-- dump date 20140619_002337 -- class Genbank::misc_feature -- table misc_feature_note -- id note 702459000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 702459000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459000003 Walker A motif; other site 702459000004 ATP binding site [chemical binding]; other site 702459000005 Walker B motif; other site 702459000006 arginine finger; other site 702459000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 702459000008 DnaA box-binding interface [nucleotide binding]; other site 702459000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 702459000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 702459000011 putative DNA binding surface [nucleotide binding]; other site 702459000012 dimer interface [polypeptide binding]; other site 702459000013 beta-clamp/clamp loader binding surface; other site 702459000014 beta-clamp/translesion DNA polymerase binding surface; other site 702459000015 recombination protein F; Reviewed; Region: recF; PRK00064 702459000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459000017 Walker A/P-loop; other site 702459000018 ATP binding site [chemical binding]; other site 702459000019 Q-loop/lid; other site 702459000020 ABC transporter signature motif; other site 702459000021 Walker B; other site 702459000022 D-loop; other site 702459000023 H-loop/switch region; other site 702459000024 Protein of unknown function (DUF721); Region: DUF721; pfam05258 702459000025 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 702459000026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459000027 ATP binding site [chemical binding]; other site 702459000028 Mg2+ binding site [ion binding]; other site 702459000029 G-X-G motif; other site 702459000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 702459000031 anchoring element; other site 702459000032 dimer interface [polypeptide binding]; other site 702459000033 ATP binding site [chemical binding]; other site 702459000034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 702459000035 active site 702459000036 metal binding site [ion binding]; metal-binding site 702459000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 702459000038 DNA gyrase subunit A; Validated; Region: PRK05560 702459000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 702459000040 CAP-like domain; other site 702459000041 active site 702459000042 primary dimer interface [polypeptide binding]; other site 702459000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 702459000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 702459000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 702459000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 702459000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 702459000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 702459000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 702459000050 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 702459000051 active site 702459000052 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459000053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459000054 DNA binding site [nucleotide binding] 702459000055 domain linker motif; other site 702459000056 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 702459000057 dimerization interface [polypeptide binding]; other site 702459000058 ligand binding site [chemical binding]; other site 702459000059 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 702459000060 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 702459000061 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 702459000062 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459000063 S-adenosylmethionine binding site [chemical binding]; other site 702459000064 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 702459000065 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 702459000066 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 702459000067 Double zinc ribbon; Region: DZR; pfam12773 702459000068 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 702459000069 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 702459000070 active site 702459000071 DNA binding site [nucleotide binding] 702459000072 Int/Topo IB signature motif; other site 702459000073 glutamate dehydrogenase; Provisional; Region: PRK09414 702459000074 Glu/Leu/Phe/Val dehydrogenase, dimerization domain; Region: ELFV_dehydrog_N; pfam02812 702459000075 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 702459000076 NAD(P) binding site [chemical binding]; other site 702459000077 Transcriptional regulators [Transcription]; Region: FadR; COG2186 702459000078 FCD domain; Region: FCD; pfam07729 702459000079 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 702459000080 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 702459000081 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 702459000082 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 702459000083 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 702459000084 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 702459000085 Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887 702459000086 DEC-1 protein, N-terminal region; Region: DEC-1_N; pfam04625 702459000087 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 702459000088 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 702459000089 putative active site [active] 702459000090 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459000091 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459000092 DNA binding site [nucleotide binding] 702459000093 domain linker motif; other site 702459000094 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 702459000095 dimerization interface [polypeptide binding]; other site 702459000096 ligand binding site [chemical binding]; other site 702459000097 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 702459000098 active site 702459000099 phosphorylation site [posttranslational modification] 702459000100 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 702459000101 active site 702459000102 P-loop; other site 702459000103 phosphorylation site [posttranslational modification] 702459000104 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 702459000105 Protein of unknown function DUF45; Region: DUF45; pfam01863 702459000106 Ferritin-like domain; Region: Ferritin; pfam00210 702459000107 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 702459000108 dimerization interface [polypeptide binding]; other site 702459000109 DPS ferroxidase diiron center [ion binding]; other site 702459000110 ion pore; other site 702459000111 aromatic amino acid exporter; Provisional; Region: PRK11689 702459000112 EamA-like transporter family; Region: EamA; pfam00892 702459000113 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 702459000114 Domain of unknown function DUF21; Region: DUF21; pfam01595 702459000115 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 702459000116 Transporter associated domain; Region: CorC_HlyC; smart01091 702459000117 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459000118 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459000119 DNA binding site [nucleotide binding] 702459000120 domain linker motif; other site 702459000121 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 702459000122 dimerization interface [polypeptide binding]; other site 702459000123 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 702459000124 active site clefts [active] 702459000125 zinc binding site [ion binding]; other site 702459000126 dimer interface [polypeptide binding]; other site 702459000127 peroxiredoxin; Region: AhpC; TIGR03137 702459000128 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 702459000129 dimer interface [polypeptide binding]; other site 702459000130 decamer (pentamer of dimers) interface [polypeptide binding]; other site 702459000131 catalytic triad [active] 702459000132 peroxidatic and resolving cysteines [active] 702459000133 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 702459000134 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 702459000135 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 702459000136 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 702459000137 catalytic residue [active] 702459000138 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 702459000139 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 702459000140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459000141 putative substrate translocation pore; other site 702459000142 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 702459000143 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 702459000144 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 702459000145 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 702459000146 putative active site [active] 702459000147 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 702459000148 Tryptophanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: TrpS; COG0180 702459000149 active site 702459000150 nucleotide binding site [chemical binding]; other site 702459000151 HIGH motif; other site 702459000152 KMSKS motif; other site 702459000153 Protein of unknown function (DUF3073); Region: DUF3073; pfam11273 702459000154 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459000155 ATP binding site [chemical binding]; other site 702459000156 Mg2+ binding site [ion binding]; other site 702459000157 G-X-G motif; other site 702459000158 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 702459000159 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 702459000160 NAD binding site [chemical binding]; other site 702459000161 substrate binding site [chemical binding]; other site 702459000162 homodimer interface [polypeptide binding]; other site 702459000163 active site 702459000164 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 702459000165 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 702459000166 active site 702459000167 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 702459000168 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 702459000169 putative sugar binding sites [chemical binding]; other site 702459000170 Q-X-W motif; other site 702459000171 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 702459000172 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 702459000173 putative sugar binding sites [chemical binding]; other site 702459000174 Q-X-W motif; other site 702459000175 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 702459000176 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 702459000177 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 702459000178 putative sugar binding sites [chemical binding]; other site 702459000179 Q-X-W motif; other site 702459000180 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 702459000181 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 702459000182 Ligand binding site; other site 702459000183 Putative Catalytic site; other site 702459000184 DXD motif; other site 702459000185 HTH-like domain; Region: HTH_21; pfam13276 702459000186 Integrase core domain; Region: rve; pfam00665 702459000187 Integrase core domain; Region: rve_3; pfam13683 702459000188 Transposase; Region: HTH_Tnp_1; cl17663 702459000189 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 702459000190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459000191 Walker A motif; other site 702459000192 ATP binding site [chemical binding]; other site 702459000193 Walker B motif; other site 702459000194 arginine finger; other site 702459000195 Winged helix-turn helix; Region: HTH_29; pfam13551 702459000196 Helix-turn-helix domain; Region: HTH_38; pfam13936 702459000197 DNA-binding interface [nucleotide binding]; DNA binding site 702459000198 Integrase core domain; Region: rve; pfam00665 702459000199 Integrase core domain; Region: rve_2; pfam13333 702459000200 Integrase core domain; Region: rve_2; pfam13333 702459000201 Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264 702459000202 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 702459000203 Protein of unknown function (DUF2987); Region: DUF2987; pfam11205 702459000204 Rhamnan synthesis protein F; Region: RgpF; pfam05045 702459000205 Acyltransferase family; Region: Acyl_transf_3; pfam01757 702459000206 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 702459000207 extended (e) SDRs; Region: SDR_e; cd08946 702459000208 NAD(P) binding site [chemical binding]; other site 702459000209 active site 702459000210 substrate binding site [chemical binding]; other site 702459000211 Transposase; Region: HTH_Tnp_1; cl17663 702459000212 Helix-turn-helix domain; Region: HTH_28; pfam13518 702459000213 potential frameshift: common BLAST hit: gi|189440519|ref|YP_001955600.1| Transposase 702459000214 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 702459000215 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 702459000216 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 702459000217 Integrase core domain; Region: rve; pfam00665 702459000218 Helix-turn-helix domain of Hin and related proteins; Region: HTH_Hin_like; cl17393 702459000219 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 702459000220 DNA-binding interface [nucleotide binding]; DNA binding site 702459000221 Integrase core domain; Region: rve; pfam00665 702459000222 transposase/IS protein; Provisional; Region: PRK09183 702459000223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459000224 Walker A motif; other site 702459000225 ATP binding site [chemical binding]; other site 702459000226 Walker B motif; other site 702459000227 transposase; Provisional; Region: PRK06526 702459000228 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459000229 Walker A motif; other site 702459000230 ATP binding site [chemical binding]; other site 702459000231 Walker B motif; other site 702459000232 Integrase core domain; Region: rve; pfam00665 702459000233 Integrase core domain; Region: rve_2; pfam13333 702459000234 putative glycosyl transferase; Provisional; Region: PRK10073 702459000235 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 702459000236 active site 702459000237 putative transposase OrfB; Reviewed; Region: PHA02517 702459000238 Integrase core domain; Region: rve; pfam00665 702459000239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 702459000240 Transposase; Region: DDE_Tnp_ISL3; pfam01610 702459000241 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 702459000242 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 702459000243 substrate binding site; other site 702459000244 tetramer interface; other site 702459000245 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 702459000246 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 702459000247 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 702459000248 NADP binding site [chemical binding]; other site 702459000249 active site 702459000250 putative substrate binding site [chemical binding]; other site 702459000251 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 702459000252 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 702459000253 NAD binding site [chemical binding]; other site 702459000254 substrate binding site [chemical binding]; other site 702459000255 homodimer interface [polypeptide binding]; other site 702459000256 active site 702459000257 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 702459000258 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 702459000259 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 702459000260 Walker A/P-loop; other site 702459000261 ATP binding site [chemical binding]; other site 702459000262 Q-loop/lid; other site 702459000263 ABC transporter signature motif; other site 702459000264 Walker B; other site 702459000265 D-loop; other site 702459000266 H-loop/switch region; other site 702459000267 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cl15685 702459000268 potential frameshift: common BLAST hit: gi|310287329|ref|YP_003938587.1| Transposase 702459000269 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 702459000270 Helix-turn-helix domain; Region: HTH_38; pfam13936 702459000271 Integrase core domain; Region: rve; pfam00665 702459000272 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 702459000273 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 702459000274 AAA domain; Region: AAA_14; pfam13173 702459000275 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 702459000276 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 702459000277 Major Facilitator Superfamily; Region: MFS_1; pfam07690 702459000278 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459000279 putative substrate translocation pore; other site 702459000280 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 702459000281 FOG: CBS domain [General function prediction only]; Region: COG0517 702459000282 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 702459000283 Integrase core domain; Region: rve_3; cl15866 702459000284 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459000285 Walker A motif; other site 702459000286 ATP binding site [chemical binding]; other site 702459000287 Walker B motif; other site 702459000288 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 702459000289 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 702459000290 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 702459000291 homodimer interface [polypeptide binding]; other site 702459000292 active site pocket [active] 702459000293 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 702459000294 Integrase core domain; Region: rve; pfam00665 702459000295 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 702459000296 putative septation inhibitor protein; Reviewed; Region: PRK02251 702459000297 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 702459000298 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 702459000299 active site 702459000300 catalytic site [active] 702459000301 YwiC-like protein; Region: YwiC; pfam14256 702459000302 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 702459000303 Glutamine amidotransferase class-I; Region: GATase; pfam00117 702459000304 glutamine binding [chemical binding]; other site 702459000305 catalytic triad [active] 702459000306 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 702459000307 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 702459000308 active site 702459000309 ATP binding site [chemical binding]; other site 702459000310 substrate binding site [chemical binding]; other site 702459000311 activation loop (A-loop); other site 702459000312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 702459000313 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 702459000314 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 702459000315 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 702459000316 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 702459000317 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 702459000318 Catalytic domain of Protein Kinases; Region: PKc; cd00180 702459000319 active site 702459000320 ATP binding site [chemical binding]; other site 702459000321 substrate binding site [chemical binding]; other site 702459000322 activation loop (A-loop); other site 702459000323 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 702459000324 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 702459000325 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 702459000326 active site 702459000327 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 702459000328 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 702459000329 phosphopeptide binding site; other site 702459000330 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 702459000331 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 702459000332 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 702459000333 phosphopeptide binding site; other site 702459000334 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 702459000335 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 702459000336 Predicted membrane protein [Function unknown]; Region: COG1511 702459000337 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 702459000338 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 702459000339 Predicted membrane protein [Function unknown]; Region: COG1511 702459000340 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; cl19580 702459000341 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 702459000342 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 702459000343 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 702459000344 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 702459000345 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 702459000346 EamA-like transporter family; Region: EamA; pfam00892 702459000347 EamA-like transporter family; Region: EamA; pfam00892 702459000348 Protein of unknown function (DUF420); Region: DUF420; cl00989 702459000349 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 702459000350 methionine sulfoxide reductase B; Provisional; Region: PRK00222 702459000351 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 702459000352 PLD-like domain; Region: PLDc_2; pfam13091 702459000353 putative active site [active] 702459000354 catalytic site [active] 702459000355 DEAD-like helicases superfamily; Region: DEXDc; smart00487 702459000356 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459000357 ATP binding site [chemical binding]; other site 702459000358 putative Mg++ binding site [ion binding]; other site 702459000359 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459000360 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 702459000361 nucleotide binding region [chemical binding]; other site 702459000362 ATP-binding site [chemical binding]; other site 702459000363 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 702459000364 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 702459000365 active site 702459000366 8-oxo-dGMP binding site [chemical binding]; other site 702459000367 nudix motif; other site 702459000368 metal binding site [ion binding]; metal-binding site 702459000369 DivIVA domain; Region: DivI1A_domain; TIGR03544 702459000370 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 702459000371 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 702459000372 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 702459000373 Putative lysophospholipase; Region: Hydrolase_4; cl19140 702459000374 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 702459000375 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 702459000376 Coenzyme A binding pocket [chemical binding]; other site 702459000377 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 702459000378 Queuine tRNA-ribosyltransferase; Region: TGT; cl19224 702459000379 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 702459000380 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 702459000381 PDZ domain of trypsin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 702459000382 protein binding site [polypeptide binding]; other site 702459000383 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 702459000384 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 702459000385 Soluble P-type ATPase [General function prediction only]; Region: COG4087 702459000386 ferredoxin-NADP+ reductase; Region: PLN02852 702459000387 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 702459000388 heat shock protein HtpX; Provisional; Region: PRK03072 702459000389 heat shock protein HtpX; Provisional; Region: PRK01345 702459000390 Divergent AAA domain; Region: AAA_4; pfam04326 702459000391 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 702459000392 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 702459000393 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 702459000394 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 702459000395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 702459000396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459000397 non-specific DNA binding site [nucleotide binding]; other site 702459000398 salt bridge; other site 702459000399 sequence-specific DNA binding site [nucleotide binding]; other site 702459000400 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 702459000401 NodB motif; other site 702459000402 active site 702459000403 catalytic site [active] 702459000404 metal binding site [ion binding]; metal-binding site 702459000405 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 702459000406 active site 702459000407 intersubunit interface [polypeptide binding]; other site 702459000408 zinc binding site [ion binding]; other site 702459000409 Na+ binding site [ion binding]; other site 702459000410 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 702459000411 GDP-binding site [chemical binding]; other site 702459000412 ACT binding site; other site 702459000413 IMP binding site; other site 702459000414 CrcB-like protein; Region: CRCB; pfam02537 702459000415 CrcB-like protein; Region: CRCB; cl09114 702459000416 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459000417 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459000418 DNA binding site [nucleotide binding] 702459000419 domain linker motif; other site 702459000420 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 702459000421 dimerization interface [polypeptide binding]; other site 702459000422 ligand binding site [chemical binding]; other site 702459000423 sodium binding site [ion binding]; other site 702459000424 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 702459000425 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459000426 Major Facilitator Superfamily; Region: MFS_1; pfam07690 702459000427 putative substrate translocation pore; other site 702459000428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459000429 metabolite-proton symporter; Region: 2A0106; TIGR00883 702459000430 putative substrate translocation pore; other site 702459000431 ketol-acid reductoisomerase; Provisional; Region: PRK05479 702459000432 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 702459000433 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 702459000434 ketol-acid reductoisomerase; Provisional; Region: PRK05479 702459000435 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 702459000436 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 702459000437 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 702459000438 putative active site [active] 702459000439 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 702459000440 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 702459000441 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 702459000442 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 702459000443 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 702459000444 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 702459000445 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 702459000446 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 702459000447 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 702459000448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 702459000449 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 702459000450 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 702459000451 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 702459000452 Walker A/P-loop; other site 702459000453 ATP binding site [chemical binding]; other site 702459000454 Q-loop/lid; other site 702459000455 ABC transporter signature motif; other site 702459000456 Walker B; other site 702459000457 D-loop; other site 702459000458 H-loop/switch region; other site 702459000459 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 702459000460 Prefoldin subunit; Region: Prefoldin_2; pfam01920 702459000461 Domain of unknown function (DUF4515); Region: DUF4515; pfam14988 702459000462 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 702459000463 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459000464 FtsX-like permease family; Region: FtsX; pfam02687 702459000465 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 702459000466 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459000467 FtsX-like permease family; Region: FtsX; pfam02687 702459000468 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 702459000469 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459000470 active site 702459000471 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459000472 Q-loop/lid; other site 702459000473 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 702459000474 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 702459000475 catalytic triad [active] 702459000476 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 702459000477 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 702459000478 catalytic residues [active] 702459000479 Transposase; Region: DDE_Tnp_ISL3; pfam01610 702459000480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 702459000481 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 702459000482 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 702459000483 putative active site [active] 702459000484 putative metal binding site [ion binding]; other site 702459000485 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 702459000486 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 702459000487 HNH endonuclease; Region: HNH_2; pfam13391 702459000488 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 702459000489 Divergent AAA domain; Region: AAA_4; pfam04326 702459000490 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 702459000491 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459000492 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 702459000493 putative substrate translocation pore; other site 702459000494 Acyl transferase domain; Region: Acyl_transf_1; cl08282 702459000495 putative transposase OrfB; Reviewed; Region: PHA02517 702459000496 HTH-like domain; Region: HTH_21; pfam13276 702459000497 Integrase core domain; Region: rve; pfam00665 702459000498 Integrase core domain; Region: rve_3; pfam13683 702459000499 Transposase; Region: HTH_Tnp_1; cl17663 702459000500 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 702459000501 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 702459000502 WHG domain; Region: WHG; pfam13305 702459000503 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 702459000504 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 702459000505 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 702459000506 HsdM N-terminal domain; Region: HsdM_N; pfam12161 702459000507 Methyltransferase domain; Region: Methyltransf_26; pfam13659 702459000508 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 702459000509 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 702459000510 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 702459000511 Abi-like protein; Region: Abi_2; pfam07751 702459000512 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 702459000513 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 702459000514 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459000515 ATP binding site [chemical binding]; other site 702459000516 putative Mg++ binding site [ion binding]; other site 702459000517 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 702459000518 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 702459000519 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 702459000520 Transposon-encoded protein TnpV; Region: TnpV; pfam14198 702459000521 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 702459000522 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 702459000523 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 702459000524 active site 702459000525 catalytic residues [active] 702459000526 DNA binding site [nucleotide binding] 702459000527 Int/Topo IB signature motif; other site 702459000528 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 702459000529 active site 702459000530 catalytic tetrad [active] 702459000531 Protein of unknown function (DUF1778); Region: DUF1778; pfam08681 702459000532 Transcriptional regulators [Transcription]; Region: MarR; COG1846 702459000533 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 702459000534 putative Zn2+ binding site [ion binding]; other site 702459000535 putative DNA binding site [nucleotide binding]; other site 702459000536 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 702459000537 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 702459000538 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459000539 Walker A/P-loop; other site 702459000540 ATP binding site [chemical binding]; other site 702459000541 Q-loop/lid; other site 702459000542 ABC transporter signature motif; other site 702459000543 Walker B; other site 702459000544 D-loop; other site 702459000545 H-loop/switch region; other site 702459000546 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 702459000547 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 702459000548 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 702459000549 Walker A/P-loop; other site 702459000550 ATP binding site [chemical binding]; other site 702459000551 Q-loop/lid; other site 702459000552 ABC transporter signature motif; other site 702459000553 Walker B; other site 702459000554 D-loop; other site 702459000555 H-loop/switch region; other site 702459000556 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hyd_65N_2; pfam14498 702459000557 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 702459000558 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 702459000559 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 702459000560 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 702459000561 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 702459000562 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 702459000563 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 702459000564 substrate binding site [chemical binding]; other site 702459000565 Peptidase family C69; Region: Peptidase_C69; pfam03577 702459000566 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 702459000567 4-Oxalocrotonate Tautomerase: Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235 702459000568 GtrA-like protein; Region: GtrA; pfam04138 702459000569 Major Facilitator Superfamily; Region: MFS_1; pfam07690 702459000570 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 702459000571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459000572 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 702459000573 catalytic core [active] 702459000574 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 702459000575 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459000576 dimer interface [polypeptide binding]; other site 702459000577 conserved gate region; other site 702459000578 putative PBP binding loops; other site 702459000579 ABC-ATPase subunit interface; other site 702459000580 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 702459000581 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 702459000582 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 702459000583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459000584 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 702459000585 active site 702459000586 motif I; other site 702459000587 motif II; other site 702459000588 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 702459000589 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 702459000590 active site 702459000591 HIGH motif; other site 702459000592 KMSKS motif; other site 702459000593 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 702459000594 AAA domain; Region: AAA_14; pfam13173 702459000595 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 702459000596 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 702459000597 putative active site [active] 702459000598 putative metal binding site [ion binding]; other site 702459000599 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 702459000600 Transcriptional regulator [Transcription]; Region: IclR; COG1414 702459000601 Bacterial transcriptional regulator; Region: IclR; pfam01614 702459000602 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 702459000603 substrate binding site [chemical binding]; other site 702459000604 ligand binding site [chemical binding]; other site 702459000605 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 702459000606 substrate binding site [chemical binding]; other site 702459000607 SWIM zinc finger; Region: SWIM; pfam04434 702459000608 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 702459000609 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 702459000610 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459000611 ATP binding site [chemical binding]; other site 702459000612 putative Mg++ binding site [ion binding]; other site 702459000613 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459000614 nucleotide binding region [chemical binding]; other site 702459000615 ATP-binding site [chemical binding]; other site 702459000616 CAAX protease self-immunity; Region: Abi; pfam02517 702459000617 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 702459000618 active site 702459000619 FMN binding site [chemical binding]; other site 702459000620 substrate binding site [chemical binding]; other site 702459000621 EPSP synthase (3-phosphoshikimate 1-carboxyvinyltransferase); Region: EPSP_synthase; pfam00275 702459000622 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 702459000623 hinge; other site 702459000624 active site 702459000625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459000626 H+ Antiporter protein; Region: 2A0121; TIGR00900 702459000627 putative substrate translocation pore; other site 702459000628 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 702459000629 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 702459000630 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 702459000631 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 702459000632 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 702459000633 23S rRNA interface [nucleotide binding]; other site 702459000634 L7/L12 interface [polypeptide binding]; other site 702459000635 putative thiostrepton binding site; other site 702459000636 L25 interface [polypeptide binding]; other site 702459000637 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 702459000638 mRNA/rRNA interface [nucleotide binding]; other site 702459000639 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 702459000640 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 702459000641 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 702459000642 Tetratricopeptide repeat; Region: TPR_20; pfam14561 702459000643 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 702459000644 putative active site; other site 702459000645 putative metal binding residues [ion binding]; other site 702459000646 signature motif; other site 702459000647 putative triphosphate binding site [ion binding]; other site 702459000648 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459000649 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459000650 DNA binding site [nucleotide binding] 702459000651 domain linker motif; other site 702459000652 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 702459000653 potential frameshift: common BLAST hit: gi|296454945|ref|YP_003662089.1| mandelate racemase/muconate lactonizing enzyme C-terminal 702459000654 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 702459000655 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 702459000656 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 702459000657 substrate binding pocket [chemical binding]; other site 702459000658 classical (c) SDRs; Region: SDR_c; cd05233 702459000659 NAD(P) binding site [chemical binding]; other site 702459000660 active site 702459000661 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 702459000662 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 702459000663 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 702459000664 homotrimer interaction site [polypeptide binding]; other site 702459000665 putative active site [active] 702459000666 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 702459000667 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 702459000668 active site 702459000669 catalytic site [active] 702459000670 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 702459000671 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 702459000672 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 702459000673 active site 702459000674 HIGH motif; other site 702459000675 KMSK motif region; other site 702459000676 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 702459000677 tRNA binding surface [nucleotide binding]; other site 702459000678 anticodon binding site; other site 702459000679 diaminopimelate decarboxylase; Region: lysA; TIGR01048 702459000680 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 702459000681 active site 702459000682 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 702459000683 substrate binding site [chemical binding]; other site 702459000684 catalytic residues [active] 702459000685 dimer interface [polypeptide binding]; other site 702459000686 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 702459000687 HPr interaction site; other site 702459000688 glycerol kinase (GK) interaction site [polypeptide binding]; other site 702459000689 active site 702459000690 phosphorylation site [posttranslational