-- dump date 20140619_002403 -- class Genbank::misc_feature -- table misc_feature_note -- id note 883062000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 883062000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062000003 Walker A motif; other site 883062000004 ATP binding site [chemical binding]; other site 883062000005 Walker B motif; other site 883062000006 arginine finger; other site 883062000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 883062000008 DnaA box-binding interface [nucleotide binding]; other site 883062000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 883062000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 883062000011 putative DNA binding surface [nucleotide binding]; other site 883062000012 dimer interface [polypeptide binding]; other site 883062000013 beta-clamp/clamp loader binding surface; other site 883062000014 beta-clamp/translesion DNA polymerase binding surface; other site 883062000015 recombination protein F; Reviewed; Region: recF; PRK00064 883062000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062000017 Walker A/P-loop; other site 883062000018 ATP binding site [chemical binding]; other site 883062000019 Q-loop/lid; other site 883062000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062000021 ABC transporter signature motif; other site 883062000022 Walker B; other site 883062000023 D-loop; other site 883062000024 H-loop/switch region; other site 883062000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 883062000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 883062000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062000028 Mg2+ binding site [ion binding]; other site 883062000029 G-X-G motif; other site 883062000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 883062000031 anchoring element; other site 883062000032 dimer interface [polypeptide binding]; other site 883062000033 ATP binding site [chemical binding]; other site 883062000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 883062000035 active site 883062000036 putative metal-binding site [ion binding]; other site 883062000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 883062000038 DNA gyrase subunit A; Validated; Region: PRK05560 883062000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 883062000040 CAP-like domain; other site 883062000041 active site 883062000042 primary dimer interface [polypeptide binding]; other site 883062000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 883062000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 883062000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 883062000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 883062000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 883062000048 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 883062000049 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 883062000050 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 883062000051 active site 883062000052 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062000053 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062000054 DNA binding site [nucleotide binding] 883062000055 domain linker motif; other site 883062000056 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 883062000057 dimerization interface [polypeptide binding]; other site 883062000058 ligand binding site [chemical binding]; other site 883062000059 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 883062000060 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 883062000061 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062000062 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 883062000063 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 883062000064 Domain of unknown function (DUF4160); Region: DUF4160; pfam13711 883062000065 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062000066 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 883062000067 non-specific DNA binding site [nucleotide binding]; other site 883062000068 salt bridge; other site 883062000069 sequence-specific DNA binding site [nucleotide binding]; other site 883062000070 glutamate dehydrogenase; Provisional; Region: PRK09414 883062000071 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 883062000072 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 883062000073 NAD(P) binding site [chemical binding]; other site 883062000074 Transcriptional regulators [Transcription]; Region: FadR; COG2186 883062000075 FCD domain; Region: FCD; pfam07729 883062000076 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 883062000077 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 883062000078 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 883062000079 conserved hypothetical protein, phage tail-like region; Region: TIGR02243 883062000080 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 883062000081 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 883062000082 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 883062000083 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 883062000084 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 883062000085 putative active site [active] 883062000086 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062000087 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062000088 DNA binding site [nucleotide binding] 883062000089 domain linker motif; other site 883062000090 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 883062000091 ligand binding site [chemical binding]; other site 883062000092 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 883062000093 active site 883062000094 phosphorylation site [posttranslational modification] 883062000095 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 883062000096 active site 883062000097 P-loop; other site 883062000098 phosphorylation site [posttranslational modification] 883062000099 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 883062000100 Protein of unknown function DUF45; Region: DUF45; pfam01863 883062000101 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 883062000102 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 883062000103 dimerization interface [polypeptide binding]; other site 883062000104 DPS ferroxidase diiron center [ion binding]; other site 883062000105 ion pore; other site 883062000106 aromatic amino acid exporter; Provisional; Region: PRK11689 883062000107 EamA-like transporter family; Region: EamA; pfam00892 883062000108 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 883062000109 Domain of unknown function DUF21; Region: DUF21; pfam01595 883062000110 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 883062000111 Transporter associated domain; Region: CorC_HlyC; smart01091 883062000112 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062000113 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062000114 DNA binding site [nucleotide binding] 883062000115 domain linker motif; other site 883062000116 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 883062000117 dimerization interface [polypeptide binding]; other site 883062000118 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 883062000119 active site clefts [active] 883062000120 zinc binding site [ion binding]; other site 883062000121 dimer interface [polypeptide binding]; other site 883062000122 peroxiredoxin; Region: AhpC; TIGR03137 883062000123 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 883062000124 dimer interface [polypeptide binding]; other site 883062000125 decamer (pentamer of dimers) interface [polypeptide binding]; other site 883062000126 catalytic triad [active] 883062000127 peroxidatic and resolving cysteines [active] 883062000128 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 883062000129 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 883062000130 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 883062000131 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 883062000132 catalytic residue [active] 883062000133 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 883062000134 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 883062000135 Divergent AAA domain; Region: AAA_4; pfam04326 883062000136 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 883062000137 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062000138 Major Facilitator Superfamily; Region: MFS_1; pfam07690 883062000139 putative substrate translocation pore; other site 883062000140 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 883062000141 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 883062000142 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 883062000143 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 883062000144 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 883062000145 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 883062000146 active site 883062000147 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 883062000148 putative active site [active] 883062000149 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 883062000150 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 883062000151 active site 883062000152 HIGH motif; other site 883062000153 dimer interface [polypeptide binding]; other site 883062000154 KMSKS motif; other site 883062000155 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 883062000156 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062000157 intermolecular recognition site; other site 883062000158 active site 883062000159 dimerization interface [polypeptide binding]; other site 883062000160 LytTr DNA-binding domain; Region: LytTR; smart00850 883062000161 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 883062000162 ATP binding site [chemical binding]; other site 883062000163 Mg2+ binding site [ion binding]; other site 883062000164 G-X-G motif; other site 883062000165 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 883062000166 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 883062000167 NAD binding site [chemical binding]; other site 883062000168 substrate binding site [chemical binding]; other site 883062000169 homodimer interface [polypeptide binding]; other site 883062000170 active site 883062000171 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 883062000172 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 883062000173 active site 883062000174 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 883062000175 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 883062000176 putative sugar binding sites [chemical binding]; other site 883062000177 Q-X-W motif; other site 883062000178 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 883062000179 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 883062000180 putative sugar binding sites [chemical binding]; other site 883062000181 Q-X-W motif; other site 883062000182 Ricin-type beta-trefoil lectin domain; Region: Ricin_B_lectin; pfam00652 883062000183 Ricin-type beta-trefoil lectin domain-like; Region: RicinB_lectin_2; pfam14200 883062000184 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cd00161 883062000185 Ricin-type beta-trefoil; Region: RICIN; smart00458 883062000186 putative sugar binding sites [chemical binding]; other site 883062000187 Q-X-W motif; other site 883062000188 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 883062000189 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 883062000190 Ligand binding site; other site 883062000191 Putative Catalytic site; other site 883062000192 DXD motif; other site 883062000193 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 883062000194 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 883062000195 NAD binding site [chemical binding]; other site 883062000196 substrate binding site [chemical binding]; other site 883062000197 homodimer interface [polypeptide binding]; other site 883062000198 active site 883062000199 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 883062000200 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 883062000201 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 883062000202 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 883062000203 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 883062000204 NADP binding site [chemical binding]; other site 883062000205 active site 883062000206 putative substrate binding site [chemical binding]; other site 883062000207 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 883062000208 putative transposase OrfB; Reviewed; Region: PHA02517 883062000209 HTH-like domain; Region: HTH_21; pfam13276 883062000210 Integrase core domain; Region: rve; pfam00665 883062000211 Integrase core domain; Region: rve_2; pfam13333 883062000212 Transposase, Mutator family; Region: Transposase_mut; pfam00872 883062000213 MULE transposase domain; Region: MULE; pfam10551 883062000214 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 883062000215 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 883062000216 substrate binding site; other site 883062000217 tetramer interface; other site 883062000218 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 883062000219 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 883062000220 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 883062000221 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 883062000222 Walker A/P-loop; other site 883062000223 ATP binding site [chemical binding]; other site 883062000224 Q-loop/lid; other site 883062000225 ABC transporter signature motif; other site 883062000226 Walker B; other site 883062000227 D-loop; other site 883062000228 H-loop/switch region; other site 883062000229 C-Terminal domain of O-antigenic polysaccharide transporter protein Wzt and related proteins; Region: Wzt_C-like; cd10147 883062000230 putative carbohydrate binding site [chemical binding]; other site 883062000231 Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439 883062000232 Rhamnan synthesis protein F; Region: RgpF; pfam05045 883062000233 putative glycosyl transferase; Provisional; Region: PRK10073 883062000234 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 883062000235 active site 883062000236 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 883062000237 Helix-turn-helix domain; Region: HTH_38; pfam13936 883062000238 Integrase core domain; Region: rve; pfam00665 883062000239 AAA domain; Region: AAA_14; pfam13173 883062000240 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 883062000241 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062000242 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 883062000243 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062000244 active site 883062000245 DNA binding site [nucleotide binding] 883062000246 Int/Topo IB signature motif; other site 883062000247 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 883062000248 Domain of unknown function (DUF955); Region: DUF955; cl01076 883062000249 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 883062000250 sequence-specific DNA binding site [nucleotide binding]; other site 883062000251 salt bridge; other site 883062000252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062000253 non-specific DNA binding site [nucleotide binding]; other site 883062000254 salt bridge; other site 883062000255 sequence-specific DNA binding site [nucleotide binding]; other site 883062000256 Prophage antirepressor [Transcription]; Region: COG3617 883062000257 BRO family, N-terminal domain; Region: Bro-N; pfam02498 883062000258 Phage antirepressor protein KilAC domain; Region: ANT; cl01462 883062000259 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 883062000260 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 883062000261 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 883062000262 nucleotide binding site [chemical binding]; other site 883062000263 polymerase nucleotide-binding site; other site 883062000264 primase nucleotide-binding site [nucleotide binding]; other site 883062000265 DNA-binding residues [nucleotide binding]; DNA binding site 883062000266 Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362 883062000267 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 883062000268 Phage terminase large subunit; Region: Terminase_3; cl12054 883062000269 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 883062000270 Bacterial EndoU nuclease; Region: EndoU_bacteria; pfam14436 883062000271 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 883062000272 major capsid protein; Region: PHA00665 883062000273 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 883062000274 tape measure domain; Region: tape_meas_nterm; TIGR02675 883062000275 Phage-related protein [Function unknown]; Region: COG5412 883062000276 Head fiber protein; Region: Phage_head_fibr; pfam11133 883062000277 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062000278 active site 883062000279 Int/Topo IB signature motif; other site 883062000280 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 883062000281 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 883062000282 hypothetical protein; Provisional; Region: PRK11770 883062000283 Domain of unknown function (DUF307); Region: DUF307; pfam03733 883062000284 Domain of unknown function (DUF307); Region: DUF307; pfam03733 883062000285 putative transporter; Provisional; Region: PRK10504 883062000286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062000287 putative substrate translocation pore; other site 883062000288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062000289 putative substrate translocation pore; other site 883062000290 FOG: CBS domain [General function prediction only]; Region: COG0517 883062000291 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 883062000292 Integrase core domain; Region: rve_3; pfam13683 883062000293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 883062000294 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 883062000295 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 883062000296 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062000297 ABC transporter signature motif; other site 883062000298 Walker B; other site 883062000299 D-loop; other site 883062000300 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 883062000301 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 883062000302 homodimer interface [polypeptide binding]; other site 883062000303 active site pocket [active] 883062000304 Rhomboid family; Region: Rhomboid; pfam01694 883062000305 HTH-like domain; Region: HTH_21; pfam13276 883062000306 Integrase core domain; Region: rve; pfam00665 883062000307 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 883062000308 putative septation inhibitor protein; Reviewed; Region: PRK02251 883062000309 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 883062000310 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 883062000311 active site 883062000312 catalytic site [active] 883062000313 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 883062000314 Glutamine amidotransferase class-I; Region: GATase; pfam00117 883062000315 glutamine binding [chemical binding]; other site 883062000316 catalytic triad [active] 883062000317 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 883062000318 Catalytic domain of Protein Kinases; Region: PKc; cd00180 883062000319 active site 883062000320 ATP binding site [chemical binding]; other site 883062000321 substrate binding site [chemical binding]; other site 883062000322 activation loop (A-loop); other site 883062000323 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 883062000324 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 883062000325 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 883062000326 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 883062000327 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 883062000328 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 883062000329 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 883062000330 active site 883062000331 ATP binding site [chemical binding]; other site 883062000332 substrate binding site [chemical binding]; other site 883062000333 activation loop (A-loop); other site 883062000334 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 883062000335 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 883062000336 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 883062000337 active site 883062000338 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 883062000339 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 883062000340 phosphopeptide binding site; other site 883062000341 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 883062000342 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 883062000343 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 883062000344 phosphopeptide binding site; other site 883062000345 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 883062000346 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 883062000347 Predicted membrane protein [Function unknown]; Region: COG1511 883062000348 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 883062000349 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 883062000350 Predicted membrane protein [Function unknown]; Region: COG1511 883062000351 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 883062000352 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 883062000353 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 883062000354 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 883062000355 EamA-like transporter family; Region: EamA; cl17759 883062000356 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 883062000357 EamA-like transporter family; Region: EamA; pfam00892 883062000358 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 883062000359 methionine sulfoxide reductase B; Provisional; Region: PRK00222 883062000360 SelR domain; Region: SelR; pfam01641 883062000361 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 883062000362 PLD-like domain; Region: PLDc_2; pfam13091 883062000363 putative homodimer interface [polypeptide binding]; other site 883062000364 putative active site [active] 883062000365 catalytic site [active] 883062000366 DEAD-like helicases superfamily; Region: DEXDc; smart00487 883062000367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062000368 ATP binding site [chemical binding]; other site 883062000369 putative Mg++ binding site [ion binding]; other site 883062000370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062000371 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 883062000372 nucleotide binding region [chemical binding]; other site 883062000373 ATP-binding site [chemical binding]; other site 883062000374 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 883062000375 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 883062000376 active site 883062000377 8-oxo-dGMP binding site [chemical binding]; other site 883062000378 nudix motif; other site 883062000379 metal binding site [ion binding]; metal-binding site 883062000380 DivIVA domain; Region: DivI1A_domain; TIGR03544 883062000381 DivIVA domain; Region: DivI1A_domain; TIGR03544 883062000382 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 883062000383 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 883062000384 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 883062000385 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 883062000386 Coenzyme A binding pocket [chemical binding]; other site 883062000387 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 883062000388 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 883062000389 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 883062000390 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 883062000391 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 883062000392 protein binding site [polypeptide binding]; other site 883062000393 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 883062000394 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 883062000395 Soluble P-type ATPase [General function prediction only]; Region: COG4087 883062000396 ferredoxin-NADP+ reductase; Region: PLN02852 883062000397 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 883062000398 heat shock protein HtpX; Provisional; Region: PRK03072 883062000399 Protein of unknown function DUF262; Region: DUF262; pfam03235 883062000400 Uncharacterized conserved protein [Function unknown]; Region: COG1479 883062000401 Protein of unknown function DUF262; Region: DUF262; pfam03235 883062000402 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 883062000403 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062000404 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 883062000405 active site 883062000406 NTP binding site [chemical binding]; other site 883062000407 metal binding triad [ion binding]; metal-binding site 883062000408 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 883062000409 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 883062000410 Coenzyme A binding pocket [chemical binding]; other site 883062000411 Polyketide cyclase / dehydrase and lipid transport; Region: Polyketide_cyc2; pfam10604 883062000412 hydrophobic ligand binding site; other site 883062000413 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 883062000414 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 883062000415 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 883062000416 Shugoshin N-terminal coiled-coil region; Region: Shugoshin_N; pfam07558 883062000417 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 883062000418 NodB motif; other site 883062000419 active site 883062000420 catalytic site [active] 883062000421 metal binding site [ion binding]; metal-binding site 883062000422 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 883062000423 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 883062000424 active site 883062000425 intersubunit interface [polypeptide binding]; other site 883062000426 zinc binding site [ion binding]; other site 883062000427 Na+ binding site [ion binding]; other site 883062000428 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 883062000429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062000430 Walker A/P-loop; other site 883062000431 ATP binding site [chemical binding]; other site 883062000432 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 883062000433 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 883062000434 GDP-binding site [chemical binding]; other site 883062000435 ACT binding site; other site 883062000436 IMP binding site; other site 883062000437 CrcB-like protein; Region: CRCB; pfam02537 883062000438 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 883062000439 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062000440 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062000441 DNA binding site [nucleotide binding] 883062000442 domain linker motif; other site 883062000443 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 883062000444 dimerization interface [polypeptide binding]; other site 883062000445 ligand binding site [chemical binding]; other site 883062000446 sodium binding site [ion binding]; other site 883062000447 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 883062000448 Major Facilitator Superfamily; Region: MFS_1; pfam07690 883062000449 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062000450 putative substrate translocation pore; other site 883062000451 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062000452 metabolite-proton symporter; Region: 2A0106; TIGR00883 883062000453 putative substrate translocation pore; other site 883062000454 ketol-acid reductoisomerase; Provisional; Region: PRK05479 883062000455 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 883062000456 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 883062000457 ketol-acid reductoisomerase; Provisional; Region: PRK05479 883062000458 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 883062000459 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 883062000460 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 883062000461 putative active site [active] 883062000462 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 883062000463 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 883062000464 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 883062000465 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 883062000466 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 883062000467 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 883062000468 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 883062000469 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 883062000470 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 883062000471 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 883062000472 Walker A/P-loop; other site 883062000473 ATP binding site [chemical binding]; other site 883062000474 Q-loop/lid; other site 883062000475 ABC transporter signature motif; other site 883062000476 Walker B; other site 883062000477 D-loop; other site 883062000478 H-loop/switch region; other site 883062000479 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 883062000480 Protein of unknown function (DUF2968); Region: DUF2968; pfam11180 883062000481 FtsX-like permease family; Region: FtsX; pfam02687 883062000482 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 883062000483 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 883062000484 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062000485 active site 883062000486 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062000487 Q-loop/lid; other site 883062000488 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 883062000489 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 883062000490 catalytic triad [active] 883062000491 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 883062000492 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 883062000493 catalytic residues [active] 883062000494 Restriction endonuclease NotI; Region: NotI; pfam12183 883062000495 CRISPR/Cas system-associated protein Csn2; Region: Csn2_like; cl09913 883062000496 tetramer interface [polypeptide binding]; other site 883062000497 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 883062000498 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 883062000499 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 883062000500 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 883062000501 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 883062000502 active site 883062000503 catalytic tetrad [active] 883062000504 Winged helix DNA-binding domain; Region: HTH_34; pfam13601 883062000505 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 883062000506 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 883062000507 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062000508 Walker A/P-loop; other site 883062000509 ATP binding site [chemical binding]; other site 883062000510 Q-loop/lid; other site 883062000511 ABC transporter signature motif; other site 883062000512 Walker B; other site 883062000513 D-loop; other site 883062000514 H-loop/switch region; other site 883062000515 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 883062000516 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 883062000517 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 883062000518 Walker A/P-loop; other site 883062000519 ATP binding site [chemical binding]; other site 883062000520 Q-loop/lid; other site 883062000521 ABC transporter signature motif; other site 883062000522 Walker B; other site 883062000523 D-loop; other site 883062000524 H-loop/switch region; other site 883062000525 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 883062000526 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 883062000527 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 883062000528 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 883062000529 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 883062000530 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 883062000531 substrate binding site [chemical binding]; other site 883062000532 Peptidase family C69; Region: Peptidase_C69; pfam03577 883062000533 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 883062000534 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 883062000535 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 883062000536 Predicted membrane protein [Function unknown]; Region: COG2246 883062000537 GtrA-like protein; Region: GtrA; pfam04138 883062000538 Major Facilitator Superfamily; Region: MFS_1; pfam07690 883062000539 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 883062000540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062000541 putative substrate translocation pore; other site 883062000542 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 883062000543 catalytic core [active] 883062000544 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 883062000545 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062000546 dimer interface [polypeptide binding]; other site 883062000547 conserved gate region; other site 883062000548 putative PBP binding loops; other site 883062000549 ABC-ATPase subunit interface; other site 883062000550 NMT1/THI5 like; Region: NMT1; pfam09084 883062000551 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 883062000552 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062000553 active site 883062000554 motif I; other site 883062000555 motif II; other site 883062000556 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 883062000557 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 883062000558 HIGH motif; other site 883062000559 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 883062000560 active site 883062000561 KMSKS motif; other site 883062000562 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 883062000563 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 883062000564 putative active site [active] 883062000565 putative metal binding site [ion binding]; other site 883062000566 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 883062000567 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 883062000568 Transcriptional regulator [Transcription]; Region: IclR; COG1414 883062000569 Bacterial transcriptional regulator; Region: IclR; pfam01614 883062000570 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 883062000571 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 883062000572 substrate binding site [chemical binding]; other site 883062000573 ligand binding site [chemical binding]; other site 883062000574 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 883062000575 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 883062000576 substrate binding site [chemical binding]; other site 883062000577 SWIM zinc finger; Region: SWIM; pfam04434 883062000578 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 883062000579 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 883062000580 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062000581 ATP binding site [chemical binding]; other site 883062000582 putative Mg++ binding site [ion binding]; other site 883062000583 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062000584 nucleotide binding region [chemical binding]; other site 883062000585 ATP-binding site [chemical binding]; other site 883062000586 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 883062000587 CAAX protease self-immunity; Region: Abi; pfam02517 883062000588 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 883062000589 active site 883062000590 FMN binding site [chemical binding]; other site 883062000591 substrate binding site [chemical binding]; other site 883062000592 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 883062000593 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 883062000594 hinge; other site 883062000595 active site 883062000596 H+ Antiporter protein; Region: 2A0121; TIGR00900 883062000597 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 883062000598 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 883062000599 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 883062000600 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 883062000601 23S rRNA interface [nucleotide binding]; other site 883062000602 L7/L12 interface [polypeptide binding]; other site 883062000603 putative thiostrepton binding site; other site 883062000604 L25 interface [polypeptide binding]; other site 883062000605 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 883062000606 mRNA/rRNA interface [nucleotide binding]; other site 883062000607 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 883062000608 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 883062000609 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 883062000610 putative active site [active] 883062000611 putative metal binding residues [ion binding]; other site 883062000612 signature motif; other site 883062000613 putative dimer interface [polypeptide binding]; other site 883062000614 putative phosphate binding site [ion binding]; other site 883062000615 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062000616 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062000617 DNA binding site [nucleotide binding] 883062000618 domain linker motif; other site 883062000619 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 883062000620 potential frameshift: common BLAST hit: gi|296454945|ref|YP_003662089.1| mandelate racemase/muconate lactonizing enzyme C-terminal 883062000621 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 883062000622 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 883062000623 substrate binding pocket [chemical binding]; other site 883062000624 classical (c) SDRs; Region: SDR_c; cd05233 883062000625 NAD(P) binding site [chemical binding]; other site 883062000626 active site 883062000627 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 883062000628 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 883062000629 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 883062000630 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 883062000631 homotrimer interaction site [polypeptide binding]; other site 883062000632 putative active site [active] 883062000633 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 883062000634 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 883062000635 active site 883062000636 catalytic site [active] 883062000637 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 883062000638 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 883062000639 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 883062000640 active site 883062000641 HIGH motif; other site 883062000642 nucleotide binding site [chemical binding]; other site 883062000643 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 883062000644 KMSK motif region; other site 883062000645 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 883062000646 tRNA binding surface [nucleotide binding]; other site 883062000647 anticodon binding site; other site 883062000648 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 883062000649 catalytic residue [active] 883062000650 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 883062000651 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 883062000652 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 883062000653 HPr interaction site; other site 883062000654 glycerol kinase (GK) interaction site [polypeptide binding]; other site 883062000655 active site 883062000656 phosphorylation site [posttranslational modification] 883062000657 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 883062000658 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 883062000659 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 883062000660 active site turn [active] 883062000661 phosphorylation site [posttranslational modification] 883062000662 homoserine dehydrogenase; Provisional; Region: PRK06349 883062000663 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 883062000664 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 883062000665 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 883062000666 homoserine kinase; Provisional; Region: PRK01212 883062000667 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 883062000668 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 883062000669 putative active site [active] 883062000670 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 883062000671 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 883062000672 nudix motif; other site 883062000673 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 883062000674 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 