-- dump date 20140619_002305 -- class Genbank::misc_feature -- table misc_feature_note -- id note 484020000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 484020000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020000003 Walker A motif; other site 484020000004 ATP binding site [chemical binding]; other site 484020000005 Walker B motif; other site 484020000006 arginine finger; other site 484020000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 484020000008 DnaA box-binding interface [nucleotide binding]; other site 484020000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 484020000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 484020000011 putative DNA binding surface [nucleotide binding]; other site 484020000012 dimer interface [polypeptide binding]; other site 484020000013 beta-clamp/clamp loader binding surface; other site 484020000014 beta-clamp/translesion DNA polymerase binding surface; other site 484020000015 recombination protein F; Reviewed; Region: recF; PRK00064 484020000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020000017 Walker A/P-loop; other site 484020000018 ATP binding site [chemical binding]; other site 484020000019 Q-loop/lid; other site 484020000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020000021 ABC transporter signature motif; other site 484020000022 Walker B; other site 484020000023 D-loop; other site 484020000024 H-loop/switch region; other site 484020000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 484020000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 484020000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020000028 Mg2+ binding site [ion binding]; other site 484020000029 G-X-G motif; other site 484020000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 484020000031 anchoring element; other site 484020000032 dimer interface [polypeptide binding]; other site 484020000033 ATP binding site [chemical binding]; other site 484020000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 484020000035 active site 484020000036 putative metal-binding site [ion binding]; other site 484020000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 484020000038 DNA gyrase subunit A; Validated; Region: PRK05560 484020000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 484020000040 CAP-like domain; other site 484020000041 active site 484020000042 primary dimer interface [polypeptide binding]; other site 484020000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484020000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484020000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484020000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484020000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 484020000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 484020000049 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 484020000050 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 484020000051 active site 484020000052 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020000053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020000054 DNA binding site [nucleotide binding] 484020000055 domain linker motif; other site 484020000056 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484020000057 dimerization interface [polypeptide binding]; other site 484020000058 ligand binding site [chemical binding]; other site 484020000059 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 484020000060 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 484020000061 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 484020000062 glutamate dehydrogenase; Provisional; Region: PRK09414 484020000063 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 484020000064 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 484020000065 NAD(P) binding site [chemical binding]; other site 484020000066 Transcriptional regulators [Transcription]; Region: FadR; COG2186 484020000067 FCD domain; Region: FCD; pfam07729 484020000068 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 484020000069 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 484020000070 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 484020000071 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 484020000072 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 484020000073 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 484020000074 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 484020000075 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 484020000076 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 484020000077 putative active site [active] 484020000078 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020000079 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020000080 DNA binding site [nucleotide binding] 484020000081 domain linker motif; other site 484020000082 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484020000083 ligand binding site [chemical binding]; other site 484020000084 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 484020000085 active site 484020000086 phosphorylation site [posttranslational modification] 484020000087 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 484020000088 active site 484020000089 P-loop; other site 484020000090 phosphorylation site [posttranslational modification] 484020000091 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 484020000092 Protein of unknown function DUF45; Region: DUF45; pfam01863 484020000093 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 484020000094 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 484020000095 dimerization interface [polypeptide binding]; other site 484020000096 DPS ferroxidase diiron center [ion binding]; other site 484020000097 ion pore; other site 484020000098 aromatic amino acid exporter; Provisional; Region: PRK11689 484020000099 EamA-like transporter family; Region: EamA; pfam00892 484020000100 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 484020000101 Domain of unknown function DUF21; Region: DUF21; pfam01595 484020000102 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484020000103 Transporter associated domain; Region: CorC_HlyC; smart01091 484020000104 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020000105 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020000106 DNA binding site [nucleotide binding] 484020000107 domain linker motif; other site 484020000108 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484020000109 dimerization interface [polypeptide binding]; other site 484020000110 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 484020000111 active site clefts [active] 484020000112 zinc binding site [ion binding]; other site 484020000113 dimer interface [polypeptide binding]; other site 484020000114 peroxiredoxin; Region: AhpC; TIGR03137 484020000115 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 484020000116 dimer interface [polypeptide binding]; other site 484020000117 decamer (pentamer of dimers) interface [polypeptide binding]; other site 484020000118 catalytic triad [active] 484020000119 peroxidatic and resolving cysteines [active] 484020000120 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 484020000121 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484020000122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484020000123 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 484020000124 catalytic residue [active] 484020000125 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484020000126 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 484020000127 Divergent AAA domain; Region: AAA_4; pfam04326 484020000128 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 484020000129 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 484020000130 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020000131 putative substrate translocation pore; other site 484020000132 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 484020000133 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 484020000134 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 484020000135 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 484020000136 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 484020000137 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484020000138 active site 484020000139 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 484020000140 putative active site [active] 484020000141 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 484020000142 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 484020000143 active site 484020000144 HIGH motif; other site 484020000145 dimer interface [polypeptide binding]; other site 484020000146 KMSKS motif; other site 484020000147 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 484020000148 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020000149 active site 484020000150 phosphorylation site [posttranslational modification] 484020000151 intermolecular recognition site; other site 484020000152 dimerization interface [polypeptide binding]; other site 484020000153 LytTr DNA-binding domain; Region: LytTR; smart00850 484020000154 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 484020000155 ATP binding site [chemical binding]; other site 484020000156 Mg2+ binding site [ion binding]; other site 484020000157 G-X-G motif; other site 484020000158 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 484020000159 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 484020000160 NAD binding site [chemical binding]; other site 484020000161 substrate binding site [chemical binding]; other site 484020000162 homodimer interface [polypeptide binding]; other site 484020000163 active site 484020000164 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 484020000165 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 484020000166 active site 484020000167 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 484020000168 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 484020000169 putative sugar binding sites [chemical binding]; other site 484020000170 Q-X-W motif; other site 484020000171 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 484020000172 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 484020000173 putative sugar binding sites [chemical binding]; other site 484020000174 Q-X-W motif; other site 484020000175 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 484020000176 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 484020000177 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 484020000178 Ricin-type beta-trefoil; Region: RICIN; smart00458 484020000179 putative sugar binding sites [chemical binding]; other site 484020000180 Q-X-W motif; other site 484020000181 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 484020000182 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 484020000183 Ligand binding site; other site 484020000184 Putative Catalytic site; other site 484020000185 DXD motif; other site 484020000186 Acyltransferase family; Region: Acyl_transf_3; pfam01757 484020000187 Transposase; Region: DEDD_Tnp_IS110; pfam01548 484020000188 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 484020000189 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 484020000190 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484020000191 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020000192 non-specific DNA binding site [nucleotide binding]; other site 484020000193 salt bridge; other site 484020000194 sequence-specific DNA binding site [nucleotide binding]; other site 484020000195 potential frameshift: common BLAST hit: gi|119026391|ref|YP_910236.1| transposase subunit B 484020000196 putative transposase OrfB; Reviewed; Region: PHA02517 484020000197 putative transposase OrfB; Reviewed; Region: PHA02517 484020000198 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 484020000199 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484020000200 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484020000201 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 484020000202 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 484020000203 Probable Catalytic site; other site 484020000204 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 484020000205 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 484020000206 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 484020000207 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 484020000208 Walker A/P-loop; other site 484020000209 ATP binding site [chemical binding]; other site 484020000210 Q-loop/lid; other site 484020000211 ABC transporter signature motif; other site 484020000212 Walker B; other site 484020000213 D-loop; other site 484020000214 H-loop/switch region; other site 484020000215 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 484020000216 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 484020000217 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484020000218 active site 484020000219 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 484020000220 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484020000221 UDP-galactopyranose mutase; Region: GLF; pfam03275 484020000222 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 484020000223 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 484020000224 NAD binding site [chemical binding]; other site 484020000225 substrate binding site [chemical binding]; other site 484020000226 homodimer interface [polypeptide binding]; other site 484020000227 active site 484020000228 H+ Antiporter protein; Region: 2A0121; TIGR00900 484020000229 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484020000230 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484020000231 putative transporter; Provisional; Region: PRK10504 484020000232 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020000233 putative substrate translocation pore; other site 484020000234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020000235 putative substrate translocation pore; other site 484020000236 FOG: CBS domain [General function prediction only]; Region: COG0517 484020000237 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 484020000238 Integrase core domain; Region: rve_3; pfam13683 484020000239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 484020000240 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 484020000241 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 484020000242 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 484020000243 homodimer interface [polypeptide binding]; other site 484020000244 active site pocket [active] 484020000245 Rhomboid family; Region: Rhomboid; pfam01694 484020000246 HTH-like domain; Region: HTH_21; pfam13276 484020000247 Integrase core domain; Region: rve; pfam00665 484020000248 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 484020000249 putative septation inhibitor protein; Reviewed; Region: PRK02251 484020000250 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 484020000251 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 484020000252 active site 484020000253 catalytic site [active] 484020000254 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 484020000255 Glutamine amidotransferase class-I; Region: GATase; pfam00117 484020000256 glutamine binding [chemical binding]; other site 484020000257 catalytic triad [active] 484020000258 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 484020000259 Catalytic domain of Protein Kinases; Region: PKc; cd00180 484020000260 active site 484020000261 ATP binding site [chemical binding]; other site 484020000262 substrate binding site [chemical binding]; other site 484020000263 activation loop (A-loop); other site 484020000264 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 484020000265 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 484020000266 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 484020000267 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 484020000268 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 484020000269 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 484020000270 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 484020000271 active site 484020000272 ATP binding site [chemical binding]; other site 484020000273 substrate binding site [chemical binding]; other site 484020000274 activation loop (A-loop); other site 484020000275 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 484020000276 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 484020000277 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 484020000278 active site 484020000279 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 484020000280 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 484020000281 phosphopeptide binding site; other site 484020000282 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 484020000283 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 484020000284 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 484020000285 phosphopeptide binding site; other site 484020000286 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 484020000287 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484020000288 Predicted membrane protein [Function unknown]; Region: COG1511 484020000289 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 484020000290 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 484020000291 Predicted membrane protein [Function unknown]; Region: COG1511 484020000292 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 484020000293 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 484020000294 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 484020000295 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 484020000296 EamA-like transporter family; Region: EamA; pfam00892 484020000297 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 484020000298 methionine sulfoxide reductase B; Provisional; Region: PRK00222 484020000299 SelR domain; Region: SelR; pfam01641 484020000300 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 484020000301 PLD-like domain; Region: PLDc_2; pfam13091 484020000302 putative homodimer interface [polypeptide binding]; other site 484020000303 putative active site [active] 484020000304 catalytic site [active] 484020000305 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484020000306 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020000307 ATP binding site [chemical binding]; other site 484020000308 putative Mg++ binding site [ion binding]; other site 484020000309 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020000310 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 484020000311 nucleotide binding region [chemical binding]; other site 484020000312 ATP-binding site [chemical binding]; other site 484020000313 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 484020000314 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 484020000315 active site 484020000316 8-oxo-dGMP binding site [chemical binding]; other site 484020000317 nudix motif; other site 484020000318 metal binding site [ion binding]; metal-binding site 484020000319 DivIVA domain; Region: DivI1A_domain; TIGR03544 484020000320 DivIVA domain; Region: DivI1A_domain; TIGR03544 484020000321 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484020000322 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484020000323 active site 484020000324 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 484020000325 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 484020000326 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484020000327 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 484020000328 Coenzyme A binding pocket [chemical binding]; other site 484020000329 putative transposase OrfB; Reviewed; Region: PHA02517 484020000330 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484020000331 DNA binding site [nucleotide binding] 484020000332 active site 484020000333 Int/Topo IB signature motif; other site 484020000334 HindVP restriction endonuclease; Region: RE_HindVP; pfam09519 484020000335 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 484020000336 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 484020000337 cofactor binding site; other site 484020000338 DNA binding site [nucleotide binding] 484020000339 substrate interaction site [chemical binding]; other site 484020000340 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 484020000341 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 484020000342 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 484020000343 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 484020000344 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 484020000345 protein binding site [polypeptide binding]; other site 484020000346 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 484020000347 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484020000348 Soluble P-type ATPase [General function prediction only]; Region: COG4087 484020000349 ferredoxin-NADP+ reductase; Region: PLN02852 484020000350 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484020000351 heat shock protein HtpX; Provisional; Region: PRK03072 484020000352 Divergent AAA domain; Region: AAA_4; pfam04326 484020000353 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 484020000354 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 484020000355 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 484020000356 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 484020000357 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484020000358 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020000359 non-specific DNA binding site [nucleotide binding]; other site 484020000360 salt bridge; other site 484020000361 sequence-specific DNA binding site [nucleotide binding]; other site 484020000362 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 484020000363 NodB motif; other site 484020000364 active site 484020000365 catalytic site [active] 484020000366 metal binding site [ion binding]; metal-binding site 484020000367 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 484020000368 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 484020000369 active site 484020000370 intersubunit interface [polypeptide binding]; other site 484020000371 zinc binding site [ion binding]; other site 484020000372 Na+ binding site [ion binding]; other site 484020000373 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 484020000374 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 484020000375 GDP-binding site [chemical binding]; other site 484020000376 ACT binding site; other site 484020000377 IMP binding site; other site 484020000378 CrcB-like protein; Region: CRCB; pfam02537 484020000379 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 484020000380 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020000381 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020000382 DNA binding site [nucleotide binding] 484020000383 domain linker motif; other site 484020000384 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 484020000385 dimerization interface [polypeptide binding]; other site 484020000386 ligand binding site [chemical binding]; other site 484020000387 sodium binding site [ion binding]; other site 484020000388 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 484020000389 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484020000390 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020000391 putative substrate translocation pore; other site 484020000392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020000393 metabolite-proton symporter; Region: 2A0106; TIGR00883 484020000394 putative substrate translocation pore; other site 484020000395 ketol-acid reductoisomerase; Provisional; Region: PRK05479 484020000396 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 484020000397 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 484020000398 ketol-acid reductoisomerase; Provisional; Region: PRK05479 484020000399 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 484020000400 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 484020000401 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 484020000402 putative active site [active] 484020000403 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 484020000404 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 484020000405 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 484020000406 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 484020000407 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 484020000408 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484020000409 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484020000410 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 484020000411 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484020000412 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484020000413 Walker A/P-loop; other site 484020000414 ATP binding site [chemical binding]; other site 484020000415 Q-loop/lid; other site 484020000416 ABC transporter signature motif; other site 484020000417 Walker B; other site 484020000418 D-loop; other site 484020000419 H-loop/switch region; other site 484020000420 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484020000421 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 484020000422 FtsX-like permease family; Region: FtsX; pfam02687 484020000423 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 484020000424 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 484020000425 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484020000426 active site 484020000427 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020000428 Q-loop/lid; other site 484020000429 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 484020000430 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 484020000431 catalytic triad [active] 484020000432 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 484020000433 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 484020000434 catalytic residues [active] 484020000435 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 484020000436 Transposase; Region: DDE_Tnp_ISL3; pfam01610 484020000437 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 484020000438 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 484020000439 active site 484020000440 metal binding site [ion binding]; metal-binding site 484020000441 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 484020000442 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 484020000443 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 484020000444 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 484020000445 HNH endonuclease; Region: HNH_2; pfam13391 484020000446 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 484020000447 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 484020000448 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 484020000449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020000450 putative substrate translocation pore; other site 484020000451 Integrase core domain; Region: rve; pfam00665 484020000452 Integrase core domain; Region: rve_2; pfam13333 484020000453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 484020000454 Transposase; Region: HTH_Tnp_1; pfam01527 484020000455 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484020000456 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484020000457 WHG domain; Region: WHG; pfam13305 484020000458 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484020000459 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484020000460 active site 484020000461 catalytic tetrad [active] 484020000462 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 484020000463 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484020000464 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484020000465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020000466 Walker A/P-loop; other site 484020000467 ATP binding site [chemical binding]; other site 484020000468 Q-loop/lid; other site 484020000469 ABC transporter signature motif; other site 484020000470 Walker B; other site 484020000471 D-loop; other site 484020000472 H-loop/switch region; other site 484020000473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484020000474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484020000475 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 484020000476 Walker A/P-loop; other site 484020000477 ATP binding site [chemical binding]; other site 484020000478 Q-loop/lid; other site 484020000479 ABC transporter signature motif; other site 484020000480 Walker B; other site 484020000481 D-loop; other site 484020000482 H-loop/switch region; other site 484020000483 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 484020000484 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 484020000485 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 484020000486 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 484020000487 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 484020000488 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 484020000489 substrate binding site [chemical binding]; other site 484020000490 Peptidase family C69; Region: Peptidase_C69; pfam03577 484020000491 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484020000492 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 484020000493 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 484020000494 Predicted membrane protein [Function unknown]; Region: COG2246 484020000495 GtrA-like protein; Region: GtrA; pfam04138 484020000496 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484020000497 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020000498 putative substrate translocation pore; other site 484020000499 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484020000500 catalytic core [active] 484020000501 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 484020000502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020000503 dimer interface [polypeptide binding]; other site 484020000504 conserved gate region; other site 484020000505 putative PBP binding loops; other site 484020000506 ABC-ATPase subunit interface; other site 484020000507 NMT1/THI5 like; Region: NMT1; pfam09084 484020000508 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 484020000509 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020000510 active site 484020000511 motif I; other site 484020000512 motif II; other site 484020000513 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 484020000514 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 484020000515 HIGH motif; other site 484020000516 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 484020000517 active site 484020000518 KMSKS motif; other site 484020000519 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 484020000520 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 484020000521 putative active site [active] 484020000522 putative metal binding site [ion binding]; other site 484020000523 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 484020000524 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 484020000525 Transcriptional regulator [Transcription]; Region: IclR; COG1414 484020000526 Bacterial transcriptional regulator; Region: IclR; pfam01614 484020000527 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 484020000528 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 484020000529 substrate binding site [chemical binding]; other site 484020000530 ligand binding site [chemical binding]; other site 484020000531 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 484020000532 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 484020000533 substrate binding site [chemical binding]; other site 484020000534 SWIM zinc finger; Region: SWIM; pfam04434 484020000535 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 484020000536 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 484020000537 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020000538 nucleotide binding region [chemical binding]; other site 484020000539 ATP-binding site [chemical binding]; other site 484020000540 CAAX protease self-immunity; Region: Abi; pfam02517 484020000541 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 484020000542 active site 484020000543 FMN binding site [chemical binding]; other site 484020000544 substrate binding site [chemical binding]; other site 484020000545 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 484020000546 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 484020000547 hinge; other site 484020000548 active site 484020000549 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020000550 H+ Antiporter protein; Region: 2A0121; TIGR00900 484020000551 putative substrate translocation pore; other site 484020000552 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484020000553 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484020000554 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 484020000555 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 484020000556 23S rRNA interface [nucleotide binding]; other site 484020000557 L7/L12 interface [polypeptide binding]; other site 484020000558 putative thiostrepton binding site; other site 484020000559 L25 interface [polypeptide binding]; other site 484020000560 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 484020000561 mRNA/rRNA interface [nucleotide binding]; other site 484020000562 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484020000563 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 484020000564 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 484020000565 putative active site; other site 484020000566 putative metal binding residues [ion binding]; other site 484020000567 signature motif; other site 484020000568 putative triphosphate binding site [ion binding]; other site 484020000569 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020000570 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020000571 DNA binding site [nucleotide binding] 484020000572 domain linker motif; other site 484020000573 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 484020000574 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 484020000575 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 484020000576 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 484020000577 substrate binding pocket [chemical binding]; other site 484020000578 classical (c) SDRs; Region: SDR_c; cd05233 484020000579 NAD(P) binding site [chemical binding]; other site 484020000580 active site 484020000581 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 484020000582 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 484020000583 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 484020000584 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 484020000585 homotrimer interaction site [polypeptide binding]; other site 484020000586 putative active site [active] 484020000587 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 484020000588 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 484020000589 active site 484020000590 catalytic site [active] 484020000591 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 484020000592 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 484020000593 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484020000594 active site 484020000595 HIGH motif; other site 484020000596 nucleotide binding site [chemical binding]; other site 484020000597 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 484020000598 KMSK motif region; other site 484020000599 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 484020000600 tRNA binding surface [nucleotide binding]; other site 484020000601 anticodon binding site; other site 484020000602 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 484020000603 catalytic residue [active] 484020000604 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 484020000605 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484020000606 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 484020000607 HPr interaction site; other site 484020000608 glycerol kinase (GK) interaction site [polypeptide binding]; other site 484020000609 active site 484020000610 phosphorylation site [posttranslational modification] 484020000611 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 484020000612 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484020000613 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484020000614 active site turn [active] 484020000615 phosphorylation site [posttranslational modification] 484020000616 homoserine dehydrogenase; Provisional; Region: PRK06349 484020000617 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 484020000618 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 484020000619 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 484020000620 homoserine kinase; Provisional; Region: PRK01212 484020000621 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 484020000622 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 484020000623 putative active site [active] 484020000624 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 484020000625 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 484020000626 nudix motif; other site 484020000627 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484020000628 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 484020000629 Walker A/P-loop; other site 484020000630 ATP binding site [chemical binding]; other site 484020000631 Q-loop/lid; other site 484020000632 ABC transporter signature motif; other site 484020000633 Walker B; other site 484020000634 D-loop; other site 484020000635 H-loop/switch region; other site 484020000636 Predicted permeases [General function prediction only]; Region: COG0679 484020000637 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 484020000638 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 484020000639 metal binding site [ion binding]; metal-binding site 484020000640 putative dimer interface [polypeptide binding]; other site 484020000641 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 484020000642 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 484020000643 homodimer interface [polypeptide binding]; other site 484020000644 oligonucleotide binding site [chemical binding]; other site 484020000645 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 484020000646 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 484020000647 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 484020000648 GTPase CgtA; Reviewed; Region: obgE; PRK12296 484020000649 GTP1/OBG; Region: GTP1_OBG; pfam01018 484020000650 Obg GTPase; Region: Obg; cd01898 484020000651 G1 box; other site 484020000652 GTP/Mg2+ binding site [chemical binding]; other site 484020000653 Switch I region; other site 484020000654 G2 box; other site 484020000655 G3 box; other site 484020000656 Switch II region; other site 484020000657 G4 box; other site 484020000658 G5 box; other site 484020000659 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 484020000660 gamma-glutamyl kinase; Provisional; Region: PRK05429 484020000661 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 484020000662 nucleotide binding site [chemical binding]; other site 484020000663 homotetrameric interface [polypeptide binding]; other site 484020000664 putative phosphate binding site [ion binding]; other site 484020000665 putative allosteric binding site; other site 484020000666 PUA domain; Region: PUA; pfam01472 484020000667 aspartate aminotransferase; Provisional; Region: PRK05764 484020000668 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020000669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020000670 homodimer interface [polypeptide binding]; other site 484020000671 catalytic residue [active] 484020000672 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 484020000673 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 484020000674 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 484020000675 putative homodimer interface [polypeptide binding]; other site 484020000676 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 484020000677 heterodimer interface [polypeptide binding]; other site 484020000678 homodimer interface [polypeptide binding]; other site 484020000679 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484020000680 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 484020000681 putative acyl-acceptor binding pocket; other site 484020000682 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 484020000683 