modification] 702459000691 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 702459000692 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 702459000693 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 702459000694 active site turn [active] 702459000695 phosphorylation site [posttranslational modification] 702459000696 homoserine dehydrogenase; Provisional; Region: PRK06349 702459000697 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 702459000698 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 702459000699 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 702459000700 homoserine kinase; Provisional; Region: PRK01212 702459000701 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 702459000702 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 702459000703 active site 702459000704 dimer interface [polypeptide binding]; other site 702459000705 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 702459000706 nudix motif; other site 702459000707 histidinol dehydrogenase; Region: hisD; TIGR00069 702459000708 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 702459000709 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 702459000710 Walker A/P-loop; other site 702459000711 ATP binding site [chemical binding]; other site 702459000712 Q-loop/lid; other site 702459000713 ABC transporter signature motif; other site 702459000714 Walker B; other site 702459000715 D-loop; other site 702459000716 H-loop/switch region; other site 702459000717 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 702459000718 Predicted permeases [General function prediction only]; Region: COG0679 702459000719 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 702459000720 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 702459000721 metal binding site [ion binding]; metal-binding site 702459000722 putative dimer interface [polypeptide binding]; other site 702459000723 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 702459000724 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 702459000725 homodimer interface [polypeptide binding]; other site 702459000726 oligonucleotide binding site [chemical binding]; other site 702459000727 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 702459000728 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 702459000729 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 702459000730 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 702459000731 GTPase CgtA; Reviewed; Region: obgE; PRK12296 702459000732 GTP1/OBG; Region: GTP1_OBG; pfam01018 702459000733 Obg GTPase; Region: Obg; cd01898 702459000734 G1 box; other site 702459000735 GTP/Mg2+ binding site [chemical binding]; other site 702459000736 Switch I region; other site 702459000737 G2 box; other site 702459000738 G3 box; other site 702459000739 Switch II region; other site 702459000740 G4 box; other site 702459000741 G5 box; other site 702459000742 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 702459000743 gamma-glutamyl kinase; Provisional; Region: PRK05429 702459000744 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 702459000745 nucleotide binding site [chemical binding]; other site 702459000746 homotetrameric interface [polypeptide binding]; other site 702459000747 putative phosphate binding site [ion binding]; other site 702459000748 putative allosteric binding site; other site 702459000749 PUA domain; Region: PUA; pfam01472 702459000750 aspartate aminotransferase; Provisional; Region: PRK05764 702459000751 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459000752 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459000753 homodimer interface [polypeptide binding]; other site 702459000754 catalytic residue [active] 702459000755 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 702459000756 DNA packaging tegument protein UL25; Provisional; Region: PHA03248 702459000757 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 702459000758 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 702459000759 putative homodimer interface [polypeptide binding]; other site 702459000760 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 702459000761 heterodimer interface [polypeptide binding]; other site 702459000762 homodimer interface [polypeptide binding]; other site 702459000763 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 702459000764 putative acyl-acceptor binding pocket; other site 702459000765 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 702459000766 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 702459000767 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 702459000768 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 702459000769 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 702459000770 ATP-grasp domain; Region: ATP-grasp_4; cl17255 702459000771 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 702459000772 active site 702459000773 catalytic site [active] 702459000774 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 702459000775 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 702459000776 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 702459000777 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459000778 sugar binding site [chemical binding]; other site 702459000779 Uncharacterized Sugar-binding Domain; Region: FIVAR; pfam07554 702459000780 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 702459000781 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 702459000782 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 702459000783 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459000784 active site 702459000785 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK12323 702459000786 Predicted membrane protein [Function unknown]; Region: COG4640 702459000787 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 702459000788 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 702459000789 Int/Topo IB signature motif; other site 702459000790 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 702459000791 Double zinc ribbon; Region: DZR; pfam12773 702459000792 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 702459000793 YppG-like protein; Region: YppG; pfam14179 702459000794 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 702459000795 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 702459000796 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 702459000797 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 702459000798 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 702459000799 dimer interface [polypeptide binding]; other site 702459000800 ssDNA binding site [nucleotide binding]; other site 702459000801 tetramer (dimer of dimers) interface [polypeptide binding]; other site 702459000802 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 702459000803 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 702459000804 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 702459000805 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 702459000806 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 702459000807 amphipathic channel; other site 702459000808 Asn-Pro-Ala signature motifs; other site 702459000809 galactosyl transferase GMA12/MNN10 family; Region: Glyco_transf_34; cl05288 702459000810 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 702459000811 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 702459000812 active site 702459000813 KMSKS motif; other site 702459000814 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 702459000815 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 702459000816 catalytic residue [active] 702459000817 Acylphosphatase; Region: Acylphosphatase; pfam00708 702459000818 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; cl08459 702459000819 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 702459000820 metal ion-dependent adhesion site (MIDAS); other site 702459000821 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 702459000822 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 702459000823 domain interaction interfaces [polypeptide binding]; other site 702459000824 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 702459000825 Cna protein B-type domain; Region: Cna_B; pfam05738 702459000826 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 702459000827 active site 702459000828 catalytic site [active] 702459000829 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 702459000830 Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415 702459000831 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 702459000832 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 702459000833 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 702459000834 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 702459000835 Clp amino terminal domain; Region: Clp_N; pfam02861 702459000836 Clp amino terminal domain; Region: Clp_N; pfam02861 702459000837 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459000838 Walker A motif; other site 702459000839 ATP binding site [chemical binding]; other site 702459000840 Walker B motif; other site 702459000841 Protein of unknown function (DUF3435); Region: DUF3435; pfam11917 702459000842 arginine finger; other site 702459000843 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459000844 Walker A motif; other site 702459000845 ATP binding site [chemical binding]; other site 702459000846 Walker B motif; other site 702459000847 arginine finger; other site 702459000848 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 702459000849 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 702459000850 Mechanosensitive ion channel; Region: MS_channel; pfam00924 702459000851 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 702459000852 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 702459000853 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 702459000854 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 702459000855 aspartate aminotransferase; Provisional; Region: PRK06836 702459000856 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459000857 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459000858 homodimer interface [polypeptide binding]; other site 702459000859 catalytic residue [active] 702459000860 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 702459000861 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 702459000862 acyl-activating enzyme (AAE) consensus motif; other site 702459000863 putative AMP binding site [chemical binding]; other site 702459000864 putative active site [active] 702459000865 putative CoA binding site [chemical binding]; other site 702459000866 Helix-turn-helix domain; Region: HTH_17; pfam12728 702459000867 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 702459000868 Protein kinase C-related kinase homology region 1 (HR1) domain that binds Rho family small GTPases; Region: HR1; cl00087 702459000869 Rho binding site 1 [polypeptide binding]; other site 702459000870 putative Rho binding site 2 [polypeptide binding]; other site 702459000871 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 702459000872 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 702459000873 Relaxase/Mobilisation nuclease domain; Region: Relaxase; cl19391 702459000874 ParA-like protein; Provisional; Region: PHA02518 702459000875 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 702459000876 P-loop; other site 702459000877 Magnesium ion binding site [ion binding]; other site 702459000878 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 702459000879 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 702459000880 Domain of unknown function (DUF4116); Region: DUF4116; pfam13475 702459000881 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 702459000882 active site 702459000883 metal binding site [ion binding]; metal-binding site 702459000884 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 702459000885 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 702459000886 catalytic residues [active] 702459000887 catalytic nucleophile [active] 702459000888 Recombinase; Region: Recombinase; pfam07508 702459000889 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 702459000890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 702459000891 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 702459000892 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459000893 non-specific DNA binding site [nucleotide binding]; other site 702459000894 salt bridge; other site 702459000895 sequence-specific DNA binding site [nucleotide binding]; other site 702459000896 Protein of unknown function (DUF3682); Region: DUF3682; pfam12446 702459000897 RelB antitoxin; Region: RelB; cl01171 702459000898 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 702459000899 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 702459000900 DNA binding residues [nucleotide binding] 702459000901 dimer interface [polypeptide binding]; other site 702459000902 CpXC protein; Region: CpXC; pfam14353 702459000903 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 702459000904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459000905 putative substrate translocation pore; other site 702459000906 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 702459000907 substrate binding site [chemical binding]; other site 702459000908 ATP binding site [chemical binding]; other site 702459000909 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 702459000910 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 702459000911 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 702459000912 ssDNA binding site; other site 702459000913 generic binding surface II; other site 702459000914 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459000915 ATP binding site [chemical binding]; other site 702459000916 putative Mg++ binding site [ion binding]; other site 702459000917 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459000918 nucleotide binding region [chemical binding]; other site 702459000919 ATP-binding site [chemical binding]; other site 702459000920 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 702459000921 envelope glycoprotein I; Provisional; Region: PHA03292 702459000922 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 702459000923 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 702459000924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459000925 S-adenosylmethionine binding site [chemical binding]; other site 702459000926 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 702459000927 dimer interface [polypeptide binding]; other site 702459000928 FMN binding site [chemical binding]; other site 702459000929 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 702459000930 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 702459000931 putative dimer interface [polypeptide binding]; other site 702459000932 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 702459000933 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 702459000934 RimM N-terminal domain; Region: RimM; pfam01782 702459000935 hypothetical protein; Provisional; Region: PRK02821 702459000936 G-X-X-G motif; other site 702459000937 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 702459000938 ribosomal protein S16; Region: S16; TIGR00002 702459000939 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 702459000940 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 702459000941 DNA-binding site [nucleotide binding]; DNA binding site 702459000942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459000943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459000944 homodimer interface [polypeptide binding]; other site 702459000945 catalytic residue [active] 702459000946 LysE type translocator; Region: LysE; cl00565 702459000947 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 702459000948 putative catalytic site [active] 702459000949 putative metal binding site [ion binding]; other site 702459000950 putative phosphate binding site [ion binding]; other site 702459000951 signal recognition particle protein; Provisional; Region: PRK10867 702459000952 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 702459000953 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 702459000954 P loop; other site 702459000955 GTP binding site [chemical binding]; other site 702459000956 Signal peptide binding domain; Region: SRP_SPB; pfam02978 702459000957 Cation efflux family; Region: Cation_efflux; pfam01545 702459000958 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 702459000959 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 702459000960 active site 702459000961 HIGH motif; other site 702459000962 KMSKS motif; other site 702459000963 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 702459000964 tRNA binding surface [nucleotide binding]; other site 702459000965 anticodon binding site; other site 702459000966 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 702459000967 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 702459000968 catalytic triad [active] 702459000969 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 702459000970 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 702459000971 ABC transporter; Region: ABC_tran_2; pfam12848 702459000972 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 702459000973 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 702459000974 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 702459000975 active site 702459000976 (T/H)XGH motif; other site 702459000977 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 702459000978 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 702459000979 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 702459000980 ribonuclease III; Reviewed; Region: rnc; PRK00102 702459000981 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 702459000982 dimerization interface [polypeptide binding]; other site 702459000983 active site 702459000984 metal binding site [ion binding]; metal-binding site 702459000985 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 702459000986 dsRNA binding site [nucleotide binding]; other site 702459000987 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 702459000988 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 702459000989 PYR/PP interface [polypeptide binding]; other site 702459000990 dimer interface [polypeptide binding]; other site 702459000991 TPP binding site [chemical binding]; other site 702459000992 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 702459000993 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 702459000994 TPP-binding site [chemical binding]; other site 702459000995 dimer interface [polypeptide binding]; other site 702459000996 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 702459000997 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 702459000998 putative valine binding site [chemical binding]; other site 702459000999 dimer interface [polypeptide binding]; other site 702459001000 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 702459001001 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 702459001002 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 702459001003 active site 702459001004 ribonuclease PH; Reviewed; Region: rph; PRK00173 702459001005 Ribonuclease PH; Region: RNase_PH_bact; cd11362 702459001006 hexamer interface [polypeptide binding]; other site 702459001007 active site 702459001008 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 702459001009 active site 702459001010 dimerization interface [polypeptide binding]; other site 702459001011 Membrane transport protein; Region: Mem_trans; cl09117 702459001012 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 702459001013 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 702459001014 active site 702459001015 dimer interface [polypeptide binding]; other site 702459001016 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 702459001017 dimer interface [polypeptide binding]; other site 702459001018 active site 702459001019 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 702459001020 MgtC family; Region: MgtC; pfam02308 702459001021 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 702459001022 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 702459001023 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 702459001024 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 702459001025 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 702459001026 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 702459001027 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 702459001028 Walker A/P-loop; other site 702459001029 ATP binding site [chemical binding]; other site 702459001030 Q-loop/lid; other site 702459001031 ABC transporter signature motif; other site 702459001032 Walker B; other site 702459001033 D-loop; other site 702459001034 H-loop/switch region; other site 702459001035 C-terminal AAA-associated domain; Region: AAA_assoc_C; pfam09821 702459001036 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 702459001037 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459001038 dimer interface [polypeptide binding]; other site 702459001039 conserved gate region; other site 702459001040 putative PBP binding loops; other site 702459001041 ABC-ATPase subunit interface; other site 702459001042 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459001043 dimer interface [polypeptide binding]; other site 702459001044 conserved gate region; other site 702459001045 putative PBP binding loops; other site 702459001046 ABC-ATPase subunit interface; other site 702459001047 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 702459001048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459001049 sequence-specific DNA binding site [nucleotide binding]; other site 702459001050 salt bridge; other site 702459001051 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 702459001052 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 702459001053 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 702459001054 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 702459001055 putative N- and C-terminal domain interface [polypeptide binding]; other site 702459001056 putative active site [active] 702459001057 MgATP binding site [chemical binding]; other site 702459001058 catalytic site [active] 702459001059 metal binding site [ion binding]; metal-binding site 702459001060 putative xylulose binding site [chemical binding]; other site 702459001061 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 702459001062 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 702459001063 AP (apurinic/apyrimidinic) site pocket; other site 702459001064 DNA interaction; other site 702459001065 Metal-binding active site; metal-binding site 702459001066 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 702459001067 intersubunit interface [polypeptide binding]; other site 702459001068 active site 702459001069 Zn2+ binding site [ion binding]; other site 702459001070 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 702459001071 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 702459001072 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 702459001073 Catalytic site [active] 702459001074 Bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 702459001075 RNA/DNA hybrid binding site [nucleotide binding]; other site 702459001076 active site 702459001077 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459001078 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459001079 DNA binding site [nucleotide binding] 702459001080 domain linker motif; other site 702459001081 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 702459001082 ligand binding site [chemical binding]; other site 702459001083 dimerization interface (open form) [polypeptide binding]; other site 702459001084 dimerization interface (closed form) [polypeptide binding]; other site 702459001085 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 702459001086 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 702459001087 acyl-activating enzyme (AAE) consensus motif; other site 702459001088 putative AMP binding site [chemical binding]; other site 702459001089 putative active site [active] 702459001090 putative CoA binding site [chemical binding]; other site 702459001091 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 702459001092 active site 702459001093 multimer interface [polypeptide binding]; other site 702459001094 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 702459001095 predicted active site [active] 702459001096 catalytic triad [active] 702459001097 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 702459001098 active site 702459001099 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459001100 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459001101 DNA binding site [nucleotide binding] 702459001102 domain linker motif; other site 702459001103 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 702459001104 ligand binding site [chemical binding]; other site 702459001105 dimerization interface [polypeptide binding]; other site 702459001106 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 702459001107 active site 702459001108 catalytic tetrad [active] 702459001109 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 702459001110 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 702459001111 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 702459001112 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459001113 Major Facilitator Superfamily; Region: MFS_1; pfam07690 702459001114 putative substrate translocation pore; other site 702459001115 envelope glycoprotein I; Provisional; Region: PHA03291 702459001116 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 702459001117 Domain of unknown function (DUF348); Region: DUF348; pfam03990 702459001118 G5 domain; Region: G5; pfam07501 702459001119 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 702459001120 catalytic residue [active] 702459001121 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 702459001122 catalytic residues [active] 702459001123 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 702459001124 nudix motif; other site 702459001125 Putative lysophospholipase; Region: Hydrolase_4; cl19140 702459001126 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 702459001127 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 702459001128 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 702459001129 putative NADH binding site [chemical binding]; other site 702459001130 putative active site [active] 702459001131 nudix motif; other site 702459001132 putative metal binding site [ion binding]; other site 702459001133 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 702459001134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 702459001135 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 702459001136 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 702459001137 lipoyl attachment site [posttranslational modification]; other site 702459001138 Uncharacterized conserved protein (DUF2183); Region: DUF2183; cl19874 702459001139 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 702459001140 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 702459001141 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 702459001142 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 702459001143 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 702459001144 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 702459001145 ligand binding site [chemical binding]; other site 702459001146 flexible hinge region; other site 702459001147 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 702459001148 putative switch regulator; other site 702459001149 non-specific DNA interactions [nucleotide binding]; other site 702459001150 DNA binding site [nucleotide binding] 702459001151 sequence specific DNA binding site [nucleotide binding]; other site 702459001152 putative cAMP binding site [chemical binding]; other site 702459001153 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 702459001154 Transglycosylase; Region: Transgly; pfam00912 702459001155 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 702459001156 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 702459001157 active site 702459001158 FMN binding site [chemical binding]; other site 702459001159 substrate binding site [chemical binding]; other site 702459001160 homotetramer interface [polypeptide binding]; other site 702459001161 catalytic residue [active] 702459001162 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 702459001163 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 702459001164 quinone interaction residues [chemical binding]; other site 702459001165 active site 702459001166 catalytic residues [active] 702459001167 FMN binding site [chemical binding]; other site 702459001168 substrate binding site [chemical binding]; other site 702459001169 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 702459001170 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 702459001171 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 702459001172 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 702459001173 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 702459001174 dimer interface [polypeptide binding]; other site 702459001175 active site 702459001176 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 702459001177 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 702459001178 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 702459001179 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 702459001180 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459001181 metabolite-proton symporter; Region: 2A0106; TIGR00883 702459001182 putative substrate translocation pore; other site 702459001183 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 702459001184 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 702459001185 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl19158 702459001186 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 702459001187 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 702459001188 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 702459001189 minor groove reading motif; other site 702459001190 helix-hairpin-helix signature motif; other site 702459001191 active site 702459001192 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 702459001193 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 702459001194 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 702459001195 RPB12 interaction site [polypeptide binding]; other site 702459001196 RPB1 interaction site [polypeptide binding]; other site 702459001197 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 702459001198 RPB10 interaction site [polypeptide binding]; other site 702459001199 RPB11 interaction site [polypeptide binding]; other site 702459001200 RPB3 interaction site [polypeptide binding]; other site 702459001201 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 702459001202 Largest subunit (beta') of bacterial DNA-dependent RNA polymerase (RNAP), N-terminal domain; Region: RNAP_beta'_N; cd01609 702459001203 beta and beta' interface [polypeptide binding]; other site 702459001204 beta' and sigma factor interface [polypeptide binding]; other site 702459001205 Zn-binding [ion binding]; other site 702459001206 active site region [active] 702459001207 catalytic site [active] 702459001208 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 702459001209 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 702459001210 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 702459001211 G-loop; other site 702459001212 DNA binding site [nucleotide binding] 702459001213 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 702459001214 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 702459001215 phosphopeptide binding site; other site 702459001216 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 702459001217 active site 702459001218 Sodium Bile acid symporter family; Region: SBF; cl19217 702459001219 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 702459001220 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 702459001221 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 702459001222 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 702459001223 Protein of unknown function DUF58; Region: DUF58; pfam01882 702459001224 MoxR-like ATPases [General function prediction only]; Region: COG0714 702459001225 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459001226 Walker A motif; other site 702459001227 ATP binding site [chemical binding]; other site 702459001228 Walker B motif; other site 702459001229 arginine finger; other site 702459001230 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 702459001231 Interdomain contacts; other site 702459001232 Cytokine receptor motif; other site 702459001233 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 702459001234 Interdomain contacts; other site 702459001235 Cytokine receptor motif; other site 702459001236 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 702459001237 Catalytic domain of Protein Kinases; Region: PKc; cd00180 702459001238 active site 702459001239 ATP binding site [chemical binding]; other site 702459001240 substrate binding site [chemical binding]; other site 702459001241 activation loop (A-loop); other site 702459001242 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459001243 Walker A/P-loop; other site 702459001244 ATP binding site [chemical binding]; other site 702459001245 Q-loop/lid; other site 702459001246 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 702459001247 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 702459001248 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 702459001249 Part of AAA domain; Region: AAA_19; pfam13245 702459001250 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 702459001251 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 702459001252 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 702459001253 Coenzyme A binding pocket [chemical binding]; other site 702459001254 Major Facilitator Superfamily; Region: MFS_1; pfam07690 702459001255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459001256 RelB antitoxin; Region: RelB; cl01171 702459001257 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 702459001258 SAM (Sterile alpha motif ); Region: SAM_superfamily; cl15755 702459001259 dihydrodipicolinate reductase; Provisional; Region: PRK00048 702459001260 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 702459001261 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 702459001262 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 702459001263 dimer interface [polypeptide binding]; other site 702459001264 active site 702459001265 catalytic residue [active] 702459001266 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 702459001267 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 702459001268 RNA-metabolizing metallo-beta-lactamase; Region: RMMBL; pfam07521 702459001269 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 702459001270 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 702459001271 Zn binding site [ion binding]; other site 702459001272 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 702459001273 ERAP1-like C-terminal domain; Region: ERAP1_C; pfam11838 702459001274 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 702459001275 active site 702459001276 catalytic residues [active] 702459001277 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 702459001278 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 702459001279 active site 702459001280 substrate binding site [chemical binding]; other site 702459001281 metal binding site [ion binding]; metal-binding site 702459001282 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 702459001283 active site 702459001284 catalytic residues [active] 702459001285 metal binding site [ion binding]; metal-binding site 702459001286 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 702459001287 additional DNA contacts [nucleotide binding]; other site 702459001288 mismatch recognition site; other site 702459001289 active site 702459001290 zinc binding site [ion binding]; other site 702459001291 DNA intercalation site [nucleotide binding]; other site 702459001292 aminotransferase; Validated; Region: PRK07337 702459001293 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459001294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459001295 homodimer interface [polypeptide binding]; other site 702459001296 catalytic residue [active] 702459001297 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 702459001298 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 702459001299 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 702459001300 ATP binding site [chemical binding]; other site 702459001301 substrate interface [chemical binding]; other site 702459001302 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 702459001303 active site residue [active] 702459001304 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 702459001305 CPxP motif; other site 702459001306 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 702459001307 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 702459001308 active site 702459001309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459001310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459001311 DNA binding site [nucleotide binding] 702459001312 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 702459001313 putative catalytic site [active] 702459001314 putative metal binding site [ion binding]; other site 702459001315 putative phosphate binding site [ion binding]; other site 702459001316 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 702459001317 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 702459001318 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 702459001319 generic binding surface II; other site 702459001320 generic binding surface I; other site 702459001321 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 702459001322 ATP cone domain; Region: ATP-cone; pfam03477 702459001323 Class III ribonucleotide reductase; Region: RNR_III; cd01675 702459001324 effector binding site; other site 702459001325 active site 702459001326 Zn binding site [ion binding]; other site 702459001327 glycine loop; other site 702459001328 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 702459001329 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 702459001330 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 702459001331 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 702459001332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 702459001333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 702459001334 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 702459001335 Right handed beta helix region; Region: Beta_helix; pfam13229 702459001336 Transcriptional regulators [Transcription]; Region: MarR; COG1846 702459001337 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 702459001338 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 702459001339 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 702459001340 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459001341 Walker A/P-loop; other site 702459001342 ATP binding site [chemical binding]; other site 702459001343 Q-loop/lid; other site 702459001344 ABC transporter signature motif; other site 702459001345 Walker B; other site 702459001346 D-loop; other site 702459001347 H-loop/switch region; other site 702459001348 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 702459001349 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 702459001350 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 702459001351 Walker A/P-loop; other site 702459001352 ATP binding site [chemical binding]; other site 702459001353 Q-loop/lid; other site 702459001354 ABC transporter signature motif; other site 702459001355 Walker B; other site 702459001356 D-loop; other site 702459001357 H-loop/switch region; other site 702459001358 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 702459001359 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 702459001360 active site 702459001361 nucleophile elbow; other site 702459001362 glutamate racemase; Provisional; Region: PRK00865 702459001363 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 702459001364 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 702459001365 Diaminopimelate epimerase; Region: DAP_epimerase; cl19724 702459001366 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 702459001367 putative active site [active] 702459001368 redox center [active] 702459001369 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 702459001370 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 702459001371 active site 702459001372 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 702459001373 Phosphotransferase enzyme family; Region: APH; pfam01636 702459001374 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 702459001375 substrate binding site [chemical binding]; other site 702459001376 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 702459001377 Part of AAA domain; Region: AAA_19; pfam13245 702459001378 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 702459001379 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 702459001380 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 702459001381 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 702459001382 