883062000675 Walker A/P-loop; other site 883062000676 ATP binding site [chemical binding]; other site 883062000677 Q-loop/lid; other site 883062000678 ABC transporter signature motif; other site 883062000679 Walker B; other site 883062000680 D-loop; other site 883062000681 H-loop/switch region; other site 883062000682 Predicted permeases [General function prediction only]; Region: COG0679 883062000683 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 883062000684 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 883062000685 metal binding site [ion binding]; metal-binding site 883062000686 putative dimer interface [polypeptide binding]; other site 883062000687 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 883062000688 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 883062000689 homodimer interface [polypeptide binding]; other site 883062000690 oligonucleotide binding site [chemical binding]; other site 883062000691 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 883062000692 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 883062000693 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 883062000694 GTPase CgtA; Reviewed; Region: obgE; PRK12296 883062000695 GTP1/OBG; Region: GTP1_OBG; pfam01018 883062000696 Obg GTPase; Region: Obg; cd01898 883062000697 G1 box; other site 883062000698 GTP/Mg2+ binding site [chemical binding]; other site 883062000699 Switch I region; other site 883062000700 G2 box; other site 883062000701 G3 box; other site 883062000702 Switch II region; other site 883062000703 G4 box; other site 883062000704 G5 box; other site 883062000705 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 883062000706 gamma-glutamyl kinase; Provisional; Region: PRK05429 883062000707 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 883062000708 nucleotide binding site [chemical binding]; other site 883062000709 homotetrameric interface [polypeptide binding]; other site 883062000710 putative phosphate binding site [ion binding]; other site 883062000711 putative allosteric binding site; other site 883062000712 PUA domain; Region: PUA; pfam01472 883062000713 aspartate aminotransferase; Provisional; Region: PRK05764 883062000714 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062000715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062000716 homodimer interface [polypeptide binding]; other site 883062000717 catalytic residue [active] 883062000718 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 883062000719 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 883062000720 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 883062000721 putative homodimer interface [polypeptide binding]; other site 883062000722 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 883062000723 heterodimer interface [polypeptide binding]; other site 883062000724 homodimer interface [polypeptide binding]; other site 883062000725 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 883062000726 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 883062000727 putative acyl-acceptor binding pocket; other site 883062000728 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 883062000729 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 883062000730 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 883062000731 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 883062000732 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 883062000733 ATP-grasp domain; Region: ATP-grasp_4; cl17255 883062000734 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 883062000735 active site 883062000736 catalytic site [active] 883062000737 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 883062000738 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 883062000739 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 883062000740 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062000741 sugar binding site [chemical binding]; other site 883062000742 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 883062000743 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 883062000744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062000745 active site 883062000746 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 883062000747 Double zinc ribbon; Region: DZR; pfam12773 883062000748 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 883062000749 Double zinc ribbon; Region: DZR; pfam12773 883062000750 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 883062000751 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 883062000752 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 883062000753 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 883062000754 dimer interface [polypeptide binding]; other site 883062000755 ssDNA binding site [nucleotide binding]; other site 883062000756 tetramer (dimer of dimers) interface [polypeptide binding]; other site 883062000757 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 883062000758 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 883062000759 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 883062000760 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 883062000761 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 883062000762 amphipathic channel; other site 883062000763 Asn-Pro-Ala signature motifs; other site 883062000764 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 883062000765 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 883062000766 active site 883062000767 KMSKS motif; other site 883062000768 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 883062000769 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 883062000770 catalytic residue [active] 883062000771 Acylphosphatase; Region: Acylphosphatase; pfam00708 883062000772 PA14 domain; Region: PA14; cl08459 883062000773 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 883062000774 metal ion-dependent adhesion site (MIDAS); other site 883062000775 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 883062000776 domain interaction interfaces [polypeptide binding]; other site 883062000777 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 883062000778 Cna protein B-type domain; Region: Cna_B; pfam05738 883062000779 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 883062000780 active site 883062000781 catalytic site [active] 883062000782 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 883062000783 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 883062000784 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 883062000785 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 883062000786 Clp amino terminal domain; Region: Clp_N; pfam02861 883062000787 Clp amino terminal domain; Region: Clp_N; pfam02861 883062000788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062000789 Walker A motif; other site 883062000790 ATP binding site [chemical binding]; other site 883062000791 Walker B motif; other site 883062000792 arginine finger; other site 883062000793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062000794 Walker A motif; other site 883062000795 ATP binding site [chemical binding]; other site 883062000796 Walker B motif; other site 883062000797 arginine finger; other site 883062000798 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 883062000799 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 883062000800 Mechanosensitive ion channel; Region: MS_channel; pfam00924 883062000801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 883062000802 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 883062000803 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 883062000804 aspartate aminotransferase; Provisional; Region: PRK06836 883062000805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062000806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062000807 homodimer interface [polypeptide binding]; other site 883062000808 catalytic residue [active] 883062000809 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 883062000810 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 883062000811 acyl-activating enzyme (AAE) consensus motif; other site 883062000812 putative AMP binding site [chemical binding]; other site 883062000813 putative active site [active] 883062000814 putative CoA binding site [chemical binding]; other site 883062000815 Protein of unknown function (DUF2510); Region: DUF2510; pfam10708 883062000816 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 883062000817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 883062000818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062000819 non-specific DNA binding site [nucleotide binding]; other site 883062000820 salt bridge; other site 883062000821 sequence-specific DNA binding site [nucleotide binding]; other site 883062000822 RelB antitoxin; Region: RelB; cl01171 883062000823 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 883062000824 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 883062000825 DNA binding residues [nucleotide binding] 883062000826 dimer interface [polypeptide binding]; other site 883062000827 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 883062000828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062000829 putative substrate translocation pore; other site 883062000830 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 883062000831 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 883062000832 substrate binding site [chemical binding]; other site 883062000833 ATP binding site [chemical binding]; other site 883062000834 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 883062000835 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 883062000836 ssDNA binding site; other site 883062000837 generic binding surface II; other site 883062000838 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062000839 ATP binding site [chemical binding]; other site 883062000840 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062000841 putative Mg++ binding site [ion binding]; other site 883062000842 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062000843 nucleotide binding region [chemical binding]; other site 883062000844 ATP-binding site [chemical binding]; other site 883062000845 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 883062000846 catalytic residues [active] 883062000847 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 883062000848 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 883062000849 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 883062000850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 883062000851 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 883062000852 dimer interface [polypeptide binding]; other site 883062000853 FMN binding site [chemical binding]; other site 883062000854 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 883062000855 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 883062000856 putative dimer interface [polypeptide binding]; other site 883062000857 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 883062000858 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 883062000859 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 883062000860 RimM N-terminal domain; Region: RimM; pfam01782 883062000861 hypothetical protein; Provisional; Region: PRK02821 883062000862 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 883062000863 G-X-X-G motif; other site 883062000864 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 883062000865 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 883062000866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 883062000867 DNA-binding site [nucleotide binding]; DNA binding site 883062000868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062000869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062000870 homodimer interface [polypeptide binding]; other site 883062000871 catalytic residue [active] 883062000872 LysE type translocator; Region: LysE; cl00565 883062000873 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 883062000874 putative catalytic site [active] 883062000875 putative metal binding site [ion binding]; other site 883062000876 putative phosphate binding site [ion binding]; other site 883062000877 signal recognition particle protein; Provisional; Region: PRK10867 883062000878 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 883062000879 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 883062000880 P loop; other site 883062000881 GTP binding site [chemical binding]; other site 883062000882 Signal peptide binding domain; Region: SRP_SPB; pfam02978 883062000883 Cation efflux family; Region: Cation_efflux; pfam01545 883062000884 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 883062000885 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 883062000886 active site 883062000887 HIGH motif; other site 883062000888 nucleotide binding site [chemical binding]; other site 883062000889 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 883062000890 KMSKS motif; other site 883062000891 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 883062000892 tRNA binding surface [nucleotide binding]; other site 883062000893 anticodon binding site; other site 883062000894 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 883062000895 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 883062000896 catalytic triad [active] 883062000897 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 883062000898 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 883062000899 ABC transporter; Region: ABC_tran_2; pfam12848 883062000900 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 883062000901 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 883062000902 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 883062000903 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 883062000904 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 883062000905 active site 883062000906 (T/H)XGH motif; other site 883062000907 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 883062000908 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 883062000909 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 883062000910 ribonuclease III; Reviewed; Region: rnc; PRK00102 883062000911 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 883062000912 dimerization interface [polypeptide binding]; other site 883062000913 active site 883062000914 metal binding site [ion binding]; metal-binding site 883062000915 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 883062000916 dsRNA binding site [nucleotide binding]; other site 883062000917 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 883062000918 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 883062000919 PYR/PP interface [polypeptide binding]; other site 883062000920 dimer interface [polypeptide binding]; other site 883062000921 TPP binding site [chemical binding]; other site 883062000922 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 883062000923 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 883062000924 TPP-binding site [chemical binding]; other site 883062000925 dimer interface [polypeptide binding]; other site 883062000926 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 883062000927 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 883062000928 putative valine binding site [chemical binding]; other site 883062000929 dimer interface [polypeptide binding]; other site 883062000930 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 883062000931 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 883062000932 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 883062000933 active site 883062000934 ribonuclease PH; Reviewed; Region: rph; PRK00173 883062000935 Ribonuclease PH; Region: RNase_PH_bact; cd11362 883062000936 hexamer interface [polypeptide binding]; other site 883062000937 active site 883062000938 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 883062000939 active site 883062000940 dimerization interface [polypeptide binding]; other site 883062000941 Membrane transport protein; Region: Mem_trans; cl09117 883062000942 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 883062000943 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 883062000944 active site 883062000945 dimer interface [polypeptide binding]; other site 883062000946 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 883062000947 dimer interface [polypeptide binding]; other site 883062000948 active site 883062000949 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 883062000950 MgtC family; Region: MgtC; pfam02308 883062000951 magnesium-transporting ATPase; Provisional; Region: PRK15122 883062000952 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 883062000953 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 883062000954 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 883062000955 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 883062000956 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 883062000957 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 883062000958 Walker A/P-loop; other site 883062000959 ATP binding site [chemical binding]; other site 883062000960 Q-loop/lid; other site 883062000961 ABC transporter signature motif; other site 883062000962 Walker B; other site 883062000963 D-loop; other site 883062000964 H-loop/switch region; other site 883062000965 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 883062000966 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 883062000967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062000968 dimer interface [polypeptide binding]; other site 883062000969 conserved gate region; other site 883062000970 putative PBP binding loops; other site 883062000971 ABC-ATPase subunit interface; other site 883062000972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062000973 dimer interface [polypeptide binding]; other site 883062000974 conserved gate region; other site 883062000975 putative PBP binding loops; other site 883062000976 ABC-ATPase subunit interface; other site 883062000977 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 883062000978 helix_turn_helix, cAMP Regulatory protein; Region: HTH_CRP; smart00419 883062000979 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 883062000980 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 883062000981 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 883062000982 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 883062000983 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 883062000984 putative N- and C-terminal domain interface [polypeptide binding]; other site 883062000985 putative active site [active] 883062000986 MgATP binding site [chemical binding]; other site 883062000987 catalytic site [active] 883062000988 metal binding site [ion binding]; metal-binding site 883062000989 putative xylulose binding site [chemical binding]; other site 883062000990 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 883062000991 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 883062000992 AP (apurinic/apyrimidinic) site pocket; other site 883062000993 DNA interaction; other site 883062000994 Metal-binding active site; metal-binding site 883062000995 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 883062000996 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 883062000997 intersubunit interface [polypeptide binding]; other site 883062000998 active site 883062000999 Zn2+ binding site [ion binding]; other site 883062001000 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 883062001001 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 883062001002 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 883062001003 Catalytic site [active] 883062001004 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 883062001005 RNA/DNA hybrid binding site [nucleotide binding]; other site 883062001006 active site 883062001007 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062001008 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062001009 DNA binding site [nucleotide binding] 883062001010 domain linker motif; other site 883062001011 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 883062001012 ligand binding site [chemical binding]; other site 883062001013 dimerization interface (open form) [polypeptide binding]; other site 883062001014 dimerization interface (closed form) [polypeptide binding]; other site 883062001015 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 883062001016 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 883062001017 acyl-activating enzyme (AAE) consensus motif; other site 883062001018 putative AMP binding site [chemical binding]; other site 883062001019 putative active site [active] 883062001020 putative CoA binding site [chemical binding]; other site 883062001021 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 883062001022 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 883062001023 active site 883062001024 multimer interface [polypeptide binding]; other site 883062001025 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 883062001026 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 883062001027 predicted active site [active] 883062001028 catalytic triad [active] 883062001029 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 883062001030 active site 883062001031 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062001032 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062001033 DNA binding site [nucleotide binding] 883062001034 domain linker motif; other site 883062001035 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 883062001036 ligand binding site [chemical binding]; other site 883062001037 dimerization interface [polypeptide binding]; other site 883062001038 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 883062001039 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 883062001040 active site 883062001041 catalytic tetrad [active] 883062001042 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 883062001043 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 883062001044 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 883062001045 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 883062001046 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062001047 putative substrate translocation pore; other site 883062001048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062001049 Major Facilitator Superfamily; Region: MFS_1; pfam07690 883062001050 putative substrate translocation pore; other site 883062001051 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 883062001052 Bacterial sugar transferase; Region: Bac_transf; pfam02397 883062001053 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 883062001054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062001055 ABC-ATPase subunit interface; other site 883062001056 putative PBP binding loops; other site 883062001057 Protein of unknown function (DUF4127); Region: DUF4127; pfam13552 883062001058 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 883062001059 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 883062001060 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 883062001061 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 883062001062 putative active site cavity [active] 883062001063 potential frameshift: common BLAST hit: gi|23466025|ref|NP_696628.1| DNA topoisomerase III 883062001064 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 883062001065 domain IV; other site 883062001066 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 883062001067 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 883062001068 active site 883062001069 putative interdomain interaction site [polypeptide binding]; other site 883062001070 putative metal-binding site [ion binding]; other site 883062001071 putative nucleotide binding site [chemical binding]; other site 883062001072 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 883062001073 domain I; other site 883062001074 phosphate binding site [ion binding]; other site 883062001075 CHAP domain; Region: CHAP; pfam05257 883062001076 Transposase; Region: HTH_Tnp_1; pfam01527 883062001077 potential frameshift: common BLAST hit: gi|213691189|ref|YP_002321775.1| transposase, mutator type 883062001078 Transposase, Mutator family; Region: Transposase_mut; pfam00872 883062001079 MULE transposase domain; Region: MULE; pfam10551 883062001080 Integrase core domain; Region: rve; pfam00665 883062001081 Integrase core domain; Region: rve_3; pfam13683 883062001082 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 883062001083 Domain of unknown function (DUF348); Region: DUF348; pfam03990 883062001084 G5 domain; Region: G5; pfam07501 883062001085 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 883062001086 N-acetyl-D-glucosamine binding site [chemical binding]; other site 883062001087 catalytic residue [active] 883062001088 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 883062001089 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 883062001090 catalytic residues [active] 883062001091 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 883062001092 nudix motif; other site 883062001093 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 883062001094 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 883062001095 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 883062001096 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 883062001097 putative NADH binding site [chemical binding]; other site 883062001098 putative active site [active] 883062001099 nudix motif; other site 883062001100 putative metal binding site [ion binding]; other site 883062001101 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 883062001102 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 883062001103 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 883062001104 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 883062001105 lipoyl attachment site [posttranslational modification]; other site 883062001106 Uncharacterized conserved protein [Function unknown]; Region: COG4850 883062001107 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 883062001108 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 883062001109 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 883062001110 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 883062001111 tartrate dehydrogenase; Region: TTC; TIGR02089 883062001112 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 883062001113 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 883062001114 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 883062001115 ligand binding site [chemical binding]; other site 883062001116 flexible hinge region; other site 883062001117 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 883062001118 putative switch regulator; other site 883062001119 non-specific DNA interactions [nucleotide binding]; other site 883062001120 DNA binding site [nucleotide binding] 883062001121 sequence specific DNA binding site [nucleotide binding]; other site 883062001122 putative cAMP binding site [chemical binding]; other site 883062001123 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 883062001124 Transglycosylase; Region: Transgly; pfam00912 883062001125 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 883062001126 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 883062001127 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 883062001128 active site 883062001129 FMN binding site [chemical binding]; other site 883062001130 substrate binding site [chemical binding]; other site 883062001131 homotetramer interface [polypeptide binding]; other site 883062001132 catalytic residue [active] 883062001133 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 883062001134 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 883062001135 quinone interaction residues [chemical binding]; other site 883062001136 active site 883062001137 catalytic residues [active] 883062001138 FMN binding site [chemical binding]; other site 883062001139 substrate binding site [chemical binding]; other site 883062001140 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 883062001141 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 883062001142 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 883062001143 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 883062001144 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 883062001145 dimer interface [polypeptide binding]; other site 883062001146 active site 883062001147 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 883062001148 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 883062001149 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 883062001150 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 883062001151 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062001152 metabolite-proton symporter; Region: 2A0106; TIGR00883 883062001153 putative substrate translocation pore; other site 883062001154 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 883062001155 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 883062001156 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 883062001157 potential frameshift: common BLAST hit: gi|253755821|ref|YP_003028961.1| glycosyl hydrolase family protein 883062001158 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062001159 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 883062001160 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 883062001161 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 883062001162 minor groove reading motif; other site 883062001163 helix-hairpin-helix signature motif; other site 883062001164 active site 883062001165 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 883062001166 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 883062001167 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 883062001168 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 883062001169 RPB1 interaction site [polypeptide binding]; other site 883062001170 RPB10 interaction site [polypeptide binding]; other site 883062001171 RPB11 interaction site [polypeptide binding]; other site 883062001172 RPB3 interaction site [polypeptide binding]; other site 883062001173 RPB12 interaction site [polypeptide binding]; other site 883062001174 RNA polymerase beta' subunit; Region: rpoC1; CHL00018 883062001175 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 883062001176 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 883062001177 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 883062001178 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 883062001179 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 883062001180 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 883062001181 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 883062001182 DNA binding site [nucleotide binding] 883062001183 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 883062001184 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 883062001185 phosphopeptide binding site; other site 883062001186 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 883062001187 active site 883062001188 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 883062001189 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 883062001190 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 883062001191 Protein of unknown function DUF58; Region: DUF58; pfam01882 883062001192 MoxR-like ATPases [General function prediction only]; Region: COG0714 883062001193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062001194 Walker A motif; other site 883062001195 ATP binding site [chemical binding]; other site 883062001196 Walker B motif; other site 883062001197 arginine finger; other site 883062001198 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 883062001199 Interdomain contacts; other site 883062001200 Cytokine receptor motif; other site 883062001201 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 883062001202 Catalytic domain of Protein Kinases; Region: PKc; cd00180 883062001203 active site 883062001204 ATP binding site [chemical binding]; other site 883062001205 substrate binding site [chemical binding]; other site 883062001206 activation loop (A-loop); other site 883062001207 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 883062001208 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 883062001209 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 883062001210 Part of AAA domain; Region: AAA_19; pfam13245 883062001211 Family description; Region: UvrD_C_2; pfam13538 883062001212 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 883062001213 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 883062001214 Coenzyme A binding pocket [chemical binding]; other site 883062001215 Major Facilitator Superfamily; Region: MFS_1; pfam07690 883062001216 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062001217 RelB antitoxin; Region: RelB; cl01171 883062001218 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 883062001219 dihydrodipicolinate reductase; Provisional; Region: PRK00048 883062001220 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 883062001221 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 883062001222 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 883062001223 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 883062001224 dimer interface [polypeptide binding]; other site 883062001225 active site 883062001226 catalytic residue [active] 883062001227 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 883062001228 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 883062001229 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 883062001230 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 883062001231 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 883062001232 Zn binding site [ion binding]; other site 883062001233 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 883062001234 active site 883062001235 catalytic residues [active] 883062001236 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 883062001237 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 883062001238 active site 883062001239 substrate binding site [chemical binding]; other site 883062001240 metal binding site [ion binding]; metal-binding site 883062001241 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 883062001242 active site 883062001243 catalytic residues [active] 883062001244 metal binding site [ion binding]; metal-binding site 883062001245 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 883062001246 additional DNA contacts [nucleotide binding]; other site 883062001247 mismatch recognition site; other site 883062001248 active site 883062001249 zinc binding site [ion binding]; other site 883062001250 DNA intercalation site [nucleotide binding]; other site 883062001251 aminotransferase; Validated; Region: PRK07337 883062001252 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062001253 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062001254 homodimer interface [polypeptide binding]; other site 883062001255 catalytic residue [active] 883062001256 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 883062001257 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 883062001258 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 883062001259 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 883062001260 ATP binding site [chemical binding]; other site 883062001261 substrate interface [chemical binding]; other site 883062001262 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 883062001263 active site residue [active] 883062001264 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436 883062001265 CPxP motif; other site 883062001266 DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686 883062001267 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 883062001268 active site 883062001269 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 883062001270 putative catalytic site [active] 883062001271 putative metal binding site [ion binding]; other site 883062001272 putative phosphate binding site [ion binding]; other site 883062001273 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 883062001274 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 883062001275 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 883062001276 generic binding surface II; other site 883062001277 generic binding surface I; other site 883062001278 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 883062001279 ATP cone domain; Region: ATP-cone; pfam03477 883062001280 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 883062001281 Class III ribonucleotide reductase; Region: RNR_III; cd01675 883062001282 active site 883062001283 Zn binding site [ion binding]; other site 883062001284 glycine loop; other site 883062001285 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 883062001286 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 883062001287 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 883062001288 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 883062001289 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 883062001290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 883062001291 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 883062001292 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 883062001293 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 883062001294 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 883062001295 Right handed beta helix region; Region: Beta_helix; pfam13229 883062001296 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 883062001297 MarR family; Region: MarR_2; pfam12802 883062001298 MarR family; Region: MarR_2; cl17246 883062001299 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 883062001300 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 883062001301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062001302 Walker A/P-loop; other site 883062001303 ATP binding site [chemical binding]; other site 883062001304 Q-loop/lid; other site 883062001305 ABC transporter signature motif; other site 883062001306 Walker B; other site 883062001307 D-loop; other site 883062001308 H-loop/switch region; other site 883062001309 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 883062001310 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 883062001311 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 883062001312 Walker A/P-loop; other site 883062001313 ATP binding site [chemical binding]; other site 883062001314 Q-loop/lid; other site 883062001315 ABC transporter signature motif; other site 883062001316 Walker B; other site 883062001317 D-loop; other site 883062001318 H-loop/switch region; other site 883062001319 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 883062001320 active site 883062001321 nucleophile elbow; other site 883062001322 glutamate racemase; Provisional; Region: PRK00865 883062001323 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 883062001324 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 883062001325 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 883062001326 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 883062001327 putative active site [active] 883062001328 redox center [active] 883062001329 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 883062001330 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 883062001331 active site 883062001332 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 883062001333 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 883062001334 Phosphotransferase enzyme family; Region: APH; pfam01636 883062001335 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 883062001336 substrate binding site [chemical binding]; other site 883062001337 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 883062001338 Part of AAA domain; Region: AAA_19; pfam13245 883062001339 Family description; Region: UvrD_C_2; pfam13538 883062001340 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 883062001341 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 883062001342 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 883062001343 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062001344 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062001345 DNA binding site [nucleotide binding] 883062001346 domain linker motif; other site 883062001347 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 883062001348 Domain of unknown function DUF77; Region: DUF77; pfam01910 883062001349 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 883062001350 substrate binding site [chemical binding]; other site 883062001351 dimer interface [polypeptide binding]; other site 883062001352 ATP binding