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 484020000684 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 484020000685 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 484020000686 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 484020000687 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484020000688 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 484020000689 active site 484020000690 catalytic site [active] 484020000691 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 484020000692 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 484020000693 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 484020000694 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020000695 sugar binding site [chemical binding]; other site 484020000696 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 484020000697 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 484020000698 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484020000699 active site 484020000700 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 484020000701 Double zinc ribbon; Region: DZR; pfam12773 484020000702 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 484020000703 Double zinc ribbon; Region: DZR; pfam12773 484020000704 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 484020000705 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 484020000706 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 484020000707 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 484020000708 dimer interface [polypeptide binding]; other site 484020000709 ssDNA binding site [nucleotide binding]; other site 484020000710 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484020000711 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 484020000712 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 484020000713 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 484020000714 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 484020000715 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 484020000716 amphipathic channel; other site 484020000717 Asn-Pro-Ala signature motifs; other site 484020000718 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 484020000719 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 484020000720 active site 484020000721 HIGH motif; other site 484020000722 nucleotide binding site [chemical binding]; other site 484020000723 active site 484020000724 KMSKS motif; other site 484020000725 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 484020000726 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484020000727 catalytic residue [active] 484020000728 Acylphosphatase; Region: Acylphosphatase; pfam00708 484020000729 PA14 domain; Region: PA14; cl08459 484020000730 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 484020000731 metal ion-dependent adhesion site (MIDAS); other site 484020000732 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 484020000733 domain interaction interfaces [polypeptide binding]; other site 484020000734 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 484020000735 Cna protein B-type domain; Region: Cna_B; pfam05738 484020000736 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 484020000737 active site 484020000738 catalytic site [active] 484020000739 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 484020000740 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 484020000741 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 484020000742 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 484020000743 Clp amino terminal domain; Region: Clp_N; pfam02861 484020000744 Clp amino terminal domain; Region: Clp_N; pfam02861 484020000745 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020000746 Walker A motif; other site 484020000747 ATP binding site [chemical binding]; other site 484020000748 Walker B motif; other site 484020000749 arginine finger; other site 484020000750 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020000751 Walker A motif; other site 484020000752 ATP binding site [chemical binding]; other site 484020000753 Walker B motif; other site 484020000754 arginine finger; other site 484020000755 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 484020000756 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 484020000757 Mechanosensitive ion channel; Region: MS_channel; pfam00924 484020000758 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484020000759 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484020000760 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 484020000761 aspartate aminotransferase; Provisional; Region: PRK06836 484020000762 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020000763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020000764 homodimer interface [polypeptide binding]; other site 484020000765 catalytic residue [active] 484020000766 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 484020000767 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 484020000768 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 484020000769 acyl-activating enzyme (AAE) consensus motif; other site 484020000770 putative AMP binding site [chemical binding]; other site 484020000771 putative active site [active] 484020000772 putative CoA binding site [chemical binding]; other site 484020000773 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 484020000774 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484020000775 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484020000776 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020000777 non-specific DNA binding site [nucleotide binding]; other site 484020000778 salt bridge; other site 484020000779 sequence-specific DNA binding site [nucleotide binding]; other site 484020000780 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 484020000781 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 484020000782 RelB antitoxin; Region: RelB; cl01171 484020000783 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 484020000784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020000785 DNA methylase; Region: N6_N4_Mtase; pfam01555 484020000786 RelB antitoxin; Region: RelB; cl01171 484020000787 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 484020000788 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 484020000789 DNA binding residues [nucleotide binding] 484020000790 dimer interface [polypeptide binding]; other site 484020000791 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 484020000792 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020000793 putative substrate translocation pore; other site 484020000794 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484020000795 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 484020000796 substrate binding site [chemical binding]; other site 484020000797 ATP binding site [chemical binding]; other site 484020000798 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 484020000799 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 484020000800 ssDNA binding site; other site 484020000801 generic binding surface II; other site 484020000802 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020000803 ATP binding site [chemical binding]; other site 484020000804 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020000805 putative Mg++ binding site [ion binding]; other site 484020000806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020000807 nucleotide binding region [chemical binding]; other site 484020000808 ATP-binding site [chemical binding]; other site 484020000809 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 484020000810 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 484020000811 catalytic residues [active] 484020000812 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 484020000813 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 484020000814 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 484020000815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484020000816 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 484020000817 dimer interface [polypeptide binding]; other site 484020000818 FMN binding site [chemical binding]; other site 484020000819 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 484020000820 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 484020000821 putative dimer interface [polypeptide binding]; other site 484020000822 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 484020000823 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 484020000824 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 484020000825 RimM N-terminal domain; Region: RimM; pfam01782 484020000826 hypothetical protein; Provisional; Region: PRK02821 484020000827 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 484020000828 G-X-X-G motif; other site 484020000829 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 484020000830 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 484020000831 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484020000832 DNA-binding site [nucleotide binding]; DNA binding site 484020000833 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020000834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020000835 homodimer interface [polypeptide binding]; other site 484020000836 catalytic residue [active] 484020000837 LysE type translocator; Region: LysE; cl00565 484020000838 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 484020000839 putative catalytic site [active] 484020000840 putative metal binding site [ion binding]; other site 484020000841 putative phosphate binding site [ion binding]; other site 484020000842 signal recognition particle protein; Provisional; Region: PRK10867 484020000843 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 484020000844 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 484020000845 P loop; other site 484020000846 GTP binding site [chemical binding]; other site 484020000847 Signal peptide binding domain; Region: SRP_SPB; pfam02978 484020000848 Cation efflux family; Region: Cation_efflux; pfam01545 484020000849 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 484020000850 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484020000851 active site 484020000852 HIGH motif; other site 484020000853 nucleotide binding site [chemical binding]; other site 484020000854 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 484020000855 KMSKS motif; other site 484020000856 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 484020000857 tRNA binding surface [nucleotide binding]; other site 484020000858 anticodon binding site; other site 484020000859 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 484020000860 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 484020000861 catalytic triad [active] 484020000862 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484020000863 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484020000864 ABC transporter; Region: ABC_tran_2; pfam12848 484020000865 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484020000866 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484020000867 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 484020000868 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 484020000869 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 484020000870 active site 484020000871 (T/H)XGH motif; other site 484020000872 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 484020000873 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 484020000874 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 484020000875 ribonuclease III; Reviewed; Region: rnc; PRK00102 484020000876 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 484020000877 dimerization interface [polypeptide binding]; other site 484020000878 active site 484020000879 metal binding site [ion binding]; metal-binding site 484020000880 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 484020000881 dsRNA binding site [nucleotide binding]; other site 484020000882 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 484020000883 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 484020000884 PYR/PP interface [polypeptide binding]; other site 484020000885 dimer interface [polypeptide binding]; other site 484020000886 TPP binding site [chemical binding]; other site 484020000887 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 484020000888 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 484020000889 TPP-binding site [chemical binding]; other site 484020000890 dimer interface [polypeptide binding]; other site 484020000891 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 484020000892 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 484020000893 putative valine binding site [chemical binding]; other site 484020000894 dimer interface [polypeptide binding]; other site 484020000895 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 484020000896 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 484020000897 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 484020000898 active site 484020000899 ribonuclease PH; Reviewed; Region: rph; PRK00173 484020000900 Ribonuclease PH; Region: RNase_PH_bact; cd11362 484020000901 hexamer interface [polypeptide binding]; other site 484020000902 active site 484020000903 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 484020000904 active site 484020000905 dimerization interface [polypeptide binding]; other site 484020000906 Membrane transport protein; Region: Mem_trans; cl09117 484020000907 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 484020000908 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 484020000909 active site 484020000910 dimer interface [polypeptide binding]; other site 484020000911 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 484020000912 dimer interface [polypeptide binding]; other site 484020000913 active site 484020000914 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 484020000915 MgtC family; Region: MgtC; pfam02308 484020000916 magnesium-transporting ATPase; Provisional; Region: PRK15122 484020000917 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 484020000918 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484020000919 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 484020000920 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 484020000921 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 484020000922 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 484020000923 Walker A/P-loop; other site 484020000924 ATP binding site [chemical binding]; other site 484020000925 Q-loop/lid; other site 484020000926 ABC transporter signature motif; other site 484020000927 Walker B; other site 484020000928 D-loop; other site 484020000929 H-loop/switch region; other site 484020000930 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 484020000931 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 484020000932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020000933 dimer interface [polypeptide binding]; other site 484020000934 conserved gate region; other site 484020000935 putative PBP binding loops; other site 484020000936 ABC-ATPase subunit interface; other site 484020000937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020000938 dimer interface [polypeptide binding]; other site 484020000939 conserved gate region; other site 484020000940 putative PBP binding loops; other site 484020000941 ABC-ATPase subunit interface; other site 484020000942 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 484020000943 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 484020000944 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 484020000945 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 484020000946 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 484020000947 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 484020000948 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 484020000949 putative N- and C-terminal domain interface [polypeptide binding]; other site 484020000950 putative active site [active] 484020000951 MgATP binding site [chemical binding]; other site 484020000952 catalytic site [active] 484020000953 metal binding site [ion binding]; metal-binding site 484020000954 putative xylulose binding site [chemical binding]; other site 484020000955 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 484020000956 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 484020000957 AP (apurinic/apyrimidinic) site pocket; other site 484020000958 DNA interaction; other site 484020000959 Metal-binding active site; metal-binding site 484020000960 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 484020000961 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 484020000962 intersubunit interface [polypeptide binding]; other site 484020000963 active site 484020000964 Zn2+ binding site [ion binding]; other site 484020000965 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 484020000966 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 484020000967 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 484020000968 Catalytic site [active] 484020000969 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 484020000970 RNA/DNA hybrid binding site [nucleotide binding]; other site 484020000971 active site 484020000972 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020000973 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020000974 DNA binding site [nucleotide binding] 484020000975 domain linker motif; other site 484020000976 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 484020000977 ligand binding site [chemical binding]; other site 484020000978 dimerization interface (open form) [polypeptide binding]; other site 484020000979 dimerization interface (closed form) [polypeptide binding]; other site 484020000980 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 484020000981 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 484020000982 acyl-activating enzyme (AAE) consensus motif; other site 484020000983 putative AMP binding site [chemical binding]; other site 484020000984 putative active site [active] 484020000985 putative CoA binding site [chemical binding]; other site 484020000986 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 484020000987 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 484020000988 active site 484020000989 multimer interface [polypeptide binding]; other site 484020000990 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 484020000991 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 484020000992 predicted active site [active] 484020000993 catalytic triad [active] 484020000994 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 484020000995 active site 484020000996 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020000997 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020000998 DNA binding site [nucleotide binding] 484020000999 domain linker motif; other site 484020001000 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484020001001 ligand binding site [chemical binding]; other site 484020001002 dimerization interface [polypeptide binding]; other site 484020001003 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484020001004 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484020001005 active site 484020001006 catalytic tetrad [active] 484020001007 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 484020001008 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 484020001009 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 484020001010 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 484020001011 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020001012 putative substrate translocation pore; other site 484020001013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020001014 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484020001015 putative substrate translocation pore; other site 484020001016 Domain of unknown function (DUF348); Region: DUF348; pfam03990 484020001017 G5 domain; Region: G5; pfam07501 484020001018 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484020001019 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484020001020 catalytic residue [active] 484020001021 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 484020001022 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 484020001023 catalytic residues [active] 484020001024 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 484020001025 nudix motif; other site 484020001026 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 484020001027 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 484020001028 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 484020001029 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 484020001030 putative NADH binding site [chemical binding]; other site 484020001031 putative active site [active] 484020001032 nudix motif; other site 484020001033 putative metal binding site [ion binding]; other site 484020001034 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 484020001035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 484020001036 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 484020001037 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 484020001038 lipoyl attachment site [posttranslational modification]; other site 484020001039 Uncharacterized conserved protein [Function unknown]; Region: COG4850 484020001040 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 484020001041 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 484020001042 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484020001043 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 484020001044 tartrate dehydrogenase; Region: TTC; TIGR02089 484020001045 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 484020001046 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 484020001047 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 484020001048 ligand binding site [chemical binding]; other site 484020001049 flexible hinge region; other site 484020001050 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 484020001051 putative switch regulator; other site 484020001052 non-specific DNA interactions [nucleotide binding]; other site 484020001053 DNA binding site [nucleotide binding] 484020001054 sequence specific DNA binding site [nucleotide binding]; other site 484020001055 putative cAMP binding site [chemical binding]; other site 484020001056 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 484020001057 Transglycosylase; Region: Transgly; pfam00912 484020001058 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 484020001059 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 484020001060 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 484020001061 active site 484020001062 FMN binding site [chemical binding]; other site 484020001063 substrate binding site [chemical binding]; other site 484020001064 homotetramer interface [polypeptide binding]; other site 484020001065 catalytic residue [active] 484020001066 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 484020001067 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 484020001068 active site 484020001069 catalytic residues [active] 484020001070 FMN binding site [chemical binding]; other site 484020001071 quinone interaction residues [chemical binding]; other site 484020001072 substrate binding site [chemical binding]; other site 484020001073 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 484020001074 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 484020001075 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 484020001076 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 484020001077 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 484020001078 dimer interface [polypeptide binding]; other site 484020001079 active site 484020001080 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 484020001081 galactokinase; Provisional; Region: PRK00555 484020001082 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 484020001083 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 484020001084 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020001085 metabolite-proton symporter; Region: 2A0106; TIGR00883 484020001086 putative substrate translocation pore; other site 484020001087 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 484020001088 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 484020001089 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 484020001090 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 484020001091 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 484020001092 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 484020001093 minor groove reading motif; other site 484020001094 helix-hairpin-helix signature motif; other site 484020001095 active site 484020001096 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 484020001097 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 484020001098 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 484020001099 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 484020001100 RPB1 interaction site [polypeptide binding]; other site 484020001101 RPB10 interaction site [polypeptide binding]; other site 484020001102 RPB11 interaction site [polypeptide binding]; other site 484020001103 RPB3 interaction site [polypeptide binding]; other site 484020001104 RPB12 interaction site [polypeptide binding]; other site 484020001105 RNA polymerase beta' subunit; Region: rpoC1; CHL00018 484020001106 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 484020001107 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 484020001108 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 484020001109 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 484020001110 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 484020001111 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 484020001112 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 484020001113 DNA binding site [nucleotide binding] 484020001114 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 484020001115 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 484020001116 phosphopeptide binding site; other site 484020001117 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 484020001118 active site 484020001119 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 484020001120 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 484020001121 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 484020001122 Protein of unknown function DUF58; Region: DUF58; pfam01882 484020001123 MoxR-like ATPases [General function prediction only]; Region: COG0714 484020001124 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020001125 Walker A motif; other site 484020001126 ATP binding site [chemical binding]; other site 484020001127 Walker B motif; other site 484020001128 arginine finger; other site 484020001129 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 484020001130 Interdomain contacts; other site 484020001131 Cytokine receptor motif; other site 484020001132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 484020001133 Catalytic domain of Protein Kinases; Region: PKc; cd00180 484020001134 active site 484020001135 ATP binding site [chemical binding]; other site 484020001136 substrate binding site [chemical binding]; other site 484020001137 activation loop (A-loop); other site 484020001138 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020001139 Walker A/P-loop; other site 484020001140 ATP binding site [chemical binding]; other site 484020001141 Q-loop/lid; other site 484020001142 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 484020001143 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 484020001144 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 484020001145 Part of AAA domain; Region: AAA_19; pfam13245 484020001146 Family description; Region: UvrD_C_2; pfam13538 484020001147 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 484020001148 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484020001149 Coenzyme A binding pocket [chemical binding]; other site 484020001150 Major Facilitator Superfamily; Region: MFS_1; pfam07690 484020001151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020001152 RelB antitoxin; Region: RelB; cl01171 484020001153 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 484020001154 dihydrodipicolinate reductase; Provisional; Region: PRK00048 484020001155 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 484020001156 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 484020001157 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 484020001158 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 484020001159 dimer interface [polypeptide binding]; other site 484020001160 active site 484020001161 catalytic residue [active] 484020001162 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 484020001163 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 484020001164 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 484020001165 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 484020001166 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 484020001167 Zn binding site [ion binding]; other site 484020001168 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 484020001169 active site 484020001170 catalytic residues [active] 484020001171 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 484020001172 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 484020001173 active site 484020001174 substrate binding site [chemical binding]; other site 484020001175 metal binding site [ion binding]; metal-binding site 484020001176 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 484020001177 active site 484020001178 catalytic residues [active] 484020001179 metal binding site [ion binding]; metal-binding site 484020001180 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 484020001181 additional DNA contacts [nucleotide binding]; other site 484020001182 mismatch recognition site; other site 484020001183 active site 484020001184 zinc binding site [ion binding]; other site 484020001185 DNA intercalation site [nucleotide binding]; other site 484020001186 aminotransferase; Validated; Region: PRK07337 484020001187 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020001188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020001189 homodimer interface [polypeptide binding]; other site 484020001190 catalytic residue [active] 484020001191 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 484020001192 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 484020001193 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 484020001194 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 484020001195 ATP binding site [chemical binding]; other site 484020001196 substrate interface [chemical binding]; other site 484020001197 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 484020001198 active site residue [active] 484020001199 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 484020001200 CPxP motif; other site 484020001201 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 484020001202 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 484020001203 active site 484020001204 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 484020001205 putative catalytic site [active] 484020001206 putative metal binding site [ion binding]; other site 484020001207 putative phosphate binding site [ion binding]; other site 484020001208 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 484020001209 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 484020001210 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 484020001211 generic binding surface II; other site 484020001212 generic binding surface I; other site 484020001213 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 484020001214 ATP cone domain; Region: ATP-cone; pfam03477 484020001215 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 484020001216 Class III ribonucleotide reductase; Region: RNR_III; cd01675 484020001217 active site 484020001218 Zn binding site [ion binding]; other site 484020001219 glycine loop; other site 484020001220 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 484020001221 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 484020001222 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 484020001223 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 484020001224 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 484020001225 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 484020001226 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 484020001227 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 484020001228 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 484020001229 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 484020001230 Right handed beta helix region; Region: Beta_helix; pfam13229 484020001231 Transcriptional regulators [Transcription]; Region: MarR; COG1846 484020001232 MarR family; Region: MarR_2; pfam12802 484020001233 MarR family; Region: MarR_2; cl17246 484020001234 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484020001235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484020001236 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020001237 Walker A/P-loop; other site 484020001238 ATP binding site [chemical binding]; other site 484020001239 Q-loop/lid; other site 484020001240 ABC transporter signature motif; other site 484020001241 Walker B; other site 484020001242 D-loop; other site 484020001243 H-loop/switch region; other site 484020001244 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484020001245 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484020001246 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 484020001247 Walker A/P-loop; other site 484020001248 ATP binding site [chemical binding]; other site 484020001249 Q-loop/lid; other site 484020001250 ABC transporter signature motif; other site 484020001251 Walker B; other site 484020001252 D-loop; other site 484020001253 H-loop/switch region; other site 484020001254 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 484020001255 active site 484020001256 nucleophile elbow; other site 484020001257 glutamate racemase; Provisional; Region: PRK00865 484020001258 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 484020001259 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 484020001260 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 484020001261 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 484020001262 putative active site [active] 484020001263 redox center [active] 484020001264 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 484020001265 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 484020001266 active site 484020001267 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 484020001268 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 484020001269 Phosphotransferase enzyme family; Region: APH; pfam01636 484020001270 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 484020001271 substrate binding site [chemical binding]; other site 484020001272 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 484020001273 Part of AAA domain; Region: AAA_19; pfam13245 484020001274 Family description; Region: UvrD_C_2; pfam13538 484020001275 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 484020001276 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 484020001277 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 484020001278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020001279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020001280 DNA binding site [nucleotide binding] 484020001281 domain linker motif; other site 484020001282 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 484020001283 Domain of unknown function DUF77; Region: DUF77; pfam01910 484020001284 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 484020001285 substrate binding site [chemical binding]; other site 484020001286 dimer interface [polypeptide binding]; other site 484020001287 ATP binding site [chemical binding]; other site 484020001288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020001289 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 484020001290 Walker A motif; other site 484020001291 ATP binding site [chemical binding]; other site 484020001292 Walker B motif; other site 484020001293 arginine finger; other site 484020001294 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 484020001295 thiamine phosphate binding site [chemical binding]; other site 484020001296 active site 484020001297 pyrophosphate binding site [ion binding]; other site 484020001298 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 484020001299 ThiC-associated domain; Region: ThiC-associated; pfam13667 484020001300 ThiC family; Region: ThiC; pfam01964 484020001301 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 484020001302 substrate binding site [chemical binding]; other site 484020001303 multimerization interface [polypeptide binding]; other site 484020001304 ATP binding site [chemical binding]; other site 484020001305 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 484020001306 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 484020001307 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 484020001308 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 484020001309 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 484020001310 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 484020001311 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 484020001312 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020001313 sugar binding site [chemical binding]; other site 484020001314 glycyl-tRNA synthetase; Provisional; Region: PRK04173 484020001315 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484020001316 motif 1; other site 484020001317 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 484020001318 active site 484020001319 motif 2; other site 484020001320 motif 3; other site 484020001321 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 484020001322 anticodon binding site; other site 484020001323 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 484020001324 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 484020001325 FMN binding site [chemical binding]; other site 484020001326 active site 484020001327 catalytic residues [active] 484020001328 substrate binding site [chemical binding]; other site 484020001329 cell division protein FtsZ; Validated; Region: PRK09330 484020001330 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 484020001331 nucleotide binding site [chemical binding]; other site 484020001332 SulA interaction site; other site 484020001333 Protein of unknown function (DUF552); Region: DUF552; pfam04472 484020001334 YGGT family; Region: YGGT; pfam02325 484020001335 DivIVA protein; Region: DivIVA; pfam05103 484020001336 DivIVA domain; Region: DivI1A_domain; TIGR03544 484020001337 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 484020001338 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 484020001339 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 484020001340 active site 484020001341 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 484020001342 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 484020001343 putative trimer interface [polypeptide binding]; other site 484020001344 putative CoA binding site [chemical binding]; other site 484020001345 peptide chain release factor 2; Validated; Region: prfB; PRK00578 484020001346 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 484020001347 This domain is found in peptide chain release factors; Region: PCRF; smart00937 484020001348 RF-1 domain; Region: RF-1; pfam00472 484020001349 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 484020001350 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020001351 Walker A/P-loop; other site 484020001352 ATP binding site [chemical binding]; other site 484020001353 Q-loop/lid; other site 484020001354 ABC transporter signature motif; other site 484020001355 Walker B; other site 484020001356 D-loop; other site 484020001357 H-loop/switch region; other site 484020001358 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 484020001359 CHAP domain; Region: CHAP; pfam05257 484020001360 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 484020001361 SmpB-tmRNA interface; other site 484020001362 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 484020001363 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 484020001364 active site 484020001365 