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459001383 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459001384 DNA binding site [nucleotide binding] 702459001385 domain linker motif; other site 702459001386 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 702459001387 putative dimerization interface [polypeptide binding]; other site 702459001388 putative ligand binding site [chemical binding]; other site 702459001389 Domain of unknown function DUF77; Region: DUF77; pfam01910 702459001390 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 702459001391 substrate binding site [chemical binding]; other site 702459001392 dimer interface [polypeptide binding]; other site 702459001393 ATP binding site [chemical binding]; other site 702459001394 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459001395 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 702459001396 Walker A motif; other site 702459001397 ATP binding site [chemical binding]; other site 702459001398 Walker B motif; other site 702459001399 arginine finger; other site 702459001400 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 702459001401 thiamine phosphate binding site [chemical binding]; other site 702459001402 active site 702459001403 pyrophosphate binding site [ion binding]; other site 702459001404 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 702459001405 ThiC-associated domain; Region: ThiC-associated; pfam13667 702459001406 ThiC family; Region: ThiC; pfam01964 702459001407 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 702459001408 substrate binding site [chemical binding]; other site 702459001409 multimerization interface [polypeptide binding]; other site 702459001410 ATP binding site [chemical binding]; other site 702459001411 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 702459001412 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 702459001413 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 702459001414 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 702459001415 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 702459001416 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 702459001417 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 702459001418 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 702459001419 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459001420 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459001421 sugar binding site [chemical binding]; other site 702459001422 glycyl-tRNA synthetase; Provisional; Region: PRK04173 702459001423 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 702459001424 dimer interface [polypeptide binding]; other site 702459001425 motif 1; other site 702459001426 active site 702459001427 motif 2; other site 702459001428 motif 3; other site 702459001429 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 702459001430 anticodon binding site; other site 702459001431 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 702459001432 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 702459001433 FMN binding site [chemical binding]; other site 702459001434 active site 702459001435 catalytic residues [active] 702459001436 substrate binding site [chemical binding]; other site 702459001437 cell division protein FtsZ; Validated; Region: PRK09330 702459001438 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 702459001439 nucleotide binding site [chemical binding]; other site 702459001440 SulA interaction site; other site 702459001441 Protein of unknown function (DUF552); Region: DUF552; pfam04472 702459001442 YGGT family; Region: YGGT; pfam02325 702459001443 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 702459001444 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 702459001445 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 702459001446 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 702459001447 active site 702459001448 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 702459001449 Tetrahydrodipicolinate N-succinyltransferase N-terminal; Region: THDPS_N; pfam14790 702459001450 Tetrahydrodipicolinate N-succinyltransferase middle; Region: THDPS_M; pfam14789 702459001451 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 702459001452 putative trimer interface [polypeptide binding]; other site 702459001453 putative CoA binding site [chemical binding]; other site 702459001454 peptide chain release factor 2; Validated; Region: prfB; PRK00578 702459001455 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 702459001456 This domain is found in peptide chain release factors; Region: PCRF; smart00937 702459001457 RF-1 domain; Region: RF-1; pfam00472 702459001458 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 702459001459 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459001460 Walker A/P-loop; other site 702459001461 ATP binding site [chemical binding]; other site 702459001462 Q-loop/lid; other site 702459001463 ABC transporter signature motif; other site 702459001464 Walker B; other site 702459001465 D-loop; other site 702459001466 H-loop/switch region; other site 702459001467 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 702459001468 FtsX-like permease family; Region: FtsX; pfam02687 702459001469 CHAP domain; Region: CHAP; pfam05257 702459001470 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 702459001471 SmpB-tmRNA interface; other site 702459001472 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 702459001473 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 702459001474 active site 702459001475 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 702459001476 DivIVA domain; Region: DivI1A_domain; TIGR03544 702459001477 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 702459001478 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 702459001479 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 702459001480 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 702459001481 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 702459001482 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate synthase; Region: ispG_gcpE; TIGR00612 702459001483 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 702459001484 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 702459001485 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 702459001486 Recombination protein O N terminal; Region: RecO_N; pfam11967 702459001487 Recombination protein O C terminal; Region: RecO_C; pfam02565 702459001488 Cis (Z)-Isoprenyl Diphosphate Synthases; Region: Cis_IPPS; cd00475 702459001489 active site 702459001490 dimer interface [polypeptide binding]; other site 702459001491 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 702459001492 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 702459001493 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 702459001494 active site 702459001495 PHP Thumb interface [polypeptide binding]; other site 702459001496 metal binding site [ion binding]; metal-binding site 702459001497 Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733 702459001498 Helix-hairpin-helix motif; Region: HHH_6; pfam14579 702459001499 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 702459001500 generic binding surface II; other site 702459001501 generic binding surface I; other site 702459001502 Double zinc ribbon; Region: DZR; pfam12773 702459001503 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 702459001504 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 702459001505 myosin-cross-reactive antigen; Provisional; Region: PRK13977 702459001506 Streptococcal 67 kDa myosin-cross-reactive antigen like family; Region: Strep_67kDa_ant; pfam06100 702459001507 HTH domain; Region: HTH_11; pfam08279 702459001508 Predicted transcriptional regulator [Transcription]; Region: COG2378 702459001509 WYL domain; Region: WYL; pfam13280 702459001510 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 702459001511 active site 702459001512 catalytic tetrad [active] 702459001513 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 702459001514 active site 702459001515 catalytic tetrad [active] 702459001516 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 702459001517 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 702459001518 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 702459001519 NAD binding site [chemical binding]; other site 702459001520 dimerization interface [polypeptide binding]; other site 702459001521 product binding site; other site 702459001522 substrate binding site [chemical binding]; other site 702459001523 zinc binding site [ion binding]; other site 702459001524 catalytic residues [active] 702459001525 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 702459001526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459001527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459001528 homodimer interface [polypeptide binding]; other site 702459001529 catalytic residue [active] 702459001530 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 702459001531 putative active site pocket [active] 702459001532 4-fold oligomerization interface [polypeptide binding]; other site 702459001533 metal binding residues [ion binding]; metal-binding site 702459001534 3-fold/trimer interface [polypeptide binding]; other site 702459001535 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 702459001536 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13142 702459001537 putative active site [active] 702459001538 oxyanion strand; other site 702459001539 catalytic triad [active] 702459001540 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 702459001541 catalytic residues [active] 702459001542 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 702459001543 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 702459001544 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 702459001545 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 702459001546 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 702459001547 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 702459001548 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 702459001549 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459001550 ATP binding site [chemical binding]; other site 702459001551 putative Mg++ binding site [ion binding]; other site 702459001552 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459001553 nucleotide binding region [chemical binding]; other site 702459001554 ATP-binding site [chemical binding]; other site 702459001555 Helicase associated domain (HA2); Region: HA2; pfam04408 702459001556 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 702459001557 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 702459001558 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 702459001559 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459001560 S-adenosylmethionine binding site [chemical binding]; other site 702459001561 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 702459001562 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 702459001563 HflX GTPase family; Region: HflX; cd01878 702459001564 G1 box; other site 702459001565 GTP/Mg2+ binding site [chemical binding]; other site 702459001566 Switch I region; other site 702459001567 G2 box; other site 702459001568 G3 box; other site 702459001569 Switch II region; other site 702459001570 G4 box; other site 702459001571 G5 box; other site 702459001572 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 702459001573 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 702459001574 NAD binding site [chemical binding]; other site 702459001575 dimer interface [polypeptide binding]; other site 702459001576 substrate binding site [chemical binding]; other site 702459001577 tetramer (dimer of dimers) interface [polypeptide binding]; other site 702459001578 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 702459001579 LexA repressor; Validated; Region: PRK00215 702459001580 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 702459001581 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 702459001582 Catalytic site [active] 702459001583 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 702459001584 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 702459001585 ATP cone domain; Region: ATP-cone; pfam03477 702459001586 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 702459001587 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 702459001588 ligand binding site [chemical binding]; other site 702459001589 NAD binding site [chemical binding]; other site 702459001590 tetramer interface [polypeptide binding]; other site 702459001591 catalytic site [active] 702459001592 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 702459001593 L-serine binding site [chemical binding]; other site 702459001594 ACT domain interface; other site 702459001595 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 702459001596 Part of AAA domain; Region: AAA_19; pfam13245 702459001597 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 702459001598 MraZ protein; Region: MraZ; pfam02381 702459001599 cell division protein MraZ; Reviewed; Region: PRK00326 702459001600 MraZ protein; Region: MraZ; pfam02381 702459001601 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 702459001602 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 702459001603 Penicillin-binding Protein dimerization domain; Region: PBP_dimer; pfam03717 702459001604 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 702459001605 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 702459001606 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 702459001607 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 702459001608 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 702459001609 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 702459001610 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 702459001611 Mg++ binding site [ion binding]; other site 702459001612 putative catalytic motif [active] 702459001613 putative substrate binding site [chemical binding]; other site 702459001614 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 702459001615 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 702459001616 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 702459001617 cell division protein FtsW; Region: ftsW; TIGR02614 702459001618 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 702459001619 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 702459001620 active site 702459001621 homodimer interface [polypeptide binding]; other site 702459001622 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 702459001623 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 702459001624 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 702459001625 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 702459001626 cell division protein FtsQ; Provisional; Region: PRK05529 702459001627 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 702459001628 D-tyrosyl-tRNA(Tyr) deacylase; Provisional; Region: PRK05273 702459001629 putative active site [active] 702459001630 dimerization interface [polypeptide binding]; other site 702459001631 putative tRNAtyr binding site [nucleotide binding]; other site 702459001632 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459001633 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 702459001634 putative substrate translocation pore; other site 702459001635 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 702459001636 putative substrate binding site [chemical binding]; other site 702459001637 putative ATP binding site [chemical binding]; other site 702459001638 dimerization interface [polypeptide binding]; other site 702459001639 putative DNA binding site [nucleotide binding]; other site 702459001640 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 702459001641 Transcriptional regulators [Transcription]; Region: MarR; COG1846 702459001642 putative Zn2+ binding site [ion binding]; other site 702459001643 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 702459001644 nucleotide binding site [chemical binding]; other site 702459001645 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 702459001646 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 702459001647 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 702459001648 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 702459001649 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 702459001650 active site 702459001651 trimer interface [polypeptide binding]; other site 702459001652 allosteric site; other site 702459001653 active site lid [active] 702459001654 hexamer (dimer of trimers) interface [polypeptide binding]; other site 702459001655 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 702459001656 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 702459001657 active site 702459001658 dimer interface [polypeptide binding]; other site 702459001659 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 702459001660 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 702459001661 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 702459001662 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459001663 dimer interface [polypeptide binding]; other site 702459001664 conserved gate region; other site 702459001665 putative PBP binding loops; other site 702459001666 ABC-ATPase subunit interface; other site 702459001667 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 702459001668 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 702459001669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459001670 dimer interface [polypeptide binding]; other site 702459001671 conserved gate region; other site 702459001672 putative PBP binding loops; other site 702459001673 ABC-ATPase subunit interface; other site 702459001674 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 702459001675 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 702459001676 Walker A/P-loop; other site 702459001677 ATP binding site [chemical binding]; other site 702459001678 Q-loop/lid; other site 702459001679 ABC transporter signature motif; other site 702459001680 Walker B; other site 702459001681 D-loop; other site 702459001682 H-loop/switch region; other site 702459001683 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 702459001684 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 702459001685 Walker A/P-loop; other site 702459001686 ATP binding site [chemical binding]; other site 702459001687 Q-loop/lid; other site 702459001688 ABC transporter signature motif; other site 702459001689 Walker B; other site 702459001690 D-loop; other site 702459001691 H-loop/switch region; other site 702459001692 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 702459001693 proline aminopeptidase P II; Provisional; Region: PRK10879 702459001694 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 702459001695 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 702459001696 active site 702459001697 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 702459001698 nudix motif; other site 702459001699 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 702459001700 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 702459001701 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 702459001702 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 702459001703 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 702459001704 Walker A/P-loop; other site 702459001705 ATP binding site [chemical binding]; other site 702459001706 The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013 702459001707 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 702459001708 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 702459001709 ABC transporter signature motif; other site 702459001710 Walker B; other site 702459001711 D-loop; other site 702459001712 H-loop/switch region; other site 702459001713 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 702459001714 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 702459001715 ATP-grasp domain; Region: ATP-grasp_4; cl17255 702459001716 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 702459001717 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 702459001718 catalytic residue [active] 702459001719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 702459001720 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 702459001721 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 702459001722 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 702459001723 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 702459001724 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 702459001725 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 702459001726 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 702459001727 DNA binding residues [nucleotide binding] 702459001728 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 702459001729 active site 702459001730 catalytic residues [active] 702459001731 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Region: lytB_ispH; cd13944 702459001732 Fe-S cluster binding site [ion binding]; other site 702459001733 substrate binding site [chemical binding]; other site 702459001734 catalytic site [active] 702459001735 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 702459001736 putative deacylase active site [active] 702459001737 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044 702459001738 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 702459001739 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 702459001740 Thiamine pyrophosphokinase; Region: TPK; cd07995 702459001741 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 702459001742 active site 702459001743 dimerization interface [polypeptide binding]; other site 702459001744 thiamine binding site [chemical binding]; other site 702459001745 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 702459001746 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 702459001747 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 702459001748 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 702459001749 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 702459001750 23S rRNA binding site [nucleotide binding]; other site 702459001751 L21 binding site [polypeptide binding]; other site 702459001752 L13 binding site [polypeptide binding]; other site 702459001753 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 702459001754 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 702459001755 active site 702459001756 DNA binding site [nucleotide binding] 702459001757 Int/Topo IB signature motif; other site 702459001758 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 702459001759 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 702459001760 P-loop; other site 702459001761 Magnesium ion binding site [ion binding]; other site 702459001762 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 702459001763 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 702459001764 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 702459001765 nudix motif; other site 702459001766 quinolinate synthetase; Provisional; Region: PRK09375 702459001767 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 702459001768 L-aspartate oxidase; Provisional; Region: PRK06175 702459001769 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 702459001770 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 702459001771 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 702459001772 dimerization interface [polypeptide binding]; other site 702459001773 active site 702459001774 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 702459001775 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 702459001776 catalytic residue [active] 702459001777 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 702459001778 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 702459001779 G1 box; other site 702459001780 putative GEF interaction site [polypeptide binding]; other site 702459001781 GTP/Mg2+ binding site [chemical binding]; other site 702459001782 Switch I region; other site 702459001783 G2 box; other site 702459001784 G3 box; other site 702459001785 Switch II region; other site 702459001786 G4 box; other site 702459001787 G5 box; other site 702459001788 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 702459001789 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 702459001790 Prephenate dehydratase; Region: PDT; pfam00800 702459001791 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 702459001792 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 702459001793 putative L-Phe binding site [chemical binding]; other site 702459001794 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 702459001795 prephenate dehydrogenase; Validated; Region: PRK08507 702459001796 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 702459001797 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 702459001798 active site 702459001799 DNA binding site [nucleotide binding] 702459001800 Int/Topo IB signature motif; other site 702459001801 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 702459001802 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459001803 dimer interface [polypeptide binding]; other site 702459001804 conserved gate region; other site 702459001805 putative PBP binding loops; other site 702459001806 ABC-ATPase subunit interface; other site 702459001807 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 702459001808 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 702459001809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459001810 dimer interface [polypeptide binding]; other site 702459001811 conserved gate region; other site 702459001812 putative PBP binding loops; other site 702459001813 ABC-ATPase subunit interface; other site 702459001814 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 702459001815 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 702459001816 Walker A/P-loop; other site 702459001817 ATP binding site [chemical binding]; other site 702459001818 Q-loop/lid; other site 702459001819 ABC transporter signature motif; other site 702459001820 Walker B; other site 702459001821 D-loop; other site 702459001822 H-loop/switch region; other site 702459001823 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 702459001824 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 702459001825 Walker A/P-loop; other site 702459001826 ATP binding site [chemical binding]; other site 702459001827 Q-loop/lid; other site 702459001828 ABC transporter signature motif; other site 702459001829 Walker B; other site 702459001830 D-loop; other site 702459001831 H-loop/switch region; other site 702459001832 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 702459001833 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 702459001834 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 702459001835 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 702459001836 trimer interface [polypeptide binding]; other site 702459001837 active site 702459001838 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 702459001839 putative active site [active] 702459001840 putative catalytic site [active] 702459001841 putative DNA binding site [nucleotide binding]; other site 702459001842 putative phosphate binding site [ion binding]; other site 702459001843 metal binding site A [ion binding]; metal-binding site 702459001844 putative AP binding site [nucleotide binding]; other site 702459001845 putative metal binding site B [ion binding]; other site 702459001846 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 702459001847 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 702459001848 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 702459001849 TRAM domain; Region: TRAM; cl01282 702459001850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459001851 S-adenosylmethionine binding site [chemical binding]; other site 702459001852 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 702459001853 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 702459001854 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 702459001855 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 702459001856 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 702459001857 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 702459001858 aconitate hydratase; Validated; Region: PRK09277 702459001859 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 702459001860 substrate binding site [chemical binding]; other site 702459001861 ligand binding site [chemical binding]; other site 702459001862 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 702459001863 substrate binding site [chemical binding]; other site 702459001864 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 702459001865 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 702459001866 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 702459001867 S-adenosylmethionine synthetase; Validated; Region: PRK05250 702459001868 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 702459001869 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 702459001870 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 702459001871 primosome assembly protein PriA; Provisional; Region: PRK14873 702459001872 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 702459001873 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459001874 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 702459001875 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 702459001876 putative active site [active] 702459001877 substrate binding site [chemical binding]; other site 702459001878 putative cosubstrate binding site; other site 702459001879 catalytic site [active] 702459001880 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 702459001881 substrate binding site [chemical binding]; other site 702459001882 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 702459001883 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459001884 motif II; other site 702459001885 proteasome ATPase; Region: pup_AAA; TIGR03689 702459001886 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459001887 Walker A motif; other site 702459001888 ATP binding site [chemical binding]; other site 702459001889 Walker B motif; other site 702459001890 arginine finger; other site 702459001891 Pup-ligase protein; Region: Pup_ligase; cl15463 702459001892 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 702459001893 active site 702459001894 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 702459001895 Pup-ligase protein; Region: Pup_ligase; cl15463 702459001896 Bacteriophage SPO1-encoded TF1 binds and bends DNA; Region: SPO1_TF1_like; cd14435 702459001897 putative DNA binding site [nucleotide binding]; other site 702459001898 dimer interface [polypeptide binding]; other site 702459001899 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 702459001900 adenylosuccinate lyase; Provisional; Region: PRK09285 702459001901 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 702459001902 tetramer interface [polypeptide binding]; other site 702459001903 active site 702459001904 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 702459001905 Putative lysophospholipase; Region: Hydrolase_4; cl19140 702459001906 von Willebrand factor type A domain; Region: VWA_2; pfam13519 702459001907 metal ion-dependent adhesion site (MIDAS); other site 702459001908 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 702459001909 metal ion-dependent adhesion site (MIDAS); other site 702459001910 Phytoreovirus nonstructural protein Pns10/11; Region: Phytoreo_Pns; pfam05451 702459001911 Protein of unknown function DUF58; Region: DUF58; pfam01882 702459001912 MoxR-like ATPases [General function prediction only]; Region: COG0714 702459001913 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459001914 Walker A motif; other site 702459001915 ATP binding site [chemical binding]; other site 702459001916 Walker B motif; other site 702459001917 arginine finger; other site 702459001918 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 702459001919 ligand binding site [chemical binding]; other site 702459001920 active site 702459001921 UGI interface [polypeptide binding]; other site 702459001922 catalytic site [active] 702459001923 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 702459001924 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 702459001925 DNA-binding site [nucleotide binding]; DNA binding site 702459001926 RNA-binding motif; other site 702459001927 chaperonin GroEL; Reviewed; Region: groEL; PRK12850 702459001928 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 702459001929 ring oligomerisation interface [polypeptide binding]; other site 702459001930 ATP/Mg binding site [chemical binding]; other site 702459001931 stacking interactions; other site 702459001932 hinge regions; other site 702459001933 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 702459001934 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 702459001935 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459001936 active site 702459001937 phosphorylation site [posttranslational modification] 702459001938 intermolecular recognition site; other site 702459001939 dimerization interface [polypeptide binding]; other site 702459001940 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 702459001941 DNA binding site [nucleotide binding] 702459001942 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 702459001943 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 702459001944 dimerization interface [polypeptide binding]; other site 702459001945 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 702459001946 dimer interface [polypeptide binding]; other site 702459001947 phosphorylation site [posttranslational modification] 702459001948 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459001949 ATP binding site [chemical binding]; other site 702459001950 Mg2+ binding site [ion binding]; other site 702459001951 G-X-G motif; other site 702459001952 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 702459001953 DNA-binding site [nucleotide binding]; DNA binding site 702459001954 RNA-binding motif; other site 702459001955 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cl18951 702459001956 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 702459001957 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 702459001958 Ligand Binding Site [chemical binding]; other site 702459001959 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 702459001960 Ligand Binding Site [chemical binding]; other site 702459001961 Clp protease ATP binding subunit; Region: clpC; CHL00095 702459001962 Clp amino terminal domain; Region: Clp_N; pfam02861 702459001963 Clp amino terminal domain; Region: Clp_N; pfam02861 702459001964 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459001965 Walker A motif; other site 702459001966 ATP binding site [chemical binding]; other site 702459001967 Walker B motif; other site 702459001968 arginine finger; other site 702459001969 UvrB/uvrC motif; Region: UVR; pfam02151 702459001970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459001971 Walker A motif; other site 702459001972 ATP binding site [chemical binding]; other site 702459001973 Walker B motif; other site 702459001974 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 702459001975 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 702459001976 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 702459001977 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 702459001978 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 702459001979 dimer interface [polypeptide binding]; other site 702459001980 active site 702459001981 motif 2; other site 702459001982 motif 3; other site 702459001983 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 702459001984 anticodon binding site; other site 702459001985 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 702459001986 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 702459001987 dimer interface [polypeptide binding]; other site 702459001988 anticodon binding site; other site 702459001989 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 702459001990 homodimer interface [polypeptide binding]; other site 702459001991 motif 1; other site 702459001992 active site 702459001993 motif 2; other site 702459001994 GAD domain; Region: GAD; pfam02938 702459001995 motif 3; other site 702459001996 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459001997 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 702459001998 active site 702459001999 phosphorylation site [posttranslational modification] 702459002000 intermolecular recognition site; other site 702459002001 dimerization interface [polypeptide binding]; other site 702459002002 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 702459002003 DNA binding residues [nucleotide binding] 702459002004 dimerization interface [polypeptide binding]; other site 702459002005 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 702459002006 putative deacylase active site [active] 702459002007 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 702459002008 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 702459002009 Walker A/P-loop; other site 702459002010 ATP binding site [chemical binding]; other site 702459002011 Q-loop/lid; other site 702459002012 ABC transporter signature motif; other site 702459002013 Walker B; other site 702459002014 D-loop; other site 702459002015 H-loop/switch region; other site 702459002016 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 702459002017 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 702459002018 substrate binding pocket [chemical binding]; other site 702459002019 membrane-bound complex binding site; other site 702459002020 hinge residues; other site 702459002021 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 702459002022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459002023 dimer interface [polypeptide binding]; other site 702459002024 conserved gate region; other site 702459002025 putative PBP binding loops; other site 702459002026 ABC-ATPase subunit interface; other site 702459002027 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: HisM; COG0765 702459002028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459002029 dimer interface [polypeptide binding]; other site 702459002030 conserved gate region; other site 702459002031 putative PBP binding loops; other site 702459002032 ABC-ATPase subunit interface; other site 702459002033 Polyphosphate kinase 2 (PPK2); Region: PPK2; cl11971 702459002034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459002035 ATP binding site [chemical binding]; other site 702459002036 putative Mg++ binding site [ion binding]; other site 702459002037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459002038 nucleotide binding region [chemical binding]; other site 702459002039 ATP-binding site [chemical binding]; other site 702459002040 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 702459002041 recombination factor protein RarA; Reviewed; Region: PRK13342 702459002042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459002043 Walker A motif; other site 702459002044 ATP binding site [chemical binding]; other site 702459002045 Walker B motif; other site 702459002046 arginine finger; other site 702459002047 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 702459002048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459002049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 702459002050 putative substrate translocation pore; other site 702459002051 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 702459002052 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 702459002053 Walker A/P-loop; other site 702459002054 ATP binding site [chemical binding]; other site 702459002055 Q-loop/lid; other site 702459002056 ABC transporter signature motif; other site 702459002057 Walker B; other site 702459002058 D-loop; other site 702459002059 H-loop/switch region; other site 702459002060 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 702459002061 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 702459002062 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 702459002063 Walker A/P-loop; other site 702459002064 ATP binding site [chemical binding]; other site 702459002065 Q-loop/lid; other site 702459002066 ABC transporter signature motif; other site 702459002067 Walker B; other site 702459002068 D-loop; other site 702459002069 H-loop/switch region; other site 702459002070 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 702459002071 Predicted membrane protein [Function unknown]; Region: COG3601 702459002072 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 702459002073 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 702459002074 nucleotide binding site [chemical binding]; other site 702459002075 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459002076 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459002077 homodimer interface [polypeptide binding]; other site 702459002078 catalytic residue [active] 702459002079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459002080 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 702459002081 Walker A/P-loop; other site 702459002082 ATP binding site [chemical binding]; other site 702459002083 Q-loop/lid; other site 702459002084 ABC transporter signature motif; other site 702459002085 Walker B; other site 702459002086 D-loop; other site 702459002087 