site [chemical binding]; other site 883062001353 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062001354 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 883062001355 Walker A motif; other site 883062001356 ATP binding site [chemical binding]; other site 883062001357 Walker B motif; other site 883062001358 arginine finger; other site 883062001359 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 883062001360 thiamine phosphate binding site [chemical binding]; other site 883062001361 active site 883062001362 pyrophosphate binding site [ion binding]; other site 883062001363 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 883062001364 ThiC-associated domain; Region: ThiC-associated; pfam13667 883062001365 ThiC family; Region: ThiC; pfam01964 883062001366 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 883062001367 substrate binding site [chemical binding]; other site 883062001368 multimerization interface [polypeptide binding]; other site 883062001369 ATP binding site [chemical binding]; other site 883062001370 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 883062001371 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 883062001372 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 883062001373 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 883062001374 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 883062001375 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 883062001376 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 883062001377 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062001378 sugar binding site [chemical binding]; other site 883062001379 glycyl-tRNA synthetase; Provisional; Region: PRK04173 883062001380 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 883062001381 motif 1; other site 883062001382 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 883062001383 active site 883062001384 motif 2; other site 883062001385 motif 3; other site 883062001386 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 883062001387 anticodon binding site; other site 883062001388 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 883062001389 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 883062001390 FMN binding site [chemical binding]; other site 883062001391 active site 883062001392 catalytic residues [active] 883062001393 substrate binding site [chemical binding]; other site 883062001394 cell division protein FtsZ; Validated; Region: PRK09330 883062001395 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 883062001396 nucleotide binding site [chemical binding]; other site 883062001397 SulA interaction site; other site 883062001398 Protein of unknown function (DUF552); Region: DUF552; pfam04472 883062001399 YGGT family; Region: YGGT; pfam02325 883062001400 DivIVA protein; Region: DivIVA; pfam05103 883062001401 DivIVA domain; Region: DivI1A_domain; TIGR03544 883062001402 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 883062001403 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 883062001404 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 883062001405 active site 883062001406 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 883062001407 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 883062001408 putative trimer interface [polypeptide binding]; other site 883062001409 putative CoA binding site [chemical binding]; other site 883062001410 peptide chain release factor 2; Validated; Region: prfB; PRK00578 883062001411 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 883062001412 This domain is found in peptide chain release factors; Region: PCRF; smart00937 883062001413 RF-1 domain; Region: RF-1; pfam00472 883062001414 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 883062001415 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062001416 Walker A/P-loop; other site 883062001417 ATP binding site [chemical binding]; other site 883062001418 Q-loop/lid; other site 883062001419 ABC transporter signature motif; other site 883062001420 Walker B; other site 883062001421 D-loop; other site 883062001422 H-loop/switch region; other site 883062001423 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 883062001424 CHAP domain; Region: CHAP; pfam05257 883062001425 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 883062001426 SmpB-tmRNA interface; other site 883062001427 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 883062001428 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 883062001429 active site 883062001430 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 883062001431 DNA-binding interface [nucleotide binding]; DNA binding site 883062001432 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 883062001433 DivIVA domain; Region: DivI1A_domain; TIGR03544 883062001434 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 883062001435 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 883062001436 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 883062001437 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 883062001438 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 883062001439 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 883062001440 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 883062001441 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 883062001442 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 883062001443 Recombination protein O N terminal; Region: RecO_N; pfam11967 883062001444 Recombination protein O C terminal; Region: RecO_C; pfam02565 883062001445 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 883062001446 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 883062001447 catalytic residue [active] 883062001448 putative FPP diphosphate binding site; other site 883062001449 putative FPP binding hydrophobic cleft; other site 883062001450 dimer interface [polypeptide binding]; other site 883062001451 putative IPP diphosphate binding site; other site 883062001452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3878 883062001453 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 883062001454 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 883062001455 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 883062001456 active site 883062001457 PHP Thumb interface [polypeptide binding]; other site 883062001458 metal binding site [ion binding]; metal-binding site 883062001459 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 883062001460 generic binding surface II; other site 883062001461 generic binding surface I; other site 883062001462 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 883062001463 myosin-cross-reactive antigen; Provisional; Region: PRK13977 883062001464 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 883062001465 HTH domain; Region: HTH_11; pfam08279 883062001466 Predicted transcriptional regulator [Transcription]; Region: COG2378 883062001467 WYL domain; Region: WYL; pfam13280 883062001468 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 883062001469 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 883062001470 active site 883062001471 catalytic tetrad [active] 883062001472 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 883062001473 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 883062001474 active site 883062001475 catalytic tetrad [active] 883062001476 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 883062001477 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 883062001478 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 883062001479 NAD binding site [chemical binding]; other site 883062001480 dimerization interface [polypeptide binding]; other site 883062001481 product binding site; other site 883062001482 substrate binding site [chemical binding]; other site 883062001483 zinc binding site [ion binding]; other site 883062001484 catalytic residues [active] 883062001485 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 883062001486 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062001487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062001488 homodimer interface [polypeptide binding]; other site 883062001489 catalytic residue [active] 883062001490 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 883062001491 putative active site pocket [active] 883062001492 4-fold oligomerization interface [polypeptide binding]; other site 883062001493 metal binding residues [ion binding]; metal-binding site 883062001494 3-fold/trimer interface [polypeptide binding]; other site 883062001495 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 883062001496 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 883062001497 putative active site [active] 883062001498 oxyanion strand; other site 883062001499 catalytic triad [active] 883062001500 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 883062001501 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 883062001502 catalytic residues [active] 883062001503 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 883062001504 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 883062001505 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 883062001506 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 883062001507 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 883062001508 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 883062001509 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 883062001510 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 883062001511 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062001512 putative Mg++ binding site [ion binding]; other site 883062001513 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062001514 nucleotide binding region [chemical binding]; other site 883062001515 ATP-binding site [chemical binding]; other site 883062001516 Helicase associated domain (HA2); Region: HA2; pfam04408 883062001517 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 883062001518 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 883062001519 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 883062001520 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 883062001521 S-adenosylmethionine binding site [chemical binding]; other site 883062001522 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 883062001523 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 883062001524 HflX GTPase family; Region: HflX; cd01878 883062001525 G1 box; other site 883062001526 GTP/Mg2+ binding site [chemical binding]; other site 883062001527 Switch I region; other site 883062001528 G2 box; other site 883062001529 G3 box; other site 883062001530 Switch II region; other site 883062001531 G4 box; other site 883062001532 G5 box; other site 883062001533 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 883062001534 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 883062001535 NAD binding site [chemical binding]; other site 883062001536 dimer interface [polypeptide binding]; other site 883062001537 substrate binding site [chemical binding]; other site 883062001538 tetramer (dimer of dimers) interface [polypeptide binding]; other site 883062001539 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 883062001540 LexA repressor; Validated; Region: PRK00215 883062001541 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 883062001542 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 883062001543 Catalytic site [active] 883062001544 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 883062001545 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 883062001546 ATP cone domain; Region: ATP-cone; pfam03477 883062001547 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 883062001548 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 883062001549 ligand binding site [chemical binding]; other site 883062001550 NAD binding site [chemical binding]; other site 883062001551 tetramer interface [polypeptide binding]; other site 883062001552 catalytic site [active] 883062001553 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 883062001554 L-serine binding site [chemical binding]; other site 883062001555 ACT domain interface; other site 883062001556 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 883062001557 Part of AAA domain; Region: AAA_19; pfam13245 883062001558 Family description; Region: UvrD_C_2; pfam13538 883062001559 MraZ protein; Region: MraZ; pfam02381 883062001560 cell division protein MraZ; Reviewed; Region: PRK00326 883062001561 MraZ protein; Region: MraZ; pfam02381 883062001562 MraW methylase family; Region: Methyltransf_5; cl17771 883062001563 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 883062001564 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 883062001565 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 883062001566 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 883062001567 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 883062001568 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 883062001569 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 883062001570 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 883062001571 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 883062001572 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 883062001573 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 883062001574 Mg++ binding site [ion binding]; other site 883062001575 putative catalytic motif [active] 883062001576 putative substrate binding site [chemical binding]; other site 883062001577 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 883062001578 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 883062001579 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 883062001580 cell division protein FtsW; Region: ftsW; TIGR02614 883062001581 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 883062001582 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 883062001583 active site 883062001584 homodimer interface [polypeptide binding]; other site 883062001585 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 883062001586 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 883062001587 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 883062001588 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 883062001589 cell division protein FtsQ; Provisional; Region: PRK05529 883062001590 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 883062001591 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 883062001592 putative active site [active] 883062001593 dimerization interface [polypeptide binding]; other site 883062001594 putative tRNAtyr binding site [nucleotide binding]; other site 883062001595 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062001596 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 883062001597 putative substrate translocation pore; other site 883062001598 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 883062001599 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 883062001600 putative substrate binding site [chemical binding]; other site 883062001601 putative ATP binding site [chemical binding]; other site 883062001602 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 883062001603 dimerization interface [polypeptide binding]; other site 883062001604 putative DNA binding site [nucleotide binding]; other site 883062001605 Transcriptional regulators [Transcription]; Region: MarR; COG1846 883062001606 putative Zn2+ binding site [ion binding]; other site 883062001607 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 883062001608 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 883062001609 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 883062001610 CutC family; Region: CutC; cl01218 883062001611 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 883062001612 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 883062001613 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 883062001614 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 883062001615 active site 883062001616 trimer interface [polypeptide binding]; other site 883062001617 allosteric site; other site 883062001618 active site lid [active] 883062001619 hexamer (dimer of trimers) interface [polypeptide binding]; other site 883062001620 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 883062001621 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 883062001622 active site 883062001623 dimer interface [polypeptide binding]; other site 883062001624 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 883062001625 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519 883062001626 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 883062001627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062001628 ABC-ATPase subunit interface; other site 883062001629 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 883062001630 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 883062001631 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062001632 dimer interface [polypeptide binding]; other site 883062001633 conserved gate region; other site 883062001634 ABC-ATPase subunit interface; other site 883062001635 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 883062001636 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 883062001637 Walker A/P-loop; other site 883062001638 ATP binding site [chemical binding]; other site 883062001639 Q-loop/lid; other site 883062001640 ABC transporter signature motif; other site 883062001641 Walker B; other site 883062001642 D-loop; other site 883062001643 H-loop/switch region; other site 883062001644 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 883062001645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 883062001646 Walker A/P-loop; other site 883062001647 ATP binding site [chemical binding]; other site 883062001648 Q-loop/lid; other site 883062001649 ABC transporter signature motif; other site 883062001650 Walker B; other site 883062001651 D-loop; other site 883062001652 H-loop/switch region; other site 883062001653 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 883062001654 proline aminopeptidase P II; Provisional; Region: PRK10879 883062001655 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 883062001656 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 883062001657 active site 883062001658 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 883062001659 nudix motif; other site 883062001660 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 883062001661 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 883062001662 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 883062001663 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 883062001664 Walker A/P-loop; other site 883062001665 ATP binding site [chemical binding]; other site 883062001666 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 883062001667 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 883062001668 ABC transporter signature motif; other site 883062001669 Walker B; other site 883062001670 D-loop; other site 883062001671 H-loop/switch region; other site 883062001672 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 883062001673 aspartate racemase; Region: asp_race; TIGR00035 883062001674 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 883062001675 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 883062001676 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 883062001677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 883062001678 catalytic residue [active] 883062001679 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 883062001680 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 883062001681 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 883062001682 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 883062001683 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 883062001684 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 883062001685 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 883062001686 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 883062001687 DNA binding residues [nucleotide binding] 883062001688 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 883062001689 active site 883062001690 catalytic residues [active] 883062001691 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 883062001692 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 883062001693 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 883062001694 putative deacylase active site [active] 883062001695 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 883062001696 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 883062001697 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 883062001698 Thiamine pyrophosphokinase; Region: TPK; cd07995 883062001699 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 883062001700 active site 883062001701 dimerization interface [polypeptide binding]; other site 883062001702 thiamine binding site [chemical binding]; other site 883062001703 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 883062001704 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 883062001705 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 883062001706 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 883062001707 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 883062001708 23S rRNA binding site [nucleotide binding]; other site 883062001709 L21 binding site [polypeptide binding]; other site 883062001710 L13 binding site [polypeptide binding]; other site 883062001711 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 883062001712 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 883062001713 active site 883062001714 Int/Topo IB signature motif; other site 883062001715 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 883062001716 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 883062001717 P-loop; other site 883062001718 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 883062001719 Magnesium ion binding site [ion binding]; other site 883062001720 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 883062001721 Magnesium ion binding site [ion binding]; other site 883062001722 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 883062001723 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 883062001724 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 883062001725 nudix motif; other site 883062001726 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 883062001727 quinolinate synthetase; Provisional; Region: PRK09375 883062001728 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 883062001729 L-aspartate oxidase; Provisional; Region: PRK06175 883062001730 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 883062001731 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 883062001732 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 883062001733 dimerization interface [polypeptide binding]; other site 883062001734 active site 883062001735 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 883062001736 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 883062001737 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 883062001738 catalytic residue [active] 883062001739 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 883062001740 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 883062001741 G1 box; other site 883062001742 putative GEF interaction site [polypeptide binding]; other site 883062001743 GTP/Mg2+ binding site [chemical binding]; other site 883062001744 Switch I region; other site 883062001745 G2 box; other site 883062001746 G3 box; other site 883062001747 Switch II region; other site 883062001748 G4 box; other site 883062001749 G5 box; other site 883062001750 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 883062001751 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 883062001752 Prephenate dehydratase; Region: PDT; pfam00800 883062001753 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 883062001754 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 883062001755 putative L-Phe binding site [chemical binding]; other site 883062001756 prephenate dehydrogenase; Validated; Region: PRK08507 883062001757 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 883062001758 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062001759 active site 883062001760 DNA binding site [nucleotide binding] 883062001761 Int/Topo IB signature motif; other site 883062001762 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 883062001763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062001764 dimer interface [polypeptide binding]; other site 883062001765 conserved gate region; other site 883062001766 putative PBP binding loops; other site 883062001767 ABC-ATPase subunit interface; other site 883062001768 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 883062001769 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062001770 dimer interface [polypeptide binding]; other site 883062001771 conserved gate region; other site 883062001772 putative PBP binding loops; other site 883062001773 ABC-ATPase subunit interface; other site 883062001774 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 883062001775 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 883062001776 Walker A/P-loop; other site 883062001777 ATP binding site [chemical binding]; other site 883062001778 Q-loop/lid; other site 883062001779 ABC transporter signature motif; other site 883062001780 Walker B; other site 883062001781 D-loop; other site 883062001782 H-loop/switch region; other site 883062001783 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 883062001784 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 883062001785 Walker A/P-loop; other site 883062001786 ATP binding site [chemical binding]; other site 883062001787 Q-loop/lid; other site 883062001788 ABC transporter signature motif; other site 883062001789 Walker B; other site 883062001790 D-loop; other site 883062001791 H-loop/switch region; other site 883062001792 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 883062001793 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 883062001794 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 883062001795 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 883062001796 trimer interface [polypeptide binding]; other site 883062001797 active site 883062001798 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 883062001799 putative active site [active] 883062001800 putative catalytic site [active] 883062001801 putative DNA binding site [nucleotide binding]; other site 883062001802 putative phosphate binding site [ion binding]; other site 883062001803 metal binding site A [ion binding]; metal-binding site 883062001804 putative AP binding site [nucleotide binding]; other site 883062001805 putative metal binding site B [ion binding]; other site 883062001806 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 883062001807 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 883062001808 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 883062001809 TRAM domain; Region: TRAM; cl01282 883062001810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 883062001811 S-adenosylmethionine binding site [chemical binding]; other site 883062001812 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 883062001813 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 883062001814 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 883062001815 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 883062001816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 883062001817 motif II; other site 883062001818 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 883062001819 aconitate hydratase; Validated; Region: PRK09277 883062001820 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 883062001821 substrate binding site [chemical binding]; other site 883062001822 ligand binding site [chemical binding]; other site 883062001823 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 883062001824 substrate binding site [chemical binding]; other site 883062001825 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 883062001826 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 883062001827 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 883062001828 S-adenosylmethionine synthetase; Validated; Region: PRK05250 883062001829 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 883062001830 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 883062001831 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 883062001832 primosome assembly protein PriA; Provisional; Region: PRK14873 883062001833 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 883062001834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062001835 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 883062001836 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 883062001837 putative active site [active] 883062001838 substrate binding site [chemical binding]; other site 883062001839 putative cosubstrate binding site; other site 883062001840 catalytic site [active] 883062001841 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 883062001842 substrate binding site [chemical binding]; other site 883062001843 phosphoserine phosphatase SerB; Region: serB; TIGR00338 883062001844 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062001845 motif II; other site 883062001846 proteasome ATPase; Region: pup_AAA; TIGR03689 883062001847 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062001848 Walker A motif; other site 883062001849 ATP binding site [chemical binding]; other site 883062001850 Walker B motif; other site 883062001851 arginine finger; other site 883062001852 Pup-ligase protein; Region: Pup_ligase; cl15463 883062001853 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 883062001854 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 883062001855 active site 883062001856 Pup-like protein; Region: Pup; cl05289 883062001857 Pup-ligase protein; Region: Pup_ligase; cl15463 883062001858 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 883062001859 IHF dimer interface [polypeptide binding]; other site 883062001860 IHF - DNA interface [nucleotide binding]; other site 883062001861 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 883062001862 adenylosuccinate lyase; Provisional; Region: PRK09285 883062001863 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 883062001864 tetramer interface [polypeptide binding]; other site 883062001865 active site 883062001866 Secretory lipase; Region: LIP; pfam03583 883062001867 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 883062001868 metal ion-dependent adhesion site (MIDAS); other site 883062001869 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 883062001870 metal ion-dependent adhesion site (MIDAS); other site 883062001871 Protein of unknown function DUF58; Region: DUF58; pfam01882 883062001872 MoxR-like ATPases [General function prediction only]; Region: COG0714 883062001873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 883062001874 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 883062001875 ligand binding site [chemical binding]; other site 883062001876 active site 883062001877 UGI interface [polypeptide binding]; other site 883062001878 catalytic site [active] 883062001879 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 883062001880 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 883062001881 DNA-binding site [nucleotide binding]; DNA binding site 883062001882 RNA-binding motif; other site 883062001883 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 883062001884 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 883062001885 ring oligomerisation interface [polypeptide binding]; other site 883062001886 ATP/Mg binding site [chemical binding]; other site 883062001887 stacking interactions; other site 883062001888 hinge regions; other site 883062001889 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 883062001890 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 883062001891 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062001892 active site 883062001893 phosphorylation site [posttranslational modification] 883062001894 intermolecular recognition site; other site 883062001895 dimerization interface [polypeptide binding]; other site 883062001896 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 883062001897 DNA binding site [nucleotide binding] 883062001898 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 883062001899 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 883062001900 dimerization interface [polypeptide binding]; other site 883062001901 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 883062001902 dimer interface [polypeptide binding]; other site 883062001903 phosphorylation site [posttranslational modification] 883062001904 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062001905 ATP binding site [chemical binding]; other site 883062001906 Mg2+ binding site [ion binding]; other site 883062001907 G-X-G motif; other site 883062001908 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 883062001909 DNA-binding site [nucleotide binding]; DNA binding site 883062001910 RNA-binding motif; other site 883062001911 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 883062001912 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 883062001913 Ligand Binding Site [chemical binding]; other site 883062001914 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 883062001915 Ligand Binding Site [chemical binding]; other site 883062001916 Clp protease ATP binding subunit; Region: clpC; CHL00095 883062001917 Clp amino terminal domain; Region: Clp_N; pfam02861 883062001918 Clp amino terminal domain; Region: Clp_N; pfam02861 883062001919 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062001920 Walker A motif; other site 883062001921 ATP binding site [chemical binding]; other site 883062001922 Walker B motif; other site 883062001923 arginine finger; other site 883062001924 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062001925 Walker A motif; other site 883062001926 ATP binding site [chemical binding]; other site 883062001927 Walker B motif; other site 883062001928 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 883062001929 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 883062001930 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 883062001931 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 883062001932 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 883062001933 dimer interface [polypeptide binding]; other site 883062001934 motif 1; other site 883062001935 active site 883062001936 motif 2; other site 883062001937 motif 3; other site 883062001938 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 883062001939 anticodon binding site; other site 883062001940 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 883062001941 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 883062001942 dimer interface [polypeptide binding]; other site 883062001943 anticodon binding site; other site 883062001944 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 883062001945 motif 1; other site 883062001946 dimer interface [polypeptide binding]; other site 883062001947 active site 883062001948 motif 2; other site 883062001949 GAD domain; Region: GAD; pfam02938 883062001950 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 883062001951 active site 883062001952 motif 3; other site 883062001953 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062001954 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 883062001955 active site 883062001956 phosphorylation site [posttranslational modification] 883062001957 intermolecular recognition site; other site 883062001958 dimerization interface [polypeptide binding]; other site 883062001959 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 883062001960 DNA binding residues [nucleotide binding] 883062001961 dimerization interface [polypeptide binding]; other site 883062001962 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 883062001963 putative deacylase active site [active] 883062001964 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 883062001965 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 883062001966 Walker A/P-loop; other site 883062001967 ATP binding site [chemical binding]; other site 883062001968 Q-loop/lid; other site 883062001969 ABC transporter signature motif; other site 883062001970 Walker B; other site 883062001971 D-loop; other site 883062001972 H-loop/switch region; other site 883062001973 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 883062001974 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 883062001975 substrate binding pocket [chemical binding]; other site 883062001976 membrane-bound complex binding site; other site 883062001977 hinge residues; other site 883062001978 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062001979 dimer interface [polypeptide binding]; other site 883062001980 conserved gate region; other site 883062001981 ABC-ATPase subunit interface; other site 883062001982 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 883062001983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062001984 dimer interface [polypeptide binding]; other site 883062001985 conserved gate region; other site 883062001986 putative PBP binding loops; other site 883062001987 ABC-ATPase subunit interface; other site 883062001988 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 883062001989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062001990 ATP binding site [chemical binding]; other site 883062001991 putative Mg++ binding site [ion binding]; other site 883062001992 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062001993 nucleotide binding region [chemical binding]; other site 883062001994 ATP-binding site [chemical binding]; other site 883062001995 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 883062001996 recombination factor protein RarA; Reviewed; Region: PRK13342 883062001997 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062001998 Walker A motif; other site 883062001999 ATP binding site [chemical binding]; other site 883062002000 Walker B motif; other site 883062002001 arginine finger; other site 883062002002 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 883062002003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062002004 putative substrate translocation pore; other site 883062002005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062002006 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 883062002007 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 883062002008 Walker A/P-loop; other site 883062002009 ATP binding site [chemical binding]; other site 883062002010 Q-loop/lid; other site 883062002011 ABC transporter signature motif; other site 883062002012 Walker B; other site 883062002013 D-loop; other site 883062002014 H-loop/switch region; other site 883062002015 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 883062002016 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 883062002017 Walker A/P-loop; other site 883062002018 ATP binding site [chemical binding]; other site 883062002019 Q-loop/lid; other site 883062002020 ABC transporter signature motif; other site 883062002021 Walker B; other site 883062002022 D-loop; other site 883062002023 H-loop/switch region; other site 883062002024 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 883062002025 Predicted membrane protein [Function unknown]; Region: COG3601 883062002026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 883062002027 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 883062002028 nucleotide binding site [chemical binding]; other site 883062002029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062002030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062002031 homodimer interface [polypeptide binding]; other site 883062002032 catalytic residue [active] 883062002033 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062002034 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 883062002035 Walker A/P-loop; other site 883062002036 ATP binding site [chemical binding]; other site 883062002037 Q-loop/lid; other site 883062002038 ABC transporter signature motif; other site 883062002039 Walker B; other site 883062002040 D-loop; other site 883062002041 H-loop/switch region; other site 883062002042 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 883062002043 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 883062002044 binding surface 883062002045 TPR motif; other site 883062002046 Ligase N family; Region: LIGANc; smart00532 883062002047 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 883062002048 nucleotide binding pocket [chemical binding]; other site 883062002049 K-X-D-G