 PUA domain; Region: PUA; pfam01472 1147128005193 GTPase CgtA; Reviewed; Region: obgE; PRK12296 1147128005194 GTP1/OBG; Region: GTP1_OBG; pfam01018 1147128005195 Obg GTPase; Region: Obg; cd01898 1147128005196 G1 box; other site 1147128005197 GTP/Mg2+ binding site [chemical binding]; other site 1147128005198 Switch I region; other site 1147128005199 G2 box; other site 1147128005200 G3 box; other site 1147128005201 Switch II region; other site 1147128005202 G4 box; other site 1147128005203 G5 box; other site 1147128005204 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1147128005205 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1147128005206 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1147128005207 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1147128005208 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1147128005209 homodimer interface [polypeptide binding]; other site 1147128005210 oligonucleotide binding site [chemical binding]; other site 1147128005211 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 1147128005212 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 1147128005213 metal binding site [ion binding]; metal-binding site 1147128005214 putative dimer interface [polypeptide binding]; other site 1147128005215 Predicted permeases [General function prediction only]; Region: COG0679 1147128005216 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1147128005217 active site 1147128005218 dimer interface [polypeptide binding]; other site 1147128005219 NUDIX domain; Region: NUDIX; pfam00293 1147128005220 nudix motif; other site 1147128005221 homoserine kinase; Provisional; Region: PRK01212 1147128005222 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1147128005223 homoserine dehydrogenase; Provisional; Region: PRK06349 1147128005224 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1147128005225 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1147128005226 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1147128005227 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1147128005228 catalytic residue [active] 1147128005229 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1147128005230 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1147128005231 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1147128005232 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 1147128005233 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1147128005234 active site 1147128005235 HIGH motif; other site 1147128005236 nucleotide binding site [chemical binding]; other site 1147128005237 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1147128005238 KMSK motif region; other site 1147128005239 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1147128005240 tRNA binding surface [nucleotide binding]; other site 1147128005241 anticodon binding site; other site 1147128005242 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1147128005243 homotrimer interaction site [polypeptide binding]; other site 1147128005244 putative active site [active] 1147128005245 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1147128005246 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1147128005247 PYR/PP interface [polypeptide binding]; other site 1147128005248 dimer interface [polypeptide binding]; other site 1147128005249 tetramer interface [polypeptide binding]; other site 1147128005250 TPP binding site [chemical binding]; other site 1147128005251 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1147128005252 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1147128005253 TPP-binding site [chemical binding]; other site 1147128005254 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 1147128005255 putative dimer interface [polypeptide binding]; other site 1147128005256 putative active site [active] 1147128005257 putative phosphate binding site [ion binding]; other site 1147128005258 putative metal binding residues [ion binding]; other site 1147128005259 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1147128005260 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1147128005261 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1147128005262 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1147128005263 substrate binding pocket [chemical binding]; other site 1147128005264 membrane-bound complex binding site; other site 1147128005265 hinge residues; other site 1147128005266 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1147128005267 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1147128005268 Walker A/P-loop; other site 1147128005269 ATP binding site [chemical binding]; other site 1147128005270 Q-loop/lid; other site 1147128005271 ABC transporter signature motif; other site 1147128005272 Walker B; other site 1147128005273 D-loop; other site 1147128005274 H-loop/switch region; other site 1147128005275 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1147128005276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128005277 dimer interface [polypeptide binding]; other site 1147128005278 conserved gate region; other site 1147128005279 putative PBP binding loops; other site 1147128005280 ABC-ATPase subunit interface; other site 1147128005281 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128005282 dimer interface [polypeptide binding]; other site 1147128005283 conserved gate region; other site 1147128005284 putative PBP binding loops; other site 1147128005285 ABC-ATPase subunit interface; other site 1147128005286 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1147128005287 catalytic residues [active] 1147128005288 hypothetical protein; Provisional; Region: PRK03298 1147128005289 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1147128005290 gamma subunit interface [polypeptide binding]; other site 1147128005291 LBP interface [polypeptide binding]; other site 1147128005292 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1147128005293 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1147128005294 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1147128005295 alpha subunit interaction interface [polypeptide binding]; other site 1147128005296 Walker A motif; other site 1147128005297 ATP binding site [chemical binding]; other site 1147128005298 Walker B motif; other site 1147128005299 inhibitor binding site; inhibition site 1147128005300 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1147128005301 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1147128005302 core domain interface [polypeptide binding]; other site 1147128005303 delta subunit interface [polypeptide binding]; other site 1147128005304 epsilon subunit interface [polypeptide binding]; other site 1147128005305 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1147128005306 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1147128005307 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1147128005308 beta