-- dump date 20140619_002501 -- class Genbank::misc_feature -- table misc_feature_note -- id note 326426000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 326426000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426000003 Walker A motif; other site 326426000004 ATP binding site [chemical binding]; other site 326426000005 Walker B motif; other site 326426000006 arginine finger; other site 326426000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 326426000008 DnaA box-binding interface [nucleotide binding]; other site 326426000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 326426000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 326426000011 putative DNA binding surface [nucleotide binding]; other site 326426000012 dimer interface [polypeptide binding]; other site 326426000013 beta-clamp/clamp loader binding surface; other site 326426000014 beta-clamp/translesion DNA polymerase binding surface; other site 326426000015 recF protein; Region: recf; TIGR00611 326426000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426000017 Walker A/P-loop; other site 326426000018 ATP binding site [chemical binding]; other site 326426000019 Q-loop/lid; other site 326426000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426000021 ABC transporter signature motif; other site 326426000022 Walker B; other site 326426000023 D-loop; other site 326426000024 H-loop/switch region; other site 326426000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 326426000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 326426000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426000028 Mg2+ binding site [ion binding]; other site 326426000029 G-X-G motif; other site 326426000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 326426000031 anchoring element; other site 326426000032 dimer interface [polypeptide binding]; other site 326426000033 ATP binding site [chemical binding]; other site 326426000034 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 326426000035 active site 326426000036 putative metal-binding site [ion binding]; other site 326426000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 326426000038 DNA gyrase subunit A; Validated; Region: PRK05560 326426000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 326426000040 CAP-like domain; other site 326426000041 active site 326426000042 primary dimer interface [polypeptide binding]; other site 326426000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326426000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326426000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326426000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326426000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326426000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326426000049 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 326426000050 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000051 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000052 DNA binding site [nucleotide binding] 326426000053 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326426000054 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 326426000055 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 326426000056 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 326426000057 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 326426000058 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 326426000059 VanZ like family; Region: VanZ; cl01971 326426000060 glutamate dehydrogenase; Provisional; Region: PRK09414 326426000061 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 326426000062 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 326426000063 NAD(P) binding site [chemical binding]; other site 326426000064 Protein of unknown function DUF45; Region: DUF45; pfam01863 326426000065 AAA domain; Region: AAA_14; pfam13173 326426000066 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 326426000067 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 326426000068 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 326426000069 dimerization interface [polypeptide binding]; other site 326426000070 DPS ferroxidase diiron center [ion binding]; other site 326426000071 ion pore; other site 326426000072 Protein of unknown function, DUF624; Region: DUF624; pfam04854 326426000073 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000074 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000075 DNA binding site [nucleotide binding] 326426000076 domain linker motif; other site 326426000077 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 326426000078 putative dimerization interface [polypeptide binding]; other site 326426000079 putative ligand binding site [chemical binding]; other site 326426000080 Glycosyl hydrolase family 32; Region: GH32_Aec43_like; cd08995 326426000081 active site 326426000082 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 326426000083 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326426000084 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 326426000085 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 326426000086 putative active site [active] 326426000087 putative catalytic site [active] 326426000088 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000089 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000090 DNA binding site [nucleotide binding] 326426000091 domain linker motif; other site 326426000092 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426000093 ligand binding site [chemical binding]; other site 326426000094 dimerization interface [polypeptide binding]; other site 326426000095 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 326426000096 Helix-turn-helix domain; Region: HTH_38; pfam13936 326426000097 Integrase core domain; Region: rve; pfam00665 326426000098 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426000099 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000100 dimer interface [polypeptide binding]; other site 326426000101 conserved gate region; other site 326426000102 putative PBP binding loops; other site 326426000103 ABC-ATPase subunit interface; other site 326426000104 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000105 putative PBP binding loops; other site 326426000106 ABC-ATPase subunit interface; other site 326426000107 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 326426000108 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000109 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000110 DNA binding site [nucleotide binding] 326426000111 domain linker motif; other site 326426000112 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426000113 ligand binding site [chemical binding]; other site 326426000114 dimerization interface [polypeptide binding]; other site 326426000115 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326426000116 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 326426000117 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 326426000118 dimerization interface [polypeptide binding]; other site 326426000119 DPS ferroxidase diiron center [ion binding]; other site 326426000120 ion pore; other site 326426000121 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326426000122 Domain of unknown function DUF21; Region: DUF21; pfam01595 326426000123 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326426000124 Transporter associated domain; Region: CorC_HlyC; smart01091 326426000125 AAA ATPase domain; Region: AAA_16; pfam13191 326426000126 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 326426000127 active site clefts [active] 326426000128 zinc binding site [ion binding]; other site 326426000129 dimer interface [polypeptide binding]; other site 326426000130 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 326426000131 peroxiredoxin; Region: AhpC; TIGR03137 326426000132 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 326426000133 dimer interface [polypeptide binding]; other site 326426000134 decamer (pentamer of dimers) interface [polypeptide binding]; other site 326426000135 catalytic triad [active] 326426000136 peroxidatic and resolving cysteines [active] 326426000137 putative alkyl hydroperoxide reductase F subunit; Region: AhpF_homolog; TIGR03143 326426000138 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326426000139 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326426000140 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 326426000141 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 326426000142 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 326426000143 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326426000144 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 326426000145 GAF domain; Region: GAF_3; pfam13492 326426000146 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813 326426000147 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326426000148 Predicted membrane protein [Function unknown]; Region: COG4267 326426000149 CotH protein; Region: CotH; pfam08757 326426000150 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 326426000151 putative metal binding residues [ion binding]; other site 326426000152 signature motif; other site 326426000153 dimer interface [polypeptide binding]; other site 326426000154 active site 326426000155 polyP binding site; other site 326426000156 substrate binding site [chemical binding]; other site 326426000157 acceptor-phosphate pocket; other site 326426000158 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326426000159 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 326426000160 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326426000161 metal binding site [ion binding]; metal-binding site 326426000162 active site 326426000163 I-site; other site 326426000164 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 326426000165 AAA domain; Region: AAA_14; pfam13173 326426000166 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 326426000167 Divergent AAA domain; Region: AAA_4; pfam04326 326426000168 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 326426000169 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 326426000170 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 326426000171 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 326426000172 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 326426000173 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 326426000174 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 326426000175 Na binding site [ion binding]; other site 326426000176 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 326426000177 Amidohydrolase family; Region: Amidohydro_3; pfam07969 326426000178 active site 326426000179 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 326426000180 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 326426000181 active site 326426000182 HIGH motif; other site 326426000183 dimer interface [polypeptide binding]; other site 326426000184 KMSKS motif; other site 326426000185 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 326426000186 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 326426000187 homodimer interface [polypeptide binding]; other site 326426000188 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 326426000189 active site pocket [active] 326426000190 Rhomboid family; Region: Rhomboid; pfam01694 326426000191 putative septation inhibitor protein; Reviewed; Region: PRK02251 326426000192 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 326426000193 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 326426000194 active site 326426000195 catalytic site [active] 326426000196 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 326426000197 Glutamine amidotransferase class-I; Region: GATase; pfam00117 326426000198 glutamine binding [chemical binding]; other site 326426000199 catalytic triad [active] 326426000200 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326426000201 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326426000202 active site 326426000203 ATP binding site [chemical binding]; other site 326426000204 substrate binding site [chemical binding]; other site 326426000205 activation loop (A-loop); other site 326426000206 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326426000207 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326426000208 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326426000209 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326426000210 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326426000211 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326426000212 active site 326426000213 ATP binding site [chemical binding]; other site 326426000214 substrate binding site [chemical binding]; other site 326426000215 activation loop (A-loop); other site 326426000216 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326426000217 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 326426000218 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 326426000219 active site 326426000220 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326426000221 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326426000222 phosphopeptide binding site; other site 326426000223 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 326426000224 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326426000225 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326426000226 phosphopeptide binding site; other site 326426000227 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 326426000228 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 326426000229 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326426000230 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 326426000231 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 326426000232 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 326426000233 putative dimer interface [polypeptide binding]; other site 326426000234 aromatic amino acid exporter; Provisional; Region: PRK11689 326426000235 Putative esterase; Region: Esterase; pfam00756 326426000236 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 326426000237 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 326426000238 methionine sulfoxide reductase B; Provisional; Region: PRK00222 326426000239 SelR domain; Region: SelR; pfam01641 326426000240 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; cl17869 326426000241 Fic family protein [Function unknown]; Region: COG3177 326426000242 Fic/DOC family; Region: Fic; pfam02661 326426000243 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 326426000244 putative DNA binding helix; other site 326426000245 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326426000246 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326426000247 active site 326426000248 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 326426000249 PLD-like domain; Region: PLDc_2; pfam13091 326426000250 putative homodimer interface [polypeptide binding]; other site 326426000251 putative active site [active] 326426000252 catalytic site [active] 326426000253 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326426000254 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426000255 ATP binding site [chemical binding]; other site 326426000256 putative Mg++ binding site [ion binding]; other site 326426000257 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426000258 nucleotide binding region [chemical binding]; other site 326426000259 ATP-binding site [chemical binding]; other site 326426000260 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 326426000261 hypothetical protein; Provisional; Region: PRK01119 326426000262 Haemolysin-III related; Region: HlyIII; pfam03006 326426000263 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 326426000264 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 326426000265 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 326426000266 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 326426000267 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 326426000268 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 326426000269 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326426000270 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 326426000271 ferredoxin-NADP+ reductase; Region: PLN02852 326426000272 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326426000273 heat shock protein HtpX; Provisional; Region: PRK03072 326426000274 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 326426000275 EamA-like transporter family; Region: EamA; pfam00892 326426000276 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 326426000277 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 326426000278 active site 326426000279 intersubunit interface [polypeptide binding]; other site 326426000280 zinc binding site [ion binding]; other site 326426000281 Na+ binding site [ion binding]; other site 326426000282 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 326426000283 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 326426000284 GDP-binding site [chemical binding]; other site 326426000285 ACT binding site; other site 326426000286 IMP binding site; other site 326426000287 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 326426000288 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 326426000289 Cl- selectivity filter; other site 326426000290 Cl- binding residues [ion binding]; other site 326426000291 pore gating glutamate residue; other site 326426000292 dimer interface [polypeptide binding]; other site 326426000293 H+/Cl- coupling transport residue; other site 326426000294 TrkA-C domain; Region: TrkA_C; pfam02080 326426000295 CrcB-like protein; Region: CRCB; pfam02537 326426000296 CrcB-like protein; Region: CRCB; pfam02537 326426000297 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000298 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000299 DNA binding site [nucleotide binding] 326426000300 domain linker motif; other site 326426000301 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326426000302 sucrose phosphorylase; Provisional; Region: PRK13840 326426000303 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 326426000304 active site 326426000305 homodimer interface [polypeptide binding]; other site 326426000306 catalytic site [active] 326426000307 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 326426000308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426000309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000311 DNA binding site [nucleotide binding] 326426000312 domain linker motif; other site 326426000313 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 326426000314 dimerization interface [polypeptide binding]; other site 326426000315 ligand binding site [chemical binding]; other site 326426000316 sodium binding site [ion binding]; other site 326426000317 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426000318 metabolite-proton symporter; Region: 2A0106; TIGR00883 326426000319 putative substrate translocation pore; other site 326426000320 ketol-acid reductoisomerase; Provisional; Region: PRK05479 326426000321 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 326426000322 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 326426000323 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000324 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000325 DNA binding site [nucleotide binding] 326426000326 domain linker motif; other site 326426000327 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326426000328 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326426000329 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426000330 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 326426000331 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000332 dimer interface [polypeptide binding]; other site 326426000333 conserved gate region; other site 326426000334 ABC-ATPase subunit interface; other site 326426000335 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426000336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000337 dimer interface [polypeptide binding]; other site 326426000338 conserved gate region; other site 326426000339 putative PBP binding loops; other site 326426000340 ABC-ATPase subunit interface; other site 326426000341 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 326426000342 beta-galactosidase; Region: BGL; TIGR03356 326426000343 ketol-acid reductoisomerase; Provisional; Region: PRK05479 326426000344 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 326426000345 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 326426000346 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 326426000347 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 326426000348 active site 326426000349 catalytic site [active] 326426000350 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 326426000351 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000352 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000353 DNA binding site [nucleotide binding] 326426000354 domain linker motif; other site 326426000355 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426000356 ligand binding site [chemical binding]; other site 326426000357 dimerization interface [polypeptide binding]; other site 326426000358 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 326426000359 Cna protein B-type domain; Region: Cna_B; pfam05738 326426000360 Cna protein B-type domain; Region: Cna_B; pfam05738 326426000361 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 326426000362 Cna protein B-type domain; Region: Cna_B; pfam05738 326426000363 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 326426000364 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 326426000365 active site 326426000366 catalytic site [active] 326426000367 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 326426000368 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 326426000369 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 326426000370 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 326426000371 active site 326426000372 catalytic site [active] 326426000373 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 326426000374 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 326426000375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000376 dimer interface [polypeptide binding]; other site 326426000377 conserved gate region; other site 326426000378 putative PBP binding loops; other site 326426000379 ABC-ATPase subunit interface; other site 326426000380 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426000381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 326426000382 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000383 dimer interface [polypeptide binding]; other site 326426000384 conserved gate region; other site 326426000385 ABC-ATPase subunit interface; other site 326426000386 TraX protein; Region: TraX; cl05434 326426000387 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000388 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000389 DNA binding site [nucleotide binding] 326426000390 domain linker motif; other site 326426000391 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426000392 ligand binding site [chemical binding]; other site 326426000393 dimerization interface [polypeptide binding]; other site 326426000394 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 326426000395 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 326426000396 active site 326426000397 Ca binding site [ion binding]; other site 326426000398 catalytic site [active] 326426000399 Aamy_C domain; Region: Aamy_C; smart00632 326426000400 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 326426000401 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 326426000402 carbohydrate binding site [chemical binding]; other site 326426000403 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 326426000404 carbohydrate binding site [chemical binding]; other site 326426000405 pullulanase, type I; Region: pulA_typeI; TIGR02104 326426000406 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 326426000407 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 326426000408 Ca binding site [ion binding]; other site 326426000409 active site 326426000410 catalytic site [active] 326426000411 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 326426000412 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326426000413 nucleotide binding site [chemical binding]; other site 326426000414 GrpE; Region: GrpE; pfam01025 326426000415 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 326426000416 dimer interface [polypeptide binding]; other site 326426000417 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 326426000418 chaperone protein DnaJ; Provisional; Region: PRK14299 326426000419 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 326426000420 HSP70 interaction site [polypeptide binding]; other site 326426000421 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 326426000422 substrate binding site [polypeptide binding]; other site 326426000423 dimer interface [polypeptide binding]; other site 326426000424 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 326426000425 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326426000426 DNA binding residues [nucleotide binding] 326426000427 putative dimer interface [polypeptide binding]; other site 326426000428 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08642 326426000429 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326426000430 NAD(P) binding site [chemical binding]; other site 326426000431 active site 326426000432 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 326426000433 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426000434 motif II; other site 326426000435 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 326426000436 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326426000437 helicase/secretion neighborhood CpaE-like protein; Region: CpaE_hom_Actino; TIGR03815 326426000438 Type II/IV secretion system protein; Region: T2SE; pfam00437 326426000439 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 326426000440 ATP binding site [chemical binding]; other site 326426000441 Walker A motif; other site 326426000442 hexamer interface [polypeptide binding]; other site 326426000443 Walker B motif; other site 326426000444 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 326426000445 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 326426000446 TadE-like protein; Region: TadE; pfam07811 326426000447 diacylglycerol kinase; Reviewed; Region: PRK11914 326426000448 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 326426000449 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326426000450 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326426000451 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 326426000452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426000453 Walker A motif; other site 326426000454 ATP binding site [chemical binding]; other site 326426000455 Walker B motif; other site 326426000456 arginine finger; other site 326426000457 recombination protein RecR; Reviewed; Region: recR; PRK00076 326426000458 RecR protein; Region: RecR; pfam02132 326426000459 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 326426000460 putative active site [active] 326426000461 putative metal-binding site [ion binding]; other site 326426000462 tetramer interface [polypeptide binding]; other site 326426000463 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 326426000464 active site 326426000465 catalytic site [active] 326426000466 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 326426000467 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 326426000468 aspartate kinase; Reviewed; Region: PRK06635 326426000469 AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246 326426000470 putative catalytic residues [active] 326426000471 putative nucleotide binding site [chemical binding]; other site 326426000472 putative aspartate binding site [chemical binding]; other site 326426000473 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 326426000474 putative allosteric regulatory site; other site 326426000475 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 326426000476 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 326426000477 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 326426000478 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 326426000479 transposase/IS protein; Provisional; Region: PRK09183 326426000480 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426000481 Walker A motif; other site 326426000482 ATP binding site [chemical binding]; other site 326426000483 Walker B motif; other site 326426000484 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426000485 Integrase core domain; Region: rve; pfam00665 326426000486 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 326426000487 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326426000488 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 326426000489 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 326426000490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000491 dimer interface [polypeptide binding]; other site 326426000492 conserved gate region; other site 326426000493 putative PBP binding loops; other site 326426000494 ABC-ATPase subunit interface; other site 326426000495 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 326426000496 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426000497 Walker A/P-loop; other site 326426000498 ATP binding site [chemical binding]; other site 326426000499 Q-loop/lid; other site 326426000500 ABC transporter signature motif; other site 326426000501 Walker B; other site 326426000502 D-loop; other site 326426000503 H-loop/switch region; other site 326426000504 Uncharacterized conserved protein [Function unknown]; Region: COG3379 326426000505 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426000506 Integrase core domain; Region: rve; pfam00665 326426000507 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 326426000508 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426000509 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 326426000510 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 326426000511 putative active site cavity [active] 326426000512 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 326426000513 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326426000514 Protein of unknown function (DUF3089); Region: DUF3089; pfam11288 326426000515 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 326426000516 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326426000517 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326426000518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000519 dimer interface [polypeptide binding]; other site 326426000520 conserved gate region; other site 326426000521 putative PBP binding loops; other site 326426000522 ABC-ATPase subunit interface; other site 326426000523 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 326426000524 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000525 dimer interface [polypeptide binding]; other site 326426000526 conserved gate region; other site 326426000527 putative PBP binding loops; other site 326426000528 ABC-ATPase subunit interface; other site 326426000529 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 326426000530 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326426000531 Walker A/P-loop; other site 326426000532 ATP binding site [chemical binding]; other site 326426000533 Q-loop/lid; other site 326426000534 ABC transporter signature motif; other site 326426000535 Walker B; other site 326426000536 D-loop; other site 326426000537 H-loop/switch region; other site 326426000538 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 326426000539 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 326426000540 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326426000541 Walker A/P-loop; other site 326426000542 ATP binding site [chemical binding]; other site 326426000543 Q-loop/lid; other site 326426000544 ABC transporter signature motif; other site 326426000545 Walker B; other site 326426000546 D-loop; other site 326426000547 H-loop/switch region; other site 326426000548 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326426000549 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 326426000550 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 326426000551 inhibitor site; inhibition site 326426000552 active site 326426000553 dimer interface [polypeptide binding]; other site 326426000554 catalytic residue [active] 326426000555 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 326426000556 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 326426000557 active site 326426000558 trimer interface [polypeptide binding]; other site 326426000559 allosteric site; other site 326426000560 active site lid [active] 326426000561 hexamer (dimer of trimers) interface [polypeptide binding]; other site 326426000562 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 326426000563 catalytic site [active] 326426000564 Asp-box motif; other site 326426000565 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 326426000566 AAA domain; Region: AAA_14; pfam13173 326426000567 Transcriptional regulators [Transcription]; Region: FadR; COG2186 326426000568 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326426000569 DNA-binding site [nucleotide binding]; DNA binding site 326426000570 FCD domain; Region: FCD; pfam07729 326426000571 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326426000572 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326426000573 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 326426000574 2-isopropylmalate synthase; Validated; Region: PRK03739 326426000575 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 326426000576 active site 326426000577 catalytic residues [active] 326426000578 metal binding site [ion binding]; metal-binding site 326426000579 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 326426000580 Transglycosylase; Region: Transgly; pfam00912 326426000581 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 326426000582 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 326426000583 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 326426000584 active site 326426000585 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 326426000586 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 326426000587 active site 326426000588 interdomain interaction site; other site 326426000589 putative metal-binding site [ion binding]; other site 326426000590 nucleotide binding site [chemical binding]; other site 326426000591 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 326426000592 domain I; other site 326426000593 phosphate binding site [ion binding]; other site 326426000594 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 326426000595 domain II; other site 326426000596 domain III; other site 326426000597 nucleotide binding site [chemical binding]; other site 326426000598 DNA binding groove [nucleotide binding] 326426000599 catalytic site [active] 326426000600 domain IV; other site 326426000601 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 326426000602 thymidylate kinase; Validated; Region: tmk; PRK00698 326426000603 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 326426000604 TMP-binding site; other site 326426000605 ATP-binding site [chemical binding]; other site 326426000606 DNA polymerase III subunit delta'; Validated; Region: PRK07940 326426000607 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426000608 Walker A motif; other site 326426000609 ATP binding site [chemical binding]; other site 326426000610 Walker B motif; other site 326426000611 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cl17402 326426000612 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000613 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426000614 dimerization interface [polypeptide binding]; other site 326426000615 ligand binding site [chemical binding]; other site 326426000616 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 326426000617 dimerization domain swap beta strand [polypeptide binding]; other site 326426000618 regulatory protein interface [polypeptide binding]; other site 326426000619 active site 326426000620 regulatory phosphorylation site [posttranslational modification]; other site 326426000621 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 326426000622 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 326426000623 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 326426000624 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 326426000625 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 326426000626 substrate binding site [chemical binding]; other site 326426000627 Peptidase family C69; Region: Peptidase_C69; pfam03577 326426000628 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326426000629 Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759 326426000630 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 326426000631 Predicted membrane protein [Function unknown]; Region: COG2246 326426000632 GtrA-like protein; Region: GtrA; pfam04138 326426000633 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 326426000634 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426000635 catalytic core [active] 326426000636 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 326426000637 Protein of unknown function (DUF805); Region: DUF805; pfam05656 326426000638 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 326426000639 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 326426000640 HIGH motif; other site 326426000641 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 326426000642 active site 326426000643 KMSKS motif; other site 326426000644 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 326426000645 Predicted transcriptional regulators [Transcription]; Region: COG1733 326426000646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326426000647 dimerization interface [polypeptide binding]; other site 326426000648 putative DNA binding site [nucleotide binding]; other site 326426000649 putative Zn2+ binding site [ion binding]; other site 326426000650 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 326426000651 NADH(P)-binding; Region: NAD_binding_10; pfam13460 326426000652 NAD(P) binding site [chemical binding]; other site 326426000653 active site 326426000654 Divergent AAA domain; Region: AAA_4; pfam04326 326426000655 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 326426000656 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 326426000657 methyl viologen resistance protein SmvA; Provisional; Region: PRK14995 326426000658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426000659 putative substrate translocation pore; other site 326426000660 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426000661 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326426000662 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 326426000663 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326426000664 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 326426000665 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 326426000666 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 326426000667 putative NADP binding site [chemical binding]; other site 326426000668 active site 326426000669 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 326426000670 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 326426000671 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326426000672 active site 326426000673 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 326426000674 active site 326426000675 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426000676 Integrase core domain; Region: rve; pfam00665 326426000677 transposase/IS protein; Provisional; Region: PRK09183 326426000678 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426000679 Walker A motif; other site 326426000680 ATP binding site [chemical binding]; other site 326426000681 Walker B motif; other site 326426000682 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326426000683 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326426000684 WHG domain; Region: WHG; pfam13305 326426000685 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 326426000686 HNH endonuclease; Region: HNH_2; pfam13391 326426000687 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 326426000688 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 326426000689 cofactor binding site; other site 326426000690 DNA binding site [nucleotide binding] 326426000691 substrate interaction site [chemical binding]; other site 326426000692 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 326426000693 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 326426000694 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 326426000695 active site 326426000696 metal binding site [ion binding]; metal-binding site 326426000697 interdomain interaction site; other site 326426000698 AAA domain; Region: AAA_25; pfam13481 326426000699 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 326426000700 Walker A motif; other site 326426000701 ATP binding site [chemical binding]; other site 326426000702 Walker B motif; other site 326426000703 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 326426000704 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326426000705 active site 326426000706 Int/Topo IB signature motif; other site 326426000707 DNA binding site [nucleotide binding] 326426000708 MgtE intracellular N domain; Region: MgtE_N; smart00924 326426000709 Iron permease FTR1 family; Region: FTR1; cl00475 326426000710 Fe2+ transport protein; Region: Iron_transport; pfam10634 326426000711 Predicted membrane protein [Function unknown]; Region: COG4393 326426000712 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 326426000713 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426000714 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 326426000715 FtsX-like permease family; Region: FtsX; pfam02687 326426000716 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 326426000717 FtsX-like permease family; Region: FtsX; pfam02687 326426000718 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426000719 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426000720 Walker A/P-loop; other site 326426000721 ATP binding site [chemical binding]; other site 326426000722 Q-loop/lid; other site 326426000723 ABC transporter signature motif; other site 326426000724 Walker B; other site 326426000725 D-loop; other site 326426000726 H-loop/switch region; other site 326426000727 FMN-binding domain; Region: FMN_bind; cl01081 326426000728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326426000729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326426000730 Predicted membrane protein [Function unknown]; Region: COG1511 326426000731 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 326426000732 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 326426000733 Predicted membrane protein [Function unknown]; Region: COG1511 326426000734 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 326426000735 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 326426000736 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326426000737 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 326426000738 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 326426000739 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 326426000740 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 326426000741 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 326426000742 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 326426000743 putative active site [active] 326426000744 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 326426000745 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 326426000746 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 326426000747 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 326426000748 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 326426000749 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 326426000750 Peptidase family C69; Region: Peptidase_C69; pfam03577 326426000751 putative glycosyl