motif; other site 883062002050 catalytic site [active] 883062002051 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 883062002052 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 883062002053 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 883062002054 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 883062002055 Dimer interface [polypeptide binding]; other site 883062002056 Domain of unknown function DUF59; Region: DUF59; cl00941 883062002057 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 883062002058 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 883062002059 Walker A motif; other site 883062002060 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 883062002061 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062002062 active site 883062002063 DNA binding site [nucleotide binding] 883062002064 Int/Topo IB signature motif; other site 883062002065 Methyltransferase domain; Region: Methyltransf_26; pfam13659 883062002066 Restriction endonuclease XhoI; Region: XhoI; pfam04555 883062002067 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 883062002068 GIY-YIG motif/motif A; other site 883062002069 putative active site [active] 883062002070 putative metal binding site [ion binding]; other site 883062002071 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 883062002072 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 883062002073 Helix-turn-helix domain; Region: HTH_17; pfam12728 883062002074 glutamine synthetase, type I; Region: GlnA; TIGR00653 883062002075 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 883062002076 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 883062002077 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 883062002078 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 883062002079 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 883062002080 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 883062002081 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 883062002082 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 883062002083 hypothetical protein; Provisional; Region: PRK07907 883062002084 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 883062002085 active site 883062002086 metal binding site [ion binding]; metal-binding site 883062002087 dimer interface [polypeptide binding]; other site 883062002088 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062002089 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 883062002090 Walker A/P-loop; other site 883062002091 ATP binding site [chemical binding]; other site 883062002092 Q-loop/lid; other site 883062002093 ABC transporter signature motif; other site 883062002094 Walker B; other site 883062002095 D-loop; other site 883062002096 H-loop/switch region; other site 883062002097 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 883062002098 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 883062002099 Uncharacterized conserved protein [Function unknown]; Region: COG1615 883062002100 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 883062002101 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 883062002102 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 883062002103 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 883062002104 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 883062002105 Acyltransferase family; Region: Acyl_transf_3; pfam01757 883062002106 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 883062002107 substrate binding site; other site 883062002108 dimer interface; other site 883062002109 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 883062002110 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 883062002111 NAD(P) binding site [chemical binding]; other site 883062002112 active site 883062002113 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 883062002114 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 883062002115 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 883062002116 Walker A/P-loop; other site 883062002117 ATP binding site [chemical binding]; other site 883062002118 Q-loop/lid; other site 883062002119 ABC transporter signature motif; other site 883062002120 Walker B; other site 883062002121 D-loop; other site 883062002122 H-loop/switch region; other site 883062002123 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 883062002124 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 883062002125 Coenzyme A binding pocket [chemical binding]; other site 883062002126 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 883062002127 putative active site [active] 883062002128 catalytic residue [active] 883062002129 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 883062002130 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 883062002131 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062002132 ATP binding site [chemical binding]; other site 883062002133 putative Mg++ binding site [ion binding]; other site 883062002134 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062002135 nucleotide binding region [chemical binding]; other site 883062002136 ATP-binding site [chemical binding]; other site 883062002137 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 883062002138 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 883062002139 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 883062002140 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 883062002141 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 883062002142 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 883062002143 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062002144 catalytic residue [active] 883062002145 enolase; Provisional; Region: eno; PRK00077 883062002146 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 883062002147 dimer interface [polypeptide binding]; other site 883062002148 metal binding site [ion binding]; metal-binding site 883062002149 substrate binding pocket [chemical binding]; other site 883062002150 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 883062002151 Septum formation initiator; Region: DivIC; pfam04977 883062002152 Protein of unknown function (DUF501); Region: DUF501; pfam04417 883062002153 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 883062002154 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 883062002155 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 883062002156 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 883062002157 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 883062002158 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 883062002159 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 883062002160 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 883062002161 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 883062002162 V-type ATP synthase subunit E; Provisional; Region: PRK01558 883062002163 Haemolysin-III related; Region: HlyIII; pfam03006 883062002164 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 883062002165 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 883062002166 PAS fold; Region: PAS_4; pfam08448 883062002167 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 883062002168 Histidine kinase; Region: HisKA_2; pfam07568 883062002169 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062002170 ATP binding site [chemical binding]; other site 883062002171 Mg2+ binding site [ion binding]; other site 883062002172 G-X-G motif; other site 883062002173 Transcription factor WhiB; Region: Whib; pfam02467 883062002174 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 883062002175 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 883062002176 Transcription factor WhiB; Region: Whib; pfam02467 883062002177 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 883062002178 active site 883062002179 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 883062002180 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 883062002181 Predicted integral membrane protein [Function unknown]; Region: COG5617 883062002182 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 883062002183 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 883062002184 Eukaryotic phosphomannomutase; Region: PMM; cl17107 883062002185 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 883062002186 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062002187 active site 883062002188 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 883062002189 Catalytic site [active] 883062002190 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 883062002191 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 883062002192 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 883062002193 dimerization interface [polypeptide binding]; other site 883062002194 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 883062002195 dimer interface [polypeptide binding]; other site 883062002196 phosphorylation site [posttranslational modification] 883062002197 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062002198 ATP binding site [chemical binding]; other site 883062002199 Mg2+ binding site [ion binding]; other site 883062002200 G-X-G motif; other site 883062002201 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 883062002202 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062002203 active site 883062002204 phosphorylation site [posttranslational modification] 883062002205 intermolecular recognition site; other site 883062002206 dimerization interface [polypeptide binding]; other site 883062002207 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 883062002208 DNA binding site [nucleotide binding] 883062002209 glycogen branching enzyme; Provisional; Region: PRK05402 883062002210 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 883062002211 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 883062002212 active site 883062002213 catalytic site [active] 883062002214 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 883062002215 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 883062002216 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 883062002217 homotrimer interaction site [polypeptide binding]; other site 883062002218 zinc binding site [ion binding]; other site 883062002219 CDP-binding sites; other site 883062002220 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 883062002221 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 883062002222 ABC-ATPase subunit interface; other site 883062002223 dimer interface [polypeptide binding]; other site 883062002224 putative PBP binding regions; other site 883062002225 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 883062002226 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 883062002227 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 883062002228 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 883062002229 metal binding site [ion binding]; metal-binding site 883062002230 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 883062002231 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 883062002232 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 883062002233 homodimer interface [polypeptide binding]; other site 883062002234 NADP binding site [chemical binding]; other site 883062002235 substrate binding site [chemical binding]; other site 883062002236 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 883062002237 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 883062002238 RNA binding site [nucleotide binding]; other site 883062002239 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 883062002240 RNA binding site [nucleotide binding]; other site 883062002241 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 883062002242 RNA binding site [nucleotide binding]; other site 883062002243 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 883062002244 RNA binding site [nucleotide binding]; other site 883062002245 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 883062002246 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 883062002247 CoA-binding site [chemical binding]; other site 883062002248 ATP-binding [chemical binding]; other site 883062002249 excinuclease ABC subunit B; Provisional; Region: PRK05298 883062002250 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062002251 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062002252 nucleotide binding region [chemical binding]; other site 883062002253 ATP-binding site [chemical binding]; other site 883062002254 Ultra-violet resistance protein B; Region: UvrB; pfam12344 883062002255 UvrB/uvrC motif; Region: UVR; pfam02151 883062002256 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 883062002257 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 883062002258 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 883062002259 domain interfaces; other site 883062002260 active site 883062002261 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 883062002262 dimer interface [polypeptide binding]; other site 883062002263 ADP-ribose binding site [chemical binding]; other site 883062002264 active site 883062002265 nudix motif; other site 883062002266 metal binding site [ion binding]; metal-binding site 883062002267 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 883062002268 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062002269 active site 883062002270 phosphorylation site [posttranslational modification] 883062002271 intermolecular recognition site; other site 883062002272 dimerization interface [polypeptide binding]; other site 883062002273 ANTAR domain; Region: ANTAR; pfam03861 883062002274 DNA polymerase I; Provisional; Region: PRK05755 883062002275 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 883062002276 active site 883062002277 metal binding site 1 [ion binding]; metal-binding site 883062002278 putative 5' ssDNA interaction site; other site 883062002279 metal binding site 3; metal-binding site 883062002280 metal binding site 2 [ion binding]; metal-binding site 883062002281 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 883062002282 putative DNA binding site [nucleotide binding]; other site 883062002283 putative metal binding site [ion binding]; other site 883062002284 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 883062002285 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 883062002286 active site 883062002287 DNA binding site [nucleotide binding] 883062002288 catalytic site [active] 883062002289 Uncharacterized conserved protein [Function unknown]; Region: COG0327 883062002290 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 883062002291 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 883062002292 dimer interface [polypeptide binding]; other site 883062002293 ADP-ribose binding site [chemical binding]; other site 883062002294 active site 883062002295 nudix motif; other site 883062002296 metal binding site [ion binding]; metal-binding site 883062002297 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 883062002298 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 883062002299 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 883062002300 active site 883062002301 catalytic site [active] 883062002302 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 883062002303 Int/Topo IB signature motif; other site 883062002304 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 883062002305 conserved cys residue [active] 883062002306 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 883062002307 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 883062002308 hinge; other site 883062002309 active site 883062002310 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 883062002311 propionate/acetate kinase; Provisional; Region: PRK12379 883062002312 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 883062002313 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 883062002314 hypothetical protein; Provisional; Region: PRK13663 883062002315 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 883062002316 Protein of unknown function (DUF1294); Region: DUF1294; cl01311 883062002317 Helix-turn-helix domain; Region: HTH_17; cl17695 883062002318 GMP synthase; Reviewed; Region: guaA; PRK00074 883062002319 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 883062002320 AMP/PPi binding site [chemical binding]; other site 883062002321 candidate oxyanion hole; other site 883062002322 catalytic triad [active] 883062002323 potential glutamine specificity residues [chemical binding]; other site 883062002324 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 883062002325 ATP Binding subdomain [chemical binding]; other site 883062002326 Ligand Binding sites [chemical binding]; other site 883062002327 Dimerization subdomain; other site 883062002328 putative phosphoketolase; Provisional; Region: PRK05261 883062002329 XFP N-terminal domain; Region: XFP_N; pfam09364 883062002330 XFP C-terminal domain; Region: XFP_C; pfam09363 883062002331 Phosphate transporter family; Region: PHO4; pfam01384 883062002332 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 883062002333 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 883062002334 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062002335 active site 883062002336 phosphorylation site [posttranslational modification] 883062002337 intermolecular recognition site; other site 883062002338 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 883062002339 DNA binding residues [nucleotide binding] 883062002340 dimerization interface [polypeptide binding]; other site 883062002341 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 883062002342 Histidine kinase; Region: HisKA_3; pfam07730 883062002343 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 883062002344 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 883062002345 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 883062002346 Walker A/P-loop; other site 883062002347 ATP binding site [chemical binding]; other site 883062002348 Q-loop/lid; other site 883062002349 ABC transporter signature motif; other site 883062002350 Walker B; other site 883062002351 D-loop; other site 883062002352 H-loop/switch region; other site 883062002353 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 883062002354 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 883062002355 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 883062002356 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 883062002357 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 883062002358 Divergent AAA domain; Region: AAA_4; pfam04326 883062002359 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 883062002360 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 883062002361 Helix-turn-helix domain; Region: HTH_38; pfam13936 883062002362 Integrase core domain; Region: rve; pfam00665 883062002363 MobA/MobL family; Region: MobA_MobL; pfam03389 883062002364 Transposase; Region: HTH_Tnp_1; pfam01527 883062002365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 883062002366 Integrase core domain; Region: rve; pfam00665 883062002367 Integrase core domain; Region: rve_3; pfam13683 883062002368 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 883062002369 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 883062002370 Isochorismatase family; Region: Isochorismatase; pfam00857 883062002371 catalytic triad [active] 883062002372 metal binding site [ion binding]; metal-binding site 883062002373 conserved cis-peptide bond; other site 883062002374 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 883062002375 dimer interface [polypeptide binding]; other site 883062002376 xanthine permease; Region: pbuX; TIGR03173 883062002377 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062002378 active site 883062002379 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 883062002380 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 883062002381 active site 883062002382 catalytic triad [active] 883062002383 oxyanion hole [active] 883062002384 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 883062002385 Part of AAA domain; Region: AAA_19; pfam13245 883062002386 Family description; Region: UvrD_C_2; pfam13538 883062002387 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 883062002388 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 883062002389 FtsX-like permease family; Region: FtsX; pfam02687 883062002390 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 883062002391 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 883062002392 Walker A/P-loop; other site 883062002393 ATP binding site [chemical binding]; other site 883062002394 Q-loop/lid; other site 883062002395 ABC transporter signature motif; other site 883062002396 Walker B; other site 883062002397 D-loop; other site 883062002398 H-loop/switch region; other site 883062002399 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 883062002400 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 883062002401 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 883062002402 RNA binding surface [nucleotide binding]; other site 883062002403 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 883062002404 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 883062002405 catalytic triad [active] 883062002406 catalytic triad [active] 883062002407 oxyanion hole [active] 883062002408 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 883062002409 catalytic core [active] 883062002410 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 883062002411 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 883062002412 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 883062002413 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 883062002414 motif 1; other site 883062002415 active site 883062002416 motif 2; other site 883062002417 motif 3; other site 883062002418 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 883062002419 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 883062002420 YceG-like family; Region: YceG; pfam02618 883062002421 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 883062002422 dimerization interface [polypeptide binding]; other site 883062002423 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 883062002424 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 883062002425 Tetramer interface [polypeptide binding]; other site 883062002426 active site 883062002427 FMN-binding site [chemical binding]; other site 883062002428 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 883062002429 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 883062002430 ADP binding site [chemical binding]; other site 883062002431 magnesium binding site [ion binding]; other site 883062002432 putative shikimate binding site; other site 883062002433 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 883062002434 active site 883062002435 dimer interface [polypeptide binding]; other site 883062002436 metal binding site [ion binding]; metal-binding site 883062002437 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 883062002438 Dehydroquinase class II; Region: DHquinase_II; pfam01220 883062002439 trimer interface [polypeptide binding]; other site 883062002440 active site 883062002441 dimer interface [polypeptide binding]; other site 883062002442 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 883062002443 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062002444 active site 883062002445 phosphorylation site [posttranslational modification] 883062002446 intermolecular recognition site; other site 883062002447 dimerization interface [polypeptide binding]; other site 883062002448 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 883062002449 DNA binding residues [nucleotide binding] 883062002450 dimerization interface [polypeptide binding]; other site 883062002451 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 883062002452 CTP synthetase; Validated; Region: pyrG; PRK05380 883062002453 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 883062002454 Catalytic site [active] 883062002455 active site 883062002456 UTP binding site [chemical binding]; other site 883062002457 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 883062002458 active site 883062002459 putative oxyanion hole; other site 883062002460 catalytic triad [active] 883062002461 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 883062002462 FeS assembly protein SufB; Region: sufB; TIGR01980 883062002463 FeS assembly protein SufD; Region: sufD; TIGR01981 883062002464 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 883062002465 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 883062002466 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 883062002467 Walker A/P-loop; other site 883062002468 ATP binding site [chemical binding]; other site 883062002469 Q-loop/lid; other site 883062002470 ABC transporter signature motif; other site 883062002471 Walker B; other site 883062002472 D-loop; other site 883062002473 H-loop/switch region; other site 883062002474 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 883062002475 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 883062002476 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 883062002477 catalytic residue [active] 883062002478 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 883062002479 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 883062002480 trimerization site [polypeptide binding]; other site 883062002481 active site 883062002482 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 883062002483 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 883062002484 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 883062002485 ligand binding site; other site 883062002486 oligomer interface; other site 883062002487 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 883062002488 dimer interface [polypeptide binding]; other site 883062002489 N-terminal domain interface [polypeptide binding]; other site 883062002490 sulfate 1 binding site; other site 883062002491 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 883062002492 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 883062002493 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 883062002494 RNA methyltransferase, RsmE family; Region: TIGR00046 883062002495 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 883062002496 nucleotide binding site/active site [active] 883062002497 HIT family signature motif; other site 883062002498 catalytic residue [active] 883062002499 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 883062002500 PhoH-like protein; Region: PhoH; pfam02562 883062002501 metal-binding heat shock protein; Provisional; Region: PRK00016 883062002502 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 883062002503 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 883062002504 Transporter associated domain; Region: CorC_HlyC; smart01091 883062002505 GTPase Era; Reviewed; Region: era; PRK00089 883062002506 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 883062002507 G1 box; other site 883062002508 GTP/Mg2+ binding site [chemical binding]; other site 883062002509 Switch I region; other site 883062002510 G2 box; other site 883062002511 Switch II region; other site 883062002512 G3 box; other site 883062002513 G4 box; other site 883062002514 G5 box; other site 883062002515 KH domain; Region: KH_2; pfam07650 883062002516 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 883062002517 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 883062002518 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 883062002519 acyl-activating enzyme (AAE) consensus motif; other site 883062002520 putative AMP binding site [chemical binding]; other site 883062002521 putative active site [active] 883062002522 putative CoA binding site [chemical binding]; other site 883062002523 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 883062002524 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 883062002525 ligand binding site [chemical binding]; other site 883062002526 homodimer interface [polypeptide binding]; other site 883062002527 NAD(P) binding site [chemical binding]; other site 883062002528 trimer interface B [polypeptide binding]; other site 883062002529 trimer interface A [polypeptide binding]; other site 883062002530 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 883062002531 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 883062002532 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 883062002533 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 883062002534 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 883062002535 5S rRNA interface [nucleotide binding]; other site 883062002536 CTC domain interface [polypeptide binding]; other site 883062002537 L16 interface [polypeptide binding]; other site 883062002538 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 883062002539 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 883062002540 homodimer interface [polypeptide binding]; other site 883062002541 substrate-cofactor binding pocket; other site 883062002542 catalytic residue [active] 883062002543 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 883062002544 UPF0126 domain; Region: UPF0126; pfam03458 883062002545 Predicted membrane protein [Function unknown]; Region: COG2860 883062002546 UPF0126 domain; Region: UPF0126; pfam03458 883062002547 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 883062002548 GTP-binding protein LepA; Provisional; Region: PRK05433 883062002549 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 883062002550 G1 box; other site 883062002551 putative GEF interaction site [polypeptide binding]; other site 883062002552 GTP/Mg2+ binding site [chemical binding]; other site 883062002553 Switch I region; other site 883062002554 G2 box; other site 883062002555 G3 box; other site 883062002556 Switch II region; other site 883062002557 G4 box; other site 883062002558 G5 box; other site 883062002559 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 883062002560 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 883062002561 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 883062002562 coproporphyrinogen III oxidase; Validated; Region: PRK05628 883062002563 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 883062002564 FeS/SAM binding site; other site 883062002565 HemN C-terminal domain; Region: HemN_C; pfam06969 883062002566 Predicted membrane protein [Function unknown]; Region: COG2364 883062002567 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 883062002568 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062002569 non-specific DNA binding site [nucleotide binding]; other site 883062002570 salt bridge; other site 883062002571 sequence-specific DNA binding site [nucleotide binding]; other site 883062002572 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062002573 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062002574 homodimer interface [polypeptide binding]; other site 883062002575 catalytic residue [active] 883062002576 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 883062002577 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 883062002578 G1 box; other site 883062002579 putative GEF interaction site [polypeptide binding]; other site 883062002580 GTP/Mg2+ binding site [chemical binding]; other site 883062002581 Switch I region; other site 883062002582 G2 box; other site 883062002583 G3 box; other site 883062002584 Switch II region; other site 883062002585 G4 box; other site 883062002586 G5 box; other site 883062002587 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 883062002588 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 883062002589 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 883062002590 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 883062002591 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 883062002592 active site 883062002593 dimer interface [polypeptide binding]; other site 883062002594 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 883062002595 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 883062002596 active site 883062002597 FMN binding site [chemical binding]; other site 883062002598 substrate binding site [chemical binding]; other site 883062002599 3Fe-4S cluster binding site [ion binding]; other site 883062002600 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 883062002601 domain interface; other site 883062002602 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 883062002603 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 883062002604 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 883062002605 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 883062002606 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 883062002607 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 883062002608 Walker A/P-loop; other site 883062002609 ATP binding site [chemical binding]; other site 883062002610 Q-loop/lid; other site 883062002611 ABC transporter signature motif; other site 883062002612 Walker B; other site 883062002613 D-loop; other site 883062002614 H-loop/switch region; other site 883062002615 Predicted amidohydrolase [General function prediction only]; Region: COG0388 883062002616 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 883062002617 putative active site [active] 883062002618 catalytic triad [active] 883062002619 putative dimer interface [polypeptide binding]; other site 883062002620 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 883062002621 Sel1-like repeats; Region: SEL1; smart00671 883062002622 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 883062002623 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 883062002624 active site 883062002625 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 883062002626 Transposase; Region: DDE_Tnp_ISL3; pfam01610 883062002627 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 883062002628 Uncharacterized conserved protein [Function unknown]; Region: COG3410 883062002629 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 883062002630 Predicted permeases [General function prediction only]; Region: RarD; COG2962 883062002631 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 883062002632 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 883062002633 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 883062002634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 883062002635 S-adenosylmethionine binding site [chemical binding]; other site 883062002636 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 883062002637 catalytic core [active] 883062002638 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 883062002639 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 883062002640 THF binding site; other site 883062002641 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 883062002642 substrate binding site [chemical binding]; other site 883062002643 THF binding site; other site 883062002644 zinc-binding site [ion binding]; other site 883062002645 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 883062002646 FAD binding site [chemical binding]; other site 883062002647 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 883062002648 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 883062002649 metal binding triad; other site 883062002650 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 883062002651 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 883062002652 metal binding triad; other site 883062002653 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 883062002654 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 883062002655 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 883062002656 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 883062002657 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 883062002658 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 883062002659 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 883062002660 dihydroorotase; Validated; Region: pyrC; PRK09357 883062002661 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 883062002662 active site 883062002663 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 883062002664 active site 883062002665 dimer interface [polypeptide binding]; other site 883062002666 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 883062002667 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 883062002668 FAD binding pocket [chemical binding]; other site 883062002669 FAD binding motif [chemical binding]; other site 883062002670 phosphate binding motif [ion binding]; other site 883062002671 beta-alpha-beta structure motif; other site 883062002672 NAD binding pocket [chemical binding]; other site 883062002673 Iron coordination center [ion binding]; other site 883062002674 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 883062002675 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 883062002676 heterodimer interface [polypeptide binding]; other site 883062002677 active site 883062002678 FMN binding site [chemical binding]; other site 883062002679 homodimer interface [polypeptide binding]; other site 883062002680 substrate binding site [chemical binding]; other site 883062002681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062002682 active site 883062002683 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 883062002684 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 883062002685 DNA binding residues [nucleotide binding] 883062002686 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 883062002687 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 883062002688 catalytic Zn binding site [ion binding]; other site 883062002689 NAD(P) binding site [chemical binding]; other site 883062002690 structural Zn binding site [ion binding]; other site 883062002691 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062002692 Walker A/P-loop; other site 883062002693 ATP binding site [chemical binding]; other site 883062002694 Q-loop/lid; other site 883062002695 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062002696 ABC transporter signature motif; other site 883062002697 Walker B; other site 883062002698 D-loop; other site 883062002699 H-loop/switch region; other site 883062002700 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062002701 AAA domain; Region: AAA_21; pfam13304 883062002702 Walker A/P-loop; other site 883062002703 ATP binding site [chemical binding]; other site 883062002704 Q-loop/lid; other site 883062002705 ABC transporter signature motif; other site 883062002706 Walker B; other site 883062002707 D-loop; other site 883062002708 H-loop/switch region; other site 883062002709 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 883062002710 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 883062002711 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 883062002712 classical (c) SDRs; Region: SDR_c; cd05233 883062002713 NAD(P) binding site [chemical binding]; other site 883062002714 active site 883062002715 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 883062002716 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 883062002717 minor groove reading motif; other site 883062002718 helix-hairpin-helix signature motif; other site 883062002719 substrate binding pocket [chemical binding]; other site 883062002720 active site 883062002721 Predicted transcriptional regulators [Transcription]; Region: COG1695 883062002722 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 883062002723 Membrane transport protein; Region: Mem_trans; cl09117 883062002724 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 883062002725 HipA N-terminal domain; Region: Couple_hipA; pfam13657 883062002726 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 883062002727 HipA-like N-terminal domain; Region: HipA_N; pfam07805 883062002728 HipA-like C-terminal domain; Region: HipA_C; pfam07804 883062002729 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 883062002730 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062002731 non-specific DNA binding site [nucleotide binding]; other site 883062002732 salt bridge; other site 883062002733 sequence-specific DNA binding site [nucleotide binding]; other site 883062002734 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 883062002735 S-adenosylmethionine binding site [chemical binding]; other site 883062002736 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3226 883062002737 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 883062002738 Domain of unknown function (DUF4234); Region: DUF4234; pfam14018 883062002739 Transcriptional regulator [Transcription]; Region: LysR; COG0583 883062002740 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 883062002741 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 883062002742 dimerization interface [polypeptide binding]; other site 