subunit interaction interface [polypeptide binding]; other site 1147128005309 Walker A motif; other site 1147128005310 ATP binding site [chemical binding]; other site 1147128005311 Walker B motif; other site 1147128005312 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1147128005313 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 1147128005314 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1147128005315 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1147128005316 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1147128005317 ATP synthase subunit C; Region: ATP-synt_C; cl00466 1147128005318 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1147128005319 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1147128005320 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1147128005321 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1147128005322 proposed active site lysine [active] 1147128005323 conserved cys residue [active] 1147128005324 Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117 1147128005325 PLD-like domain; Region: PLDc_2; pfam13091 1147128005326 homodimer interface [polypeptide binding]; other site 1147128005327 putative active site [active] 1147128005328 catalytic site [active] 1147128005329 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 1147128005330 RelB antitoxin; Region: RelB; cl01171 1147128005331 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 1147128005332 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1147128005333 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1147128005334 active site 1147128005335 catalytic tetrad [active] 1147128005336 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128005337 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128005338 DNA binding site [nucleotide binding] 1147128005339 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128005340 ligand binding site [chemical binding]; other site 1147128005341 dimerization interface [polypeptide binding]; other site 1147128005342 Glycosyl hydrolase family 67 N-terminus; Region: Glyco_hydro_67N; pfam03648 1147128005343 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 1147128005344 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1147128005345 dimer interface [polypeptide binding]; other site 1147128005346 substrate binding site [chemical binding]; other site 1147128005347 metal binding sites [ion binding]; metal-binding site 1147128005348 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1147128005349 Predicted membrane protein [Function unknown]; Region: COG2323 1147128005350 Predicted membrane protein [Function unknown]; Region: COG1971 1147128005351 Domain of unknown function DUF; Region: DUF204; pfam02659 1147128005352 Domain of unknown function DUF; Region: DUF204; pfam02659 1147128005353 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1147128005354 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1147128005355 DNA binding site [nucleotide binding] 1147128005356 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1147128005357 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1147128005358 minor groove reading motif; other site 1147128005359 helix-hairpin-helix signature motif; other site 1147128005360 substrate binding pocket [chemical binding]; other site 1147128005361 active site 1147128005362 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 1147128005363 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1147128005364 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1147128005365 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 1147128005366 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1147128005367 active site 1147128005368 HIGH motif; other site 1147128005369 nucleotide binding site [chemical binding]; other site 1147128005370 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1147128005371 active site 1147128005372 KMSKS motif; other site 1147128005373 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1147128005374 tRNA binding surface [nucleotide binding]; other site 1147128005375 anticodon binding site; other site 1147128005376 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 1147128005377 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128005378 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005379 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005380 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128005381 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005382 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005383 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; cl09714 1147128005384 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128005385 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005386 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128005387 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005388 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005389 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005390 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005391 Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479 1147128005392 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128005393 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005394 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1_2; pfam13540 1147128005395 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005396 Regulator of chromosome condensation (RCC1) repeat; Region: RCC1; pfam00415 1147128005397 Chorismate mutase type II; Region: CM_2; cl00693 1147128005398 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1147128005399 transcription termination factor Rho; Provisional; Region: PRK12608 1147128005400 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1147128005401 RNA binding site [nucleotide binding]; other site 1147128005402 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1147128005403 Walker A motif; other site 1147128005404 ATP binding site [chemical binding]; other site 1147128005405 Walker B motif; other site 1147128005406 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1147128005407 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1147128005408 hypothetical protein; Provisional; Region: PRK07208 1147128005409 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1147128005410 UDP-galactopyranose mutase; Region: GLF; pfam03275 1147128005411 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 1147128005412 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1147128005413 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1147128005414 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1147128005415 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1147128005416 GatB domain; Region: GatB_Yqey; pfam02637 1147128005417 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1147128005418 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1147128005419 