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484020001366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020001367 non-specific DNA binding site [nucleotide binding]; other site 484020001368 salt bridge; other site 484020001369 sequence-specific DNA binding site [nucleotide binding]; other site 484020001370 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 484020001371 DivIVA domain; Region: DivI1A_domain; TIGR03544 484020001372 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 484020001373 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 484020001374 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 484020001375 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 484020001376 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 484020001377 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 484020001378 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 484020001379 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 484020001380 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 484020001381 Recombination protein O N terminal; Region: RecO_N; pfam11967 484020001382 Recombination protein O C terminal; Region: RecO_C; pfam02565 484020001383 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 484020001384 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 484020001385 catalytic residue [active] 484020001386 putative FPP diphosphate binding site; other site 484020001387 putative FPP binding hydrophobic cleft; other site 484020001388 dimer interface [polypeptide binding]; other site 484020001389 putative IPP diphosphate binding site; other site 484020001390 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 484020001391 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 484020001392 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 484020001393 active site 484020001394 PHP Thumb interface [polypeptide binding]; other site 484020001395 metal binding site [ion binding]; metal-binding site 484020001396 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 484020001397 generic binding surface II; other site 484020001398 generic binding surface I; other site 484020001399 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 484020001400 Double zinc ribbon; Region: DZR; pfam12773 484020001401 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 484020001402 myosin-cross-reactive antigen; Provisional; Region: PRK13977 484020001403 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 484020001404 HTH domain; Region: HTH_11; pfam08279 484020001405 Predicted transcriptional regulator [Transcription]; Region: COG2378 484020001406 WYL domain; Region: WYL; pfam13280 484020001407 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484020001408 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484020001409 active site 484020001410 catalytic tetrad [active] 484020001411 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484020001412 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484020001413 active site 484020001414 catalytic tetrad [active] 484020001415 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 484020001416 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 484020001417 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 484020001418 NAD binding site [chemical binding]; other site 484020001419 dimerization interface [polypeptide binding]; other site 484020001420 product binding site; other site 484020001421 substrate binding site [chemical binding]; other site 484020001422 zinc binding site [ion binding]; other site 484020001423 catalytic residues [active] 484020001424 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 484020001425 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020001426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020001427 homodimer interface [polypeptide binding]; other site 484020001428 catalytic residue [active] 484020001429 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 484020001430 putative active site pocket [active] 484020001431 4-fold oligomerization interface [polypeptide binding]; other site 484020001432 metal binding residues [ion binding]; metal-binding site 484020001433 3-fold/trimer interface [polypeptide binding]; other site 484020001434 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 484020001435 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 484020001436 putative active site [active] 484020001437 oxyanion strand; other site 484020001438 catalytic triad [active] 484020001439 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 484020001440 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 484020001441 catalytic residues [active] 484020001442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 484020001443 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 484020001444 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 484020001445 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 484020001446 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 484020001447 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 484020001448 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 484020001449 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020001450 putative Mg++ binding site [ion binding]; other site 484020001451 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020001452 nucleotide binding region [chemical binding]; other site 484020001453 ATP-binding site [chemical binding]; other site 484020001454 Helicase associated domain (HA2); Region: HA2; pfam04408 484020001455 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 484020001456 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 484020001457 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 484020001458 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020001459 S-adenosylmethionine binding site [chemical binding]; other site 484020001460 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 484020001461 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 484020001462 HflX GTPase family; Region: HflX; cd01878 484020001463 G1 box; other site 484020001464 GTP/Mg2+ binding site [chemical binding]; other site 484020001465 Switch I region; other site 484020001466 G2 box; other site 484020001467 G3 box; other site 484020001468 Switch II region; other site 484020001469 G4 box; other site 484020001470 G5 box; other site 484020001471 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 484020001472 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 484020001473 NAD binding site [chemical binding]; other site 484020001474 dimer interface [polypeptide binding]; other site 484020001475 substrate binding site [chemical binding]; other site 484020001476 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484020001477 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 484020001478 LexA repressor; Validated; Region: PRK00215 484020001479 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 484020001480 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 484020001481 Catalytic site [active] 484020001482 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 484020001483 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 484020001484 ATP cone domain; Region: ATP-cone; pfam03477 484020001485 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 484020001486 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 484020001487 ligand binding site [chemical binding]; other site 484020001488 NAD binding site [chemical binding]; other site 484020001489 tetramer interface [polypeptide binding]; other site 484020001490 catalytic site [active] 484020001491 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 484020001492 L-serine binding site [chemical binding]; other site 484020001493 ACT domain interface; other site 484020001494 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 484020001495 Part of AAA domain; Region: AAA_19; pfam13245 484020001496 Family description; Region: UvrD_C_2; pfam13538 484020001497 MraZ protein; Region: MraZ; pfam02381 484020001498 cell division protein MraZ; Reviewed; Region: PRK00326 484020001499 MraZ protein; Region: MraZ; pfam02381 484020001500 MraW methylase family; Region: Methyltransf_5; cl17771 484020001501 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 484020001502 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 484020001503 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 484020001504 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 484020001505 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 484020001506 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 484020001507 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484020001508 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484020001509 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484020001510 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 484020001511 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 484020001512 Mg++ binding site [ion binding]; other site 484020001513 putative catalytic motif [active] 484020001514 putative substrate binding site [chemical binding]; other site 484020001515 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 484020001516 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484020001517 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484020001518 cell division protein FtsW; Region: ftsW; TIGR02614 484020001519 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 484020001520 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 484020001521 active site 484020001522 homodimer interface [polypeptide binding]; other site 484020001523 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 484020001524 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484020001525 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484020001526 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484020001527 cell division protein FtsQ; Provisional; Region: PRK05529 484020001528 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 484020001529 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 484020001530 putative active site [active] 484020001531 dimerization interface [polypeptide binding]; other site 484020001532 putative tRNAtyr binding site [nucleotide binding]; other site 484020001533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020001534 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 484020001535 putative substrate translocation pore; other site 484020001536 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 484020001537 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 484020001538 putative substrate binding site [chemical binding]; other site 484020001539 putative ATP binding site [chemical binding]; other site 484020001540 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484020001541 dimerization interface [polypeptide binding]; other site 484020001542 putative DNA binding site [nucleotide binding]; other site 484020001543 Transcriptional regulators [Transcription]; Region: MarR; COG1846 484020001544 putative Zn2+ binding site [ion binding]; other site 484020001545 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484020001546 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484020001547 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484020001548 CutC family; Region: CutC; cl01218 484020001549 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484020001550 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484020001551 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 484020001552 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 484020001553 active site 484020001554 trimer interface [polypeptide binding]; other site 484020001555 allosteric site; other site 484020001556 active site lid [active] 484020001557 hexamer (dimer of trimers) interface [polypeptide binding]; other site 484020001558 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 484020001559 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 484020001560 active site 484020001561 dimer interface [polypeptide binding]; other site 484020001562 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 484020001563 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 484020001564 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484020001565 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020001566 ABC-ATPase subunit interface; other site 484020001567 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 484020001568 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 484020001569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020001570 dimer interface [polypeptide binding]; other site 484020001571 conserved gate region; other site 484020001572 ABC-ATPase subunit interface; other site 484020001573 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 484020001574 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484020001575 Walker A/P-loop; other site 484020001576 ATP binding site [chemical binding]; other site 484020001577 Q-loop/lid; other site 484020001578 ABC transporter signature motif; other site 484020001579 Walker B; other site 484020001580 D-loop; other site 484020001581 H-loop/switch region; other site 484020001582 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 484020001583 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484020001584 Walker A/P-loop; other site 484020001585 ATP binding site [chemical binding]; other site 484020001586 Q-loop/lid; other site 484020001587 ABC transporter signature motif; other site 484020001588 Walker B; other site 484020001589 D-loop; other site 484020001590 H-loop/switch region; other site 484020001591 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484020001592 proline aminopeptidase P II; Provisional; Region: PRK10879 484020001593 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 484020001594 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 484020001595 active site 484020001596 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 484020001597 nudix motif; other site 484020001598 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 484020001599 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484020001600 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 484020001601 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 484020001602 Walker A/P-loop; other site 484020001603 ATP binding site [chemical binding]; other site 484020001604 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 484020001605 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 484020001606 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 484020001607 ABC transporter signature motif; other site 484020001608 Walker B; other site 484020001609 D-loop; other site 484020001610 H-loop/switch region; other site 484020001611 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 484020001612 aspartate racemase; Region: asp_race; TIGR00035 484020001613 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 484020001614 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 484020001615 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 484020001616 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 484020001617 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 484020001618 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484020001619 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 484020001620 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 484020001621 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484020001622 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 484020001623 DNA binding residues [nucleotide binding] 484020001624 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 484020001625 active site 484020001626 catalytic residues [active] 484020001627 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 484020001628 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 484020001629 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 484020001630 putative deacylase active site [active] 484020001631 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 484020001632 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 484020001633 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 484020001634 Thiamine pyrophosphokinase; Region: TPK; cd07995 484020001635 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 484020001636 active site 484020001637 dimerization interface [polypeptide binding]; other site 484020001638 thiamine binding site [chemical binding]; other site 484020001639 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 484020001640 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 484020001641 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 484020001642 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 484020001643 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 484020001644 23S rRNA binding site [nucleotide binding]; other site 484020001645 L21 binding site [polypeptide binding]; other site 484020001646 L13 binding site [polypeptide binding]; other site 484020001647 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 484020001648 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 484020001649 active site 484020001650 Int/Topo IB signature motif; other site 484020001651 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 484020001652 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484020001653 P-loop; other site 484020001654 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484020001655 Magnesium ion binding site [ion binding]; other site 484020001656 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484020001657 Magnesium ion binding site [ion binding]; other site 484020001658 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 484020001659 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 484020001660 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 484020001661 nudix motif; other site 484020001662 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 484020001663 quinolinate synthetase; Provisional; Region: PRK09375 484020001664 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 484020001665 L-aspartate oxidase; Provisional; Region: PRK06175 484020001666 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 484020001667 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 484020001668 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 484020001669 dimerization interface [polypeptide binding]; other site 484020001670 active site 484020001671 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 484020001672 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 484020001673 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484020001674 catalytic residue [active] 484020001675 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 484020001676 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 484020001677 G1 box; other site 484020001678 putative GEF interaction site [polypeptide binding]; other site 484020001679 GTP/Mg2+ binding site [chemical binding]; other site 484020001680 Switch I region; other site 484020001681 G2 box; other site 484020001682 G3 box; other site 484020001683 Switch II region; other site 484020001684 G4 box; other site 484020001685 G5 box; other site 484020001686 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 484020001687 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 484020001688 Prephenate dehydratase; Region: PDT; pfam00800 484020001689 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 484020001690 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 484020001691 putative L-Phe binding site [chemical binding]; other site 484020001692 prephenate dehydrogenase; Validated; Region: PRK08507 484020001693 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 484020001694 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484020001695 active site 484020001696 DNA binding site [nucleotide binding] 484020001697 Int/Topo IB signature motif; other site 484020001698 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484020001699 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020001700 dimer interface [polypeptide binding]; other site 484020001701 conserved gate region; other site 484020001702 putative PBP binding loops; other site 484020001703 ABC-ATPase subunit interface; other site 484020001704 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 484020001705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020001706 dimer interface [polypeptide binding]; other site 484020001707 conserved gate region; other site 484020001708 putative PBP binding loops; other site 484020001709 ABC-ATPase subunit interface; other site 484020001710 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 484020001711 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484020001712 Walker A/P-loop; other site 484020001713 ATP binding site [chemical binding]; other site 484020001714 Q-loop/lid; other site 484020001715 ABC transporter signature motif; other site 484020001716 Walker B; other site 484020001717 D-loop; other site 484020001718 H-loop/switch region; other site 484020001719 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484020001720 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484020001721 Walker A/P-loop; other site 484020001722 ATP binding site [chemical binding]; other site 484020001723 Q-loop/lid; other site 484020001724 ABC transporter signature motif; other site 484020001725 Walker B; other site 484020001726 D-loop; other site 484020001727 H-loop/switch region; other site 484020001728 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 484020001729 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 484020001730 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 484020001731 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 484020001732 trimer interface [polypeptide binding]; other site 484020001733 active site 484020001734 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 484020001735 putative active site [active] 484020001736 putative catalytic site [active] 484020001737 putative DNA binding site [nucleotide binding]; other site 484020001738 putative phosphate binding site [ion binding]; other site 484020001739 metal binding site A [ion binding]; metal-binding site 484020001740 putative AP binding site [nucleotide binding]; other site 484020001741 putative metal binding site B [ion binding]; other site 484020001742 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 484020001743 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 484020001744 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 484020001745 TRAM domain; Region: TRAM; cl01282 484020001746 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020001747 S-adenosylmethionine binding site [chemical binding]; other site 484020001748 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 484020001749 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 484020001750 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 484020001751 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484020001752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 484020001753 motif II; other site 484020001754 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 484020001755 aconitate hydratase; Validated; Region: PRK09277 484020001756 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 484020001757 substrate binding site [chemical binding]; other site 484020001758 ligand binding site [chemical binding]; other site 484020001759 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 484020001760 substrate binding site [chemical binding]; other site 484020001761 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 484020001762 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 484020001763 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 484020001764 S-adenosylmethionine synthetase; Validated; Region: PRK05250 484020001765 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 484020001766 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 484020001767 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 484020001768 primosome assembly protein PriA; Provisional; Region: PRK14873 484020001769 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 484020001770 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020001771 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 484020001772 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 484020001773 putative active site [active] 484020001774 substrate binding site [chemical binding]; other site 484020001775 putative cosubstrate binding site; other site 484020001776 catalytic site [active] 484020001777 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 484020001778 substrate binding site [chemical binding]; other site 484020001779 phosphoserine phosphatase SerB; Region: serB; TIGR00338 484020001780 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020001781 motif II; other site 484020001782 proteasome ATPase; Region: pup_AAA; TIGR03689 484020001783 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020001784 Walker A motif; other site 484020001785 ATP binding site [chemical binding]; other site 484020001786 Walker B motif; other site 484020001787 arginine finger; other site 484020001788 Pup-ligase protein; Region: Pup_ligase; cl15463 484020001789 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 484020001790 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 484020001791 active site 484020001792 Pup-like protein; Region: Pup; cl05289 484020001793 Pup-ligase protein; Region: Pup_ligase; cl15463 484020001794 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 484020001795 IHF dimer interface [polypeptide binding]; other site 484020001796 IHF - DNA interface [nucleotide binding]; other site 484020001797 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 484020001798 adenylosuccinate lyase; Provisional; Region: PRK09285 484020001799 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 484020001800 tetramer interface [polypeptide binding]; other site 484020001801 active site 484020001802 Secretory lipase; Region: LIP; pfam03583 484020001803 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 484020001804 metal ion-dependent adhesion site (MIDAS); other site 484020001805 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 484020001806 metal ion-dependent adhesion site (MIDAS); other site 484020001807 Protein of unknown function DUF58; Region: DUF58; pfam01882 484020001808 MoxR-like ATPases [General function prediction only]; Region: COG0714 484020001809 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 484020001810 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 484020001811 ligand binding site [chemical binding]; other site 484020001812 active site 484020001813 UGI interface [polypeptide binding]; other site 484020001814 catalytic site [active] 484020001815 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 484020001816 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 484020001817 DNA-binding site [nucleotide binding]; DNA binding site 484020001818 RNA-binding motif; other site 484020001819 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 484020001820 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 484020001821 ring oligomerisation interface [polypeptide binding]; other site 484020001822 ATP/Mg binding site [chemical binding]; other site 484020001823 stacking interactions; other site 484020001824 hinge regions; other site 484020001825 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 484020001826 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484020001827 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020001828 active site 484020001829 phosphorylation site [posttranslational modification] 484020001830 intermolecular recognition site; other site 484020001831 dimerization interface [polypeptide binding]; other site 484020001832 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484020001833 DNA binding site [nucleotide binding] 484020001834 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484020001835 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484020001836 dimerization interface [polypeptide binding]; other site 484020001837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484020001838 dimer interface [polypeptide binding]; other site 484020001839 phosphorylation site [posttranslational modification] 484020001840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020001841 ATP binding site [chemical binding]; other site 484020001842 Mg2+ binding site [ion binding]; other site 484020001843 G-X-G motif; other site 484020001844 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 484020001845 DNA-binding site [nucleotide binding]; DNA binding site 484020001846 RNA-binding motif; other site 484020001847 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 484020001848 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484020001849 Ligand Binding Site [chemical binding]; other site 484020001850 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484020001851 Ligand Binding Site [chemical binding]; other site 484020001852 Clp protease ATP binding subunit; Region: clpC; CHL00095 484020001853 Clp amino terminal domain; Region: Clp_N; pfam02861 484020001854 Clp amino terminal domain; Region: Clp_N; pfam02861 484020001855 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020001856 Walker A motif; other site 484020001857 ATP binding site [chemical binding]; other site 484020001858 Walker B motif; other site 484020001859 arginine finger; other site 484020001860 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020001861 Walker A motif; other site 484020001862 ATP binding site [chemical binding]; other site 484020001863 Walker B motif; other site 484020001864 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 484020001865 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 484020001866 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 484020001867 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 484020001868 dimer interface [polypeptide binding]; other site 484020001869 motif 1; other site 484020001870 active site 484020001871 motif 2; other site 484020001872 motif 3; other site 484020001873 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 484020001874 anticodon binding site; other site 484020001875 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 484020001876 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 484020001877 dimer interface [polypeptide binding]; other site 484020001878 anticodon binding site; other site 484020001879 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484020001880 motif 1; other site 484020001881 dimer interface [polypeptide binding]; other site 484020001882 active site 484020001883 motif 2; other site 484020001884 GAD domain; Region: GAD; pfam02938 484020001885 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484020001886 active site 484020001887 motif 3; other site 484020001888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020001889 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484020001890 active site 484020001891 phosphorylation site [posttranslational modification] 484020001892 intermolecular recognition site; other site 484020001893 dimerization interface [polypeptide binding]; other site 484020001894 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484020001895 DNA binding residues [nucleotide binding] 484020001896 dimerization interface [polypeptide binding]; other site 484020001897 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 484020001898 putative deacylase active site [active] 484020001899 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 484020001900 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 484020001901 Walker A/P-loop; other site 484020001902 ATP binding site [chemical binding]; other site 484020001903 Q-loop/lid; other site 484020001904 ABC transporter signature motif; other site 484020001905 Walker B; other site 484020001906 D-loop; other site 484020001907 H-loop/switch region; other site 484020001908 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484020001909 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 484020001910 substrate binding pocket [chemical binding]; other site 484020001911 membrane-bound complex binding site; other site 484020001912 hinge residues; other site 484020001913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020001914 dimer interface [polypeptide binding]; other site 484020001915 conserved gate region; other site 484020001916 ABC-ATPase subunit interface; other site 484020001917 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 484020001918 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020001919 dimer interface [polypeptide binding]; other site 484020001920 conserved gate region; other site 484020001921 putative PBP binding loops; other site 484020001922 ABC-ATPase subunit interface; other site 484020001923 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 484020001924 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020001925 ATP binding site [chemical binding]; other site 484020001926 putative Mg++ binding site [ion binding]; other site 484020001927 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020001928 nucleotide binding region [chemical binding]; other site 484020001929 ATP-binding site [chemical binding]; other site 484020001930 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 484020001931 recombination factor protein RarA; Reviewed; Region: PRK13342 484020001932 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020001933 Walker A motif; other site 484020001934 ATP binding site [chemical binding]; other site 484020001935 Walker B motif; other site 484020001936 arginine finger; other site 484020001937 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 484020001938 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020001939 putative substrate translocation pore; other site 484020001940 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020001941 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 484020001942 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 484020001943 Walker A/P-loop; other site 484020001944 ATP binding site [chemical binding]; other site 484020001945 Q-loop/lid; other site 484020001946 ABC transporter signature motif; other site 484020001947 Walker B; other site 484020001948 D-loop; other site 484020001949 H-loop/switch region; other site 484020001950 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 484020001951 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 484020001952 Walker A/P-loop; other site 484020001953 ATP binding site [chemical binding]; other site 484020001954 Q-loop/lid; other site 484020001955 ABC transporter signature motif; other site 484020001956 Walker B; other site 484020001957 D-loop; other site 484020001958 H-loop/switch region; other site 484020001959 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 484020001960 Predicted membrane protein [Function unknown]; Region: COG3601 484020001961 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484020001962 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484020001963 nucleotide binding site [chemical binding]; other site 484020001964 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020001965 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020001966 homodimer interface [polypeptide binding]; other site 484020001967 catalytic residue [active] 484020001968 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020001969 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 484020001970 Walker A/P-loop; other site 484020001971 ATP binding site [chemical binding]; other site 484020001972 Q-loop/lid; other site 484020001973 ABC transporter signature motif; other site 484020001974 Walker B; other site 484020001975 D-loop; other site 484020001976 H-loop/switch region; other site 484020001977 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 484020001978 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484020001979 binding surface 484020001980 TPR motif; other site 484020001981 Ligase N family; Region: LIGANc; smart00532 484020001982 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 484020001983 nucleotide binding pocket [chemical binding]; other site 484020001984 K-X-D-G motif; other site 484020001985 catalytic site [active] 484020001986 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 484020001987 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 484020001988 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 484020001989 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 484020001990 Dimer interface [polypeptide binding]; other site 484020001991 Domain of unknown function DUF59; Region: DUF59; cl00941 484020001992 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 484020001993 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 484020001994 Walker A motif; other site 484020001995 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 484020001996 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484020001997 active site 484020001998 DNA binding site [nucleotide binding] 484020001999 Int/Topo IB signature motif; other site 484020002000 Methyltransferase domain; Region: Methyltransf_26; pfam13659 484020002001 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 484020002002 GIY-YIG motif/motif A; other site 484020002003 putative active site [active] 484020002004 putative metal binding site [ion binding]; other site 484020002005 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 484020002006 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 484020002007 Helix-turn-helix domain; Region: HTH_17; pfam12728 484020002008 glutamine synthetase, type I; Region: GlnA; TIGR00653 484020002009 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 484020002010 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 484020002011 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 484020002012 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 484020002013 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 484020002014 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484020002015 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484020002016 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 484020002017 hypothetical protein; Provisional; Region: PRK07907 484020002018 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 484020002019 active site 484020002020 metal binding site [ion binding]; metal-binding site 484020002021 dimer interface [polypeptide binding]; other site 484020002022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020002023 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 484020002024 Walker A/P-loop; other site 484020002025 ATP binding site [chemical binding]; other site 484020002026 Q-loop/lid; other site 484020002027 ABC transporter signature motif; other site 484020002028 Walker B; other site 484020002029 D-loop; other site 484020002030 H-loop/switch region; other site 484020002031 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 484020002032 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 484020002033 Uncharacterized conserved protein [Function unknown]; Region: COG1615 484020002034 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 484020002035 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 484020002036 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 484020002037 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 484020002038 Acyltransferase family; Region: Acyl_transf_3; pfam01757 484020002039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 484020002040 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 484020002041 substrate binding site; other site 484020002042 dimer interface; other site 484020002043 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 484020002044 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484020002045 NAD(P) binding site [chemical binding]; other site 484020002046 active site 484020002047 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 484020002048 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 484020002049 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 484020002050 Walker A/P-loop; other site 484020002051 ATP binding site [chemical binding]; other site 484020002052 Q-loop/lid; other site 484020002053 ABC transporter signature motif; other site 484020002054 Walker B; other site 484020002055 D-loop; other site 484020002056 H-loop/switch region; other site 484020002057 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 484020002058 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484020002059 Coenzyme A binding pocket [chemical binding]; other site 484020002060 