883062002743 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 883062002744 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 883062002745 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062002746 motif II; other site 883062002747 YjeF-related protein N-terminus; Region: YjeF_N; cl00318 883062002748 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 883062002749 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 883062002750 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 883062002751 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 883062002752 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 883062002753 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 883062002754 catalytic tetrad [active] 883062002755 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 883062002756 active site 883062002757 Predicted transcriptional regulator [Transcription]; Region: COG2378 883062002758 WYL domain; Region: WYL; pfam13280 883062002759 DEAD-like helicases superfamily; Region: DEXDc; smart00487 883062002760 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062002761 ATP binding site [chemical binding]; other site 883062002762 putative Mg++ binding site [ion binding]; other site 883062002763 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062002764 nucleotide binding region [chemical binding]; other site 883062002765 ATP-binding site [chemical binding]; other site 883062002766 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 883062002767 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 883062002768 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 883062002769 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062002770 motif II; other site 883062002771 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 883062002772 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 883062002773 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062002774 non-specific DNA binding site [nucleotide binding]; other site 883062002775 salt bridge; other site 883062002776 sequence-specific DNA binding site [nucleotide binding]; other site 883062002777 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 883062002778 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 883062002779 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 883062002780 DNA binding residues [nucleotide binding] 883062002781 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 883062002782 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 883062002783 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 883062002784 phosphopeptide binding site; other site 883062002785 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 883062002786 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 883062002787 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 883062002788 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 883062002789 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 883062002790 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 883062002791 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 883062002792 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 883062002793 homodimer interface [polypeptide binding]; other site 883062002794 putative metal binding site [ion binding]; other site 883062002795 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 883062002796 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 883062002797 substrate binding site [chemical binding]; other site 883062002798 hexamer interface [polypeptide binding]; other site 883062002799 metal binding site [ion binding]; metal-binding site 883062002800 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 883062002801 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 883062002802 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 883062002803 substrate binding site [chemical binding]; other site 883062002804 active site 883062002805 catalytic residues [active] 883062002806 heterodimer interface [polypeptide binding]; other site 883062002807 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 883062002808 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 883062002809 active site 883062002810 ribulose/triose binding site [chemical binding]; other site 883062002811 phosphate binding site [ion binding]; other site 883062002812 substrate (anthranilate) binding pocket [chemical binding]; other site 883062002813 product (indole) binding pocket [chemical binding]; other site 883062002814 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 883062002815 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062002816 catalytic residue [active] 883062002817 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 883062002818 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 883062002819 CMP-binding site; other site 883062002820 The sites determining sugar specificity; other site 883062002821 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 883062002822 G1 box; other site 883062002823 GTP/Mg2+ binding site [chemical binding]; other site 883062002824 Switch I region; other site 883062002825 G2 box; other site 883062002826 Switch II region; other site 883062002827 G3 box; other site 883062002828 G4 box; other site 883062002829 G5 box; other site 883062002830 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 883062002831 G1 box; other site 883062002832 GTP/Mg2+ binding site [chemical binding]; other site 883062002833 Switch I region; other site 883062002834 G2 box; other site 883062002835 G3 box; other site 883062002836 Switch II region; other site 883062002837 G4 box; other site 883062002838 G5 box; other site 883062002839 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 883062002840 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 883062002841 RNA binding surface [nucleotide binding]; other site 883062002842 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 883062002843 active site 883062002844 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 883062002845 amphipathic channel; other site 883062002846 Asn-Pro-Ala signature motifs; other site 883062002847 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 883062002848 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 883062002849 purine monophosphate binding site [chemical binding]; other site 883062002850 dimer interface [polypeptide binding]; other site 883062002851 putative catalytic residues [active] 883062002852 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 883062002853 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 883062002854 CoA binding domain; Region: CoA_binding; smart00881 883062002855 CoA-ligase; Region: Ligase_CoA; pfam00549 883062002856 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 883062002857 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 883062002858 CoA-ligase; Region: Ligase_CoA; pfam00549 883062002859 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062002860 active site 883062002861 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 883062002862 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 883062002863 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062002864 Walker A motif; other site 883062002865 ATP binding site [chemical binding]; other site 883062002866 Walker B motif; other site 883062002867 arginine finger; other site 883062002868 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 883062002869 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 883062002870 RuvA N terminal domain; Region: RuvA_N; pfam01330 883062002871 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 883062002872 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 883062002873 active site 883062002874 putative DNA-binding cleft [nucleotide binding]; other site 883062002875 dimer interface [polypeptide binding]; other site 883062002876 hypothetical protein; Validated; Region: PRK00110 883062002877 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062002878 sugar binding site [chemical binding]; other site 883062002879 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 883062002880 Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948 883062002881 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 883062002882 active site 883062002883 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 883062002884 thiS-thiF/thiG interaction site; other site 883062002885 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 883062002886 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 883062002887 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 883062002888 active site 883062002889 dimer interface [polypeptide binding]; other site 883062002890 motif 1; other site 883062002891 motif 2; other site 883062002892 motif 3; other site 883062002893 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 883062002894 anticodon binding site; other site 883062002895 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 883062002896 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 883062002897 large tegument protein UL36; Provisional; Region: PHA03247 883062002898 PAC2 family; Region: PAC2; pfam09754 883062002899 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 883062002900 Phosphotransferase enzyme family; Region: APH; pfam01636 883062002901 Fructosamine kinase; Region: Fructosamin_kin; cl17579 883062002902 chaperone protein DnaJ; Provisional; Region: PRK14278 883062002903 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 883062002904 HSP70 interaction site [polypeptide binding]; other site 883062002905 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 883062002906 Zn binding sites [ion binding]; other site 883062002907 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 883062002908 dimer interface [polypeptide binding]; other site 883062002909 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 883062002910 HTH domain; Region: HTH_11; pfam08279 883062002911 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 883062002912 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 883062002913 TPP-binding site [chemical binding]; other site 883062002914 dimer interface [polypeptide binding]; other site 883062002915 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 883062002916 PYR/PP interface [polypeptide binding]; other site 883062002917 dimer interface [polypeptide binding]; other site 883062002918 TPP binding site [chemical binding]; other site 883062002919 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 883062002920 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 883062002921 putative active site [active] 883062002922 transaldolase; Provisional; Region: PRK03903 883062002923 catalytic residue [active] 883062002924 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 883062002925 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 883062002926 Bacterial transglutaminase-like cysteine proteinase BTLCP; Region: BTLCP; cl17596 883062002927 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 883062002928 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 883062002929 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062002930 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 883062002931 active site 883062002932 motif I; other site 883062002933 motif II; other site 883062002934 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 883062002935 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 883062002936 tetramer (dimer of dimers) interface [polypeptide binding]; other site 883062002937 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 883062002938 NAD binding site [chemical binding]; other site 883062002939 dimer interface [polypeptide binding]; other site 883062002940 substrate binding site [chemical binding]; other site 883062002941 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 883062002942 triosephosphate isomerase; Provisional; Region: PRK14567 883062002943 substrate binding site [chemical binding]; other site 883062002944 dimer interface [polypeptide binding]; other site 883062002945 catalytic triad [active] 883062002946 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 883062002947 Phosphoglycerate kinase; Region: PGK; pfam00162 883062002948 substrate binding site [chemical binding]; other site 883062002949 hinge regions; other site 883062002950 ADP binding site [chemical binding]; other site 883062002951 catalytic site [active] 883062002952 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 883062002953 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 883062002954 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 883062002955 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 883062002956 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 883062002957 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 883062002958 shikimate binding site; other site 883062002959 NAD(P) binding site [chemical binding]; other site 883062002960 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 883062002961 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 883062002962 GIY-YIG motif/motif A; other site 883062002963 active site 883062002964 catalytic site [active] 883062002965 putative DNA binding site [nucleotide binding]; other site 883062002966 metal binding site [ion binding]; metal-binding site 883062002967 UvrB/uvrC motif; Region: UVR; pfam02151 883062002968 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 883062002969 Helix-hairpin-helix motif; Region: HHH; pfam00633 883062002970 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 883062002971 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 883062002972 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 883062002973 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 883062002974 FtsX-like permease family; Region: FtsX; pfam02687 883062002975 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 883062002976 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062002977 active site 883062002978 phosphorylation site [posttranslational modification] 883062002979 intermolecular recognition site; other site 883062002980 dimerization interface [polypeptide binding]; other site 883062002981 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 883062002982 DNA binding site [nucleotide binding] 883062002983 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 883062002984 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 883062002985 dimerization interface [polypeptide binding]; other site 883062002986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 883062002987 dimer interface [polypeptide binding]; other site 883062002988 phosphorylation site [posttranslational modification] 883062002989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062002990 ATP binding site [chemical binding]; other site 883062002991 Mg2+ binding site [ion binding]; other site 883062002992 G-X-G motif; other site 883062002993 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 883062002994 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 883062002995 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 883062002996 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 883062002997 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 883062002998 UDP-glucose 4-epimerase; Region: PLN02240 883062002999 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 883062003000 NAD binding site [chemical binding]; other site 883062003001 homodimer interface [polypeptide binding]; other site 883062003002 active site 883062003003 substrate binding site [chemical binding]; other site 883062003004 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 883062003005 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 883062003006 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 883062003007 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 883062003008 Phosphotransferase enzyme family; Region: APH; pfam01636 883062003009 active site 883062003010 substrate binding site [chemical binding]; other site 883062003011 ATP binding site [chemical binding]; other site 883062003012 MarR family; Region: MarR_2; pfam12802 883062003013 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 883062003014 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 883062003015 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 883062003016 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 883062003017 nucleotide binding site [chemical binding]; other site 883062003018 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 883062003019 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 883062003020 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 883062003021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062003022 dimer interface [polypeptide binding]; other site 883062003023 conserved gate region; other site 883062003024 putative PBP binding loops; other site 883062003025 ABC-ATPase subunit interface; other site 883062003026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062003027 dimer interface [polypeptide binding]; other site 883062003028 conserved gate region; other site 883062003029 ABC-ATPase subunit interface; other site 883062003030 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 883062003031 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 883062003032 anthranilate synthase component I; Provisional; Region: PRK13571 883062003033 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 883062003034 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 883062003035 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 883062003036 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 883062003037 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 883062003038 substrate binding site [chemical binding]; other site 883062003039 glutamase interaction surface [polypeptide binding]; other site 883062003040 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 883062003041 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 883062003042 FeS/SAM binding site; other site 883062003043 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 883062003044 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 883062003045 ribosome recycling factor; Reviewed; Region: frr; PRK00083 883062003046 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 883062003047 hinge region; other site 883062003048 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 883062003049 putative nucleotide binding site [chemical binding]; other site 883062003050 uridine monophosphate binding site [chemical binding]; other site 883062003051 homohexameric interface [polypeptide binding]; other site 883062003052 elongation factor Ts; Provisional; Region: tsf; PRK09377 883062003053 UBA/TS-N domain; Region: UBA; pfam00627 883062003054 Elongation factor TS; Region: EF_TS; pfam00889 883062003055 Elongation factor TS; Region: EF_TS; pfam00889 883062003056 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 883062003057 rRNA interaction site [nucleotide binding]; other site 883062003058 S8 interaction site; other site 883062003059 putative laminin-1 binding site; other site 883062003060 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 883062003061 active site 883062003062 catalytic residues [active] 883062003063 metal binding site [ion binding]; metal-binding site 883062003064 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 883062003065 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062003066 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 883062003067 acyl-activating enzyme (AAE) consensus motif; other site 883062003068 putative AMP binding site [chemical binding]; other site 883062003069 putative active site [active] 883062003070 putative CoA binding site [chemical binding]; other site 883062003071 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 883062003072 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 883062003073 active site 883062003074 isocitrate dehydrogenase; Validated; Region: PRK08299 883062003075 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 883062003076 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 883062003077 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 883062003078 acyl-activating enzyme (AAE) consensus motif; other site 883062003079 putative AMP binding site [chemical binding]; other site 883062003080 putative active site [active] 883062003081 putative CoA binding site [chemical binding]; other site 883062003082 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 883062003083 Peptidase family M23; Region: Peptidase_M23; pfam01551 883062003084 UGMP family protein; Validated; Region: PRK09604 883062003085 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 883062003086 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 883062003087 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 883062003088 Coenzyme A binding pocket [chemical binding]; other site 883062003089 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 883062003090 Glycoprotease family; Region: Peptidase_M22; pfam00814 883062003091 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 883062003092 hypothetical protein; Reviewed; Region: PRK07914 883062003093 Competence protein; Region: Competence; pfam03772 883062003094 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 883062003095 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 883062003096 Helix-hairpin-helix motif; Region: HHH; pfam00633 883062003097 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 883062003098 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 883062003099 active site 883062003100 HIGH motif; other site 883062003101 nucleotide binding site [chemical binding]; other site 883062003102 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 883062003103 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 883062003104 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 883062003105 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 883062003106 active site 883062003107 KMSKS motif; other site 883062003108 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 883062003109 tRNA binding surface [nucleotide binding]; other site 883062003110 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 883062003111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 883062003112 substrate binding pocket [chemical binding]; other site 883062003113 membrane-bound complex binding site; other site 883062003114 hinge residues; other site 883062003115 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 883062003116 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 883062003117 Cl binding site [ion binding]; other site 883062003118 oligomer interface [polypeptide binding]; other site 883062003119 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 883062003120 catalytic core [active] 883062003121 Carboxypeptidase C (cathepsin A) [Amino acid transport and metabolism]; Region: COG2939 883062003122 Serine carboxypeptidase; Region: Peptidase_S10; cl08270 883062003123 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 883062003124 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 883062003125 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 883062003126 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 883062003127 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 883062003128 endonuclease IV; Provisional; Region: PRK01060 883062003129 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 883062003130 AP (apurinic/apyrimidinic) site pocket; other site 883062003131 DNA interaction; other site 883062003132 Metal-binding active site; metal-binding site 883062003133 Uncharacterized conserved protein [Function unknown]; Region: COG3189 883062003134 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 883062003135 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 883062003136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 883062003137 Coenzyme A binding pocket [chemical binding]; other site 883062003138 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 883062003139 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 883062003140 putative deacylase active site [active] 883062003141 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 883062003142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 883062003143 Coenzyme A binding pocket [chemical binding]; other site 883062003144 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 883062003145 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 883062003146 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 883062003147 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 883062003148 H+ Antiporter protein; Region: 2A0121; TIGR00900 883062003149 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 883062003150 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 883062003151 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 883062003152 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 883062003153 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 883062003154 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 883062003155 DNA binding site [nucleotide binding] 883062003156 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 883062003157 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 883062003158 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 883062003159 FMN binding site [chemical binding]; other site 883062003160 dimer interface [polypeptide binding]; other site 883062003161 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 883062003162 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 883062003163 active site 883062003164 catalytic site [active] 883062003165 Bacterial PH domain; Region: DUF304; pfam03703 883062003166 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 883062003167 catalytic core [active] 883062003168 Oligomerisation domain; Region: Oligomerisation; pfam02410 883062003169 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 883062003170 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 883062003171 Substrate binding site; other site 883062003172 Mg++ binding site; other site 883062003173 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 883062003174 active site 883062003175 substrate binding site [chemical binding]; other site 883062003176 CoA binding site [chemical binding]; other site 883062003177 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 883062003178 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 883062003179 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062003180 active site 883062003181 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 883062003182 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 883062003183 active site 883062003184 (T/H)XGH motif; other site 883062003185 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 883062003186 putative catalytic cysteine [active] 883062003187 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 883062003188 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 883062003189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062003190 catalytic residue [active] 883062003191 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 883062003192 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 883062003193 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 883062003194 Walker A/P-loop; other site 883062003195 ATP binding site [chemical binding]; other site 883062003196 Q-loop/lid; other site 883062003197 ABC transporter signature motif; other site 883062003198 Walker B; other site 883062003199 D-loop; other site 883062003200 H-loop/switch region; other site 883062003201 Predicted transcriptional regulators [Transcription]; Region: COG1725 883062003202 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 883062003203 DNA-binding site [nucleotide binding]; DNA binding site 883062003204 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 883062003205 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062003206 motif II; other site 883062003207 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 883062003208 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 883062003209 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 883062003210 Walker A/P-loop; other site 883062003211 ATP binding site [chemical binding]; other site 883062003212 Q-loop/lid; other site 883062003213 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 883062003214 ABC transporter signature motif; other site 883062003215 Walker B; other site 883062003216 D-loop; other site 883062003217 H-loop/switch region; other site 883062003218 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 883062003219 ATP-NAD kinase; Region: NAD_kinase; pfam01513 883062003220 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 883062003221 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 883062003222 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 883062003223 TrkA-N domain; Region: TrkA_N; pfam02254 883062003224 TrkA-C domain; Region: TrkA_C; pfam02080 883062003225 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 883062003226 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 883062003227 RNA binding surface [nucleotide binding]; other site 883062003228 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 883062003229 S-adenosylmethionine binding site [chemical binding]; other site 883062003230 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 883062003231 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062003232 active site 883062003233 motif I; other site 883062003234 motif II; other site 883062003235 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062003236 motif II; other site 883062003237 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 883062003238 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 883062003239 active site 883062003240 HIGH motif; other site 883062003241 dimer interface [polypeptide binding]; other site 883062003242 KMSKS motif; other site 883062003243 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 883062003244 RNA binding surface [nucleotide binding]; other site 883062003245 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 883062003246 Predicted membrane protein [Function unknown]; Region: COG4905 883062003247 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 883062003248 Zn2+ binding site [ion binding]; other site 883062003249 Mg2+ binding site [ion binding]; other site 883062003250 argininosuccinate lyase; Provisional; Region: PRK00855 883062003251 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 883062003252 active sites [active] 883062003253 tetramer interface [polypeptide binding]; other site 883062003254 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 883062003255 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 883062003256 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062003257 ATP binding site [chemical binding]; other site 883062003258 putative Mg++ binding site [ion binding]; other site 883062003259 Type I restriction and modification enzyme - subunit R C terminal; Region: EcoR124_C; pfam12008 883062003260 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 883062003261 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 883062003262 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 883062003263 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 883062003264 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 883062003265 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 883062003266 HsdM N-terminal domain; Region: HsdM_N; pfam12161 883062003267 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 883062003268 Methyltransferase domain; Region: Methyltransf_26; pfam13659 883062003269 Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111 883062003270 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 883062003271 GIY-YIG motif/motif A; other site 883062003272 putative active site [active] 883062003273 putative metal binding site [ion binding]; other site 883062003274 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 883062003275 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 883062003276 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 883062003277 Int/Topo IB signature motif; other site 883062003278 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 883062003279 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 883062003280 argininosuccinate synthase; Provisional; Region: PRK13820 883062003281 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 883062003282 ANP binding site [chemical binding]; other site 883062003283 Substrate Binding Site II [chemical binding]; other site 883062003284 Substrate Binding Site I [chemical binding]; other site 883062003285 arginine repressor; Provisional; Region: PRK03341 883062003286 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 883062003287 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 883062003288 ornithine carbamoyltransferase; Provisional; Region: PRK00779 883062003289 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 883062003290 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 883062003291 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 883062003292 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 883062003293 inhibitor-cofactor binding pocket; inhibition site 883062003294 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062003295 catalytic residue [active] 883062003296 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 883062003297 feedback inhibition sensing region; other site 883062003298 homohexameric interface [polypeptide binding]; other site 883062003299 nucleotide binding site [chemical binding]; other site 883062003300 N-acetyl-L-glutamate binding site [chemical binding]; other site 883062003301 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 883062003302 heterotetramer interface [polypeptide binding]; other site 883062003303 active site pocket [active] 883062003304 cleavage site 883062003305 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 883062003306 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 883062003307 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 883062003308 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 883062003309 putative tRNA-binding site [nucleotide binding]; other site 883062003310 B3/4 domain; Region: B3_4; pfam03483 883062003311 tRNA synthetase B5 domain; Region: B5; pfam03484 883062003312 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 883062003313 dimer interface [polypeptide binding]; other site 883062003314 motif 1; other site 883062003315 motif 3; other site 883062003316 motif 2; other site 883062003317 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 883062003318 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 883062003319 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 883062003320 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 883062003321 dimer interface [polypeptide binding]; other site 883062003322 motif 1; other site 883062003323 active site 883062003324 motif 2; other site 883062003325 motif 3; other site 883062003326 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 883062003327 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062003328 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619 883062003329 Walker A/P-loop; other site 883062003330 ATP binding site [chemical binding]; other site 883062003331 Q-loop/lid; other site 883062003332 ABC transporter signature motif; other site 883062003333 Walker B; other site 883062003334 D-loop; other site 883062003335 H-loop/switch region; other site 883062003336 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 883062003337 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 883062003338 Cupin domain; Region: Cupin_2; pfam07883 883062003339 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 883062003340 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 883062003341 catalytic core [active] 883062003342 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 883062003343 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 883062003344 catalytic site [active] 883062003345 Predicted membrane protein [Function unknown]; Region: COG2855 883062003346 Transcriptional regulator [Transcription]; Region: LysR; COG0583 883062003347 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 883062003348 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 883062003349 dimerization interface [polypeptide binding]; other site 883062003350 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 883062003351 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 883062003352 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 883062003353 active site 883062003354 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 883062003355 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 883062003356 Double zinc ribbon; Region: DZR; pfam12773 883062003357 PASTA domain; Region: PASTA; smart00740 883062003358 Predicted esterase [General function prediction only]; Region: COG0400 883062003359 putative hydrolase; Provisional; Region: PRK11460 883062003360 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 883062003361 active site 883062003362 catalytic residues [active] 883062003363 metal binding site [ion binding]; metal-binding site 883062003364 Nucleic-acid-binding protein containing Zn-ribbon domain (DUF2082); Region: DUF2082; pfam09855 883062003365 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 883062003366 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 883062003367 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062003368 non-specific DNA binding site [nucleotide binding]; other site 883062003369 salt bridge; other site 883062003370 sequence-specific DNA binding site [nucleotide binding]; other site 883062003371 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 883062003372 Short C-terminal domain; Region: SHOCT; pfam09851 883062003373 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062003374 non-specific DNA binding site [nucleotide binding]; other site 883062003375 salt bridge; other site 883062003376 sequence-specific DNA binding site [nucleotide binding]; other site 883062003377 Protein kinase domain; Region: Pkinase; pfam00069 883062003378 Catalytic domain of Protein Kinases; Region: PKc; cd00180 883062003379 active site 883062003380 ATP binding site [chemical binding]; other site 883062003381 substrate binding site [chemical binding]; other site 883062003382 activation loop (A-loop); other site 883062003383 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 883062003384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 883062003385 S-adenosylmethionine binding site [chemical binding]; other site 883062003386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 883062003387 hypothetical protein; Provisional; Region: PRK11770 883062003388 Domain of unknown function (DUF307); Region: DUF307; pfam03733 883062003389 Domain of unknown function (DUF307); Region: DUF307; pfam03733 883062003390 Transposase; Region: HTH_Tnp_1; pfam01527 883062003391 Integrase core domain; Region: rve; pfam00665 883062003392 Integrase core domain; Region: rve_3; pfam13683 883062003393 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 883062003394 non-specific DNA binding site [nucleotide binding]; other site 883062003395 salt bridge; other site 883062003396 sequence-specific DNA binding site [nucleotide binding]; other site 883062003397 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 883062003398 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 883062003399 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062003400 active site 883062003401 DNA protecting protein DprA; Region: dprA; TIGR00732 883062003402 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 883062003403 Domain of unknown function (DUF955); Region: DUF955; cl01076 883062003404 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 883062003405 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062003406 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062003407 active site 883062003408 DNA binding site [nucleotide binding] 883062003409 Int/Topo IB signature motif; other site 883062003410 GTP-binding protein YchF; Reviewed; Region: PRK09601 883062003411 YchF GTPase; Region: YchF; cd01900 883062003412 G1 box; other site 883062003413 GTP/Mg2+ binding site [chemical binding]; other site 883062003414 Switch I region; other site 883062003415 G2 box; other site 883062003416 Switch II region; other site 883062003417 G3 box; other site 883062003418 G4 box; other site 883062003419 G5 box; other site 883062003420 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 883062003421 transaminase; Reviewed; Region: PRK08068 883062003422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062003423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062003424 homodimer interface [polypeptide binding]; other