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1147128005420 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1147128005421 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128005422 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128005423 Walker A/P-loop; other site 1147128005424 ATP binding site [chemical binding]; other site 1147128005425 Q-loop/lid; other site 1147128005426 ABC transporter signature motif; other site 1147128005427 Walker B; other site 1147128005428 D-loop; other site 1147128005429 H-loop/switch region; other site 1147128005430 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1147128005431 RmuC family; Region: RmuC; pfam02646 1147128005432 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1147128005433 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1147128005434 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1147128005435 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1147128005436 Clp amino terminal domain; Region: Clp_N; pfam02861 1147128005437 Clp amino terminal domain; Region: Clp_N; pfam02861 1147128005438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128005439 Walker A motif; other site 1147128005440 ATP binding site [chemical binding]; other site 1147128005441 Walker B motif; other site 1147128005442 arginine finger; other site 1147128005443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128005444 Walker A motif; other site 1147128005445 ATP binding site [chemical binding]; other site 1147128005446 Walker B motif; other site 1147128005447 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1147128005448 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 1147128005449 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1147128005450 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1147128005451 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1147128005452 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1147128005453 catalytic residue [active] 1147128005454 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1147128005455 active site 1147128005456 HIGH motif; other site 1147128005457 nucleotide binding site [chemical binding]; other site 1147128005458 active site 1147128005459 KMSKS motif; other site 1147128005460 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 1147128005461 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 1147128005462 active site 1147128005463 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1147128005464 amphipathic channel; other site 1147128005465 Asn-Pro-Ala signature motifs; other site 1147128005466 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1147128005467 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 1147128005468 Peptidase family C69; Region: Peptidase_C69; pfam03577 1147128005469 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1147128005470 substrate binding site [chemical binding]; other site 1147128005471 DNA polymerase III subunit delta'; Validated; Region: PRK07940 1147128005472 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1147128005473 thymidylate kinase; Validated; Region: tmk; PRK00698 1147128005474 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1147128005475 TMP-binding site; other site 1147128005476 ATP-binding site [chemical binding]; other site 1147128005477 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1147128005478 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1147128005479 active site 1147128005480 interdomain interaction site; other site 1147128005481 putative metal-binding site [ion binding]; other site 1147128005482 nucleotide binding site [chemical binding]; other site 1147128005483 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1147128005484 domain I; other site 1147128005485 phosphate binding site [ion binding]; other site 1147128005486 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1147128005487 domain II; other site 1147128005488 domain III; other site 1147128005489 nucleotide binding site [chemical binding]; other site 1147128005490 DNA binding groove [nucleotide binding] 1147128005491 catalytic site [active] 1147128005492 domain IV; other site 1147128005493 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1147128005494 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 1147128005495 PAP2 superfamily; Region: PAP2; pfam01569 1147128005496 active site 1147128005497 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 1147128005498 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1147128005499 UDP-galactopyranose mutase; Region: GLF; pfam03275 1147128005500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1147128005501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1147128005502 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128005503 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128005504 putative substrate translocation pore; other site 1147128005505 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 1147128005506 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 1147128005507 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 1147128005508 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 1147128005509 Transglycosylase; Region: Transgly; pfam00912 1147128005510 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1147128005511 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1147128005512 2-isopropylmalate synthase; Validated; Region: PRK03739 1147128005513 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 1147128005514 active site 1147128005515 catalytic residues [active] 1147128005516 metal binding site [ion binding]; metal-binding site 1147128005517 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1147128005518 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1147128005519 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1147128005520 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 1147128005521 putative allosteric regulatory site; other site 1147128005522 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 1147128005523 aspartate kinase; Reviewed; Region: PRK06635 1147128005524 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 1147128005525 putative nucleotide binding site [chemical binding]; other site 1147128005526 putative catalytic residues [active] 1147128005527 putative Mg ion binding site [ion binding]; other site 1147128005528 putative aspartate binding site [chemical binding]; other site 1147128005529 recombination protein RecR; Reviewed; Region: recR; PRK00076 1147128005530 RecR protein; Region: RecR; pfam02132 1147128005531 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1147128005532 putative active site [active] 1147128005533 putative metal-binding site [ion binding]; other site 1147128005534 tetramer interface [polypeptide binding]; other site 1147128005535 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 1147128005536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1147128005537 