transferase; Provisional; Region: PRK10073 326426000752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326426000753 active site 326426000754 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326426000755 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326426000756 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 326426000757 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 326426000758 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326426000759 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 326426000760 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 326426000761 Nitrogen regulatory protein P-II; Region: P-II; smart00938 326426000762 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 326426000763 metal binding triad; other site 326426000764 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 326426000765 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 326426000766 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 326426000767 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 326426000768 replicative DNA helicase; Region: DnaB; TIGR00665 326426000769 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 326426000770 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 326426000771 Walker A motif; other site 326426000772 ATP binding site [chemical binding]; other site 326426000773 Walker B motif; other site 326426000774 DNA binding loops [nucleotide binding] 326426000775 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 326426000776 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326426000777 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 326426000778 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 326426000779 catalytic triad [active] 326426000780 Uncharacterized conserved protein [Function unknown]; Region: COG3937 326426000781 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 326426000782 ABC1 family; Region: ABC1; pfam03109 326426000783 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 326426000784 active site 326426000785 ATP binding site [chemical binding]; other site 326426000786 Nucleotidyl transferase of unknown function (DUF2204); Region: DUF2204; cl17690 326426000787 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 326426000788 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326426000789 catalytic residue [active] 326426000790 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 326426000791 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 326426000792 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 326426000793 dimer interface [polypeptide binding]; other site 326426000794 ssDNA binding site [nucleotide binding]; other site 326426000795 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326426000796 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 326426000797 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 326426000798 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 326426000799 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 326426000800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426000801 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 326426000802 Walker A/P-loop; other site 326426000803 ATP binding site [chemical binding]; other site 326426000804 Q-loop/lid; other site 326426000805 ABC transporter signature motif; other site 326426000806 Walker B; other site 326426000807 D-loop; other site 326426000808 H-loop/switch region; other site 326426000809 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326426000810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426000811 phosphorylation site [posttranslational modification] 326426000812 intermolecular recognition site; other site 326426000813 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326426000814 DNA binding residues [nucleotide binding] 326426000815 dimerization interface [polypeptide binding]; other site 326426000816 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326426000817 glucuronide transporter; Provisional; Region: PRK09848 326426000818 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326426000819 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 326426000820 amphipathic channel; other site 326426000821 Asn-Pro-Ala signature motifs; other site 326426000822 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 326426000823 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 326426000824 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326426000825 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426000826 active site 326426000827 motif I; other site 326426000828 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 326426000829 motif II; other site 326426000830 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 326426000831 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 326426000832 putative homodimer interface [polypeptide binding]; other site 326426000833 putative homotetramer interface [polypeptide binding]; other site 326426000834 putative allosteric switch controlling residues; other site 326426000835 putative metal binding site [ion binding]; other site 326426000836 putative homodimer-homodimer interface [polypeptide binding]; other site 326426000837 RmuC family; Region: RmuC; pfam02646 326426000838 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 326426000839 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 326426000840 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 326426000841 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326426000842 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426000843 Walker A/P-loop; other site 326426000844 ATP binding site [chemical binding]; other site 326426000845 Q-loop/lid; other site 326426000846 ABC transporter signature motif; other site 326426000847 Walker B; other site 326426000848 D-loop; other site 326426000849 H-loop/switch region; other site 326426000850 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 326426000851 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 326426000852 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 326426000853 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 326426000854 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 326426000855 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 326426000856 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 326426000857 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 326426000858 GatB domain; Region: GatB_Yqey; pfam02637 326426000859 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326426000860 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326426000861 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 326426000862 hypothetical protein; Provisional; Region: PRK07208 326426000863 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326426000864 UDP-galactopyranose mutase; Region: GLF; pfam03275 326426000865 transcription termination factor Rho; Provisional; Region: PRK12678 326426000866 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 326426000867 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 326426000868 RNA binding site [nucleotide binding]; other site 326426000869 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 326426000870 Walker A motif; other site 326426000871 ATP binding site [chemical binding]; other site 326426000872 Walker B motif; other site 326426000873 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426000874 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426000875 DNA binding site [nucleotide binding] 326426000876 domain linker motif; other site 326426000877 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426000878 dimerization interface [polypeptide binding]; other site 326426000879 ligand binding site [chemical binding]; other site 326426000880 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 326426000881 MFS/sugar transport protein; Region: MFS_2; pfam13347 326426000882 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 326426000883 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 326426000884 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 326426000885 chorismate mutase; Provisional; Region: PRK09239 326426000886 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 326426000887 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326426000888 active site 326426000889 HIGH motif; other site 326426000890 nucleotide binding site [chemical binding]; other site 326426000891 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326426000892 active site 326426000893 KMSKS motif; other site 326426000894 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 326426000895 tRNA binding surface [nucleotide binding]; other site 326426000896 anticodon binding site; other site 326426000897 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 326426000898 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326426000899 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 326426000900 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326426000901 minor groove reading motif; other site 326426000902 helix-hairpin-helix signature motif; other site 326426000903 substrate binding pocket [chemical binding]; other site 326426000904 active site 326426000905 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 326426000906 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326426000907 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326426000908 DNA binding site [nucleotide binding] 326426000909 Predicted membrane protein [Function unknown]; Region: COG1971 326426000910 Domain of unknown function DUF; Region: DUF204; pfam02659 326426000911 Domain of unknown function DUF; Region: DUF204; pfam02659 326426000912 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 326426000913 dimer interface [polypeptide binding]; other site 326426000914 substrate binding site [chemical binding]; other site 326426000915 metal binding sites [ion binding]; metal-binding site 326426000916 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 326426000917 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 326426000918 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 326426000919 active site 326426000920 homodimer interface [polypeptide binding]; other site 326426000921 catalytic site [active] 326426000922 acceptor binding site [chemical binding]; other site 326426000923 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426000924 Integrase core domain; Region: rve; pfam00665 326426000925 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 326426000926 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000927 dimer interface [polypeptide binding]; other site 326426000928 conserved gate region; other site 326426000929 putative PBP binding loops; other site 326426000930 ABC-ATPase subunit interface; other site 326426000931 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426000932 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426000933 dimer interface [polypeptide binding]; other site 326426000934 conserved gate region; other site 326426000935 putative PBP binding loops; other site 326426000936 ABC-ATPase subunit interface; other site 326426000937 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426000938 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 326426000939 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 326426000940 Protein of unknown function, DUF624; Region: DUF624; pfam04854 326426000941 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326426000942 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326426000943 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 326426000944 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 326426000945 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 326426000946 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 326426000947 Probable transposase; Region: OrfB_IS605; pfam01385 326426000948 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 326426000949 Transposase, Mutator family; Region: Transposase_mut; pfam00872 326426000950 MULE transposase domain; Region: MULE; pfam10551 326426000951 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 326426000952 metal binding site [ion binding]; metal-binding site 326426000953 Phage capsid family; Region: Phage_capsid; pfam05065 326426000954 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 326426000955 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 326426000956 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326426000957 active site 326426000958 DNA binding site [nucleotide binding] 326426000959 Int/Topo IB signature motif; other site 326426000960 homoserine O-succinyltransferase; Provisional; Region: PRK05368 326426000961 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 326426000962 proposed active site lysine [active] 326426000963 conserved cys residue [active] 326426000964 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 326426000965 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 326426000966 ATP synthase subunit C; Region: ATP-synt_C; cl00466 326426000967 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 326426000968 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 326426000969 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 326426000970 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 326426000971 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 326426000972 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 326426000973 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 326426000974 beta subunit interaction interface [polypeptide binding]; other site 326426000975 Walker A motif; other site 326426000976 ATP binding site [chemical binding]; other site 326426000977 Walker B motif; other site 326426000978 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 326426000979 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 326426000980 core domain interface [polypeptide binding]; other site 326426000981 delta subunit interface [polypeptide binding]; other site 326426000982 epsilon subunit interface [polypeptide binding]; other site 326426000983 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 326426000984 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 326426000985 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 326426000986 alpha subunit interaction interface [polypeptide binding]; other site 326426000987 Walker A motif; other site 326426000988 ATP binding site [chemical binding]; other site 326426000989 Walker B motif; other site 326426000990 inhibitor binding site; inhibition site 326426000991 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 326426000992 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 326426000993 gamma subunit interface [polypeptide binding]; other site 326426000994 epsilon subunit interface [polypeptide binding]; other site 326426000995 LBP interface [polypeptide binding]; other site 326426000996 hypothetical protein; Provisional; Region: PRK03298 326426000997 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 326426000998 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 326426000999 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 326426001000 CYTH-like Clostridium thermocellum TTM-like subgroup 1; Region: CYTH-like_CthTTM-like_1; cd07891 326426001001 putative active site [active] 326426001002 putative metal binding residues [ion binding]; other site 326426001003 signature motif; other site 326426001004 putative dimer interface [polypeptide binding]; other site 326426001005 putative phosphate binding site [ion binding]; other site 326426001006 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 326426001007 homotrimer interaction site [polypeptide binding]; other site 326426001008 putative active site [active] 326426001009 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326426001010 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326426001011 putative acyl-acceptor binding pocket; other site 326426001012 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 326426001013 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 326426001014 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 326426001015 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 326426001016 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 326426001017 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326426001018 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326426001019 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 326426001020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 326426001021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001022 dimer interface [polypeptide binding]; other site 326426001023 conserved gate region; other site 326426001024 putative PBP binding loops; other site 326426001025 ABC-ATPase subunit interface; other site 326426001026 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 326426001027 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426001028 Walker A/P-loop; other site 326426001029 ATP binding site [chemical binding]; other site 326426001030 Q-loop/lid; other site 326426001031 ABC transporter signature motif; other site 326426001032 Walker B; other site 326426001033 D-loop; other site 326426001034 H-loop/switch region; other site 326426001035 TOBE domain; Region: TOBE_2; pfam08402 326426001036 CAAX protease self-immunity; Region: Abi; pfam02517 326426001037 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 326426001038 Mechanosensitive ion channel; Region: MS_channel; pfam00924 326426001039 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 326426001040 Aspartase; Region: Aspartase; cd01357 326426001041 active sites [active] 326426001042 tetramer interface [polypeptide binding]; other site 326426001043 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326426001044 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 326426001045 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326426001046 FeS/SAM binding site; other site 326426001047 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 326426001048 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426001049 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426001050 DNA binding site [nucleotide binding] 326426001051 domain linker motif; other site 326426001052 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426001053 dimerization interface [polypeptide binding]; other site 326426001054 ligand binding site [chemical binding]; other site 326426001055 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 326426001056 Sulfatase; Region: Sulfatase; pfam00884 326426001057 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426001058 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426001059 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 326426001060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001061 dimer interface [polypeptide binding]; other site 326426001062 conserved gate region; other site 326426001063 putative PBP binding loops; other site 326426001064 ABC-ATPase subunit interface; other site 326426001065 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426001066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001067 dimer interface [polypeptide binding]; other site 326426001068 conserved gate region; other site 326426001069 putative PBP binding loops; other site 326426001070 ABC-ATPase subunit interface; other site 326426001071 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 326426001072 AAA domain; Region: AAA_14; pfam13173 326426001073 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 326426001074 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326426001075 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 326426001076 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 326426001077 DNA binding site [nucleotide binding] 326426001078 active site 326426001079 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 326426001080 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 326426001081 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 326426001082 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 326426001083 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 326426001084 metal ion-dependent adhesion site (MIDAS); other site 326426001085 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 326426001086 domain interaction interfaces [polypeptide binding]; other site 326426001087 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 326426001088 Cna protein B-type domain; Region: Cna_B; pfam05738 326426001089 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 326426001090 16S/18S rRNA binding site [nucleotide binding]; other site 326426001091 S13e-L30e interaction site [polypeptide binding]; other site 326426001092 25S rRNA binding site [nucleotide binding]; other site 326426001093 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 326426001094 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 326426001095 oligomer interface [polypeptide binding]; other site 326426001096 RNA binding site [nucleotide binding]; other site 326426001097 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 326426001098 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 326426001099 RNase E interface [polypeptide binding]; other site 326426001100 trimer interface [polypeptide binding]; other site 326426001101 active site 326426001102 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 326426001103 putative nucleic acid binding region [nucleotide binding]; other site 326426001104 G-X-X-G motif; other site 326426001105 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 326426001106 RNA binding site [nucleotide binding]; other site 326426001107 domain interface; other site 326426001108 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426001109 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426001110 Walker A/P-loop; other site 326426001111 ATP binding site [chemical binding]; other site 326426001112 Q-loop/lid; other site 326426001113 ABC transporter signature motif; other site 326426001114 Walker B; other site 326426001115 D-loop; other site 326426001116 H-loop/switch region; other site 326426001117 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 326426001118 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 326426001119 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 326426001120 Predicted membrane protein [Function unknown]; Region: COG4907 326426001121 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326426001122 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326426001123 active site 326426001124 catalytic tetrad [active] 326426001125 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 326426001126 active site 326426001127 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 326426001128 RimM N-terminal domain; Region: RimM; pfam01782 326426001129 hypothetical protein; Provisional; Region: PRK02821 326426001130 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 326426001131 G-X-X-G motif; other site 326426001132 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 326426001133 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 326426001134 putative catalytic site [active] 326426001135 putative metal binding site [ion binding]; other site 326426001136 putative phosphate binding site [ion binding]; other site 326426001137 signal recognition particle protein; Provisional; Region: PRK10867 326426001138 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 326426001139 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 326426001140 P loop; other site 326426001141 GTP binding site [chemical binding]; other site 326426001142 Signal peptide binding domain; Region: SRP_SPB; pfam02978 326426001143 Cation efflux family; Region: Cation_efflux; pfam01545 326426001144 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 326426001145 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326426001146 active site 326426001147 HIGH motif; other site 326426001148 nucleotide binding site [chemical binding]; other site 326426001149 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 326426001150 KMSKS motif; other site 326426001151 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 326426001152 tRNA binding surface [nucleotide binding]; other site 326426001153 anticodon binding site; other site 326426001154 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 326426001155 catalytic triad [active] 326426001156 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426001157 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326426001158 ABC transporter; Region: ABC_tran_2; pfam12848 326426001159 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326426001160 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326426001161 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 326426001162 oligomeric interface; other site 326426001163 putative active site [active] 326426001164 homodimer interface [polypeptide binding]; other site 326426001165 Plasmid stability protein [General function prediction only]; Region: StbC; COG4691 326426001166 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 326426001167 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 326426001168 putative valine binding site [chemical binding]; other site 326426001169 dimer interface [polypeptide binding]; other site 326426001170 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 326426001171 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 326426001172 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 326426001173 PYR/PP interface [polypeptide binding]; other site 326426001174 dimer interface [polypeptide binding]; other site 326426001175 TPP binding site [chemical binding]; other site 326426001176 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 326426001177 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 326426001178 TPP-binding site [chemical binding]; other site 326426001179 dimer interface [polypeptide binding]; other site 326426001180 ribonuclease III; Reviewed; Region: rnc; PRK00102 326426001181 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 326426001182 dimerization interface [polypeptide binding]; other site 326426001183 active site 326426001184 metal binding site [ion binding]; metal-binding site 326426001185 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 326426001186 dsRNA binding site [nucleotide binding]; other site 326426001187 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 326426001188 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 326426001189 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 326426001190 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 326426001191 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 326426001192 active site 326426001193 (T/H)XGH motif; other site 326426001194 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 326426001195 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326426001196 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326426001197 active site 326426001198 catalytic tetrad [active] 326426001199 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326426001200 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 326426001201 DNA binding residues [nucleotide binding] 326426001202 putative dimer interface [polypeptide binding]; other site 326426001203 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 326426001204 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 326426001205 active site 326426001206 ribonuclease PH; Reviewed; Region: rph; PRK00173 326426001207 Ribonuclease PH; Region: RNase_PH_bact; cd11362 326426001208 hexamer interface [polypeptide binding]; other site 326426001209 active site 326426001210 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 326426001211 active site 326426001212 dimerization interface [polypeptide binding]; other site 326426001213 Membrane transport protein; Region: Mem_trans; cl09117 326426001214 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 326426001215 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 326426001216 active site 326426001217 dimer interface [polypeptide binding]; other site 326426001218 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 326426001219 dimer interface [polypeptide binding]; other site 326426001220 active site 326426001221 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 326426001222 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 326426001223 Walker A/P-loop; other site 326426001224 ATP binding site [chemical binding]; other site 326426001225 Q-loop/lid; other site 326426001226 ABC transporter signature motif; other site 326426001227 Walker B; other site 326426001228 D-loop; other site 326426001229 H-loop/switch region; other site 326426001230 ABC nitrate/sulfonate/bicarbonate family transporter, ATPase subunit; Region: ABC_transp; pfam09821 326426001231 ABC-type anion transport system, duplicated permease component [Inorganic ion transport and metabolism]; Region: COG4986 326426001232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001233 dimer interface [polypeptide binding]; other site 326426001234 conserved gate region; other site 326426001235 putative PBP binding loops; other site 326426001236 ABC-ATPase subunit interface; other site 326426001237 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001238 dimer interface [polypeptide binding]; other site 326426001239 conserved gate region; other site 326426001240 putative PBP binding loops; other site 326426001241 ABC-ATPase subunit interface; other site 326426001242 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 326426001243 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 326426001244 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 326426001245 Catalytic site [active] 326426001246 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 326426001247 RNA/DNA hybrid binding site [nucleotide binding]; other site 326426001248 active site 326426001249 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426001250 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426001251 DNA binding site [nucleotide binding] 326426001252 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 326426001253 ligand binding site [chemical binding]; other site 326426001254 dimerization interface (open form) [polypeptide binding]; other site 326426001255 dimerization interface (closed form) [polypeptide binding]; other site 326426001256 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 326426001257 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 326426001258 acyl-activating enzyme (AAE) consensus motif; other site 326426001259 putative AMP binding site [chemical binding]; other site 326426001260 putative active site [active] 326426001261 putative CoA binding site [chemical binding]; other site 326426001262 K+-dependent Na+/Ca+ exchanger; Region: 2A1904; TIGR00927 326426001263 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 326426001264 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326426001265 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426001266 Walker A/P-loop; other site 326426001267 ATP binding site [chemical binding]; other site 326426001268 Q-loop/lid; other site 326426001269 ABC transporter signature motif; other site 326426001270 Walker B; other site 326426001271 D-loop; other site 326426001272 H-loop/switch region; other site 326426001273 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326426001274 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326426001275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426001276 Walker A/P-loop; other site 326426001277 ATP binding site [chemical binding]; other site 326426001278 Q-loop/lid; other site 326426001279 ABC transporter signature motif; other site 326426001280 Walker B; other site 326426001281 D-loop; other site 326426001282 H-loop/switch region; other site 326426001283 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426001284 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426001285 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001286 dimer interface [polypeptide binding]; other site 326426001287 conserved gate region; other site 326426001288 putative PBP binding loops; other site 326426001289 ABC-ATPase subunit interface; other site 326426001290 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426001291 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001292 dimer interface [polypeptide binding]; other site 326426001293 conserved gate region; other site 326426001294 putative PBP binding loops; other site 326426001295 ABC-ATPase subunit interface; other site 326426001296 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 326426001297 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 326426001298 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 326426001299 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 326426001300 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426001301 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426001302 DNA binding site [nucleotide binding] 326426001303 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426001304 ligand binding site [chemical binding]; other site 326426001305 dimerization interface [polypeptide binding]; other site 326426001306 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; pfam07745 326426001307 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 326426001308 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 326426001309 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326426001310 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326426001311 active site 326426001312 catalytic tetrad [active] 326426001313 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 326426001314 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 326426001315 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 326426001316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426001317 putative substrate translocation pore; other site 326426001318 D-galactonate transporter; Region: 2A0114; TIGR00893 326426001319 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426001320 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 326426001321 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 326426001322 Bacterial sugar transferase; Region: Bac_transf; pfam02397 326426001323 Low molecular weight phosphatase family; Region: LMWPc; cd00115 326426001324 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 326426001325 active site 326426001326 transposase/IS protein; Provisional; Region: PRK09183 326426001327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426001328 Walker A motif; other site 326426001329 ATP binding site [chemical binding]; other site 326426001330 Walker B motif; other site 326426001331 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426001332 Integrase core domain; Region: rve; pfam00665 326426001333 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 326426001334 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 326426001335 Core-2/I-Branching enzyme; Region: Branch; pfam02485 326426001336 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 326426001337 trimer interface [polypeptide binding]; other site 326426001338 active site 326426001339 substrate binding site [chemical binding]; other site 326426001340 CoA binding site [chemical binding]; other site 326426001341 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326426001342 active site 326426001343 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 326426001344 Flagellin N-methylase; Region: FliB; cl00497 326426001345 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 326426001346 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 326426001347 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326426001348 putative ADP-binding pocket [chemical binding]; other site 326426001349 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 326426001350 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326426001351 putative ADP-binding pocket [chemical binding]; other site 326426001352 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326426001353 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326426001354 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 326426001355 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 326426001356 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326426001357 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326426001358 active site 326426001359 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 326426001360 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 326426001361 active site 326426001362 substrate binding site [chemical binding]; other site 326426001363 trimer interface [polypeptide binding]; other site 326426001364 CoA binding site [chemical binding]; other site 326426001365 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 326426001366 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326426001367 active site 326426001368 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 326426001369 Acyltransferase family; Region: Acyl_transf_3; pfam01757 326426001370 transposase; Provisional; Region: PRK06526 326426001371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426001372 Walker A motif; other site 326426001373 ATP binding site [chemical binding]; other site 326426001374 Walker B motif; other site 326426001375 transposase/IS protein; Provisional; Region: PRK09183 326426001376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426001377 Walker A motif; other site 326426001378 ATP binding site [chemical binding]; other site 326426001379 Walker B motif; other site 326426001380 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426001381 Integrase core domain; Region: rve; pfam00665 326426001382 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426001383 Integrase core domain; Region: rve; pfam00665 326426001384 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 326426001385 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 326426001386 transposase/IS protein; Provisional; Region: PRK09183 326426001387 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426001388 Walker A motif; other site 326426001389 ATP binding site [chemical binding]; other site 326426001390 Walker B motif; other site 326426001391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426001392 Integrase core domain; Region: rve; pfam00665 326426001393 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 326426001394 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 326426001395 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326426001396 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326426001397 non-specific DNA binding site [nucleotide binding]; other site 326426001398 salt bridge; other site 326426001399 sequence-specific DNA binding site [nucleotide binding]; other site 326426001400 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 326426001401 Chain length determinant protein; Region: Wzz; cl15801 326426001402 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 326426001403 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 326426001404 Nucleotide binding site [chemical binding]; other site 326426001405 DTAP/Switch II; other site 326426001406 Switch I; other site 326426001407 Domain of unknown function (DUF348); Region: DUF348; pfam03990 326426001408 G5 domain; Region: G5; pfam07501 326426001409 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326426001410 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326426001411 catalytic residue [active] 326426001412 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 326426001413 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326426001414 catalytic residues [active] 326426001415 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 326426001416 nudix motif; other site 326426001417 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326426001418 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 326426001419 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 326426001420 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 326426001421 putative NADH binding site [chemical binding]; other site 326426001422 putative active site [active] 326426001423 nudix motif; other site 326426001424 putative metal binding site [ion binding]; other site 326426001425 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 326426001426 lipoyl attachment site [posttranslational modification]; other site 326426001427 Uncharacterized conserved protein [Function unknown]; Region: COG4850 326426001428 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 326426001429 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 326426001430 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 326426001431 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 326426001432 tartrate dehydrogenase; Region: TTC; TIGR02089 326426001433 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 326426001434 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 326426001435 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 326426001436 ligand binding site [chemical binding]; other site 326426001437 flexible hinge region; other site 326426001438 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 326426001439 putative switch regulator; other site 326426001440 non-specific DNA interactions [nucleotide binding]; other site 326426001441 DNA binding site [nucleotide binding] 326426001442 sequence specific DNA binding site [nucleotide binding]; other site 326426001443 putative cAMP binding site [chemical binding]; other site 326426001444 Transglycosylase; Region: Transgly; pfam00912 326426001445 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 326426001446 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 326426001447 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 326426001448 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 326426001449 active site 326426001450 FMN binding site [chemical binding]; other site 326426001451 substrate binding site [chemical binding]; other site 326426001452 homotetramer interface [polypeptide binding]; other site 326426001453 catalytic residue [active] 326426001454 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 326426001455 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 326426001456 quinone interaction residues [chemical binding]; other site 326426001457 active site 326426001458 catalytic residues [active] 326426001459 FMN binding site [chemical binding]; other site 326426001460 substrate binding site [chemical binding]; other site 326426001461 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 326426001462 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 326426001463 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 326426001464 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 326426001465 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 326426001466 dimer interface [polypeptide binding]; other site 326426001467 active site 326426001468 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 326426001469 galactokinase; Provisional; Region: PRK05322 326426001470 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 326426001471 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 326426001472 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 326426001473 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 326426001474 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 326426001475 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 326426001476 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326426001477 minor groove reading motif; other site 326426001478 helix-hairpin-helix signature motif; other site 326426001479 active site 326426001480 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 326426001481 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 326426001482 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 326426001483 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 326426001484 RPB1 interaction site [polypeptide binding]; other site 326426001485 RPB10 interaction site [polypeptide binding]; other site 326426001486 RPB11 interaction site [polypeptide binding]; other site 326426001487 RPB3 interaction site [polypeptide binding]; other site 326426001488 RPB12 interaction site [polypeptide binding]; other site 326426001489 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 326426001490 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 326426001491 