H-loop/switch region; other site 702459002088 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 702459002089 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 702459002090 binding surface 702459002091 TPR motif; other site 702459002092 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 702459002093 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 702459002094 nucleotide binding pocket [chemical binding]; other site 702459002095 K-X-D-G motif; other site 702459002096 catalytic site [active] 702459002097 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 702459002098 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 702459002099 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 702459002100 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 702459002101 Dimer interface [polypeptide binding]; other site 702459002102 Domain of unknown function DUF59; Region: DUF59; cl00941 702459002103 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 702459002104 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 702459002105 Walker A motif; other site 702459002106 glutamine synthetase, type I; Region: GlnA; TIGR00653 702459002107 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 702459002108 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 702459002109 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 702459002110 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 702459002111 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 702459002112 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 702459002113 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 702459002114 hypothetical protein; Provisional; Region: PRK08201 702459002115 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 702459002116 active site 702459002117 metal binding site [ion binding]; metal-binding site 702459002118 dimer interface [polypeptide binding]; other site 702459002119 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459002120 cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673 702459002121 Walker A/P-loop; other site 702459002122 ATP binding site [chemical binding]; other site 702459002123 Q-loop/lid; other site 702459002124 ABC transporter signature motif; other site 702459002125 Walker B; other site 702459002126 D-loop; other site 702459002127 H-loop/switch region; other site 702459002128 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; cl12363 702459002129 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 702459002130 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 702459002131 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 702459002132 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 702459002133 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 702459002134 Acyltransferase family; Region: Acyl_transf_3; pfam01757 702459002135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3551 702459002136 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 702459002137 substrate binding site; other site 702459002138 dimer interface; other site 702459002139 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 702459002140 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 702459002141 NAD(P) binding site [chemical binding]; other site 702459002142 active site 702459002143 ABC-2 type transporter; Region: ABC2_membrane; cl17235 702459002144 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 702459002145 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 702459002146 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 702459002147 Walker A/P-loop; other site 702459002148 ATP binding site [chemical binding]; other site 702459002149 Q-loop/lid; other site 702459002150 ABC transporter signature motif; other site 702459002151 Walker B; other site 702459002152 D-loop; other site 702459002153 H-loop/switch region; other site 702459002154 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 702459002155 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 702459002156 Coenzyme A binding pocket [chemical binding]; other site 702459002157 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 702459002158 putative active site [active] 702459002159 catalytic residue [active] 702459002160 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 702459002161 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 702459002162 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459002163 ATP binding site [chemical binding]; other site 702459002164 putative Mg++ binding site [ion binding]; other site 702459002165 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459002166 nucleotide binding region [chemical binding]; other site 702459002167 ATP-binding site [chemical binding]; other site 702459002168 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 702459002169 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 702459002170 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 702459002171 chorismate binding enzyme; Region: Chorismate_bind; cl10555 702459002172 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 702459002173 homodimer interface [polypeptide binding]; other site 702459002174 substrate-cofactor binding pocket; other site 702459002175 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459002176 catalytic residue [active] 702459002177 enolase; Provisional; Region: eno; PRK00077 702459002178 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 702459002179 dimer interface [polypeptide binding]; other site 702459002180 metal binding site [ion binding]; metal-binding site 702459002181 substrate binding pocket [chemical binding]; other site 702459002182 Septum formation initiator; Region: DivIC; pfam04977 702459002183 Protein of unknown function (DUF501); Region: DUF501; pfam04417 702459002184 Ppx/GppA phosphatase family; Region: Ppx-GppA; cl19483 702459002185 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 702459002186 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 702459002187 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 702459002188 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 702459002189 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 702459002190 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 702459002191 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 702459002192 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 702459002193 core domain of the SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like; cl19107 702459002194 Haemolysin-III related; Region: HlyIII; pfam03006 702459002195 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 702459002196 PAS fold; Region: PAS_4; pfam08448 702459002197 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 702459002198 Histidine kinase; Region: HisKA_2; pfam07568 702459002199 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459002200 ATP binding site [chemical binding]; other site 702459002201 Mg2+ binding site [ion binding]; other site 702459002202 G-X-G motif; other site 702459002203 Transcription factor WhiB; Region: Whib; pfam02467 702459002204 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 702459002205 Transcriptional regulator [Transcription]; Region: LytR; COG1316 702459002206 Transcription factor WhiB; Region: Whib; pfam02467 702459002207 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 702459002208 active site 702459002209 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 702459002210 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 702459002211 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 702459002212 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 702459002213 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459002214 active site 702459002215 motif I; other site 702459002216 motif II; other site 702459002217 Eukaryotic phosphomannomutase; Region: PMM; cl17107 702459002218 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 702459002219 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459002220 active site 702459002221 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 702459002222 Catalytic site [active] 702459002223 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 702459002224 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 702459002225 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 702459002226 dimerization interface [polypeptide binding]; other site 702459002227 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 702459002228 dimer interface [polypeptide binding]; other site 702459002229 phosphorylation site [posttranslational modification] 702459002230 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459002231 ATP binding site [chemical binding]; other site 702459002232 Mg2+ binding site [ion binding]; other site 702459002233 G-X-G motif; other site 702459002234 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 702459002235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459002236 active site 702459002237 phosphorylation site [posttranslational modification] 702459002238 intermolecular recognition site; other site 702459002239 dimerization interface [polypeptide binding]; other site 702459002240 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 702459002241 DNA binding site [nucleotide binding] 702459002242 glycogen branching enzyme; Provisional; Region: PRK05402 702459002243 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 702459002244 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 702459002245 active site 702459002246 catalytic site [active] 702459002247 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 702459002248 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 702459002249 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 702459002250 homotrimer interaction site [polypeptide binding]; other site 702459002251 zinc binding site [ion binding]; other site 702459002252 CDP-binding sites; other site 702459002253 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 702459002254 ABC-ATPase subunit interface; other site 702459002255 dimer interface [polypeptide binding]; other site 702459002256 putative PBP binding regions; other site 702459002257 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 702459002258 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 702459002259 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 702459002260 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 702459002261 intersubunit interface [polypeptide binding]; other site 702459002262 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 702459002263 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 702459002264 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 702459002265 homodimer interface [polypeptide binding]; other site 702459002266 NADP binding site [chemical binding]; other site 702459002267 substrate binding site [chemical binding]; other site 702459002268 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 702459002269 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 702459002270 RNA binding site [nucleotide binding]; other site 702459002271 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 702459002272 RNA binding site [nucleotide binding]; other site 702459002273 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 702459002274 RNA binding site [nucleotide binding]; other site 702459002275 S1 RNA binding domain; Region: S1; pfam00575 702459002276 RNA binding site [nucleotide binding]; other site 702459002277 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 702459002278 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 702459002279 CoA-binding site [chemical binding]; other site 702459002280 ATP-binding [chemical binding]; other site 702459002281 excinuclease ABC subunit B; Provisional; Region: PRK05298 702459002282 Bifunctional transglycosylase second domain; Region: UB2H; pfam14814 702459002283 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459002284 nucleotide binding region [chemical binding]; other site 702459002285 ATP-binding site [chemical binding]; other site 702459002286 Ultra-violet resistance protein B; Region: UvrB; pfam12344 702459002287 UvrB/uvrC motif; Region: UVR; pfam02151 702459002288 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 702459002289 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 702459002290 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 702459002291 domain interfaces; other site 702459002292 active site 702459002293 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 702459002294 dimer interface [polypeptide binding]; other site 702459002295 ADP-ribose binding site [chemical binding]; other site 702459002296 active site 702459002297 nudix motif; other site 702459002298 metal binding site [ion binding]; metal-binding site 702459002299 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 702459002300 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459002301 active site 702459002302 phosphorylation site [posttranslational modification] 702459002303 intermolecular recognition site; other site 702459002304 dimerization interface [polypeptide binding]; other site 702459002305 ANTAR domain; Region: ANTAR; pfam03861 702459002306 DNA polymerase I; Provisional; Region: PRK05755 702459002307 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 702459002308 active site 702459002309 metal binding site 1 [ion binding]; metal-binding site 702459002310 putative 5' ssDNA interaction site; other site 702459002311 metal binding site 3; metal-binding site 702459002312 metal binding site 2 [ion binding]; metal-binding site 702459002313 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 702459002314 putative DNA binding site [nucleotide binding]; other site 702459002315 putative metal binding site [ion binding]; other site 702459002316 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 702459002317 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 702459002318 active site 702459002319 DNA binding site [nucleotide binding] 702459002320 catalytic site [active] 702459002321 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 702459002322 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 702459002323 dimer interface [polypeptide binding]; other site 702459002324 ADP-ribose binding site [chemical binding]; other site 702459002325 active site 702459002326 nudix motif; other site 702459002327 metal binding site [ion binding]; metal-binding site 702459002328 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 702459002329 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 702459002330 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 702459002331 active site 702459002332 catalytic site [active] 702459002333 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 702459002334 active site 702459002335 DNA binding site [nucleotide binding] 702459002336 Int/Topo IB signature motif; other site 702459002337 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 702459002338 conserved cys residue [active] 702459002339 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 702459002340 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 702459002341 hinge; other site 702459002342 active site 702459002343 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 702459002344 BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857 702459002345 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 702459002346 hypothetical protein; Provisional; Region: PRK13663 702459002347 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 702459002348 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 702459002349 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 702459002350 GMP synthase; Reviewed; Region: guaA; PRK00074 702459002351 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 702459002352 AMP/PPi binding site [chemical binding]; other site 702459002353 candidate oxyanion hole; other site 702459002354 catalytic triad [active] 702459002355 potential glutamine specificity residues [chemical binding]; other site 702459002356 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 702459002357 ATP Binding subdomain [chemical binding]; other site 702459002358 Ligand Binding sites [chemical binding]; other site 702459002359 Dimerization subdomain; other site 702459002360 putative phosphoketolase; Provisional; Region: PRK05261 702459002361 XFP N-terminal domain; Region: XFP_N; pfam09364 702459002362 D-xylulose 5-phosphate/D-fructose 6-phosphate phosphoketolase; Region: XFP; pfam03894 702459002363 XFP C-terminal domain; Region: XFP_C; pfam09363 702459002364 Phosphate transporter family; Region: PHO4; pfam01384 702459002365 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 702459002366 TIGR00153 family protein; Region: TIGR00153 702459002367 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 702459002368 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459002369 active site 702459002370 phosphorylation site [posttranslational modification] 702459002371 intermolecular recognition site; other site 702459002372 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 702459002373 DNA binding residues [nucleotide binding] 702459002374 dimerization interface [polypeptide binding]; other site 702459002375 Histidine kinase; Region: HisKA_3; pfam07730 702459002376 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459002377 ATP binding site [chemical binding]; other site 702459002378 Mg2+ binding site [ion binding]; other site 702459002379 G-X-G motif; other site 702459002380 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 702459002381 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459002382 Walker A/P-loop; other site 702459002383 ATP binding site [chemical binding]; other site 702459002384 Q-loop/lid; other site 702459002385 ABC transporter signature motif; other site 702459002386 Walker B; other site 702459002387 D-loop; other site 702459002388 H-loop/switch region; other site 702459002389 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 702459002390 ABC-2 type transporter; Region: ABC2_membrane; cl17235 702459002391 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 702459002392 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 702459002393 Divergent AAA domain; Region: AAA_4; pfam04326 702459002394 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 702459002395 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 702459002396 Helix-turn-helix domain; Region: HTH_38; pfam13936 702459002397 Integrase core domain; Region: rve; pfam00665 702459002398 MobA/MobL family; Region: MobA_MobL; pfam03389 702459002399 Transposase; Region: HTH_Tnp_1; cl17663 702459002400 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 702459002401 putative transposase OrfB; Reviewed; Region: PHA02517 702459002402 HTH-like domain; Region: HTH_21; pfam13276 702459002403 Integrase core domain; Region: rve; pfam00665 702459002404 Integrase core domain; Region: rve_3; pfam13683 702459002405 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 702459002406 catalytic triad [active] 702459002407 conserved cis-peptide bond; other site 702459002408 potential frameshift: common BLAST hit: gi|296453675|ref|YP_003660818.1| glucosamine--fructose-6-phosphate aminotransferase 702459002409 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 702459002410 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 702459002411 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 702459002412 Sulfate transporter family; Region: Sulfate_transp; cl19250 702459002413 xanthine permease; Region: pbuX; TIGR03173 702459002414 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459002415 active site 702459002416 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 702459002417 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 702459002418 active site 702459002419 catalytic triad [active] 702459002420 oxyanion hole [active] 702459002421 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 702459002422 Part of AAA domain; Region: AAA_19; pfam13245 702459002423 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; pfam13538 702459002424 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 702459002425 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 702459002426 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 702459002427 FtsX-like permease family; Region: FtsX; pfam02687 702459002428 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 702459002429 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 702459002430 Walker A/P-loop; other site 702459002431 ATP binding site [chemical binding]; other site 702459002432 Q-loop/lid; other site 702459002433 ABC transporter signature motif; other site 702459002434 Walker B; other site 702459002435 D-loop; other site 702459002436 H-loop/switch region; other site 702459002437 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 702459002438 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 702459002439 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 702459002440 RNA binding surface [nucleotide binding]; other site 702459002441 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 702459002442 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 702459002443 catalytic triad [active] 702459002444 catalytic triad [active] 702459002445 oxyanion hole [active] 702459002446 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 702459002447 catalytic core [active] 702459002448 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 702459002449 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 702459002450 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 702459002451 motif 1; other site 702459002452 active site 702459002453 motif 2; other site 702459002454 motif 3; other site 702459002455 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; cl08469 702459002456 DHHA1 domain; Region: DHHA1; pfam02272 702459002457 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 702459002458 YceG-like family; Region: YceG; pfam02618 702459002459 dimerization interface [polypeptide binding]; other site 702459002460 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 702459002461 Tetramer interface [polypeptide binding]; other site 702459002462 active site 702459002463 FMN-binding site [chemical binding]; other site 702459002464 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 702459002465 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 702459002466 ADP binding site [chemical binding]; other site 702459002467 magnesium binding site [ion binding]; other site 702459002468 putative shikimate binding site; other site 702459002469 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 702459002470 active site 702459002471 dimer interface [polypeptide binding]; other site 702459002472 metal binding site [ion binding]; metal-binding site 702459002473 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 702459002474 trimer interface [polypeptide binding]; other site 702459002475 active site 702459002476 dimer interface [polypeptide binding]; other site 702459002477 DNA translocase FtsK; Provisional; Region: PRK10263 702459002478 Domain of unknown function (DUF4515); Region: DUF4515; pfam14988 702459002479 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 702459002480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459002481 active site 702459002482 phosphorylation site [posttranslational modification] 702459002483 intermolecular recognition site; other site 702459002484 dimerization interface [polypeptide binding]; other site 702459002485 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 702459002486 DNA binding residues [nucleotide binding] 702459002487 dimerization interface [polypeptide binding]; other site 702459002488 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 702459002489 CTP synthetase; Validated; Region: pyrG; PRK05380 702459002490 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 702459002491 Catalytic site [active] 702459002492 active site 702459002493 UTP binding site [chemical binding]; other site 702459002494 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 702459002495 active site 702459002496 putative oxyanion hole; other site 702459002497 catalytic triad [active] 702459002498 FeS assembly protein SufB; Region: sufB; TIGR01980 702459002499 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 702459002500 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 702459002501 FeS assembly protein SufD; Region: sufD; TIGR01981 702459002502 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 702459002503 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 702459002504 Walker A/P-loop; other site 702459002505 ATP binding site [chemical binding]; other site 702459002506 Q-loop/lid; other site 702459002507 ABC transporter signature motif; other site 702459002508 Walker B; other site 702459002509 D-loop; other site 702459002510 H-loop/switch region; other site 702459002511 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 702459002512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 702459002513 catalytic residue [active] 702459002514 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 702459002515 trimerization site [polypeptide binding]; other site 702459002516 active site 702459002517 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 702459002518 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 702459002519 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 702459002520 ligand binding site; other site 702459002521 oligomer interface; other site 702459002522 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 702459002523 dimer interface [polypeptide binding]; other site 702459002524 N-terminal domain interface [polypeptide binding]; other site 702459002525 sulfate 1 binding site; other site 702459002526 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 702459002527 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 702459002528 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 702459002529 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 702459002530 nucleotide binding site/active site [active] 702459002531 HIT family signature motif; other site 702459002532 catalytic residue [active] 702459002533 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 702459002534 PhoH-like protein; Region: PhoH; pfam02562 702459002535 metal-binding heat shock protein; Provisional; Region: PRK00016 702459002536 FOG: CBS domain [General function prediction only]; Region: COG0517 702459002537 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 702459002538 Transporter associated domain; Region: CorC_HlyC; smart01091 702459002539 GTPase Era; Reviewed; Region: era; PRK00089 702459002540 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 702459002541 G1 box; other site 702459002542 GTP/Mg2+ binding site [chemical binding]; other site 702459002543 Switch I region; other site 702459002544 G2 box; other site 702459002545 Switch II region; other site 702459002546 G3 box; other site 702459002547 G4 box; other site 702459002548 G5 box; other site 702459002549 KH domain; Region: KH_2; pfam07650 702459002550 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 702459002551 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 702459002552 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 702459002553 acyl-activating enzyme (AAE) consensus motif; other site 702459002554 putative AMP binding site [chemical binding]; other site 702459002555 putative active site [active] 702459002556 putative CoA binding site [chemical binding]; other site 702459002557 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 702459002558 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 702459002559 ligand binding site [chemical binding]; other site 702459002560 homodimer interface [polypeptide binding]; other site 702459002561 NAD(P) binding site [chemical binding]; other site 702459002562 trimer interface B [polypeptide binding]; other site 702459002563 trimer interface A [polypeptide binding]; other site 702459002564 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 702459002565 NAD(P) transhydrogenase beta subunit; Region: PNTB; cl00566 702459002566 Putative lysophospholipase; Region: Hydrolase_4; cl19140 702459002567 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 702459002568 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 702459002569 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 702459002570 5S rRNA interface [nucleotide binding]; other site 702459002571 CTC domain interface [polypeptide binding]; other site 702459002572 L16 interface [polypeptide binding]; other site 702459002573 Ribosomal protein TL5, C-terminal domain; Region: Ribosomal_TL5_C; pfam14693 702459002574 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 702459002575 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 702459002576 homodimer interface [polypeptide binding]; other site 702459002577 substrate-cofactor binding pocket; other site 702459002578 catalytic residue [active] 702459002579 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 702459002580 active site 702459002581 metal binding site [ion binding]; metal-binding site 702459002582 AAA domain; Region: AAA_17; cl19128 702459002583 UPF0126 domain; Region: UPF0126; pfam03458 702459002584 UPF0126 domain; Region: UPF0126; pfam03458 702459002585 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 702459002586 GTP-binding protein LepA; Provisional; Region: PRK05433 702459002587 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 702459002588 G1 box; other site 702459002589 putative GEF interaction site [polypeptide binding]; other site 702459002590 GTP/Mg2+ binding site [chemical binding]; other site 702459002591 Switch I region; other site 702459002592 G2 box; other site 702459002593 G3 box; other site 702459002594 Switch II region; other site 702459002595 G4 box; other site 702459002596 G5 box; other site 702459002597 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 702459002598 Elongation Factor G, domain II; Region: EFG_II; pfam14492 702459002599 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 702459002600 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 702459002601 coproporphyrinogen III oxidase; Validated; Region: PRK05628 702459002602 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 702459002603 FeS/SAM binding site; other site 702459002604 HemN C-terminal domain; Region: HemN_C; pfam06969 702459002605 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 702459002606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459002607 non-specific DNA binding site [nucleotide binding]; other site 702459002608 salt bridge; other site 702459002609 sequence-specific DNA binding site [nucleotide binding]; other site 702459002610 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459002611 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459002612 homodimer interface [polypeptide binding]; other site 702459002613 catalytic residue [active] 702459002614 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 702459002615 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 702459002616 G1 box; other site 702459002617 GTP/Mg2+ binding site [chemical binding]; other site 702459002618 G2 box; other site 702459002619 Switch I region; other site 702459002620 G3 box; other site 702459002621 Switch II region; other site 702459002622 G4 box; other site 702459002623 G5 box; other site 702459002624 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 702459002625 Elongation Factor G, domain II; Region: EFG_II; pfam14492 702459002626 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 702459002627 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 702459002628 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 702459002629 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 702459002630 active site 702459002631 dimer interface [polypeptide binding]; other site 702459002632 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 702459002633 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 702459002634 active site 702459002635 FMN binding site [chemical binding]; other site 702459002636 substrate binding site [chemical binding]; other site 702459002637 3Fe-4S cluster binding site [ion binding]; other site 702459002638 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 702459002639 domain interface; other site 702459002640 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 702459002641 Dihydroprymidine dehydrogenase domain II, 4Fe-4S cluster; Region: Fer4_20; pfam14691 702459002642 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 702459002643 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 702459002644 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 702459002645 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 702459002646 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 702459002647 Walker A/P-loop; other site 702459002648 ATP binding site [chemical binding]; other site 702459002649 Q-loop/lid; other site 702459002650 ABC transporter signature motif; other site 702459002651 Walker B; other site 702459002652 D-loop; other site 702459002653 H-loop/switch region; other site 702459002654 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 702459002655 putative active site [active] 702459002656 catalytic triad [active] 702459002657 putative dimer interface [polypeptide binding]; other site 702459002658 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 702459002659 Sel1-like repeats; Region: SEL1; smart00671 702459002660 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 702459002661 active site 702459002662 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 702459002663 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 702459002664 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 702459002665 Transposase; Region: DDE_Tnp_ISL3; pfam01610 702459002666 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459002667 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 702459002668 non-specific DNA binding site [nucleotide binding]; other site 702459002669 salt bridge; other site 702459002670 sequence-specific DNA binding site [nucleotide binding]; other site 702459002671 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 702459002672 TIR domain; Region: TIR_2; cl17458 702459002673 T5orf172 domain; Region: T5orf172; pfam10544 702459002674 DEAD-like helicases superfamily; Region: DEXDc; smart00487 702459002675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 702459002676 potential frameshift: common BLAST hit: gi|21673986|ref|NP_662051.1| type III restriction system endonuclease 702459002677 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 702459002678 Protein of unknown function DUF262; Region: DUF262; pfam03235 702459002679 Uncharacterized conserved protein [Function unknown]; Region: COG1479 702459002680 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 702459002681 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 702459002682 Domain of unknown function (DUF4268); Region: DUF4268; pfam14088 702459002683 Predicted permeases [General function prediction only]; Region: RarD; COG2962 702459002684 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 702459002685 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 702459002686 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 702459002687 tRNA methyltransferase complex GCD14 subunit N-term; Region: GCD14_N; pfam14801 702459002688 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 702459002689 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459002690 S-adenosylmethionine binding site [chemical binding]; other site 702459002691 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 702459002692 catalytic core [active] 702459002693 Bbif-1 prophage element 702459002694 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 702459002695 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 702459002696 active site 702459002697 DNA binding site [nucleotide binding] 702459002698 Int/Topo IB signature motif; other site 702459002699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 702459002700 metal ion transporter CorA-like divalent cation transporter superfamily; Region: MIT_CorA-like; cl00459 702459002701 Domain of unknown function (DUF955); Region: DUF955; cl01076 702459002702 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 702459002703 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 702459002704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459002705 non-specific DNA binding site [nucleotide binding]; other site 702459002706 salt bridge; other site 702459002707 sequence-specific DNA binding site [nucleotide binding]; other site 702459002708 BRO family, N-terminal domain; Region: Bro-N; smart01040 702459002709 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 702459002710 Helix-turn-helix domain; Region: HTH_17; pfam12728 702459002711 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 702459002712 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 702459002713 dimer interface [polypeptide binding]; other site 702459002714 ssDNA binding site [nucleotide binding]; other site 702459002715 tetramer (dimer of dimers) interface [polypeptide binding]; other site 702459002716 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 702459002717 ParB-like nuclease domain; Region: ParB; smart00470 702459002718 Helix-turn-helix domain; Region: HTH_36; pfam13730 702459002719 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 702459002720 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 702459002721 active site 702459002722 catalytic site [active] 702459002723 substrate binding site [chemical binding]; other site 702459002724 Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354 702459002725 YcfA-like protein; Region: YcfA; cl00752 702459002726 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 702459002727 Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681 702459002728 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 702459002729 active site 702459002730 AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287 702459002731 Phage terminase, small subunit; Region: Terminase_4; cl01525 702459002732 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 702459002733 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 702459002734 Phage capsid family; Region: Phage_capsid; pfam05065 702459002735 Head fiber protein; Region: Phage_head_fibr; pfam11133 702459002736 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cl19050 702459002737 Phage tail protein; Region: Sipho_tail; cl17486 702459002738 Prophage endopeptidase tail; Region: Prophage_tail; cl19379 702459002739 Phage lysis protein, holin; Region: Phage_holin; pfam04688 702459002740 Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409 702459002741 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 702459002742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459002743 salt bridge; other site 702459002744 non-specific DNA binding site [nucleotide binding]; other site 702459002745 sequence-specific DNA binding site [nucleotide binding]; other site 702459002746 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 702459002747 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 702459002748 THF binding site; other site 702459002749 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 702459002750 substrate binding site [chemical binding]; other site 702459002751 THF binding site; other site 702459002752 zinc-binding site [ion binding]; other site 702459002753 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 702459002754 FAD binding site [chemical binding]; other site 702459002755 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 702459002756 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 702459002757 metal binding triad; other site 702459002758 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 702459002759 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 702459002760 metal binding triad; other site 702459002761 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; cl19627 702459002762 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 702459002763 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 702459002764 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 702459002765 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 702459002766 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 702459002767 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 702459002768 dihydroorotase; Validated; Region: pyrC; PRK09357 702459002769 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 702459002770 active site 702459002771 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 702459002772 active site 702459002773 dimer interface [polypeptide binding]; other site 702459002774 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 702459002775 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 702459002776 FAD binding pocket [chemical binding]; other site 702459002777 FAD binding motif [chemical binding]; other site 702459002778 phosphate binding motif [ion binding]; other site 702459002779 beta-alpha-beta structure motif; other site 702459002780 NAD binding pocket [chemical binding]; other site 702459002781 Iron coordination center [ion binding]; other site 702459002782 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 702459002783 heterodimer interface [polypeptide binding]; other site 702459002784 active site 702459002785 FMN binding site [chemical binding]; other site 702459002786 homodimer interface [polypeptide binding]; other site 702459002787 substrate binding site [chemical binding]; other site 702459002788 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459002789 