Walker A motif; other site 1147128005538 ATP binding site [chemical binding]; other site 1147128005539 Walker B motif; other site 1147128005540 arginine finger; other site 1147128005541 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1147128005542 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 1147128005543 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 1147128005544 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1147128005545 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 1147128005546 Walker B motif; other site 1147128005547 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 1147128005548 polyphosphate kinase; Provisional; Region: PRK05443 1147128005549 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1147128005550 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1147128005551 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1147128005552 putative domain interface [polypeptide binding]; other site 1147128005553 putative active site [active] 1147128005554 catalytic site [active] 1147128005555 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1147128005556 putative domain interface [polypeptide binding]; other site 1147128005557 putative active site [active] 1147128005558 catalytic site [active] 1147128005559 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1147128005560 active site 1147128005561 Ap6A binding site [chemical binding]; other site 1147128005562 nudix motif; other site 1147128005563 metal binding site [ion binding]; metal-binding site 1147128005564 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1147128005565 catalytic core [active] 1147128005566 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1147128005567 active site 1147128005568 FtsX-like permease family; Region: FtsX; pfam02687 1147128005569 FtsX-like permease family; Region: FtsX; pfam02687 1147128005570 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 1147128005571 active site 1147128005572 catalytic site [active] 1147128005573 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1147128005574 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1147128005575 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1147128005576 active site 1147128005577 catalytic tetrad [active] 1147128005578 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1147128005579 ABC1 family; Region: ABC1; cl17513 1147128005580 Uncharacterized conserved protein [Function unknown]; Region: COG3937 1147128005581 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1147128005582 catalytic triad [active] 1147128005583 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1147128005584 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1147128005585 replicative DNA helicase; Region: DnaB; TIGR00665 1147128005586 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1147128005587 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1147128005588 Walker A motif; other site 1147128005589 ATP binding site [chemical binding]; other site 1147128005590 Walker B motif; other site 1147128005591 DNA binding loops [nucleotide binding] 1147128005592 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1147128005593 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1147128005594 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1147128005595 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1147128005596 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 1147128005597 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1147128005598 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1147128005599 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1147128005600 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1147128005601 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1147128005602 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1147128005603 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1147128005604 Walker A/P-loop; other site 1147128005605 ATP binding site [chemical binding]; other site 1147128005606 Q-loop/lid; other site 1147128005607 ABC transporter signature motif; other site 1147128005608 Walker B; other site 1147128005609 D-loop; other site 1147128005610 H-loop/switch region; other site 1147128005611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1147128005612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1147128005613 Coenzyme A binding pocket [chemical binding]; other site 1147128005614 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1147128005615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128005616 active site 1147128005617 phosphorylation site [posttranslational modification] 1147128005618 intermolecular recognition site; other site 1147128005619 dimerization interface [polypeptide binding]; other site 1147128005620 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1147128005621 DNA binding residues [nucleotide binding] 1147128005622 dimerization interface [polypeptide binding]; other site 1147128005623 Histidine kinase; Region: HisKA_3; pfam07730 1147128005624 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1147128005625 ATP binding site [chemical binding]; other site 1147128005626 Mg2+ binding site [ion binding]; other site 1147128005627 G-X-G motif; other site 1147128005628 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128005629 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128005630 Walker A/P-loop; other site 1147128005631 ATP binding site [chemical binding]; other site 1147128005632 Q-loop/lid; other site 1147128005633 ABC transporter signature motif; other site 1147128005634 Walker B; other site 1147128005635 D-loop; other site 1147128005636 H-loop/switch region; other site 1147128005637 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128005638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1147128005639 Walker A/P-loop; other site 1147128005640 ATP binding site [chemical binding]; other site 1147128005641 Q-loop/lid; other site 1147128005642 ABC transporter signature motif; other site 1147128005643 Walker B; other site 1147128005644 D-loop; other site 1147128005645 H-loop/switch region; other site 1147128005646 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 1147128005647 RelB antitoxin; Region: RelB; cl01171 1147128005648 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1147128005649 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1147128005650 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1147128005651 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1147128005652 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1147128005653 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1147128005654 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1147128005655 HAMP domain; Region: HAMP; pfam00672 1147128005656 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1147128005657 dimer interface [polypeptide binding]; other site 1147128005658 