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 326426001492 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 326426001493 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 326426001494 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 326426001495 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 326426001496 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 326426001497 DNA binding site [nucleotide binding] 326426001498 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 326426001499 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 326426001500 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 326426001501 Protein of unknown function DUF58; Region: DUF58; pfam01882 326426001502 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326426001503 Interdomain contacts; other site 326426001504 Cytokine receptor motif; other site 326426001505 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 326426001506 Interdomain contacts; other site 326426001507 Cytokine receptor motif; other site 326426001508 MoxR-like ATPases [General function prediction only]; Region: COG0714 326426001509 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426001510 Walker A motif; other site 326426001511 ATP binding site [chemical binding]; other site 326426001512 Walker B motif; other site 326426001513 arginine finger; other site 326426001514 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326426001515 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326426001516 active site 326426001517 ATP binding site [chemical binding]; other site 326426001518 substrate binding site [chemical binding]; other site 326426001519 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 326426001520 substrate binding site [chemical binding]; other site 326426001521 activation loop (A-loop); other site 326426001522 activation loop (A-loop); other site 326426001523 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326426001524 Part of AAA domain; Region: AAA_19; pfam13245 326426001525 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326426001526 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 326426001527 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426001528 putative substrate translocation pore; other site 326426001529 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326426001530 dihydrodipicolinate reductase; Provisional; Region: PRK00048 326426001531 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 326426001532 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 326426001533 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 326426001534 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 326426001535 dimer interface [polypeptide binding]; other site 326426001536 active site 326426001537 catalytic residue [active] 326426001538 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 326426001539 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 326426001540 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 326426001541 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 326426001542 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 326426001543 Zn binding site [ion binding]; other site 326426001544 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 326426001545 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 326426001546 active site 326426001547 substrate binding site [chemical binding]; other site 326426001548 metal binding site [ion binding]; metal-binding site 326426001549 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 326426001550 active site 326426001551 catalytic residues [active] 326426001552 metal binding site [ion binding]; metal-binding site 326426001553 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 326426001554 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 326426001555 active site 326426001556 catalytic site [active] 326426001557 substrate binding site [chemical binding]; other site 326426001558 peptide chain release factor 2; Validated; Region: prfB; PRK00578 326426001559 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 326426001560 This domain is found in peptide chain release factors; Region: PCRF; smart00937 326426001561 RF-1 domain; Region: RF-1; pfam00472 326426001562 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 326426001563 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426001564 Walker A/P-loop; other site 326426001565 ATP binding site [chemical binding]; other site 326426001566 Q-loop/lid; other site 326426001567 ABC transporter signature motif; other site 326426001568 Walker B; other site 326426001569 D-loop; other site 326426001570 H-loop/switch region; other site 326426001571 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 326426001572 FtsX-like permease family; Region: FtsX; pfam02687 326426001573 CHAP domain; Region: CHAP; pfam05257 326426001574 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 326426001575 SmpB-tmRNA interface; other site 326426001576 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326426001577 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326426001578 substrate binding pocket [chemical binding]; other site 326426001579 membrane-bound complex binding site; other site 326426001580 hinge residues; other site 326426001581 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326426001582 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326426001583 substrate binding pocket [chemical binding]; other site 326426001584 membrane-bound complex binding site; other site 326426001585 hinge residues; other site 326426001586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001587 dimer interface [polypeptide binding]; other site 326426001588 conserved gate region; other site 326426001589 putative PBP binding loops; other site 326426001590 ABC-ATPase subunit interface; other site 326426001591 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326426001592 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326426001593 Walker A/P-loop; other site 326426001594 ATP binding site [chemical binding]; other site 326426001595 Q-loop/lid; other site 326426001596 ABC transporter signature motif; other site 326426001597 Walker B; other site 326426001598 D-loop; other site 326426001599 H-loop/switch region; other site 326426001600 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 326426001601 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 326426001602 glutaminase active site [active] 326426001603 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 326426001604 dimer interface [polypeptide binding]; other site 326426001605 active site 326426001606 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 326426001607 dimer interface [polypeptide binding]; other site 326426001608 active site 326426001609 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 326426001610 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 326426001611 active site 326426001612 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426001613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426001614 DNA binding site [nucleotide binding] 326426001615 domain linker motif; other site 326426001616 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 326426001617 ligand binding site [chemical binding]; other site 326426001618 dimerization interface (open form) [polypeptide binding]; other site 326426001619 dimerization interface (closed form) [polypeptide binding]; other site 326426001620 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001621 dimer interface [polypeptide binding]; other site 326426001622 conserved gate region; other site 326426001623 putative PBP binding loops; other site 326426001624 ABC-ATPase subunit interface; other site 326426001625 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426001626 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001627 dimer interface [polypeptide binding]; other site 326426001628 conserved gate region; other site 326426001629 putative PBP binding loops; other site 326426001630 ABC-ATPase subunit interface; other site 326426001631 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 326426001632 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 326426001633 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 326426001634 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 326426001635 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426001636 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426001637 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326426001638 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426001639 pantothenate kinase; Reviewed; Region: PRK13318 326426001640 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 326426001641 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 326426001642 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326426001643 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 326426001644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001645 ABC-ATPase subunit interface; other site 326426001646 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326426001647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426001648 ABC-ATPase subunit interface; other site 326426001649 putative PBP binding loops; other site 326426001650 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326426001651 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326426001652 Walker A/P-loop; other site 326426001653 ATP binding site [chemical binding]; other site 326426001654 Q-loop/lid; other site 326426001655 ABC transporter signature motif; other site 326426001656 Walker B; other site 326426001657 D-loop; other site 326426001658 H-loop/switch region; other site 326426001659 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 326426001660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326426001661 Walker A/P-loop; other site 326426001662 ATP binding site [chemical binding]; other site 326426001663 Q-loop/lid; other site 326426001664 ABC transporter signature motif; other site 326426001665 Walker B; other site 326426001666 D-loop; other site 326426001667 H-loop/switch region; other site 326426001668 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 326426001669 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 326426001670 dimer interface [polypeptide binding]; other site 326426001671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426001672 catalytic residue [active] 326426001673 cystathionine gamma-synthase; Provisional; Region: PRK07811 326426001674 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326426001675 homodimer interface [polypeptide binding]; other site 326426001676 substrate-cofactor binding pocket; other site 326426001677 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426001678 catalytic residue [active] 326426001679 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 326426001680 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426001681 ATP binding site [chemical binding]; other site 326426001682 putative Mg++ binding site [ion binding]; other site 326426001683 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426001684 nucleotide binding region [chemical binding]; other site 326426001685 ATP-binding site [chemical binding]; other site 326426001686 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 326426001687 HRDC domain; Region: HRDC; pfam00570 326426001688 S-ribosylhomocysteinase; Provisional; Region: PRK02260 326426001689 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 326426001690 amino acid transporter; Region: 2A0306; TIGR00909 326426001691 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 326426001692 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 326426001693 alanine racemase; Reviewed; Region: alr; PRK00053 326426001694 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 326426001695 active site 326426001696 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326426001697 dimer interface [polypeptide binding]; other site 326426001698 substrate binding site [chemical binding]; other site 326426001699 catalytic residues [active] 326426001700 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 326426001701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326426001702 Zn2+ binding site [ion binding]; other site 326426001703 Mg2+ binding site [ion binding]; other site 326426001704 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 326426001705 DNA primase, catalytic core; Region: dnaG; TIGR01391 326426001706 CHC2 zinc finger; Region: zf-CHC2; cl17510 326426001707 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 326426001708 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 326426001709 active site 326426001710 metal binding site [ion binding]; metal-binding site 326426001711 interdomain interaction site; other site 326426001712 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 326426001713 PIN domain; Region: PIN_3; pfam13470 326426001714 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 326426001715 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 326426001716 active site 326426001717 multimer interface [polypeptide binding]; other site 326426001718 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13152 326426001719 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 326426001720 predicted active site [active] 326426001721 catalytic triad [active] 326426001722 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326426001723 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326426001724 DNA-binding site [nucleotide binding]; DNA binding site 326426001725 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426001726 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426001727 homodimer interface [polypeptide binding]; other site 326426001728 catalytic residue [active] 326426001729 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 326426001730 transmembrane helices; other site 326426001731 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 326426001732 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 326426001733 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 326426001734 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 326426001735 putative active site [active] 326426001736 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426001737 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426001738 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426001739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426001740 DNA binding site [nucleotide binding] 326426001741 domain linker motif; other site 326426001742 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426001743 ligand binding site [chemical binding]; other site 326426001744 dimerization interface [polypeptide binding]; other site 326426001745 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 326426001746 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 326426001747 Ca binding site [ion binding]; other site 326426001748 active site 326426001749 catalytic site [active] 326426001750 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 326426001751 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 326426001752 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 326426001753 Peptide methionine sulfoxide reductase; Region: PMSR; cl00366 326426001754 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426001755 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426001756 Walker A/P-loop; other site 326426001757 ATP binding site [chemical binding]; other site 326426001758 Q-loop/lid; other site 326426001759 ABC transporter signature motif; other site 326426001760 Walker B; other site 326426001761 D-loop; other site 326426001762 H-loop/switch region; other site 326426001763 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 326426001764 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426001765 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326426001766 FtsX-like permease family; Region: FtsX; pfam02687 326426001767 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315 326426001768 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 326426001769 TPP-binding site; other site 326426001770 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 326426001771 PYR/PP interface [polypeptide binding]; other site 326426001772 dimer interface [polypeptide binding]; other site 326426001773 TPP binding site [chemical binding]; other site 326426001774 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326426001775 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 326426001776 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 326426001777 NAD(P) binding site [chemical binding]; other site 326426001778 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 326426001779 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 326426001780 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 326426001781 NAD binding site [chemical binding]; other site 326426001782 ATP-grasp domain; Region: ATP-grasp; pfam02222 326426001783 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 326426001784 metal binding site 2 [ion binding]; metal-binding site 326426001785 putative DNA binding helix; other site 326426001786 metal binding site 1 [ion binding]; metal-binding site 326426001787 dimer interface [polypeptide binding]; other site 326426001788 structural Zn2+ binding site [ion binding]; other site 326426001789 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 326426001790 metal binding site 2 [ion binding]; metal-binding site 326426001791 putative DNA binding helix; other site 326426001792 metal binding site 1 [ion binding]; metal-binding site 326426001793 dimer interface [polypeptide binding]; other site 326426001794 structural Zn2+ binding site [ion binding]; other site 326426001795 TIGR03943 family protein; Region: TIGR03943 326426001796 Predicted permease; Region: DUF318; cl17795 326426001797 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 326426001798 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 326426001799 metal binding site [ion binding]; metal-binding site 326426001800 Sulfatase; Region: Sulfatase; pfam00884 326426001801 ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087 326426001802 aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381 326426001803 NAD(P) binding site [chemical binding]; other site 326426001804 catalytic residues [active] 326426001805 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 326426001806 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 326426001807 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 326426001808 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 326426001809 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 326426001810 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 326426001811 dimerization interface [polypeptide binding]; other site 326426001812 putative ATP binding site [chemical binding]; other site 326426001813 amidophosphoribosyltransferase; Provisional; Region: PRK07272 326426001814 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 326426001815 active site 326426001816 tetramer interface [polypeptide binding]; other site 326426001817 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326426001818 active site 326426001819 DNA polymerase IV; Reviewed; Region: PRK03103 326426001820 Y-family of DNA polymerases; Region: PolY; cl12025 326426001821 active site 326426001822 DNA binding site [nucleotide binding] 326426001823 MUG-like Uracil-DNA glycosylase enzyme family; Region: UDG_MUG_like; cd10032 326426001824 putative active site [active] 326426001825 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 326426001826 Yqey-like protein; Region: YqeY; cl17540 326426001827 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 326426001828 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 326426001829 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 326426001830 dimerization interface [polypeptide binding]; other site 326426001831 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 326426001832 dimerization interface [polypeptide binding]; other site 326426001833 ATP binding site [chemical binding]; other site 326426001834 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 326426001835 dimerization interface [polypeptide binding]; other site 326426001836 ATP binding site [chemical binding]; other site 326426001837 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 326426001838 putative active site [active] 326426001839 catalytic triad [active] 326426001840 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 326426001841 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 326426001842 ATP binding site [chemical binding]; other site 326426001843 active site 326426001844 substrate binding site [chemical binding]; other site 326426001845 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 326426001846 ATP-grasp domain; Region: ATP-grasp; pfam02222 326426001847 LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276 326426001848 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426001849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426001850 homodimer interface [polypeptide binding]; other site 326426001851 catalytic residue [active] 326426001852 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 326426001853 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326426001854 putative ADP-binding pocket [chemical binding]; other site 326426001855 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 326426001856 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 326426001857 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326426001858 catalytic residue [active] 326426001859 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 326426001860 Sodium Bile acid symporter family; Region: SBF; pfam01758 326426001861 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 326426001862 S17 interaction site [polypeptide binding]; other site 326426001863 S8 interaction site; other site 326426001864 16S rRNA interaction site [nucleotide binding]; other site 326426001865 streptomycin interaction site [chemical binding]; other site 326426001866 23S rRNA interaction site [nucleotide binding]; other site 326426001867 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 326426001868 30S ribosomal protein S7; Validated; Region: PRK05302 326426001869 elongation factor G; Reviewed; Region: PRK00007 326426001870 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 326426001871 G1 box; other site 326426001872 putative GEF interaction site [polypeptide binding]; other site 326426001873 GTP/Mg2+ binding site [chemical binding]; other site 326426001874 Switch I region; other site 326426001875 G2 box; other site 326426001876 G3 box; other site 326426001877 Switch II region; other site 326426001878 G4 box; other site 326426001879 G5 box; other site 326426001880 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 326426001881 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 326426001882 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 326426001883 elongation factor Tu; Reviewed; Region: PRK00049 326426001884 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 326426001885 G1 box; other site 326426001886 GEF interaction site [polypeptide binding]; other site 326426001887 GTP/Mg2+ binding site [chemical binding]; other site 326426001888 Switch I region; other site 326426001889 G2 box; other site 326426001890 G3 box; other site 326426001891 Switch II region; other site 326426001892 G4 box; other site 326426001893 G5 box; other site 326426001894 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 326426001895 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 326426001896 Antibiotic Binding Site [chemical binding]; other site 326426001897 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 326426001898 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326426001899 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326426001900 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 326426001901 dimerization interface [polypeptide binding]; other site 326426001902 Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075 326426001903 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 326426001904 CrcB-like protein; Region: CRCB; pfam02537 326426001905 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 326426001906 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326426001907 DNA binding residues [nucleotide binding] 326426001908 putative dimer interface [polypeptide binding]; other site 326426001909 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 326426001910 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 326426001911 catalytic Zn binding site [ion binding]; other site 326426001912 NAD(P) binding site [chemical binding]; other site 326426001913 structural Zn binding site [ion binding]; other site 326426001914 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 326426001915 AAA domain; Region: AAA_14; pfam13173 326426001916 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 326426001917 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426001918 Walker A/P-loop; other site 326426001919 ATP binding site [chemical binding]; other site 326426001920 Q-loop/lid; other site 326426001921 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 326426001922 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426001923 ABC transporter signature motif; other site 326426001924 Walker B; other site 326426001925 D-loop; other site 326426001926 H-loop/switch region; other site 326426001927 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426001928 Walker A/P-loop; other site 326426001929 ATP binding site [chemical binding]; other site 326426001930 Q-loop/lid; other site 326426001931 ABC transporter signature motif; other site 326426001932 Walker B; other site 326426001933 D-loop; other site 326426001934 H-loop/switch region; other site 326426001935 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 326426001936 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 326426001937 Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231 326426001938 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 326426001939 minor groove reading motif; other site 326426001940 helix-hairpin-helix signature motif; other site 326426001941 substrate binding pocket [chemical binding]; other site 326426001942 active site 326426001943 maltose O-acetyltransferase; Provisional; Region: PRK10092 326426001944 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 326426001945 active site 326426001946 substrate binding site [chemical binding]; other site 326426001947 trimer interface [polypeptide binding]; other site 326426001948 CoA binding site [chemical binding]; other site 326426001949 Predicted permeases [General function prediction only]; Region: COG0679 326426001950 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 326426001951 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 326426001952 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 326426001953 active site 326426001954 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 326426001955 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 326426001956 metal binding site [ion binding]; metal-binding site 326426001957 active site 326426001958 I-site; other site 326426001959 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 326426001960 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 326426001961 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426001962 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426001963 Walker A/P-loop; other site 326426001964 ATP binding site [chemical binding]; other site 326426001965 Q-loop/lid; other site 326426001966 ABC transporter signature motif; other site 326426001967 Walker B; other site 326426001968 D-loop; other site 326426001969 H-loop/switch region; other site 326426001970 elongation factor P; Validated; Region: PRK00529 326426001971 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 326426001972 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 326426001973 RNA binding site [nucleotide binding]; other site 326426001974 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 326426001975 RNA binding site [nucleotide binding]; other site 326426001976 transcription antitermination factor NusB; Region: nusB; TIGR01951 326426001977 putative RNA binding site [nucleotide binding]; other site 326426001978 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 326426001979 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 326426001980 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 326426001981 catalytic site [active] 326426001982 subunit interface [polypeptide binding]; other site 326426001983 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 326426001984 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326426001985 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326426001986 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 326426001987 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326426001988 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326426001989 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 326426001990 IMP binding site; other site 326426001991 dimer interface [polypeptide binding]; other site 326426001992 interdomain contacts; other site 326426001993 partial ornithine binding site; other site 326426001994 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 326426001995 active site 326426001996 dimer interface [polypeptide binding]; other site 326426001997 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 326426001998 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 326426001999 catalytic site [active] 326426002000 G-X2-G-X-G-K; other site 326426002001 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 326426002002 active site 326426002003 catalytic site [active] 326426002004 substrate binding site [chemical binding]; other site 326426002005 large tegument protein UL36; Provisional; Region: PHA03247 326426002006 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 326426002007 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 326426002008 G1 box; other site 326426002009 putative GEF interaction site [polypeptide binding]; other site 326426002010 GTP/Mg2+ binding site [chemical binding]; other site 326426002011 Switch I region; other site 326426002012 G2 box; other site 326426002013 G3 box; other site 326426002014 Switch II region; other site 326426002015 G4 box; other site 326426002016 G5 box; other site 326426002017 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 326426002018 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 326426002019 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 326426002020 Predicted esterase [General function prediction only]; Region: COG0400 326426002021 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 326426002022 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326426002023 homodimer interface [polypeptide binding]; other site 326426002024 substrate-cofactor binding pocket; other site 326426002025 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426002026 catalytic residue [active] 326426002027 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 326426002028 catalytic residues [active] 326426002029 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 326426002030 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 326426002031 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 326426002032 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 326426002033 active site 326426002034 nucleophile elbow; other site 326426002035 glutamate racemase; Provisional; Region: PRK00865 326426002036 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 326426002037 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 326426002038 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 326426002039 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 326426002040 putative active site [active] 326426002041 redox center [active] 326426002042 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 326426002043 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 326426002044 active site 326426002045 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 326426002046 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 326426002047 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326426002048 substrate binding site [chemical binding]; other site 326426002049 Merozoite surface protein 1 (MSP1) C-terminus; Region: MSP1_C; pfam07462 326426002050 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 326426002051 Part of AAA domain; Region: AAA_19; pfam13245 326426002052 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326426002053 Family description; Region: UvrD_C_2; pfam13538 326426002054 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 326426002055 Uncharacterized conserved protein (DUF2342); Region: DUF2342; cl02183 326426002056 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 326426002057 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 326426002058 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 326426002059 DivIVA domain; Region: DivI1A_domain; TIGR03544 326426002060 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 326426002061 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 326426002062 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 326426002063 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 326426002064 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 326426002065 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 326426002066 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 326426002067 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326426002068 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 326426002069 Recombination protein O N terminal; Region: RecO_N; pfam11967 326426002070 Recombination protein O C terminal; Region: RecO_C; pfam02565 326426002071 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 326426002072 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 326426002073 catalytic residue [active] 326426002074 putative FPP diphosphate binding site; other site 326426002075 putative FPP binding hydrophobic cleft; other site 326426002076 dimer interface [polypeptide binding]; other site 326426002077 putative IPP diphosphate binding site; other site 326426002078 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 326426002079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426002080 dimer interface [polypeptide binding]; other site 326426002081 conserved gate region; other site 326426002082 putative PBP binding loops; other site 326426002083 ABC-ATPase subunit interface; other site 326426002084 NMT1/THI5 like; Region: NMT1; pfam09084 326426002085 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426002086 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 326426002087 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426002088 homodimer interface [polypeptide binding]; other site 326426002089 catalytic residue [active] 326426002090 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326426002091 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426002092 Walker A/P-loop; other site 326426002093 ATP binding site [chemical binding]; other site 326426002094 ABC transporter signature motif; other site 326426002095 Walker B; other site 326426002096 D-loop; other site 326426002097 H-loop/switch region; other site 326426002098 Ligase N family; Region: LIGANc; smart00532 326426002099 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 326426002100 nucleotide binding pocket [chemical binding]; other site 326426002101 K-X-D-G motif; other site 326426002102 catalytic site [active] 326426002103 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 326426002104 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 326426002105 Helix-hairpin-helix motif; Region: HHH; pfam00633 326426002106 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 326426002107 Dimer interface [polypeptide binding]; other site 326426002108 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 326426002109 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 326426002110 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 326426002111 Walker A motif; other site 326426002112 glutamine synthetase, type I; Region: GlnA; TIGR00653 326426002113 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 326426002114 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326426002115 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 326426002116 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 326426002117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326426002118 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326426002119 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326426002120 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 326426002121 hypothetical protein; Provisional; Region: PRK07907 326426002122 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 326426002123 active site 326426002124 metal binding site [ion binding]; metal-binding site 326426002125 dimer interface [polypeptide binding]; other site 326426002126 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 326426002127 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326426002128 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 326426002129 Walker A/P-loop; other site 326426002130 ATP binding site [chemical binding]; other site 326426002131 Q-loop/lid; other site 326426002132 ABC transporter signature motif; other site 326426002133 Walker B; other site 326426002134 D-loop; other site 326426002135 H-loop/switch region; other site 326426002136 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326426002137 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326426002138 Walker A/P-loop; other site 326426002139 ATP binding site [chemical binding]; other site 326426002140 Q-loop/lid; other site 326426002141 ABC transporter signature motif; other site 326426002142 Walker B; other site 326426002143 D-loop; other site 326426002144 H-loop/switch region; other site 326426002145 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 326426002146 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 326426002147 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 326426002148 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 326426002149 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 326426002150 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 326426002151 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 326426002152 dimer interface [polypeptide binding]; other site 326426002153 motif 1; other site 326426002154 active site 326426002155 motif 2; other site 326426002156 motif 3; other site 326426002157 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 326426002158 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 326426002159 putative tRNA-binding site [nucleotide binding]; other site 326426002160 B3/4 domain; Region: B3_4; pfam03483 326426002161 tRNA synthetase B5 domain; Region: B5; pfam03484 326426002162 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 326426002163 dimer interface [polypeptide binding]; other site 326426002164 motif 1; other site 326426002165 motif 3; other site 326426002166 motif 2; other site 326426002167 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 326426002168 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 326426002169 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 326426002170 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 326426002171 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 326426002172 heterotetramer interface [polypeptide binding]; other site 326426002173 active site pocket [active] 326426002174 cleavage site 326426002175 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 326426002176 feedback inhibition sensing region; other site 326426002177 homohexameric interface [polypeptide binding]; other site 326426002178 nucleotide binding site [chemical binding]; other site 326426002179 N-acetyl-L-glutamate binding site [chemical binding]; other site 326426002180 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 326426002181 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 326426002182 inhibitor-cofactor binding pocket; inhibition site 326426002183 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426002184 catalytic residue [active] 326426002185 ornithine carbamoyltransferase; Provisional; Region: PRK00779 326426002186 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 326426002187 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 326426002188 arginine repressor; Provisional; Region: PRK03341 326426002189 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 326426002190 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 326426002191 argininosuccinate synthase; Provisional; Region: PRK13820 326426002192 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 326426002193 ANP binding site [chemical binding]; other site 326426002194 Substrate Binding Site II [chemical binding]; other site 326426002195 Substrate Binding Site I [chemical binding]; other site 326426002196 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426002197 Integrase core domain; Region: rve; pfam00665 326426002198 transposase/IS protein; Provisional; Region: PRK09183 326426002199 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426002200 Walker A motif; other site 326426002201 ATP binding site [chemical binding]; other site 326426002202 Walker B motif; other site 326426002203 argininosuccinate lyase; Provisional; Region: PRK00855 326426002204 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 326426002205 active sites [active] 326426002206 tetramer interface [polypeptide binding]; other site 326426002207 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 326426002208 thiS-thiF/thiG interaction site; other site 326426002209 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 326426002210 ThiS interaction site; other site 326426002211 putative active site [active] 326426002212 tetramer interface [polypeptide binding]; other site 326426002213 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 326426002214 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 326426002215 ATP binding site [chemical binding]; other site 326426002216 substrate interface [chemical binding]; other site 326426002217 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 326426002218 active site residue [active] 326426002219 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326426002220 Zn2+ binding site [ion binding]; other site 326426002221 Mg2+ binding site [ion binding]; other site 326426002222 Predicted membrane protein [Function unknown]; Region: COG4905 326426002223 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 326426002224 Protein of unknown function (DUF975); Region: DUF975; cl10504 326426002225 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 326426002226 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 326426002227 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 326426002228 active site 326426002229 HIGH motif; other site 326426002230 dimer interface [polypeptide binding]; other site 326426002231 KMSKS motif; other site 326426002232 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326426002233 RNA binding surface [nucleotide binding]; other site 326426002234 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 326426002235 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 326426002236 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426002237 active site 326426002238 motif I; other site 326426002239 motif II; other site 326426002240 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426002241 motif II; other site 326426002242 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 326426002243 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326426002244 RNA binding surface [nucleotide binding]; other site 326426002245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426002246 S-adenosylmethionine binding site [chemical binding]; other site 326426002247 Protein of unknown function (DUF342); Region: DUF342; pfam03961 326426002248 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 326426002249 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 326426002250 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 326426002251 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 326426002252 