active site 702459002790 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 702459002791 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 702459002792 DNA binding residues [nucleotide binding] 702459002793 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 702459002794 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 702459002795 catalytic Zn binding site [ion binding]; other site 702459002796 NAD(P) binding site [chemical binding]; other site 702459002797 structural Zn binding site [ion binding]; other site 702459002798 Beta-carotene 15,15'-dioxygenase; Region: BCD; cl14026 702459002799 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 702459002800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459002801 Walker A/P-loop; other site 702459002802 ATP binding site [chemical binding]; other site 702459002803 Q-loop/lid; other site 702459002804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459002805 ABC transporter signature motif; other site 702459002806 Walker B; other site 702459002807 D-loop; other site 702459002808 H-loop/switch region; other site 702459002809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459002810 Walker A/P-loop; other site 702459002811 ATP binding site [chemical binding]; other site 702459002812 Q-loop/lid; other site 702459002813 ABC transporter signature motif; other site 702459002814 Walker B; other site 702459002815 D-loop; other site 702459002816 H-loop/switch region; other site 702459002817 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 702459002818 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 702459002819 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 702459002820 classical (c) SDRs; Region: SDR_c; cd05233 702459002821 NAD(P) binding site [chemical binding]; other site 702459002822 active site 702459002823 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 702459002824 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 702459002825 minor groove reading motif; other site 702459002826 helix-hairpin-helix signature motif; other site 702459002827 substrate binding pocket [chemical binding]; other site 702459002828 active site 702459002829 Predicted transcriptional regulators [Transcription]; Region: COG1695 702459002830 Membrane transport protein; Region: Mem_trans; cl09117 702459002831 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 702459002832 HipA N-terminal domain; Region: Couple_hipA; pfam13657 702459002833 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 702459002834 HipA-like N-terminal domain; Region: HipA_N; pfam07805 702459002835 HipA-like C-terminal domain; Region: HipA_C; pfam07804 702459002836 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 702459002837 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459002838 salt bridge; other site 702459002839 non-specific DNA binding site [nucleotide binding]; other site 702459002840 sequence-specific DNA binding site [nucleotide binding]; other site 702459002841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459002842 S-adenosylmethionine binding site [chemical binding]; other site 702459002843 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 702459002844 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 702459002845 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 702459002846 Transcriptional regulator [Transcription]; Region: LysR; COG0583 702459002847 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 702459002848 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 702459002849 dimerization interface [polypeptide binding]; other site 702459002850 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 702459002851 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 702459002852 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459002853 motif II; other site 702459002854 putative carbohydrate kinase; Provisional; Region: PRK10565 702459002855 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 702459002856 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 702459002857 putative substrate binding site [chemical binding]; other site 702459002858 putative ATP binding site [chemical binding]; other site 702459002859 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 702459002860 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 702459002861 potential frameshift: common BLAST hit: gi|296454739|ref|YP_003661882.1| 2,5-didehydrogluconate reductase 702459002862 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 702459002863 Aldo/keto reductases, related to diketogulonate reductase [General function prediction only]; Region: ARA1; COG0656 702459002864 catalytic tetrad [active] 702459002865 Domain of unknown function (DUF4263); Region: DUF4263; pfam14082 702459002866 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 702459002867 active site 702459002868 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 702459002869 cofactor binding site; other site 702459002870 DNA binding site [nucleotide binding] 702459002871 substrate interaction site [chemical binding]; other site 702459002872 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 702459002873 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 702459002874 active site 702459002875 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 702459002876 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cl00425 702459002877 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 702459002878 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459002879 non-specific DNA binding site [nucleotide binding]; other site 702459002880 salt bridge; other site 702459002881 sequence-specific DNA binding site [nucleotide binding]; other site 702459002882 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 702459002883 active site 702459002884 Predicted transcriptional regulator [Transcription]; Region: COG2378 702459002885 WYL domain; Region: WYL; pfam13280 702459002886 DEAD-like helicases superfamily; Region: DEXDc; smart00487 702459002887 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459002888 ATP binding site [chemical binding]; other site 702459002889 putative Mg++ binding site [ion binding]; other site 702459002890 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459002891 nucleotide binding region [chemical binding]; other site 702459002892 ATP-binding site [chemical binding]; other site 702459002893 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 702459002894 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 702459002895 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 702459002896 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459002897 motif II; other site 702459002898 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 702459002899 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 702459002900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459002901 non-specific DNA binding site [nucleotide binding]; other site 702459002902 salt bridge; other site 702459002903 sequence-specific DNA binding site [nucleotide binding]; other site 702459002904 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 702459002905 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 702459002906 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 702459002907 DNA binding residues [nucleotide binding] 702459002908 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 702459002909 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 702459002910 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 702459002911 phosphopeptide binding site; other site 702459002912 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 702459002913 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 702459002914 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 702459002915 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 702459002916 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 702459002917 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 702459002918 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 702459002919 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 702459002920 homodimer interface [polypeptide binding]; other site 702459002921 putative metal binding site [ion binding]; other site 702459002922 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 702459002923 substrate binding site [chemical binding]; other site 702459002924 hexamer interface [polypeptide binding]; other site 702459002925 metal binding site [ion binding]; metal-binding site 702459002926 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 702459002927 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 702459002928 substrate binding site [chemical binding]; other site 702459002929 active site 702459002930 catalytic residues [active] 702459002931 heterodimer interface [polypeptide binding]; other site 702459002932 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 702459002933 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 702459002934 active site 702459002935 ribulose/triose binding site [chemical binding]; other site 702459002936 phosphate binding site [ion binding]; other site 702459002937 substrate (anthranilate) binding pocket [chemical binding]; other site 702459002938 product (indole) binding pocket [chemical binding]; other site 702459002939 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 702459002940 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459002941 catalytic residue [active] 702459002942 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 702459002943 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 702459002944 CMP-binding site; other site 702459002945 The sites determining sugar specificity; other site 702459002946 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 702459002947 G4 box; other site 702459002948 GTP/Mg2+ binding site [chemical binding]; other site 702459002949 G5 box; other site 702459002950 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 702459002951 G1 box; other site 702459002952 G1 box; other site 702459002953 GTP/Mg2+ binding site [chemical binding]; other site 702459002954 Switch I region; other site 702459002955 Switch I region; other site 702459002956 G2 box; other site 702459002957 G2 box; other site 702459002958 Switch II region; other site 702459002959 G3 box; other site 702459002960 G4 box; other site 702459002961 G5 box; other site 702459002962 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 702459002963 G1 box; other site 702459002964 GTP/Mg2+ binding site [chemical binding]; other site 702459002965 Switch I region; other site 702459002966 G2 box; other site 702459002967 G3 box; other site 702459002968 Switch II region; other site 702459002969 G4 box; other site 702459002970 G5 box; other site 702459002971 KH-domain-like of EngA bacterial GTPase enzymes, C-terminal; Region: KH_dom-like; pfam14714 702459002972 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 702459002973 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 702459002974 RNA binding surface [nucleotide binding]; other site 702459002975 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 702459002976 active site 702459002977 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 702459002978 amphipathic channel; other site 702459002979 Asn-Pro-Ala signature motifs; other site 702459002980 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 702459002981 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 702459002982 purine monophosphate binding site [chemical binding]; other site 702459002983 dimer interface [polypeptide binding]; other site 702459002984 putative catalytic residues [active] 702459002985 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 702459002986 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 702459002987 CoA binding domain; Region: CoA_binding; pfam02629 702459002988 CoA-ligase; Region: Ligase_CoA; pfam00549 702459002989 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 702459002990 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 702459002991 CoA-ligase; Region: Ligase_CoA; pfam00549 702459002992 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459002993 active site 702459002994 Preprotein translocase subunit; Region: YajC; cl00806 702459002995 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 702459002996 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459002997 Walker A motif; other site 702459002998 ATP binding site [chemical binding]; other site 702459002999 Walker B motif; other site 702459003000 arginine finger; other site 702459003001 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 702459003002 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 702459003003 RuvA N terminal domain; Region: RuvA_N; pfam01330 702459003004 Helix-hairpin-helix domain; Region: HHH_5; pfam14520 702459003005 potential frameshift: common BLAST hit: gi|310287482|ref|YP_003938740.1| crossover junction endodeoxyribonuclease ruvC 702459003006 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cl17280 702459003007 active site 702459003008 putative DNA-binding cleft [nucleotide binding]; other site 702459003009 dimer interface [polypeptide binding]; other site 702459003010 hypothetical protein; Validated; Region: PRK00110 702459003011 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459003012 sugar binding site [chemical binding]; other site 702459003013 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; cl03741 702459003014 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 702459003015 active site 702459003016 Ubiquitin-like proteins; Region: UBQ; cl00155 702459003017 charged pocket; other site 702459003018 hydrophobic patch; other site 702459003019 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 702459003020 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 702459003021 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 702459003022 active site 702459003023 dimer interface [polypeptide binding]; other site 702459003024 motif 1; other site 702459003025 motif 2; other site 702459003026 motif 3; other site 702459003027 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 702459003028 anticodon binding site; other site 702459003029 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 702459003030 PAC2 family; Region: PAC2; pfam09754 702459003031 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 702459003032 Phosphotransferase enzyme family; Region: APH; pfam01636 702459003033 Fructosamine kinase; Region: Fructosamin_kin; cl17579 702459003034 chaperone protein DnaJ; Provisional; Region: PRK14278 702459003035 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 702459003036 HSP70 interaction site [polypeptide binding]; other site 702459003037 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 702459003038 Zn binding sites [ion binding]; other site 702459003039 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 702459003040 dimer interface [polypeptide binding]; other site 702459003041 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 702459003042 HTH domain; Region: HTH_11; pfam08279 702459003043 HrcA protein C terminal domain; Region: HrcA; pfam01628 702459003044 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 702459003045 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 702459003046 TPP-binding site [chemical binding]; other site 702459003047 dimer interface [polypeptide binding]; other site 702459003048 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 702459003049 PYR/PP interface [polypeptide binding]; other site 702459003050 dimer interface [polypeptide binding]; other site 702459003051 TPP binding site [chemical binding]; other site 702459003052 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 702459003053 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 702459003054 putative active site [active] 702459003055 catalytic residue [active] 702459003056 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 702459003057 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 702459003058 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 702459003059 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 702459003060 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459003061 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 702459003062 active site 702459003063 motif I; other site 702459003064 motif II; other site 702459003065 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 702459003066 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 702459003067 tetramer (dimer of dimers) interface [polypeptide binding]; other site 702459003068 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 702459003069 NAD binding site [chemical binding]; other site 702459003070 dimer interface [polypeptide binding]; other site 702459003071 substrate binding site [chemical binding]; other site 702459003072 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 702459003073 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 702459003074 substrate binding site [chemical binding]; other site 702459003075 dimer interface [polypeptide binding]; other site 702459003076 catalytic triad [active] 702459003077 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 702459003078 substrate binding site [chemical binding]; other site 702459003079 hinge regions; other site 702459003080 ADP binding site [chemical binding]; other site 702459003081 catalytic site [active] 702459003082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 702459003083 WhiA N-terminal LAGLIDADG-like domain; Region: WhiA_N; pfam10298 702459003084 WhiA LAGLIDADG-like domain; Region: LAGLIDADG_WhiA; pfam14527 702459003085 WhiA C-terminal HTH domain; Region: HTH_WhiA; pfam02650 702459003086 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 702459003087 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 702459003088 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 702459003089 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 702459003090 shikimate binding site; other site 702459003091 NAD(P) binding site [chemical binding]; other site 702459003092 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 702459003093 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 702459003094 GIY-YIG motif/motif A; other site 702459003095 active site 702459003096 catalytic site [active] 702459003097 putative DNA binding site [nucleotide binding]; other site 702459003098 metal binding site [ion binding]; metal-binding site 702459003099 UvrB/uvrC motif; Region: UVR; pfam02151 702459003100 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 702459003101 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 702459003102 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 702459003103 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 702459003104 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 702459003105 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 702459003106 FtsX-like permease family; Region: FtsX; pfam02687 702459003107 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 702459003108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459003109 active site 702459003110 phosphorylation site [posttranslational modification] 702459003111 intermolecular recognition site; other site 702459003112 dimerization interface [polypeptide binding]; other site 702459003113 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 702459003114 DNA binding site [nucleotide binding] 702459003115 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 702459003116 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 702459003117 dimerization interface [polypeptide binding]; other site 702459003118 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 702459003119 dimer interface [polypeptide binding]; other site 702459003120 phosphorylation site [posttranslational modification] 702459003121 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459003122 ATP binding site [chemical binding]; other site 702459003123 Mg2+ binding site [ion binding]; other site 702459003124 G-X-G motif; other site 702459003125 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 702459003126 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 702459003127 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 702459003128 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 702459003129 UDP-glucose 4-epimerase; Region: PLN02240 702459003130 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 702459003131 NAD binding site [chemical binding]; other site 702459003132 homodimer interface [polypeptide binding]; other site 702459003133 active site 702459003134 substrate binding site [chemical binding]; other site 702459003135 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 702459003136 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 702459003137 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 702459003138 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 702459003139 Phosphotransferase enzyme family; Region: APH; pfam01636 702459003140 active site 702459003141 substrate binding site [chemical binding]; other site 702459003142 ATP binding site [chemical binding]; other site 702459003143 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 702459003144 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 702459003145 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 702459003146 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 702459003147 nucleotide binding site [chemical binding]; other site 702459003148 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 702459003149 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 702459003150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459003151 dimer interface [polypeptide binding]; other site 702459003152 conserved gate region; other site 702459003153 putative PBP binding loops; other site 702459003154 ABC-ATPase subunit interface; other site 702459003155 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 702459003156 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459003157 dimer interface [polypeptide binding]; other site 702459003158 conserved gate region; other site 702459003159 ABC-ATPase subunit interface; other site 702459003160 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 702459003161 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 702459003162 anthranilate synthase component I; Provisional; Region: PRK13571 702459003163 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 702459003164 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 702459003165 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 702459003166 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 702459003167 substrate binding site [chemical binding]; other site 702459003168 glutamase interaction surface [polypeptide binding]; other site 702459003169 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 702459003170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 702459003171 FeS/SAM binding site; other site 702459003172 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 702459003173 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 702459003174 hinge region; other site 702459003175 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 702459003176 putative nucleotide binding site [chemical binding]; other site 702459003177 uridine monophosphate binding site [chemical binding]; other site 702459003178 homohexameric interface [polypeptide binding]; other site 702459003179 elongation factor Ts; Provisional; Region: tsf; PRK09377 702459003180 UBA/TS-N domain; Region: UBA; pfam00627 702459003181 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 702459003182 rRNA interaction site [nucleotide binding]; other site 702459003183 S8 interaction site; other site 702459003184 putative laminin-1 binding site; other site 702459003185 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 702459003186 active site 702459003187 catalytic residues [active] 702459003188 metal binding site [ion binding]; metal-binding site 702459003189 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 702459003190 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 702459003191 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 702459003192 acyl-activating enzyme (AAE) consensus motif; other site 702459003193 putative AMP binding site [chemical binding]; other site 702459003194 putative active site [active] 702459003195 putative CoA binding site [chemical binding]; other site 702459003196 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 702459003197 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 702459003198 active site 702459003199 isocitrate dehydrogenase; Validated; Region: PRK08299 702459003200 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 702459003201 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 702459003202 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 702459003203 acyl-activating enzyme (AAE) consensus motif; other site 702459003204 putative AMP binding site [chemical binding]; other site 702459003205 putative active site [active] 702459003206 putative CoA binding site [chemical binding]; other site 702459003207 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 702459003208 Peptidase family M23; Region: Peptidase_M23; pfam01551 702459003209 UGMP family protein; Validated; Region: PRK09604 702459003210 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 702459003211 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 702459003212 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 702459003213 Coenzyme A binding pocket [chemical binding]; other site 702459003214 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 702459003215 Glycoprotease family; Region: Peptidase_M22; pfam00814 702459003216 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 702459003217 hypothetical protein; Reviewed; Region: PRK07914 702459003218 Competence protein; Region: Competence; pfam03772 702459003219 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 702459003220 DNA uptake protein and related DNA-binding proteins [DNA replication, recombination, and repair]; Region: ComEA; COG1555 702459003221 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 702459003222 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 702459003223 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 702459003224 active site 702459003225 HIGH motif; other site 702459003226 nucleotide binding site [chemical binding]; other site 702459003227 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 702459003228 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 702459003229 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 702459003230 active site 702459003231 KMSKS motif; other site 702459003232 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 702459003233 tRNA binding surface [nucleotide binding]; other site 702459003234 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 702459003235 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 702459003236 substrate binding pocket [chemical binding]; other site 702459003237 membrane-bound complex binding site; other site 702459003238 hinge residues; other site 702459003239 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 702459003240 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 702459003241 Cl binding site [ion binding]; other site 702459003242 oligomer interface [polypeptide binding]; other site 702459003243 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 702459003244 catalytic core [active] 702459003245 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 702459003246 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 702459003247 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 702459003248 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 702459003249 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 702459003250 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 702459003251 Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648 702459003252 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 702459003253 AP (apurinic/apyrimidinic) site pocket; other site 702459003254 DNA interaction; other site 702459003255 Metal-binding active site; metal-binding site 702459003256 Uncharacterized conserved protein [Function unknown]; Region: COG3189 702459003257 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 702459003258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 702459003259 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 702459003260 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 702459003261 Coenzyme A binding pocket [chemical binding]; other site 702459003262 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 702459003263 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 702459003264 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 702459003265 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 702459003266 Coenzyme A binding pocket [chemical binding]; other site 702459003267 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 702459003268 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459003269 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 702459003270 G-X-G motif; other site 702459003271 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 702459003272 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 702459003273 potential frameshift: common BLAST hit: gi|296453972|ref|YP_003661115.1| major facilitator superfamily protein 702459003274 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459003275 Protein of unknown function (DUF1113); Region: DUF1113; cl19877 702459003276 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 702459003277 VanZ like family; Region: VanZ; cl01971 702459003278 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 702459003279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl19078 702459003280 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 702459003281 DNA binding site [nucleotide binding] 702459003282 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 702459003283 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 702459003284 Nitroreductase family; Region: Nitroreductase; pfam00881 702459003285 FMN binding site [chemical binding]; other site 702459003286 dimer interface [polypeptide binding]; other site 702459003287 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 702459003288 Alpha amylase, catalytic domain; Region: Alpha-amylase; pfam00128 702459003289 active site 702459003290 catalytic site [active] 702459003291 Bacterial PH domain; Region: bPH_2; pfam03703 702459003292 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 702459003293 catalytic core [active] 702459003294 Oligomerization domain; Region: Oligomerization; pfam02410 702459003295 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 702459003296 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 702459003297 Substrate binding site; other site 702459003298 Mg++ binding site; other site 702459003299 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 702459003300 active site 702459003301 substrate binding site [chemical binding]; other site 702459003302 CoA binding site [chemical binding]; other site 702459003303 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 702459003304 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 702459003305 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459003306 active site 702459003307 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 702459003308 active site 702459003309 (T/H)XGH motif; other site 702459003310 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 702459003311 putative catalytic cysteine [active] 702459003312 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 702459003313 threonine synthase; Validated; Region: PRK09225 702459003314 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459003315 catalytic residue [active] 702459003316 Acyltransferase family; Region: Acyl_transf_3; cl19154 702459003317 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 702459003318 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 702459003319 Walker A/P-loop; other site 702459003320 ATP binding site [chemical binding]; other site 702459003321 Q-loop/lid; other site 702459003322 ABC transporter signature motif; other site 702459003323 Walker B; other site 702459003324 D-loop; other site 702459003325 H-loop/switch region; other site 702459003326 Predicted transcriptional regulators [Transcription]; Region: COG1725 702459003327 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 702459003328 DNA-binding site [nucleotide binding]; DNA binding site 702459003329 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 702459003330 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 702459003331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459003332 motif II; other site 702459003333 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 702459003334 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 702459003335 Walker A/P-loop; other site 702459003336 ATP binding site [chemical binding]; other site 702459003337 Q-loop/lid; other site 702459003338 Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386 702459003339 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 702459003340 ABC transporter signature motif; other site 702459003341 Walker B; other site 702459003342 D-loop; other site 702459003343 H-loop/switch region; other site 702459003344 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 702459003345 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 702459003346 Cation transport protein; Region: TrkH; cl17365 702459003347 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 702459003348 TrkA-N domain; Region: TrkA_N; pfam02254 702459003349 TrkA-C domain; Region: TrkA_C; pfam02080 702459003350 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 702459003351 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 702459003352 RNA binding surface [nucleotide binding]; other site 702459003353 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459003354 S-adenosylmethionine binding site [chemical binding]; other site 702459003355 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 702459003356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459003357 active site 702459003358 motif I; other site 702459003359 motif II; other site 702459003360 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 702459003361 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 702459003362 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 702459003363 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 702459003364 active site 702459003365 HIGH motif; other site 702459003366 dimer interface [polypeptide binding]; other site 702459003367 KMSKS motif; other site 702459003368 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 702459003369 RNA binding surface [nucleotide binding]; other site 702459003370 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 702459003371 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 702459003372 Zn2+ binding site [ion binding]; other site 702459003373 Mg2+ binding site [ion binding]; other site 702459003374 argininosuccinate lyase; Provisional; Region: PRK00855 702459003375 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 702459003376 active sites [active] 702459003377 tetramer interface [polypeptide binding]; other site 702459003378 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 702459003379 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 702459003380 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459003381 ATP binding site [chemical binding]; other site 702459003382 putative Mg++ binding site [ion binding]; other site 702459003383 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 702459003384 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 702459003385 Divergent AAA domain; Region: AAA_4; pfam04326 702459003386 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 702459003387 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 702459003388 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 702459003389 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 702459003390 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 702459003391 HsdM N-terminal domain; Region: HsdM_N; pfam12161 702459003392 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 702459003393 Methyltransferase domain; Region: Methyltransf_26; pfam13659 702459003394 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 702459003395 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 702459003396 GIY-YIG motif/motif A; other site 702459003397 putative active site [active] 702459003398 putative metal binding site [ion binding]; other site 702459003399 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 702459003400 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 702459003401 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 702459003402 Int/Topo IB signature motif; other site 702459003403 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 702459003404 ANP binding site [chemical binding]; other site 702459003405 Substrate Binding Site II [chemical binding]; other site 702459003406 Substrate Binding Site I [chemical binding]; other site 702459003407 arginine repressor; Provisional; Region: PRK03341 702459003408 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 702459003409 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 702459003410 ornithine carbamoyltransferase; Provisional; Region: PRK00779 702459003411 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 702459003412 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 702459003413 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 702459003414 Adenosylmethionine-8-amino-7-oxononanoate aminotransferase [Coenzyme metabolism]; Region: BioA; COG0161 702459003415 inhibitor-cofactor binding pocket; inhibition site 702459003416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459003417 catalytic residue [active] 702459003418 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 702459003419 feedback inhibition sensing region; other site 702459003420 homohexameric interface [polypeptide binding]; other site 702459003421 nucleotide binding site [chemical binding]; other site 702459003422 N-acetyl-L-glutamate binding site [chemical binding]; other site 702459003423 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 702459003424 heterotetramer interface [polypeptide binding]; other site 702459003425 active site pocket [active] 702459003426 cleavage site 702459003427 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 702459003428 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; pfam01118 702459003429 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; cl19935 702459003430 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 702459003431 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 702459003432 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 702459003433 putative tRNA-binding site [nucleotide binding]; other site 702459003434 B3/4 domain; Region: B3_4; pfam03483 702459003435 tRNA synthetase B5 domain; Region: B5; smart00874 702459003436 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 702459003437 dimer interface [polypeptide binding]; other site 702459003438 motif 1; other site 702459003439 motif 3; other site 702459003440 motif 2; other site 702459003441 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 702459003442 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 702459003443 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 702459003444 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 702459003445 dimer interface [polypeptide binding]; other site 702459003446 motif 1; other site 702459003447 active site 702459003448 motif 2; other site 702459003449 motif 3; other site 702459003450 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 702459003451 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 702459003452 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 702459003453 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459003454 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 702459003455 Walker A/P-loop; other site 702459003456 ATP binding site [chemical binding]; other site 702459003457 Q-loop/lid; other site 702459003458 ABC transporter signature motif; other site 702459003459 Walker B; other site 702459003460 D-loop; other site 702459003461 H-loop/switch region; other site 702459003462 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 702459003463 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 702459003464 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 702459003465 Sulfate transporter family; Region: Sulfate_transp; cl19250 702459003466 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 702459003467 catalytic core [active] 702459003468 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 702459003469 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 702459003470 Transcriptional regulator [Transcription]; Region: LysR; COG0583 702459003471 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 702459003472 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 702459003473 dimerization interface [polypeptide binding]; other site 702459003474 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 702459003475 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 702459003476 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 702459003477 active site 702459003478 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 702459003479 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 702459003480 Double zinc ribbon; Region: DZR; pfam12773 702459003481 PASTA