phosphorylation site [posttranslational modification] 1147128005659 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1147128005660 ATP binding site [chemical binding]; other site 1147128005661 Mg2+ binding site [ion binding]; other site 1147128005662 G-X-G motif; other site 1147128005663 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1147128005664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1147128005665 active site 1147128005666 phosphorylation site [posttranslational modification] 1147128005667 intermolecular recognition site; other site 1147128005668 dimerization interface [polypeptide binding]; other site 1147128005669 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1147128005670 DNA binding site [nucleotide binding] 1147128005671 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 1147128005672 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 1147128005673 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1147128005674 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1147128005675 Walker A/P-loop; other site 1147128005676 ATP binding site [chemical binding]; other site 1147128005677 Q-loop/lid; other site 1147128005678 ABC transporter signature motif; other site 1147128005679 Walker B; other site 1147128005680 D-loop; other site 1147128005681 H-loop/switch region; other site 1147128005682 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1147128005683 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1147128005684 siderophore binding site; other site 1147128005685 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1147128005686 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1147128005687 ABC-ATPase subunit interface; other site 1147128005688 dimer interface [polypeptide binding]; other site 1147128005689 putative PBP binding regions; other site 1147128005690 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1147128005691 ABC-ATPase subunit interface; other site 1147128005692 dimer interface [polypeptide binding]; other site 1147128005693 putative PBP binding regions; other site 1147128005694 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1147128005695 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1147128005696 Walker A/P-loop; other site 1147128005697 ATP binding site [chemical binding]; other site 1147128005698 Q-loop/lid; other site 1147128005699 ABC transporter signature motif; other site 1147128005700 Walker B; other site 1147128005701 D-loop; other site 1147128005702 H-loop/switch region; other site 1147128005703 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1147128005704 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1147128005705 FAD binding pocket [chemical binding]; other site 1147128005706 FAD binding motif [chemical binding]; other site 1147128005707 phosphate binding motif [ion binding]; other site 1147128005708 NAD binding pocket [chemical binding]; other site 1147128005709 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1147128005710 Glutamine amidotransferase class-I; Region: GATase; pfam00117 1147128005711 glutamine binding [chemical binding]; other site 1147128005712 catalytic triad [active] 1147128005713 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 1147128005714 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1147128005715 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1147128005716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128005717 putative substrate translocation pore; other site 1147128005718 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1147128005719 active site 1147128005720 tetramer interface [polypeptide binding]; other site 1147128005721 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1147128005722 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1147128005723 Walker A/P-loop; other site 1147128005724 ATP binding site [chemical binding]; other site 1147128005725 Q-loop/lid; other site 1147128005726 ABC transporter signature motif; other site 1147128005727 Walker B; other site 1147128005728 D-loop; other site 1147128005729 H-loop/switch region; other site 1147128005730 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 1147128005731 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1147128005732 Walker A/P-loop; other site 1147128005733 ATP binding site [chemical binding]; other site 1147128005734 Q-loop/lid; other site 1147128005735 ABC transporter signature motif; other site 1147128005736 Walker B; other site 1147128005737 D-loop; other site 1147128005738 H-loop/switch region; other site 1147128005739 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1147128005740 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1147128005741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128005742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128005743 DNA binding site [nucleotide binding] 1147128005744 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128005745 ligand binding site [chemical binding]; other site 1147128005746 dimerization interface [polypeptide binding]; other site 1147128005747 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1147128005748 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1147128005749 substrate binding site [chemical binding]; other site 1147128005750 dimer interface [polypeptide binding]; other site 1147128005751 ATP binding site [chemical binding]; other site 1147128005752 putative alpha-glucosidase; Provisional; Region: PRK10658 1147128005753 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1147128005754 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 1147128005755 putative active site [active] 1147128005756 putative catalytic site [active] 1147128005757 Domain of unknown function (DUF955); Region: DUF955; cl01076 1147128005758 Domain of unknown function (DUF4411); Region: DUF4411; pfam14367 1147128005759 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1147128005760 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1147128005761 active site 1147128005762 metal binding site [ion binding]; metal-binding site 1147128005763 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK08293 1147128005764 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1147128005765 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1147128005766 Membrane protease subunit, stomatin/prohibitin family [Amino acid transport and metabolism]; Region: COG4260 1147128005767 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1147128005768 Short C-terminal domain; Region: SHOCT; pfam09851 1147128005769 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 1147128005770 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1147128005771 Double zinc ribbon; Region: DZR; pfam12773 1147128005772 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1147128005773 TPR motif; other site 1147128005774 TPR repeat; Region: TPR_11; pfam13414 1147128005775 binding surface 1147128005776 Short repeat of