Walker A/P-loop; other site 326426002253 ATP binding site [chemical binding]; other site 326426002254 Q-loop/lid; other site 326426002255 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 326426002256 ABC transporter signature motif; other site 326426002257 Walker B; other site 326426002258 D-loop; other site 326426002259 H-loop/switch region; other site 326426002260 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 326426002261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426002262 motif II; other site 326426002263 Predicted transcriptional regulators [Transcription]; Region: COG1725 326426002264 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326426002265 DNA-binding site [nucleotide binding]; DNA binding site 326426002266 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326426002267 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326426002268 Walker A/P-loop; other site 326426002269 ATP binding site [chemical binding]; other site 326426002270 Q-loop/lid; other site 326426002271 ABC transporter signature motif; other site 326426002272 Walker B; other site 326426002273 D-loop; other site 326426002274 H-loop/switch region; other site 326426002275 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 326426002276 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 326426002277 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 326426002278 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426002279 catalytic residue [active] 326426002280 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 326426002281 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 326426002282 putative catalytic cysteine [active] 326426002283 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 326426002284 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 326426002285 active site 326426002286 (T/H)XGH motif; other site 326426002287 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 326426002288 Uncharacterized conserved protein [Function unknown]; Region: COG1615 326426002289 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326426002290 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326426002291 Coenzyme A binding pocket [chemical binding]; other site 326426002292 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 326426002293 putative active site [active] 326426002294 catalytic residue [active] 326426002295 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 326426002296 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 326426002297 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426002298 ATP binding site [chemical binding]; other site 326426002299 putative Mg++ binding site [ion binding]; other site 326426002300 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426002301 nucleotide binding region [chemical binding]; other site 326426002302 ATP-binding site [chemical binding]; other site 326426002303 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 326426002304 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326426002305 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326426002306 active site 326426002307 catalytic tetrad [active] 326426002308 enolase; Provisional; Region: eno; PRK00077 326426002309 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 326426002310 dimer interface [polypeptide binding]; other site 326426002311 metal binding site [ion binding]; metal-binding site 326426002312 substrate binding pocket [chemical binding]; other site 326426002313 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 326426002314 Septum formation initiator; Region: DivIC; pfam04977 326426002315 Protein of unknown function (DUF501); Region: DUF501; pfam04417 326426002316 exopolyphosphatase; Region: exo_poly_only; TIGR03706 326426002317 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 326426002318 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 326426002319 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 326426002320 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 326426002321 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 326426002322 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 326426002323 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 326426002324 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 326426002325 Haemolysin-III related; Region: HlyIII; pfam03006 326426002326 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 326426002327 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 326426002328 PAS fold; Region: PAS_4; pfam08448 326426002329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 326426002330 Histidine kinase; Region: HisKA_2; pfam07568 326426002331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426002332 ATP binding site [chemical binding]; other site 326426002333 Mg2+ binding site [ion binding]; other site 326426002334 G-X-G motif; other site 326426002335 Transcription factor WhiB; Region: Whib; pfam02467 326426002336 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326426002337 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426002338 Walker A/P-loop; other site 326426002339 ATP binding site [chemical binding]; other site 326426002340 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 326426002341 Transcription factor WhiB; Region: Whib; pfam02467 326426002342 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326426002343 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 326426002344 Eukaryotic phosphomannomutase; Region: PMM; cl17107 326426002345 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 326426002346 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326426002347 active site 326426002348 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 326426002349 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326426002350 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326426002351 dimerization interface [polypeptide binding]; other site 326426002352 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326426002353 dimer interface [polypeptide binding]; other site 326426002354 phosphorylation site [posttranslational modification] 326426002355 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426002356 ATP binding site [chemical binding]; other site 326426002357 Mg2+ binding site [ion binding]; other site 326426002358 G-X-G motif; other site 326426002359 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326426002360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426002361 active site 326426002362 phosphorylation site [posttranslational modification] 326426002363 intermolecular recognition site; other site 326426002364 dimerization interface [polypeptide binding]; other site 326426002365 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326426002366 DNA binding site [nucleotide binding] 326426002367 glycogen branching enzyme; Provisional; Region: PRK05402 326426002368 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 326426002369 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 326426002370 active site 326426002371 catalytic site [active] 326426002372 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 326426002373 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 326426002374 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase; Reviewed; Region: ispF; PRK00084 326426002375 homotrimer interaction site [polypeptide binding]; other site 326426002376 zinc binding site [ion binding]; other site 326426002377 CDP-binding sites; other site 326426002378 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 326426002379 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 326426002380 ABC-ATPase subunit interface; other site 326426002381 dimer interface [polypeptide binding]; other site 326426002382 putative PBP binding regions; other site 326426002383 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 326426002384 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 326426002385 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 326426002386 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 326426002387 metal binding site [ion binding]; metal-binding site 326426002388 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 326426002389 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 326426002390 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 326426002391 homodimer interface [polypeptide binding]; other site 326426002392 NADP binding site [chemical binding]; other site 326426002393 substrate binding site [chemical binding]; other site 326426002394 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 326426002395 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 326426002396 RNA binding site [nucleotide binding]; other site 326426002397 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 326426002398 RNA binding site [nucleotide binding]; other site 326426002399 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 326426002400 RNA binding site [nucleotide binding]; other site 326426002401 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 326426002402 RNA binding site [nucleotide binding]; other site 326426002403 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 326426002404 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 326426002405 CoA-binding site [chemical binding]; other site 326426002406 ATP-binding [chemical binding]; other site 326426002407 excinuclease ABC subunit B; Provisional; Region: PRK05298 326426002408 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426002409 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426002410 nucleotide binding region [chemical binding]; other site 326426002411 ATP-binding site [chemical binding]; other site 326426002412 Ultra-violet resistance protein B; Region: UvrB; pfam12344 326426002413 UvrB/uvrC motif; Region: UVR; pfam02151 326426002414 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 326426002415 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 326426002416 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 326426002417 domain interfaces; other site 326426002418 active site 326426002419 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 326426002420 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 326426002421 dimer interface [polypeptide binding]; other site 326426002422 ADP-ribose binding site [chemical binding]; other site 326426002423 active site 326426002424 nudix motif; other site 326426002425 metal binding site [ion binding]; metal-binding site 326426002426 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 326426002427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426002428 active site 326426002429 phosphorylation site [posttranslational modification] 326426002430 intermolecular recognition site; other site 326426002431 dimerization interface [polypeptide binding]; other site 326426002432 ANTAR domain; Region: ANTAR; pfam03861 326426002433 DNA polymerase I; Provisional; Region: PRK05755 326426002434 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 326426002435 active site 326426002436 metal binding site 1 [ion binding]; metal-binding site 326426002437 putative 5' ssDNA interaction site; other site 326426002438 metal binding site 3; metal-binding site 326426002439 metal binding site 2 [ion binding]; metal-binding site 326426002440 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 326426002441 putative DNA binding site [nucleotide binding]; other site 326426002442 putative metal binding site [ion binding]; other site 326426002443 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 326426002444 active site 326426002445 substrate binding site [chemical binding]; other site 326426002446 catalytic site [active] 326426002447 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 326426002448 active site 326426002449 DNA binding site [nucleotide binding] 326426002450 catalytic site [active] 326426002451 Uncharacterized conserved protein [Function unknown]; Region: COG0327 326426002452 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 326426002453 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 326426002454 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 326426002455 dimer interface [polypeptide binding]; other site 326426002456 ADP-ribose binding site [chemical binding]; other site 326426002457 active site 326426002458 nudix motif; other site 326426002459 metal binding site [ion binding]; metal-binding site 326426002460 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 326426002461 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 326426002462 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 326426002463 active site 326426002464 catalytic site [active] 326426002465 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326426002466 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326426002467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326426002468 non-specific DNA binding site [nucleotide binding]; other site 326426002469 salt bridge; other site 326426002470 sequence-specific DNA binding site [nucleotide binding]; other site 326426002471 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 326426002472 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 326426002473 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 326426002474 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 326426002475 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 326426002476 hinge; other site 326426002477 active site 326426002478 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 326426002479 propionate/acetate kinase; Provisional; Region: PRK12379 326426002480 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 326426002481 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 326426002482 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 326426002483 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326426002484 active site 326426002485 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 326426002486 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 326426002487 catalytic triad [active] 326426002488 catalytic triad [active] 326426002489 oxyanion hole [active] 326426002490 GMP synthase; Reviewed; Region: guaA; PRK00074 326426002491 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 326426002492 AMP/PPi binding site [chemical binding]; other site 326426002493 candidate oxyanion hole; other site 326426002494 catalytic triad [active] 326426002495 potential glutamine specificity residues [chemical binding]; other site 326426002496 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 326426002497 ATP Binding subdomain [chemical binding]; other site 326426002498 Ligand Binding sites [chemical binding]; other site 326426002499 Dimerization subdomain; other site 326426002500 putative phosphoketolase; Provisional; Region: PRK05261 326426002501 XFP N-terminal domain; Region: XFP_N; pfam09364 326426002502 XFP C-terminal domain; Region: XFP_C; pfam09363 326426002503 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 326426002504 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 326426002505 Substrate binding site; other site 326426002506 Mg++ binding site; other site 326426002507 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 326426002508 active site 326426002509 substrate binding site [chemical binding]; other site 326426002510 CoA binding site [chemical binding]; other site 326426002511 Oligomerisation domain; Region: Oligomerisation; pfam02410 326426002512 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426002513 catalytic core [active] 326426002514 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 326426002515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426002516 active site 326426002517 motif I; other site 326426002518 motif II; other site 326426002519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426002520 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 326426002521 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 326426002522 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 326426002523 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 326426002524 Walker A/P-loop; other site 326426002525 ATP binding site [chemical binding]; other site 326426002526 Q-loop/lid; other site 326426002527 ABC transporter signature motif; other site 326426002528 Walker B; other site 326426002529 D-loop; other site 326426002530 H-loop/switch region; other site 326426002531 NIL domain; Region: NIL; pfam09383 326426002532 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 326426002533 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 326426002534 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 326426002535 metal binding site [ion binding]; metal-binding site 326426002536 NAD synthetase; Provisional; Region: PRK13981 326426002537 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 326426002538 multimer interface [polypeptide binding]; other site 326426002539 active site 326426002540 catalytic triad [active] 326426002541 protein interface 1 [polypeptide binding]; other site 326426002542 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 326426002543 homodimer interface [polypeptide binding]; other site 326426002544 NAD binding pocket [chemical binding]; other site 326426002545 ATP binding pocket [chemical binding]; other site 326426002546 Mg binding site [ion binding]; other site 326426002547 active-site loop [active] 326426002548 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 326426002549 Pyruvate formate lyase 1; Region: PFL1; cd01678 326426002550 coenzyme A binding site [chemical binding]; other site 326426002551 active site 326426002552 catalytic residues [active] 326426002553 glycine loop; other site 326426002554 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 326426002555 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326426002556 FeS/SAM binding site; other site 326426002557 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 326426002558 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 326426002559 active site 326426002560 substrate binding site [chemical binding]; other site 326426002561 catalytic site [active] 326426002562 HRDC domain; Region: HRDC; pfam00570 326426002563 trigger factor; Provisional; Region: tig; PRK01490 326426002564 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 326426002565 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 326426002566 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 326426002567 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 326426002568 putative ion selectivity filter; other site 326426002569 putative pore gating glutamate residue; other site 326426002570 Clp protease; Region: CLP_protease; pfam00574 326426002571 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 326426002572 oligomer interface [polypeptide binding]; other site 326426002573 active site residues [active] 326426002574 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 326426002575 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 326426002576 oligomer interface [polypeptide binding]; other site 326426002577 active site residues [active] 326426002578 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 326426002579 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 326426002580 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426002581 Walker A motif; other site 326426002582 ATP binding site [chemical binding]; other site 326426002583 Walker B motif; other site 326426002584 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 326426002585 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 326426002586 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426002587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426002588 homodimer interface [polypeptide binding]; other site 326426002589 catalytic residue [active] 326426002590 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 326426002591 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 326426002592 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 326426002593 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326426002594 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 326426002595 Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479 326426002596 L-aspartate oxidase; Provisional; Region: PRK06175 326426002597 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 326426002598 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 326426002599 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 326426002600 DNA protecting protein DprA; Region: dprA; TIGR00732 326426002601 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 326426002602 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 326426002603 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426002604 Walker A motif; other site 326426002605 ATP binding site [chemical binding]; other site 326426002606 Walker B motif; other site 326426002607 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 326426002608 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 326426002609 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 326426002610 dimer interface [polypeptide binding]; other site 326426002611 pyridoxal binding site [chemical binding]; other site 326426002612 ATP binding site [chemical binding]; other site 326426002613 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 326426002614 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 326426002615 homodimer interface [polypeptide binding]; other site 326426002616 substrate-cofactor binding pocket; other site 326426002617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426002618 catalytic residue [active] 326426002619 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426002620 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426002621 Walker A/P-loop; other site 326426002622 ATP binding site [chemical binding]; other site 326426002623 Q-loop/lid; other site 326426002624 ABC transporter signature motif; other site 326426002625 Walker B; other site 326426002626 D-loop; other site 326426002627 H-loop/switch region; other site 326426002628 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326426002629 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426002630 FtsX-like permease family; Region: FtsX; pfam02687 326426002631 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426002632 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326426002633 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426002634 active site 326426002635 phosphorylation site [posttranslational modification] 326426002636 intermolecular recognition site; other site 326426002637 dimerization interface [polypeptide binding]; other site 326426002638 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326426002639 DNA binding residues [nucleotide binding] 326426002640 dimerization interface [polypeptide binding]; other site 326426002641 Histidine kinase; Region: HisKA_3; pfam07730 326426002642 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426002643 ATP binding site [chemical binding]; other site 326426002644 Mg2+ binding site [ion binding]; other site 326426002645 G-X-G motif; other site 326426002646 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 326426002647 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 326426002648 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 326426002649 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 326426002650 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326426002651 substrate binding pocket [chemical binding]; other site 326426002652 membrane-bound complex binding site; other site 326426002653 hinge residues; other site 326426002654 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326426002655 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326426002656 Walker A/P-loop; other site 326426002657 ATP binding site [chemical binding]; other site 326426002658 Q-loop/lid; other site 326426002659 ABC transporter signature motif; other site 326426002660 Walker B; other site 326426002661 D-loop; other site 326426002662 H-loop/switch region; other site 326426002663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426002664 dimer interface [polypeptide binding]; other site 326426002665 conserved gate region; other site 326426002666 ABC-ATPase subunit interface; other site 326426002667 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326426002668 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426002669 dimer interface [polypeptide binding]; other site 326426002670 conserved gate region; other site 326426002671 putative PBP binding loops; other site 326426002672 ABC-ATPase subunit interface; other site 326426002673 GTP-binding protein YchF; Reviewed; Region: PRK09601 326426002674 YchF GTPase; Region: YchF; cd01900 326426002675 G1 box; other site 326426002676 GTP/Mg2+ binding site [chemical binding]; other site 326426002677 Switch I region; other site 326426002678 G2 box; other site 326426002679 Switch II region; other site 326426002680 G3 box; other site 326426002681 G4 box; other site 326426002682 G5 box; other site 326426002683 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 326426002684 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 326426002685 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 326426002686 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 326426002687 TfoX C-terminal domain; Region: TfoX_C; pfam04994 326426002688 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 326426002689 multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575 326426002690 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426002691 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 326426002692 Walker A/P-loop; other site 326426002693 ATP binding site [chemical binding]; other site 326426002694 Q-loop/lid; other site 326426002695 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326426002696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426002697 Walker A/P-loop; other site 326426002698 ATP binding site [chemical binding]; other site 326426002699 Q-loop/lid; other site 326426002700 ABC transporter signature motif; other site 326426002701 Walker B; other site 326426002702 D-loop; other site 326426002703 H-loop/switch region; other site 326426002704 Fic family protein [Function unknown]; Region: COG3177 326426002705 Fic/DOC family; Region: Fic; pfam02661 326426002706 Methyltransferase domain; Region: Methyltransf_23; pfam13489 326426002707 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426002708 S-adenosylmethionine binding site [chemical binding]; other site 326426002709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326426002710 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 326426002711 PemK-like protein; Region: PemK; pfam02452 326426002712 RelB antitoxin; Region: RelB; cl01171 326426002713 HipA-like C-terminal domain; Region: HipA_C; pfam07804 326426002714 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 326426002715 H+ Antiporter protein; Region: 2A0121; TIGR00900 326426002716 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426002717 Integrase core domain; Region: rve; pfam00665 326426002718 transposase/IS protein; Provisional; Region: PRK09183 326426002719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426002720 Walker A motif; other site 326426002721 ATP binding site [chemical binding]; other site 326426002722 Walker B motif; other site 326426002723 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326426002724 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426002725 putative substrate translocation pore; other site 326426002726 FOG: CBS domain [General function prediction only]; Region: COG0517 326426002727 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636 326426002728 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326426002729 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326426002730 active site 326426002731 ATP binding site [chemical binding]; other site 326426002732 substrate binding site [chemical binding]; other site 326426002733 activation loop (A-loop); other site 326426002734 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326426002735 salt bridge; other site 326426002736 non-specific DNA binding site [nucleotide binding]; other site 326426002737 sequence-specific DNA binding site [nucleotide binding]; other site 326426002738 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 326426002739 Short C-terminal domain; Region: SHOCT; pfam09851 326426002740 Excalibur calcium-binding domain; Region: Excalibur; smart00894 326426002741 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326426002742 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326426002743 non-specific DNA binding site [nucleotide binding]; other site 326426002744 salt bridge; other site 326426002745 sequence-specific DNA binding site [nucleotide binding]; other site 326426002746 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 326426002747 Amidohydrolase; Region: Amidohydro_4; pfam13147 326426002748 active site 326426002749 dimer interface [polypeptide binding]; other site 326426002750 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 326426002751 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 326426002752 active site 326426002753 trimer interface [polypeptide binding]; other site 326426002754 allosteric site; other site 326426002755 active site lid [active] 326426002756 hexamer (dimer of trimers) interface [polypeptide binding]; other site 326426002757 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426002758 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326426002759 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426002760 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326426002761 nucleotide binding site [chemical binding]; other site 326426002762 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 326426002763 active site 326426002764 phosphate binding residues; other site 326426002765 catalytic residues [active] 326426002766 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 326426002767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426002768 putative substrate translocation pore; other site 326426002769 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 326426002770 Sulfatase; Region: Sulfatase; cl17466 326426002771 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 326426002772 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326426002773 FeS/SAM binding site; other site 326426002774 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 326426002775 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326426002776 Transposase; Region: HTH_Tnp_1; cl17663 326426002777 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326426002778 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 326426002779 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 326426002780 H+ Antiporter protein; Region: 2A0121; TIGR00900 326426002781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426002782 putative substrate translocation pore; other site 326426002783 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326426002784 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426002785 catalytic core [active] 326426002786 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 326426002787 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326426002788 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326426002789 ATP binding site [chemical binding]; other site 326426002790 putative Mg++ binding site [ion binding]; other site 326426002791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426002792 nucleotide binding region [chemical binding]; other site 326426002793 ATP-binding site [chemical binding]; other site 326426002794 Alpha amylase catalytic domain found in bacterial cyclomaltodextrinases and related proteins; Region: AmyAc_bac_CMD_like; cd11354 326426002795 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 326426002796 active site 326426002797 catalytic site [active] 326426002798 Phosphate transporter family; Region: PHO4; pfam01384 326426002799 Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392 326426002800 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326426002801 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426002802 active site 326426002803 phosphorylation site [posttranslational modification] 326426002804 intermolecular recognition site; other site 326426002805 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326426002806 DNA binding residues [nucleotide binding] 326426002807 dimerization interface [polypeptide binding]; other site 326426002808 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326426002809 Histidine kinase; Region: HisKA_3; pfam07730 326426002810 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426002811 ATP binding site [chemical binding]; other site 326426002812 Mg2+ binding site [ion binding]; other site 326426002813 G-X-G motif; other site 326426002814 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326426002815 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326426002816 Walker A/P-loop; other site 326426002817 ATP binding site [chemical binding]; other site 326426002818 Q-loop/lid; other site 326426002819 ABC transporter signature motif; other site 326426002820 Walker B; other site 326426002821 D-loop; other site 326426002822 H-loop/switch region; other site 326426002823 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 326426002824 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326426002825 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 326426002826 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326426002827 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 326426002828 Divergent AAA domain; Region: AAA_4; pfam04326 326426002829 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 326426002830 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 326426002831 oxyanion hole [active] 326426002832 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 326426002833 conserved cys residue [active] 326426002834 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 326426002835 Isochorismatase family; Region: Isochorismatase; pfam00857 326426002836 catalytic triad [active] 326426002837 metal binding site [ion binding]; metal-binding site 326426002838 conserved cis-peptide bond; other site 326426002839 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326426002840 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 326426002841 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326426002842 salt bridge; other site 326426002843 non-specific DNA binding site [nucleotide binding]; other site 326426002844 sequence-specific DNA binding site [nucleotide binding]; other site 326426002845 xanthine permease; Region: pbuX; TIGR03173 326426002846 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326426002847 active site 326426002848 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326426002849 Part of AAA domain; Region: AAA_19; pfam13245 326426002850 Family description; Region: UvrD_C_2; pfam13538 326426002851 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 326426002852 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426002853 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326426002854 FtsX-like permease family; Region: FtsX; pfam02687 326426002855 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426002856 AAA domain; Region: AAA_21; pfam13304 326426002857 Walker A/P-loop; other site 326426002858 ATP binding site [chemical binding]; other site 326426002859 Q-loop/lid; other site 326426002860 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426002861 ABC transporter signature motif; other site 326426002862 Walker B; other site 326426002863 D-loop; other site 326426002864 H-loop/switch region; other site 326426002865 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 326426002866 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 326426002867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326426002868 RNA binding surface [nucleotide binding]; other site 326426002869 Peptidase C26; Region: Peptidase_C26; pfam07722 326426002870 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 326426002871 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 326426002872 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 326426002873 active site 326426002874 catalytic motif [active] 326426002875 Zn binding site [ion binding]; other site 326426002876 SdpI/YhfL protein family; Region: SdpI; pfam13630 326426002877 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 326426002878 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 326426002879 PemK-like protein; Region: PemK; pfam02452 326426002880 RelB antitoxin; Region: RelB; cl01171 326426002881 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426002882 catalytic core [active] 326426002883 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 326426002884 Bacterial protein of unknown function (DUF948); Region: DUF948; cl01972 326426002885 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 326426002886 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 326426002887 motif 1; other site 326426002888 active site 326426002889 motif 2; other site 326426002890 motif 3; other site 326426002891 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 326426002892 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 326426002893 YceG-like family; Region: YceG; pfam02618 326426002894 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 326426002895 dimerization interface [polypeptide binding]; other site 326426002896 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 326426002897 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 326426002898 Tetramer interface [polypeptide binding]; other site 326426002899 active site 326426002900 FMN-binding site [chemical binding]; other site 326426002901 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 326426002902 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 326426002903 ADP binding site [chemical binding]; other site 326426002904 magnesium binding site [ion binding]; other site 326426002905 putative shikimate binding site; other site 326426002906 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 326426002907 active site 326426002908 dimer interface [polypeptide binding]; other site 326426002909 metal binding site [ion binding]; metal-binding site 326426002910 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 326426002911 Dehydroquinase class II; Region: DHquinase_II; pfam01220 326426002912 trimer interface [polypeptide binding]; other site 326426002913 active site 326426002914 dimer interface [polypeptide binding]; other site 326426002915 CTP synthetase; Validated; Region: pyrG; PRK05380 326426002916 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 326426002917 Catalytic site [active] 326426002918 active site 326426002919 UTP binding site [chemical binding]; other site 326426002920 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 326426002921 active site 326426002922 putative oxyanion hole; other site 326426002923 catalytic triad [active] 326426002924 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 326426002925 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 326426002926 FeS assembly protein SufB; Region: sufB; TIGR01980 326426002927 FeS assembly protein SufD; Region: sufD; TIGR01981 326426002928 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 326426002929 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 326426002930 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 326426002931 Walker A/P-loop; other site 326426002932 ATP binding site [chemical binding]; other site 326426002933 Q-loop/lid; other site 326426002934 ABC transporter signature motif; other site 326426002935 Walker B; other site 326426002936 D-loop; other site 326426002937 H-loop/switch region; other site 326426002938 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 326426002939 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 326426002940 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326426002941 catalytic residue [active] 326426002942 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 326426002943 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 326426002944 trimerization site [polypeptide binding]; other site 326426002945 active site 326426002946 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 326426002947 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 326426002948 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 326426002949 ligand binding site; other site 326426002950 oligomer interface; other site 326426002951 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 326426002952 dimer interface [polypeptide binding]; other site 326426002953 N-terminal domain interface [polypeptide binding]; other site 326426002954 sulfate 1 binding site; other site 326426002955 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 326426002956 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 326426002957 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 326426002958 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 326426002959 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 326426002960 nucleotide binding site/active site [active] 326426002961 HIT family signature motif; other site 326426002962 catalytic residue [active] 326426002963 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 326426002964 PhoH-like protein; Region: PhoH; pfam02562 326426002965 metal-binding heat shock protein; Provisional; Region: PRK00016 326426002966 Domain of unknown function DUF21; Region: DUF21; pfam01595 326426002967 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 326426002968 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 326426002969 Transporter associated domain; Region: CorC_HlyC; smart01091 326426002970 GTPase Era; Reviewed; Region: era; PRK00089 326426002971 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 326426002972 G1 box; other site 326426002973 GTP/Mg2+ binding site [chemical binding]; other site 326426002974 Switch I region; other site 326426002975 G2 box; other site 326426002976 Switch II region; other site 326426002977 G3 box; other site 326426002978 G4 box; other site 326426002979 G5 box; other site 326426002980 KH domain; Region: KH_2; pfam07650 326426002981 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 326426002982 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 326426002983 acyl-activating enzyme (AAE) consensus motif; other site 326426002984 putative AMP binding site [chemical binding]; other site 326426002985 putative active site [active] 326426002986 putative CoA binding site [chemical binding]; other site 326426002987 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 326426002988 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 326426002989 ligand binding site [chemical binding]; other site 326426002990 homodimer interface [polypeptide binding]; other site 326426002991 NAD(P) binding site [chemical binding]; other site 326426002992 trimer interface B [polypeptide binding]; other site 326426002993 trimer interface A [polypeptide binding]; other site 326426002994 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 326426002995 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 326426002996 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 326426002997 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 326426002998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426002999 putative substrate translocation pore; other site 326426003000 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 326426003001 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 326426003002 5S rRNA interface [nucleotide binding]; other site 326426003003 CTC domain interface [polypeptide binding]; other site 326426003004 L16 interface [polypeptide binding]; other site 326426003005 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 326426003006 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 326426003007 homodimer interface [polypeptide binding]; other site 326426003008 substrate-cofactor binding pocket; other site 326426003009 catalytic residue [active] 326426003010 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 326426003011 homodimer interface [polypeptide binding]; other site 326426003012 MazG family protein; Region: mazG; TIGR00444 326426003013 metal binding site [ion binding]; metal-binding site 326426003014 UPF0126 domain; Region: UPF0126; pfam03458 326426003015 Predicted