site 883062003425 catalytic residue [active] 883062003426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062003427 dimer interface [polypeptide binding]; other site 883062003428 conserved gate region; other site 883062003429 ABC-ATPase subunit interface; other site 883062003430 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 883062003431 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 883062003432 Walker A/P-loop; other site 883062003433 ATP binding site [chemical binding]; other site 883062003434 Q-loop/lid; other site 883062003435 ABC transporter signature motif; other site 883062003436 Walker B; other site 883062003437 D-loop; other site 883062003438 H-loop/switch region; other site 883062003439 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 883062003440 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 883062003441 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 883062003442 alpha subunit interface [polypeptide binding]; other site 883062003443 TPP binding site [chemical binding]; other site 883062003444 heterodimer interface [polypeptide binding]; other site 883062003445 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 883062003446 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 883062003447 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 883062003448 tetramer interface [polypeptide binding]; other site 883062003449 TPP-binding site [chemical binding]; other site 883062003450 heterodimer interface [polypeptide binding]; other site 883062003451 phosphorylation loop region [posttranslational modification] 883062003452 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 883062003453 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 883062003454 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 883062003455 catalytic nucleophile [active] 883062003456 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 883062003457 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 883062003458 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 883062003459 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 883062003460 Histidine kinase; Region: HisKA_3; pfam07730 883062003461 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062003462 ATP binding site [chemical binding]; other site 883062003463 Mg2+ binding site [ion binding]; other site 883062003464 G-X-G motif; other site 883062003465 Histidine kinase; Region: HisKA_3; pfam07730 883062003466 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 883062003467 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062003468 active site 883062003469 phosphorylation site [posttranslational modification] 883062003470 intermolecular recognition site; other site 883062003471 dimerization interface [polypeptide binding]; other site 883062003472 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 883062003473 dimerization interface [polypeptide binding]; other site 883062003474 DNA binding residues [nucleotide binding] 883062003475 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 883062003476 active site 883062003477 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 883062003478 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 883062003479 active site 883062003480 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 883062003481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 883062003482 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 883062003483 FtsX-like permease family; Region: FtsX; pfam02687 883062003484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 883062003485 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 883062003486 Walker A/P-loop; other site 883062003487 ATP binding site [chemical binding]; other site 883062003488 Q-loop/lid; other site 883062003489 ABC transporter signature motif; other site 883062003490 Walker B; other site 883062003491 D-loop; other site 883062003492 H-loop/switch region; other site 883062003493 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 883062003494 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 883062003495 homodimer interface [polypeptide binding]; other site 883062003496 substrate-cofactor binding pocket; other site 883062003497 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062003498 catalytic residue [active] 883062003499 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 883062003500 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 883062003501 dimer interface [polypeptide binding]; other site 883062003502 pyridoxal binding site [chemical binding]; other site 883062003503 ATP binding site [chemical binding]; other site 883062003504 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 883062003505 L-aspartate oxidase; Provisional; Region: PRK06175 883062003506 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 883062003507 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 883062003508 DNA protecting protein DprA; Region: dprA; TIGR00732 883062003509 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 883062003510 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 883062003511 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062003512 Walker A motif; other site 883062003513 ATP binding site [chemical binding]; other site 883062003514 Walker B motif; other site 883062003515 arginine finger; other site 883062003516 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 883062003517 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 883062003518 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 883062003519 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 883062003520 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 883062003521 Methyltransferase domain; Region: Methyltransf_18; pfam12847 883062003522 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 883062003523 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 883062003524 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 883062003525 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 883062003526 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062003527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062003528 homodimer interface [polypeptide binding]; other site 883062003529 catalytic residue [active] 883062003530 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 883062003531 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 883062003532 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062003533 Walker A motif; other site 883062003534 ATP binding site [chemical binding]; other site 883062003535 Walker B motif; other site 883062003536 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 883062003537 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 883062003538 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 883062003539 oligomer interface [polypeptide binding]; other site 883062003540 active site residues [active] 883062003541 Clp protease; Region: CLP_protease; pfam00574 883062003542 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 883062003543 oligomer interface [polypeptide binding]; other site 883062003544 active site residues [active] 883062003545 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 883062003546 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 883062003547 putative ion selectivity filter; other site 883062003548 putative pore gating glutamate residue; other site 883062003549 trigger factor; Provisional; Region: tig; PRK01490 883062003550 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 883062003551 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 883062003552 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 883062003553 active site 883062003554 substrate binding site [chemical binding]; other site 883062003555 catalytic site [active] 883062003556 HRDC domain; Region: HRDC; pfam00570 883062003557 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 883062003558 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 883062003559 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 883062003560 FeS/SAM binding site; other site 883062003561 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 883062003562 Pyruvate formate lyase 1; Region: PFL1; cd01678 883062003563 coenzyme A binding site [chemical binding]; other site 883062003564 active site 883062003565 catalytic residues [active] 883062003566 glycine loop; other site 883062003567 NAD synthetase; Provisional; Region: PRK13981 883062003568 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 883062003569 multimer interface [polypeptide binding]; other site 883062003570 active site 883062003571 catalytic triad [active] 883062003572 protein interface 1 [polypeptide binding]; other site 883062003573 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 883062003574 homodimer interface [polypeptide binding]; other site 883062003575 NAD binding pocket [chemical binding]; other site 883062003576 ATP binding pocket [chemical binding]; other site 883062003577 Mg binding site [ion binding]; other site 883062003578 active-site loop [active] 883062003579 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 883062003580 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 883062003581 metal binding site [ion binding]; metal-binding site 883062003582 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 883062003583 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062003584 active site 883062003585 motif I; other site 883062003586 motif II; other site 883062003587 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 883062003588 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 883062003589 active site 883062003590 RelB antitoxin; Region: RelB; cl01171 883062003591 PemK-like protein; Region: PemK; pfam02452 883062003592 HipA-like C-terminal domain; Region: HipA_C; pfam07804 883062003593 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 883062003594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 883062003595 S-adenosylmethionine binding site [chemical binding]; other site 883062003596 EcsC protein family; Region: EcsC; pfam12787 883062003597 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 883062003598 FIC domain binding interface [polypeptide binding]; other site 883062003599 Fic/DOC family; Region: Fic; cl00960 883062003600 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 883062003601 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 883062003602 Int/Topo IB signature motif; other site 883062003603 DNA binding site [nucleotide binding] 883062003604 active site 883062003605 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 883062003606 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 883062003607 Zn2+ binding site [ion binding]; other site 883062003608 Mg2+ binding site [ion binding]; other site 883062003609 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 883062003610 synthetase active site [active] 883062003611 NTP binding site [chemical binding]; other site 883062003612 metal binding site [ion binding]; metal-binding site 883062003613 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 883062003614 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 883062003615 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 883062003616 trimer interface [polypeptide binding]; other site 883062003617 active site 883062003618 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 883062003619 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 883062003620 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 883062003621 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 883062003622 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 883062003623 CAP-like domain; other site 883062003624 active site 883062003625 primary dimer interface [polypeptide binding]; other site 883062003626 DEAD-like helicases superfamily; Region: DEXDc; smart00487 883062003627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062003628 ATP binding site [chemical binding]; other site 883062003629 putative Mg++ binding site [ion binding]; other site 883062003630 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 883062003631 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062003632 nucleotide binding region [chemical binding]; other site 883062003633 ATP-binding site [chemical binding]; other site 883062003634 DEAD/H associated; Region: DEAD_assoc; pfam08494 883062003635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062003636 salt bridge; other site 883062003637 non-specific DNA binding site [nucleotide binding]; other site 883062003638 sequence-specific DNA binding site [nucleotide binding]; other site 883062003639 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 883062003640 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 883062003641 Aspartase; Region: Aspartase; cd01357 883062003642 active sites [active] 883062003643 tetramer interface [polypeptide binding]; other site 883062003644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062003645 ATP binding site [chemical binding]; other site 883062003646 Mg2+ binding site [ion binding]; other site 883062003647 G-X-G motif; other site 883062003648 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 883062003649 anchoring element; other site 883062003650 dimer interface [polypeptide binding]; other site 883062003651 ATP binding site [chemical binding]; other site 883062003652 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 883062003653 active site 883062003654 metal binding site [ion binding]; metal-binding site 883062003655 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 883062003656 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 883062003657 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 883062003658 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 883062003659 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 883062003660 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 883062003661 DNA binding residues [nucleotide binding] 883062003662 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 883062003663 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 883062003664 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 883062003665 substrate binding pocket [chemical binding]; other site 883062003666 chain length determination region; other site 883062003667 substrate-Mg2+ binding site; other site 883062003668 catalytic residues [active] 883062003669 aspartate-rich region 1; other site 883062003670 active site lid residues [active] 883062003671 aspartate-rich region 2; other site 883062003672 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 883062003673 Catalytic domain of Protein Kinases; Region: PKc; cd00180 883062003674 active site 883062003675 ATP binding site [chemical binding]; other site 883062003676 substrate binding site [chemical binding]; other site 883062003677 activation loop (A-loop); other site 883062003678 PASTA domain; Region: PASTA; pfam03793 883062003679 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 883062003680 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 883062003681 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 883062003682 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 883062003683 putative acyl-acceptor binding pocket; other site 883062003684 Protein of unknown function (DUF4064); Region: DUF4064; pfam13273 883062003685 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 883062003686 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 883062003687 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 883062003688 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 883062003689 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062003690 ATP binding site [chemical binding]; other site 883062003691 putative Mg++ binding site [ion binding]; other site 883062003692 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 883062003693 SEC-C motif; Region: SEC-C; pfam02810 883062003694 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 883062003695 30S subunit binding site; other site 883062003696 recombination regulator RecX; Reviewed; Region: recX; PRK00117 883062003697 recombinase A; Provisional; Region: recA; PRK09354 883062003698 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 883062003699 hexamer interface [polypeptide binding]; other site 883062003700 Walker A motif; other site 883062003701 ATP binding site [chemical binding]; other site 883062003702 Walker B motif; other site 883062003703 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 883062003704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062003705 non-specific DNA binding site [nucleotide binding]; other site 883062003706 salt bridge; other site 883062003707 sequence-specific DNA binding site [nucleotide binding]; other site 883062003708 Competence-damaged protein; Region: CinA; pfam02464 883062003709 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 883062003710 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 883062003711 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 883062003712 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 883062003713 Fic/DOC family; Region: Fic; cl00960 883062003714 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 883062003715 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 883062003716 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 883062003717 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 883062003718 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 883062003719 FeS/SAM binding site; other site 883062003720 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 883062003721 synthetase active site [active] 883062003722 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 883062003723 NTP binding site [chemical binding]; other site 883062003724 metal binding site [ion binding]; metal-binding site 883062003725 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 883062003726 EamA-like transporter family; Region: EamA; pfam00892 883062003727 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 883062003728 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 883062003729 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 883062003730 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 883062003731 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062003732 active site 883062003733 phosphorylation site [posttranslational modification] 883062003734 intermolecular recognition site; other site 883062003735 dimerization interface [polypeptide binding]; other site 883062003736 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 883062003737 DNA binding residues [nucleotide binding] 883062003738 dimerization interface [polypeptide binding]; other site 883062003739 Protein of unknown function DUF262; Region: DUF262; pfam03235 883062003740 Uncharacterized conserved protein [Function unknown]; Region: COG1479 883062003741 Protein of unknown function DUF262; Region: DUF262; pfam03235 883062003742 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 883062003743 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 883062003744 active site 883062003745 dimer interface [polypeptide binding]; other site 883062003746 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 883062003747 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 883062003748 catalytic site [active] 883062003749 G-X2-G-X-G-K; other site 883062003750 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 883062003751 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 883062003752 ATP-grasp domain; Region: ATP-grasp_4; cl17255 883062003753 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 883062003754 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 883062003755 ATP-grasp domain; Region: ATP-grasp_4; cl17255 883062003756 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 883062003757 IMP binding site; other site 883062003758 dimer interface [polypeptide binding]; other site 883062003759 interdomain contacts; other site 883062003760 partial ornithine binding site; other site 883062003761 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 883062003762 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 883062003763 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 883062003764 catalytic site [active] 883062003765 subunit interface [polypeptide binding]; other site 883062003766 transcription antitermination factor NusB; Region: nusB; TIGR01951 883062003767 putative RNA binding site [nucleotide binding]; other site 883062003768 elongation factor P; Validated; Region: PRK00529 883062003769 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 883062003770 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 883062003771 RNA binding site [nucleotide binding]; other site 883062003772 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 883062003773 RNA binding site [nucleotide binding]; other site 883062003774 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062003775 H+ Antiporter protein; Region: 2A0121; TIGR00900 883062003776 putative substrate translocation pore; other site 883062003777 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 883062003778 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 883062003779 elongation factor Tu; Reviewed; Region: PRK00049 883062003780 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 883062003781 G1 box; other site 883062003782 GEF interaction site [polypeptide binding]; other site 883062003783 GTP/Mg2+ binding site [chemical binding]; other site 883062003784 Switch I region; other site 883062003785 G2 box; other site 883062003786 G3 box; other site 883062003787 Switch II region; other site 883062003788 G4 box; other site 883062003789 G5 box; other site 883062003790 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 883062003791 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 883062003792 Antibiotic Binding Site [chemical binding]; other site 883062003793 elongation factor G; Reviewed; Region: PRK00007 883062003794 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 883062003795 G1 box; other site 883062003796 putative GEF interaction site [polypeptide binding]; other site 883062003797 GTP/Mg2+ binding site [chemical binding]; other site 883062003798 Switch I region; other site 883062003799 G2 box; other site 883062003800 G3 box; other site 883062003801 Switch II region; other site 883062003802 G4 box; other site 883062003803 G5 box; other site 883062003804 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 883062003805 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 883062003806 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 883062003807 30S ribosomal protein S7; Validated; Region: PRK05302 883062003808 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 883062003809 S17 interaction site [polypeptide binding]; other site 883062003810 S8 interaction site; other site 883062003811 16S rRNA interaction site [nucleotide binding]; other site 883062003812 streptomycin interaction site [chemical binding]; other site 883062003813 23S rRNA interaction site [nucleotide binding]; other site 883062003814 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 883062003815 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 883062003816 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 883062003817 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 883062003818 catalytic residue [active] 883062003819 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 883062003820 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 883062003821 Right handed beta helix region; Region: Beta_helix; pfam13229 883062003822 Disaggregatase related; Region: Disaggr_assoc; pfam08480 883062003823 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 883062003824 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 883062003825 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 883062003826 ATP-grasp domain; Region: ATP-grasp; pfam02222 883062003827 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 883062003828 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 883062003829 ATP binding site [chemical binding]; other site 883062003830 active site 883062003831 substrate binding site [chemical binding]; other site 883062003832 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 883062003833 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 883062003834 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 883062003835 dimerization interface [polypeptide binding]; other site 883062003836 ATP binding site [chemical binding]; other site 883062003837 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 883062003838 dimerization interface [polypeptide binding]; other site 883062003839 ATP binding site [chemical binding]; other site 883062003840 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 883062003841 putative active site [active] 883062003842 catalytic triad [active] 883062003843 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 883062003844 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 883062003845 putative active site [active] 883062003846 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 883062003847 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 883062003848 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 883062003849 DNA polymerase IV; Reviewed; Region: PRK03103 883062003850 Y-family of DNA polymerases; Region: PolY; cl12025 883062003851 active site 883062003852 DNA binding site [nucleotide binding] 883062003853 amidophosphoribosyltransferase; Provisional; Region: PRK07272 883062003854 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 883062003855 active site 883062003856 tetramer interface [polypeptide binding]; other site 883062003857 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062003858 active site 883062003859 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 883062003860 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 883062003861 dimerization interface [polypeptide binding]; other site 883062003862 putative ATP binding site [chemical binding]; other site 883062003863 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 883062003864 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 883062003865 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 883062003866 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 883062003867 Sulfatase; Region: Sulfatase; pfam00884 883062003868 Putative esterase; Region: Esterase; pfam00756 883062003869 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 883062003870 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 883062003871 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 883062003872 metal binding site [ion binding]; metal-binding site 883062003873 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 883062003874 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 883062003875 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 883062003876 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 883062003877 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 883062003878 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 883062003879 Predicted permeases [General function prediction only]; Region: COG0701 883062003880 TIGR03943 family protein; Region: TIGR03943 883062003881 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 883062003882 metal binding site 2 [ion binding]; metal-binding site 883062003883 putative DNA binding helix; other site 883062003884 metal binding site 1 [ion binding]; metal-binding site 883062003885 dimer interface [polypeptide binding]; other site 883062003886 structural Zn2+ binding site [ion binding]; other site 883062003887 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 883062003888 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 883062003889 NAD binding site [chemical binding]; other site 883062003890 ATP-grasp domain; Region: ATP-grasp; pfam02222 883062003891 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 883062003892 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 883062003893 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 883062003894 NAD(P) binding site [chemical binding]; other site 883062003895 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 883062003896 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 883062003897 TPP-binding site; other site 883062003898 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 883062003899 PYR/PP interface [polypeptide binding]; other site 883062003900 dimer interface [polypeptide binding]; other site 883062003901 TPP binding site [chemical binding]; other site 883062003902 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 883062003903 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 883062003904 metal binding site [ion binding]; metal-binding site 883062003905 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 883062003906 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 883062003907 Activation domain of S53 peptidases; Region: Pro-peptidase_S53; cl07889 883062003908 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 883062003909 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 883062003910 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 883062003911 putative active site [active] 883062003912 DNA primase, catalytic core; Region: dnaG; TIGR01391 883062003913 CHC2 zinc finger; Region: zf-CHC2; cl17510 883062003914 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 883062003915 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 883062003916 active site 883062003917 metal binding site [ion binding]; metal-binding site 883062003918 interdomain interaction site; other site 883062003919 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 883062003920 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 883062003921 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 883062003922 Zn2+ binding site [ion binding]; other site 883062003923 Mg2+ binding site [ion binding]; other site 883062003924 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 883062003925 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 883062003926 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 883062003927 active site 883062003928 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 883062003929 dimer interface [polypeptide binding]; other site 883062003930 substrate binding site [chemical binding]; other site 883062003931 catalytic residues [active] 883062003932 amino acid transporter; Region: 2A0306; TIGR00909 883062003933 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 883062003934 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 883062003935 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 883062003936 S-ribosylhomocysteinase; Provisional; Region: PRK02260 883062003937 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 883062003938 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 883062003939 ATP binding site [chemical binding]; other site 883062003940 putative Mg++ binding site [ion binding]; other site 883062003941 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062003942 nucleotide binding region [chemical binding]; other site 883062003943 ATP-binding site [chemical binding]; other site 883062003944 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 883062003945 HRDC domain; Region: HRDC; pfam00570 883062003946 cystathionine gamma-synthase; Provisional; Region: PRK07811 883062003947 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 883062003948 homodimer interface [polypeptide binding]; other site 883062003949 substrate-cofactor binding pocket; other site 883062003950 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062003951 catalytic residue [active] 883062003952 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 883062003953 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 883062003954 dimer interface [polypeptide binding]; other site 883062003955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062003956 catalytic residue [active] 883062003957 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 883062003958 dimerization interface [polypeptide binding]; other site 883062003959 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 883062003960 NAD binding site [chemical binding]; other site 883062003961 ligand binding site [chemical binding]; other site 883062003962 catalytic site [active] 883062003963 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 883062003964 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 883062003965 Walker A/P-loop; other site 883062003966 ATP binding site [chemical binding]; other site 883062003967 Q-loop/lid; other site 883062003968 ABC transporter signature motif; other site 883062003969 Walker B; other site 883062003970 D-loop; other site 883062003971 H-loop/switch region; other site 883062003972 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 883062003973 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 883062003974 Walker A/P-loop; other site 883062003975 ATP binding site [chemical binding]; other site 883062003976 Q-loop/lid; other site 883062003977 ABC transporter signature motif; other site 883062003978 Walker B; other site 883062003979 D-loop; other site 883062003980 H-loop/switch region; other site 883062003981 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 883062003982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062003983 dimer interface [polypeptide binding]; other site 883062003984 conserved gate region; other site 883062003985 putative PBP binding loops; other site 883062003986 ABC-ATPase subunit interface; other site 883062003987 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 883062003988 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062003989 dimer interface [polypeptide binding]; other site 883062003990 conserved gate region; other site 883062003991 putative PBP binding loops; other site 883062003992 ABC-ATPase subunit interface; other site 883062003993 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 883062003994 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 883062003995 pantothenate kinase; Reviewed; Region: PRK13318 883062003996 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 883062003997 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 883062003998 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 883062003999 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 883062004000 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 883062004001 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 883062004002 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 883062004003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 883062004004 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 883062004005 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 883062004006 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 883062004007 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062004008 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062004009 DNA binding site [nucleotide binding] 883062004010 domain linker motif; other site 883062004011 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 883062004012 ligand binding site [chemical binding]; other site 883062004013 dimerization interface (open form) [polypeptide binding]; other site 883062004014 dimerization interface (closed form) [polypeptide binding]; other site 883062004015 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 883062004016 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 883062004017 NAD binding site [chemical binding]; other site 883062004018 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 883062004019 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 883062004020 Coagulation factor 5/8 C-terminal domain, discoidin domain; Region: FA58C; smart00231 883062004021 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062004022 sugar binding site [chemical binding]; other site 883062004023 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 883062004024 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 883062004025 HIGH motif; other site 883062004026 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 883062004027 active site 883062004028 KMSKS motif; other site 883062004029 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 883062004030 tRNA binding surface [nucleotide binding]; other site 883062004031 anticodon binding site; other site 883062004032 Membrane protein of unknown function; Region: DUF360; pfam04020 883062004033 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 883062004034 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 883062004035 NAD(P) binding site [chemical binding]; other site 883062004036 catalytic residues [active] 883062004037 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 883062004038 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 883062004039 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 883062004040 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 883062004041 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 883062004042 catalytic residue [active] 883062004043 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 883062004044 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 883062004045 homodimer interface [polypeptide binding]; other site 883062004046 substrate-cofactor binding pocket; other site 883062004047 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062004048 catalytic residue [active] 883062004049 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 883062004050 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 883062004051 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 883062004052 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 883062004053 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 883062004054 Walker A/P-loop; other site 883062004055 ATP binding site [chemical binding]; other site 883062004056 Q-loop/lid; other site 883062004057 ABC transporter signature motif; other site 883062004058 Walker B; other site 883062004059 D-loop; other site 883062004060 H-loop/switch region; other site 883062004061 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 883062004062 FtsX-like permease family; Region: FtsX; pfam02687 883062004063 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 883062004064 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 883062004065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062004066 motif II; other site 883062004067 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 883062004068 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 883062004069 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 883062004070 active site 883062004071 catalytic tetrad [active] 883062004072 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 883062004073 active site 883062004074 catalytic site [active] 883062004075 substrate binding site [chemical binding]; other site 883062004076 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 883062004077 Citrate synthase; Region: Citrate_synt; pfam00285 883062004078 oxalacetate binding site [chemical binding]; other site 883062004079 citrylCoA binding site [chemical binding]; other site 883062004080 coenzyme A binding site [chemical binding]; other site 883062004081 catalytic triad [active] 883062004082 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 883062004083 active site 883062004084 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 883062004085 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 883062004086 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 883062004087 active site 883062004088 Zn binding site [ion binding]; other site 883062004089 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 883062004090 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 883062004091 dimer interface [polypeptide binding]; other site 883062004092 ssDNA binding site [nucleotide binding]; other site 883062004093 tetramer (dimer of dimers) interface [polypeptide binding]; other site 883062004094 prolyl-tRNA synthetase; Provisional; Region: PRK09194 883062004095 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 883062004096 dimer interface [polypeptide binding]; other site 883062004097 motif 1; other site 883062004098 active site 883062004099 motif 2; other site 883062004100 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 883062004101 putative deacylase active site [active] 883062004102 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 883062004103 active site 883062004104 motif 3; other site 883062004105 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 883062004106 anticodon binding site; other site 883062004107 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062004108 PIF1-like helicase; Region: PIF1; pfam05970 883062004109 Walker A motif; other site 883062004110 ATP binding site [chemical binding]; other site 883062004111 Walker B motif; other site 