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 484020002061 putative active site [active] 484020002062 catalytic residue [active] 484020002063 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 484020002064 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 484020002065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020002066 ATP binding site [chemical binding]; other site 484020002067 putative Mg++ binding site [ion binding]; other site 484020002068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020002069 nucleotide binding region [chemical binding]; other site 484020002070 ATP-binding site [chemical binding]; other site 484020002071 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 484020002072 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 484020002073 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 484020002074 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 484020002075 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 484020002076 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 484020002077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020002078 catalytic residue [active] 484020002079 enolase; Provisional; Region: eno; PRK00077 484020002080 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 484020002081 dimer interface [polypeptide binding]; other site 484020002082 metal binding site [ion binding]; metal-binding site 484020002083 substrate binding pocket [chemical binding]; other site 484020002084 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 484020002085 Septum formation initiator; Region: DivIC; pfam04977 484020002086 Protein of unknown function (DUF501); Region: DUF501; pfam04417 484020002087 putative hydrolase; Provisional; Region: PRK11460 484020002088 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 484020002089 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 484020002090 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 484020002091 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 484020002092 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 484020002093 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484020002094 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 484020002095 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 484020002096 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 484020002097 V-type ATP synthase subunit E; Provisional; Region: PRK01558 484020002098 Haemolysin-III related; Region: HlyIII; pfam03006 484020002099 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 484020002100 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 484020002101 PAS fold; Region: PAS_4; pfam08448 484020002102 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 484020002103 Histidine kinase; Region: HisKA_2; pfam07568 484020002104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020002105 ATP binding site [chemical binding]; other site 484020002106 Mg2+ binding site [ion binding]; other site 484020002107 G-X-G motif; other site 484020002108 Transcription factor WhiB; Region: Whib; pfam02467 484020002109 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 484020002110 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 484020002111 Transcription factor WhiB; Region: Whib; pfam02467 484020002112 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484020002113 active site 484020002114 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 484020002115 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484020002116 Predicted integral membrane protein [Function unknown]; Region: COG5617 484020002117 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 484020002118 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 484020002119 Eukaryotic phosphomannomutase; Region: PMM; cl17107 484020002120 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 484020002121 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484020002122 active site 484020002123 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 484020002124 Catalytic site [active] 484020002125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484020002126 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 484020002127 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484020002128 dimerization interface [polypeptide binding]; other site 484020002129 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484020002130 dimer interface [polypeptide binding]; other site 484020002131 phosphorylation site [posttranslational modification] 484020002132 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020002133 ATP binding site [chemical binding]; other site 484020002134 Mg2+ binding site [ion binding]; other site 484020002135 G-X-G motif; other site 484020002136 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484020002137 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020002138 active site 484020002139 phosphorylation site [posttranslational modification] 484020002140 intermolecular recognition site; other site 484020002141 dimerization interface [polypeptide binding]; other site 484020002142 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484020002143 DNA binding site [nucleotide binding] 484020002144 glycogen branching enzyme; Provisional; Region: PRK05402 484020002145 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 484020002146 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 484020002147 active site 484020002148 catalytic site [active] 484020002149 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 484020002150 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 484020002151 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 484020002152 homotrimer interaction site [polypeptide binding]; other site 484020002153 zinc binding site [ion binding]; other site 484020002154 CDP-binding sites; other site 484020002155 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 484020002156 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 484020002157 ABC-ATPase subunit interface; other site 484020002158 dimer interface [polypeptide binding]; other site 484020002159 putative PBP binding regions; other site 484020002160 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 484020002161 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 484020002162 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 484020002163 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 484020002164 metal binding site [ion binding]; metal-binding site 484020002165 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 484020002166 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 484020002167 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 484020002168 homodimer interface [polypeptide binding]; other site 484020002169 NADP binding site [chemical binding]; other site 484020002170 substrate binding site [chemical binding]; other site 484020002171 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 484020002172 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 484020002173 RNA binding site [nucleotide binding]; other site 484020002174 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 484020002175 RNA binding site [nucleotide binding]; other site 484020002176 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 484020002177 RNA binding site [nucleotide binding]; other site 484020002178 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 484020002179 RNA binding site [nucleotide binding]; other site 484020002180 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 484020002181 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 484020002182 CoA-binding site [chemical binding]; other site 484020002183 ATP-binding [chemical binding]; other site 484020002184 excinuclease ABC subunit B; Provisional; Region: PRK05298 484020002185 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020002186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020002187 nucleotide binding region [chemical binding]; other site 484020002188 ATP-binding site [chemical binding]; other site 484020002189 Ultra-violet resistance protein B; Region: UvrB; pfam12344 484020002190 UvrB/uvrC motif; Region: UVR; pfam02151 484020002191 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 484020002192 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 484020002193 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 484020002194 domain interfaces; other site 484020002195 active site 484020002196 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 484020002197 dimer interface [polypeptide binding]; other site 484020002198 ADP-ribose binding site [chemical binding]; other site 484020002199 active site 484020002200 nudix motif; other site 484020002201 metal binding site [ion binding]; metal-binding site 484020002202 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 484020002203 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020002204 active site 484020002205 phosphorylation site [posttranslational modification] 484020002206 intermolecular recognition site; other site 484020002207 dimerization interface [polypeptide binding]; other site 484020002208 ANTAR domain; Region: ANTAR; pfam03861 484020002209 DNA polymerase I; Provisional; Region: PRK05755 484020002210 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 484020002211 active site 484020002212 metal binding site 1 [ion binding]; metal-binding site 484020002213 putative 5' ssDNA interaction site; other site 484020002214 metal binding site 3; metal-binding site 484020002215 metal binding site 2 [ion binding]; metal-binding site 484020002216 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 484020002217 putative DNA binding site [nucleotide binding]; other site 484020002218 putative metal binding site [ion binding]; other site 484020002219 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 484020002220 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 484020002221 active site 484020002222 DNA binding site [nucleotide binding] 484020002223 catalytic site [active] 484020002224 Uncharacterized conserved protein [Function unknown]; Region: COG0327 484020002225 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 484020002226 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 484020002227 dimer interface [polypeptide binding]; other site 484020002228 ADP-ribose binding site [chemical binding]; other site 484020002229 active site 484020002230 nudix motif; other site 484020002231 metal binding site [ion binding]; metal-binding site 484020002232 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 484020002233 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 484020002234 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 484020002235 active site 484020002236 catalytic site [active] 484020002237 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 484020002238 Int/Topo IB signature motif; other site 484020002239 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 484020002240 conserved cys residue [active] 484020002241 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 484020002242 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 484020002243 hinge; other site 484020002244 active site 484020002245 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 484020002246 propionate/acetate kinase; Provisional; Region: PRK12379 484020002247 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 484020002248 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 484020002249 hypothetical protein; Provisional; Region: PRK13663 484020002250 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 484020002251 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 484020002252 Helix-turn-helix domain; Region: HTH_17; cl17695 484020002253 Aminoglycoside-2''-adenylyltransferase; Region: Aminoglyc_resit; pfam10706 484020002254 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 484020002255 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484020002256 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484020002257 Plasmid recombination enzyme; Region: Mob_Pre; pfam01076 484020002258 AAA domain; Region: AAA_25; pfam13481 484020002259 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 484020002260 Walker A motif; other site 484020002261 ATP binding site [chemical binding]; other site 484020002262 Walker B motif; other site 484020002263 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484020002264 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484020002265 GMP synthase; Reviewed; Region: guaA; PRK00074 484020002266 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 484020002267 AMP/PPi binding site [chemical binding]; other site 484020002268 candidate oxyanion hole; other site 484020002269 catalytic triad [active] 484020002270 potential glutamine specificity residues [chemical binding]; other site 484020002271 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 484020002272 ATP Binding subdomain [chemical binding]; other site 484020002273 Ligand Binding sites [chemical binding]; other site 484020002274 Dimerization subdomain; other site 484020002275 putative phosphoketolase; Provisional; Region: PRK05261 484020002276 XFP N-terminal domain; Region: XFP_N; pfam09364 484020002277 XFP C-terminal domain; Region: XFP_C; pfam09363 484020002278 Phosphate transporter family; Region: PHO4; pfam01384 484020002279 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 484020002280 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484020002281 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020002282 active site 484020002283 phosphorylation site [posttranslational modification] 484020002284 intermolecular recognition site; other site 484020002285 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484020002286 DNA binding residues [nucleotide binding] 484020002287 dimerization interface [polypeptide binding]; other site 484020002288 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 484020002289 Histidine kinase; Region: HisKA_3; pfam07730 484020002290 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 484020002291 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484020002292 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484020002293 Walker A/P-loop; other site 484020002294 ATP binding site [chemical binding]; other site 484020002295 Q-loop/lid; other site 484020002296 ABC transporter signature motif; other site 484020002297 Walker B; other site 484020002298 D-loop; other site 484020002299 H-loop/switch region; other site 484020002300 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 484020002301 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 484020002302 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 484020002303 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 484020002304 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 484020002305 Divergent AAA domain; Region: AAA_4; pfam04326 484020002306 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 484020002307 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484020002308 Integrase core domain; Region: rve; pfam00665 484020002309 MobA/MobL family; Region: MobA_MobL; pfam03389 484020002310 Transposase; Region: HTH_Tnp_1; pfam01527 484020002311 putative transposase OrfB; Reviewed; Region: PHA02517 484020002312 Integrase core domain; Region: rve; pfam00665 484020002313 Integrase core domain; Region: rve_3; pfam13683 484020002314 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 484020002315 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 484020002316 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 484020002317 Isochorismatase family; Region: Isochorismatase; pfam00857 484020002318 catalytic triad [active] 484020002319 metal binding site [ion binding]; metal-binding site 484020002320 conserved cis-peptide bond; other site 484020002321 xanthine permease; Region: pbuX; TIGR03173 484020002322 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484020002323 active site 484020002324 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 484020002325 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 484020002326 active site 484020002327 catalytic triad [active] 484020002328 oxyanion hole [active] 484020002329 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 484020002330 Part of AAA domain; Region: AAA_19; pfam13245 484020002331 Family description; Region: UvrD_C_2; pfam13538 484020002332 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 484020002333 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484020002334 FtsX-like permease family; Region: FtsX; pfam02687 484020002335 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484020002336 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484020002337 Walker A/P-loop; other site 484020002338 ATP binding site [chemical binding]; other site 484020002339 Q-loop/lid; other site 484020002340 ABC transporter signature motif; other site 484020002341 Walker B; other site 484020002342 D-loop; other site 484020002343 H-loop/switch region; other site 484020002344 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 484020002345 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 484020002346 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484020002347 RNA binding surface [nucleotide binding]; other site 484020002348 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 484020002349 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 484020002350 catalytic triad [active] 484020002351 catalytic triad [active] 484020002352 oxyanion hole [active] 484020002353 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484020002354 catalytic core [active] 484020002355 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 484020002356 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 484020002357 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 484020002358 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 484020002359 motif 1; other site 484020002360 active site 484020002361 motif 2; other site 484020002362 motif 3; other site 484020002363 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 484020002364 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 484020002365 YceG-like family; Region: YceG; pfam02618 484020002366 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 484020002367 dimerization interface [polypeptide binding]; other site 484020002368 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 484020002369 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 484020002370 Tetramer interface [polypeptide binding]; other site 484020002371 active site 484020002372 FMN-binding site [chemical binding]; other site 484020002373 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 484020002374 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 484020002375 ADP binding site [chemical binding]; other site 484020002376 magnesium binding site [ion binding]; other site 484020002377 putative shikimate binding site; other site 484020002378 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 484020002379 active site 484020002380 dimer interface [polypeptide binding]; other site 484020002381 metal binding site [ion binding]; metal-binding site 484020002382 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 484020002383 Dehydroquinase class II; Region: DHquinase_II; pfam01220 484020002384 trimer interface [polypeptide binding]; other site 484020002385 active site 484020002386 dimer interface [polypeptide binding]; other site 484020002387 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484020002388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020002389 active site 484020002390 phosphorylation site [posttranslational modification] 484020002391 intermolecular recognition site; other site 484020002392 dimerization interface [polypeptide binding]; other site 484020002393 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484020002394 DNA binding residues [nucleotide binding] 484020002395 dimerization interface [polypeptide binding]; other site 484020002396 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 484020002397 CTP synthetase; Validated; Region: pyrG; PRK05380 484020002398 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 484020002399 Catalytic site [active] 484020002400 active site 484020002401 UTP binding site [chemical binding]; other site 484020002402 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 484020002403 active site 484020002404 putative oxyanion hole; other site 484020002405 catalytic triad [active] 484020002406 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 484020002407 FeS assembly protein SufB; Region: sufB; TIGR01980 484020002408 FeS assembly protein SufD; Region: sufD; TIGR01981 484020002409 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 484020002410 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 484020002411 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 484020002412 Walker A/P-loop; other site 484020002413 ATP binding site [chemical binding]; other site 484020002414 Q-loop/lid; other site 484020002415 ABC transporter signature motif; other site 484020002416 Walker B; other site 484020002417 D-loop; other site 484020002418 H-loop/switch region; other site 484020002419 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 484020002420 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 484020002421 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484020002422 catalytic residue [active] 484020002423 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 484020002424 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 484020002425 trimerization site [polypeptide binding]; other site 484020002426 active site 484020002427 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 484020002428 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 484020002429 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 484020002430 ligand binding site; other site 484020002431 oligomer interface; other site 484020002432 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 484020002433 dimer interface [polypeptide binding]; other site 484020002434 N-terminal domain interface [polypeptide binding]; other site 484020002435 sulfate 1 binding site; other site 484020002436 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 484020002437 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 484020002438 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 484020002439 RNA methyltransferase, RsmE family; Region: TIGR00046 484020002440 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 484020002441 nucleotide binding site/active site [active] 484020002442 HIT family signature motif; other site 484020002443 catalytic residue [active] 484020002444 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 484020002445 PhoH-like protein; Region: PhoH; pfam02562 484020002446 metal-binding heat shock protein; Provisional; Region: PRK00016 484020002447 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 484020002448 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 484020002449 Transporter associated domain; Region: CorC_HlyC; smart01091 484020002450 GTPase Era; Reviewed; Region: era; PRK00089 484020002451 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 484020002452 G1 box; other site 484020002453 GTP/Mg2+ binding site [chemical binding]; other site 484020002454 Switch I region; other site 484020002455 G2 box; other site 484020002456 Switch II region; other site 484020002457 G3 box; other site 484020002458 G4 box; other site 484020002459 G5 box; other site 484020002460 KH domain; Region: KH_2; pfam07650 484020002461 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 484020002462 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 484020002463 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 484020002464 acyl-activating enzyme (AAE) consensus motif; other site 484020002465 putative AMP binding site [chemical binding]; other site 484020002466 putative active site [active] 484020002467 putative CoA binding site [chemical binding]; other site 484020002468 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 484020002469 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 484020002470 ligand binding site [chemical binding]; other site 484020002471 homodimer interface [polypeptide binding]; other site 484020002472 NAD(P) binding site [chemical binding]; other site 484020002473 trimer interface B [polypeptide binding]; other site 484020002474 trimer interface A [polypeptide binding]; other site 484020002475 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 484020002476 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 484020002477 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 484020002478 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 484020002479 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 484020002480 5S rRNA interface [nucleotide binding]; other site 484020002481 CTC domain interface [polypeptide binding]; other site 484020002482 L16 interface [polypeptide binding]; other site 484020002483 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 484020002484 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 484020002485 homodimer interface [polypeptide binding]; other site 484020002486 substrate-cofactor binding pocket; other site 484020002487 catalytic residue [active] 484020002488 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 484020002489 active site 484020002490 metal binding site [ion binding]; metal-binding site 484020002491 UPF0126 domain; Region: UPF0126; pfam03458 484020002492 Predicted membrane protein [Function unknown]; Region: COG2860 484020002493 UPF0126 domain; Region: UPF0126; pfam03458 484020002494 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 484020002495 GTP-binding protein LepA; Provisional; Region: PRK05433 484020002496 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 484020002497 G1 box; other site 484020002498 putative GEF interaction site [polypeptide binding]; other site 484020002499 GTP/Mg2+ binding site [chemical binding]; other site 484020002500 Switch I region; other site 484020002501 G2 box; other site 484020002502 G3 box; other site 484020002503 Switch II region; other site 484020002504 G4 box; other site 484020002505 G5 box; other site 484020002506 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 484020002507 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 484020002508 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 484020002509 coproporphyrinogen III oxidase; Validated; Region: PRK05628 484020002510 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484020002511 FeS/SAM binding site; other site 484020002512 HemN C-terminal domain; Region: HemN_C; pfam06969 484020002513 Predicted membrane protein [Function unknown]; Region: COG2364 484020002514 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 484020002515 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020002516 salt bridge; other site 484020002517 non-specific DNA binding site [nucleotide binding]; other site 484020002518 sequence-specific DNA binding site [nucleotide binding]; other site 484020002519 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020002520 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020002521 homodimer interface [polypeptide binding]; other site 484020002522 catalytic residue [active] 484020002523 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 484020002524 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 484020002525 G1 box; other site 484020002526 putative GEF interaction site [polypeptide binding]; other site 484020002527 GTP/Mg2+ binding site [chemical binding]; other site 484020002528 Switch I region; other site 484020002529 G2 box; other site 484020002530 G3 box; other site 484020002531 Switch II region; other site 484020002532 G4 box; other site 484020002533 G5 box; other site 484020002534 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 484020002535 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 484020002536 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 484020002537 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 484020002538 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 484020002539 active site 484020002540 dimer interface [polypeptide binding]; other site 484020002541 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 484020002542 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 484020002543 active site 484020002544 FMN binding site [chemical binding]; other site 484020002545 substrate binding site [chemical binding]; other site 484020002546 3Fe-4S cluster binding site [ion binding]; other site 484020002547 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 484020002548 domain interface; other site 484020002549 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 484020002550 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484020002551 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 484020002552 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 484020002553 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 484020002554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020002555 Walker A/P-loop; other site 484020002556 ATP binding site [chemical binding]; other site 484020002557 Q-loop/lid; other site 484020002558 ABC transporter signature motif; other site 484020002559 Walker B; other site 484020002560 D-loop; other site 484020002561 H-loop/switch region; other site 484020002562 Predicted amidohydrolase [General function prediction only]; Region: COG0388 484020002563 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 484020002564 putative active site [active] 484020002565 catalytic triad [active] 484020002566 putative dimer interface [polypeptide binding]; other site 484020002567 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 484020002568 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 484020002569 active site 484020002570 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 484020002571 Integrase core domain; Region: rve; pfam00665 484020002572 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484020002573 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020002574 ATP binding site [chemical binding]; other site 484020002575 putative Mg++ binding site [ion binding]; other site 484020002576 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 484020002577 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020002578 nucleotide binding region [chemical binding]; other site 484020002579 ATP-binding site [chemical binding]; other site 484020002580 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 484020002581 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 484020002582 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 484020002583 Family description; Region: UvrD_C_2; pfam13538 484020002584 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020002585 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 484020002586 Walker A/P-loop; other site 484020002587 ATP binding site [chemical binding]; other site 484020002588 AAA domain; Region: AAA_21; pfam13304 484020002589 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020002590 Q-loop/lid; other site 484020002591 ABC transporter signature motif; other site 484020002592 Walker B; other site 484020002593 D-loop; other site 484020002594 H-loop/switch region; other site 484020002595 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 484020002596 active site 484020002597 Uncharacterized conserved protein [Function unknown]; Region: COG1479 484020002598 Protein of unknown function DUF262; Region: DUF262; pfam03235 484020002599 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 484020002600 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 484020002601 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 484020002602 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 484020002603 Predicted permeases [General function prediction only]; Region: RarD; COG2962 484020002604 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 484020002605 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484020002606 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 484020002607 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020002608 S-adenosylmethionine binding site [chemical binding]; other site 484020002609 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484020002610 catalytic core [active] 484020002611 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 484020002612 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 484020002613 THF binding site; other site 484020002614 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 484020002615 substrate binding site [chemical binding]; other site 484020002616 THF binding site; other site 484020002617 zinc-binding site [ion binding]; other site 484020002618 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 484020002619 FAD binding site [chemical binding]; other site 484020002620 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 484020002621 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 484020002622 metal binding triad; other site 484020002623 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 484020002624 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 484020002625 metal binding triad; other site 484020002626 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 484020002627 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 484020002628 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 484020002629 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 484020002630 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 484020002631 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 484020002632 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 484020002633 dihydroorotase; Validated; Region: pyrC; PRK09357 484020002634 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 484020002635 active site 484020002636 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 484020002637 active site 484020002638 dimer interface [polypeptide binding]; other site 484020002639 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 484020002640 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 484020002641 FAD binding pocket [chemical binding]; other site 484020002642 FAD binding motif [chemical binding]; other site 484020002643 phosphate binding motif [ion binding]; other site 484020002644 beta-alpha-beta structure motif; other site 484020002645 NAD binding pocket [chemical binding]; other site 484020002646 Iron coordination center [ion binding]; other site 484020002647 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 484020002648 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 484020002649 heterodimer interface [polypeptide binding]; other site 484020002650 active site 484020002651 FMN binding site [chemical binding]; other site 484020002652 homodimer interface [polypeptide binding]; other site 484020002653 substrate binding site [chemical binding]; other site 484020002654 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484020002655 active site 484020002656 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 484020002657 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 484020002658 DNA binding residues [nucleotide binding] 484020002659 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 484020002660 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 484020002661 catalytic Zn binding site [ion binding]; other site 484020002662 NAD(P) binding site [chemical binding]; other site 484020002663 structural Zn binding site [ion binding]; other site 484020002664 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020002665 Walker A/P-loop; other site 484020002666 ATP binding site [chemical binding]; other site 484020002667 Q-loop/lid; other site 484020002668 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020002669 ABC transporter signature motif; other site 484020002670 Walker B; other site 484020002671 D-loop; other site 484020002672 H-loop/switch region; other site 484020002673 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020002674 AAA domain; Region: AAA_21; pfam13304 484020002675 Walker A/P-loop; other site 484020002676 ATP binding site [chemical binding]; other site 484020002677 Q-loop/lid; other site 484020002678 ABC transporter signature motif; other site 484020002679 Walker B; other site 484020002680 D-loop; other site 484020002681 H-loop/switch region; other site 484020002682 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 484020002683 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 484020002684 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 484020002685 classical (c) SDRs; Region: SDR_c; cd05233 484020002686 NAD(P) binding site [chemical binding]; other site 484020002687 active site 484020002688 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 484020002689 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 484020002690 minor groove reading motif; other site 484020002691 helix-hairpin-helix signature motif; other site 484020002692 active site 484020002693 Predicted transcriptional regulators [Transcription]; Region: COG1695 484020002694 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 484020002695 Membrane transport protein; Region: Mem_trans; cl09117 484020002696 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 484020002697 HipA N-terminal domain; Region: Couple_hipA; pfam13657 484020002698 HipA-like N-terminal domain; Region: HipA_N; pfam07805 484020002699 HipA-like C-terminal domain; Region: HipA_C; pfam07804 484020002700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484020002701 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020002702 non-specific DNA binding site [nucleotide binding]; other site 484020002703 salt bridge; other site 484020002704 sequence-specific DNA binding site [nucleotide binding]; other site 484020002705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020002706 S-adenosylmethionine binding site [chemical binding]; other site 484020002707 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 484020002708 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484020002709 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 484020002710 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484020002711 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484020002712 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 484020002713 dimerization interface [polypeptide binding]; other site 484020002714 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 484020002715 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 484020002716 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020002717 motif II; other site 484020002718 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 484020002719 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 484020002720 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 484020002721 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 484020002722 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484020002723 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484020002724 catalytic tetrad [active] 484020002725 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484020002726 active site 484020002727 Predicted transcriptional regulator [Transcription]; Region: COG2378 484020002728 WYL domain; Region: WYL; pfam13280 484020002729 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484020002730 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020002731 ATP binding site [chemical binding]; other site 484020002732 putative Mg++ binding site [ion binding]; other site 484020002733 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020002734 nucleotide binding region [chemical binding]; other site 484020002735 ATP-binding site [chemical binding]; other site 484020002736 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 484020002737 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 484020002738 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 484020002739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020002740 motif II; other site 484020002741 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 484020002742 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484020002743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020002744 non-specific DNA binding site [nucleotide binding]; other site 484020002745 salt bridge; other site 484020002746 sequence-specific DNA binding site [nucleotide binding]; other site 484020002747 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 484020002748 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 484020002749 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 484020002750 DNA binding residues [nucleotide binding] 484020002751 