membrane protein [Function unknown]; Region: COG2860 326426003016 UPF0126 domain; Region: UPF0126; pfam03458 326426003017 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 326426003018 GTP-binding protein LepA; Provisional; Region: PRK05433 326426003019 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 326426003020 G1 box; other site 326426003021 putative GEF interaction site [polypeptide binding]; other site 326426003022 GTP/Mg2+ binding site [chemical binding]; other site 326426003023 Switch I region; other site 326426003024 G2 box; other site 326426003025 G3 box; other site 326426003026 Switch II region; other site 326426003027 G4 box; other site 326426003028 G5 box; other site 326426003029 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 326426003030 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 326426003031 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 326426003032 coproporphyrinogen III oxidase; Validated; Region: PRK05628 326426003033 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326426003034 FeS/SAM binding site; other site 326426003035 HemN C-terminal domain; Region: HemN_C; pfam06969 326426003036 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426003037 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426003038 DNA binding site [nucleotide binding] 326426003039 domain linker motif; other site 326426003040 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 326426003041 ligand binding site [chemical binding]; other site 326426003042 dimerization interface (open form) [polypeptide binding]; other site 326426003043 dimerization interface (closed form) [polypeptide binding]; other site 326426003044 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 326426003045 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 326426003046 active site 326426003047 dimer interface [polypeptide binding]; other site 326426003048 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 326426003049 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 326426003050 active site 326426003051 FMN binding site [chemical binding]; other site 326426003052 substrate binding site [chemical binding]; other site 326426003053 3Fe-4S cluster binding site [ion binding]; other site 326426003054 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 326426003055 domain interface; other site 326426003056 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 326426003057 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326426003058 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 326426003059 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326426003060 Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308 326426003061 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 326426003062 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 326426003063 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 326426003064 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426003065 Walker A/P-loop; other site 326426003066 ATP binding site [chemical binding]; other site 326426003067 Q-loop/lid; other site 326426003068 ABC transporter signature motif; other site 326426003069 Walker B; other site 326426003070 D-loop; other site 326426003071 H-loop/switch region; other site 326426003072 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426003073 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326426003074 active site 326426003075 motif I; other site 326426003076 motif II; other site 326426003077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 326426003078 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 326426003079 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 326426003080 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 326426003081 catalytic triad [active] 326426003082 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426003083 Integrase core domain; Region: rve; pfam00665 326426003084 transposase/IS protein; Provisional; Region: PRK09183 326426003085 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426003086 Walker A motif; other site 326426003087 ATP binding site [chemical binding]; other site 326426003088 Walker B motif; other site 326426003089 YfbU domain; Region: YfbU; cl01137 326426003090 Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929 326426003091 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 326426003092 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 326426003093 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 326426003094 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 326426003095 putative ADP-ribose binding site [chemical binding]; other site 326426003096 putative active site [active] 326426003097 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 326426003098 putative active site [active] 326426003099 putative metal binding site [ion binding]; other site 326426003100 Putative transcription activator [Transcription]; Region: TenA; COG0819 326426003101 Predicted esterase [General function prediction only]; Region: COG0400 326426003102 putative hydrolase; Provisional; Region: PRK11460 326426003103 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 326426003104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426003105 S-adenosylmethionine binding site [chemical binding]; other site 326426003106 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426003107 catalytic core [active] 326426003108 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 326426003109 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 326426003110 THF binding site; other site 326426003111 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 326426003112 substrate binding site [chemical binding]; other site 326426003113 THF binding site; other site 326426003114 zinc-binding site [ion binding]; other site 326426003115 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 326426003116 FAD binding site [chemical binding]; other site 326426003117 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 326426003118 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 326426003119 active site 326426003120 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 326426003121 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 326426003122 metal binding triad; other site 326426003123 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 326426003124 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 326426003125 metal binding triad; other site 326426003126 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 326426003127 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 326426003128 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 326426003129 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 326426003130 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 326426003131 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 326426003132 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 326426003133 dihydroorotase; Validated; Region: pyrC; PRK09357 326426003134 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 326426003135 active site 326426003136 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 326426003137 active site 326426003138 dimer interface [polypeptide binding]; other site 326426003139 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 326426003140 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 326426003141 FAD binding pocket [chemical binding]; other site 326426003142 FAD binding motif [chemical binding]; other site 326426003143 phosphate binding motif [ion binding]; other site 326426003144 beta-alpha-beta structure motif; other site 326426003145 NAD binding pocket [chemical binding]; other site 326426003146 Iron coordination center [ion binding]; other site 326426003147 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 326426003148 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 326426003149 heterodimer interface [polypeptide binding]; other site 326426003150 active site 326426003151 FMN binding site [chemical binding]; other site 326426003152 homodimer interface [polypeptide binding]; other site 326426003153 substrate binding site [chemical binding]; other site 326426003154 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326426003155 active site 326426003156 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 326426003157 Transcriptional regulator [Transcription]; Region: LysR; COG0583 326426003158 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 326426003159 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 326426003160 dimerization interface [polypeptide binding]; other site 326426003161 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 326426003162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426003163 motif II; other site 326426003164 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 326426003165 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 326426003166 putative substrate binding site [chemical binding]; other site 326426003167 putative ATP binding site [chemical binding]; other site 326426003168 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326426003169 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426003170 Walker A/P-loop; other site 326426003171 ATP binding site [chemical binding]; other site 326426003172 Q-loop/lid; other site 326426003173 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326426003174 ABC transporter signature motif; other site 326426003175 Walker B; other site 326426003176 D-loop; other site 326426003177 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326426003178 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 326426003179 classical (c) SDRs; Region: SDR_c; cd05233 326426003180 NAD(P) binding site [chemical binding]; other site 326426003181 active site 326426003182 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326426003183 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326426003184 Walker A/P-loop; other site 326426003185 ATP binding site [chemical binding]; other site 326426003186 Q-loop/lid; other site 326426003187 ABC transporter signature motif; other site 326426003188 aspartate aminotransferase; Provisional; Region: PRK06836 326426003189 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426003190 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426003191 homodimer interface [polypeptide binding]; other site 326426003192 catalytic residue [active] 326426003193 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 326426003194 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326426003195 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 326426003196 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 326426003197 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 326426003198 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 326426003199 GIY-YIG motif/motif A; other site 326426003200 active site 326426003201 catalytic site [active] 326426003202 putative DNA binding site [nucleotide binding]; other site 326426003203 metal binding site [ion binding]; metal-binding site 326426003204 UvrB/uvrC motif; Region: UVR; pfam02151 326426003205 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 326426003206 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 326426003207 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 326426003208 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 326426003209 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 326426003210 shikimate binding site; other site 326426003211 NAD(P) binding site [chemical binding]; other site 326426003212 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 326426003213 AAA domain; Region: AAA_33; pfam13671 326426003214 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 326426003215 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 326426003216 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 326426003217 Phosphoglycerate kinase; Region: PGK; pfam00162 326426003218 substrate binding site [chemical binding]; other site 326426003219 hinge regions; other site 326426003220 ADP binding site [chemical binding]; other site 326426003221 catalytic site [active] 326426003222 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 326426003223 triosephosphate isomerase; Provisional; Region: PRK14567 326426003224 substrate binding site [chemical binding]; other site 326426003225 dimer interface [polypeptide binding]; other site 326426003226 catalytic triad [active] 326426003227 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 326426003228 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326426003229 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 326426003230 NAD binding site [chemical binding]; other site 326426003231 dimer interface [polypeptide binding]; other site 326426003232 substrate binding site [chemical binding]; other site 326426003233 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326426003234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426003235 active site 326426003236 motif I; other site 326426003237 motif II; other site 326426003238 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 326426003239 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 326426003240 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326426003241 non-specific DNA binding site [nucleotide binding]; other site 326426003242 salt bridge; other site 326426003243 sequence-specific DNA binding site [nucleotide binding]; other site 326426003244 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426003245 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426003246 homodimer interface [polypeptide binding]; other site 326426003247 catalytic residue [active] 326426003248 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 326426003249 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 326426003250 putative active site [active] 326426003251 transaldolase; Provisional; Region: PRK03903 326426003252 catalytic residue [active] 326426003253 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 326426003254 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 326426003255 TPP-binding site [chemical binding]; other site 326426003256 dimer interface [polypeptide binding]; other site 326426003257 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 326426003258 PYR/PP interface [polypeptide binding]; other site 326426003259 dimer interface [polypeptide binding]; other site 326426003260 TPP binding site [chemical binding]; other site 326426003261 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 326426003262 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 326426003263 HTH domain; Region: HTH_11; pfam08279 326426003264 chaperone protein DnaJ; Provisional; Region: PRK14278 326426003265 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 326426003266 HSP70 interaction site [polypeptide binding]; other site 326426003267 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 326426003268 Zn binding sites [ion binding]; other site 326426003269 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 326426003270 dimer interface [polypeptide binding]; other site 326426003271 Fructosamine kinase; Region: Fructosamin_kin; cl17579 326426003272 Phosphotransferase enzyme family; Region: APH; pfam01636 326426003273 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 326426003274 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 326426003275 thiS-thiF/thiG interaction site; other site 326426003276 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 326426003277 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 326426003278 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 326426003279 active site 326426003280 dimer interface [polypeptide binding]; other site 326426003281 motif 1; other site 326426003282 motif 2; other site 326426003283 motif 3; other site 326426003284 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 326426003285 anticodon binding site; other site 326426003286 FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275 326426003287 nucleotide binding site/active site [active] 326426003288 HIT family signature motif; other site 326426003289 catalytic residue [active] 326426003290 hypothetical protein; Validated; Region: PRK00110 326426003291 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 326426003292 active site 326426003293 putative DNA-binding cleft [nucleotide binding]; other site 326426003294 dimer interface [polypeptide binding]; other site 326426003295 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 326426003296 RuvA N terminal domain; Region: RuvA_N; pfam01330 326426003297 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 326426003298 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 326426003299 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426003300 Walker A motif; other site 326426003301 ATP binding site [chemical binding]; other site 326426003302 Walker B motif; other site 326426003303 arginine finger; other site 326426003304 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326426003305 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 326426003306 Preprotein translocase subunit; Region: YajC; pfam02699 326426003307 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326426003308 active site 326426003309 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 326426003310 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 326426003311 CoA-ligase; Region: Ligase_CoA; pfam00549 326426003312 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 326426003313 CoA binding domain; Region: CoA_binding; pfam02629 326426003314 CoA-ligase; Region: Ligase_CoA; pfam00549 326426003315 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 326426003316 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 326426003317 purine monophosphate binding site [chemical binding]; other site 326426003318 dimer interface [polypeptide binding]; other site 326426003319 putative catalytic residues [active] 326426003320 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 326426003321 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 326426003322 amphipathic channel; other site 326426003323 Asn-Pro-Ala signature motifs; other site 326426003324 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 326426003325 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 326426003326 RNA binding surface [nucleotide binding]; other site 326426003327 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 326426003328 active site 326426003329 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 326426003330 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 326426003331 CMP-binding site; other site 326426003332 The sites determining sugar specificity; other site 326426003333 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 326426003334 G1 box; other site 326426003335 GTP/Mg2+ binding site [chemical binding]; other site 326426003336 Switch I region; other site 326426003337 G2 box; other site 326426003338 Switch II region; other site 326426003339 G3 box; other site 326426003340 G4 box; other site 326426003341 G5 box; other site 326426003342 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 326426003343 G1 box; other site 326426003344 GTP/Mg2+ binding site [chemical binding]; other site 326426003345 Switch I region; other site 326426003346 G2 box; other site 326426003347 G3 box; other site 326426003348 Switch II region; other site 326426003349 G4 box; other site 326426003350 G5 box; other site 326426003351 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 326426003352 Eukaryotic phosphomannomutase; Region: PMM; cl17107 326426003353 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426003354 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326426003355 active site 326426003356 Predicted transcriptional regulator [Transcription]; Region: COG2378 326426003357 WYL domain; Region: WYL; pfam13280 326426003358 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326426003359 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426003360 ATP binding site [chemical binding]; other site 326426003361 putative Mg++ binding site [ion binding]; other site 326426003362 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426003363 nucleotide binding region [chemical binding]; other site 326426003364 ATP-binding site [chemical binding]; other site 326426003365 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 326426003366 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 326426003367 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 326426003368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426003369 motif II; other site 326426003370 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326426003371 DNA binding residues [nucleotide binding] 326426003372 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 326426003373 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 326426003374 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326426003375 phosphopeptide binding site; other site 326426003376 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 326426003377 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 326426003378 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 326426003379 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 326426003380 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 326426003381 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 326426003382 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 326426003383 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 326426003384 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 326426003385 homodimer interface [polypeptide binding]; other site 326426003386 putative metal binding site [ion binding]; other site 326426003387 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 326426003388 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 326426003389 substrate binding site [chemical binding]; other site 326426003390 hexamer interface [polypeptide binding]; other site 326426003391 metal binding site [ion binding]; metal-binding site 326426003392 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 326426003393 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 326426003394 substrate binding site [chemical binding]; other site 326426003395 active site 326426003396 catalytic residues [active] 326426003397 heterodimer interface [polypeptide binding]; other site 326426003398 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 326426003399 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 326426003400 active site 326426003401 ribulose/triose binding site [chemical binding]; other site 326426003402 phosphate binding site [ion binding]; other site 326426003403 substrate (anthranilate) binding pocket [chemical binding]; other site 326426003404 product (indole) binding pocket [chemical binding]; other site 326426003405 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 326426003406 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426003407 catalytic residue [active] 326426003408 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 326426003409 endonuclease IV; Provisional; Region: PRK01060 326426003410 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 326426003411 AP (apurinic/apyrimidinic) site pocket; other site 326426003412 DNA interaction; other site 326426003413 Metal-binding active site; metal-binding site 326426003414 S-methylmethionine transporter; Provisional; Region: PRK11387 326426003415 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426003416 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326426003417 putative substrate translocation pore; other site 326426003418 VanZ like family; Region: VanZ; pfam04892 326426003419 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 326426003420 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 326426003421 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326426003422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326426003423 Coenzyme A binding pocket [chemical binding]; other site 326426003424 Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805 326426003425 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326426003426 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326426003427 Abi-like protein; Region: Abi_2; pfam07751 326426003428 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326426003429 Histidine kinase; Region: HisKA_3; pfam07730 326426003430 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326426003431 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426003432 active site 326426003433 phosphorylation site [posttranslational modification] 326426003434 intermolecular recognition site; other site 326426003435 dimerization interface [polypeptide binding]; other site 326426003436 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326426003437 DNA binding residues [nucleotide binding] 326426003438 dimerization interface [polypeptide binding]; other site 326426003439 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 326426003440 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 326426003441 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426003442 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426003443 Walker A/P-loop; other site 326426003444 ATP binding site [chemical binding]; other site 326426003445 Q-loop/lid; other site 326426003446 ABC transporter signature motif; other site 326426003447 Walker B; other site 326426003448 D-loop; other site 326426003449 H-loop/switch region; other site 326426003450 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426003451 RelB antitoxin; Region: RelB; cl01171 326426003452 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396 326426003453 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 326426003454 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326426003455 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 326426003456 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 326426003457 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 326426003458 Walker A/P-loop; other site 326426003459 ATP binding site [chemical binding]; other site 326426003460 Q-loop/lid; other site 326426003461 ABC transporter signature motif; other site 326426003462 Walker B; other site 326426003463 D-loop; other site 326426003464 H-loop/switch region; other site 326426003465 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 326426003466 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326426003467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426003468 Walker A/P-loop; other site 326426003469 ATP binding site [chemical binding]; other site 326426003470 Q-loop/lid; other site 326426003471 ABC transporter signature motif; other site 326426003472 Walker B; other site 326426003473 D-loop; other site 326426003474 H-loop/switch region; other site 326426003475 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326426003476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426003477 active site 326426003478 phosphorylation site [posttranslational modification] 326426003479 intermolecular recognition site; other site 326426003480 dimerization interface [polypeptide binding]; other site 326426003481 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326426003482 DNA binding residues [nucleotide binding] 326426003483 dimerization interface [polypeptide binding]; other site 326426003484 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326426003485 Histidine kinase; Region: HisKA_3; pfam07730 326426003486 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 326426003487 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426003488 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426003489 Walker A/P-loop; other site 326426003490 ATP binding site [chemical binding]; other site 326426003491 Q-loop/lid; other site 326426003492 ABC transporter signature motif; other site 326426003493 Walker B; other site 326426003494 D-loop; other site 326426003495 H-loop/switch region; other site 326426003496 Protein of unknown function (DUF2089); Region: DUF2089; pfam09862 326426003497 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326426003498 DNA binding residues [nucleotide binding] 326426003499 HipA N-terminal domain; Region: Couple_hipA; cl11853 326426003500 S-methylmethionine transporter; Provisional; Region: PRK11387 326426003501 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 326426003502 Uncharacterized conserved protein [Function unknown]; Region: COG3189 326426003503 Domain of unknown function (DUF1287); Region: DUF1287; cl01519 326426003504 anthranilate synthase component I; Provisional; Region: PRK13571 326426003505 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 326426003506 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 326426003507 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 326426003508 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 326426003509 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 326426003510 substrate binding site [chemical binding]; other site 326426003511 glutamase interaction surface [polypeptide binding]; other site 326426003512 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 326426003513 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326426003514 FeS/SAM binding site; other site 326426003515 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 326426003516 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 326426003517 ribosome recycling factor; Reviewed; Region: frr; PRK00083 326426003518 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 326426003519 hinge region; other site 326426003520 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 326426003521 putative nucleotide binding site [chemical binding]; other site 326426003522 uridine monophosphate binding site [chemical binding]; other site 326426003523 homohexameric interface [polypeptide binding]; other site 326426003524 elongation factor Ts; Provisional; Region: tsf; PRK09377 326426003525 Elongation factor TS; Region: EF_TS; pfam00889 326426003526 Elongation factor TS; Region: EF_TS; pfam00889 326426003527 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 326426003528 rRNA interaction site [nucleotide binding]; other site 326426003529 S8 interaction site; other site 326426003530 putative laminin-1 binding site; other site 326426003531 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 326426003532 active site 326426003533 catalytic residues [active] 326426003534 metal binding site [ion binding]; metal-binding site 326426003535 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 326426003536 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 326426003537 acyl-activating enzyme (AAE) consensus motif; other site 326426003538 putative AMP binding site [chemical binding]; other site 326426003539 putative active site [active] 326426003540 putative CoA binding site [chemical binding]; other site 326426003541 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 326426003542 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 326426003543 active site 326426003544 isocitrate dehydrogenase; Validated; Region: PRK08299 326426003545 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326426003546 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326426003547 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 326426003548 Peptidase family M23; Region: Peptidase_M23; pfam01551 326426003549 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 326426003550 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 326426003551 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426003552 DNA-binding interface [nucleotide binding]; DNA binding site 326426003553 Integrase core domain; Region: rve; pfam00665 326426003554 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326426003555 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426003556 Walker A motif; other site 326426003557 ATP binding site [chemical binding]; other site 326426003558 Walker B motif; other site 326426003559 BsuBI/PstI restriction endonuclease C-terminus; Region: BsuBI_PstI_RE; pfam06616 326426003560 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426003561 S-adenosylmethionine binding site [chemical binding]; other site 326426003562 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 326426003563 ATP binding site [chemical binding]; other site 326426003564 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 326426003565 Mg2+ binding site [ion binding]; other site 326426003566 G-X-G motif; other site 326426003567 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 326426003568 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 326426003569 cofactor binding site; other site 326426003570 DNA binding site [nucleotide binding] 326426003571 substrate interaction site [chemical binding]; other site 326426003572 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 326426003573 active site 326426003574 metal binding site [ion binding]; metal-binding site 326426003575 DNA topoisomerase; Region: Topoisom_bac; pfam01131 326426003576 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cl11986 326426003577 domain I; other site 326426003578 DNA binding groove [nucleotide binding] 326426003579 phosphate binding site [ion binding]; other site 326426003580 domain II; other site 326426003581 domain III; other site 326426003582 nucleotide binding site [chemical binding]; other site 326426003583 catalytic site [active] 326426003584 domain IV; other site 326426003585 C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342 326426003586 UGMP family protein; Validated; Region: PRK09604 326426003587 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 326426003588 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 326426003589 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326426003590 Coenzyme A binding pocket [chemical binding]; other site 326426003591 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 326426003592 Glycoprotease family; Region: Peptidase_M22; pfam00814 326426003593 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 326426003594 DNA polymerase III, delta subunit; Region: holA; TIGR01128 326426003595 Competence protein; Region: Competence; pfam03772 326426003596 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 326426003597 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 326426003598 Helix-hairpin-helix motif; Region: HHH; pfam00633 326426003599 aminoacyl-tRNA ligase; Region: PLN02563 326426003600 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326426003601 active site 326426003602 HIGH motif; other site 326426003603 nucleotide binding site [chemical binding]; other site 326426003604 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326426003605 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 326426003606 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326426003607 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326426003608 active site 326426003609 KMSKS motif; other site 326426003610 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 326426003611 tRNA binding surface [nucleotide binding]; other site 326426003612 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 326426003613 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326426003614 substrate binding pocket [chemical binding]; other site 326426003615 membrane-bound complex binding site; other site 326426003616 hinge residues; other site 326426003617 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 326426003618 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 326426003619 Cl binding site [ion binding]; other site 326426003620 oligomer interface [polypeptide binding]; other site 326426003621 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426003622 catalytic core [active] 326426003623 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 326426003624 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 326426003625 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 326426003626 EamA-like transporter family; Region: EamA; pfam00892 326426003627 EamA-like transporter family; Region: EamA; pfam00892 326426003628 Nitroreductase family; Region: Nitroreductase; pfam00881 326426003629 FMN binding site [chemical binding]; other site 326426003630 dimer interface [polypeptide binding]; other site 326426003631 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 326426003632 Uncharacterized conserved protein [Function unknown]; Region: COG3538 326426003633 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 326426003634 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 326426003635 putative active cleft [active] 326426003636 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426003637 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426003638 DNA binding site [nucleotide binding] 326426003639 domain linker motif; other site 326426003640 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426003641 ligand binding site [chemical binding]; other site 326426003642 dimerization interface [polypeptide binding]; other site 326426003643 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 326426003644 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 326426003645 putative active site [active] 326426003646 Repeats in polycystic kidney disease 1 (PKD1) and other proteins; Region: PKD; smart00089 326426003647 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 326426003648 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 326426003649 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 326426003650 putative active site [active] 326426003651 putative catalytic site [active] 326426003652 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426003653 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426003654 putative PBP binding loops; other site 326426003655 dimer interface [polypeptide binding]; other site 326426003656 ABC-ATPase subunit interface; other site 326426003657 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426003658 dimer interface [polypeptide binding]; other site 326426003659 conserved gate region; other site 326426003660 putative PBP binding loops; other site 326426003661 ABC-ATPase subunit interface; other site 326426003662 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426003663 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426003664 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 326426003665 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 326426003666 active site 326426003667 catalytic site [active] 326426003668 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 326426003669 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 326426003670 active site 326426003671 catalytic site [active] 326426003672 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 326426003673 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 326426003674 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 326426003675 active site 326426003676 catalytic site [active] 326426003677 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 326426003678 Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748 326426003679 Fic family protein [Function unknown]; Region: COG3177 326426003680 Fic/DOC family; Region: Fic; pfam02661 326426003681 HipA-like C-terminal domain; Region: HipA_C; pfam07804 326426003682 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 326426003683 active site 326426003684 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 326426003685 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326426003686 Zn2+ binding site [ion binding]; other site 326426003687 Mg2+ binding site [ion binding]; other site 326426003688 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 326426003689 synthetase active site [active] 326426003690 NTP binding site [chemical binding]; other site 326426003691 metal binding site [ion binding]; metal-binding site 326426003692 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 326426003693 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 326426003694 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 326426003695 trimer interface [polypeptide binding]; other site 326426003696 active site 326426003697 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 326426003698 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 326426003699 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 326426003700 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 326426003701 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 326426003702 CAP-like domain; other site 326426003703 active site 326426003704 primary dimer interface [polypeptide binding]; other site 326426003705 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 326426003706 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 326426003707 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 326426003708 transposase/IS protein; Provisional; Region: PRK09183 326426003709 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426003710 Walker A motif; other site 326426003711 ATP binding site [chemical binding]; other site 326426003712 Walker B motif; other site 326426003713 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426003714 Integrase core domain; Region: rve; pfam00665 326426003715 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426003716 ATP binding site [chemical binding]; other site 326426003717 putative Mg++ binding site [ion binding]; other site 326426003718 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426003719 nucleotide binding region [chemical binding]; other site 326426003720 ATP-binding site [chemical binding]; other site 326426003721 DEAD/H associated; Region: DEAD_assoc; pfam08494 326426003722 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 326426003723 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326426003724 substrate binding site [chemical binding]; other site 326426003725 dimer interface [polypeptide binding]; other site 326426003726 ATP binding site [chemical binding]; other site 326426003727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426003728 putative substrate translocation pore; other site 326426003729 D-galactonate transporter; Region: 2A0114; TIGR00893 326426003730 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426003731 Mg2+ binding site [ion binding]; other site 326426003732 G-X-G motif; other site 326426003733 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 326426003734 anchoring element; other site 326426003735 dimer interface [polypeptide binding]; other site 326426003736 ATP binding site [chemical binding]; other site 326426003737 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 326426003738 active site 326426003739 putative metal-binding site [ion binding]; other site 326426003740 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 326426003741 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 326426003742 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 326426003743 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326426003744 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 326426003745 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326426003746 DNA binding residues [nucleotide binding] 326426003747 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 326426003748 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 326426003749 substrate binding pocket [chemical binding]; other site 326426003750 chain length determination region; other site 326426003751 substrate-Mg2+ binding site; other site 326426003752 catalytic residues [active] 326426003753 aspartate-rich region 1; other site 326426003754 active site lid residues [active] 326426003755 aspartate-rich region 2; other site 326426003756 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326426003757 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326426003758 active site 326426003759 ATP binding site [chemical binding]; other site 326426003760 substrate binding site [chemical binding]; other site 326426003761 activation loop (A-loop); other site 326426003762 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326426003763 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326426003764 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 326426003765 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 326426003766 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 326426003767 putative acyl-acceptor binding pocket; other site 326426003768 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 326426003769 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 