883062004112 arginine finger; other site 883062004113 Helicase; Region: Herpes_Helicase; pfam02689 883062004114 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062004115 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 883062004116 active site 883062004117 motif I; other site 883062004118 motif II; other site 883062004119 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 883062004120 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 883062004121 catalytic site [active] 883062004122 putative active site [active] 883062004123 putative substrate binding site [chemical binding]; other site 883062004124 dimer interface [polypeptide binding]; other site 883062004125 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 883062004126 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062004127 ATP binding site [chemical binding]; other site 883062004128 G-X-G motif; other site 883062004129 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 883062004130 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 883062004131 active site 883062004132 catalytic site [active] 883062004133 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 883062004134 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 883062004135 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 883062004136 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 883062004137 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 883062004138 active site 883062004139 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 883062004140 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 883062004141 Mg++ binding site [ion binding]; other site 883062004142 putative catalytic motif [active] 883062004143 substrate binding site [chemical binding]; other site 883062004144 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 883062004145 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 883062004146 putative CoA binding site [chemical binding]; other site 883062004147 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 883062004148 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 883062004149 S-adenosylmethionine binding site [chemical binding]; other site 883062004150 peptide chain release factor 1; Validated; Region: prfA; PRK00591 883062004151 This domain is found in peptide chain release factors; Region: PCRF; smart00937 883062004152 RF-1 domain; Region: RF-1; pfam00472 883062004153 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 883062004154 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 883062004155 conserved cys residue [active] 883062004156 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 883062004157 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 883062004158 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 883062004159 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 883062004160 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 883062004161 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 883062004162 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 883062004163 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 883062004164 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 883062004165 S-adenosylmethionine binding site [chemical binding]; other site 883062004166 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 883062004167 active site 883062004168 phosphate binding residues; other site 883062004169 catalytic residues [active] 883062004170 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 883062004171 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 883062004172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 883062004173 ATP binding site [chemical binding]; other site 883062004174 putative Mg++ binding site [ion binding]; other site 883062004175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 883062004176 nucleotide binding region [chemical binding]; other site 883062004177 ATP-binding site [chemical binding]; other site 883062004178 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 883062004179 EamA-like transporter family; Region: EamA; pfam00892 883062004180 EamA-like transporter family; Region: EamA; pfam00892 883062004181 FtsX-like permease family; Region: FtsX; pfam02687 883062004182 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 883062004183 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 883062004184 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 883062004185 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 883062004186 homodimer interface [polypeptide binding]; other site 883062004187 substrate-cofactor binding pocket; other site 883062004188 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062004189 catalytic residue [active] 883062004190 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 883062004191 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 883062004192 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 883062004193 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 883062004194 nucleotide binding site [chemical binding]; other site 883062004195 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 883062004196 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062004197 Walker A/P-loop; other site 883062004198 ATP binding site [chemical binding]; other site 883062004199 Q-loop/lid; other site 883062004200 ABC transporter signature motif; other site 883062004201 Walker B; other site 883062004202 D-loop; other site 883062004203 H-loop/switch region; other site 883062004204 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 883062004205 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062004206 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 883062004207 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 883062004208 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 883062004209 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 883062004210 putative active site [active] 883062004211 Predicted membrane protein [Function unknown]; Region: COG3817 883062004212 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 883062004213 putative substrate binding pocket [chemical binding]; other site 883062004214 AC domain interface; other site 883062004215 catalytic triad [active] 883062004216 AB domain interface; other site 883062004217 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 883062004218 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 883062004219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062004220 Walker A/P-loop; other site 883062004221 ATP binding site [chemical binding]; other site 883062004222 Q-loop/lid; other site 883062004223 ABC transporter signature motif; other site 883062004224 Walker B; other site 883062004225 D-loop; other site 883062004226 H-loop/switch region; other site 883062004227 ABC transporter; Region: ABC_tran_2; pfam12848 883062004228 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 883062004229 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 883062004230 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 883062004231 active site 883062004232 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062004233 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 883062004234 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 883062004235 active site 883062004236 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 883062004237 catalytic triad [active] 883062004238 dimer interface [polypeptide binding]; other site 883062004239 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 883062004240 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 883062004241 homooctamer interface [polypeptide binding]; other site 883062004242 active site 883062004243 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 883062004244 catalytic center binding site [active] 883062004245 ATP binding site [chemical binding]; other site 883062004246 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 883062004247 catalytic center binding site [active] 883062004248 ATP binding site [chemical binding]; other site 883062004249 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 883062004250 dihydropteroate synthase; Region: DHPS; TIGR01496 883062004251 substrate binding pocket [chemical binding]; other site 883062004252 dimer interface [polypeptide binding]; other site 883062004253 inhibitor binding site; inhibition site 883062004254 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 883062004255 GTP cyclohydrolase I; Provisional; Region: PLN03044 883062004256 active site 883062004257 FtsH Extracellular; Region: FtsH_ext; pfam06480 883062004258 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 883062004259 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062004260 Walker A motif; other site 883062004261 ATP binding site [chemical binding]; other site 883062004262 Walker B motif; other site 883062004263 arginine finger; other site 883062004264 Peptidase family M41; Region: Peptidase_M41; pfam01434 883062004265 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 883062004266 active site 883062004267 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 883062004268 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 883062004269 Ligand Binding Site [chemical binding]; other site 883062004270 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 883062004271 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 883062004272 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 883062004273 Walker A/P-loop; other site 883062004274 ATP binding site [chemical binding]; other site 883062004275 Q-loop/lid; other site 883062004276 ABC transporter signature motif; other site 883062004277 Walker B; other site 883062004278 D-loop; other site 883062004279 H-loop/switch region; other site 883062004280 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 883062004281 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 883062004282 DXD motif; other site 883062004283 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 883062004284 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 883062004285 Domain of unknown function DUF20; Region: UPF0118; pfam01594 883062004286 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 883062004287 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 883062004288 active site 883062004289 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 883062004290 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 883062004291 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 883062004292 dimer interface [polypeptide binding]; other site 883062004293 active site 883062004294 metal binding site [ion binding]; metal-binding site 883062004295 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 883062004296 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 883062004297 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 883062004298 NAD(P) binding site [chemical binding]; other site 883062004299 active site 883062004300 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 883062004301 potential protein location (hypothetical protein BBIF_1402 [Bifidobacterium bifidum S17]) that overlaps RNA (tRNA-E) 883062004302 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 883062004303 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 883062004304 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 883062004305 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 883062004306 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 883062004307 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 883062004308 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 883062004309 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 883062004310 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062004311 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062004312 DNA binding site [nucleotide binding] 883062004313 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 883062004314 putative ligand binding site [chemical binding]; other site 883062004315 putative dimerization interface [polypeptide binding]; other site 883062004316 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 883062004317 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 883062004318 dimer interface [polypeptide binding]; other site 883062004319 phosphorylation site [posttranslational modification] 883062004320 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062004321 ATP binding site [chemical binding]; other site 883062004322 Mg2+ binding site [ion binding]; other site 883062004323 G-X-G motif; other site 883062004324 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 883062004325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062004326 active site 883062004327 phosphorylation site [posttranslational modification] 883062004328 intermolecular recognition site; other site 883062004329 dimerization interface [polypeptide binding]; other site 883062004330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 883062004331 DNA binding site [nucleotide binding] 883062004332 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 883062004333 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062004334 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 883062004335 Walker A/P-loop; other site 883062004336 ATP binding site [chemical binding]; other site 883062004337 Q-loop/lid; other site 883062004338 ABC transporter signature motif; other site 883062004339 Walker B; other site 883062004340 D-loop; other site 883062004341 H-loop/switch region; other site 883062004342 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 883062004343 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 883062004344 FtsX-like permease family; Region: FtsX; pfam02687 883062004345 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 883062004346 FtsX-like permease family; Region: FtsX; pfam02687 883062004347 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 883062004348 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 883062004349 Walker A/P-loop; other site 883062004350 ATP binding site [chemical binding]; other site 883062004351 Q-loop/lid; other site 883062004352 ABC transporter signature motif; other site 883062004353 Walker B; other site 883062004354 D-loop; other site 883062004355 H-loop/switch region; other site 883062004356 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 883062004357 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 883062004358 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 883062004359 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 883062004360 Low molecular weight phosphatase family; Region: LMWPc; cd00115 883062004361 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 883062004362 active site 883062004363 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 883062004364 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 883062004365 folate binding site [chemical binding]; other site 883062004366 NADP+ binding site [chemical binding]; other site 883062004367 thymidylate synthase; Reviewed; Region: thyA; PRK01827 883062004368 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 883062004369 dimerization interface [polypeptide binding]; other site 883062004370 active site 883062004371 OsmC-like protein; Region: OsmC; pfam02566 883062004372 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 883062004373 Ligand Binding Site [chemical binding]; other site 883062004374 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 883062004375 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 883062004376 NlpC/P60 family; Region: NLPC_P60; pfam00877 883062004377 Surface antigen [General function prediction only]; Region: COG3942 883062004378 CHAP domain; Region: CHAP; pfam05257 883062004379 phosphoserine aminotransferase; Provisional; Region: PRK03080 883062004380 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 883062004381 catalytic residue [active] 883062004382 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 883062004383 dimer interface [polypeptide binding]; other site 883062004384 phosphorylation site [posttranslational modification] 883062004385 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 883062004386 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062004387 ATP binding site [chemical binding]; other site 883062004388 Mg2+ binding site [ion binding]; other site 883062004389 G-X-G motif; other site 883062004390 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 883062004391 PhoU domain; Region: PhoU; pfam01895 883062004392 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 883062004393 catalytic core [active] 883062004394 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 883062004395 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 883062004396 UbiA prenyltransferase family; Region: UbiA; pfam01040 883062004397 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 883062004398 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 883062004399 dimer interface [polypeptide binding]; other site 883062004400 putative anticodon binding site; other site 883062004401 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 883062004402 motif 1; other site 883062004403 dimer interface [polypeptide binding]; other site 883062004404 active site 883062004405 motif 2; other site 883062004406 motif 3; other site 883062004407 MFS transport protein AraJ; Provisional; Region: PRK10091 883062004408 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062004409 putative substrate translocation pore; other site 883062004410 Tetratricopeptide repeat; Region: TPR_12; pfam13424 883062004411 Tetratricopeptide repeat; Region: TPR_12; pfam13424 883062004412 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 883062004413 binding surface 883062004414 TPR motif; other site 883062004415 Tetratricopeptide repeat; Region: TPR_12; pfam13424 883062004416 Tetratricopeptide repeat; Region: TPR_12; pfam13424 883062004417 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 883062004418 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 883062004419 ribonuclease E; Reviewed; Region: rne; PRK10811 883062004420 PspC domain; Region: PspC; pfam04024 883062004421 Tetraspanin family; Region: Tetraspannin; pfam00335 883062004422 PspC domain; Region: PspC; pfam04024 883062004423 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 883062004424 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 883062004425 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 883062004426 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062004427 active site 883062004428 phosphorylation site [posttranslational modification] 883062004429 intermolecular recognition site; other site 883062004430 dimerization interface [polypeptide binding]; other site 883062004431 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 883062004432 DNA binding residues [nucleotide binding] 883062004433 dimerization interface [polypeptide binding]; other site 883062004434 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 883062004435 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 883062004436 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 883062004437 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 883062004438 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 883062004439 putative active site [active] 883062004440 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 883062004441 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 883062004442 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 883062004443 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 883062004444 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 883062004445 Alpha-N-acetylglucosaminidase (NAGLU) N-terminal domain; Region: NAGLU_N; pfam12971 883062004446 Alpha-N-acetylglucosaminidase (NAGLU) tim-barrel domain; Region: NAGLU; pfam05089 883062004447 Alpha-N-acetylglucosaminidase (NAGLU) C-terminal domain; Region: NAGLU_C; pfam12972 883062004448 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062004449 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062004450 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062004451 seryl-tRNA synthetase; Provisional; Region: PRK05431 883062004452 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 883062004453 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 883062004454 dimer interface [polypeptide binding]; other site 883062004455 active site 883062004456 motif 1; other site 883062004457 motif 2; other site 883062004458 motif 3; other site 883062004459 Predicted extracellular nuclease [General function prediction only]; Region: COG2374 883062004460 YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486 883062004461 generic binding surface I; other site 883062004462 generic binding surface II; other site 883062004463 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 883062004464 putative active site [active] 883062004465 putative catalytic site [active] 883062004466 putative Mg binding site IVb [ion binding]; other site 883062004467 putative phosphate binding site [ion binding]; other site 883062004468 putative DNA binding site [nucleotide binding]; other site 883062004469 putative Mg binding site IVa [ion binding]; other site 883062004470 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 883062004471 Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412 883062004472 putative active site [active] 883062004473 putative metal binding site [ion binding]; other site 883062004474 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 883062004475 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 883062004476 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 883062004477 transcriptional antiterminator BglG; Provisional; Region: PRK09772 883062004478 CAT RNA binding domain; Region: CAT_RBD; smart01061 883062004479 PRD domain; Region: PRD; pfam00874 883062004480 PRD domain; Region: PRD; pfam00874 883062004481 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 883062004482 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 883062004483 active site turn [active] 883062004484 phosphorylation site [posttranslational modification] 883062004485 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 883062004486 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 883062004487 HPr interaction site; other site 883062004488 glycerol kinase (GK) interaction site [polypeptide binding]; other site 883062004489 active site 883062004490 phosphorylation site [posttranslational modification] 883062004491 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 883062004492 phosphoglucomutase; Validated; Region: PRK07564 883062004493 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 883062004494 active site 883062004495 substrate binding site [chemical binding]; other site 883062004496 metal binding site [ion binding]; metal-binding site 883062004497 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 883062004498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 883062004499 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 883062004500 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 883062004501 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062004502 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062004503 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 883062004504 RNA/DNA hybrid binding site [nucleotide binding]; other site 883062004505 active site 883062004506 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 883062004507 tetramer (dimer of dimers) interface [polypeptide binding]; other site 883062004508 active site 883062004509 dimer interface [polypeptide binding]; other site 883062004510 DNA repair protein RadA; Provisional; Region: PRK11823 883062004511 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 883062004512 Walker A motif; other site 883062004513 ATP binding site [chemical binding]; other site 883062004514 Walker B motif; other site 883062004515 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 883062004516 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 883062004517 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 883062004518 active site 883062004519 Riboflavin kinase; Region: Flavokinase; smart00904 883062004520 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 883062004521 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 883062004522 RNA binding site [nucleotide binding]; other site 883062004523 active site 883062004524 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 883062004525 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 883062004526 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 883062004527 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 883062004528 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 883062004529 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 883062004530 G1 box; other site 883062004531 putative GEF interaction site [polypeptide binding]; other site 883062004532 GTP/Mg2+ binding site [chemical binding]; other site 883062004533 Switch I region; other site 883062004534 G2 box; other site 883062004535 G3 box; other site 883062004536 Switch II region; other site 883062004537 G4 box; other site 883062004538 G5 box; other site 883062004539 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 883062004540 Translation-initiation factor 2; Region: IF-2; pfam11987 883062004541 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 883062004542 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 883062004543 NusA N-terminal domain; Region: NusA_N; pfam08529 883062004544 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 883062004545 RNA binding site [nucleotide binding]; other site 883062004546 homodimer interface [polypeptide binding]; other site 883062004547 NusA-like KH domain; Region: KH_5; pfam13184 883062004548 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 883062004549 G-X-X-G motif; other site 883062004550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 883062004551 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 883062004552 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 883062004553 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 883062004554 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 883062004555 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 883062004556 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 883062004557 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 883062004558 dimerization interface 3.5A [polypeptide binding]; other site 883062004559 active site 883062004560 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062004561 sugar binding site [chemical binding]; other site 883062004562 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 883062004563 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 883062004564 active site 883062004565 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 883062004566 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 883062004567 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 883062004568 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 883062004569 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 883062004570 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 883062004571 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 883062004572 alphaNTD homodimer interface [polypeptide binding]; other site 883062004573 alphaNTD - beta interaction site [polypeptide binding]; other site 883062004574 alphaNTD - beta' interaction site [polypeptide binding]; other site 883062004575 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 883062004576 30S ribosomal protein S11; Validated; Region: PRK05309 883062004577 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 883062004578 30S ribosomal protein S13; Region: bact_S13; TIGR03631 883062004579 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 883062004580 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 883062004581 rRNA binding site [nucleotide binding]; other site 883062004582 predicted 30S ribosome binding site; other site 883062004583 adenylate kinase; Reviewed; Region: adk; PRK00279 883062004584 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 883062004585 AMP-binding site [chemical binding]; other site 883062004586 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 883062004587 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 883062004588 SecY translocase; Region: SecY; pfam00344 883062004589 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 883062004590 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 883062004591 23S rRNA binding site [nucleotide binding]; other site 883062004592 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 883062004593 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 883062004594 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 883062004595 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 883062004596 5S rRNA interface [nucleotide binding]; other site 883062004597 23S rRNA interface [nucleotide binding]; other site 883062004598 L5 interface [polypeptide binding]; other site 883062004599 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 883062004600 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 883062004601 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 883062004602 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 883062004603 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 883062004604 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 883062004605 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 883062004606 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 883062004607 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 883062004608 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 883062004609 RNA binding site [nucleotide binding]; other site 883062004610 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 883062004611 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 883062004612 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 883062004613 23S rRNA interface [nucleotide binding]; other site 883062004614 putative translocon interaction site; other site 883062004615 signal recognition particle (SRP54) interaction site; other site 883062004616 L23 interface [polypeptide binding]; other site 883062004617 trigger factor interaction site; other site 883062004618 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 883062004619 23S rRNA interface [nucleotide binding]; other site 883062004620 5S rRNA interface [nucleotide binding]; other site 883062004621 putative antibiotic binding site [chemical binding]; other site 883062004622 L25 interface [polypeptide binding]; other site 883062004623 L27 interface [polypeptide binding]; other site 883062004624 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 883062004625 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 883062004626 G-X-X-G motif; other site 883062004627 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 883062004628 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 883062004629 putative translocon binding site; other site 883062004630 protein-rRNA interface [nucleotide binding]; other site 883062004631 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 883062004632 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 883062004633 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 883062004634 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 883062004635 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 883062004636 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 883062004637 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 883062004638 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 883062004639 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 883062004640 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 883062004641 YwiC-like protein; Region: YwiC; pfam14256 883062004642 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 883062004643 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 883062004644 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 883062004645 putative catalytic cysteine [active] 883062004646 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 883062004647 putative active site [active] 883062004648 metal binding site [ion binding]; metal-binding site 883062004649 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 883062004650 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 883062004651 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 883062004652 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 883062004653 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 883062004654 pullulanase, type I; Region: pulA_typeI; TIGR02104 883062004655 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 883062004656 active site 883062004657 catalytic site [active] 883062004658 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 883062004659 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 883062004660 23S rRNA interface [nucleotide binding]; other site 883062004661 L3 interface [polypeptide binding]; other site 883062004662 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 883062004663 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 883062004664 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 883062004665 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 883062004666 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 883062004667 putative active site [active] 883062004668 putative metal binding site [ion binding]; other site 883062004669 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 883062004670 active site 883062004671 DNA polymerase IV; Validated; Region: PRK02406 883062004672 DNA binding site [nucleotide binding] 883062004673 Protein of unknown function (DUF3812); Region: DUF3812; pfam12757 883062004674 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 883062004675 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062004676 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062004677 homodimer interface [polypeptide binding]; other site 883062004678 catalytic residue [active] 883062004679 Ferredoxin [Energy production and conversion]; Region: COG1146 883062004680 4Fe-4S binding domain; Region: Fer4; pfam00037 883062004681 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 883062004682 FAD binding domain; Region: FAD_binding_4; pfam01565 883062004683 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 883062004684 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 883062004685 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 883062004686 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 883062004687 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 883062004688 oligomerisation interface [polypeptide binding]; other site 883062004689 mobile loop; other site 883062004690 roof hairpin; other site 883062004691 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 883062004692 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 883062004693 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 883062004694 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 883062004695 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 883062004696 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 883062004697 Part of AAA domain; Region: AAA_19; pfam13245 883062004698 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 883062004699 phosphopeptide binding site; other site 883062004700 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 883062004701 peripheral dimer interface [polypeptide binding]; other site 883062004702 core dimer interface [polypeptide binding]; other site 883062004703 L10 interface [polypeptide binding]; other site 883062004704 L11 interface [polypeptide binding]; other site 883062004705 putative EF-Tu interaction site [polypeptide binding]; other site 883062004706 putative EF-G interaction site [polypeptide binding]; other site 883062004707 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 883062004708 23S rRNA interface [nucleotide binding]; other site 883062004709 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 883062004710 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 883062004711 active site 883062004712 catalytic triad [active] 883062004713 oxyanion hole [active] 883062004714 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 883062004715 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 883062004716 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 883062004717 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 883062004718 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 883062004719 Asp-box motif; other site 883062004720 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 883062004721 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 883062004722 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 883062004723 Walker A/P-loop; other site 883062004724 ATP binding site [chemical binding]; other site 883062004725 Q-loop/lid; other site 883062004726 ABC transporter signature motif; other site 883062004727 Walker B; other site 883062004728 D-loop; other site 883062004729 H-loop/switch region; other site 883062004730 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 883062004731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062004732 dimer interface [polypeptide binding]; other site 883062004733 conserved gate region; other site 883062004734 putative PBP binding loops; other site 883062004735 ABC-ATPase subunit interface; other site 883062004736 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 883062004737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 883062004738 dimer interface [polypeptide binding]; other site 883062004739 conserved gate region; other site 883062004740 putative PBP binding loops; other site 883062004741 ABC-ATPase subunit interface; other site 883062004742 PBP superfamily domain; Region: PBP_like_2; cl17296 883062004743 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 883062004744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 883062004745 active site 883062004746 phosphorylation site [posttranslational modification] 883062004747 intermolecular recognition site; other site 883062004748 dimerization interface [polypeptide binding]; other site 883062004749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 883062004750 DNA binding site [nucleotide binding] 883062004751 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 883062004752 dimer interface [polypeptide binding]; other site 883062004753 phosphorylation site [posttranslational modification] 883062004754 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 883062004755 ATP binding site [chemical binding]; other site 883062004756 Mg2+ binding site [ion binding]; other site 883062004757 G-X-G motif; other site 883062004758 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 883062004759 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 883062004760 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 883062004761 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 883062004762 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 883062004763 dimerization interface [polypeptide binding]; other site 883062004764 putative DNA binding site [nucleotide binding]; other site 883062004765 putative Zn2+ binding site [ion binding]; other site 883062004766 potential frameshift: common BLAST hit: gi|213691868|ref|YP_002322454.1| major facilitator superfamily MFS_1 883062004767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062004768 Major Facilitator Superfamily; Region: MFS_1; pfam07690 883062004769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062004770 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 883062004771 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 883062004772 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 883062004773 Excalibur calcium-binding domain; Region: Excalibur; pfam05901 883062004774 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 883062004775 trimer interface [polypeptide binding]; other site 883062004776 active site 883062004777 G bulge; other site 883062004778 chromosome segregation protein; Provisional; Region: PRK02224 883062004779 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 883062004780 putative substrate binding pocket [chemical binding]; other site 883062004781 AC domain interface; other site 883062004782 catalytic triad [active] 883062004783 AB domain interface; other site 883062004784 interchain disulfide; other site 883062004785 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 883062004786 substrate binding site; other site 883062004787 dimer interface; other site 883062004788 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 883062004789 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 883062004790 