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 484020002752 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 484020002753 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 484020002754 phosphopeptide binding site; other site 484020002755 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 484020002756 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 484020002757 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 484020002758 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 484020002759 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 484020002760 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 484020002761 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 484020002762 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 484020002763 homodimer interface [polypeptide binding]; other site 484020002764 putative metal binding site [ion binding]; other site 484020002765 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 484020002766 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 484020002767 substrate binding site [chemical binding]; other site 484020002768 hexamer interface [polypeptide binding]; other site 484020002769 metal binding site [ion binding]; metal-binding site 484020002770 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 484020002771 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 484020002772 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 484020002773 substrate binding site [chemical binding]; other site 484020002774 active site 484020002775 catalytic residues [active] 484020002776 heterodimer interface [polypeptide binding]; other site 484020002777 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 484020002778 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 484020002779 active site 484020002780 ribulose/triose binding site [chemical binding]; other site 484020002781 phosphate binding site [ion binding]; other site 484020002782 substrate (anthranilate) binding pocket [chemical binding]; other site 484020002783 product (indole) binding pocket [chemical binding]; other site 484020002784 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 484020002785 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020002786 catalytic residue [active] 484020002787 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 484020002788 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 484020002789 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 484020002790 G1 box; other site 484020002791 GTP/Mg2+ binding site [chemical binding]; other site 484020002792 Switch I region; other site 484020002793 G2 box; other site 484020002794 Switch II region; other site 484020002795 G3 box; other site 484020002796 G4 box; other site 484020002797 G5 box; other site 484020002798 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 484020002799 G1 box; other site 484020002800 GTP/Mg2+ binding site [chemical binding]; other site 484020002801 Switch I region; other site 484020002802 G2 box; other site 484020002803 G3 box; other site 484020002804 Switch II region; other site 484020002805 G4 box; other site 484020002806 G5 box; other site 484020002807 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 484020002808 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484020002809 RNA binding surface [nucleotide binding]; other site 484020002810 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 484020002811 active site 484020002812 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 484020002813 amphipathic channel; other site 484020002814 Asn-Pro-Ala signature motifs; other site 484020002815 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 484020002816 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 484020002817 purine monophosphate binding site [chemical binding]; other site 484020002818 dimer interface [polypeptide binding]; other site 484020002819 putative catalytic residues [active] 484020002820 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 484020002821 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 484020002822 CoA binding domain; Region: CoA_binding; smart00881 484020002823 CoA-ligase; Region: Ligase_CoA; pfam00549 484020002824 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 484020002825 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 484020002826 CoA-ligase; Region: Ligase_CoA; pfam00549 484020002827 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484020002828 active site 484020002829 Preprotein translocase subunit; Region: YajC; pfam02699 484020002830 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 484020002831 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020002832 Walker A motif; other site 484020002833 ATP binding site [chemical binding]; other site 484020002834 Walker B motif; other site 484020002835 arginine finger; other site 484020002836 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 484020002837 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 484020002838 RuvA N terminal domain; Region: RuvA_N; pfam01330 484020002839 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 484020002840 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 484020002841 active site 484020002842 putative DNA-binding cleft [nucleotide binding]; other site 484020002843 dimer interface [polypeptide binding]; other site 484020002844 hypothetical protein; Validated; Region: PRK00110 484020002845 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020002846 sugar binding site [chemical binding]; other site 484020002847 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 484020002848 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 484020002849 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 484020002850 active site 484020002851 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 484020002852 thiS-thiF/thiG interaction site; other site 484020002853 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 484020002854 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 484020002855 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 484020002856 active site 484020002857 dimer interface [polypeptide binding]; other site 484020002858 motif 1; other site 484020002859 motif 2; other site 484020002860 motif 3; other site 484020002861 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 484020002862 anticodon binding site; other site 484020002863 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 484020002864 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 484020002865 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 484020002866 PAC2 family; Region: PAC2; pfam09754 484020002867 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 484020002868 Phosphotransferase enzyme family; Region: APH; pfam01636 484020002869 Fructosamine kinase; Region: Fructosamin_kin; cl17579 484020002870 chaperone protein DnaJ; Provisional; Region: PRK14278 484020002871 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 484020002872 HSP70 interaction site [polypeptide binding]; other site 484020002873 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 484020002874 Zn binding sites [ion binding]; other site 484020002875 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 484020002876 dimer interface [polypeptide binding]; other site 484020002877 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 484020002878 HTH domain; Region: HTH_11; pfam08279 484020002879 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 484020002880 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 484020002881 TPP-binding site [chemical binding]; other site 484020002882 dimer interface [polypeptide binding]; other site 484020002883 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484020002884 PYR/PP interface [polypeptide binding]; other site 484020002885 dimer interface [polypeptide binding]; other site 484020002886 TPP binding site [chemical binding]; other site 484020002887 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484020002888 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 484020002889 putative active site [active] 484020002890 transaldolase; Provisional; Region: PRK03903 484020002891 catalytic residue [active] 484020002892 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 484020002893 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 484020002894 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 484020002895 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 484020002896 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 484020002897 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020002898 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 484020002899 active site 484020002900 motif I; other site 484020002901 motif II; other site 484020002902 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484020002903 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 484020002904 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484020002905 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 484020002906 NAD binding site [chemical binding]; other site 484020002907 dimer interface [polypeptide binding]; other site 484020002908 substrate binding site [chemical binding]; other site 484020002909 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 484020002910 triosephosphate isomerase; Provisional; Region: PRK14567 484020002911 substrate binding site [chemical binding]; other site 484020002912 dimer interface [polypeptide binding]; other site 484020002913 catalytic triad [active] 484020002914 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 484020002915 Phosphoglycerate kinase; Region: PGK; pfam00162 484020002916 substrate binding site [chemical binding]; other site 484020002917 hinge regions; other site 484020002918 ADP binding site [chemical binding]; other site 484020002919 catalytic site [active] 484020002920 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 484020002921 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 484020002922 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 484020002923 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 484020002924 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 484020002925 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 484020002926 shikimate binding site; other site 484020002927 NAD(P) binding site [chemical binding]; other site 484020002928 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 484020002929 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 484020002930 GIY-YIG motif/motif A; other site 484020002931 active site 484020002932 catalytic site [active] 484020002933 putative DNA binding site [nucleotide binding]; other site 484020002934 metal binding site [ion binding]; metal-binding site 484020002935 UvrB/uvrC motif; Region: UVR; pfam02151 484020002936 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 484020002937 Helix-hairpin-helix motif; Region: HHH; pfam00633 484020002938 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 484020002939 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 484020002940 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 484020002941 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 484020002942 FtsX-like permease family; Region: FtsX; pfam02687 484020002943 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484020002944 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020002945 active site 484020002946 phosphorylation site [posttranslational modification] 484020002947 intermolecular recognition site; other site 484020002948 dimerization interface [polypeptide binding]; other site 484020002949 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484020002950 DNA binding site [nucleotide binding] 484020002951 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484020002952 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 484020002953 dimerization interface [polypeptide binding]; other site 484020002954 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484020002955 dimer interface [polypeptide binding]; other site 484020002956 phosphorylation site [posttranslational modification] 484020002957 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020002958 ATP binding site [chemical binding]; other site 484020002959 Mg2+ binding site [ion binding]; other site 484020002960 G-X-G motif; other site 484020002961 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 484020002962 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 484020002963 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484020002964 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484020002965 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484020002966 UDP-glucose 4-epimerase; Region: PLN02240 484020002967 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 484020002968 NAD binding site [chemical binding]; other site 484020002969 homodimer interface [polypeptide binding]; other site 484020002970 active site 484020002971 substrate binding site [chemical binding]; other site 484020002972 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 484020002973 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 484020002974 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 484020002975 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 484020002976 Phosphotransferase enzyme family; Region: APH; pfam01636 484020002977 active site 484020002978 substrate binding site [chemical binding]; other site 484020002979 ATP binding site [chemical binding]; other site 484020002980 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484020002981 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484020002982 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 484020002983 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484020002984 nucleotide binding site [chemical binding]; other site 484020002985 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 484020002986 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 484020002987 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 484020002988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020002989 dimer interface [polypeptide binding]; other site 484020002990 conserved gate region; other site 484020002991 putative PBP binding loops; other site 484020002992 ABC-ATPase subunit interface; other site 484020002993 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020002994 dimer interface [polypeptide binding]; other site 484020002995 conserved gate region; other site 484020002996 ABC-ATPase subunit interface; other site 484020002997 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 484020002998 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 484020002999 anthranilate synthase component I; Provisional; Region: PRK13571 484020003000 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 484020003001 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 484020003002 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 484020003003 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 484020003004 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 484020003005 substrate binding site [chemical binding]; other site 484020003006 glutamase interaction surface [polypeptide binding]; other site 484020003007 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 484020003008 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484020003009 FeS/SAM binding site; other site 484020003010 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 484020003011 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 484020003012 ribosome recycling factor; Reviewed; Region: frr; PRK00083 484020003013 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 484020003014 hinge region; other site 484020003015 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 484020003016 putative nucleotide binding site [chemical binding]; other site 484020003017 uridine monophosphate binding site [chemical binding]; other site 484020003018 homohexameric interface [polypeptide binding]; other site 484020003019 elongation factor Ts; Provisional; Region: tsf; PRK09377 484020003020 UBA/TS-N domain; Region: UBA; pfam00627 484020003021 Elongation factor TS; Region: EF_TS; pfam00889 484020003022 Elongation factor TS; Region: EF_TS; pfam00889 484020003023 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 484020003024 rRNA interaction site [nucleotide binding]; other site 484020003025 S8 interaction site; other site 484020003026 putative laminin-1 binding site; other site 484020003027 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 484020003028 active site 484020003029 catalytic residues [active] 484020003030 metal binding site [ion binding]; metal-binding site 484020003031 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 484020003032 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484020003033 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 484020003034 acyl-activating enzyme (AAE) consensus motif; other site 484020003035 putative AMP binding site [chemical binding]; other site 484020003036 putative active site [active] 484020003037 putative CoA binding site [chemical binding]; other site 484020003038 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 484020003039 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 484020003040 active site 484020003041 isocitrate dehydrogenase; Validated; Region: PRK08299 484020003042 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 484020003043 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 484020003044 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 484020003045 acyl-activating enzyme (AAE) consensus motif; other site 484020003046 putative AMP binding site [chemical binding]; other site 484020003047 putative active site [active] 484020003048 putative CoA binding site [chemical binding]; other site 484020003049 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 484020003050 Peptidase family M23; Region: Peptidase_M23; pfam01551 484020003051 UGMP family protein; Validated; Region: PRK09604 484020003052 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 484020003053 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 484020003054 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484020003055 Coenzyme A binding pocket [chemical binding]; other site 484020003056 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 484020003057 Glycoprotease family; Region: Peptidase_M22; pfam00814 484020003058 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 484020003059 hypothetical protein; Reviewed; Region: PRK07914 484020003060 Competence protein; Region: Competence; pfam03772 484020003061 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 484020003062 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 484020003063 Helix-hairpin-helix motif; Region: HHH; pfam00633 484020003064 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 484020003065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484020003066 active site 484020003067 HIGH motif; other site 484020003068 nucleotide binding site [chemical binding]; other site 484020003069 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484020003070 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 484020003071 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484020003072 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484020003073 active site 484020003074 KMSKS motif; other site 484020003075 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 484020003076 tRNA binding surface [nucleotide binding]; other site 484020003077 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 484020003078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 484020003079 substrate binding pocket [chemical binding]; other site 484020003080 membrane-bound complex binding site; other site 484020003081 hinge residues; other site 484020003082 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 484020003083 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 484020003084 Cl binding site [ion binding]; other site 484020003085 oligomer interface [polypeptide binding]; other site 484020003086 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484020003087 catalytic core [active] 484020003088 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 484020003089 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 484020003090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 484020003091 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 484020003092 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 484020003093 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 484020003094 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 484020003095 endonuclease IV; Provisional; Region: PRK01060 484020003096 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 484020003097 AP (apurinic/apyrimidinic) site pocket; other site 484020003098 DNA interaction; other site 484020003099 Metal-binding active site; metal-binding site 484020003100 Uncharacterized conserved protein [Function unknown]; Region: COG3189 484020003101 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 484020003102 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 484020003103 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484020003104 Coenzyme A binding pocket [chemical binding]; other site 484020003105 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 484020003106 Predicted amidohydrolase [General function prediction only]; Region: COG0388 484020003107 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 484020003108 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 484020003109 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 484020003110 Coenzyme A binding pocket [chemical binding]; other site 484020003111 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 484020003112 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 484020003113 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 484020003114 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484020003115 H+ Antiporter protein; Region: 2A0121; TIGR00900 484020003116 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 484020003117 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 484020003118 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 484020003119 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 484020003120 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484020003121 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 484020003122 DNA binding site [nucleotide binding] 484020003123 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 484020003124 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 484020003125 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 484020003126 FMN binding site [chemical binding]; other site 484020003127 dimer interface [polypeptide binding]; other site 484020003128 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 484020003129 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 484020003130 active site 484020003131 catalytic site [active] 484020003132 Bacterial PH domain; Region: DUF304; pfam03703 484020003133 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484020003134 catalytic core [active] 484020003135 Oligomerisation domain; Region: Oligomerisation; pfam02410 484020003136 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 484020003137 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 484020003138 Substrate binding site; other site 484020003139 Mg++ binding site; other site 484020003140 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 484020003141 active site 484020003142 substrate binding site [chemical binding]; other site 484020003143 CoA binding site [chemical binding]; other site 484020003144 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 484020003145 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 484020003146 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484020003147 active site 484020003148 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 484020003149 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 484020003150 active site 484020003151 (T/H)XGH motif; other site 484020003152 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 484020003153 putative catalytic cysteine [active] 484020003154 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 484020003155 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 484020003156 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020003157 catalytic residue [active] 484020003158 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 484020003159 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 484020003160 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484020003161 Walker A/P-loop; other site 484020003162 ATP binding site [chemical binding]; other site 484020003163 Q-loop/lid; other site 484020003164 ABC transporter signature motif; other site 484020003165 Walker B; other site 484020003166 D-loop; other site 484020003167 H-loop/switch region; other site 484020003168 Predicted transcriptional regulators [Transcription]; Region: COG1725 484020003169 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484020003170 DNA-binding site [nucleotide binding]; DNA binding site 484020003171 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 484020003172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020003173 motif II; other site 484020003174 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 484020003175 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 484020003176 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 484020003177 Walker A/P-loop; other site 484020003178 ATP binding site [chemical binding]; other site 484020003179 Q-loop/lid; other site 484020003180 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 484020003181 ABC transporter signature motif; other site 484020003182 Walker B; other site 484020003183 D-loop; other site 484020003184 H-loop/switch region; other site 484020003185 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 484020003186 ATP-NAD kinase; Region: NAD_kinase; pfam01513 484020003187 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 484020003188 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 484020003189 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 484020003190 TrkA-N domain; Region: TrkA_N; pfam02254 484020003191 TrkA-C domain; Region: TrkA_C; pfam02080 484020003192 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 484020003193 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484020003194 RNA binding surface [nucleotide binding]; other site 484020003195 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020003196 S-adenosylmethionine binding site [chemical binding]; other site 484020003197 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 484020003198 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020003199 active site 484020003200 motif I; other site 484020003201 motif II; other site 484020003202 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020003203 motif II; other site 484020003204 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 484020003205 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 484020003206 active site 484020003207 HIGH motif; other site 484020003208 dimer interface [polypeptide binding]; other site 484020003209 KMSKS motif; other site 484020003210 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 484020003211 RNA binding surface [nucleotide binding]; other site 484020003212 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 484020003213 Predicted membrane protein [Function unknown]; Region: COG4905 484020003214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484020003215 Zn2+ binding site [ion binding]; other site 484020003216 Mg2+ binding site [ion binding]; other site 484020003217 argininosuccinate lyase; Provisional; Region: PRK00855 484020003218 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 484020003219 active sites [active] 484020003220 tetramer interface [polypeptide binding]; other site 484020003221 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 484020003222 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 484020003223 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020003224 ATP binding site [chemical binding]; other site 484020003225 putative Mg++ binding site [ion binding]; other site 484020003226 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 484020003227 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 484020003228 Divergent AAA domain; Region: AAA_4; pfam04326 484020003229 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 484020003230 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 484020003231 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 484020003232 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 484020003233 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 484020003234 HsdM N-terminal domain; Region: HsdM_N; pfam12161 484020003235 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 484020003236 Methyltransferase domain; Region: Methyltransf_26; pfam13659 484020003237 Predicted prefoldin, molecular chaperone implicated in de novo protein folding [Posttranslational modification, protein turnover, chaperones]; Region: GIM5; COG1730 484020003238 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 484020003239 catalytic site [active] 484020003240 metal binding site [ion binding]; metal-binding site 484020003241 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 484020003242 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 484020003243 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 484020003244 Int/Topo IB signature motif; other site 484020003245 argininosuccinate synthase; Provisional; Region: PRK13820 484020003246 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 484020003247 ANP binding site [chemical binding]; other site 484020003248 Substrate Binding Site II [chemical binding]; other site 484020003249 Substrate Binding Site I [chemical binding]; other site 484020003250 arginine repressor; Provisional; Region: PRK03341 484020003251 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 484020003252 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 484020003253 ornithine carbamoyltransferase; Provisional; Region: PRK00779 484020003254 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 484020003255 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 484020003256 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 484020003257 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 484020003258 inhibitor-cofactor binding pocket; inhibition site 484020003259 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020003260 catalytic residue [active] 484020003261 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 484020003262 feedback inhibition sensing region; other site 484020003263 homohexameric interface [polypeptide binding]; other site 484020003264 nucleotide binding site [chemical binding]; other site 484020003265 N-acetyl-L-glutamate binding site [chemical binding]; other site 484020003266 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 484020003267 heterotetramer interface [polypeptide binding]; other site 484020003268 active site pocket [active] 484020003269 cleavage site 484020003270 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 484020003271 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 484020003272 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 484020003273 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 484020003274 putative tRNA-binding site [nucleotide binding]; other site 484020003275 B3/4 domain; Region: B3_4; pfam03483 484020003276 tRNA synthetase B5 domain; Region: B5; pfam03484 484020003277 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 484020003278 dimer interface [polypeptide binding]; other site 484020003279 motif 1; other site 484020003280 motif 3; other site 484020003281 motif 2; other site 484020003282 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 484020003283 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 484020003284 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 484020003285 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 484020003286 dimer interface [polypeptide binding]; other site 484020003287 motif 1; other site 484020003288 active site 484020003289 motif 2; other site 484020003290 motif 3; other site 484020003291 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 484020003292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020003293 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 484020003294 Walker A/P-loop; other site 484020003295 ATP binding site [chemical binding]; other site 484020003296 Q-loop/lid; other site 484020003297 ABC transporter signature motif; other site 484020003298 Walker B; other site 484020003299 D-loop; other site 484020003300 H-loop/switch region; other site 484020003301 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 484020003302 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484020003303 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 484020003304 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 484020003305 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484020003306 catalytic core [active] 484020003307 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 484020003308 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 484020003309 catalytic site [active] 484020003310 Predicted membrane protein [Function unknown]; Region: COG2855 484020003311 Transcriptional regulator [Transcription]; Region: LysR; COG0583 484020003312 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 484020003313 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484020003314 dimerization interface [polypeptide binding]; other site 484020003315 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484020003316 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 484020003317 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484020003318 active site 484020003319 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 484020003320 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 484020003321 Double zinc ribbon; Region: DZR; pfam12773 484020003322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 484020003323 PASTA domain; Region: PASTA; smart00740 484020003324 Predicted esterase [General function prediction only]; Region: COG0400 484020003325 putative hydrolase; Provisional; Region: PRK11460 484020003326 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 484020003327 active site 484020003328 catalytic residues [active] 484020003329 metal binding site [ion binding]; metal-binding site 484020003330 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 484020003331 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 484020003332 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 484020003333 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 484020003334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020003335 non-specific DNA binding site [nucleotide binding]; other site 484020003336 salt bridge; other site 484020003337 sequence-specific DNA binding site [nucleotide binding]; other site 484020003338 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 484020003339 Short C-terminal domain; Region: SHOCT; pfam09851 484020003340 Protein of unknown function, DUF485; Region: DUF485; pfam04341 484020003341 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020003342 sequence-specific DNA binding site [nucleotide binding]; other site 484020003343 salt bridge; other site 484020003344 Protein kinase domain; Region: Pkinase; pfam00069 484020003345 Catalytic domain of Protein Kinases; Region: PKc; cd00180 484020003346 active site 484020003347 ATP binding site [chemical binding]; other site 484020003348 substrate binding site [chemical binding]; other site 484020003349 activation loop (A-loop); other site 484020003350 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 484020003351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020003352 S-adenosylmethionine binding site [chemical binding]; other site 484020003353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484020003354 hypothetical protein; Provisional; Region: PRK11770 484020003355 Domain of unknown function (DUF307); Region: DUF307; pfam03733 484020003356 Domain of unknown function (DUF307); Region: DUF307; pfam03733 484020003357 Fic family protein [Function unknown]; Region: COG3177 484020003358 Fic/DOC family; Region: Fic; pfam02661 484020003359 GTP-binding protein YchF; Reviewed; Region: PRK09601 484020003360 YchF GTPase; Region: YchF; cd01900 484020003361 G1 box; other site 484020003362 GTP/Mg2+ binding site [chemical binding]; other site 484020003363 Switch I region; other site 484020003364 G2 box; other site 484020003365 Switch II region; other site 484020003366 G3 box; other site 484020003367 G4 box; other site 484020003368 G5 box; other site 484020003369 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 484020003370 transaminase; Reviewed; Region: PRK08068 484020003371 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020003372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020003373 homodimer interface [polypeptide binding]; other site 484020003374 catalytic residue [active] 484020003375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020003376 dimer interface [polypeptide binding]; other site 484020003377 conserved gate region; other site 484020003378 ABC-ATPase subunit interface; other site 484020003379 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 484020003380 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 484020003381 Walker A/P-loop; other site 484020003382 ATP binding site [chemical binding]; other site 484020003383 Q-loop/lid; other site 484020003384 ABC transporter signature motif; other site 484020003385 Walker B; other site 484020003386 D-loop; other site 484020003387 H-loop/switch region; other site 484020003388 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 484020003389 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 484020003390 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 484020003391 alpha subunit interface [polypeptide binding]; other site 484020003392 TPP binding site [chemical binding]; other site 484020003393 heterodimer interface [polypeptide binding]; other site 484020003394 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484020003395 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 484020003396 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 484020003397 tetramer interface [polypeptide binding]; other site 484020003398 TPP-binding site [chemical binding]; other site 484020003399 heterodimer interface [polypeptide binding]; other site 484020003400 phosphorylation loop region [posttranslational modification] 484020003401 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 484020003402 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 484020003403 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 484020003404 catalytic nucleophile [active] 484020003405 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 484020003406 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 484020003407 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 484020003408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 484020003409 Histidine kinase; Region: HisKA_3; pfam07730 484020003410 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020003411 ATP binding site [chemical binding]; other site 484020003412 Mg2+ binding site [ion binding]; other site 484020003413 G-X-G motif; other site 484020003414 Histidine kinase; Region: HisKA_3; pfam07730 484020003415 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484020003416 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020003417 active site 484020003418 phosphorylation site [posttranslational modification] 484020003419 intermolecular recognition site; other site 484020003420 dimerization interface [polypeptide binding]; other site 484020003421 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484020003422 dimerization interface [polypeptide binding]; other site 484020003423 DNA binding residues [nucleotide binding] 484020003424 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 484020003425 active site 484020003426 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 484020003427 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 484020003428 active site 484020003429 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 484020003430 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484020003431 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 484020003432 FtsX-like permease family; Region: FtsX; pfam02687 