326426003770 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 326426003771 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 326426003772 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426003773 ATP binding site [chemical binding]; other site 326426003774 putative Mg++ binding site [ion binding]; other site 326426003775 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 326426003776 SEC-C motif; Region: SEC-C; pfam02810 326426003777 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 326426003778 30S subunit binding site; other site 326426003779 recombination regulator RecX; Reviewed; Region: recX; PRK00117 326426003780 recombinase A; Provisional; Region: recA; PRK09354 326426003781 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 326426003782 hexamer interface [polypeptide binding]; other site 326426003783 Walker A motif; other site 326426003784 ATP binding site [chemical binding]; other site 326426003785 Walker B motif; other site 326426003786 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 326426003787 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326426003788 sequence-specific DNA binding site [nucleotide binding]; other site 326426003789 salt bridge; other site 326426003790 Competence-damaged protein; Region: CinA; pfam02464 326426003791 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 326426003792 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 326426003793 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 326426003794 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 326426003795 Fic/DOC family; Region: Fic; cl00960 326426003796 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 326426003797 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 326426003798 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 326426003799 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 326426003800 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 326426003801 FeS/SAM binding site; other site 326426003802 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 326426003803 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 326426003804 synthetase active site [active] 326426003805 NTP binding site [chemical binding]; other site 326426003806 metal binding site [ion binding]; metal-binding site 326426003807 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 326426003808 EamA-like transporter family; Region: EamA; cl17759 326426003809 EamA-like transporter family; Region: EamA; pfam00892 326426003810 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 326426003811 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 326426003812 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426003813 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326426003814 active site 326426003815 phosphorylation site [posttranslational modification] 326426003816 intermolecular recognition site; other site 326426003817 dimerization interface [polypeptide binding]; other site 326426003818 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326426003819 DNA binding residues [nucleotide binding] 326426003820 dimerization interface [polypeptide binding]; other site 326426003821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326426003822 Coenzyme A binding pocket [chemical binding]; other site 326426003823 aconitate hydratase; Validated; Region: PRK09277 326426003824 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 326426003825 substrate binding site [chemical binding]; other site 326426003826 ligand binding site [chemical binding]; other site 326426003827 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 326426003828 substrate binding site [chemical binding]; other site 326426003829 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 326426003830 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326426003831 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426003832 motif II; other site 326426003833 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 326426003834 TRAM domain; Region: TRAM; cl01282 326426003835 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426003836 S-adenosylmethionine binding site [chemical binding]; other site 326426003837 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 326426003838 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 326426003839 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 326426003840 putative active site [active] 326426003841 putative catalytic site [active] 326426003842 putative DNA binding site [nucleotide binding]; other site 326426003843 putative phosphate binding site [ion binding]; other site 326426003844 metal binding site A [ion binding]; metal-binding site 326426003845 putative AP binding site [nucleotide binding]; other site 326426003846 putative metal binding site B [ion binding]; other site 326426003847 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326426003848 AAA domain; Region: AAA_21; pfam13304 326426003849 Walker A/P-loop; other site 326426003850 ATP binding site [chemical binding]; other site 326426003851 Q-loop/lid; other site 326426003852 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326426003853 ABC transporter signature motif; other site 326426003854 Walker B; other site 326426003855 D-loop; other site 326426003856 H-loop/switch region; other site 326426003857 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326426003858 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326426003859 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 326426003860 Walker A/P-loop; other site 326426003861 ATP binding site [chemical binding]; other site 326426003862 Q-loop/lid; other site 326426003863 ABC transporter signature motif; other site 326426003864 Walker B; other site 326426003865 D-loop; other site 326426003866 H-loop/switch region; other site 326426003867 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326426003868 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326426003869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426003870 dimer interface [polypeptide binding]; other site 326426003871 conserved gate region; other site 326426003872 putative PBP binding loops; other site 326426003873 ABC-ATPase subunit interface; other site 326426003874 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326426003875 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426003876 dimer interface [polypeptide binding]; other site 326426003877 conserved gate region; other site 326426003878 putative PBP binding loops; other site 326426003879 ABC-ATPase subunit interface; other site 326426003880 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 326426003881 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326426003882 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 326426003883 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326426003884 active site 326426003885 DNA binding site [nucleotide binding] 326426003886 Int/Topo IB signature motif; other site 326426003887 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426003888 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426003889 Walker A/P-loop; other site 326426003890 ATP binding site [chemical binding]; other site 326426003891 Q-loop/lid; other site 326426003892 ABC transporter signature motif; other site 326426003893 Walker B; other site 326426003894 D-loop; other site 326426003895 H-loop/switch region; other site 326426003896 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426003897 FtsX-like permease family; Region: FtsX; pfam02687 326426003898 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426003899 FtsX-like permease family; Region: FtsX; pfam02687 326426003900 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 326426003901 prephenate dehydrogenase; Validated; Region: PRK08507 326426003902 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 326426003903 Prephenate dehydratase; Region: PDT; pfam00800 326426003904 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 326426003905 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 326426003906 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 326426003907 G1 box; other site 326426003908 putative GEF interaction site [polypeptide binding]; other site 326426003909 GTP/Mg2+ binding site [chemical binding]; other site 326426003910 Switch I region; other site 326426003911 G2 box; other site 326426003912 G3 box; other site 326426003913 Switch II region; other site 326426003914 G4 box; other site 326426003915 G5 box; other site 326426003916 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 326426003917 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 326426003918 Predicted transcriptional regulators [Transcription]; Region: COG1695 326426003919 Transcriptional regulator PadR-like family; Region: PadR; cl17335 326426003920 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426003921 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426003922 Walker A/P-loop; other site 326426003923 ATP binding site [chemical binding]; other site 326426003924 Q-loop/lid; other site 326426003925 ABC transporter signature motif; other site 326426003926 Walker B; other site 326426003927 D-loop; other site 326426003928 H-loop/switch region; other site 326426003929 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 326426003930 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 326426003931 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326426003932 catalytic residue [active] 326426003933 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06543 326426003934 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 326426003935 dimerization interface [polypeptide binding]; other site 326426003936 active site 326426003937 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 326426003938 L-aspartate oxidase; Provisional; Region: PRK06175 326426003939 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 326426003940 quinolinate synthetase; Provisional; Region: PRK09375 326426003941 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 326426003942 nudix motif; other site 326426003943 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 326426003944 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 326426003945 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 326426003946 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326426003947 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326426003948 P-loop; other site 326426003949 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 326426003950 Magnesium ion binding site [ion binding]; other site 326426003951 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326426003952 Magnesium ion binding site [ion binding]; other site 326426003953 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 326426003954 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 326426003955 active site 326426003956 Int/Topo IB signature motif; other site 326426003957 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 326426003958 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 326426003959 23S rRNA binding site [nucleotide binding]; other site 326426003960 L21 binding site [polypeptide binding]; other site 326426003961 L13 binding site [polypeptide binding]; other site 326426003962 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 326426003963 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 326426003964 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 326426003965 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 326426003966 Thiamine pyrophosphokinase; Region: TPK; cd07995 326426003967 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 326426003968 active site 326426003969 dimerization interface [polypeptide binding]; other site 326426003970 thiamine binding site [chemical binding]; other site 326426003971 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 326426003972 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 326426003973 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 326426003974 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 326426003975 putative deacylase active site [active] 326426003976 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 326426003977 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 326426003978 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 326426003979 active site 326426003980 catalytic residues [active] 326426003981 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 326426003982 active site 326426003983 catalytic residues [active] 326426003984 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 326426003985 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 326426003986 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 326426003987 DNA binding residues [nucleotide binding] 326426003988 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 326426003989 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326426003990 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326426003991 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326426003992 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 326426003993 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 326426003994 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 326426003995 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 326426003996 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 326426003997 Walker A/P-loop; other site 326426003998 ATP binding site [chemical binding]; other site 326426003999 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; pfam06470 326426004000 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 326426004001 ABC transporter signature motif; other site 326426004002 Walker B; other site 326426004003 D-loop; other site 326426004004 H-loop/switch region; other site 326426004005 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 326426004006 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326426004007 proline aminopeptidase P II; Provisional; Region: PRK10879 326426004008 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 326426004009 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 326426004010 active site 326426004011 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 326426004012 nudix motif; other site 326426004013 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 326426004014 Amidohydrolase; Region: Amidohydro_4; pfam13147 326426004015 active site 326426004016 dimer interface [polypeptide binding]; other site 326426004017 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 326426004018 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 326426004019 active site 326426004020 trimer interface [polypeptide binding]; other site 326426004021 allosteric site; other site 326426004022 active site lid [active] 326426004023 hexamer (dimer of trimers) interface [polypeptide binding]; other site 326426004024 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426004025 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326426004026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426004027 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326426004028 nucleotide binding site [chemical binding]; other site 326426004029 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326426004030 putative DNA binding site [nucleotide binding]; other site 326426004031 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326426004032 putative Zn2+ binding site [ion binding]; other site 326426004033 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426004034 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326426004035 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326426004036 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326426004037 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 326426004038 putative substrate binding site [chemical binding]; other site 326426004039 putative ATP binding site [chemical binding]; other site 326426004040 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 326426004041 putative active site [active] 326426004042 dimerization interface [polypeptide binding]; other site 326426004043 putative tRNAtyr binding site [nucleotide binding]; other site 326426004044 cell division protein FtsQ; Provisional; Region: PRK05529 326426004045 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 326426004046 Cell division protein FtsQ; Region: FtsQ; pfam03799 326426004047 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 326426004048 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326426004049 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326426004050 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326426004051 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 326426004052 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 326426004053 active site 326426004054 homodimer interface [polypeptide binding]; other site 326426004055 cell division protein FtsW; Region: ftsW; TIGR02614 326426004056 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 326426004057 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 326426004058 NAD binding site [chemical binding]; other site 326426004059 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326426004060 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 326426004061 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 326426004062 Mg++ binding site [ion binding]; other site 326426004063 putative catalytic motif [active] 326426004064 putative substrate binding site [chemical binding]; other site 326426004065 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 326426004066 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 326426004067 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 326426004068 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 326426004069 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 326426004070 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 326426004071 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 326426004072 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 326426004073 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 326426004074 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426004075 S-adenosylmethionine binding site [chemical binding]; other site 326426004076 cell division protein MraZ; Reviewed; Region: PRK00326 326426004077 MraZ protein; Region: MraZ; pfam02381 326426004078 MraZ protein; Region: MraZ; pfam02381 326426004079 Part of AAA domain; Region: AAA_19; pfam13245 326426004080 Family description; Region: UvrD_C_2; pfam13538 326426004081 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 326426004082 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 326426004083 ligand binding site [chemical binding]; other site 326426004084 NAD binding site [chemical binding]; other site 326426004085 tetramer interface [polypeptide binding]; other site 326426004086 catalytic site [active] 326426004087 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 326426004088 L-serine binding site [chemical binding]; other site 326426004089 ACT domain interface; other site 326426004090 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 326426004091 ATP cone domain; Region: ATP-cone; pfam03477 326426004092 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 326426004093 LexA repressor; Validated; Region: PRK00215 326426004094 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 326426004095 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 326426004096 Catalytic site [active] 326426004097 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 326426004098 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 326426004099 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 326426004100 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 326426004101 NAD binding site [chemical binding]; other site 326426004102 dimer interface [polypeptide binding]; other site 326426004103 substrate binding site [chemical binding]; other site 326426004104 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326426004105 GTPases [General function prediction only]; Region: HflX; COG2262 326426004106 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 326426004107 HflX GTPase family; Region: HflX; cd01878 326426004108 G1 box; other site 326426004109 GTP/Mg2+ binding site [chemical binding]; other site 326426004110 Switch I region; other site 326426004111 G2 box; other site 326426004112 G3 box; other site 326426004113 Switch II region; other site 326426004114 G4 box; other site 326426004115 G5 box; other site 326426004116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426004117 S-adenosylmethionine binding site [chemical binding]; other site 326426004118 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 326426004119 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426004120 ATP binding site [chemical binding]; other site 326426004121 putative Mg++ binding site [ion binding]; other site 326426004122 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426004123 nucleotide binding region [chemical binding]; other site 326426004124 ATP-binding site [chemical binding]; other site 326426004125 Helicase associated domain (HA2); Region: HA2; pfam04408 326426004126 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 326426004127 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 326426004128 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326426004129 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426004130 putative substrate translocation pore; other site 326426004131 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 326426004132 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 326426004133 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 326426004134 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 326426004135 Uncharacterized protein conserved in bacteria (DUF2252); Region: DUF2252; pfam10009 326426004136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4320 326426004137 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 326426004138 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 326426004139 catalytic residues [active] 326426004140 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 326426004141 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 326426004142 putative active site [active] 326426004143 oxyanion strand; other site 326426004144 catalytic triad [active] 326426004145 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 326426004146 putative active site pocket [active] 326426004147 4-fold oligomerization interface [polypeptide binding]; other site 326426004148 metal binding residues [ion binding]; metal-binding site 326426004149 3-fold/trimer interface [polypeptide binding]; other site 326426004150 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 326426004151 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426004152 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426004153 homodimer interface [polypeptide binding]; other site 326426004154 catalytic residue [active] 326426004155 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 326426004156 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 326426004157 NAD binding site [chemical binding]; other site 326426004158 dimerization interface [polypeptide binding]; other site 326426004159 product binding site; other site 326426004160 substrate binding site [chemical binding]; other site 326426004161 zinc binding site [ion binding]; other site 326426004162 catalytic residues [active] 326426004163 Acylphosphatase; Region: Acylphosphatase; cl00551 326426004164 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326426004165 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326426004166 active site 326426004167 catalytic tetrad [active] 326426004168 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 326426004169 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 326426004170 inhibitor site; inhibition site 326426004171 active site 326426004172 dimer interface [polypeptide binding]; other site 326426004173 catalytic residue [active] 326426004174 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 326426004175 Amidohydrolase; Region: Amidohydro_2; pfam04909 326426004176 short chain dehydrogenase; Provisional; Region: PRK08628 326426004177 classical (c) SDRs; Region: SDR_c; cd05233 326426004178 NAD(P) binding site [chemical binding]; other site 326426004179 active site 326426004180 myosin-cross-reactive antigen; Provisional; Region: PRK13977 326426004181 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326426004182 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326426004183 active site 326426004184 catalytic tetrad [active] 326426004185 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 326426004186 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 326426004187 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 326426004188 active site 326426004189 PHP Thumb interface [polypeptide binding]; other site 326426004190 metal binding site [ion binding]; metal-binding site 326426004191 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 326426004192 generic binding surface II; other site 326426004193 generic binding surface I; other site 326426004194 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326426004195 putative Zn2+ binding site [ion binding]; other site 326426004196 WYL domain; Region: WYL; pfam13280 326426004197 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 326426004198 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 326426004199 active site 326426004200 lipoprotein signal peptidase; Provisional; Region: PRK14771 326426004201 DivIVA protein; Region: DivIVA; pfam05103 326426004202 DivIVA domain; Region: DivI1A_domain; TIGR03544 326426004203 YGGT family; Region: YGGT; pfam02325 326426004204 Protein of unknown function (DUF552); Region: DUF552; pfam04472 326426004205 cell division protein FtsZ; Validated; Region: PRK09330 326426004206 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 326426004207 nucleotide binding site [chemical binding]; other site 326426004208 SulA interaction site; other site 326426004209 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 326426004210 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 326426004211 FMN binding site [chemical binding]; other site 326426004212 active site 326426004213 catalytic residues [active] 326426004214 substrate binding site [chemical binding]; other site 326426004215 glycyl-tRNA synthetase; Provisional; Region: PRK04173 326426004216 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326426004217 motif 1; other site 326426004218 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 326426004219 active site 326426004220 motif 2; other site 326426004221 motif 3; other site 326426004222 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 326426004223 anticodon binding site; other site 326426004224 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326426004225 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326426004226 Walker A/P-loop; other site 326426004227 ATP binding site [chemical binding]; other site 326426004228 Q-loop/lid; other site 326426004229 ABC transporter signature motif; other site 326426004230 Walker B; other site 326426004231 D-loop; other site 326426004232 H-loop/switch region; other site 326426004233 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 326426004234 putative DNA binding site [nucleotide binding]; other site 326426004235 dimerization interface [polypeptide binding]; other site 326426004236 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326426004237 putative Zn2+ binding site [ion binding]; other site 326426004238 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 326426004239 substrate binding site [chemical binding]; other site 326426004240 multimerization interface [polypeptide binding]; other site 326426004241 ATP binding site [chemical binding]; other site 326426004242 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 326426004243 thiamine phosphate binding site [chemical binding]; other site 326426004244 active site 326426004245 pyrophosphate binding site [ion binding]; other site 326426004246 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 326426004247 ThiC-associated domain; Region: ThiC-associated; pfam13667 326426004248 ThiC family; Region: ThiC; pfam01964 326426004249 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004250 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 326426004251 Walker A motif; other site 326426004252 ATP binding site [chemical binding]; other site 326426004253 Walker B motif; other site 326426004254 arginine finger; other site 326426004255 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 326426004256 substrate binding site [chemical binding]; other site 326426004257 dimer interface [polypeptide binding]; other site 326426004258 ATP binding site [chemical binding]; other site 326426004259 Domain of unknown function DUF77; Region: DUF77; pfam01910 326426004260 benzoate transport; Region: 2A0115; TIGR00895 326426004261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426004262 putative substrate translocation pore; other site 326426004263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426004264 putative substrate translocation pore; other site 326426004265 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326426004266 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326426004267 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426004268 active site 326426004269 phosphorylation site [posttranslational modification] 326426004270 intermolecular recognition site; other site 326426004271 dimerization interface [polypeptide binding]; other site 326426004272 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326426004273 DNA binding residues [nucleotide binding] 326426004274 dimerization interface [polypeptide binding]; other site 326426004275 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 326426004276 serpin-like protein; Provisional; Region: PHA02660 326426004277 reactive center loop; other site 326426004278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426004279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426004280 DNA binding site [nucleotide binding] 326426004281 domain linker motif; other site 326426004282 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 326426004283 putative dimerization interface [polypeptide binding]; other site 326426004284 putative ligand binding site [chemical binding]; other site 326426004285 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 326426004286 galactoside permease; Reviewed; Region: lacY; PRK09528 326426004287 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 326426004288 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 326426004289 substrate binding [chemical binding]; other site 326426004290 active site 326426004291 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 326426004292 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426004293 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326426004294 nucleotide binding site [chemical binding]; other site 326426004295 Nitroreductase family; Region: Nitroreductase; pfam00881 326426004296 FMN binding site [chemical binding]; other site 326426004297 dimer interface [polypeptide binding]; other site 326426004298 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 326426004299 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326426004300 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 326426004301 Probable Catalytic site; other site 326426004302 Predicted membrane protein [Function unknown]; Region: COG3601 326426004303 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 326426004304 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326426004305 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 326426004306 Walker A/P-loop; other site 326426004307 ATP binding site [chemical binding]; other site 326426004308 Q-loop/lid; other site 326426004309 ABC transporter signature motif; other site 326426004310 Walker B; other site 326426004311 D-loop; other site 326426004312 H-loop/switch region; other site 326426004313 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326426004314 Walker A/P-loop; other site 326426004315 ATP binding site [chemical binding]; other site 326426004316 Q-loop/lid; other site 326426004317 ABC transporter signature motif; other site 326426004318 Walker B; other site 326426004319 D-loop; other site 326426004320 H-loop/switch region; other site 326426004321 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 326426004322 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 326426004323 Membrane protein of unknown function; Region: DUF360; pfam04020 326426004324 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 326426004325 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 326426004326 NAD binding site [chemical binding]; other site 326426004327 ligand binding site [chemical binding]; other site 326426004328 catalytic site [active] 326426004329 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426004330 putative substrate translocation pore; other site 326426004331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426004332 recombination factor protein RarA; Reviewed; Region: PRK13342 326426004333 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004334 Walker A motif; other site 326426004335 ATP binding site [chemical binding]; other site 326426004336 Walker B motif; other site 326426004337 arginine finger; other site 326426004338 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 326426004339 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426004340 ATP binding site [chemical binding]; other site 326426004341 putative Mg++ binding site [ion binding]; other site 326426004342 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426004343 nucleotide binding region [chemical binding]; other site 326426004344 ATP-binding site [chemical binding]; other site 326426004345 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 326426004346 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 326426004347 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326426004348 DNA-binding site [nucleotide binding]; DNA binding site 326426004349 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 326426004350 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426004351 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426004352 homodimer interface [polypeptide binding]; other site 326426004353 catalytic residue [active] 326426004354 LysE type translocator; Region: LysE; cl00565 326426004355 PAP2, bacterial acid phosphatase or class A non-specific acid phosphatases. These enzymes catalyze phosphomonoester hydrolysis, with optimal activity in low pH conditions. They are secreted into the periplasmic space, and their physiological role remains...; Region: PAP2_acid_phosphatase; cd03397 326426004356 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 326426004357 active site 326426004358 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426004359 dimer interface [polypeptide binding]; other site 326426004360 conserved gate region; other site 326426004361 putative PBP binding loops; other site 326426004362 ABC-ATPase subunit interface; other site 326426004363 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426004364 dimer interface [polypeptide binding]; other site 326426004365 conserved gate region; other site 326426004366 ABC-ATPase subunit interface; other site 326426004367 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326426004368 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326426004369 substrate binding pocket [chemical binding]; other site 326426004370 membrane-bound complex binding site; other site 326426004371 hinge residues; other site 326426004372 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326426004373 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326426004374 Walker A/P-loop; other site 326426004375 ATP binding site [chemical binding]; other site 326426004376 Q-loop/lid; other site 326426004377 ABC transporter signature motif; other site 326426004378 Walker B; other site 326426004379 D-loop; other site 326426004380 H-loop/switch region; other site 326426004381 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 326426004382 putative deacylase active site [active] 326426004383 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 326426004384 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 326426004385 dimer interface [polypeptide binding]; other site 326426004386 anticodon binding site; other site 326426004387 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326426004388 motif 1; other site 326426004389 dimer interface [polypeptide binding]; other site 326426004390 active site 326426004391 motif 2; other site 326426004392 GAD domain; Region: GAD; pfam02938 326426004393 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326426004394 active site 326426004395 motif 3; other site 326426004396 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 326426004397 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 326426004398 dimer interface [polypeptide binding]; other site 326426004399 active site 326426004400 motif 2; other site 326426004401 motif 3; other site 326426004402 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 326426004403 anticodon binding site; other site 326426004404 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 326426004405 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 326426004406 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 326426004407 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326426004408 active site 326426004409 metal binding site [ion binding]; metal-binding site 326426004410 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 326426004411 Creatinine amidohydrolase; Region: Creatininase; pfam02633 326426004412 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426004413 metabolite-proton symporter; Region: 2A0106; TIGR00883 326426004414 putative substrate translocation pore; other site 326426004415 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 326426004416 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326426004417 cytosine deaminase; Provisional; Region: PRK09230 326426004418 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 326426004419 active site 326426004420 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 326426004421 Clp amino terminal domain; Region: Clp_N; pfam02861 326426004422 Clp amino terminal domain; Region: Clp_N; pfam02861 326426004423 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004424 Walker A motif; other site 326426004425 ATP binding site [chemical binding]; other site 326426004426 Walker B motif; other site 326426004427 arginine finger; other site 326426004428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004429 Walker A motif; other site 326426004430 ATP binding site [chemical binding]; other site 326426004431 Walker B motif; other site 326426004432 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 326426004433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326426004434 Ligand Binding Site [chemical binding]; other site 326426004435 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326426004436 Ligand Binding Site [chemical binding]; other site 326426004437 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 326426004438 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326426004439 DNA-binding site [nucleotide binding]; DNA binding site 326426004440 RNA-binding motif; other site 326426004441 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326426004442 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 326426004443 dimerization interface [polypeptide binding]; other site 326426004444 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326426004445 dimer interface [polypeptide binding]; other site 326426004446 phosphorylation site [posttranslational modification] 326426004447 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426004448 ATP binding site [chemical binding]; other site 326426004449 Mg2+ binding site [ion binding]; other site 326426004450 G-X-G motif; other site 326426004451 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326426004452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426004453 active site 326426004454 phosphorylation site [posttranslational modification] 326426004455 intermolecular recognition site; other site 326426004456 dimerization interface [polypeptide binding]; other site 326426004457 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326426004458 DNA binding site [nucleotide binding] 326426004459 Repair protein; Region: Repair_PSII; cl01535 326426004460 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 326426004461 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 326426004462 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 326426004463 ring oligomerisation interface [polypeptide binding]; other site 326426004464 ATP/Mg binding site [chemical binding]; other site 326426004465 stacking interactions; other site 326426004466 hinge regions; other site 326426004467 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 326426004468 DNA-binding site [nucleotide binding]; DNA binding site 326426004469 RNA-binding motif; other site 326426004470 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 326426004471 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 326426004472 ligand binding site [chemical binding]; other site 326426004473 active site 326426004474 UGI interface [polypeptide binding]; other site 326426004475 catalytic site [active] 326426004476 MoxR-like ATPases [General function prediction only]; Region: COG0714 326426004477 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 326426004478 Protein of unknown function DUF58; Region: DUF58; pfam01882 326426004479 von Willebrand factor type A domain; Region: VWA_2; pfam13519 326426004480 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 326426004481 metal ion-dependent adhesion site (MIDAS); other site 326426004482 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 326426004483 adenylosuccinate lyase; Provisional; Region: PRK09285 326426004484 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 326426004485 tetramer interface [polypeptide binding]; other site 326426004486 active site 326426004487 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 326426004488 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 326426004489 IHF dimer interface [polypeptide binding]; other site 326426004490 IHF - DNA interface [nucleotide binding]; other site 326426004491 Pup-ligase protein; Region: Pup_ligase; cl15463 326426004492 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 326426004493 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 326426004494 active site 326426004495 Pup-ligase protein; Region: Pup_ligase; cl15463 326426004496 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 326426004497 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 326426004498 substrate binding site [chemical binding]; other site 326426004499 hexamer interface [polypeptide binding]; other site 326426004500 metal binding site [ion binding]; metal-binding site 326426004501 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 326426004502 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 326426004503 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 326426004504 active site 326426004505 P-loop; other site 326426004506 phosphorylation site [posttranslational modification] 326426004507 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 326426004508 active site 326426004509 phosphorylation site [posttranslational modification] 326426004510 Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359 326426004511 active site 326426004512 phosphorylation site [posttranslational modification] 326426004513 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 326426004514 HTH domain; Region: HTH_11; pfam08279 326426004515 PRD domain; Region: PRD; pfam00874 326426004516 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 326426004517 active site 326426004518 P-loop; other site 326426004519 phosphorylation site [posttranslational modification] 326426004520 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 326426004521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426004522 proteasome ATPase; Region: pup_AAA; TIGR03689 326426004523 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004524 