domain; Region: PASTA; pfam03793 702459003482 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 702459003483 lipoyl-biotinyl attachment site [posttranslational modification]; other site 702459003484 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 702459003485 Predicted esterase [General function prediction only]; Region: COG0400 702459003486 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 702459003487 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 702459003488 active site 702459003489 catalytic residues [active] 702459003490 metal binding site [ion binding]; metal-binding site 702459003491 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 702459003492 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; cl01381 702459003493 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 702459003494 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u1; cd03408 702459003495 Short C-terminal domain; Region: SHOCT; pfam09851 702459003496 Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477 702459003497 Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918 702459003498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459003499 non-specific DNA binding site [nucleotide binding]; other site 702459003500 salt bridge; other site 702459003501 sequence-specific DNA binding site [nucleotide binding]; other site 702459003502 Protein kinase domain; Region: Pkinase; pfam00069 702459003503 Catalytic domain of Protein Kinases; Region: PKc; cd00180 702459003504 active site 702459003505 ATP binding site [chemical binding]; other site 702459003506 substrate binding site [chemical binding]; other site 702459003507 activation loop (A-loop); other site 702459003508 Cupin domain; Region: Cupin_2; cl17218 702459003509 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459003510 S-adenosylmethionine binding site [chemical binding]; other site 702459003511 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 702459003512 hypothetical protein; Provisional; Region: PRK11770 702459003513 Domain of unknown function (DUF307); Region: DUF307; pfam03733 702459003514 Domain of unknown function (DUF307); Region: DUF307; pfam03733 702459003515 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 702459003516 Fic family protein [Function unknown]; Region: COG3177 702459003517 Fic/DOC family; Region: Fic; pfam02661 702459003518 GTP-binding protein YchF; Reviewed; Region: PRK09601 702459003519 YchF GTPase; Region: YchF; cd01900 702459003520 G1 box; other site 702459003521 GTP/Mg2+ binding site [chemical binding]; other site 702459003522 Switch I region; other site 702459003523 G2 box; other site 702459003524 Switch II region; other site 702459003525 G3 box; other site 702459003526 G4 box; other site 702459003527 G5 box; other site 702459003528 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 702459003529 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 702459003530 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459003531 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459003532 homodimer interface [polypeptide binding]; other site 702459003533 catalytic residue [active] 702459003534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459003535 dimer interface [polypeptide binding]; other site 702459003536 conserved gate region; other site 702459003537 putative PBP binding loops; other site 702459003538 ABC-ATPase subunit interface; other site 702459003539 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 702459003540 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 702459003541 Walker A/P-loop; other site 702459003542 ATP binding site [chemical binding]; other site 702459003543 Q-loop/lid; other site 702459003544 ABC transporter signature motif; other site 702459003545 Walker B; other site 702459003546 D-loop; other site 702459003547 H-loop/switch region; other site 702459003548 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 702459003549 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 702459003550 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 702459003551 PYR/PP interface [polypeptide binding]; other site 702459003552 dimer interface [polypeptide binding]; other site 702459003553 TPP binding site [chemical binding]; other site 702459003554 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 702459003555 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 702459003556 tetramer interface [polypeptide binding]; other site 702459003557 TPP-binding site [chemical binding]; other site 702459003558 heterodimer interface [polypeptide binding]; other site 702459003559 phosphorylation loop region [posttranslational modification] 702459003560 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 702459003561 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 702459003562 catalytic nucleophile [active] 702459003563 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 702459003564 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 702459003565 Pyrroline-5-carboxylate reductase dimerization; Region: P5CR_dimer; pfam14748 702459003566 Putative lysophospholipase; Region: Hydrolase_4; cl19140 702459003567 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 702459003568 Histidine kinase; Region: HisKA_3; pfam07730 702459003569 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459003570 ATP binding site [chemical binding]; other site 702459003571 Mg2+ binding site [ion binding]; other site 702459003572 G-X-G motif; other site 702459003573 Histidine kinase; Region: HisKA_3; pfam07730 702459003574 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 702459003575 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459003576 active site 702459003577 phosphorylation site [posttranslational modification] 702459003578 intermolecular recognition site; other site 702459003579 dimerization interface [polypeptide binding]; other site 702459003580 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 702459003581 DNA binding residues [nucleotide binding] 702459003582 dimerization interface [polypeptide binding]; other site 702459003583 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 702459003584 active site 702459003585 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 702459003586 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 702459003587 active site 702459003588 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 702459003589 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459003590 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 702459003591 FtsX-like permease family; Region: FtsX; pfam02687 702459003592 FtsX-like permease family; Region: FtsX; pfam02687 702459003593 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 702459003594 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 702459003595 Walker A/P-loop; other site 702459003596 ATP binding site [chemical binding]; other site 702459003597 Q-loop/lid; other site 702459003598 ABC transporter signature motif; other site 702459003599 Walker B; other site 702459003600 D-loop; other site 702459003601 H-loop/switch region; other site 702459003602 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 702459003603 homodimer interface [polypeptide binding]; other site 702459003604 substrate-cofactor binding pocket; other site 702459003605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459003606 catalytic residue [active] 702459003607 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 702459003608 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 702459003609 dimer interface [polypeptide binding]; other site 702459003610 pyridoxal binding site [chemical binding]; other site 702459003611 ATP binding site [chemical binding]; other site 702459003612 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 702459003613 L-aspartate oxidase; Provisional; Region: PRK06175 702459003614 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 702459003615 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 702459003616 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 702459003617 active site 702459003618 DNA binding site [nucleotide binding] 702459003619 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 702459003620 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 702459003621 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 702459003622 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 702459003623 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459003624 Walker A motif; other site 702459003625 ATP binding site [chemical binding]; other site 702459003626 Walker B motif; other site 702459003627 arginine finger; other site 702459003628 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 702459003629 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 702459003630 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 702459003631 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 702459003632 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 702459003633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 702459003634 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 702459003635 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 702459003636 putative C-S lyase; Region: C_S_lyase_PatB; TIGR04350 702459003637 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459003638 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459003639 homodimer interface [polypeptide binding]; other site 702459003640 catalytic residue [active] 702459003641 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 702459003642 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 702459003643 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459003644 Walker A motif; other site 702459003645 ATP binding site [chemical binding]; other site 702459003646 Walker B motif; other site 702459003647 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 702459003648 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 702459003649 oligomer interface [polypeptide binding]; other site 702459003650 active site residues [active] 702459003651 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 702459003652 oligomer interface [polypeptide binding]; other site 702459003653 active site residues [active] 702459003654 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 702459003655 putative ion selectivity filter; other site 702459003656 putative pore gating glutamate residue; other site 702459003657 trigger factor; Provisional; Region: tig; PRK01490 702459003658 Bacterial trigger factor protein (TF); Region: Trigger_N; pfam05697 702459003659 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 702459003660 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 702459003661 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 702459003662 active site 702459003663 catalytic site [active] 702459003664 substrate binding site [chemical binding]; other site 702459003665 HRDC domain; Region: HRDC; pfam00570 702459003666 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 702459003667 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 702459003668 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 702459003669 FeS/SAM binding site; other site 702459003670 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 702459003671 Pyruvate formate lyase 1; Region: PFL1; cd01678 702459003672 coenzyme A binding site [chemical binding]; other site 702459003673 active site 702459003674 catalytic residues [active] 702459003675 glycine loop; other site 702459003676 NAD synthetase; Provisional; Region: PRK13981 702459003677 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 702459003678 multimer interface [polypeptide binding]; other site 702459003679 active site 702459003680 catalytic triad [active] 702459003681 protein interface 1 [polypeptide binding]; other site 702459003682 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 702459003683 homodimer interface [polypeptide binding]; other site 702459003684 NAD binding pocket [chemical binding]; other site 702459003685 ATP binding pocket [chemical binding]; other site 702459003686 Mg binding site [ion binding]; other site 702459003687 active-site loop [active] 702459003688 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 702459003689 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 702459003690 metal binding site [ion binding]; metal-binding site 702459003691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459003692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 702459003693 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 702459003694 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459003695 active site 702459003696 motif I; other site 702459003697 motif II; other site 702459003698 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 702459003699 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 702459003700 active site 702459003701 RelB antitoxin; Region: RelB; cl01171 702459003702 PemK-like protein; Region: PemK; cl00995 702459003703 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 702459003704 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 702459003705 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 702459003706 Zn2+ binding site [ion binding]; other site 702459003707 Mg2+ binding site [ion binding]; other site 702459003708 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 702459003709 synthetase active site [active] 702459003710 NTP binding site [chemical binding]; other site 702459003711 metal binding site [ion binding]; metal-binding site 702459003712 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 702459003713 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 702459003714 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 702459003715 trimer interface [polypeptide binding]; other site 702459003716 active site 702459003717 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 702459003718 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 702459003719 Sulfatase; Region: Sulfatase; cl19157 702459003720 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 702459003721 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 702459003722 CAP-like domain; other site 702459003723 active site 702459003724 primary dimer interface [polypeptide binding]; other site 702459003725 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 702459003726 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459003727 ATP binding site [chemical binding]; other site 702459003728 putative Mg++ binding site [ion binding]; other site 702459003729 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459003730 nucleotide binding region [chemical binding]; other site 702459003731 ATP-binding site [chemical binding]; other site 702459003732 DEAD/H associated; Region: DEAD_assoc; pfam08494 702459003733 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 702459003734 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 702459003735 Aspartase; Region: Aspartase; cd01357 702459003736 active sites [active] 702459003737 tetramer interface [polypeptide binding]; other site 702459003738 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 702459003739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459003740 ATP binding site [chemical binding]; other site 702459003741 Mg2+ binding site [ion binding]; other site 702459003742 G-X-G motif; other site 702459003743 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 702459003744 anchoring element; other site 702459003745 dimer interface [polypeptide binding]; other site 702459003746 ATP binding site [chemical binding]; other site 702459003747 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 702459003748 active site 702459003749 metal binding site [ion binding]; metal-binding site 702459003750 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 702459003751 RNA polymerase sigma factor; Provisional; Region: PRK05901 702459003752 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 702459003753 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 702459003754 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 702459003755 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 702459003756 DNA binding residues [nucleotide binding] 702459003757 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 702459003758 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 702459003759 substrate binding pocket [chemical binding]; other site 702459003760 chain length determination region; other site 702459003761 substrate-Mg2+ binding site; other site 702459003762 catalytic residues [active] 702459003763 aspartate-rich region 1; other site 702459003764 active site lid residues [active] 702459003765 aspartate-rich region 2; other site 702459003766 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 702459003767 Catalytic domain of Protein Kinases; Region: PKc; cd00180 702459003768 active site 702459003769 ATP binding site [chemical binding]; other site 702459003770 substrate binding site [chemical binding]; other site 702459003771 activation loop (A-loop); other site 702459003772 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 702459003773 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 702459003774 PASTA domain; Region: PASTA; smart00740 702459003775 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 702459003776 putative acyl-acceptor binding pocket; other site 702459003777 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 702459003778 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 702459003779 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 702459003780 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 702459003781 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 702459003782 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459003783 ATP binding site [chemical binding]; other site 702459003784 putative Mg++ binding site [ion binding]; other site 702459003785 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 702459003786 SecA Wing and Scaffold domain; Region: SecA_SW; pfam07516 702459003787 SEC-C motif; Region: SEC-C; pfam02810 702459003788 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 702459003789 30S subunit binding site; other site 702459003790 recombination regulator RecX; Reviewed; Region: recX; PRK00117 702459003791 recombinase A; Provisional; Region: recA; PRK09354 702459003792 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 702459003793 hexamer interface [polypeptide binding]; other site 702459003794 Walker A motif; other site 702459003795 ATP binding site [chemical binding]; other site 702459003796 Walker B motif; other site 702459003797 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 702459003798 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 702459003799 non-specific DNA binding site [nucleotide binding]; other site 702459003800 salt bridge; other site 702459003801 sequence-specific DNA binding site [nucleotide binding]; other site 702459003802 Competence-damaged protein; Region: CinA; pfam02464 702459003803 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 702459003804 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 702459003805 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 702459003806 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 702459003807 Fic/DOC family; Region: Fic; cl00960 702459003808 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 702459003809 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 702459003810 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 702459003811 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 702459003812 FeS/SAM binding site; other site 702459003813 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 702459003814 synthetase active site [active] 702459003815 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 702459003816 NTP binding site [chemical binding]; other site 702459003817 metal binding site [ion binding]; metal-binding site 702459003818 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 702459003819 EamA-like transporter family; Region: EamA; pfam00892 702459003820 EamA-like transporter family; Region: EamA; pfam00892 702459003821 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 702459003822 Tetraspanin family; Region: Tetraspannin; pfam00335 702459003823 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 702459003824 Protein of unknown function (DUF1510); Region: DUF1510; pfam07423 702459003825 Histidine kinase; Region: HisKA_3; pfam07730 702459003826 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 702459003827 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 702459003828 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459003829 active site 702459003830 phosphorylation site [posttranslational modification] 702459003831 intermolecular recognition site; other site 702459003832 dimerization interface [polypeptide binding]; other site 702459003833 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 702459003834 DNA binding residues [nucleotide binding] 702459003835 dimerization interface [polypeptide binding]; other site 702459003836 Protein of unknown function DUF262; Region: DUF262; pfam03235 702459003837 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 702459003838 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 702459003839 active site 702459003840 dimer interface [polypeptide binding]; other site 702459003841 Guanylate kinase; Region: Guanylate_kin; pfam00625 702459003842 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 702459003843 catalytic site [active] 702459003844 G-X2-G-X-G-K; other site 702459003845 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 702459003846 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 702459003847 ATP-grasp domain; Region: ATP-grasp_4; cl17255 702459003848 Carbamoyl-phosphate synthetase large chain, oligomerization domain; Region: CPSase_L_D3; pfam02787 702459003849 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 702459003850 ATP-grasp domain; Region: ATP-grasp_4; cl17255 702459003851 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 702459003852 IMP binding site; other site 702459003853 dimer interface [polypeptide binding]; other site 702459003854 interdomain contacts; other site 702459003855 partial ornithine binding site; other site 702459003856 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 702459003857 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 702459003858 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 702459003859 catalytic site [active] 702459003860 subunit interface [polypeptide binding]; other site 702459003861 transcription antitermination factor NusB; Region: nusB; TIGR01951 702459003862 putative RNA binding site [nucleotide binding]; other site 702459003863 elongation factor P; Validated; Region: PRK00529 702459003864 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 702459003865 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 702459003866 RNA binding site [nucleotide binding]; other site 702459003867 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 702459003868 RNA binding site [nucleotide binding]; other site 702459003869 H+ Antiporter protein; Region: 2A0121; TIGR00900 702459003870 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459003871 putative substrate translocation pore; other site 702459003872 SdiA-regulated; Region: SdiA-regulated; cl19046 702459003873 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 702459003874 SdiA-regulated; Region: SdiA-regulated; cl19046 702459003875 elongation factor Tu; Reviewed; Region: PRK00049 702459003876 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 702459003877 G1 box; other site 702459003878 GEF interaction site [polypeptide binding]; other site 702459003879 GTP/Mg2+ binding site [chemical binding]; other site 702459003880 Switch I region; other site 702459003881 G2 box; other site 702459003882 G3 box; other site 702459003883 Switch II region; other site 702459003884 G4 box; other site 702459003885 G5 box; other site 702459003886 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 702459003887 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 702459003888 Antibiotic Binding Site [chemical binding]; other site 702459003889 elongation factor G; Reviewed; Region: PRK00007 702459003890 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 702459003891 G1 box; other site 702459003892 putative GEF interaction site [polypeptide binding]; other site 702459003893 GTP/Mg2+ binding site [chemical binding]; other site 702459003894 Switch I region; other site 702459003895 G2 box; other site 702459003896 G3 box; other site 702459003897 Switch II region; other site 702459003898 G4 box; other site 702459003899 G5 box; other site 702459003900 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 702459003901 Elongation Factor G, domain II; Region: EFG_II; pfam14492 702459003902 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 702459003903 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 702459003904 30S ribosomal protein S7; Validated; Region: PRK05302 702459003905 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 702459003906 S17 interaction site [polypeptide binding]; other site 702459003907 S8 interaction site; other site 702459003908 16S rRNA interaction site [nucleotide binding]; other site 702459003909 streptomycin interaction site [chemical binding]; other site 702459003910 23S rRNA interaction site [nucleotide binding]; other site 702459003911 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 702459003912 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl18945 702459003913 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 702459003914 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 702459003915 catalytic residue [active] 702459003916 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 702459003917 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 702459003918 Pectate lyase superfamily protein; Region: Pectate_lyase_3; cl19188 702459003919 Right handed beta helix region; Region: Beta_helix; pfam13229 702459003920 Disaggregatase related; Region: Disaggr_assoc; pfam08480 702459003921 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 702459003922 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 702459003923 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 702459003924 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 702459003925 ATP-grasp domain; Region: ATP-grasp_4; cl17255 702459003926 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 702459003927 ATP binding site [chemical binding]; other site 702459003928 active site 702459003929 substrate binding site [chemical binding]; other site 702459003930 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 702459003931 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 702459003932 dimerization interface [polypeptide binding]; other site 702459003933 ATP binding site [chemical binding]; other site 702459003934 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 702459003935 dimerization interface [polypeptide binding]; other site 702459003936 ATP binding site [chemical binding]; other site 702459003937 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 702459003938 putative active site [active] 702459003939 catalytic triad [active] 702459003940 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 702459003941 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 702459003942 putative active site [active] 702459003943 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 702459003944 DNA polymerase IV; Reviewed; Region: PRK03103 702459003945 Y-family of DNA polymerases; Region: PolY; cl12025 702459003946 active site 702459003947 DNA binding site [nucleotide binding] 702459003948 amidophosphoribosyltransferase; Provisional; Region: PRK07272 702459003949 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 702459003950 active site 702459003951 tetramer interface [polypeptide binding]; other site 702459003952 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459003953 active site 702459003954 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 702459003955 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 702459003956 dimerization interface [polypeptide binding]; other site 702459003957 putative ATP binding site [chemical binding]; other site 702459003958 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 702459003959 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 702459003960 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 702459003961 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 702459003962 Protein of unknown function (DUF2029); Region: DUF2029; pfam09594 702459003963 Sulfatase; Region: Sulfatase; pfam00884 702459003964 Putative esterase; Region: Esterase; pfam00756 702459003965 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819; cl19187 702459003966 Uncharacterized conserved protein [Function unknown]; Region: COG2898 702459003967 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 702459003968 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 702459003969 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 702459003970 metal binding site [ion binding]; metal-binding site 702459003971 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 702459003972 Ribosomal protein L33; Region: Ribosomal_L33; cl00383 702459003973 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 702459003974 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 702459003975 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 702459003976 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 702459003977 Predicted permease; Region: DUF318; cl17795 702459003978 TIGR03943 family protein; Region: TIGR03943 702459003979 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 702459003980 metal binding site 2 [ion binding]; metal-binding site 702459003981 putative DNA binding helix; other site 702459003982 metal binding site 1 [ion binding]; metal-binding site 702459003983 dimer interface [polypeptide binding]; other site 702459003984 structural Zn2+ binding site [ion binding]; other site 702459003985 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 702459003986 ATP-grasp domain; Region: ATP-grasp_4; cl17255 702459003987 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 702459003988 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 702459003989 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 702459003990 NAD(P) binding site [chemical binding]; other site 702459003991 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 702459003992 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 702459003993 TPP-binding site; other site 702459003994 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 702459003995 PYR/PP interface [polypeptide binding]; other site 702459003996 dimer interface [polypeptide binding]; other site 702459003997 TPP binding site [chemical binding]; other site 702459003998 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 702459003999 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 702459004000 metal binding site [ion binding]; metal-binding site 702459004001 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 702459004002 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 702459004003 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 702459004004 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 702459004005 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 702459004006 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 702459004007 putative active site [active] 702459004008 DNA primase, catalytic core; Region: dnaG; TIGR01391 702459004009 CHC2 zinc finger; Region: zf-CHC2; cl17510 702459004010 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 702459004011 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 702459004012 active site 702459004013 metal binding site [ion binding]; metal-binding site 702459004014 interdomain interaction site; other site 702459004015 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 702459004016 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 702459004017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 702459004018 Zn2+ binding site [ion binding]; other site 702459004019 Mg2+ binding site [ion binding]; other site 702459004020 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 702459004021 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 702459004022 alanine racemase; Reviewed; Region: alr; PRK00053 702459004023 active site 702459004024 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 702459004025 dimer interface [polypeptide binding]; other site 702459004026 substrate binding site [chemical binding]; other site 702459004027 catalytic residues [active] 702459004028 amino acid transporter; Region: 2A0306; TIGR00909 702459004029 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 702459004030 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 702459004031 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 702459004032 S-ribosylhomocysteinase; Provisional; Region: PRK02260 702459004033 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 702459004034 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 702459004035 ATP binding site [chemical binding]; other site 702459004036 putative Mg++ binding site [ion binding]; other site 702459004037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459004038 nucleotide binding region [chemical binding]; other site 702459004039 ATP-binding site [chemical binding]; other site 702459004040 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 702459004041 HRDC domain; Region: HRDC; pfam00570 702459004042 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 702459004043 homodimer interface [polypeptide binding]; other site 702459004044 substrate-cofactor binding pocket; other site 702459004045 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459004046 catalytic residue [active] 702459004047 cysteine synthase; Region: PLN02565 702459004048 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 702459004049 dimer interface [polypeptide binding]; other site 702459004050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459004051 catalytic residue [active] 702459004052 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 702459004053 dimerization interface [polypeptide binding]; other site 702459004054 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 702459004055 NAD binding site [chemical binding]; other site 702459004056 ligand binding site [chemical binding]; other site 702459004057 catalytic site [active] 702459004058 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 702459004059 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 702459004060 Walker A/P-loop; other site 702459004061 ATP binding site [chemical binding]; other site 702459004062 Q-loop/lid; other site 702459004063 ABC transporter signature motif; other site 702459004064 Walker B; other site 702459004065 D-loop; other site 702459004066 H-loop/switch region; other site 702459004067 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 702459004068 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 702459004069 Walker A/P-loop; other site 702459004070 ATP binding site [chemical binding]; other site 702459004071 Q-loop/lid; other site 702459004072 ABC transporter signature motif; other site 702459004073 Walker B; other site 702459004074 D-loop; other site 702459004075 H-loop/switch region; other site 702459004076 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 702459004077 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459004078 dimer interface [polypeptide binding]; other site 702459004079 conserved gate region; other site 702459004080 putative PBP binding loops; other site 702459004081 ABC-ATPase subunit interface; other site 702459004082 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 702459004083 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459004084 dimer interface [polypeptide binding]; other site 702459004085 conserved gate region; other site 702459004086 putative PBP binding loops; other site 702459004087 ABC-ATPase subunit interface; other site 702459004088 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 702459004089 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 702459004090 pantothenate kinase; Reviewed; Region: PRK13318 702459004091 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 702459004092 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 702459004093 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 702459004094 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 702459004095 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 702459004096 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 702459004097 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 702459004098 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 702459004099 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 702459004100 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459004101 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459004102 DNA binding site [nucleotide binding] 702459004103 domain linker motif; other site 702459004104 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 702459004105 ligand binding site [chemical binding]; other site 702459004106 dimerization interface (open form) [polypeptide binding]; other site 702459004107 dimerization interface (closed form) [polypeptide binding]; other site 702459004108 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 702459004109 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 702459004110 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459004111 sugar binding site [chemical binding]; other site 702459004112 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 702459004113 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 702459004114 active site 702459004115 HIGH motif; other site 702459004116 nucleotide binding site [chemical binding]; other site 702459004117 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 702459004118 active site 702459004119 KMSKS motif; other site 702459004120 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 702459004121 tRNA binding surface [nucleotide binding]; other site 702459004122 anticodon binding site; other site 702459004123 Membrane protein of unknown function; Region: DUF360; pfam04020 702459004124 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 702459004125 NAD(P) binding site [chemical binding]; other site 702459004126 catalytic residues [active] 702459004127 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 702459004128 Uncharacterized family; SPFH (stomatin, prohibitin, flotillin, and HflK/C) superfamily; Region: SPFH_like_u4; cd03407 702459004129 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 702459004130 homodimer interface [polypeptide binding]; other site 702459004131 substrate-cofactor binding pocket; other site 702459004132 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459004133 catalytic residue [active] 702459004134 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 702459004135 homodimer interface [polypeptide binding]; other site 702459004136 substrate-cofactor binding pocket; other site 702459004137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459004138 catalytic residue [active] 702459004139 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 702459004140 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 702459004141 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 702459004142 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 702459004143 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 702459004144 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 702459004145 Walker A/P-loop; other site 702459004146 ATP binding site [chemical binding]; other site 702459004147 Q-loop/lid; other site 702459004148 ABC transporter signature motif; other site 702459004149 Walker B; other site 702459004150 D-loop; other site 702459004151 H-loop/switch region; other site 702459004152 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459004153 FtsX-like permease family; Region: FtsX; pfam02687 702459004154 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 702459004155 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 702459004156 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459004157 motif II; other site 702459004158 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 702459004159 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 702459004160 Coenzyme A binding pocket [chemical binding]; other site 702459004161 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459004162 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 702459004163 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 702459004164 active site 702459004165 catalytic tetrad [active] 702459004166 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 702459004167 active site 702459004168 catalytic site [active] 702459004169 substrate binding site [chemical binding]; other site 702459004170 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 702459004171 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 702459004172 oxalacetate binding site [chemical binding]; other site 702459004173 citrylCoA binding site [chemical binding]; other site 702459004174 coenzyme A binding site [chemical binding]; other site 702459004175 catalytic triad [active] 702459004176 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 702459004177 active site 702459004178 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 702459004179 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 702459004180 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 702459004181 