484020003433 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484020003434 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484020003435 Walker A/P-loop; other site 484020003436 ATP binding site [chemical binding]; other site 484020003437 Q-loop/lid; other site 484020003438 ABC transporter signature motif; other site 484020003439 Walker B; other site 484020003440 D-loop; other site 484020003441 H-loop/switch region; other site 484020003442 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 484020003443 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 484020003444 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 484020003445 homodimer interface [polypeptide binding]; other site 484020003446 substrate-cofactor binding pocket; other site 484020003447 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020003448 catalytic residue [active] 484020003449 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 484020003450 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 484020003451 dimer interface [polypeptide binding]; other site 484020003452 pyridoxal binding site [chemical binding]; other site 484020003453 ATP binding site [chemical binding]; other site 484020003454 fumarate reductase, flavoprotein subunit; Region: fum_red_Fp; TIGR01176 484020003455 L-aspartate oxidase; Provisional; Region: PRK06175 484020003456 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 484020003457 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 484020003458 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 484020003459 active site 484020003460 DNA binding site [nucleotide binding] 484020003461 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 484020003462 DNA protecting protein DprA; Region: dprA; TIGR00732 484020003463 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 484020003464 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 484020003465 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020003466 Walker A motif; other site 484020003467 ATP binding site [chemical binding]; other site 484020003468 Walker B motif; other site 484020003469 arginine finger; other site 484020003470 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 484020003471 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 484020003472 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 484020003473 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 484020003474 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 484020003475 Methyltransferase domain; Region: Methyltransf_18; pfam12847 484020003476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 484020003477 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 484020003478 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 484020003479 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 484020003480 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020003481 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020003482 homodimer interface [polypeptide binding]; other site 484020003483 catalytic residue [active] 484020003484 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 484020003485 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 484020003486 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020003487 Walker A motif; other site 484020003488 ATP binding site [chemical binding]; other site 484020003489 Walker B motif; other site 484020003490 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 484020003491 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 484020003492 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 484020003493 oligomer interface [polypeptide binding]; other site 484020003494 active site residues [active] 484020003495 Clp protease; Region: CLP_protease; pfam00574 484020003496 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 484020003497 oligomer interface [polypeptide binding]; other site 484020003498 active site residues [active] 484020003499 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 484020003500 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 484020003501 putative ion selectivity filter; other site 484020003502 putative pore gating glutamate residue; other site 484020003503 trigger factor; Provisional; Region: tig; PRK01490 484020003504 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 484020003505 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 484020003506 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 484020003507 active site 484020003508 substrate binding site [chemical binding]; other site 484020003509 catalytic site [active] 484020003510 HRDC domain; Region: HRDC; pfam00570 484020003511 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 484020003512 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 484020003513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484020003514 FeS/SAM binding site; other site 484020003515 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 484020003516 Pyruvate formate lyase 1; Region: PFL1; cd01678 484020003517 coenzyme A binding site [chemical binding]; other site 484020003518 active site 484020003519 catalytic residues [active] 484020003520 glycine loop; other site 484020003521 NAD synthetase; Provisional; Region: PRK13981 484020003522 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 484020003523 multimer interface [polypeptide binding]; other site 484020003524 active site 484020003525 catalytic triad [active] 484020003526 protein interface 1 [polypeptide binding]; other site 484020003527 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 484020003528 homodimer interface [polypeptide binding]; other site 484020003529 NAD binding pocket [chemical binding]; other site 484020003530 ATP binding pocket [chemical binding]; other site 484020003531 Mg binding site [ion binding]; other site 484020003532 active-site loop [active] 484020003533 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 484020003534 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 484020003535 metal binding site [ion binding]; metal-binding site 484020003536 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020003537 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 484020003538 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020003539 active site 484020003540 motif I; other site 484020003541 motif II; other site 484020003542 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 484020003543 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 484020003544 active site 484020003545 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 484020003546 Helix-turn-helix domain; Region: HTH_36; pfam13730 484020003547 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 484020003548 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484020003549 P-loop; other site 484020003550 Magnesium ion binding site [ion binding]; other site 484020003551 HipA-like C-terminal domain; Region: HipA_C; pfam07804 484020003552 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 484020003553 non-specific DNA binding site [nucleotide binding]; other site 484020003554 salt bridge; other site 484020003555 sequence-specific DNA binding site [nucleotide binding]; other site 484020003556 DNA topoisomerase III; Provisional; Region: PRK07726 484020003557 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 484020003558 active site 484020003559 putative interdomain interaction site [polypeptide binding]; other site 484020003560 putative metal-binding site [ion binding]; other site 484020003561 putative nucleotide binding site [chemical binding]; other site 484020003562 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 484020003563 domain I; other site 484020003564 DNA binding groove [nucleotide binding] 484020003565 phosphate binding site [ion binding]; other site 484020003566 domain II; other site 484020003567 domain III; other site 484020003568 nucleotide binding site [chemical binding]; other site 484020003569 catalytic site [active] 484020003570 domain IV; other site 484020003571 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 484020003572 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 484020003573 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 484020003574 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 484020003575 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 484020003576 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 484020003577 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020003578 S-adenosylmethionine binding site [chemical binding]; other site 484020003579 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 484020003580 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 484020003581 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 484020003582 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 484020003583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020003584 nucleotide binding region [chemical binding]; other site 484020003585 ATP-binding site [chemical binding]; other site 484020003586 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 484020003587 Adenoviral DNA terminal protein; Region: Adeno_terminal; pfam02459 484020003588 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 484020003589 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484020003590 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484020003591 catalytic residue [active] 484020003592 CHAP domain; Region: CHAP; pfam05257 484020003593 AAA-like domain; Region: AAA_10; pfam12846 484020003594 Domain of unknown function DUF87; Region: DUF87; pfam01935 484020003595 PrgI family protein; Region: PrgI; pfam12666 484020003596 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 484020003597 EcsC protein family; Region: EcsC; pfam12787 484020003598 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 484020003599 FIC domain binding interface [polypeptide binding]; other site 484020003600 Fic/DOC family; Region: Fic; cl00960 484020003601 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 484020003602 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484020003603 active site 484020003604 DNA binding site [nucleotide binding] 484020003605 Int/Topo IB signature motif; other site 484020003606 RelB antitoxin; Region: RelB; cl01171 484020003607 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 484020003608 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484020003609 Zn2+ binding site [ion binding]; other site 484020003610 Mg2+ binding site [ion binding]; other site 484020003611 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 484020003612 synthetase active site [active] 484020003613 NTP binding site [chemical binding]; other site 484020003614 metal binding site [ion binding]; metal-binding site 484020003615 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 484020003616 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 484020003617 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 484020003618 trimer interface [polypeptide binding]; other site 484020003619 active site 484020003620 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 484020003621 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 484020003622 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 484020003623 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 484020003624 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 484020003625 CAP-like domain; other site 484020003626 active site 484020003627 primary dimer interface [polypeptide binding]; other site 484020003628 DEAD-like helicases superfamily; Region: DEXDc; smart00487 484020003629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020003630 ATP binding site [chemical binding]; other site 484020003631 putative Mg++ binding site [ion binding]; other site 484020003632 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 484020003633 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020003634 nucleotide binding region [chemical binding]; other site 484020003635 ATP-binding site [chemical binding]; other site 484020003636 DEAD/H associated; Region: DEAD_assoc; pfam08494 484020003637 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020003638 salt bridge; other site 484020003639 non-specific DNA binding site [nucleotide binding]; other site 484020003640 sequence-specific DNA binding site [nucleotide binding]; other site 484020003641 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 484020003642 Aspartase; Region: Aspartase; cd01357 484020003643 active sites [active] 484020003644 tetramer interface [polypeptide binding]; other site 484020003645 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020003646 ATP binding site [chemical binding]; other site 484020003647 Mg2+ binding site [ion binding]; other site 484020003648 G-X-G motif; other site 484020003649 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 484020003650 anchoring element; other site 484020003651 dimer interface [polypeptide binding]; other site 484020003652 ATP binding site [chemical binding]; other site 484020003653 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 484020003654 active site 484020003655 metal binding site [ion binding]; metal-binding site 484020003656 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 484020003657 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 484020003658 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 484020003659 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 484020003660 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 484020003661 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 484020003662 DNA binding residues [nucleotide binding] 484020003663 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 484020003664 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 484020003665 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 484020003666 substrate binding pocket [chemical binding]; other site 484020003667 chain length determination region; other site 484020003668 substrate-Mg2+ binding site; other site 484020003669 catalytic residues [active] 484020003670 aspartate-rich region 1; other site 484020003671 active site lid residues [active] 484020003672 aspartate-rich region 2; other site 484020003673 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 484020003674 Catalytic domain of Protein Kinases; Region: PKc; cd00180 484020003675 active site 484020003676 ATP binding site [chemical binding]; other site 484020003677 substrate binding site [chemical binding]; other site 484020003678 activation loop (A-loop); other site 484020003679 PASTA domain; Region: PASTA; pfam03793 484020003680 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 484020003681 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 484020003682 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 484020003683 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 484020003684 putative acyl-acceptor binding pocket; other site 484020003685 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 484020003686 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 484020003687 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 484020003688 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 484020003689 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 484020003690 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020003691 ATP binding site [chemical binding]; other site 484020003692 putative Mg++ binding site [ion binding]; other site 484020003693 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 484020003694 SEC-C motif; Region: SEC-C; pfam02810 484020003695 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 484020003696 30S subunit binding site; other site 484020003697 recombination regulator RecX; Reviewed; Region: recX; PRK00117 484020003698 recombinase A; Provisional; Region: recA; PRK09354 484020003699 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 484020003700 hexamer interface [polypeptide binding]; other site 484020003701 Walker A motif; other site 484020003702 ATP binding site [chemical binding]; other site 484020003703 Walker B motif; other site 484020003704 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 484020003705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 484020003706 non-specific DNA binding site [nucleotide binding]; other site 484020003707 salt bridge; other site 484020003708 sequence-specific DNA binding site [nucleotide binding]; other site 484020003709 Competence-damaged protein; Region: CinA; pfam02464 484020003710 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 484020003711 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 484020003712 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 484020003713 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 484020003714 Fic/DOC family; Region: Fic; cl00960 484020003715 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 484020003716 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 484020003717 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 484020003718 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 484020003719 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 484020003720 FeS/SAM binding site; other site 484020003721 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 484020003722 synthetase active site [active] 484020003723 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 484020003724 NTP binding site [chemical binding]; other site 484020003725 metal binding site [ion binding]; metal-binding site 484020003726 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484020003727 EamA-like transporter family; Region: EamA; pfam00892 484020003728 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 484020003729 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 484020003730 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 484020003731 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484020003732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020003733 active site 484020003734 phosphorylation site [posttranslational modification] 484020003735 intermolecular recognition site; other site 484020003736 dimerization interface [polypeptide binding]; other site 484020003737 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484020003738 DNA binding residues [nucleotide binding] 484020003739 dimerization interface [polypeptide binding]; other site 484020003740 Protein of unknown function DUF262; Region: DUF262; pfam03235 484020003741 Uncharacterized conserved protein [Function unknown]; Region: COG1479 484020003742 Protein of unknown function DUF262; Region: DUF262; pfam03235 484020003743 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 484020003744 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 484020003745 active site 484020003746 dimer interface [polypeptide binding]; other site 484020003747 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 484020003748 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 484020003749 catalytic site [active] 484020003750 G-X2-G-X-G-K; other site 484020003751 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 484020003752 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484020003753 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484020003754 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 484020003755 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484020003756 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484020003757 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 484020003758 IMP binding site; other site 484020003759 dimer interface [polypeptide binding]; other site 484020003760 interdomain contacts; other site 484020003761 partial ornithine binding site; other site 484020003762 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 484020003763 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 484020003764 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 484020003765 catalytic site [active] 484020003766 subunit interface [polypeptide binding]; other site 484020003767 transcription antitermination factor NusB; Region: nusB; TIGR01951 484020003768 putative RNA binding site [nucleotide binding]; other site 484020003769 elongation factor P; Validated; Region: PRK00529 484020003770 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 484020003771 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 484020003772 RNA binding site [nucleotide binding]; other site 484020003773 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 484020003774 RNA binding site [nucleotide binding]; other site 484020003775 H+ Antiporter protein; Region: 2A0121; TIGR00900 484020003776 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020003777 putative substrate translocation pore; other site 484020003778 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 484020003779 SdiA-regulated; Region: SdiA-regulated; cd09971 484020003780 putative active site [active] 484020003781 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 484020003782 elongation factor Tu; Reviewed; Region: PRK00049 484020003783 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 484020003784 G1 box; other site 484020003785 GEF interaction site [polypeptide binding]; other site 484020003786 GTP/Mg2+ binding site [chemical binding]; other site 484020003787 Switch I region; other site 484020003788 G2 box; other site 484020003789 G3 box; other site 484020003790 Switch II region; other site 484020003791 G4 box; other site 484020003792 G5 box; other site 484020003793 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 484020003794 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 484020003795 Antibiotic Binding Site [chemical binding]; other site 484020003796 elongation factor G; Reviewed; Region: PRK00007 484020003797 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 484020003798 G1 box; other site 484020003799 putative GEF interaction site [polypeptide binding]; other site 484020003800 GTP/Mg2+ binding site [chemical binding]; other site 484020003801 Switch I region; other site 484020003802 G2 box; other site 484020003803 G3 box; other site 484020003804 Switch II region; other site 484020003805 G4 box; other site 484020003806 G5 box; other site 484020003807 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 484020003808 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 484020003809 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 484020003810 30S ribosomal protein S7; Validated; Region: PRK05302 484020003811 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 484020003812 S17 interaction site [polypeptide binding]; other site 484020003813 S8 interaction site; other site 484020003814 16S rRNA interaction site [nucleotide binding]; other site 484020003815 streptomycin interaction site [chemical binding]; other site 484020003816 23S rRNA interaction site [nucleotide binding]; other site 484020003817 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 484020003818 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 484020003819 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484020003820 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484020003821 catalytic residue [active] 484020003822 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 484020003823 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 484020003824 Right handed beta helix region; Region: Beta_helix; pfam13229 484020003825 Disaggregatase related; Region: Disaggr_assoc; pfam08480 484020003826 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 484020003827 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 484020003828 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 484020003829 ATP-grasp domain; Region: ATP-grasp; pfam02222 484020003830 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 484020003831 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 484020003832 ATP binding site [chemical binding]; other site 484020003833 active site 484020003834 substrate binding site [chemical binding]; other site 484020003835 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 484020003836 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 484020003837 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 484020003838 dimerization interface [polypeptide binding]; other site 484020003839 ATP binding site [chemical binding]; other site 484020003840 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 484020003841 dimerization interface [polypeptide binding]; other site 484020003842 ATP binding site [chemical binding]; other site 484020003843 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 484020003844 putative active site [active] 484020003845 catalytic triad [active] 484020003846 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 484020003847 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 484020003848 putative active site [active] 484020003849 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 484020003850 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 484020003851 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 484020003852 DNA polymerase IV; Reviewed; Region: PRK03103 484020003853 Y-family of DNA polymerases; Region: PolY; cl12025 484020003854 active site 484020003855 DNA binding site [nucleotide binding] 484020003856 amidophosphoribosyltransferase; Provisional; Region: PRK07272 484020003857 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 484020003858 active site 484020003859 tetramer interface [polypeptide binding]; other site 484020003860 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484020003861 active site 484020003862 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 484020003863 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 484020003864 dimerization interface [polypeptide binding]; other site 484020003865 putative ATP binding site [chemical binding]; other site 484020003866 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 484020003867 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 484020003868 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 484020003869 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 484020003870 Sulfatase; Region: Sulfatase; pfam00884 484020003871 Putative esterase; Region: Esterase; pfam00756 484020003872 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 484020003873 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 484020003874 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 484020003875 metal binding site [ion binding]; metal-binding site 484020003876 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 484020003877 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 484020003878 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 484020003879 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 484020003880 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 484020003881 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 484020003882 Predicted permeases [General function prediction only]; Region: COG0701 484020003883 TIGR03943 family protein; Region: TIGR03943 484020003884 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 484020003885 metal binding site 2 [ion binding]; metal-binding site 484020003886 putative DNA binding helix; other site 484020003887 metal binding site 1 [ion binding]; metal-binding site 484020003888 dimer interface [polypeptide binding]; other site 484020003889 structural Zn2+ binding site [ion binding]; other site 484020003890 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 484020003891 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 484020003892 NAD binding site [chemical binding]; other site 484020003893 ATP-grasp domain; Region: ATP-grasp; pfam02222 484020003894 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 484020003895 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 484020003896 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 484020003897 NAD(P) binding site [chemical binding]; other site 484020003898 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 484020003899 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 484020003900 TPP-binding site; other site 484020003901 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 484020003902 PYR/PP interface [polypeptide binding]; other site 484020003903 dimer interface [polypeptide binding]; other site 484020003904 TPP binding site [chemical binding]; other site 484020003905 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 484020003906 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 484020003907 metal binding site [ion binding]; metal-binding site 484020003908 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 484020003909 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 484020003910 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 484020003911 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 484020003912 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 484020003913 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 484020003914 putative active site [active] 484020003915 DNA primase, catalytic core; Region: dnaG; TIGR01391 484020003916 CHC2 zinc finger; Region: zf-CHC2; cl17510 484020003917 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 484020003918 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 484020003919 active site 484020003920 metal binding site [ion binding]; metal-binding site 484020003921 interdomain interaction site; other site 484020003922 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 484020003923 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 484020003924 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484020003925 Zn2+ binding site [ion binding]; other site 484020003926 Mg2+ binding site [ion binding]; other site 484020003927 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 484020003928 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 484020003929 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 484020003930 active site 484020003931 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 484020003932 dimer interface [polypeptide binding]; other site 484020003933 substrate binding site [chemical binding]; other site 484020003934 catalytic residues [active] 484020003935 amino acid transporter; Region: 2A0306; TIGR00909 484020003936 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 484020003937 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 484020003938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 484020003939 S-ribosylhomocysteinase; Provisional; Region: PRK02260 484020003940 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 484020003941 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 484020003942 ATP binding site [chemical binding]; other site 484020003943 putative Mg++ binding site [ion binding]; other site 484020003944 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020003945 nucleotide binding region [chemical binding]; other site 484020003946 ATP-binding site [chemical binding]; other site 484020003947 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 484020003948 HRDC domain; Region: HRDC; pfam00570 484020003949 cystathionine gamma-synthase; Provisional; Region: PRK07811 484020003950 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 484020003951 homodimer interface [polypeptide binding]; other site 484020003952 substrate-cofactor binding pocket; other site 484020003953 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020003954 catalytic residue [active] 484020003955 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 484020003956 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 484020003957 dimer interface [polypeptide binding]; other site 484020003958 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020003959 catalytic residue [active] 484020003960 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 484020003961 dimerization interface [polypeptide binding]; other site 484020003962 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 484020003963 NAD binding site [chemical binding]; other site 484020003964 ligand binding site [chemical binding]; other site 484020003965 catalytic site [active] 484020003966 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 484020003967 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484020003968 Walker A/P-loop; other site 484020003969 ATP binding site [chemical binding]; other site 484020003970 Q-loop/lid; other site 484020003971 ABC transporter signature motif; other site 484020003972 Walker B; other site 484020003973 D-loop; other site 484020003974 H-loop/switch region; other site 484020003975 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 484020003976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 484020003977 Walker A/P-loop; other site 484020003978 ATP binding site [chemical binding]; other site 484020003979 Q-loop/lid; other site 484020003980 ABC transporter signature motif; other site 484020003981 Walker B; other site 484020003982 D-loop; other site 484020003983 H-loop/switch region; other site 484020003984 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 484020003985 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020003986 dimer interface [polypeptide binding]; other site 484020003987 conserved gate region; other site 484020003988 putative PBP binding loops; other site 484020003989 ABC-ATPase subunit interface; other site 484020003990 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 484020003991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020003992 dimer interface [polypeptide binding]; other site 484020003993 conserved gate region; other site 484020003994 putative PBP binding loops; other site 484020003995 ABC-ATPase subunit interface; other site 484020003996 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 484020003997 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 484020003998 pantothenate kinase; Reviewed; Region: PRK13318 484020003999 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 484020004000 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 484020004001 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 484020004002 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 484020004003 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 484020004004 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 484020004005 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 484020004006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 484020004007 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 484020004008 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 484020004009 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 484020004010 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020004011 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020004012 DNA binding site [nucleotide binding] 484020004013 domain linker motif; other site 484020004014 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 484020004015 ligand binding site [chemical binding]; other site 484020004016 dimerization interface (open form) [polypeptide binding]; other site 484020004017 dimerization interface (closed form) [polypeptide binding]; other site 484020004018 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 484020004019 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 484020004020 NAD binding site [chemical binding]; other site 484020004021 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 484020004022 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 484020004023 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020004024 sugar binding site [chemical binding]; other site 484020004025 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 484020004026 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 484020004027 HIGH motif; other site 484020004028 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 484020004029 active site 484020004030 KMSKS motif; other site 484020004031 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 484020004032 tRNA binding surface [nucleotide binding]; other site 484020004033 anticodon binding site; other site 484020004034 Membrane protein of unknown function; Region: DUF360; pfam04020 484020004035 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 484020004036 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 484020004037 NAD(P) binding site [chemical binding]; other site 484020004038 catalytic residues [active] 484020004039 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 484020004040 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 484020004041 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 484020004042 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484020004043 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484020004044 catalytic residue [active] 484020004045 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 484020004046 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 484020004047 homodimer interface [polypeptide binding]; other site 484020004048 substrate-cofactor binding pocket; other site 484020004049 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020004050 catalytic residue [active] 484020004051 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 484020004052 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484020004053 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 484020004054 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484020004055 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484020004056 Walker A/P-loop; other site 484020004057 ATP binding site [chemical binding]; other site 484020004058 Q-loop/lid; other site 484020004059 ABC transporter signature motif; other site 484020004060 Walker B; other site 484020004061 D-loop; other site 484020004062 H-loop/switch region; other site 484020004063 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 484020004064 FtsX-like permease family; Region: FtsX; pfam02687 484020004065 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484020004066 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 484020004067 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020004068 motif II; other site 484020004069 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 484020004070 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484020004071 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484020004072 active site 484020004073 catalytic tetrad [active] 484020004074 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 484020004075 active site 484020004076 catalytic site [active] 484020004077 substrate binding site [chemical binding]; other site 484020004078 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 484020004079 Citrate synthase; Region: Citrate_synt; pfam00285 484020004080 oxalacetate binding site [chemical binding]; other site 484020004081 citrylCoA binding site [chemical binding]; other site 484020004082 coenzyme A binding site [chemical binding]; other site 484020004083 catalytic triad [active] 484020004084 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 484020004085 active site 484020004086 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 484020004087 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 484020004088 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 484020004089 active site 484020004090 Zn binding site [ion binding]; other site 484020004091 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 484020004092 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 484020004093 dimer interface [polypeptide binding]; other site 484020004094 ssDNA binding site [nucleotide binding]; other site 484020004095 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484020004096 prolyl-tRNA synthetase; Provisional; Region: PRK09194 484020004097 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 484020004098 dimer interface [polypeptide binding]; other site 484020004099 motif 1; other site 484020004100 active site 484020004101 motif 2; other site 484020004102 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 484020004103 putative deacylase active site [active] 484020004104 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484020004105 active site 484020004106 motif 3; other site 484020004107 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 484020004108 anticodon binding site; other site 484020004109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020004110 PIF1-like helicase; Region: PIF1; pfam05970 484020004111 Walker A motif; other site 484020004112 ATP binding site [chemical binding]; other site 484020004113 Walker B motif; other site 484020004114 arginine finger; other site 484020004115 Helicase; Region: Herpes_Helicase; pfam02689 484020004116 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 484020004117 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 