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 883062004791 Peptidase family U32; Region: Peptidase_U32; pfam01136 883062004792 potential frameshift: common BLAST hit: gi|296454255|ref|YP_003661398.1| IS3509a transposase 883062004793 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 883062004794 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 883062004795 active site 883062004796 catalytic tetrad [active] 883062004797 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 883062004798 catalytic residues [active] 883062004799 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 883062004800 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 883062004801 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 883062004802 Class I ribonucleotide reductase; Region: RNR_I; cd01679 883062004803 active site 883062004804 dimer interface [polypeptide binding]; other site 883062004805 catalytic residues [active] 883062004806 effector binding site; other site 883062004807 R2 peptide binding site; other site 883062004808 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 883062004809 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 883062004810 dimer interface [polypeptide binding]; other site 883062004811 putative radical transfer pathway; other site 883062004812 diiron center [ion binding]; other site 883062004813 tyrosyl radical; other site 883062004814 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 883062004815 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 883062004816 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 883062004817 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062004818 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062004819 DNA binding site [nucleotide binding] 883062004820 domain linker motif; other site 883062004821 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 883062004822 dimerization interface [polypeptide binding]; other site 883062004823 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 883062004824 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 883062004825 oligomer interface [polypeptide binding]; other site 883062004826 RNA binding site [nucleotide binding]; other site 883062004827 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 883062004828 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 883062004829 RNase E interface [polypeptide binding]; other site 883062004830 trimer interface [polypeptide binding]; other site 883062004831 active site 883062004832 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 883062004833 putative nucleic acid binding region [nucleotide binding]; other site 883062004834 G-X-X-G motif; other site 883062004835 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 883062004836 RNA binding site [nucleotide binding]; other site 883062004837 domain interface; other site 883062004838 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 883062004839 16S/18S rRNA binding site [nucleotide binding]; other site 883062004840 S13e-L30e interaction site [polypeptide binding]; other site 883062004841 25S rRNA binding site [nucleotide binding]; other site 883062004842 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 883062004843 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 883062004844 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 883062004845 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 883062004846 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 883062004847 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 883062004848 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 883062004849 phosphate binding site [ion binding]; other site 883062004850 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 883062004851 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 883062004852 putative active site [active] 883062004853 putative catalytic site [active] 883062004854 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 883062004855 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 883062004856 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 883062004857 putative NAD(P) binding site [chemical binding]; other site 883062004858 active site 883062004859 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 883062004860 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 883062004861 active site 883062004862 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 883062004863 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 883062004864 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 883062004865 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 883062004866 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 883062004867 ATP-grasp domain; Region: ATP-grasp_4; cl17255 883062004868 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 883062004869 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 883062004870 carboxyltransferase (CT) interaction site; other site 883062004871 biotinylation site [posttranslational modification]; other site 883062004872 BioY family; Region: BioY; pfam02632 883062004873 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 883062004874 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 883062004875 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 883062004876 Protein of unknown function (DUF935); Region: DUF935; pfam06074 883062004877 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 883062004878 hypothetical protein; Provisional; Region: PRK03298 883062004879 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 883062004880 gamma subunit interface [polypeptide binding]; other site 883062004881 epsilon subunit interface [polypeptide binding]; other site 883062004882 LBP interface [polypeptide binding]; other site 883062004883 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 883062004884 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 883062004885 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 883062004886 alpha subunit interaction interface [polypeptide binding]; other site 883062004887 Walker A motif; other site 883062004888 ATP binding site [chemical binding]; other site 883062004889 Walker B motif; other site 883062004890 inhibitor binding site; inhibition site 883062004891 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 883062004892 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 883062004893 core domain interface [polypeptide binding]; other site 883062004894 delta subunit interface [polypeptide binding]; other site 883062004895 epsilon subunit interface [polypeptide binding]; other site 883062004896 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 883062004897 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 883062004898 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 883062004899 beta subunit interaction interface [polypeptide binding]; other site 883062004900 Walker A motif; other site 883062004901 ATP binding site [chemical binding]; other site 883062004902 Walker B motif; other site 883062004903 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 883062004904 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 883062004905 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 883062004906 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 883062004907 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 883062004908 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 883062004909 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 883062004910 homoserine O-succinyltransferase; Provisional; Region: PRK05368 883062004911 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 883062004912 proposed active site lysine [active] 883062004913 conserved cys residue [active] 883062004914 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 883062004915 non-specific DNA binding site [nucleotide binding]; other site 883062004916 salt bridge; other site 883062004917 sequence-specific DNA binding site [nucleotide binding]; other site 883062004918 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 883062004919 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 883062004920 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 883062004921 active site 883062004922 homodimer interface [polypeptide binding]; other site 883062004923 catalytic site [active] 883062004924 acceptor binding site [chemical binding]; other site 883062004925 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 883062004926 dimer interface [polypeptide binding]; other site 883062004927 substrate binding site [chemical binding]; other site 883062004928 metal binding sites [ion binding]; metal-binding site 883062004929 Predicted membrane protein [Function unknown]; Region: COG1971 883062004930 Domain of unknown function DUF; Region: DUF204; pfam02659 883062004931 Domain of unknown function DUF; Region: DUF204; pfam02659 883062004932 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 883062004933 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 883062004934 DNA binding site [nucleotide binding] 883062004935 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 883062004936 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 883062004937 minor groove reading motif; other site 883062004938 helix-hairpin-helix signature motif; other site 883062004939 substrate binding pocket [chemical binding]; other site 883062004940 active site 883062004941 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 883062004942 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 883062004943 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 883062004944 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 883062004945 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 883062004946 active site 883062004947 HIGH motif; other site 883062004948 nucleotide binding site [chemical binding]; other site 883062004949 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 883062004950 active site 883062004951 KMSKS motif; other site 883062004952 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 883062004953 tRNA binding surface [nucleotide binding]; other site 883062004954 anticodon binding site; other site 883062004955 chorismate mutase; Provisional; Region: PRK09239 883062004956 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 883062004957 dimerization interface [polypeptide binding]; other site 883062004958 putative DNA binding site [nucleotide binding]; other site 883062004959 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 883062004960 putative Zn2+ binding site [ion binding]; other site 883062004961 AsnC family; Region: AsnC_trans_reg; pfam01037 883062004962 aspartate aminotransferase; Provisional; Region: PRK05764 883062004963 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 883062004964 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062004965 homodimer interface [polypeptide binding]; other site 883062004966 catalytic residue [active] 883062004967 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 883062004968 transcription termination factor Rho; Provisional; Region: PRK12608 883062004969 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 883062004970 RNA binding site [nucleotide binding]; other site 883062004971 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 883062004972 multimer interface [polypeptide binding]; other site 883062004973 Walker A motif; other site 883062004974 ATP binding site [chemical binding]; other site 883062004975 Walker B motif; other site 883062004976 hypothetical protein; Provisional; Region: PRK07208 883062004977 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 883062004978 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 883062004979 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 883062004980 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 883062004981 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 883062004982 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 883062004983 GatB domain; Region: GatB_Yqey; pfam02637 883062004984 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 883062004985 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 883062004986 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 883062004987 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062004988 Walker A/P-loop; other site 883062004989 ATP binding site [chemical binding]; other site 883062004990 Q-loop/lid; other site 883062004991 ABC transporter signature motif; other site 883062004992 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 883062004993 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 883062004994 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 883062004995 RmuC family; Region: RmuC; pfam02646 883062004996 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 883062004997 putative homodimer interface [polypeptide binding]; other site 883062004998 putative homotetramer interface [polypeptide binding]; other site 883062004999 putative allosteric switch controlling residues; other site 883062005000 putative metal binding site [ion binding]; other site 883062005001 putative homodimer-homodimer interface [polypeptide binding]; other site 883062005002 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 883062005003 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 883062005004 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 883062005005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062005006 active site 883062005007 motif I; other site 883062005008 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 883062005009 motif II; other site 883062005010 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 883062005011 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 883062005012 ABC1 family; Region: ABC1; cl17513 883062005013 Uncharacterized conserved protein [Function unknown]; Region: COG3937 883062005014 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 883062005015 catalytic triad [active] 883062005016 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 883062005017 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 883062005018 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 883062005019 replicative DNA helicase; Region: DnaB; TIGR00665 883062005020 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 883062005021 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 883062005022 Walker A motif; other site 883062005023 ATP binding site [chemical binding]; other site 883062005024 Walker B motif; other site 883062005025 DNA binding loops [nucleotide binding] 883062005026 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 883062005027 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 883062005028 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 883062005029 metal binding triad; other site 883062005030 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 883062005031 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 883062005032 Zn2+ binding site [ion binding]; other site 883062005033 Mg2+ binding site [ion binding]; other site 883062005034 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 883062005035 Nitrogen regulatory protein P-II; Region: P-II; smart00938 883062005036 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 883062005037 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 883062005038 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 883062005039 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 883062005040 potential frameshift: common BLAST hit: gi|119025128|ref|YP_908973.1| TetR-type transcriptional regulator 883062005041 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 883062005042 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 883062005043 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 883062005044 active site 883062005045 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 883062005046 Peptidase family C69; Region: Peptidase_C69; pfam03577 883062005047 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 883062005048 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 883062005049 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 883062005050 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 883062005051 Walker A/P-loop; other site 883062005052 ATP binding site [chemical binding]; other site 883062005053 Q-loop/lid; other site 883062005054 ABC transporter signature motif; other site 883062005055 Walker B; other site 883062005056 D-loop; other site 883062005057 H-loop/switch region; other site 883062005058 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 883062005059 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 883062005060 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062005061 Walker A/P-loop; other site 883062005062 ATP binding site [chemical binding]; other site 883062005063 Q-loop/lid; other site 883062005064 ABC transporter signature motif; other site 883062005065 Walker B; other site 883062005066 D-loop; other site 883062005067 H-loop/switch region; other site 883062005068 MarR family; Region: MarR_2; pfam12802 883062005069 Transcriptional regulators [Transcription]; Region: MarR; COG1846 883062005070 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 883062005071 Cna protein B-type domain; Region: Cna_B; pfam05738 883062005072 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 883062005073 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 883062005074 active site 883062005075 catalytic site [active] 883062005076 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062005077 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 883062005078 active site 883062005079 motif I; other site 883062005080 motif II; other site 883062005081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062005082 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 883062005083 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 883062005084 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 883062005085 active site 883062005086 motif I; other site 883062005087 motif II; other site 883062005088 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 883062005089 beta-galactosidase; Region: BGL; TIGR03356 883062005090 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 883062005091 methionine cluster; other site 883062005092 active site 883062005093 phosphorylation site [posttranslational modification] 883062005094 metal binding site [ion binding]; metal-binding site 883062005095 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 883062005096 active site 883062005097 P-loop; other site 883062005098 phosphorylation site [posttranslational modification] 883062005099 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 883062005100 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 883062005101 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 883062005102 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 883062005103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 883062005104 DNA-binding site [nucleotide binding]; DNA binding site 883062005105 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 883062005106 FMN-binding domain; Region: FMN_bind; pfam04205 883062005107 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 883062005108 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 883062005109 Walker A/P-loop; other site 883062005110 ATP binding site [chemical binding]; other site 883062005111 Q-loop/lid; other site 883062005112 ABC transporter signature motif; other site 883062005113 Walker B; other site 883062005114 D-loop; other site 883062005115 H-loop/switch region; other site 883062005116 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 883062005117 FtsX-like permease family; Region: FtsX; pfam02687 883062005118 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 883062005119 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 883062005120 FtsX-like permease family; Region: FtsX; pfam02687 883062005121 Predicted membrane protein [Function unknown]; Region: COG4393 883062005122 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 883062005123 Fe2+ transport protein; Region: Iron_transport; pfam10634 883062005124 Iron permease FTR1 family; Region: FTR1; cl00475 883062005125 ApbE family; Region: ApbE; pfam02424 883062005126 Fic family protein [Function unknown]; Region: COG3177 883062005127 Fic/DOC family; Region: Fic; pfam02661 883062005128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 883062005129 putative Zn2+ binding site [ion binding]; other site 883062005130 putative DNA binding site [nucleotide binding]; other site 883062005131 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 883062005132 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 883062005133 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 883062005134 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 883062005135 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 883062005136 dimerization domain swap beta strand [polypeptide binding]; other site 883062005137 regulatory protein interface [polypeptide binding]; other site 883062005138 active site 883062005139 regulatory phosphorylation site [posttranslational modification]; other site 883062005140 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062005141 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062005142 DNA binding site [nucleotide binding] 883062005143 domain linker motif; other site 883062005144 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 883062005145 dimerization interface [polypeptide binding]; other site 883062005146 ligand binding site [chemical binding]; other site 883062005147 DNA polymerase III subunit delta'; Validated; Region: PRK07940 883062005148 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062005149 Walker A motif; other site 883062005150 ATP binding site [chemical binding]; other site 883062005151 Walker B motif; other site 883062005152 arginine finger; other site 883062005153 thymidylate kinase; Validated; Region: tmk; PRK00698 883062005154 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 883062005155 TMP-binding site; other site 883062005156 ATP-binding site [chemical binding]; other site 883062005157 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 883062005158 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 883062005159 active site 883062005160 interdomain interaction site; other site 883062005161 putative metal-binding site [ion binding]; other site 883062005162 nucleotide binding site [chemical binding]; other site 883062005163 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 883062005164 domain I; other site 883062005165 phosphate binding site [ion binding]; other site 883062005166 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 883062005167 domain II; other site 883062005168 domain III; other site 883062005169 nucleotide binding site [chemical binding]; other site 883062005170 DNA binding groove [nucleotide binding] 883062005171 catalytic site [active] 883062005172 domain IV; other site 883062005173 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 883062005174 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 883062005175 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 883062005176 active site 883062005177 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 883062005178 putative active site [active] 883062005179 catalytic triad [active] 883062005180 PA domain; Region: PA; pfam02225 883062005181 Peptidase S8 family domain in Vpr-like proteins; Region: Peptidases_S8_subtilisin_Vpr-like; cd07474 883062005182 Haemolysin-III related; Region: HlyIII; pfam03006 883062005183 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 883062005184 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 883062005185 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 883062005186 UDP-galactopyranose mutase; Region: GLF; pfam03275 883062005187 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 883062005188 Transglycosylase; Region: Transgly; pfam00912 883062005189 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 883062005190 2-isopropylmalate synthase; Validated; Region: PRK03739 883062005191 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 883062005192 active site 883062005193 catalytic residues [active] 883062005194 metal binding site [ion binding]; metal-binding site 883062005195 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 883062005196 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 883062005197 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 883062005198 metal binding site [ion binding]; metal-binding site 883062005199 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 883062005200 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 883062005201 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 883062005202 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 883062005203 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 883062005204 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 883062005205 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 883062005206 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 883062005207 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 883062005208 putative allosteric regulatory site; other site 883062005209 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 883062005210 aspartate kinase; Reviewed; Region: PRK06635 883062005211 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 883062005212 putative catalytic residues [active] 883062005213 putative nucleotide binding site [chemical binding]; other site 883062005214 putative aspartate binding site [chemical binding]; other site 883062005215 recombination protein RecR; Reviewed; Region: recR; PRK00076 883062005216 RecR protein; Region: RecR; pfam02132 883062005217 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 883062005218 putative active site [active] 883062005219 putative metal-binding site [ion binding]; other site 883062005220 tetramer interface [polypeptide binding]; other site 883062005221 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 883062005222 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 883062005223 Walker A motif; other site 883062005224 ATP binding site [chemical binding]; other site 883062005225 Walker B motif; other site 883062005226 arginine finger; other site 883062005227 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 883062005228 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 883062005229 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 883062005230 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 883062005231 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 883062005232 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 883062005233 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 883062005234 Walker A motif; other site 883062005235 ATP binding site [chemical binding]; other site 883062005236 Walker B motif; other site 883062005237 AAA domain; Region: AAA_31; pfam13614 883062005238 polyphosphate kinase; Provisional; Region: PRK05443 883062005239 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 883062005240 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 883062005241 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 883062005242 putative domain interface [polypeptide binding]; other site 883062005243 putative active site [active] 883062005244 catalytic site [active] 883062005245 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 883062005246 putative domain interface [polypeptide binding]; other site 883062005247 putative active site [active] 883062005248 catalytic site [active] 883062005249 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 883062005250 active site 883062005251 Ap6A binding site [chemical binding]; other site 883062005252 nudix motif; other site 883062005253 metal binding site [ion binding]; metal-binding site 883062005254 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 883062005255 catalytic core [active] 883062005256 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 883062005257 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 883062005258 Probable Catalytic site; other site 883062005259 Double zinc ribbon; Region: DZR; pfam12773 883062005260 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 883062005261 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 883062005262 thiS-thiF/thiG interaction site; other site 883062005263 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 883062005264 ThiS interaction site; other site 883062005265 putative active site [active] 883062005266 tetramer interface [polypeptide binding]; other site 883062005267 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 883062005268 active site 883062005269 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 883062005270 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 883062005271 FtsX-like permease family; Region: FtsX; pfam02687 883062005272 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 883062005273 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 883062005274 ATP binding site [chemical binding]; other site 883062005275 Q-loop/lid; other site 883062005276 ABC transporter signature motif; other site 883062005277 Walker B; other site 883062005278 D-loop; other site 883062005279 H-loop/switch region; other site 883062005280 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 883062005281 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 883062005282 putative active site [active] 883062005283 putative dimer interface [polypeptide binding]; other site 883062005284 Translocation protein Sec62; Region: Sec62; cl02170 883062005285 K+ potassium transporter; Region: K_trans; pfam02705 883062005286 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 883062005287 active site 883062005288 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 883062005289 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062005290 ligand binding site [chemical binding]; other site 883062005291 dimerization interface [polypeptide binding]; other site 883062005292 MFS/sugar transport protein; Region: MFS_2; pfam13347 883062005293 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 883062005294 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 883062005295 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 883062005296 active site 883062005297 HIGH motif; other site 883062005298 KMSKS motif; other site 883062005299 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 883062005300 tRNA binding surface [nucleotide binding]; other site 883062005301 anticodon binding site; other site 883062005302 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 883062005303 Predicted methyltransferases [General function prediction only]; Region: COG0313 883062005304 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 883062005305 putative SAM binding site [chemical binding]; other site 883062005306 putative homodimer interface [polypeptide binding]; other site 883062005307 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 883062005308 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 883062005309 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 883062005310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 883062005311 motif II; other site 883062005312 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 883062005313 catalytic site [active] 883062005314 BNR repeat-like domain; Region: BNR_2; pfam13088 883062005315 Asp-box motif; other site 883062005316 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 883062005317 active site 883062005318 catalytic triad [active] 883062005319 oxyanion hole [active] 883062005320 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 883062005321 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 883062005322 catalytic site [active] 883062005323 Asp-box motif; other site 883062005324 NPCBM-associated, NEW3 domain of alpha-galactosidase; Region: NPCBM_assoc; pfam10633 883062005325 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 883062005326 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 883062005327 DNA binding residues [nucleotide binding] 883062005328 putative dimer interface [polypeptide binding]; other site 883062005329 chaperone protein DnaJ; Provisional; Region: PRK14299 883062005330 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 883062005331 HSP70 interaction site [polypeptide binding]; other site 883062005332 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 883062005333 substrate binding site [polypeptide binding]; other site 883062005334 dimer interface [polypeptide binding]; other site 883062005335 GrpE; Region: GrpE; pfam01025 883062005336 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 883062005337 dimer interface [polypeptide binding]; other site 883062005338 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 883062005339 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 883062005340 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 883062005341 nucleotide binding site [chemical binding]; other site 883062005342 NEF interaction site [polypeptide binding]; other site 883062005343 SBD interface [polypeptide binding]; other site 883062005344 alkaline phosphatase; Provisional; Region: PRK10518 883062005345 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 883062005346 active site 883062005347 dimer interface [polypeptide binding]; other site 883062005348 Transcriptional regulators [Transcription]; Region: PurR; COG1609 883062005349 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 883062005350 DNA binding site [nucleotide binding] 883062005351 domain linker motif; other site 883062005352 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 883062005353 ligand binding site [chemical binding]; other site 883062005354 dimerization interface [polypeptide binding]; other site 883062005355 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 883062005356 catalytic core [active] 883062005357 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 883062005358 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 883062005359 dimer interface [polypeptide binding]; other site 883062005360 FMN binding site [chemical binding]; other site 883062005361 NADPH bind site [chemical binding]; other site 883062005362 Phosphotransferase enzyme family; Region: APH; pfam01636 883062005363 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 883062005364 active site 883062005365 ATP binding site [chemical binding]; other site 883062005366 antibiotic binding site [chemical binding]; other site 883062005367 NAD-dependent deacetylase; Provisional; Region: PRK00481 883062005368 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 883062005369 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 883062005370 tetramer interface [polypeptide binding]; other site 883062005371 threonine dehydratase; Provisional; Region: PRK08198 883062005372 pyridoxal 5'-phosphate binding site [chemical binding]; other site 883062005373 catalytic residue [active] 883062005374 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 883062005375 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 883062005376 nucleoside/Zn binding site; other site 883062005377 dimer interface [polypeptide binding]; other site 883062005378 catalytic motif [active] 883062005379 Predicted esterase [General function prediction only]; Region: COG0400 883062005380 Serine hydrolase (FSH1); Region: FSH1; pfam03959 883062005381 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 883062005382 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 883062005383 trimer interface [polypeptide binding]; other site 883062005384 active site 883062005385 Melibiase; Region: Melibiase; pfam02065 883062005386 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 883062005387 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 883062005388 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 883062005389 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 883062005390 Soluble P-type ATPase [General function prediction only]; Region: COG4087 883062005391 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 883062005392 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 883062005393 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 883062005394 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 883062005395 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 883062005396 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 883062005397 active site 883062005398 catalytic site [active] 883062005399 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 883062005400 Cna protein B-type domain; Region: Cna_B; pfam05738 883062005401 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 883062005402 potential frameshift: common BLAST hit: gi|213691358|ref|YP_002321944.1| Integrase, catalytic region 883062005403 Helix-turn-helix domain; Region: HTH_38; pfam13936 883062005404 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 883062005405 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 883062005406 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 883062005407 Walker A/P-loop; other site 883062005408 ATP binding site [chemical binding]; other site 883062005409 Q-loop/lid; other site 883062005410 ABC transporter signature motif; other site 883062005411 Walker B; other site 883062005412 D-loop; other site 883062005413 H-loop/switch region; other site 883062005414 TOBE domain; Region: TOBE_2; pfam08402 883062005415 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 883062005416 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 883062005417 Catalytic domain of Protein Kinases; Region: PKc; cd00180 883062005418 active site 883062005419 ATP binding site [chemical binding]; other site 883062005420 substrate binding site [chemical binding]; other site 883062005421 activation loop (A-loop); other site 883062005422 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 883062005423 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 883062005424 catalytic residues [active] 883062005425 Domain of unknown function (DUF348); Region: DUF348; pfam03990 883062005426 Domain of unknown function (DUF348); Region: DUF348; pfam03990 883062005427 G5 domain; Region: G5; pfam07501 883062005428 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 883062005429 N-acetyl-D-glucosamine binding site [chemical binding]; other site 883062005430 catalytic residue [active] 883062005431 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 883062005432 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 883062005433 S-adenosylmethionine binding site [chemical binding]; other site 883062005434 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 883062005435 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 883062005436 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 883062005437 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 883062005438 active site 883062005439 NTP binding site [chemical binding]; other site 883062005440 metal binding triad [ion binding]; metal-binding site 883062005441 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 883062005442 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 883062005443 Zn2+ binding site [ion binding]; other site 883062005444 Mg2+ binding site [ion binding]; other site 883062005445 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 883062005446 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 883062005447 active site 883062005448 Ap6A binding site [chemical binding]; other site 883062005449 nudix motif; other site 883062005450 metal binding site [ion binding]; metal-binding site 883062005451 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 883062005452 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 883062005453 thioredoxin reductase; Provisional; Region: PRK10262 883062005454 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 883062005455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 883062005456 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 883062005457 ParB-like nuclease domain; Region: ParBc; pfam02195 883062005458 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 883062005459 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 883062005460 P-loop; other site 883062005461 Magnesium ion binding site [ion binding]; other site 883062005462 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 883062005463 Magnesium ion binding site [ion binding]; other site 883062005464 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 883062005465 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 883062005466 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 883062005467 G-X-X-G motif; other site 883062005468 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 883062005469 RxxxH motif; other site 883062005470 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 883062005471 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399