active site 702459004182 Zn binding site [ion binding]; other site 702459004183 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 702459004184 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 702459004185 dimer interface [polypeptide binding]; other site 702459004186 ssDNA binding site [nucleotide binding]; other site 702459004187 tetramer (dimer of dimers) interface [polypeptide binding]; other site 702459004188 prolyl-tRNA synthetase; Provisional; Region: PRK09194 702459004189 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 702459004190 dimer interface [polypeptide binding]; other site 702459004191 motif 1; other site 702459004192 active site 702459004193 motif 2; other site 702459004194 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 702459004195 putative deacylase active site [active] 702459004196 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 702459004197 active site 702459004198 motif 3; other site 702459004199 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 702459004200 anticodon binding site; other site 702459004201 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459004202 PIF1-like helicase; Region: PIF1; pfam05970 702459004203 Walker A motif; other site 702459004204 ATP binding site [chemical binding]; other site 702459004205 Walker B motif; other site 702459004206 arginine finger; other site 702459004207 UvrD-like helicase C-terminal domain; Region: UvrD_C_2; cl19402 702459004208 Helicase; Region: Herpes_Helicase; pfam02689 702459004209 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459004210 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 702459004211 active site 702459004212 motif I; other site 702459004213 motif II; other site 702459004214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459004215 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 702459004216 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 702459004217 catalytic site [active] 702459004218 putative active site [active] 702459004219 putative substrate binding site [chemical binding]; other site 702459004220 dimer interface [polypeptide binding]; other site 702459004221 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 702459004222 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459004223 active site 702459004224 dimerization interface [polypeptide binding]; other site 702459004225 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 702459004226 DNA binding site [nucleotide binding] 702459004227 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459004228 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 702459004229 ATP binding site [chemical binding]; other site 702459004230 G-X-G motif; other site 702459004231 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 702459004232 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 702459004233 active site 702459004234 catalytic site [active] 702459004235 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 702459004236 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 702459004237 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 702459004238 active site 702459004239 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 702459004240 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 702459004241 Mg++ binding site [ion binding]; other site 702459004242 putative catalytic motif [active] 702459004243 substrate binding site [chemical binding]; other site 702459004244 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 702459004245 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 702459004246 putative CoA binding site [chemical binding]; other site 702459004247 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 702459004248 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459004249 S-adenosylmethionine binding site [chemical binding]; other site 702459004250 peptide chain release factor 1; Validated; Region: prfA; PRK00591 702459004251 PCRF domain; Region: PCRF; pfam03462 702459004252 RF-1 domain; Region: RF-1; pfam00472 702459004253 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 702459004254 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 702459004255 conserved cys residue [active] 702459004256 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 702459004257 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 702459004258 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 702459004259 Sugar transport protein; Region: Sugar_transport; cl19288 702459004260 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 702459004261 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 702459004262 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 702459004263 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 702459004264 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459004265 S-adenosylmethionine binding site [chemical binding]; other site 702459004266 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 702459004267 active site 702459004268 phosphate binding residues; other site 702459004269 catalytic residues [active] 702459004270 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 702459004271 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 702459004272 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 702459004273 ATP binding site [chemical binding]; other site 702459004274 putative Mg++ binding site [ion binding]; other site 702459004275 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 702459004276 nucleotide binding region [chemical binding]; other site 702459004277 ATP-binding site [chemical binding]; other site 702459004278 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 702459004279 EamA-like transporter family; Region: EamA; pfam00892 702459004280 EamA-like transporter family; Region: EamA; pfam00892 702459004281 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 702459004282 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459004283 FtsX-like permease family; Region: FtsX; pfam02687 702459004284 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 702459004285 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 702459004286 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 702459004287 homodimer interface [polypeptide binding]; other site 702459004288 substrate-cofactor binding pocket; other site 702459004289 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459004290 catalytic residue [active] 702459004291 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 702459004292 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 702459004293 nucleotide binding site [chemical binding]; other site 702459004294 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 702459004295 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 702459004296 Walker A/P-loop; other site 702459004297 ATP binding site [chemical binding]; other site 702459004298 Q-loop/lid; other site 702459004299 ABC transporter signature motif; other site 702459004300 Walker B; other site 702459004301 D-loop; other site 702459004302 H-loop/switch region; other site 702459004303 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 702459004304 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459004305 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 702459004306 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 702459004307 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 702459004308 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 702459004309 putative active site [active] 702459004310 Protein of unknown function (DUF979); Region: DUF979; cl19737 702459004311 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 702459004312 putative substrate binding pocket [chemical binding]; other site 702459004313 AC domain interface; other site 702459004314 catalytic triad [active] 702459004315 AB domain interface; other site 702459004316 interchain disulfide; other site 702459004317 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 702459004318 Protein of unknown function (DUF3791); Region: DUF3791; pfam12668 702459004319 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 702459004320 Fic/DOC family; Region: Fic; cl00960 702459004321 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 702459004322 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459004323 active site 702459004324 phosphorylation site [posttranslational modification] 702459004325 intermolecular recognition site; other site 702459004326 dimerization interface [polypeptide binding]; other site 702459004327 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 702459004328 helix_turn_helix, Lux Regulon; Region: HTH_LUXR; smart00421 702459004329 dimerization interface [polypeptide binding]; other site 702459004330 DNA binding residues [nucleotide binding] 702459004331 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 702459004332 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 702459004333 ABC transporter; Region: ABC_tran_2; pfam12848 702459004334 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 702459004335 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 702459004336 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 702459004337 active site 702459004338 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 702459004339 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459004340 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 702459004341 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 702459004342 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 702459004343 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 702459004344 active site 702459004345 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 702459004346 catalytic triad [active] 702459004347 dimer interface [polypeptide binding]; other site 702459004348 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 702459004349 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 702459004350 homooctamer interface [polypeptide binding]; other site 702459004351 active site 702459004352 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 702459004353 catalytic center binding site [active] 702459004354 ATP binding site [chemical binding]; other site 702459004355 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 702459004356 catalytic center binding site [active] 702459004357 ATP binding site [chemical binding]; other site 702459004358 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 702459004359 Dihydropteroate synthase and related enzymes [Coenzyme metabolism]; Region: FolP; COG0294 702459004360 substrate binding pocket [chemical binding]; other site 702459004361 dimer interface [polypeptide binding]; other site 702459004362 inhibitor binding site; inhibition site 702459004363 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 702459004364 active site 702459004365 FtsH Extracellular; Region: FtsH_ext; pfam06480 702459004366 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 702459004367 Preprotein translocase subunit; Region: YajC; cl00806 702459004368 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459004369 Walker A motif; other site 702459004370 ATP binding site [chemical binding]; other site 702459004371 Walker B motif; other site 702459004372 arginine finger; other site 702459004373 Peptidase family M41; Region: Peptidase_M41; pfam01434 702459004374 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459004375 active site 702459004376 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 702459004377 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 702459004378 Ligand Binding Site [chemical binding]; other site 702459004379 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 702459004380 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 702459004381 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 702459004382 Walker A/P-loop; other site 702459004383 ATP binding site [chemical binding]; other site 702459004384 Q-loop/lid; other site 702459004385 ABC transporter signature motif; other site 702459004386 Walker B; other site 702459004387 D-loop; other site 702459004388 H-loop/switch region; other site 702459004389 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 702459004390 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 702459004391 DXD motif; other site 702459004392 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 702459004393 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 702459004394 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 702459004395 active site 702459004396 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 702459004397 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 702459004398 dimer interface [polypeptide binding]; other site 702459004399 active site 702459004400 metal binding site [ion binding]; metal-binding site 702459004401 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 702459004402 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 702459004403 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 702459004404 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 702459004405 NAD(P) binding site [chemical binding]; other site 702459004406 active site 702459004407 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 702459004408 potential protein location (Conserved hypothetical protein [Bifidobacterium bifidum PRL2010]) that overlaps RNA (tRNA-E) 702459004409 putative symporter YagG; Provisional; Region: PRK09669; cl15392 702459004410 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 702459004411 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 702459004412 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 702459004413 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 702459004414 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 702459004415 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 702459004416 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 702459004417 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459004418 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459004419 DNA binding site [nucleotide binding] 702459004420 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 702459004421 putative ligand binding site [chemical binding]; other site 702459004422 putative dimerization interface [polypeptide binding]; other site 702459004423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 702459004424 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 702459004425 dimer interface [polypeptide binding]; other site 702459004426 phosphorylation site [posttranslational modification] 702459004427 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459004428 ATP binding site [chemical binding]; other site 702459004429 Mg2+ binding site [ion binding]; other site 702459004430 G-X-G motif; other site 702459004431 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 702459004432 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459004433 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 702459004434 Walker A/P-loop; other site 702459004435 ATP binding site [chemical binding]; other site 702459004436 Q-loop/lid; other site 702459004437 ABC transporter signature motif; other site 702459004438 Walker B; other site 702459004439 D-loop; other site 702459004440 H-loop/switch region; other site 702459004441 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 702459004442 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459004443 FtsX-like permease family; Region: FtsX; pfam02687 702459004444 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 702459004445 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459004446 FtsX-like permease family; Region: FtsX; pfam02687 702459004447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459004448 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 702459004449 Walker A/P-loop; other site 702459004450 ATP binding site [chemical binding]; other site 702459004451 Q-loop/lid; other site 702459004452 ABC transporter signature motif; other site 702459004453 Walker B; other site 702459004454 D-loop; other site 702459004455 H-loop/switch region; other site 702459004456 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 702459004457 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 702459004458 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 702459004459 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 702459004460 Low molecular weight phosphatase family; Region: LMWPc; cd00115 702459004461 active site 702459004462 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 702459004463 folate binding site [chemical binding]; other site 702459004464 NADP+ binding site [chemical binding]; other site 702459004465 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 702459004466 dimerization interface [polypeptide binding]; other site 702459004467 active site 702459004468 OsmC-like protein; Region: OsmC; cl00767 702459004469 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 702459004470 Ligand Binding Site [chemical binding]; other site 702459004471 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 702459004472 Ligand Binding Site [chemical binding]; other site 702459004473 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 702459004474 NlpC/P60 family; Region: NLPC_P60; pfam00877 702459004475 CHAP domain; Region: CHAP; pfam05257 702459004476 phosphoserine aminotransferase; Provisional; Region: PRK03080 702459004477 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 702459004478 catalytic residue [active] 702459004479 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 702459004480 dimer interface [polypeptide binding]; other site 702459004481 phosphorylation site [posttranslational modification] 702459004482 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459004483 ATP binding site [chemical binding]; other site 702459004484 Mg2+ binding site [ion binding]; other site 702459004485 G-X-G motif; other site 702459004486 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 702459004487 PhoU domain; Region: PhoU; pfam01895 702459004488 PhoU domain; Region: PhoU; pfam01895 702459004489 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 702459004490 catalytic core [active] 702459004491 1,4-Dihydroxy-2-naphthoate octaprenyltransferase; Region: PT_UbiA_UBIAD1; cd13962 702459004492 putative active site [active] 702459004493 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 702459004494 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 702459004495 dimer interface [polypeptide binding]; other site 702459004496 putative anticodon binding site; other site 702459004497 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 702459004498 motif 1; other site 702459004499 dimer interface [polypeptide binding]; other site 702459004500 active site 702459004501 motif 2; other site 702459004502 motif 3; other site 702459004503 MFS transport protein AraJ; Provisional; Region: PRK10091 702459004504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459004505 putative substrate translocation pore; other site 702459004506 Tetratricopeptide repeat; Region: TPR_12; pfam13424 702459004507 Tetratricopeptide repeat; Region: TPR_12; pfam13424 702459004508 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 702459004509 binding surface 702459004510 TPR motif; other site 702459004511 Tetratricopeptide repeat; Region: TPR_12; pfam13424 702459004512 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 702459004513 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 702459004514 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 702459004515 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 702459004516 PspC domain; Region: PspC; pfam04024 702459004517 Tetraspanin family; Region: Tetraspannin; pfam00335 702459004518 PspC domain; Region: PspC; pfam04024 702459004519 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 702459004520 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 702459004521 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 702459004522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459004523 active site 702459004524 phosphorylation site [posttranslational modification] 702459004525 intermolecular recognition site; other site 702459004526 dimerization interface [polypeptide binding]; other site 702459004527 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 702459004528 DNA binding residues [nucleotide binding] 702459004529 dimerization interface [polypeptide binding]; other site 702459004530 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 702459004531 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 702459004532 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 702459004533 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 702459004534 putative active site [active] 702459004535 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 702459004536 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 702459004537 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 702459004538 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 702459004539 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 702459004540 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 702459004541 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 702459004542 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 702459004543 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459004544 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459004545 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459004546 seryl-tRNA synthetase; Provisional; Region: PRK05431 702459004547 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 702459004548 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 702459004549 dimer interface [polypeptide binding]; other site 702459004550 active site 702459004551 motif 1; other site 702459004552 motif 2; other site 702459004553 motif 3; other site 702459004554 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 702459004555 Lamin Tail Domain; Region: LTD; pfam00932 702459004556 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 702459004557 generic binding surface I; other site 702459004558 generic binding surface II; other site 702459004559 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 702459004560 putative active site [active] 702459004561 putative catalytic site [active] 702459004562 putative Mg binding site IVb [ion binding]; other site 702459004563 putative phosphate binding site [ion binding]; other site 702459004564 putative DNA binding site [nucleotide binding]; other site 702459004565 putative Mg binding site IVa [ion binding]; other site 702459004566 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 702459004567 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 702459004568 putative active site [active] 702459004569 putative metal binding site [ion binding]; other site 702459004570 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 702459004571 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 702459004572 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 702459004573 transcriptional antiterminator BglG; Provisional; Region: PRK09772 702459004574 CAT RNA binding domain; Region: CAT_RBD; smart01061 702459004575 PRD domain; Region: PRD; pfam00874 702459004576 PRD domain; Region: PRD; pfam00874 702459004577 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 702459004578 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 702459004579 active site turn [active] 702459004580 phosphorylation site [posttranslational modification] 702459004581 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 702459004582 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 702459004583 HPr interaction site; other site 702459004584 glycerol kinase (GK) interaction site [polypeptide binding]; other site 702459004585 active site 702459004586 phosphorylation site [posttranslational modification] 702459004587 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 702459004588 phosphoglucomutase; Validated; Region: PRK07564 702459004589 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 702459004590 active site 702459004591 substrate binding site [chemical binding]; other site 702459004592 metal binding site [ion binding]; metal-binding site 702459004593 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 702459004594 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 702459004595 Pyridine nucleotide-disulphide oxidoreductase, dimerization domain; Region: Pyr_redox_dim; pfam02852 702459004596 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 702459004597 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 702459004598 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459004599 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459004600 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 702459004601 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 702459004602 RNA/DNA hybrid binding site [nucleotide binding]; other site 702459004603 active site 702459004604 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 702459004605 tetramer (dimer of dimers) interface [polypeptide binding]; other site 702459004606 active site 702459004607 dimer interface [polypeptide binding]; other site 702459004608 DNA repair protein RadA; Provisional; Region: PRK11823 702459004609 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 702459004610 Walker A motif; other site 702459004611 ATP binding site [chemical binding]; other site 702459004612 Walker B motif; other site 702459004613 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 702459004614 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 702459004615 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 702459004616 active site 702459004617 Riboflavin kinase; Region: Flavokinase; smart00904 702459004618 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 702459004619 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 702459004620 RNA binding site [nucleotide binding]; other site 702459004621 active site 702459004622 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 702459004623 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 702459004624 translation initiation factor IF-2; Validated; Region: infB; PRK05306 702459004625 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 702459004626 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 702459004627 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 702459004628 G1 box; other site 702459004629 putative GEF interaction site [polypeptide binding]; other site 702459004630 GTP/Mg2+ binding site [chemical binding]; other site 702459004631 Switch I region; other site 702459004632 G2 box; other site 702459004633 G3 box; other site 702459004634 Switch II region; other site 702459004635 G4 box; other site 702459004636 G5 box; other site 702459004637 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 702459004638 Translation-initiation factor 2; Region: IF-2; pfam11987 702459004639 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 702459004640 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 702459004641 NusA N-terminal domain; Region: NusA_N; pfam08529 702459004642 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 702459004643 RNA binding site [nucleotide binding]; other site 702459004644 homodimer interface [polypeptide binding]; other site 702459004645 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 702459004646 G-X-X-G motif; other site 702459004647 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 702459004648 G-X-X-G motif; other site 702459004649 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 702459004650 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 702459004651 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 702459004652 Circularly permuted ATP-grasp type 2; Region: CP_ATPgrasp_2; cl17448 702459004653 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; cl19824 702459004654 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 702459004655 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 702459004656 dimerization interface 3.5A [polypeptide binding]; other site 702459004657 active site 702459004658 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459004659 sugar binding site [chemical binding]; other site 702459004660 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 702459004661 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 702459004662 active site 702459004663 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 702459004664 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 702459004665 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 702459004666 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 702459004667 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 702459004668 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 702459004669 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 702459004670 alphaNTD homodimer interface [polypeptide binding]; other site 702459004671 alphaNTD - beta interaction site [polypeptide binding]; other site 702459004672 alphaNTD - beta' interaction site [polypeptide binding]; other site 702459004673 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 702459004674 30S ribosomal protein S11; Validated; Region: PRK05309 702459004675 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 702459004676 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 702459004677 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 702459004678 rRNA binding site [nucleotide binding]; other site 702459004679 predicted 30S ribosome binding site; other site 702459004680 adenylate kinase; Reviewed; Region: adk; PRK00279 702459004681 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 702459004682 AMP-binding site [chemical binding]; other site 702459004683 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 702459004684 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 702459004685 SecY translocase; Region: SecY; pfam00344 702459004686 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 702459004687 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 702459004688 23S rRNA binding site [nucleotide binding]; other site 702459004689 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 702459004690 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 702459004691 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 702459004692 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 702459004693 5S rRNA interface [nucleotide binding]; other site 702459004694 L27 interface [polypeptide binding]; other site 702459004695 23S rRNA interface [nucleotide binding]; other site 702459004696 L5 interface [polypeptide binding]; other site 702459004697 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 702459004698 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 702459004699 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 702459004700 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 702459004701 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 702459004702 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 702459004703 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 702459004704 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 702459004705 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 702459004706 RNA binding site [nucleotide binding]; other site 702459004707 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 702459004708 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 702459004709 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 702459004710 23S rRNA interface [nucleotide binding]; other site 702459004711 putative translocon interaction site; other site 702459004712 signal recognition particle (SRP54) interaction site; other site 702459004713 L23 interface [polypeptide binding]; other site 702459004714 trigger factor interaction site; other site 702459004715 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 702459004716 23S rRNA interface [nucleotide binding]; other site 702459004717 5S rRNA interface [nucleotide binding]; other site 702459004718 putative antibiotic binding site [chemical binding]; other site 702459004719 L25 interface [polypeptide binding]; other site 702459004720 L27 interface [polypeptide binding]; other site 702459004721 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 702459004722 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 702459004723 G-X-X-G motif; other site 702459004724 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 702459004725 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 702459004726 protein-rRNA interface [nucleotide binding]; other site 702459004727 putative translocon binding site; other site 702459004728 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 702459004729 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 702459004730 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 702459004731 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 702459004732 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 702459004733 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 702459004734 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 702459004735 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 702459004736 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 702459004737 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 702459004738 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 702459004739 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 702459004740 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 702459004741 putative catalytic cysteine [active] 702459004742 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 702459004743 putative active site [active] 702459004744 metal binding site [ion binding]; metal-binding site 702459004745 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 702459004746 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 702459004747 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 702459004748 potential frameshift: common BLAST hit: gi|310288031|ref|YP_003939290.1| glycogen debranching enzyme GlgX 702459004749 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 702459004750 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 702459004751 potential frameshift: common BLAST hit: gi|310288031|ref|YP_003939290.1| glycogen debranching enzyme GlgX 702459004752 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 702459004753 active site 702459004754 catalytic site [active] 702459004755 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 702459004756 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 702459004757 23S rRNA interface [nucleotide binding]; other site 702459004758 L3 interface [polypeptide binding]; other site 702459004759 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 702459004760 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 702459004761 Uncharacterized conserved protein [Function unknown]; Region: COG1739 702459004762 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 702459004763 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 702459004764 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 702459004765 putative active site [active] 702459004766 putative metal binding site [ion binding]; other site 702459004767 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 702459004768 active site 702459004769 DNA polymerase IV; Validated; Region: PRK02406 702459004770 DNA binding site [nucleotide binding] 702459004771 Protein of unknown function (DUF3812); Region: DUF3812; pfam12757 702459004772 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 702459004773 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459004774 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459004775 homodimer interface [polypeptide binding]; other site 702459004776 catalytic residue [active] 702459004777 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl19102 702459004778 Ferredoxin [Energy production and conversion]; Region: COG1146 702459004779 4Fe-4S binding domain; Region: Fer4; pfam00037 702459004780 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 702459004781 FAD binding domain; Region: FAD_binding_4; pfam01565 702459004782 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 702459004783 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 702459004784 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 702459004785 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 702459004786 oligomerisation interface [polypeptide binding]; other site 702459004787 mobile loop; other site 702459004788 roof hairpin; other site 702459004789 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 702459004790 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 702459004791 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 702459004792 Zinc ribbon domain; Region: Zn-ribbon_8; cl00993 702459004793 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 702459004794 Part of AAA domain; Region: AAA_19; pfam13245 702459004795 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 702459004796 phosphopeptide binding site; other site 702459004797 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 702459004798 peripheral dimer interface [polypeptide binding]; other site 702459004799 core dimer interface [polypeptide binding]; other site 702459004800 L10 interface [polypeptide binding]; other site 702459004801 L11 interface [polypeptide binding]; other site 702459004802 putative EF-Tu interaction site [polypeptide binding]; other site 702459004803 putative EF-G interaction site [polypeptide binding]; other site 702459004804 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 702459004805 23S rRNA interface [nucleotide binding]; other site 702459004806 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 702459004807 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 702459004808 active site 702459004809 catalytic triad [active] 702459004810 oxyanion hole [active] 702459004811 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 702459004812 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 702459004813 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 702459004814 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 702459004815 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 702459004816 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 702459004817 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 702459004818 Asp-box motif; other site 702459004819 Domain of unknown function (DUF4398); Region: DUF4398; pfam14346 702459004820 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 702459004821 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 702459004822 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 702459004823 Walker A/P-loop; other site 702459004824 ATP binding site [chemical binding]; other site 702459004825 Q-loop/lid; other site 702459004826 ABC transporter signature motif; other site 702459004827 Walker B; other site 702459004828 D-loop; other site 702459004829 H-loop/switch region; other site 702459004830 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 702459004831 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459004832 dimer interface [polypeptide binding]; other site 702459004833 conserved gate region; other site 702459004834 putative PBP binding loops; other site 702459004835 ABC-ATPase subunit interface; other site 702459004836 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 702459004837 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 702459004838 dimer interface [polypeptide binding]; other site 702459004839 conserved gate region; other site 702459004840 putative PBP binding loops; other site 702459004841 ABC-ATPase subunit interface; other site 702459004842 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; cl19131 702459004843 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 702459004844 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 702459004845 active site 702459004846 phosphorylation site [posttranslational modification] 702459004847 intermolecular recognition site; other site 702459004848 dimerization interface [polypeptide binding]; other site 702459004849 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 702459004850 DNA binding site [nucleotide binding] 702459004851 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 702459004852 dimer interface [polypeptide binding]; other site 702459004853 phosphorylation site [posttranslational modification] 702459004854 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 702459004855 ATP binding site [chemical binding]; other site 702459004856 Mg2+ binding site [ion binding]; other site 702459004857 G-X-G motif; other site 702459004858 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 702459004859 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 702459004860 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 702459004861 dimerization interface [polypeptide binding]; other site 702459004862 putative DNA binding site [nucleotide binding]; other site 702459004863 putative Zn2+ binding site [ion binding]; other site 702459004864 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 702459004865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459004866 putative substrate translocation pore; other site 702459004867 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 702459004868 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 702459004869 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 702459004870 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 702459004871 trimer interface [polypeptide binding]; other site 702459004872 active site 702459004873 G bulge; other site 702459004874 