484020004118 active site 484020004119 motif I; other site 484020004120 motif II; other site 484020004121 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020004122 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 484020004123 catalytic site [active] 484020004124 putative active site [active] 484020004125 putative substrate binding site [chemical binding]; other site 484020004126 dimer interface [polypeptide binding]; other site 484020004127 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484020004128 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020004129 ATP binding site [chemical binding]; other site 484020004130 G-X-G motif; other site 484020004131 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 484020004132 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 484020004133 active site 484020004134 catalytic site [active] 484020004135 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 484020004136 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 484020004137 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484020004138 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 484020004139 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 484020004140 active site 484020004141 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 484020004142 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 484020004143 Mg++ binding site [ion binding]; other site 484020004144 putative catalytic motif [active] 484020004145 substrate binding site [chemical binding]; other site 484020004146 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 484020004147 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 484020004148 putative CoA binding site [chemical binding]; other site 484020004149 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 484020004150 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020004151 S-adenosylmethionine binding site [chemical binding]; other site 484020004152 peptide chain release factor 1; Validated; Region: prfA; PRK00591 484020004153 This domain is found in peptide chain release factors; Region: PCRF; smart00937 484020004154 RF-1 domain; Region: RF-1; pfam00472 484020004155 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 484020004156 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 484020004157 conserved cys residue [active] 484020004158 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 484020004159 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484020004160 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 484020004161 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 484020004162 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484020004163 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484020004164 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484020004165 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 484020004166 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 484020004167 S-adenosylmethionine binding site [chemical binding]; other site 484020004168 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 484020004169 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 484020004170 active site 484020004171 phosphate binding residues; other site 484020004172 catalytic residues [active] 484020004173 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 484020004174 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 484020004175 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 484020004176 ATP binding site [chemical binding]; other site 484020004177 putative Mg++ binding site [ion binding]; other site 484020004178 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 484020004179 nucleotide binding region [chemical binding]; other site 484020004180 ATP-binding site [chemical binding]; other site 484020004181 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 484020004182 EamA-like transporter family; Region: EamA; pfam00892 484020004183 EamA-like transporter family; Region: EamA; pfam00892 484020004184 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020004185 Walker B; other site 484020004186 D-loop; other site 484020004187 H-loop/switch region; other site 484020004188 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 484020004189 Transposase; Region: DDE_Tnp_ISL3; pfam01610 484020004190 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 484020004191 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 484020004192 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 484020004193 homodimer interface [polypeptide binding]; other site 484020004194 substrate-cofactor binding pocket; other site 484020004195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020004196 catalytic residue [active] 484020004197 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 484020004198 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 484020004199 nucleotide binding site [chemical binding]; other site 484020004200 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 484020004201 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020004202 Walker A/P-loop; other site 484020004203 ATP binding site [chemical binding]; other site 484020004204 Q-loop/lid; other site 484020004205 ABC transporter signature motif; other site 484020004206 Walker B; other site 484020004207 D-loop; other site 484020004208 H-loop/switch region; other site 484020004209 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484020004210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020004211 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 484020004212 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 484020004213 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 484020004214 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 484020004215 putative active site [active] 484020004216 Predicted membrane protein [Function unknown]; Region: COG3817 484020004217 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 484020004218 putative substrate binding pocket [chemical binding]; other site 484020004219 AC domain interface; other site 484020004220 catalytic triad [active] 484020004221 AB domain interface; other site 484020004222 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 484020004223 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 484020004224 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020004225 Walker A/P-loop; other site 484020004226 ATP binding site [chemical binding]; other site 484020004227 Q-loop/lid; other site 484020004228 ABC transporter signature motif; other site 484020004229 Walker B; other site 484020004230 D-loop; other site 484020004231 H-loop/switch region; other site 484020004232 ABC transporter; Region: ABC_tran_2; pfam12848 484020004233 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 484020004234 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 484020004235 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 484020004236 active site 484020004237 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 484020004238 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020004239 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 484020004240 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 484020004241 active site 484020004242 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 484020004243 catalytic triad [active] 484020004244 dimer interface [polypeptide binding]; other site 484020004245 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 484020004246 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 484020004247 homooctamer interface [polypeptide binding]; other site 484020004248 active site 484020004249 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 484020004250 catalytic center binding site [active] 484020004251 ATP binding site [chemical binding]; other site 484020004252 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 484020004253 catalytic center binding site [active] 484020004254 ATP binding site [chemical binding]; other site 484020004255 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 484020004256 dihydropteroate synthase; Region: DHPS; TIGR01496 484020004257 substrate binding pocket [chemical binding]; other site 484020004258 dimer interface [polypeptide binding]; other site 484020004259 inhibitor binding site; inhibition site 484020004260 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 484020004261 GTP cyclohydrolase I; Provisional; Region: PLN03044 484020004262 active site 484020004263 FtsH Extracellular; Region: FtsH_ext; pfam06480 484020004264 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 484020004265 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020004266 Walker A motif; other site 484020004267 ATP binding site [chemical binding]; other site 484020004268 Walker B motif; other site 484020004269 arginine finger; other site 484020004270 Peptidase family M41; Region: Peptidase_M41; pfam01434 484020004271 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 484020004272 active site 484020004273 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 484020004274 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 484020004275 Ligand Binding Site [chemical binding]; other site 484020004276 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 484020004277 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 484020004278 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 484020004279 Walker A/P-loop; other site 484020004280 ATP binding site [chemical binding]; other site 484020004281 Q-loop/lid; other site 484020004282 ABC transporter signature motif; other site 484020004283 Walker B; other site 484020004284 D-loop; other site 484020004285 H-loop/switch region; other site 484020004286 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 484020004287 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 484020004288 DXD motif; other site 484020004289 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484020004290 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 484020004291 Domain of unknown function DUF20; Region: UPF0118; pfam01594 484020004292 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 484020004293 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484020004294 active site 484020004295 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484020004296 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 484020004297 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 484020004298 dimer interface [polypeptide binding]; other site 484020004299 active site 484020004300 metal binding site [ion binding]; metal-binding site 484020004301 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 484020004302 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 484020004303 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 484020004304 NAD(P) binding site [chemical binding]; other site 484020004305 active site 484020004306 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 484020004307 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 484020004308 sequence-specific DNA binding site [nucleotide binding]; other site 484020004309 salt bridge; other site 484020004310 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 484020004311 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 484020004312 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 484020004313 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 484020004314 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 484020004315 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 484020004316 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 484020004317 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 484020004318 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020004319 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020004320 DNA binding site [nucleotide binding] 484020004321 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 484020004322 putative ligand binding site [chemical binding]; other site 484020004323 putative dimerization interface [polypeptide binding]; other site 484020004324 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 484020004325 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484020004326 dimer interface [polypeptide binding]; other site 484020004327 phosphorylation site [posttranslational modification] 484020004328 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020004329 ATP binding site [chemical binding]; other site 484020004330 Mg2+ binding site [ion binding]; other site 484020004331 G-X-G motif; other site 484020004332 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484020004333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020004334 active site 484020004335 phosphorylation site [posttranslational modification] 484020004336 intermolecular recognition site; other site 484020004337 dimerization interface [polypeptide binding]; other site 484020004338 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484020004339 DNA binding site [nucleotide binding] 484020004340 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 484020004341 transposase/IS protein; Provisional; Region: PRK09183 484020004342 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020004343 Walker A motif; other site 484020004344 ATP binding site [chemical binding]; other site 484020004345 Walker B motif; other site 484020004346 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 484020004347 Integrase core domain; Region: rve; pfam00665 484020004348 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020004349 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484020004350 Walker A/P-loop; other site 484020004351 ATP binding site [chemical binding]; other site 484020004352 Q-loop/lid; other site 484020004353 ABC transporter signature motif; other site 484020004354 Walker B; other site 484020004355 D-loop; other site 484020004356 H-loop/switch region; other site 484020004357 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 484020004358 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484020004359 FtsX-like permease family; Region: FtsX; pfam02687 484020004360 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484020004361 FtsX-like permease family; Region: FtsX; pfam02687 484020004362 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484020004363 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484020004364 Walker A/P-loop; other site 484020004365 ATP binding site [chemical binding]; other site 484020004366 Q-loop/lid; other site 484020004367 ABC transporter signature motif; other site 484020004368 Walker B; other site 484020004369 D-loop; other site 484020004370 H-loop/switch region; other site 484020004371 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 484020004372 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 484020004373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 484020004374 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 484020004375 Low molecular weight phosphatase family; Region: LMWPc; cd00115 484020004376 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 484020004377 active site 484020004378 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 484020004379 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 484020004380 folate binding site [chemical binding]; other site 484020004381 NADP+ binding site [chemical binding]; other site 484020004382 thymidylate synthase; Reviewed; Region: thyA; PRK01827 484020004383 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 484020004384 dimerization interface [polypeptide binding]; other site 484020004385 active site 484020004386 OsmC-like protein; Region: OsmC; pfam02566 484020004387 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484020004388 Ligand Binding Site [chemical binding]; other site 484020004389 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 484020004390 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 484020004391 NlpC/P60 family; Region: NLPC_P60; pfam00877 484020004392 Surface antigen [General function prediction only]; Region: COG3942 484020004393 CHAP domain; Region: CHAP; pfam05257 484020004394 phosphoserine aminotransferase; Provisional; Region: PRK03080 484020004395 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 484020004396 catalytic residue [active] 484020004397 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484020004398 dimer interface [polypeptide binding]; other site 484020004399 phosphorylation site [posttranslational modification] 484020004400 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020004401 ATP binding site [chemical binding]; other site 484020004402 Mg2+ binding site [ion binding]; other site 484020004403 G-X-G motif; other site 484020004404 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 484020004405 PhoU domain; Region: PhoU; pfam01895 484020004406 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484020004407 catalytic core [active] 484020004408 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 484020004409 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 484020004410 UbiA prenyltransferase family; Region: UbiA; pfam01040 484020004411 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 484020004412 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 484020004413 dimer interface [polypeptide binding]; other site 484020004414 putative anticodon binding site; other site 484020004415 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 484020004416 motif 1; other site 484020004417 dimer interface [polypeptide binding]; other site 484020004418 active site 484020004419 motif 2; other site 484020004420 motif 3; other site 484020004421 MFS transport protein AraJ; Provisional; Region: PRK10091 484020004422 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020004423 putative substrate translocation pore; other site 484020004424 Tetratricopeptide repeat; Region: TPR_12; pfam13424 484020004425 Tetratricopeptide repeat; Region: TPR_12; pfam13424 484020004426 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 484020004427 binding surface 484020004428 TPR motif; other site 484020004429 Tetratricopeptide repeat; Region: TPR_12; pfam13424 484020004430 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 484020004431 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 484020004432 PspC domain; Region: PspC; pfam04024 484020004433 Tetraspanin family; Region: Tetraspannin; pfam00335 484020004434 PspC domain; Region: PspC; pfam04024 484020004435 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 484020004436 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 484020004437 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 484020004438 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020004439 active site 484020004440 phosphorylation site [posttranslational modification] 484020004441 intermolecular recognition site; other site 484020004442 dimerization interface [polypeptide binding]; other site 484020004443 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 484020004444 DNA binding residues [nucleotide binding] 484020004445 dimerization interface [polypeptide binding]; other site 484020004446 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 484020004447 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 484020004448 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 484020004449 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 484020004450 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 484020004451 putative active site [active] 484020004452 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 484020004453 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 484020004454 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 484020004455 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 484020004456 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 484020004457 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 484020004458 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 484020004459 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 484020004460 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020004461 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020004462 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020004463 seryl-tRNA synthetase; Provisional; Region: PRK05431 484020004464 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 484020004465 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 484020004466 dimer interface [polypeptide binding]; other site 484020004467 active site 484020004468 motif 1; other site 484020004469 motif 2; other site 484020004470 motif 3; other site 484020004471 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 484020004472 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 484020004473 generic binding surface I; other site 484020004474 generic binding surface II; other site 484020004475 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 484020004476 putative active site [active] 484020004477 putative catalytic site [active] 484020004478 putative Mg binding site IVb [ion binding]; other site 484020004479 putative phosphate binding site [ion binding]; other site 484020004480 putative DNA binding site [nucleotide binding]; other site 484020004481 putative Mg binding site IVa [ion binding]; other site 484020004482 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 484020004483 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 484020004484 putative active site [active] 484020004485 putative metal binding site [ion binding]; other site 484020004486 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 484020004487 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 484020004488 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 484020004489 transcriptional antiterminator BglG; Provisional; Region: PRK09772 484020004490 CAT RNA binding domain; Region: CAT_RBD; smart01061 484020004491 PRD domain; Region: PRD; pfam00874 484020004492 PRD domain; Region: PRD; pfam00874 484020004493 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 484020004494 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 484020004495 active site turn [active] 484020004496 phosphorylation site [posttranslational modification] 484020004497 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 484020004498 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 484020004499 HPr interaction site; other site 484020004500 glycerol kinase (GK) interaction site [polypeptide binding]; other site 484020004501 active site 484020004502 phosphorylation site [posttranslational modification] 484020004503 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 484020004504 phosphoglucomutase; Validated; Region: PRK07564 484020004505 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 484020004506 active site 484020004507 substrate binding site [chemical binding]; other site 484020004508 metal binding site [ion binding]; metal-binding site 484020004509 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 484020004510 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484020004511 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 484020004512 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 484020004513 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020004514 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020004515 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 484020004516 RNA/DNA hybrid binding site [nucleotide binding]; other site 484020004517 active site 484020004518 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 484020004519 tetramer (dimer of dimers) interface [polypeptide binding]; other site 484020004520 active site 484020004521 dimer interface [polypeptide binding]; other site 484020004522 DNA repair protein RadA; Provisional; Region: PRK11823 484020004523 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 484020004524 Walker A motif; other site 484020004525 ATP binding site [chemical binding]; other site 484020004526 Walker B motif; other site 484020004527 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 484020004528 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 484020004529 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 484020004530 active site 484020004531 Riboflavin kinase; Region: Flavokinase; smart00904 484020004532 tRNA pseudouridine synthase B; Provisional; Region: PRK14122 484020004533 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 484020004534 RNA binding site [nucleotide binding]; other site 484020004535 active site 484020004536 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 484020004537 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 484020004538 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 484020004539 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 484020004540 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 484020004541 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 484020004542 G1 box; other site 484020004543 putative GEF interaction site [polypeptide binding]; other site 484020004544 GTP/Mg2+ binding site [chemical binding]; other site 484020004545 Switch I region; other site 484020004546 G2 box; other site 484020004547 G3 box; other site 484020004548 Switch II region; other site 484020004549 G4 box; other site 484020004550 G5 box; other site 484020004551 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 484020004552 Translation-initiation factor 2; Region: IF-2; pfam11987 484020004553 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 484020004554 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 484020004555 NusA N-terminal domain; Region: NusA_N; pfam08529 484020004556 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 484020004557 RNA binding site [nucleotide binding]; other site 484020004558 homodimer interface [polypeptide binding]; other site 484020004559 NusA-like KH domain; Region: KH_5; pfam13184 484020004560 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 484020004561 G-X-X-G motif; other site 484020004562 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 484020004563 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 484020004564 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 484020004565 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 484020004566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 484020004567 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 484020004568 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 484020004569 dimerization interface 3.5A [polypeptide binding]; other site 484020004570 active site 484020004571 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020004572 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 484020004573 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 484020004574 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 484020004575 active site 484020004576 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 484020004577 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 484020004578 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 484020004579 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 484020004580 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 484020004581 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 484020004582 alphaNTD homodimer interface [polypeptide binding]; other site 484020004583 alphaNTD - beta interaction site [polypeptide binding]; other site 484020004584 alphaNTD - beta' interaction site [polypeptide binding]; other site 484020004585 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 484020004586 30S ribosomal protein S11; Validated; Region: PRK05309 484020004587 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 484020004588 30S ribosomal protein S13; Region: bact_S13; TIGR03631 484020004589 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 484020004590 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 484020004591 rRNA binding site [nucleotide binding]; other site 484020004592 predicted 30S ribosome binding site; other site 484020004593 adenylate kinase; Reviewed; Region: adk; PRK00279 484020004594 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 484020004595 AMP-binding site [chemical binding]; other site 484020004596 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 484020004597 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 484020004598 SecY translocase; Region: SecY; pfam00344 484020004599 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 484020004600 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 484020004601 23S rRNA binding site [nucleotide binding]; other site 484020004602 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 484020004603 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 484020004604 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 484020004605 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 484020004606 5S rRNA interface [nucleotide binding]; other site 484020004607 23S rRNA interface [nucleotide binding]; other site 484020004608 L5 interface [polypeptide binding]; other site 484020004609 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 484020004610 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 484020004611 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 484020004612 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 484020004613 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 484020004614 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 484020004615 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 484020004616 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 484020004617 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 484020004618 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 484020004619 RNA binding site [nucleotide binding]; other site 484020004620 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 484020004621 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 484020004622 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 484020004623 23S rRNA interface [nucleotide binding]; other site 484020004624 putative translocon interaction site; other site 484020004625 signal recognition particle (SRP54) interaction site; other site 484020004626 L23 interface [polypeptide binding]; other site 484020004627 trigger factor interaction site; other site 484020004628 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 484020004629 23S rRNA interface [nucleotide binding]; other site 484020004630 5S rRNA interface [nucleotide binding]; other site 484020004631 putative antibiotic binding site [chemical binding]; other site 484020004632 L25 interface [polypeptide binding]; other site 484020004633 L27 interface [polypeptide binding]; other site 484020004634 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 484020004635 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 484020004636 G-X-X-G motif; other site 484020004637 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 484020004638 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 484020004639 putative translocon binding site; other site 484020004640 protein-rRNA interface [nucleotide binding]; other site 484020004641 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 484020004642 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 484020004643 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 484020004644 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 484020004645 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 484020004646 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 484020004647 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 484020004648 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 484020004649 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 484020004650 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 484020004651 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 484020004652 putative catalytic cysteine [active] 484020004653 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 484020004654 putative active site [active] 484020004655 metal binding site [ion binding]; metal-binding site 484020004656 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 484020004657 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 484020004658 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484020004659 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 484020004660 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 484020004661 pullulanase, type I; Region: pulA_typeI; TIGR02104 484020004662 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 484020004663 active site 484020004664 catalytic site [active] 484020004665 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 484020004666 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 484020004667 23S rRNA interface [nucleotide binding]; other site 484020004668 L3 interface [polypeptide binding]; other site 484020004669 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 484020004670 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 484020004671 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 484020004672 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 484020004673 putative active site [active] 484020004674 putative metal binding site [ion binding]; other site 484020004675 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 484020004676 active site 484020004677 DNA polymerase IV; Validated; Region: PRK02406 484020004678 DNA binding site [nucleotide binding] 484020004679 Protein of unknown function (DUF3812); Region: DUF3812; pfam12757 484020004680 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 484020004681 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020004682 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020004683 homodimer interface [polypeptide binding]; other site 484020004684 catalytic residue [active] 484020004685 Ferredoxin [Energy production and conversion]; Region: COG1146 484020004686 4Fe-4S binding domain; Region: Fer4; pfam00037 484020004687 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 484020004688 FAD binding domain; Region: FAD_binding_4; pfam01565 484020004689 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 484020004690 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 484020004691 MoxR-like ATPases [General function prediction only]; Region: COG0714 484020004692 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 484020004693 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 484020004694 oligomerisation interface [polypeptide binding]; other site 484020004695 mobile loop; other site 484020004696 roof hairpin; other site 484020004697 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 484020004698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 484020004699 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 484020004700 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 484020004701 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 484020004702 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 484020004703 Part of AAA domain; Region: AAA_19; pfam13245 484020004704 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 484020004705 phosphopeptide binding site; other site 484020004706 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 484020004707 peripheral dimer interface [polypeptide binding]; other site 484020004708 core dimer interface [polypeptide binding]; other site 484020004709 L10 interface [polypeptide binding]; other site 484020004710 L11 interface [polypeptide binding]; other site 484020004711 putative EF-Tu interaction site [polypeptide binding]; other site 484020004712 putative EF-G interaction site [polypeptide binding]; other site 484020004713 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 484020004714 23S rRNA interface [nucleotide binding]; other site 484020004715 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 484020004716 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 484020004717 active site 484020004718 catalytic triad [active] 484020004719 oxyanion hole [active] 484020004720 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 484020004721 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 484020004722 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 484020004723 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 484020004724 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 484020004725 Asp-box motif; other site 484020004726 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 484020004727 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 484020004728 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 484020004729 Walker A/P-loop; other site 484020004730 ATP binding site [chemical binding]; other site 484020004731 Q-loop/lid; other site 484020004732 ABC transporter signature motif; other site 484020004733 Walker B; other site 484020004734 D-loop; other site 484020004735 H-loop/switch region; other site 484020004736 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 484020004737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020004738 dimer interface [polypeptide binding]; other site 484020004739 conserved gate region; other site 484020004740 putative PBP binding loops; other site 484020004741 ABC-ATPase subunit interface; other site 484020004742 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 484020004743 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 484020004744 dimer interface [polypeptide binding]; other site 484020004745 conserved gate region; other site 484020004746 putative PBP binding loops; other site 484020004747 ABC-ATPase subunit interface; other site 484020004748 PBP superfamily domain; Region: PBP_like_2; cl17296 484020004749 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484020004750 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 484020004751 active site 484020004752 phosphorylation site [posttranslational modification] 484020004753 intermolecular recognition site; other site 484020004754 dimerization interface [polypeptide binding]; other site 484020004755 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484020004756 DNA binding site [nucleotide binding] 484020004757 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 484020004758 dimer interface [polypeptide binding]; other site 484020004759 phosphorylation site [posttranslational modification] 484020004760 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 484020004761 ATP binding site [chemical binding]; other site 484020004762 Mg2+ binding site [ion binding]; other site 484020004763 G-X-G motif; other site 484020004764 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 484020004765 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 484020004766 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 484020004767 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484020004768 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484020004769 dimerization interface [polypeptide binding]; other site 484020004770 putative DNA binding site [nucleotide binding]; other site 484020004771 putative Zn2+ binding site [ion binding]; other site 484020004772 H+ Antiporter protein; Region: 2A0121; TIGR00900 484020004773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020004774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 484020004775 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 484020004776 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 484020004777 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 484020004778 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 484020004779 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 484020004780 trimer interface [polypeptide binding]; other site 484020004781 active site 484020004782 G bulge; other site 484020004783 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 484020004784 chromosome segregation protein; Provisional; Region: PRK02224 484020004785 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 484020004786 putative substrate binding pocket [chemical binding]; other site 484020004787 AC domain interface; other site 484020004788 catalytic triad [active] 484020004789 AB domain interface; other site 484020004790 interchain disulfide; other site 484020004791 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 484020004792 substrate binding site; other site 484020004793 dimer interface; other site 484020004794 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 484020004795 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 484020004796 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 484020004797 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 484020004798 Peptidase family U32; Region: Peptidase_U32; pfam01136 484020004799 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 