Walker A motif; other site 326426004525 ATP binding site [chemical binding]; other site 326426004526 Walker B motif; other site 326426004527 arginine finger; other site 326426004528 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 326426004529 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 326426004530 phosphoserine phosphatase SerB; Region: serB; TIGR00338 326426004531 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426004532 motif II; other site 326426004533 primosome assembly protein PriA; Provisional; Region: PRK14873 326426004534 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 326426004535 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 326426004536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426004537 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 326426004538 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 326426004539 putative active site [active] 326426004540 substrate binding site [chemical binding]; other site 326426004541 putative cosubstrate binding site; other site 326426004542 catalytic site [active] 326426004543 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 326426004544 substrate binding site [chemical binding]; other site 326426004545 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 326426004546 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 326426004547 S-adenosylmethionine synthetase; Validated; Region: PRK05250 326426004548 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 326426004549 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 326426004550 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 326426004551 Fic family protein [Function unknown]; Region: COG3177 326426004552 Fic/DOC family; Region: Fic; pfam02661 326426004553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 326426004554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426004555 Integrase core domain; Region: rve; pfam00665 326426004556 transposase/IS protein; Provisional; Region: PRK09183 326426004557 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004558 Walker A motif; other site 326426004559 ATP binding site [chemical binding]; other site 326426004560 Walker B motif; other site 326426004561 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426004562 Integrase core domain; Region: rve; pfam00665 326426004563 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 326426004564 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 326426004565 CRISPR-associated protein Cas4; Region: cas4; TIGR00372 326426004566 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 326426004567 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 326426004568 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 326426004569 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 326426004570 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 326426004571 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 326426004572 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 326426004573 transposase/IS protein; Provisional; Region: PRK09183 326426004574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004575 Walker A motif; other site 326426004576 ATP binding site [chemical binding]; other site 326426004577 Walker B motif; other site 326426004578 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426004579 Integrase core domain; Region: rve; pfam00665 326426004580 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 326426004581 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 326426004582 HIGH motif; other site 326426004583 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 326426004584 active site 326426004585 KMSKS motif; other site 326426004586 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 326426004587 tRNA binding surface [nucleotide binding]; other site 326426004588 anticodon binding site; other site 326426004589 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326426004590 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 326426004591 substrate binding site [chemical binding]; other site 326426004592 dimer interface [polypeptide binding]; other site 326426004593 ATP binding site [chemical binding]; other site 326426004594 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 326426004595 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 326426004596 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 326426004597 ligand binding site [chemical binding]; other site 326426004598 dimerization interface [polypeptide binding]; other site 326426004599 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326426004600 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 326426004601 TM-ABC transporter signature motif; other site 326426004602 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 326426004603 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 326426004604 Walker A/P-loop; other site 326426004605 ATP binding site [chemical binding]; other site 326426004606 Q-loop/lid; other site 326426004607 ABC transporter signature motif; other site 326426004608 Walker B; other site 326426004609 D-loop; other site 326426004610 H-loop/switch region; other site 326426004611 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 326426004612 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426004613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426004614 DNA binding site [nucleotide binding] 326426004615 domain linker motif; other site 326426004616 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326426004617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426004618 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 326426004619 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326426004620 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 326426004621 substrate binding site [chemical binding]; other site 326426004622 dimer interface [polypeptide binding]; other site 326426004623 ATP binding site [chemical binding]; other site 326426004624 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 326426004625 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 326426004626 dimer interface [polypeptide binding]; other site 326426004627 active site 326426004628 metal binding site [ion binding]; metal-binding site 326426004629 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 326426004630 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426004631 motif II; other site 326426004632 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 326426004633 active site 326426004634 tetramer interface [polypeptide binding]; other site 326426004635 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 326426004636 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326426004637 substrate binding site [chemical binding]; other site 326426004638 ATP binding site [chemical binding]; other site 326426004639 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 326426004640 active site 326426004641 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326426004642 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326426004643 Walker A/P-loop; other site 326426004644 ATP binding site [chemical binding]; other site 326426004645 Q-loop/lid; other site 326426004646 ABC transporter signature motif; other site 326426004647 Walker B; other site 326426004648 D-loop; other site 326426004649 H-loop/switch region; other site 326426004650 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 326426004651 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 326426004652 Walker A/P-loop; other site 326426004653 ATP binding site [chemical binding]; other site 326426004654 Q-loop/lid; other site 326426004655 ABC transporter signature motif; other site 326426004656 Walker B; other site 326426004657 D-loop; other site 326426004658 H-loop/switch region; other site 326426004659 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 326426004660 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426004661 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426004662 DNA binding site [nucleotide binding] 326426004663 domain linker motif; other site 326426004664 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426004665 dimerization interface [polypeptide binding]; other site 326426004666 ligand binding site [chemical binding]; other site 326426004667 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326426004668 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 326426004669 substrate binding site [chemical binding]; other site 326426004670 dimer interface [polypeptide binding]; other site 326426004671 ATP binding site [chemical binding]; other site 326426004672 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 326426004673 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326426004674 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 326426004675 Walker A/P-loop; other site 326426004676 ATP binding site [chemical binding]; other site 326426004677 Q-loop/lid; other site 326426004678 ABC transporter signature motif; other site 326426004679 Walker B; other site 326426004680 D-loop; other site 326426004681 H-loop/switch region; other site 326426004682 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326426004683 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326426004684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426004685 Walker A/P-loop; other site 326426004686 ATP binding site [chemical binding]; other site 326426004687 Q-loop/lid; other site 326426004688 ABC transporter signature motif; other site 326426004689 Walker B; other site 326426004690 D-loop; other site 326426004691 H-loop/switch region; other site 326426004692 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326426004693 MarR family; Region: MarR_2; pfam12802 326426004694 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 326426004695 nucleotidyltransferase substrate binding protein, HI0074 family; Region: HI0074; TIGR01987 326426004696 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 326426004697 active site 326426004698 NTP binding site [chemical binding]; other site 326426004699 metal binding triad [ion binding]; metal-binding site 326426004700 antibiotic binding site [chemical binding]; other site 326426004701 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 326426004702 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 326426004703 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 326426004704 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326426004705 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326426004706 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 326426004707 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 326426004708 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 326426004709 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 326426004710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 326426004711 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 326426004712 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 326426004713 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 326426004714 anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804 326426004715 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 326426004716 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 326426004717 ATP cone domain; Region: ATP-cone; pfam03477 326426004718 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 326426004719 Class III ribonucleotide reductase; Region: RNR_III; cd01675 326426004720 active site 326426004721 Zn binding site [ion binding]; other site 326426004722 glycine loop; other site 326426004723 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 326426004724 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 326426004725 generic binding surface II; other site 326426004726 generic binding surface I; other site 326426004727 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 326426004728 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 326426004729 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 326426004730 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 326426004731 acyl-activating enzyme (AAE) consensus motif; other site 326426004732 putative AMP binding site [chemical binding]; other site 326426004733 putative active site [active] 326426004734 putative CoA binding site [chemical binding]; other site 326426004735 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 326426004736 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 326426004737 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 326426004738 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 326426004739 putative catalytic site [active] 326426004740 putative metal binding site [ion binding]; other site 326426004741 putative phosphate binding site [ion binding]; other site 326426004742 exopolyphosphatase; Region: exo_poly_only; TIGR03706 326426004743 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 326426004744 aminotransferase; Validated; Region: PRK07337 326426004745 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426004746 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426004747 homodimer interface [polypeptide binding]; other site 326426004748 catalytic residue [active] 326426004749 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 326426004750 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 326426004751 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 326426004752 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 326426004753 additional DNA contacts [nucleotide binding]; other site 326426004754 mismatch recognition site; other site 326426004755 active site 326426004756 zinc binding site [ion binding]; other site 326426004757 DNA intercalation site [nucleotide binding]; other site 326426004758 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 326426004759 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326426004760 Coenzyme A binding pocket [chemical binding]; other site 326426004761 SWIM zinc finger; Region: SWIM; pfam04434 326426004762 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 326426004763 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 326426004764 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426004765 ATP binding site [chemical binding]; other site 326426004766 putative Mg++ binding site [ion binding]; other site 326426004767 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426004768 nucleotide binding region [chemical binding]; other site 326426004769 ATP-binding site [chemical binding]; other site 326426004770 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 326426004771 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 326426004772 putative trimer interface [polypeptide binding]; other site 326426004773 putative CoA binding site [chemical binding]; other site 326426004774 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 326426004775 Citrate synthase; Region: Citrate_synt; pfam00285 326426004776 oxalacetate binding site [chemical binding]; other site 326426004777 citrylCoA binding site [chemical binding]; other site 326426004778 coenzyme A binding site [chemical binding]; other site 326426004779 catalytic triad [active] 326426004780 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 326426004781 active site 326426004782 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 326426004783 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 326426004784 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 326426004785 active site 326426004786 Zn binding site [ion binding]; other site 326426004787 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 326426004788 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 326426004789 dimer interface [polypeptide binding]; other site 326426004790 ssDNA binding site [nucleotide binding]; other site 326426004791 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326426004792 prolyl-tRNA synthetase; Provisional; Region: PRK09194 326426004793 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 326426004794 dimer interface [polypeptide binding]; other site 326426004795 motif 1; other site 326426004796 active site 326426004797 motif 2; other site 326426004798 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 326426004799 putative deacylase active site [active] 326426004800 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326426004801 active site 326426004802 motif 3; other site 326426004803 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 326426004804 anticodon binding site; other site 326426004805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004806 PIF1-like helicase; Region: PIF1; pfam05970 326426004807 Walker A motif; other site 326426004808 ATP binding site [chemical binding]; other site 326426004809 Walker B motif; other site 326426004810 arginine finger; other site 326426004811 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 326426004812 catalytic site [active] 326426004813 putative active site [active] 326426004814 putative substrate binding site [chemical binding]; other site 326426004815 dimer interface [polypeptide binding]; other site 326426004816 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 326426004817 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326426004818 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 326426004819 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 326426004820 active site 326426004821 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 326426004822 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 326426004823 Mg++ binding site [ion binding]; other site 326426004824 putative catalytic motif [active] 326426004825 substrate binding site [chemical binding]; other site 326426004826 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 326426004827 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 326426004828 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 326426004829 Walker A/P-loop; other site 326426004830 ATP binding site [chemical binding]; other site 326426004831 Q-loop/lid; other site 326426004832 ABC transporter signature motif; other site 326426004833 Walker B; other site 326426004834 D-loop; other site 326426004835 H-loop/switch region; other site 326426004836 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 326426004837 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 326426004838 Walker A/P-loop; other site 326426004839 ATP binding site [chemical binding]; other site 326426004840 Q-loop/lid; other site 326426004841 ABC transporter signature motif; other site 326426004842 Walker B; other site 326426004843 D-loop; other site 326426004844 H-loop/switch region; other site 326426004845 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 326426004846 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 326426004847 TM-ABC transporter signature motif; other site 326426004848 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326426004849 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 326426004850 TM-ABC transporter signature motif; other site 326426004851 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 326426004852 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 326426004853 putative ligand binding site [chemical binding]; other site 326426004854 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 326426004855 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426004856 S-adenosylmethionine binding site [chemical binding]; other site 326426004857 peptide chain release factor 1; Validated; Region: prfA; PRK00591 326426004858 This domain is found in peptide chain release factors; Region: PCRF; smart00937 326426004859 RF-1 domain; Region: RF-1; pfam00472 326426004860 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 326426004861 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326426004862 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 326426004863 active site 326426004864 catalytic residues [active] 326426004865 metal binding site [ion binding]; metal-binding site 326426004866 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 326426004867 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 326426004868 active site 326426004869 catalytic tetrad [active] 326426004870 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326426004871 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 326426004872 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 326426004873 nucleotide binding site [chemical binding]; other site 326426004874 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 326426004875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426004876 putative substrate translocation pore; other site 326426004877 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 326426004878 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426004879 Walker A/P-loop; other site 326426004880 ATP binding site [chemical binding]; other site 326426004881 Q-loop/lid; other site 326426004882 ABC transporter signature motif; other site 326426004883 Walker B; other site 326426004884 D-loop; other site 326426004885 H-loop/switch region; other site 326426004886 ABC transporter; Region: ABC_tran_2; pfam12848 326426004887 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326426004888 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 326426004889 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 326426004890 active site 326426004891 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 326426004892 catalytic triad [active] 326426004893 dimer interface [polypeptide binding]; other site 326426004894 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 326426004895 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 326426004896 homooctamer interface [polypeptide binding]; other site 326426004897 active site 326426004898 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 326426004899 catalytic center binding site [active] 326426004900 ATP binding site [chemical binding]; other site 326426004901 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 326426004902 catalytic center binding site [active] 326426004903 ATP binding site [chemical binding]; other site 326426004904 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 326426004905 dihydropteroate synthase; Region: DHPS; TIGR01496 326426004906 substrate binding pocket [chemical binding]; other site 326426004907 dimer interface [polypeptide binding]; other site 326426004908 inhibitor binding site; inhibition site 326426004909 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 326426004910 GTP cyclohydrolase I; Provisional; Region: PLN03044 326426004911 homodecamer interface [polypeptide binding]; other site 326426004912 active site 326426004913 putative catalytic site residues [active] 326426004914 zinc binding site [ion binding]; other site 326426004915 GTP-CH-I/GFRP interaction surface; other site 326426004916 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 326426004917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004918 Walker A motif; other site 326426004919 ATP binding site [chemical binding]; other site 326426004920 Walker B motif; other site 326426004921 arginine finger; other site 326426004922 Peptidase family M41; Region: Peptidase_M41; pfam01434 326426004923 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326426004924 active site 326426004925 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 326426004926 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 326426004927 Ligand Binding Site [chemical binding]; other site 326426004928 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 326426004929 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 326426004930 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 326426004931 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 326426004932 Walker A/P-loop; other site 326426004933 ATP binding site [chemical binding]; other site 326426004934 Q-loop/lid; other site 326426004935 ABC transporter signature motif; other site 326426004936 Walker B; other site 326426004937 D-loop; other site 326426004938 H-loop/switch region; other site 326426004939 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 326426004940 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 326426004941 DXD motif; other site 326426004942 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 326426004943 Domain of unknown function DUF20; Region: UPF0118; pfam01594 326426004944 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 326426004945 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326426004946 active site 326426004947 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 326426004948 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 326426004949 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 326426004950 dimer interface [polypeptide binding]; other site 326426004951 active site 326426004952 metal binding site [ion binding]; metal-binding site 326426004953 Mycolic acid cyclopropane synthetase; Region: CMAS; pfam02353 326426004954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426004955 S-adenosylmethionine binding site [chemical binding]; other site 326426004956 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 326426004957 Helix-turn-helix domain; Region: HTH_36; pfam13730 326426004958 Transcription factor WhiB; Region: Whib; pfam02467 326426004959 transposase/IS protein; Provisional; Region: PRK09183 326426004960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426004961 Walker A motif; other site 326426004962 ATP binding site [chemical binding]; other site 326426004963 Walker B motif; other site 326426004964 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426004965 Integrase core domain; Region: rve; pfam00665 326426004966 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326426004967 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326426004968 P-loop; other site 326426004969 Magnesium ion binding site [ion binding]; other site 326426004970 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 326426004971 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426004972 Walker A/P-loop; other site 326426004973 ATP binding site [chemical binding]; other site 326426004974 Q-loop/lid; other site 326426004975 ABC transporter signature motif; other site 326426004976 Walker B; other site 326426004977 D-loop; other site 326426004978 H-loop/switch region; other site 326426004979 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 326426004980 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 326426004981 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 326426004982 Coenzyme A binding pocket [chemical binding]; other site 326426004983 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 326426004984 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426004985 motif II; other site 326426004986 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 326426004987 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 326426004988 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 326426004989 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 326426004990 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 326426004991 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 326426004992 active site 326426004993 Helix-turn-helix domain; Region: HTH_17; pfam12728 326426004994 PIN domain; Region: PIN_3; pfam13470 326426004995 Transposase, Mutator family; Region: Transposase_mut; pfam00872 326426004996 MULE transposase domain; Region: MULE; pfam10551 326426004997 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 326426004998 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326426004999 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326426005000 catalytic residue [active] 326426005001 Surface antigen [General function prediction only]; Region: COG3942 326426005002 CHAP domain; Region: CHAP; pfam05257 326426005003 DNA protecting protein DprA; Region: dprA; TIGR00732 326426005004 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 326426005005 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 326426005006 active site 326426005007 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 326426005008 Part of AAA domain; Region: AAA_19; pfam13245 326426005009 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 326426005010 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426005011 AAA domain; Region: AAA_21; pfam13304 326426005012 Walker A/P-loop; other site 326426005013 ATP binding site [chemical binding]; other site 326426005014 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426005015 Q-loop/lid; other site 326426005016 ABC transporter signature motif; other site 326426005017 Walker B; other site 326426005018 D-loop; other site 326426005019 H-loop/switch region; other site 326426005020 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 326426005021 putative active site [active] 326426005022 putative metal-binding site [ion binding]; other site 326426005023 AAA-like domain; Region: AAA_10; pfam12846 326426005024 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 326426005025 Antirestriction protein (ArdA); Region: ArdA; cl01953 326426005026 transposase/IS protein; Provisional; Region: PRK09183 326426005027 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426005028 Walker A motif; other site 326426005029 ATP binding site [chemical binding]; other site 326426005030 Walker B motif; other site 326426005031 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426005032 Integrase core domain; Region: rve; pfam00665 326426005033 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 326426005034 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 326426005035 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 326426005036 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 326426005037 ParB-like nuclease domain; Region: ParBc; pfam02195 326426005038 Domain of unknown function (DUF4192); Region: DUF4192; pfam13830 326426005039 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 326426005040 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 326426005041 active site 326426005042 Int/Topo IB signature motif; other site 326426005043 DNA binding site [nucleotide binding] 326426005044 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 326426005045 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 326426005046 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 326426005047 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 326426005048 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 326426005049 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 326426005050 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 326426005051 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426005052 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426005053 DNA binding site [nucleotide binding] 326426005054 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 326426005055 putative ligand binding site [chemical binding]; other site 326426005056 putative dimerization interface [polypeptide binding]; other site 326426005057 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426005058 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426005059 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326426005060 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426005061 Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838 326426005062 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 326426005063 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 326426005064 putative active site [active] 326426005065 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326426005066 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426005067 FtsX-like permease family; Region: FtsX; pfam02687 326426005068 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426005069 FtsX-like permease family; Region: FtsX; pfam02687 326426005070 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426005071 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426005072 Walker A/P-loop; other site 326426005073 ATP binding site [chemical binding]; other site 326426005074 Q-loop/lid; other site 326426005075 ABC transporter signature motif; other site 326426005076 Walker B; other site 326426005077 D-loop; other site 326426005078 H-loop/switch region; other site 326426005079 Low molecular weight phosphatase family; Region: LMWPc; cd00115 326426005080 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 326426005081 active site 326426005082 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 326426005083 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 326426005084 folate binding site [chemical binding]; other site 326426005085 NADP+ binding site [chemical binding]; other site 326426005086 thymidylate synthase; Reviewed; Region: thyA; PRK01827 326426005087 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 326426005088 dimerization interface [polypeptide binding]; other site 326426005089 active site 326426005090 OsmC-like protein; Region: OsmC; pfam02566 326426005091 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326426005092 Ligand Binding Site [chemical binding]; other site 326426005093 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 326426005094 Ligand Binding Site [chemical binding]; other site 326426005095 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326426005096 NlpC/P60 family; Region: NLPC_P60; pfam00877 326426005097 NlpC/P60 family; Region: NLPC_P60; cl17555 326426005098 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 326426005099 CHAP domain; Region: CHAP; pfam05257 326426005100 phosphoserine aminotransferase; Provisional; Region: PRK03080 326426005101 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 326426005102 catalytic residue [active] 326426005103 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 326426005104 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426005105 ATP binding site [chemical binding]; other site 326426005106 Mg2+ binding site [ion binding]; other site 326426005107 G-X-G motif; other site 326426005108 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 326426005109 PhoU domain; Region: PhoU; pfam01895 326426005110 PhoU domain; Region: PhoU; pfam01895 326426005111 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426005112 catalytic core [active] 326426005113 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 326426005114 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 326426005115 UbiA prenyltransferase family; Region: UbiA; pfam01040 326426005116 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 326426005117 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 326426005118 dimer interface [polypeptide binding]; other site 326426005119 putative anticodon binding site; other site 326426005120 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 326426005121 motif 1; other site 326426005122 dimer interface [polypeptide binding]; other site 326426005123 active site 326426005124 motif 2; other site 326426005125 motif 3; other site 326426005126 MFS transport protein AraJ; Provisional; Region: PRK10091 326426005127 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426005128 putative substrate translocation pore; other site 326426005129 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326426005130 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 326426005131 binding surface 326426005132 TPR motif; other site 326426005133 Tetratricopeptide repeat; Region: TPR_12; pfam13424 326426005134 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 326426005135 Protein of unknown function (DUF4125); Region: DUF4125; pfam13526 326426005136 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 326426005137 PspC domain; Region: PspC; pfam04024 326426005138 PspC domain; Region: PspC; pfam04024 326426005139 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 326426005140 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426005141 ATP binding site [chemical binding]; other site 326426005142 Mg2+ binding site [ion binding]; other site 326426005143 G-X-G motif; other site 326426005144 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 326426005145 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426005146 active site 326426005147 phosphorylation site [posttranslational modification] 326426005148 intermolecular recognition site; other site 326426005149 dimerization interface [polypeptide binding]; other site 326426005150 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 326426005151 DNA binding residues [nucleotide binding] 326426005152 dimerization interface [polypeptide binding]; other site 326426005153 UDP-glucose 4-epimerase; Region: PLN02240 326426005154 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 326426005155 NAD binding site [chemical binding]; other site 326426005156 homodimer interface [polypeptide binding]; other site 326426005157 active site 326426005158 substrate binding site [chemical binding]; other site 326426005159 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 326426005160 Phosphotransferase enzyme family; Region: APH; pfam01636 326426005161 active site 326426005162 substrate binding site [chemical binding]; other site 326426005163 ATP binding site [chemical binding]; other site 326426005164 1,3-beta-galactosyl-N-acetylhexosamine phosphorylase; Region: TIGR02336 326426005165 Lacto-N-biose phosphorylase; Region: Lact_bio_phlase; pfam09508 326426005166 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426005167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005168 dimer interface [polypeptide binding]; other site 326426005169 conserved gate region; other site 326426005170 putative PBP binding loops; other site 326426005171 ABC-ATPase subunit interface; other site 326426005172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005173 dimer interface [polypeptide binding]; other site 326426005174 conserved gate region; other site 326426005175 ABC-ATPase subunit interface; other site 326426005176 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426005177 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426005178 seryl-tRNA synthetase; Provisional; Region: PRK05431 326426005179 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 326426005180 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 326426005181 dimer interface [polypeptide binding]; other site 326426005182 active site 326426005183 motif 1; other site 326426005184 motif 2; other site 326426005185 motif 3; other site 326426005186 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 326426005187 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 326426005188 transcriptional antiterminator BglG; Provisional; Region: PRK09772 326426005189 CAT RNA binding domain; Region: CAT_RBD; smart01061 326426005190 PRD domain; Region: PRD; pfam00874 326426005191 PRD domain; Region: PRD; pfam00874 326426005192 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 326426005193 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 326426005194 active site turn [active] 326426005195 phosphorylation site [posttranslational modification] 326426005196 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326426005197 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 326426005198 HPr interaction site; other site 326426005199 glycerol kinase (GK) interaction site [polypeptide binding]; other site 326426005200 active site 326426005201 phosphorylation site [posttranslational modification] 326426005202 phosphoglucomutase; Validated; Region: PRK07564 326426005203 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 326426005204 active site 326426005205 substrate binding site [chemical binding]; other site 326426005206 metal binding site [ion binding]; metal-binding site 326426005207 Transcriptional regulator; Region: Rrf2; pfam02082 326426005208 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 326426005209 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326426005210 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326426005211 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 326426005212 RNA/DNA hybrid binding site [nucleotide binding]; other site 326426005213 active site 326426005214 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 326426005215 tetramer (dimer of dimers) interface [polypeptide binding]; other site 326426005216 active site 326426005217 dimer interface [polypeptide binding]; other site 326426005218 DNA repair protein RadA; Provisional; Region: PRK11823 326426005219 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 326426005220 Walker A motif; other site 326426005221 ATP binding site [chemical binding]; other site 326426005222 Walker B motif; other site 326426005223 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 326426005224 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 326426005225 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 326426005226 active site 326426005227 Riboflavin kinase; Region: Flavokinase; smart00904 326426005228 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 326426005229 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 326426005230 RNA binding site [nucleotide binding]; other site 326426005231 active site 326426005232 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 326426005233 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 326426005234 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 326426005235 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 326426005236 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 326426005237 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 326426005238 G1 box; other site 326426005239 putative GEF interaction site [polypeptide binding]; other site 326426005240 GTP/Mg2+ binding site [chemical binding]; other site 326426005241 Switch I region; other site 326426005242 G2 box; other site 326426005243 G3 box; other site 326426005244 Switch II region; other site 326426005245 G4 box; other site 326426005246 G5 box; other site 326426005247 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 326426005248 Translation-initiation factor 2; Region: IF-2; pfam11987 326426005249 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 326426005250 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 326426005251 NusA N-terminal domain; Region: NusA_N; pfam08529 326426005252 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 326426005253 RNA binding site [nucleotide binding]; other site 326426005254 homodimer interface [polypeptide binding]; other site 326426005255 NusA-like KH domain; Region: KH_5; pfam13184 326426005256 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 326426005257 G-X-X-G motif; other site 326426005258 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 326426005259 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 326426005260 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 326426005261 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 326426005262 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 326426005263 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 326426005264 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 326426005265 dimerization interface 3.5A [polypeptide binding]; other site 326426005266 active site 326426005267 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 326426005268 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 326426005269 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 326426005270 alphaNTD homodimer interface [polypeptide binding]; other site 326426005271 alphaNTD - beta interaction site [polypeptide binding]; other site 326426005272 alphaNTD - beta' interaction site [polypeptide binding]; other site 326426005273 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 326426005274 30S ribosomal protein S11; Validated; Region: PRK05309 326426005275 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 326426005276 30S ribosomal protein S13; Region: bact_S13; TIGR03631 326426005277 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 326426005278 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 326426005279 rRNA binding site [nucleotide binding]; other site 326426005280 predicted 30S ribosome binding site; other site 326426005281 adenylate kinase; Reviewed; Region: adk; PRK00279 326426005282 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 326426005283 AMP-binding site [chemical binding]; other site 326426005284 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 326426005285 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 