unknown function (DUF308); Region: DUF308; cl15828 1147128005777 proline/glycine betaine transporter; Provisional; Region: PRK10642 1147128005778 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128005779 putative substrate translocation pore; other site 1147128005780 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1147128005781 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 1147128005782 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1147128005783 S-adenosylmethionine binding site [chemical binding]; other site 1147128005784 FMN-binding domain; Region: FMN_bind; cl01081 1147128005785 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1147128005786 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1147128005787 Walker A/P-loop; other site 1147128005788 ATP binding site [chemical binding]; other site 1147128005789 Q-loop/lid; other site 1147128005790 ABC transporter signature motif; other site 1147128005791 Walker B; other site 1147128005792 D-loop; other site 1147128005793 H-loop/switch region; other site 1147128005794 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1147128005795 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1147128005796 FtsX-like permease family; Region: FtsX; pfam02687 1147128005797 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1147128005798 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1147128005799 Predicted membrane protein [Function unknown]; Region: COG4393 1147128005800 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 1147128005801 Fe2+ transport protein; Region: Iron_transport; pfam10634 1147128005802 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1147128005803 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1147128005804 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1147128005805 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 1147128005806 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1147128005807 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1147128005808 lysine transporter; Provisional; Region: PRK10836 1147128005809 lysine transporter; Provisional; Region: PRK10836 1147128005810 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1147128005811 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1147128005812 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1147128005813 sucrose phosphorylase; Provisional; Region: PRK13840 1147128005814 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 1147128005815 active site 1147128005816 homodimer interface [polypeptide binding]; other site 1147128005817 catalytic site [active] 1147128005818 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 1147128005819 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128005820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128005821 DNA binding site [nucleotide binding] 1147128005822 domain linker motif; other site 1147128005823 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128005824 ligand binding site [chemical binding]; other site 1147128005825 dimerization interface [polypeptide binding]; other site 1147128005826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128005827 metabolite-proton symporter; Region: 2A0106; TIGR00883 1147128005828 putative substrate translocation pore; other site 1147128005829 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 1147128005830 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 1147128005831 active site 1147128005832 catalytic site [active] 1147128005833 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1147128005834 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128005835 dimer interface [polypeptide binding]; other site 1147128005836 conserved gate region; other site 1147128005837 putative PBP binding loops; other site 1147128005838 ABC-ATPase subunit interface; other site 1147128005839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1147128005840 dimer interface [polypeptide binding]; other site 1147128005841 conserved gate region; other site 1147128005842 putative PBP binding loops; other site 1147128005843 ABC-ATPase subunit interface; other site 1147128005844 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1147128005845 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1147128005846 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128005847 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128005848 DNA binding site [nucleotide binding] 1147128005849 domain linker motif; other site 1147128005850 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128005851 ligand binding site [chemical binding]; other site 1147128005852 dimerization interface [polypeptide binding]; other site 1147128005853 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1147128005854 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1147128005855 GDP-binding site [chemical binding]; other site 1147128005856 ACT binding site; other site 1147128005857 IMP binding site; other site 1147128005858 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1147128005859 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1147128005860 active site 1147128005861 intersubunit interface [polypeptide binding]; other site 1147128005862 zinc binding site [ion binding]; other site 1147128005863 Na+ binding site [ion binding]; other site 1147128005864 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 1147128005865 active site 1147128005866 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1147128005867 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1147128005868 putative substrate translocation pore; other site 1147128005869 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1147128005870 trimer interface [polypeptide binding]; other site 1147128005871 active site 1147128005872 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1147128005873 MFS/sugar transport protein; Region: MFS_2; pfam13347 1147128005874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1147128005875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1147128005876 DNA binding site [nucleotide binding] 1147128005877 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1147128005878 dimerization interface [polypeptide binding]; other site 1147128005879 ligand binding site [chemical binding]; other site 1147128005880 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1147128005881 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 1147128005882 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1147128005883 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1147128005884 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1147128005885 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1147128005886 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1147128005887 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1147128005888 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 1147128005889 Bacterial protein of unknown