Apolipophorin-III and similar insect proteins; Region: ApoLp-III_like; cl19113 702459004875 Largest subunit of RNA polymerase (RNAP), N-terminal domain; Region: RNAP_largest_subunit_N; cl19114 702459004876 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 702459004877 putative substrate binding pocket [chemical binding]; other site 702459004878 AC domain interface; other site 702459004879 catalytic triad [active] 702459004880 AB domain interface; other site 702459004881 interchain disulfide; other site 702459004882 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 702459004883 substrate binding site; other site 702459004884 dimer interface; other site 702459004885 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 702459004886 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 702459004887 potential frameshift: common BLAST hit: gi|189440132|ref|YP_001955213.1| IS30 family transposase 702459004888 Helix-turn-helix domain; Region: HTH_38; pfam13936 702459004889 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 702459004890 Integrase core domain; Region: rve; pfam00665 702459004891 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 702459004892 voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293 702459004893 active site 702459004894 catalytic tetrad [active] 702459004895 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 702459004896 catalytic residues [active] 702459004897 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 702459004898 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 702459004899 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 702459004900 Class I ribonucleotide reductase; Region: RNR_I; cd01679 702459004901 active site 702459004902 dimer interface [polypeptide binding]; other site 702459004903 catalytic residues [active] 702459004904 effector binding site; other site 702459004905 R2 peptide binding site; other site 702459004906 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 702459004907 dimer interface [polypeptide binding]; other site 702459004908 putative radical transfer pathway; other site 702459004909 diiron center [ion binding]; other site 702459004910 tyrosyl radical; other site 702459004911 Predicted membrane protein (DUF2207); Region: DUF2207; cl19878 702459004912 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 702459004913 potential frameshift: common BLAST hit: gi|310288092|ref|YP_003939351.1| Transcriptional regulator, LacI family 702459004914 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459004915 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459004916 DNA binding site [nucleotide binding] 702459004917 domain linker motif; other site 702459004918 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459004919 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 702459004920 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 702459004921 oligomer interface [polypeptide binding]; other site 702459004922 RNA binding site [nucleotide binding]; other site 702459004923 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 702459004924 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 702459004925 RNase E interface [polypeptide binding]; other site 702459004926 trimer interface [polypeptide binding]; other site 702459004927 active site 702459004928 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 702459004929 putative nucleic acid binding region [nucleotide binding]; other site 702459004930 G-X-X-G motif; other site 702459004931 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 702459004932 RNA binding site [nucleotide binding]; other site 702459004933 domain interface; other site 702459004934 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 702459004935 16S/18S rRNA binding site [nucleotide binding]; other site 702459004936 S13e-L30e interaction site [polypeptide binding]; other site 702459004937 25S rRNA binding site [nucleotide binding]; other site 702459004938 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 702459004939 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 702459004940 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl19067 702459004941 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 702459004942 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 702459004943 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 702459004944 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 702459004945 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 702459004946 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 702459004947 phosphate binding site [ion binding]; other site 702459004948 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 702459004949 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 702459004950 putative active site [active] 702459004951 putative catalytic site [active] 702459004952 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 702459004953 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 702459004954 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 702459004955 NAD(P) binding site [chemical binding]; other site 702459004956 active site 702459004957 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 702459004958 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 702459004959 active site 702459004960 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 702459004961 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 702459004962 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 702459004963 Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit; Region: ACCA; cl19172 702459004964 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 702459004965 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 702459004966 ATP-grasp domain; Region: ATP-grasp_4; cl17255 702459004967 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 702459004968 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 702459004969 carboxyltransferase (CT) interaction site; other site 702459004970 biotinylation site [posttranslational modification]; other site 702459004971 BioY family; Region: BioY; pfam02632 702459004972 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 702459004973 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 702459004974 Protein of unknown function (DUF935); Region: DUF935; cl19863 702459004975 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 702459004976 hypothetical protein; Provisional; Region: PRK03298 702459004977 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 702459004978 gamma subunit interface [polypeptide binding]; other site 702459004979 epsilon subunit interface [polypeptide binding]; other site 702459004980 LBP interface [polypeptide binding]; other site 702459004981 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 702459004982 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 702459004983 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 702459004984 alpha subunit interaction interface [polypeptide binding]; other site 702459004985 Walker A motif; other site 702459004986 ATP binding site [chemical binding]; other site 702459004987 Walker B motif; other site 702459004988 inhibitor binding site; inhibition site 702459004989 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 702459004990 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 702459004991 core domain interface [polypeptide binding]; other site 702459004992 delta subunit interface [polypeptide binding]; other site 702459004993 epsilon subunit interface [polypeptide binding]; other site 702459004994 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 702459004995 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 702459004996 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 702459004997 beta subunit interaction interface [polypeptide binding]; other site 702459004998 Walker A motif; other site 702459004999 ATP binding site [chemical binding]; other site 702459005000 Walker B motif; other site 702459005001 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 702459005002 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 702459005003 F0F1 ATP synthase subunit B; Provisional; Region: PRK14471; cl17192 702459005004 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 702459005005 ATP synthase subunit C; Region: ATP-synt_C; cl00466 702459005006 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 702459005007 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 702459005008 proposed active site lysine [active] 702459005009 conserved cys residue [active] 702459005010 Protein of unknown function (DUF497); Region: DUF497; cl01108 702459005011 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 702459005012 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 702459005013 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 702459005014 active site 702459005015 homodimer interface [polypeptide binding]; other site 702459005016 catalytic site [active] 702459005017 acceptor binding site [chemical binding]; other site 702459005018 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 702459005019 dimer interface [polypeptide binding]; other site 702459005020 substrate binding site [chemical binding]; other site 702459005021 metal binding sites [ion binding]; metal-binding site 702459005022 Predicted membrane protein [Function unknown]; Region: COG1971 702459005023 Domain of unknown function DUF; Region: DUF204; pfam02659 702459005024 Domain of unknown function DUF; Region: DUF204; pfam02659 702459005025 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 702459005026 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 702459005027 DNA binding site [nucleotide binding] 702459005028 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 702459005029 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 702459005030 minor groove reading motif; other site 702459005031 helix-hairpin-helix signature motif; other site 702459005032 substrate binding pocket [chemical binding]; other site 702459005033 active site 702459005034 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 702459005035 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 702459005036 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 702459005037 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 702459005038 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 702459005039 active site 702459005040 nucleotide binding site [chemical binding]; other site 702459005041 HIGH motif; other site 702459005042 KMSKS motif; other site 702459005043 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 702459005044 tRNA binding surface [nucleotide binding]; other site 702459005045 anticodon binding site; other site 702459005046 Membrane protein involved in colicin uptake [Cell envelope biogenesis, outer membrane]; Region: TolA; COG3064 702459005047 chorismate mutase; Provisional; Region: PRK09239 702459005048 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 702459005049 dimerization interface [polypeptide binding]; other site 702459005050 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 702459005051 putative DNA binding site [nucleotide binding]; other site 702459005052 putative Zn2+ binding site [ion binding]; other site 702459005053 AsnC family; Region: AsnC_trans_reg; pfam01037 702459005054 aspartate aminotransferase; Provisional; Region: PRK05764 702459005055 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 702459005056 pyridoxal 5'-phosphate binding site [chemical binding]; other site 702459005057 homodimer interface [polypeptide binding]; other site 702459005058 catalytic residue [active] 702459005059 transcription termination factor Rho; Provisional; Region: PRK12678 702459005060 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 702459005061 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 702459005062 RNA binding site [nucleotide binding]; other site 702459005063 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 702459005064 Walker A motif; other site 702459005065 ATP binding site [chemical binding]; other site 702459005066 Walker B motif; other site 702459005067 hypothetical protein; Provisional; Region: PRK07208 702459005068 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 702459005069 UDP-galactopyranose mutase; Region: GLF; pfam03275 702459005070 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 702459005071 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 702459005072 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 702459005073 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 702459005074 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 702459005075 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 702459005076 GatB domain; Region: GatB_Yqey; pfam02637 702459005077 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 702459005078 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 702459005079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459005080 H-loop/switch region; other site 702459005081 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459005082 Walker A/P-loop; other site 702459005083 ATP binding site [chemical binding]; other site 702459005084 Q-loop/lid; other site 702459005085 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 702459005086 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 702459005087 active site 702459005088 RmuC family; Region: RmuC; pfam02646 702459005089 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 702459005090 putative homodimer interface [polypeptide binding]; other site 702459005091 putative homotetramer interface [polypeptide binding]; other site 702459005092 putative allosteric switch controlling residues; other site 702459005093 putative metal binding site [ion binding]; other site 702459005094 putative homodimer-homodimer interface [polypeptide binding]; other site 702459005095 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 702459005096 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 702459005097 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 702459005098 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459005099 active site 702459005100 motif I; other site 702459005101 motif II; other site 702459005102 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 702459005103 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 702459005104 Uncharacterized conserved protein [Function unknown]; Region: COG3937 702459005105 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 702459005106 catalytic triad [active] 702459005107 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 702459005108 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 702459005109 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 702459005110 replicative DNA helicase; Region: DnaB; TIGR00665 702459005111 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 702459005112 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 702459005113 Walker A motif; other site 702459005114 ATP binding site [chemical binding]; other site 702459005115 Walker B motif; other site 702459005116 DNA binding loops [nucleotide binding] 702459005117 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 702459005118 putative efflux protein, MATE family; Region: matE; TIGR00797 702459005119 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 702459005120 metal binding triad; other site 702459005121 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 702459005122 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 702459005123 Zn2+ binding site [ion binding]; other site 702459005124 Mg2+ binding site [ion binding]; other site 702459005125 Nitrogen regulatory protein P-II; Region: P-II; smart00938 702459005126 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 702459005127 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 702459005128 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 702459005129 SRP54-type protein, GTPase domain; Region: SRP54; pfam00448 702459005130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 702459005131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 702459005132 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 702459005133 active site 702459005134 Glycosyl hydrolases related to GH101 family, GHL1-GHL3; Region: GHL1-3; pfam11308 702459005135 Peptidase family C69; Region: Peptidase_C69; pfam03577 702459005136 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 702459005137 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 702459005138 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 702459005139 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 702459005140 Walker A/P-loop; other site 702459005141 ATP binding site [chemical binding]; other site 702459005142 Q-loop/lid; other site 702459005143 ABC transporter signature motif; other site 702459005144 Walker B; other site 702459005145 D-loop; other site 702459005146 H-loop/switch region; other site 702459005147 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 702459005148 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 702459005149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459005150 Walker A/P-loop; other site 702459005151 ATP binding site [chemical binding]; other site 702459005152 Q-loop/lid; other site 702459005153 ABC transporter signature motif; other site 702459005154 Walker B; other site 702459005155 D-loop; other site 702459005156 H-loop/switch region; other site 702459005157 Transcriptional regulators [Transcription]; Region: MarR; COG1846 702459005158 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 702459005159 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 702459005160 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 702459005161 Cna protein B-type domain; Region: Cna_B; pfam05738 702459005162 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146 702459005163 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 702459005164 active site 702459005165 catalytic site [active] 702459005166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459005167 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 702459005168 active site 702459005169 motif I; other site 702459005170 motif II; other site 702459005171 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 702459005172 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 702459005173 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459005174 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; cl01046 702459005175 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232 702459005176 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 702459005177 methionine cluster; other site 702459005178 active site 702459005179 phosphorylation site [posttranslational modification] 702459005180 metal binding site [ion binding]; metal-binding site 702459005181 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 702459005182 active site 702459005183 P-loop; other site 702459005184 phosphorylation site [posttranslational modification] 702459005185 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 702459005186 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 702459005187 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 702459005188 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 702459005189 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 702459005190 DNA-binding site [nucleotide binding]; DNA binding site 702459005191 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 702459005192 FMN-binding domain; Region: FMN_bind; cl01081 702459005193 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 702459005194 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 702459005195 Walker A/P-loop; other site 702459005196 ATP binding site [chemical binding]; other site 702459005197 Q-loop/lid; other site 702459005198 ABC transporter signature motif; other site 702459005199 Walker B; other site 702459005200 D-loop; other site 702459005201 H-loop/switch region; other site 702459005202 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 702459005203 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459005204 FtsX-like permease family; Region: FtsX; pfam02687 702459005205 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 702459005206 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459005207 FtsX-like permease family; Region: FtsX; pfam02687 702459005208 Cytochrome oxidase subunit II; Region: Cyto_ox_2; cl12219 702459005209 Predicted membrane protein [Function unknown]; Region: COG4393 702459005210 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 702459005211 Fe2+ transport protein; Region: Iron_transport; pfam10634 702459005212 Iron permease FTR1 family; Region: FTR1; cl00475 702459005213 ApbE family; Region: ApbE; pfam02424 702459005214 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 702459005215 putative Zn2+ binding site [ion binding]; other site 702459005216 putative DNA binding site [nucleotide binding]; other site 702459005217 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 702459005218 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 702459005219 PEP-utilizing enzyme, N-terminal; Region: PEP-utilizers_N; pfam05524 702459005220 PEP-utilizing enzyme, mobile domain; Region: PEP-utilizers; pfam00391 702459005221 PEP-utilizing enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 702459005222 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 702459005223 dimerization domain swap beta strand [polypeptide binding]; other site 702459005224 regulatory protein interface [polypeptide binding]; other site 702459005225 active site 702459005226 regulatory phosphorylation site [posttranslational modification]; other site 702459005227 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459005228 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459005229 DNA binding site [nucleotide binding] 702459005230 domain linker motif; other site 702459005231 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 702459005232 dimerization interface [polypeptide binding]; other site 702459005233 ligand binding site [chemical binding]; other site 702459005234 DNA polymerase III subunit delta'; Validated; Region: PRK07940 702459005235 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459005236 Walker A motif; other site 702459005237 ATP binding site [chemical binding]; other site 702459005238 Walker B motif; other site 702459005239 arginine finger; other site 702459005240 thymidylate kinase; Validated; Region: tmk; PRK00698 702459005241 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 702459005242 TMP-binding site; other site 702459005243 ATP-binding site [chemical binding]; other site 702459005244 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 702459005245 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 702459005246 active site 702459005247 interdomain interaction site; other site 702459005248 putative metal-binding site [ion binding]; other site 702459005249 nucleotide binding site [chemical binding]; other site 702459005250 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 702459005251 domain I; other site 702459005252 DNA binding groove [nucleotide binding] 702459005253 phosphate binding site [ion binding]; other site 702459005254 domain II; other site 702459005255 domain III; other site 702459005256 nucleotide binding site [chemical binding]; other site 702459005257 catalytic site [active] 702459005258 domain IV; other site 702459005259 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 702459005260 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 702459005261 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 702459005262 active site 702459005263 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 702459005264 Subtilase family; Region: Peptidase_S8; pfam00082 702459005265 catalytic triad [active] 702459005266 putative active site [active] 702459005267 PA domain; Region: PA; pfam02225 702459005268 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 702459005269 Haemolysin-III related; Region: HlyIII; pfam03006 702459005270 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 702459005271 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 702459005272 UDP-galactopyranose mutase; Region: GLF; pfam03275 702459005273 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 702459005274 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 702459005275 Transglycosylase; Region: Transgly; pfam00912 702459005276 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 702459005277 2-isopropylmalate synthase; Validated; Region: PRK03739 702459005278 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 702459005279 active site 702459005280 catalytic residues [active] 702459005281 metal binding site [ion binding]; metal-binding site 702459005282 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 702459005283 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 702459005284 putative active site [active] 702459005285 putative metal binding site [ion binding]; other site 702459005286 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 702459005287 Double zinc ribbon; Region: DZR; pfam12773 702459005288 HemX; Region: HemX; cl19375 702459005289 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 702459005290 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 702459005291 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 702459005292 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 702459005293 Semialdehyde dehydrogenase, dimerization domain; Region: Semialdhyde_dhC; pfam02774 702459005294 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 702459005295 putative allosteric regulatory site; other site 702459005296 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AK-LysC-DapG-like_2; cd04923 702459005297 aspartate kinase; Reviewed; Region: PRK06635 702459005298 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 702459005299 putative nucleotide binding site [chemical binding]; other site 702459005300 putative catalytic residues [active] 702459005301 putative Mg ion binding site [ion binding]; other site 702459005302 putative aspartate binding site [chemical binding]; other site 702459005303 recombination protein RecR; Reviewed; Region: recR; PRK00076 702459005304 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 702459005305 DNA binding site [nucleotide binding] 702459005306 RecR protein; Region: RecR; pfam02132 702459005307 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 702459005308 putative active site [active] 702459005309 putative metal-binding site [ion binding]; other site 702459005310 tetramer interface [polypeptide binding]; other site 702459005311 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 702459005312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 702459005313 Walker A motif; other site 702459005314 ATP binding site [chemical binding]; other site 702459005315 Walker B motif; other site 702459005316 arginine finger; other site 702459005317 diacylglycerol kinase; Reviewed; Region: PRK11914 702459005318 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 702459005319 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 702459005320 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 702459005321 Type II secretion system (T2SS), protein F; Region: T2SF; cl19503 702459005322 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 702459005323 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 702459005324 Walker A motif; other site 702459005325 ATP binding site [chemical binding]; other site 702459005326 Walker B motif; other site 702459005327 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 702459005328 polyphosphate kinase; Provisional; Region: PRK05443 702459005329 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 702459005330 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 702459005331 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 702459005332 putative domain interface [polypeptide binding]; other site 702459005333 putative active site [active] 702459005334 catalytic site [active] 702459005335 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 702459005336 putative domain interface [polypeptide binding]; other site 702459005337 putative active site [active] 702459005338 catalytic site [active] 702459005339 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 702459005340 active site 702459005341 Ap6A binding site [chemical binding]; other site 702459005342 nudix motif; other site 702459005343 metal binding site [ion binding]; metal-binding site 702459005344 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 702459005345 catalytic core [active] 702459005346 PDGLE domain; Region: PDGLE; cl07986 702459005347 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 702459005348 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 702459005349 Probable Catalytic site; other site 702459005350 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 702459005351 thiS-thiF/thiG interaction site; other site 702459005352 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 702459005353 ThiS interaction site; other site 702459005354 putative active site [active] 702459005355 tetramer interface [polypeptide binding]; other site 702459005356 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 702459005357 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 702459005358 Ligand binding site; other site 702459005359 Putative Catalytic site; other site 702459005360 DXD motif; other site 702459005361 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 702459005362 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 702459005363 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 702459005364 FtsX-like permease family; Region: FtsX; pfam02687 702459005365 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 702459005366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 702459005367 ATP binding site [chemical binding]; other site 702459005368 Q-loop/lid; other site 702459005369 ABC transporter signature motif; other site 702459005370 Walker B; other site 702459005371 D-loop; other site 702459005372 H-loop/switch region; other site 702459005373 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 702459005374 Zn2+ binding site [ion binding]; other site 702459005375 Mg2+ binding site [ion binding]; other site 702459005376 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 702459005377 putative active site [active] 702459005378 putative dimer interface [polypeptide binding]; other site 702459005379 K+ potassium transporter; Region: K_trans; pfam02705 702459005380 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 702459005381 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 702459005382 active site 702459005383 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 702459005384 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459005385 dimerization interface [polypeptide binding]; other site 702459005386 ligand binding site [chemical binding]; other site 702459005387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 702459005388 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 702459005389 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 702459005390 active site 702459005391 HIGH motif; other site 702459005392 KMSKS motif; other site 702459005393 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 702459005394 tRNA binding surface [nucleotide binding]; other site 702459005395 anticodon binding site; other site 702459005396 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 702459005397 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 702459005398 putative SAM binding site [chemical binding]; other site 702459005399 putative homodimer interface [polypeptide binding]; other site 702459005400 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 702459005401 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 702459005402 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 702459005403 active site 702459005404 motif I; other site 702459005405 motif II; other site 702459005406 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 702459005407 catalytic site [active] 702459005408 BNR repeat-like domain; Region: BNR_2; pfam13088 702459005409 Asp-box motif; other site 702459005410 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 702459005411 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 702459005412 active site 702459005413 catalytic triad [active] 702459005414 oxyanion hole [active] 702459005415 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 702459005416 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 702459005417 catalytic site [active] 702459005418 Asp-box motif; other site 702459005419 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 702459005420 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 702459005421 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 702459005422 DNA binding residues [nucleotide binding] 702459005423 putative dimer interface [polypeptide binding]; other site 702459005424 chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349 702459005425 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 702459005426 HSP70 interaction site [polypeptide binding]; other site 702459005427 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 702459005428 substrate binding site [polypeptide binding]; other site 702459005429 dimer interface [polypeptide binding]; other site 702459005430 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 702459005431 dimer interface [polypeptide binding]; other site 702459005432 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 702459005433 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 702459005434 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 702459005435 nucleotide binding site [chemical binding]; other site 702459005436 NEF interaction site [polypeptide binding]; other site 702459005437 SBD interface [polypeptide binding]; other site 702459005438 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl19058 702459005439 active site 702459005440 dimer interface [polypeptide binding]; other site 702459005441 Transcriptional regulators [Transcription]; Region: PurR; COG1609 702459005442 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 702459005443 DNA binding site [nucleotide binding] 702459005444 domain linker motif; other site 702459005445 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 702459005446 ligand binding site [chemical binding]; other site 702459005447 dimerization interface [polypeptide binding]; other site 702459005448 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 702459005449 catalytic core [active] 702459005450 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 702459005451 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 702459005452 dimer interface [polypeptide binding]; other site 702459005453 FMN binding site [chemical binding]; other site 702459005454 NADPH bind site [chemical binding]; other site 702459005455 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 702459005456 Phosphotransferase enzyme family; Region: APH; pfam01636 702459005457 active site 702459005458 substrate binding site [chemical binding]; other site 702459005459 ATP binding site [chemical binding]; other site 702459005460 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 702459005461 threonine dehydratase; Provisional; Region: PRK08198 702459005462 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 702459005463 tetramer interface [polypeptide binding]; other site 702459005464 catalytic residue [active] 702459005465 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 702459005466 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 702459005467 nucleoside/Zn binding site; other site 702459005468 dimer interface [polypeptide binding]; other site 702459005469 catalytic motif [active] 702459005470 Predicted esterase [General function prediction only]; Region: COG0400 702459005471 Prolyl oligopeptidase family; Region: Peptidase_S9; cl19144 702459005472 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 702459005473 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 702459005474 trimer interface [polypeptide binding]; other site 702459005475 active site 702459005476 Melibiase; Region: Melibiase; pfam02065 702459005477 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 702459005478 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 702459005479 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 702459005480 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 702459005481 haloacid dehalogenase-like hydrolase; Region: HAD; cl19137 702459005482 Soluble P-type ATPase [General function prediction only]; Region: COG4087 702459005483 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 702459005484 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 702459005485 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 702459005486 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 702459005487 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 702459005488 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 702459005489 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 702459005490 active site 702459005491 catalytic site [active] 702459005492 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 702459005493 Cna protein B-type domain; Region: Cna_B; pfam05738 702459005494 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 702459005495 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 702459005496 domain interaction interfaces [polypeptide binding]; other site 702459005497 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 702459005498 Helix-turn-helix domain; Region: HTH_38; pfam13936 702459005499 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 702459005500 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 702459005501 Walker A/P-loop; other site 702459005502 ATP binding site [chemical binding]; other site 702459005503 Q-loop/lid; other site 702459005504 ABC transporter signature motif; other site 702459005505 Walker B; other site 702459005506 D-loop; other site 702459005507 H-loop/switch region; other site 702459005508 TOBE domain; Region: TOBE_2; pfam08402 702459005509 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 702459005510 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 702459005511 Catalytic domain of Protein Kinases; Region: PKc; cd00180 702459005512 active site 702459005513 ATP binding site [chemical binding]; other site 702459005514 substrate binding site [chemical binding]; other site 702459005515 activation loop (A-loop); other site 702459005516 Thioredoxin; Region: Thioredoxin_4; cl17273 702459005517 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 702459005518 catalytic residues [active] 702459005519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 702459005520 Domain of unknown function (DUF348); Region: DUF348; pfam03990 702459005521 Domain of unknown function (DUF348); Region: DUF348; pfam03990 702459005522 G5 domain; Region: G5; pfam07501 702459005523 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 702459005524 catalytic residue [active] 702459005525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 702459005526 S-adenosylmethionine binding site [chemical binding]; other site 702459005527 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 702459005528 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 702459005529 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 702459005530 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 702459005531 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 702459005532 active site 702459005533 NTP binding site [chemical binding]; other site 702459005534 metal binding triad [ion binding]; metal-binding site 702459005535 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 702459005536 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 702459005537 Zn2+ binding site [ion binding]; other site 702459005538 Mg2+ binding site [ion binding]; other site 702459005539 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 702459005540 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 702459005541 active site 702459005542 Ap6A binding site [chemical binding]; other site 702459005543 nudix motif; other site 702459005544 metal binding site [ion binding]; metal-binding site 702459005545 integral membrane protein MviN; Region: mviN; TIGR01695 702459005546 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 702459005547 Polysaccharide biosynthesis C-terminal domain; Region: Polysacc_synt_C; pfam14667 702459005548 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 702459005549 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 702459005550 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl19134 702459005551 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 702459005552 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 702459005553 ParB-like nuclease domain; Region: ParBc; pfam02195 702459005554 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 702459005555 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 702459005556 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 702459005557 P-loop; other site 702459005558 Magnesium ion binding site [ion binding]; other site 702459005559 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 702459005560 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 702459005561 G-X-X-G motif; other site 702459005562 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 702459005563 RxxxH motif; other site 702459005564 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 702459005565 Ribonuclease P; Region: Ribonuclease_P; pfam00825 702459005566 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399