484020004800 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 484020004801 active site 484020004802 catalytic tetrad [active] 484020004803 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 484020004804 catalytic residues [active] 484020004805 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 484020004806 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 484020004807 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 484020004808 Class I ribonucleotide reductase; Region: RNR_I; cd01679 484020004809 active site 484020004810 dimer interface [polypeptide binding]; other site 484020004811 catalytic residues [active] 484020004812 effector binding site; other site 484020004813 R2 peptide binding site; other site 484020004814 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 484020004815 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 484020004816 dimer interface [polypeptide binding]; other site 484020004817 putative radical transfer pathway; other site 484020004818 diiron center [ion binding]; other site 484020004819 tyrosyl radical; other site 484020004820 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 484020004821 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 484020004822 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 484020004823 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020004824 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020004825 DNA binding site [nucleotide binding] 484020004826 domain linker motif; other site 484020004827 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 484020004828 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 484020004829 oligomer interface [polypeptide binding]; other site 484020004830 RNA binding site [nucleotide binding]; other site 484020004831 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 484020004832 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 484020004833 RNase E interface [polypeptide binding]; other site 484020004834 trimer interface [polypeptide binding]; other site 484020004835 active site 484020004836 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 484020004837 putative nucleic acid binding region [nucleotide binding]; other site 484020004838 G-X-X-G motif; other site 484020004839 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 484020004840 RNA binding site [nucleotide binding]; other site 484020004841 domain interface; other site 484020004842 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 484020004843 16S/18S rRNA binding site [nucleotide binding]; other site 484020004844 S13e-L30e interaction site [polypeptide binding]; other site 484020004845 25S rRNA binding site [nucleotide binding]; other site 484020004846 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 484020004847 potential protein location (hypothetical protein BBB_1611 [Bifidobacterium bifidum BGN4]) that overlaps RNA (tRNA-G) 484020004848 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 484020004849 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 484020004850 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 484020004851 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 484020004852 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 484020004853 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 484020004854 phosphate binding site [ion binding]; other site 484020004855 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 484020004856 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 484020004857 putative active site [active] 484020004858 putative catalytic site [active] 484020004859 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 484020004860 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 484020004861 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 484020004862 putative NAD(P) binding site [chemical binding]; other site 484020004863 active site 484020004864 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 484020004865 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 484020004866 active site 484020004867 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 484020004868 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 484020004869 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 484020004870 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 484020004871 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 484020004872 ATP-grasp domain; Region: ATP-grasp_4; cl17255 484020004873 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 484020004874 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 484020004875 carboxyltransferase (CT) interaction site; other site 484020004876 biotinylation site [posttranslational modification]; other site 484020004877 BioY family; Region: BioY; pfam02632 484020004878 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 484020004879 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 484020004880 Protein of unknown function (DUF935); Region: DUF935; pfam06074 484020004881 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 484020004882 hypothetical protein; Provisional; Region: PRK03298 484020004883 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 484020004884 gamma subunit interface [polypeptide binding]; other site 484020004885 epsilon subunit interface [polypeptide binding]; other site 484020004886 LBP interface [polypeptide binding]; other site 484020004887 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 484020004888 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 484020004889 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 484020004890 alpha subunit interaction interface [polypeptide binding]; other site 484020004891 Walker A motif; other site 484020004892 ATP binding site [chemical binding]; other site 484020004893 Walker B motif; other site 484020004894 inhibitor binding site; inhibition site 484020004895 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 484020004896 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 484020004897 core domain interface [polypeptide binding]; other site 484020004898 delta subunit interface [polypeptide binding]; other site 484020004899 epsilon subunit interface [polypeptide binding]; other site 484020004900 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 484020004901 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 484020004902 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 484020004903 beta subunit interaction interface [polypeptide binding]; other site 484020004904 Walker A motif; other site 484020004905 ATP binding site [chemical binding]; other site 484020004906 Walker B motif; other site 484020004907 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 484020004908 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 484020004909 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 484020004910 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 484020004911 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 484020004912 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 484020004913 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 484020004914 homoserine O-succinyltransferase; Provisional; Region: PRK05368 484020004915 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 484020004916 proposed active site lysine [active] 484020004917 conserved cys residue [active] 484020004918 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 484020004919 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 484020004920 active site 484020004921 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 484020004922 Phage-related protein [Function unknown]; Region: COG4695; cl01923 484020004923 Phage portal protein; Region: Phage_portal; pfam04860 484020004924 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 484020004925 LEA14-like dessication related protein [Defense mechanisms]; Region: COG5608 484020004926 Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124 484020004927 tape measure domain; Region: tape_meas_nterm; TIGR02675 484020004928 Phage-related protein [Function unknown]; Region: COG5412 484020004929 Holin family; Region: Phage_holin_4; pfam05105 484020004930 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 484020004931 amidase catalytic site [active] 484020004932 Zn binding residues [ion binding]; other site 484020004933 substrate binding site [chemical binding]; other site 484020004934 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 484020004935 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 484020004936 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 484020004937 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 484020004938 active site 484020004939 DNA binding site [nucleotide binding] 484020004940 Int/Topo IB signature motif; other site 484020004941 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 484020004942 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 484020004943 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 484020004944 active site 484020004945 homodimer interface [polypeptide binding]; other site 484020004946 catalytic site [active] 484020004947 acceptor binding site [chemical binding]; other site 484020004948 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 484020004949 dimer interface [polypeptide binding]; other site 484020004950 substrate binding site [chemical binding]; other site 484020004951 metal binding sites [ion binding]; metal-binding site 484020004952 Predicted membrane protein [Function unknown]; Region: COG1971 484020004953 Domain of unknown function DUF; Region: DUF204; pfam02659 484020004954 Domain of unknown function DUF; Region: DUF204; pfam02659 484020004955 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 484020004956 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 484020004957 DNA binding site [nucleotide binding] 484020004958 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 484020004959 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 484020004960 minor groove reading motif; other site 484020004961 helix-hairpin-helix signature motif; other site 484020004962 substrate binding pocket [chemical binding]; other site 484020004963 active site 484020004964 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 484020004965 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 484020004966 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 484020004967 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 484020004968 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484020004969 active site 484020004970 HIGH motif; other site 484020004971 nucleotide binding site [chemical binding]; other site 484020004972 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 484020004973 active site 484020004974 KMSKS motif; other site 484020004975 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 484020004976 tRNA binding surface [nucleotide binding]; other site 484020004977 anticodon binding site; other site 484020004978 chorismate mutase; Provisional; Region: PRK09239 484020004979 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484020004980 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 484020004981 putative DNA binding site [nucleotide binding]; other site 484020004982 putative Zn2+ binding site [ion binding]; other site 484020004983 AsnC family; Region: AsnC_trans_reg; pfam01037 484020004984 aspartate aminotransferase; Provisional; Region: PRK05764 484020004985 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 484020004986 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020004987 homodimer interface [polypeptide binding]; other site 484020004988 catalytic residue [active] 484020004989 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 484020004990 transcription termination factor Rho; Provisional; Region: PRK12608 484020004991 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 484020004992 RNA binding site [nucleotide binding]; other site 484020004993 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 484020004994 multimer interface [polypeptide binding]; other site 484020004995 Walker A motif; other site 484020004996 ATP binding site [chemical binding]; other site 484020004997 Walker B motif; other site 484020004998 hypothetical protein; Provisional; Region: PRK07208 484020004999 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484020005000 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 484020005001 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 484020005002 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 484020005003 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 484020005004 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 484020005005 GatB domain; Region: GatB_Yqey; pfam02637 484020005006 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 484020005007 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 484020005008 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 484020005009 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020005010 H-loop/switch region; other site 484020005011 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020005012 Walker A/P-loop; other site 484020005013 ATP binding site [chemical binding]; other site 484020005014 Q-loop/lid; other site 484020005015 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 484020005016 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 484020005017 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 484020005018 RmuC family; Region: RmuC; pfam02646 484020005019 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 484020005020 putative homodimer interface [polypeptide binding]; other site 484020005021 putative homotetramer interface [polypeptide binding]; other site 484020005022 putative allosteric switch controlling residues; other site 484020005023 putative metal binding site [ion binding]; other site 484020005024 putative homodimer-homodimer interface [polypeptide binding]; other site 484020005025 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 484020005026 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 484020005027 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484020005028 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020005029 active site 484020005030 motif I; other site 484020005031 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 484020005032 motif II; other site 484020005033 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 484020005034 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 484020005035 ABC1 family; Region: ABC1; cl17513 484020005036 Uncharacterized conserved protein [Function unknown]; Region: COG3937 484020005037 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 484020005038 catalytic triad [active] 484020005039 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 484020005040 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 484020005041 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 484020005042 replicative DNA helicase; Region: DnaB; TIGR00665 484020005043 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 484020005044 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 484020005045 Walker A motif; other site 484020005046 ATP binding site [chemical binding]; other site 484020005047 Walker B motif; other site 484020005048 DNA binding loops [nucleotide binding] 484020005049 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 484020005050 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 484020005051 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 484020005052 metal binding triad; other site 484020005053 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 484020005054 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484020005055 Zn2+ binding site [ion binding]; other site 484020005056 Mg2+ binding site [ion binding]; other site 484020005057 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 484020005058 Nitrogen regulatory protein P-II; Region: P-II; smart00938 484020005059 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 484020005060 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 484020005061 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 484020005062 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 484020005063 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 484020005064 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 484020005065 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 484020005066 active site 484020005067 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 484020005068 Peptidase family C69; Region: Peptidase_C69; pfam03577 484020005069 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 484020005070 Cobalt transport protein; Region: CbiQ; cl00463 484020005071 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484020005072 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484020005073 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 484020005074 Walker A/P-loop; other site 484020005075 ATP binding site [chemical binding]; other site 484020005076 Q-loop/lid; other site 484020005077 ABC transporter signature motif; other site 484020005078 Walker B; other site 484020005079 D-loop; other site 484020005080 H-loop/switch region; other site 484020005081 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 484020005082 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 484020005083 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020005084 Walker A/P-loop; other site 484020005085 ATP binding site [chemical binding]; other site 484020005086 Q-loop/lid; other site 484020005087 ABC transporter signature motif; other site 484020005088 Walker B; other site 484020005089 D-loop; other site 484020005090 H-loop/switch region; other site 484020005091 MarR family; Region: MarR_2; pfam12802 484020005092 Transcriptional regulators [Transcription]; Region: MarR; COG1846 484020005093 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 484020005094 Cna protein B-type domain; Region: Cna_B; pfam05738 484020005095 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 484020005096 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 484020005097 active site 484020005098 catalytic site [active] 484020005099 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020005100 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 484020005101 active site 484020005102 motif I; other site 484020005103 motif II; other site 484020005104 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020005105 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 484020005106 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 484020005107 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 484020005108 beta-galactosidase; Region: BGL; TIGR03356 484020005109 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 484020005110 methionine cluster; other site 484020005111 active site 484020005112 phosphorylation site [posttranslational modification] 484020005113 metal binding site [ion binding]; metal-binding site 484020005114 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 484020005115 active site 484020005116 P-loop; other site 484020005117 phosphorylation site [posttranslational modification] 484020005118 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 484020005119 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 484020005120 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 484020005121 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 484020005122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 484020005123 DNA-binding site [nucleotide binding]; DNA binding site 484020005124 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 484020005125 FMN-binding domain; Region: FMN_bind; pfam04205 484020005126 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 484020005127 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 484020005128 Walker A/P-loop; other site 484020005129 ATP binding site [chemical binding]; other site 484020005130 Q-loop/lid; other site 484020005131 ABC transporter signature motif; other site 484020005132 Walker B; other site 484020005133 D-loop; other site 484020005134 H-loop/switch region; other site 484020005135 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 484020005136 FtsX-like permease family; Region: FtsX; pfam02687 484020005137 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484020005138 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 484020005139 FtsX-like permease family; Region: FtsX; pfam02687 484020005140 Predicted membrane protein [Function unknown]; Region: COG4393 484020005141 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 484020005142 Fe2+ transport protein; Region: Iron_transport; pfam10634 484020005143 Iron permease FTR1 family; Region: FTR1; cl00475 484020005144 ApbE family; Region: ApbE; pfam02424 484020005145 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 484020005146 putative Zn2+ binding site [ion binding]; other site 484020005147 putative DNA binding site [nucleotide binding]; other site 484020005148 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 484020005149 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 484020005150 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 484020005151 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 484020005152 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 484020005153 dimerization domain swap beta strand [polypeptide binding]; other site 484020005154 regulatory protein interface [polypeptide binding]; other site 484020005155 active site 484020005156 regulatory phosphorylation site [posttranslational modification]; other site 484020005157 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020005158 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020005159 DNA binding site [nucleotide binding] 484020005160 domain linker motif; other site 484020005161 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484020005162 dimerization interface [polypeptide binding]; other site 484020005163 ligand binding site [chemical binding]; other site 484020005164 DNA polymerase III subunit delta'; Validated; Region: PRK07940 484020005165 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020005166 Walker A motif; other site 484020005167 ATP binding site [chemical binding]; other site 484020005168 Walker B motif; other site 484020005169 arginine finger; other site 484020005170 thymidylate kinase; Validated; Region: tmk; PRK00698 484020005171 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 484020005172 TMP-binding site; other site 484020005173 ATP-binding site [chemical binding]; other site 484020005174 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 484020005175 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 484020005176 active site 484020005177 interdomain interaction site; other site 484020005178 putative metal-binding site [ion binding]; other site 484020005179 nucleotide binding site [chemical binding]; other site 484020005180 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 484020005181 domain I; other site 484020005182 phosphate binding site [ion binding]; other site 484020005183 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 484020005184 domain II; other site 484020005185 domain III; other site 484020005186 nucleotide binding site [chemical binding]; other site 484020005187 DNA binding groove [nucleotide binding] 484020005188 catalytic site [active] 484020005189 domain IV; other site 484020005190 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 484020005191 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 484020005192 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 484020005193 active site 484020005194 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 484020005195 putative active site [active] 484020005196 catalytic triad [active] 484020005197 PA domain; Region: PA; pfam02225 484020005198 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 484020005199 Haemolysin-III related; Region: HlyIII; pfam03006 484020005200 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 484020005201 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 484020005202 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 484020005203 UDP-galactopyranose mutase; Region: GLF; pfam03275 484020005204 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 484020005205 Transglycosylase; Region: Transgly; pfam00912 484020005206 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 484020005207 2-isopropylmalate synthase; Validated; Region: PRK03739 484020005208 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 484020005209 active site 484020005210 catalytic residues [active] 484020005211 metal binding site [ion binding]; metal-binding site 484020005212 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 484020005213 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 484020005214 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 484020005215 metal binding site [ion binding]; metal-binding site 484020005216 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 484020005217 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 484020005218 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 484020005219 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 484020005220 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 484020005221 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 484020005222 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 484020005223 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 484020005224 putative allosteric regulatory site; other site 484020005225 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 484020005226 aspartate kinase; Reviewed; Region: PRK06635 484020005227 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 484020005228 putative catalytic residues [active] 484020005229 putative nucleotide binding site [chemical binding]; other site 484020005230 putative aspartate binding site [chemical binding]; other site 484020005231 recombination protein RecR; Reviewed; Region: recR; PRK00076 484020005232 RecR protein; Region: RecR; pfam02132 484020005233 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 484020005234 putative active site [active] 484020005235 putative metal-binding site [ion binding]; other site 484020005236 tetramer interface [polypeptide binding]; other site 484020005237 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 484020005238 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 484020005239 Walker A motif; other site 484020005240 ATP binding site [chemical binding]; other site 484020005241 Walker B motif; other site 484020005242 arginine finger; other site 484020005243 diacylglycerol kinase; Reviewed; Region: PRK11914 484020005244 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 484020005245 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 484020005246 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 484020005247 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 484020005248 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 484020005249 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 484020005250 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 484020005251 Walker A motif; other site 484020005252 ATP binding site [chemical binding]; other site 484020005253 Walker B motif; other site 484020005254 AAA domain; Region: AAA_31; pfam13614 484020005255 polyphosphate kinase; Provisional; Region: PRK05443 484020005256 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 484020005257 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 484020005258 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 484020005259 putative domain interface [polypeptide binding]; other site 484020005260 putative active site [active] 484020005261 catalytic site [active] 484020005262 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 484020005263 putative domain interface [polypeptide binding]; other site 484020005264 putative active site [active] 484020005265 catalytic site [active] 484020005266 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 484020005267 active site 484020005268 Ap6A binding site [chemical binding]; other site 484020005269 nudix motif; other site 484020005270 metal binding site [ion binding]; metal-binding site 484020005271 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 484020005272 catalytic core [active] 484020005273 PDGLE domain; Region: PDGLE; cl07986 484020005274 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 484020005275 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 484020005276 Probable Catalytic site; other site 484020005277 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 484020005278 thiS-thiF/thiG interaction site; other site 484020005279 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 484020005280 ThiS interaction site; other site 484020005281 putative active site [active] 484020005282 tetramer interface [polypeptide binding]; other site 484020005283 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 484020005284 active site 484020005285 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 484020005286 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 484020005287 FtsX-like permease family; Region: FtsX; pfam02687 484020005288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 484020005289 ATP binding site [chemical binding]; other site 484020005290 ABC transporter; Region: ABC_tran; pfam00005 484020005291 Q-loop/lid; other site 484020005292 ABC transporter signature motif; other site 484020005293 Walker B; other site 484020005294 D-loop; other site 484020005295 H-loop/switch region; other site 484020005296 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 484020005297 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 484020005298 putative active site [active] 484020005299 putative dimer interface [polypeptide binding]; other site 484020005300 K+ potassium transporter; Region: K_trans; pfam02705 484020005301 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 484020005302 active site 484020005303 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020005304 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484020005305 MFS/sugar transport protein; Region: MFS_2; pfam13347 484020005306 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 484020005307 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 484020005308 active site 484020005309 HIGH motif; other site 484020005310 KMSKS motif; other site 484020005311 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 484020005312 tRNA binding surface [nucleotide binding]; other site 484020005313 anticodon binding site; other site 484020005314 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 484020005315 Predicted methyltransferases [General function prediction only]; Region: COG0313 484020005316 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 484020005317 putative SAM binding site [chemical binding]; other site 484020005318 putative homodimer interface [polypeptide binding]; other site 484020005319 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 484020005320 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 484020005321 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 484020005322 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 484020005323 motif II; other site 484020005324 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 484020005325 catalytic site [active] 484020005326 BNR repeat-like domain; Region: BNR_2; pfam13088 484020005327 Asp-box motif; other site 484020005328 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 484020005329 active site 484020005330 catalytic triad [active] 484020005331 oxyanion hole [active] 484020005332 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 484020005333 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 484020005334 catalytic site [active] 484020005335 Asp-box motif; other site 484020005336 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 484020005337 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 484020005338 DNA binding residues [nucleotide binding] 484020005339 putative dimer interface [polypeptide binding]; other site 484020005340 chaperone protein DnaJ; Provisional; Region: PRK14299 484020005341 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 484020005342 HSP70 interaction site [polypeptide binding]; other site 484020005343 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 484020005344 substrate binding site [polypeptide binding]; other site 484020005345 dimer interface [polypeptide binding]; other site 484020005346 GrpE; Region: GrpE; pfam01025 484020005347 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 484020005348 dimer interface [polypeptide binding]; other site 484020005349 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 484020005350 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 484020005351 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 484020005352 nucleotide binding site [chemical binding]; other site 484020005353 NEF interaction site [polypeptide binding]; other site 484020005354 SBD interface [polypeptide binding]; other site 484020005355 alkaline phosphatase; Provisional; Region: PRK10518 484020005356 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 484020005357 active site 484020005358 dimer interface [polypeptide binding]; other site 484020005359 Transcriptional regulators [Transcription]; Region: PurR; COG1609 484020005360 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 484020005361 DNA binding site [nucleotide binding] 484020005362 domain linker motif; other site 484020005363 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 484020005364 ligand binding site [chemical binding]; other site 484020005365 dimerization interface [polypeptide binding]; other site 484020005366 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 484020005367 catalytic core [active] 484020005368 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 484020005369 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 484020005370 dimer interface [polypeptide binding]; other site 484020005371 FMN binding site [chemical binding]; other site 484020005372 NADPH bind site [chemical binding]; other site 484020005373 Phosphotransferase enzyme family; Region: APH; pfam01636 484020005374 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 484020005375 active site 484020005376 ATP binding site [chemical binding]; other site 484020005377 antibiotic binding site [chemical binding]; other site 484020005378 NAD-dependent deacetylase; Provisional; Region: PRK00481 484020005379 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 484020005380 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 484020005381 tetramer interface [polypeptide binding]; other site 484020005382 threonine dehydratase; Provisional; Region: PRK08198 484020005383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 484020005384 catalytic residue [active] 484020005385 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 484020005386 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 484020005387 nucleoside/Zn binding site; other site 484020005388 dimer interface [polypeptide binding]; other site 484020005389 catalytic motif [active] 484020005390 Predicted esterase [General function prediction only]; Region: COG0400 484020005391 Serine hydrolase (FSH1); Region: FSH1; pfam03959 484020005392 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 484020005393 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 484020005394 trimer interface [polypeptide binding]; other site 484020005395 active site 484020005396 Melibiase; Region: Melibiase; pfam02065 484020005397 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 484020005398 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 484020005399 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 484020005400 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 484020005401 Soluble P-type ATPase [General function prediction only]; Region: COG4087 484020005402 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 484020005403 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 484020005404 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 484020005405 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 484020005406 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 484020005407 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 484020005408 active site 484020005409 catalytic site [active] 484020005410 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 484020005411 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 484020005412 Helix-turn-helix domain; Region: HTH_38; pfam13936 484020005413 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 484020005414 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 484020005415 Walker A/P-loop; other site 484020005416 ATP binding site [chemical binding]; other site 484020005417 Q-loop/lid; other site 484020005418 ABC transporter signature motif; other site 484020005419 Walker B; other site 484020005420 D-loop; other site 484020005421 H-loop/switch region; other site 484020005422 TOBE domain; Region: TOBE_2; pfam08402 484020005423 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 484020005424 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 484020005425 Catalytic domain of Protein Kinases; Region: PKc; cd00180 484020005426 active site 484020005427 ATP binding site [chemical binding]; other site 484020005428 substrate binding site [chemical binding]; other site 484020005429 activation loop (A-loop); other site 484020005430 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 484020005431 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 484020005432 catalytic residues [active] 484020005433 Domain of unknown function (DUF348); Region: DUF348; pfam03990 484020005434 Domain of unknown function (DUF348); Region: DUF348; pfam03990 484020005435 G5 domain; Region: G5; pfam07501 484020005436 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 484020005437 N-acetyl-D-glucosamine binding site [chemical binding]; other site 484020005438 catalytic residue [active] 484020005439 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 484020005440 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 484020005441 S-adenosylmethionine binding site [chemical binding]; other site 484020005442 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 484020005443 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 484020005444 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 484020005445 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 484020005446 active site 484020005447 NTP binding site [chemical binding]; other site 484020005448 metal binding triad [ion binding]; metal-binding site 484020005449 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 484020005450 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 484020005451 Zn2+ binding site [ion binding]; other site 484020005452 Mg2+ binding site [ion binding]; other site 484020005453 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 484020005454 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 484020005455 active site 484020005456 Ap6A binding site [chemical binding]; other site 484020005457 nudix motif; other site 484020005458 metal binding site [ion binding]; metal-binding site 484020005459 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 484020005460 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 484020005461 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 484020005462 thioredoxin reductase; Provisional; Region: PRK10262 484020005463 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 484020005464 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 484020005465 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 484020005466 ParB-like nuclease domain; Region: ParBc; pfam02195 484020005467 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 484020005468 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484020005469 P-loop; other site 484020005470 Magnesium ion binding site [ion binding]; other site 484020005471 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 484020005472 Magnesium ion binding site [ion binding]; other site 484020005473 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 484020005474 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 484020005475 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 484020005476 G-X-X-G motif; other site 484020005477 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 484020005478 RxxxH motif; other site 484020005479 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 484020005480 Ribonuclease P; Region: Ribonuclease_P; pfam00825 484020005481 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399