function (HtrL_YibB); Region: HtrL_YibB; cl08171 1147128005890 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1147128005891 active site 1147128005892 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1147128005893 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1147128005894 active site 1147128005895 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 1147128005896 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 1147128005897 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1147128005898 putative ADP-binding pocket [chemical binding]; other site 1147128005899 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 1147128005900 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 1147128005901 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1147128005902 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 1147128005903 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1147128005904 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1147128005905 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1147128005906 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 1147128005907 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1147128005908 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1147128005909 Walker A/P-loop; other site 1147128005910 ATP binding site [chemical binding]; other site 1147128005911 Q-loop/lid; other site 1147128005912 ABC transporter signature motif; other site 1147128005913 Walker B; other site 1147128005914 D-loop; other site 1147128005915 H-loop/switch region; other site 1147128005916 TOBE domain; Region: TOBE_2; pfam08402 1147128005917 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 1147128005918 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1147128005919 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1147128005920 active site 1147128005921 ATP binding site [chemical binding]; other site 1147128005922 substrate binding site [chemical binding]; other site 1147128005923 activation loop (A-loop); other site 1147128005924 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 1147128005925 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 1147128005926 catalytic residues [active] 1147128005927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 1147128005928 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1147128005929 Domain of unknown function (DUF348); Region: DUF348; pfam03990 1147128005930 G5 domain; Region: G5; pfam07501 1147128005931 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1147128005932 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1147128005933 catalytic residue [active] 1147128005934 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1147128005935 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1147128005936 4-diphosphocytidyl-2C-methyl-D-erythritol kinase; Region: ispE; TIGR00154 1147128005937 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1147128005938 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1147128005939 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 1147128005940 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1147128005941 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 1147128005942 active site 1147128005943 NTP binding site [chemical binding]; other site 1147128005944 metal binding triad [ion binding]; metal-binding site 1147128005945 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1147128005946 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1147128005947 Zn2+ binding site [ion binding]; other site 1147128005948 Mg2+ binding site [ion binding]; other site 1147128005949 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 1147128005950 active site 1147128005951 Ap6A binding site [chemical binding]; other site 1147128005952 nudix motif; other site 1147128005953 metal binding site [ion binding]; metal-binding site 1147128005954 integral membrane protein MviN; Region: mviN; TIGR01695 1147128005955 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1147128005956 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 1147128005957 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1147128005958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1147128005959 homodimer interface [polypeptide binding]; other site 1147128005960 catalytic residue [active] 1147128005961 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1147128005962 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1147128005963 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1147128005964 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1147128005965 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1147128005966 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1147128005967 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1147128005968 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1147128005969 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1147128005970 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 1147128005971 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1147128005972 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1147128005973 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1147128005974 ATP binding site [chemical binding]; other site 1147128005975 putative Mg++ binding site [ion binding]; other site 1147128005976 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1147128005977 Protein of unknown function DUF262; Region: DUF262; pfam03235 1147128005978 Protein of unknown function DUF262; Region: DUF262; pfam03235 1147128005979 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1147128005980 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1147128005981 ParB-like nuclease domain; Region: ParBc; pfam02195 1147128005982 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1147128005983 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1147128005984 P-loop; other site 1147128005985 Magnesium ion binding site [ion binding]; other site 1147128005986 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1147128005987 Magnesium ion binding site [ion binding]; other site 1147128005988 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1147128005989 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 1147128005990 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; cl17726 1147128005991 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1147128005992 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1147128005993 G-X-X-G motif; other site 1147128005994 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1147128005995 RxxxH motif; other site 1147128005996 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 1147128005997 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1147128005998 Haemolytic domain; Region: Haemolytic; cl00506 1147128005999 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1147128006000 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399