326426005286 SecY translocase; Region: SecY; pfam00344 326426005287 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 326426005288 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 326426005289 23S rRNA binding site [nucleotide binding]; other site 326426005290 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 326426005291 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 326426005292 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 326426005293 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 326426005294 23S rRNA interface [nucleotide binding]; other site 326426005295 L21e interface [polypeptide binding]; other site 326426005296 5S rRNA interface [nucleotide binding]; other site 326426005297 L27 interface [polypeptide binding]; other site 326426005298 L5 interface [polypeptide binding]; other site 326426005299 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 326426005300 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 326426005301 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 326426005302 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 326426005303 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 326426005304 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 326426005305 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 326426005306 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 326426005307 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 326426005308 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 326426005309 RNA binding site [nucleotide binding]; other site 326426005310 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 326426005311 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 326426005312 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 326426005313 23S rRNA interface [nucleotide binding]; other site 326426005314 putative translocon interaction site; other site 326426005315 signal recognition particle (SRP54) interaction site; other site 326426005316 L23 interface [polypeptide binding]; other site 326426005317 trigger factor interaction site; other site 326426005318 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 326426005319 23S rRNA interface [nucleotide binding]; other site 326426005320 5S rRNA interface [nucleotide binding]; other site 326426005321 putative antibiotic binding site [chemical binding]; other site 326426005322 L25 interface [polypeptide binding]; other site 326426005323 L27 interface [polypeptide binding]; other site 326426005324 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 326426005325 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 326426005326 G-X-X-G motif; other site 326426005327 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 326426005328 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 326426005329 putative translocon binding site; other site 326426005330 protein-rRNA interface [nucleotide binding]; other site 326426005331 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 326426005332 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 326426005333 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 326426005334 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 326426005335 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 326426005336 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 326426005337 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 326426005338 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 326426005339 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 326426005340 YwiC-like protein; Region: YwiC; pfam14256 326426005341 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 326426005342 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 326426005343 putative catalytic cysteine [active] 326426005344 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 326426005345 putative active site [active] 326426005346 metal binding site [ion binding]; metal-binding site 326426005347 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326426005348 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 326426005349 non-specific DNA interactions [nucleotide binding]; other site 326426005350 DNA binding site [nucleotide binding] 326426005351 sequence specific DNA binding site [nucleotide binding]; other site 326426005352 putative cAMP binding site [chemical binding]; other site 326426005353 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426005354 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326426005355 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326426005356 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 326426005357 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 326426005358 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 326426005359 active site 326426005360 catalytic site [active] 326426005361 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 326426005362 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 326426005363 23S rRNA interface [nucleotide binding]; other site 326426005364 L3 interface [polypeptide binding]; other site 326426005365 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 326426005366 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 326426005367 Uncharacterized conserved protein [Function unknown]; Region: COG1739 326426005368 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 326426005369 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 326426005370 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 326426005371 dimerization interface [polypeptide binding]; other site 326426005372 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 326426005373 NAD binding site [chemical binding]; other site 326426005374 ligand binding site [chemical binding]; other site 326426005375 catalytic site [active] 326426005376 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 326426005377 beta-galactosidase; Region: BGL; TIGR03356 326426005378 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426005379 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005380 dimer interface [polypeptide binding]; other site 326426005381 conserved gate region; other site 326426005382 putative PBP binding loops; other site 326426005383 ABC-ATPase subunit interface; other site 326426005384 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 326426005385 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005386 dimer interface [polypeptide binding]; other site 326426005387 conserved gate region; other site 326426005388 putative PBP binding loops; other site 326426005389 ABC-ATPase subunit interface; other site 326426005390 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426005391 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426005392 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426005393 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426005394 DNA binding site [nucleotide binding] 326426005395 domain linker motif; other site 326426005396 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426005397 dimerization interface [polypeptide binding]; other site 326426005398 ligand binding site [chemical binding]; other site 326426005399 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 326426005400 active site 326426005401 DNA polymerase IV; Validated; Region: PRK02406 326426005402 DNA binding site [nucleotide binding] 326426005403 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 326426005404 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426005405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426005406 homodimer interface [polypeptide binding]; other site 326426005407 catalytic residue [active] 326426005408 Ferredoxin [Energy production and conversion]; Region: COG1146 326426005409 4Fe-4S binding domain; Region: Fer4; pfam00037 326426005410 amino acid transporter; Region: 2A0306; TIGR00909 326426005411 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 326426005412 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 326426005413 FAD binding domain; Region: FAD_binding_4; pfam01565 326426005414 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 326426005415 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 326426005416 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 326426005417 oligomerisation interface [polypeptide binding]; other site 326426005418 mobile loop; other site 326426005419 roof hairpin; other site 326426005420 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 326426005421 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 326426005422 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326426005423 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 326426005424 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 326426005425 Part of AAA domain; Region: AAA_19; pfam13245 326426005426 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 326426005427 phosphopeptide binding site; other site 326426005428 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 326426005429 peripheral dimer interface [polypeptide binding]; other site 326426005430 core dimer interface [polypeptide binding]; other site 326426005431 L10 interface [polypeptide binding]; other site 326426005432 L11 interface [polypeptide binding]; other site 326426005433 putative EF-Tu interaction site [polypeptide binding]; other site 326426005434 putative EF-G interaction site [polypeptide binding]; other site 326426005435 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 326426005436 23S rRNA interface [nucleotide binding]; other site 326426005437 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 326426005438 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 326426005439 Sulfate transporter family; Region: Sulfate_transp; pfam00916 326426005440 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 326426005441 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 326426005442 Walker A/P-loop; other site 326426005443 ATP binding site [chemical binding]; other site 326426005444 Q-loop/lid; other site 326426005445 ABC transporter signature motif; other site 326426005446 Walker B; other site 326426005447 D-loop; other site 326426005448 H-loop/switch region; other site 326426005449 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 326426005450 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005451 dimer interface [polypeptide binding]; other site 326426005452 conserved gate region; other site 326426005453 putative PBP binding loops; other site 326426005454 ABC-ATPase subunit interface; other site 326426005455 phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138 326426005456 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005457 dimer interface [polypeptide binding]; other site 326426005458 conserved gate region; other site 326426005459 putative PBP binding loops; other site 326426005460 ABC-ATPase subunit interface; other site 326426005461 PBP superfamily domain; Region: PBP_like_2; cl17296 326426005462 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 326426005463 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426005464 active site 326426005465 phosphorylation site [posttranslational modification] 326426005466 intermolecular recognition site; other site 326426005467 dimerization interface [polypeptide binding]; other site 326426005468 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 326426005469 DNA binding site [nucleotide binding] 326426005470 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 326426005471 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 326426005472 dimer interface [polypeptide binding]; other site 326426005473 phosphorylation site [posttranslational modification] 326426005474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426005475 ATP binding site [chemical binding]; other site 326426005476 Mg2+ binding site [ion binding]; other site 326426005477 G-X-G motif; other site 326426005478 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426005479 metabolite-proton symporter; Region: 2A0106; TIGR00883 326426005480 putative substrate translocation pore; other site 326426005481 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 326426005482 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 326426005483 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 326426005484 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 326426005485 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 326426005486 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 326426005487 Domain of unknown function (DUF386); Region: DUF386; cl01047 326426005488 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 326426005489 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 326426005490 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 326426005491 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 326426005492 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 326426005493 beta-phosphoglucomutase; Region: bPGM; TIGR01990 326426005494 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426005495 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 326426005496 EamA-like transporter family; Region: EamA; pfam00892 326426005497 EamA-like transporter family; Region: EamA; pfam00892 326426005498 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 326426005499 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 326426005500 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 326426005501 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 326426005502 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426005503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005504 dimer interface [polypeptide binding]; other site 326426005505 conserved gate region; other site 326426005506 putative PBP binding loops; other site 326426005507 ABC-ATPase subunit interface; other site 326426005508 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 326426005509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005510 dimer interface [polypeptide binding]; other site 326426005511 conserved gate region; other site 326426005512 putative PBP binding loops; other site 326426005513 ABC-ATPase subunit interface; other site 326426005514 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426005515 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 326426005516 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426005517 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426005518 DNA binding site [nucleotide binding] 326426005519 domain linker motif; other site 326426005520 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426005521 dimerization interface [polypeptide binding]; other site 326426005522 ligand binding site [chemical binding]; other site 326426005523 MarC family integral membrane protein; Region: MarC; cl00919 326426005524 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 326426005525 trimer interface [polypeptide binding]; other site 326426005526 active site 326426005527 G bulge; other site 326426005528 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 326426005529 trimer interface [polypeptide binding]; other site 326426005530 active site 326426005531 G bulge; other site 326426005532 DivIVA protein; Region: DivIVA; pfam05103 326426005533 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 326426005534 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 326426005535 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 326426005536 putative substrate binding pocket [chemical binding]; other site 326426005537 AC domain interface; other site 326426005538 catalytic triad [active] 326426005539 AB domain interface; other site 326426005540 interchain disulfide; other site 326426005541 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 326426005542 substrate binding site; other site 326426005543 dimer interface; other site 326426005544 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 326426005545 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 326426005546 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 326426005547 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 326426005548 Peptidase family U32; Region: Peptidase_U32; pfam01136 326426005549 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 326426005550 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 326426005551 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 326426005552 S-adenosylmethionine binding site [chemical binding]; other site 326426005553 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 326426005554 ssDNA binding site; other site 326426005555 generic binding surface II; other site 326426005556 DEAD-like helicases superfamily; Region: DEXDc; smart00487 326426005557 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 326426005558 ATP binding site [chemical binding]; other site 326426005559 putative Mg++ binding site [ion binding]; other site 326426005560 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 326426005561 nucleotide binding region [chemical binding]; other site 326426005562 ATP-binding site [chemical binding]; other site 326426005563 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 326426005564 YegV-like sugar kinase. Found only in bacteria, YegV-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YegV_kinase_like; cd01944 326426005565 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 326426005566 substrate binding site [chemical binding]; other site 326426005567 ATP binding site [chemical binding]; other site 326426005568 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 326426005569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426005570 putative substrate translocation pore; other site 326426005571 type II secretion system protein E; Region: type_II_gspE; TIGR02533 326426005572 RelB antitoxin; Region: RelB; cl01171 326426005573 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326426005574 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326426005575 non-specific DNA binding site [nucleotide binding]; other site 326426005576 salt bridge; other site 326426005577 sequence-specific DNA binding site [nucleotide binding]; other site 326426005578 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 326426005579 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326426005580 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 326426005581 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 326426005582 phosphate binding site [ion binding]; other site 326426005583 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 326426005584 FAS_MaoC, the MaoC-like hot dog fold of the fatty acid synthase, beta subunit. Other enzymes with this fold include MaoC dehydratase, Hydratase-Dehydrogenase-Epimerase protein (HDE), and 17-beta-hydroxysteriod dehydrogenase (HSD); Region: FAS_MaoC; cd03447 326426005585 putative active site [active] 326426005586 putative catalytic site [active] 326426005587 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 326426005588 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 326426005589 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 326426005590 putative NAD(P) binding site [chemical binding]; other site 326426005591 active site 326426005592 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 326426005593 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 326426005594 active site 326426005595 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 326426005596 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 326426005597 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 326426005598 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 326426005599 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 326426005600 ATP-grasp domain; Region: ATP-grasp_4; cl17255 326426005601 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 326426005602 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 326426005603 carboxyltransferase (CT) interaction site; other site 326426005604 biotinylation site [posttranslational modification]; other site 326426005605 BioY family; Region: BioY; pfam02632 326426005606 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 326426005607 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 326426005608 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 326426005609 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 326426005610 mRNA/rRNA interface [nucleotide binding]; other site 326426005611 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 326426005612 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 326426005613 23S rRNA interface [nucleotide binding]; other site 326426005614 L7/L12 interface [polypeptide binding]; other site 326426005615 putative thiostrepton binding site; other site 326426005616 L25 interface [polypeptide binding]; other site 326426005617 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 326426005618 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 326426005619 putative homodimer interface [polypeptide binding]; other site 326426005620 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 326426005621 heterodimer interface [polypeptide binding]; other site 326426005622 homodimer interface [polypeptide binding]; other site 326426005623 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 326426005624 aspartate aminotransferase; Provisional; Region: PRK05764 326426005625 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 326426005626 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426005627 homodimer interface [polypeptide binding]; other site 326426005628 catalytic residue [active] 326426005629 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 326426005630 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 326426005631 putative active site [active] 326426005632 putative metal binding site [ion binding]; other site 326426005633 gamma-glutamyl kinase; Provisional; Region: PRK05429 326426005634 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 326426005635 nucleotide binding site [chemical binding]; other site 326426005636 homotetrameric interface [polypeptide binding]; other site 326426005637 putative phosphate binding site [ion binding]; other site 326426005638 putative allosteric binding site; other site 326426005639 PUA domain; Region: PUA; pfam01472 326426005640 GTPase CgtA; Reviewed; Region: obgE; PRK12296 326426005641 GTP1/OBG; Region: GTP1_OBG; pfam01018 326426005642 Obg GTPase; Region: Obg; cd01898 326426005643 G1 box; other site 326426005644 GTP/Mg2+ binding site [chemical binding]; other site 326426005645 Switch I region; other site 326426005646 G2 box; other site 326426005647 G3 box; other site 326426005648 Switch II region; other site 326426005649 G4 box; other site 326426005650 G5 box; other site 326426005651 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 326426005652 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 326426005653 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 326426005654 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 326426005655 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 326426005656 homodimer interface [polypeptide binding]; other site 326426005657 oligonucleotide binding site [chemical binding]; other site 326426005658 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 326426005659 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 326426005660 metal binding site [ion binding]; metal-binding site 326426005661 putative dimer interface [polypeptide binding]; other site 326426005662 Predicted permeases [General function prediction only]; Region: COG0679 326426005663 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 326426005664 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 326426005665 inhibitor site; inhibition site 326426005666 active site 326426005667 dimer interface [polypeptide binding]; other site 326426005668 catalytic residue [active] 326426005669 Amidohydrolase; Region: Amidohydro_2; pfam04909 326426005670 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 326426005671 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 326426005672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426005673 putative substrate translocation pore; other site 326426005674 short chain dehydrogenase; Provisional; Region: PRK08628 326426005675 classical (c) SDRs; Region: SDR_c; cd05233 326426005676 NAD(P) binding site [chemical binding]; other site 326426005677 active site 326426005678 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 326426005679 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 326426005680 metal binding site [ion binding]; metal-binding site 326426005681 substrate binding pocket [chemical binding]; other site 326426005682 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426005683 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426005684 DNA binding site [nucleotide binding] 326426005685 domain linker motif; other site 326426005686 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426005687 dimerization interface [polypeptide binding]; other site 326426005688 ligand binding site [chemical binding]; other site 326426005689 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 326426005690 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426005691 Walker A/P-loop; other site 326426005692 ATP binding site [chemical binding]; other site 326426005693 Q-loop/lid; other site 326426005694 ABC transporter signature motif; other site 326426005695 Walker B; other site 326426005696 D-loop; other site 326426005697 H-loop/switch region; other site 326426005698 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 326426005699 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 326426005700 putative active site [active] 326426005701 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 326426005702 dimer interface [polypeptide binding]; other site 326426005703 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 326426005704 nudix motif; other site 326426005705 homoserine kinase; Provisional; Region: PRK01212 326426005706 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 326426005707 homoserine dehydrogenase; Provisional; Region: PRK06349 326426005708 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 326426005709 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 326426005710 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 326426005711 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 326426005712 catalytic residue [active] 326426005713 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 326426005714 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 326426005715 Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018 326426005716 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 326426005717 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 326426005718 active site 326426005719 HIGH motif; other site 326426005720 nucleotide binding site [chemical binding]; other site 326426005721 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 326426005722 KMSK motif region; other site 326426005723 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 326426005724 tRNA binding surface [nucleotide binding]; other site 326426005725 anticodon binding site; other site 326426005726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 326426005727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 326426005728 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426005729 H+ Antiporter protein; Region: 2A0121; TIGR00900 326426005730 putative substrate translocation pore; other site 326426005731 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 326426005732 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 326426005733 hinge; other site 326426005734 active site 326426005735 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 326426005736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326426005737 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 326426005738 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 326426005739 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 326426005740 substrate binding pocket [chemical binding]; other site 326426005741 membrane-bound complex binding site; other site 326426005742 hinge residues; other site 326426005743 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326426005744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005745 dimer interface [polypeptide binding]; other site 326426005746 conserved gate region; other site 326426005747 putative PBP binding loops; other site 326426005748 ABC-ATPase subunit interface; other site 326426005749 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 326426005750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005751 dimer interface [polypeptide binding]; other site 326426005752 conserved gate region; other site 326426005753 putative PBP binding loops; other site 326426005754 ABC-ATPase subunit interface; other site 326426005755 L-2-amino-thiazoline-4-carboxylic acid hydrolase; Region: ATC_hydrolase; pfam14196 326426005756 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 326426005757 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 326426005758 Walker A/P-loop; other site 326426005759 ATP binding site [chemical binding]; other site 326426005760 Q-loop/lid; other site 326426005761 ABC transporter signature motif; other site 326426005762 Walker B; other site 326426005763 D-loop; other site 326426005764 H-loop/switch region; other site 326426005765 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 326426005766 active site 326426005767 FMN binding site [chemical binding]; other site 326426005768 substrate binding site [chemical binding]; other site 326426005769 Uncharacterized conserved protein (DUF2368); Region: DUF2368; pfam10166 326426005770 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 326426005771 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 326426005772 substrate binding site [chemical binding]; other site 326426005773 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 326426005774 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 326426005775 substrate binding site [chemical binding]; other site 326426005776 ligand binding site [chemical binding]; other site 326426005777 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 326426005778 Transcriptional regulator [Transcription]; Region: IclR; COG1414 326426005779 Bacterial transcriptional regulator; Region: IclR; pfam01614 326426005780 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 326426005781 putative active site [active] 326426005782 putative metal binding site [ion binding]; other site 326426005783 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 326426005784 polyphosphate kinase; Provisional; Region: PRK05443 326426005785 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 326426005786 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 326426005787 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 326426005788 putative domain interface [polypeptide binding]; other site 326426005789 putative active site [active] 326426005790 catalytic site [active] 326426005791 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 326426005792 putative domain interface [polypeptide binding]; other site 326426005793 putative active site [active] 326426005794 catalytic site [active] 326426005795 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 326426005796 active site 326426005797 Ap6A binding site [chemical binding]; other site 326426005798 nudix motif; other site 326426005799 metal binding site [ion binding]; metal-binding site 326426005800 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426005801 catalytic core [active] 326426005802 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426005803 Integrase core domain; Region: rve; pfam00665 326426005804 transposase/IS protein; Provisional; Region: PRK09183 326426005805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426005806 Walker A motif; other site 326426005807 ATP binding site [chemical binding]; other site 326426005808 Walker B motif; other site 326426005809 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 326426005810 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426005811 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005812 ABC-ATPase subunit interface; other site 326426005813 putative PBP binding loops; other site 326426005814 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 326426005815 active site 326426005816 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 326426005817 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 326426005818 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 326426005819 active site 326426005820 catalytic site [active] 326426005821 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 326426005822 active site 326426005823 HIGH motif; other site 326426005824 nucleotide binding site [chemical binding]; other site 326426005825 active site 326426005826 KMSKS motif; other site 326426005827 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 326426005828 Clp amino terminal domain; Region: Clp_N; pfam02861 326426005829 Clp amino terminal domain; Region: Clp_N; pfam02861 326426005830 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426005831 Walker A motif; other site 326426005832 ATP binding site [chemical binding]; other site 326426005833 Walker B motif; other site 326426005834 arginine finger; other site 326426005835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426005836 Walker A motif; other site 326426005837 ATP binding site [chemical binding]; other site 326426005838 Walker B motif; other site 326426005839 arginine finger; other site 326426005840 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 326426005841 Membrane transport protein; Region: Mem_trans; cl09117 326426005842 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 326426005843 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 326426005844 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 326426005845 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 326426005846 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 326426005847 UDP-galactopyranose mutase; Region: GLF; pfam03275 326426005848 putative glycosyl transferase; Provisional; Region: PRK10073 326426005849 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326426005850 active site 326426005851 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 326426005852 Sulfatase; Region: Sulfatase; pfam00884 326426005853 Sulfatase; Region: Sulfatase; pfam00884 326426005854 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 326426005855 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 326426005856 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 326426005857 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 326426005858 Walker A/P-loop; other site 326426005859 ATP binding site [chemical binding]; other site 326426005860 Q-loop/lid; other site 326426005861 ABC transporter signature motif; other site 326426005862 Walker B; other site 326426005863 D-loop; other site 326426005864 H-loop/switch region; other site 326426005865 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 326426005866 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 326426005867 Rhamnan synthesis protein F; Region: RgpF; pfam05045 326426005868 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 326426005869 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 326426005870 active site 326426005871 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 326426005872 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 326426005873 substrate binding site; other site 326426005874 tetramer interface; other site 326426005875 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 326426005876 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 326426005877 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 326426005878 NADP binding site [chemical binding]; other site 326426005879 active site 326426005880 putative substrate binding site [chemical binding]; other site 326426005881 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 326426005882 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 326426005883 NAD binding site [chemical binding]; other site 326426005884 substrate binding site [chemical binding]; other site 326426005885 homodimer interface [polypeptide binding]; other site 326426005886 active site 326426005887 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 326426005888 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 326426005889 Ligand binding site; other site 326426005890 Putative Catalytic site; other site 326426005891 DXD motif; other site 326426005892 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 326426005893 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 326426005894 active site 326426005895 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 326426005896 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 326426005897 FtsX-like permease family; Region: FtsX; pfam02687 326426005898 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426005899 ABC transporter; Region: ABC_tran; pfam00005 326426005900 Q-loop/lid; other site 326426005901 ABC transporter signature motif; other site 326426005902 Walker B; other site 326426005903 D-loop; other site 326426005904 H-loop/switch region; other site 326426005905 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326426005906 Zn2+ binding site [ion binding]; other site 326426005907 Mg2+ binding site [ion binding]; other site 326426005908 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 326426005909 putative active site [active] 326426005910 putative dimer interface [polypeptide binding]; other site 326426005911 K+ potassium transporter; Region: K_trans; pfam02705 326426005912 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 326426005913 active site 326426005914 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326426005915 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326426005916 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 326426005917 Walker A/P-loop; other site 326426005918 ATP binding site [chemical binding]; other site 326426005919 Q-loop/lid; other site 326426005920 ABC transporter signature motif; other site 326426005921 Walker B; other site 326426005922 D-loop; other site 326426005923 H-loop/switch region; other site 326426005924 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326426005925 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326426005926 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426005927 Walker A/P-loop; other site 326426005928 ATP binding site [chemical binding]; other site 326426005929 Q-loop/lid; other site 326426005930 ABC transporter signature motif; other site 326426005931 Walker B; other site 326426005932 D-loop; other site 326426005933 H-loop/switch region; other site 326426005934 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426005935 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373 326426005936 Walker A motif; other site 326426005937 ATP binding site [chemical binding]; other site 326426005938 Walker B motif; other site 326426005939 The substrate-binding domain of mycobacterial lipoprotein Lpqw contains type 2 periplasmic binding fold; Region: PBP2_Lpqw; cd08501 326426005940 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 326426005941 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 326426005942 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326426005943 Walker A/P-loop; other site 326426005944 ATP binding site [chemical binding]; other site 326426005945 Q-loop/lid; other site 326426005946 ABC transporter signature motif; other site 326426005947 Walker B; other site 326426005948 D-loop; other site 326426005949 H-loop/switch region; other site 326426005950 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 326426005951 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 326426005952 Walker A/P-loop; other site 326426005953 ATP binding site [chemical binding]; other site 326426005954 Q-loop/lid; other site 326426005955 ABC transporter signature motif; other site 326426005956 Walker B; other site 326426005957 D-loop; other site 326426005958 H-loop/switch region; other site 326426005959 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 326426005960 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 326426005961 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005962 dimer interface [polypeptide binding]; other site 326426005963 conserved gate region; other site 326426005964 putative PBP binding loops; other site 326426005965 ABC-ATPase subunit interface; other site 326426005966 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 326426005967 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426005968 dimer interface [polypeptide binding]; other site 326426005969 conserved gate region; other site 326426005970 putative PBP binding loops; other site 326426005971 ABC-ATPase subunit interface; other site 326426005972 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 326426005973 trimer interface [polypeptide binding]; other site 326426005974 active site 326426005975 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 326426005976 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 326426005977 active site 326426005978 HIGH motif; other site 326426005979 KMSKS motif; other site 326426005980 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 326426005981 tRNA binding surface [nucleotide binding]; other site 326426005982 anticodon binding site; other site 326426005983 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 326426005984 Predicted methyltransferases [General function prediction only]; Region: COG0313 326426005985 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 326426005986 putative SAM binding site [chemical binding]; other site 326426005987 putative homodimer interface [polypeptide binding]; other site 326426005988 MFS/sugar transport protein; Region: MFS_2; pfam13347 326426005989 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 326426005990 ApbE family; Region: ApbE; pfam02424 326426005991 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326426005992 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326426005993 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 326426005994 Walker A/P-loop; other site 326426005995 ATP binding site [chemical binding]; other site 326426005996 Q-loop/lid; other site 326426005997 ABC transporter signature motif; other site 326426005998 Walker B; other site 326426005999 D-loop; other site 326426006000 H-loop/switch region; other site 326426006001 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 326426006002 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 326426006003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 326426006004 Walker A/P-loop; other site 326426006005 ATP binding site [chemical binding]; other site 326426006006 Q-loop/lid; other site 326426006007 ABC transporter signature motif; other site 326426006008 Walker B; other site 326426006009 D-loop; other site 326426006010 H-loop/switch region; other site 326426006011 MarR family; Region: MarR_2; cl17246 326426006012 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 326426006013 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 326426006014 trimer interface [polypeptide binding]; other site 326426006015 putative acyl transferase; Provisional; Region: PRK10191 326426006016 active site 326426006017 substrate binding site [chemical binding]; other site 326426006018 CoA binding site [chemical binding]; other site 326426006019 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426006020 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426006021 DNA binding site [nucleotide binding] 326426006022 domain linker motif; other site 326426006023 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 326426006024 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 326426006025 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 326426006026 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 326426006027 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 326426006028 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 326426006029 TM-ABC transporter signature motif; other site 326426006030 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 326426006031 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 326426006032 Walker A/P-loop; other site 326426006033 ATP binding site [chemical binding]; other site 326426006034 Q-loop/lid; other site 326426006035 ABC transporter signature motif; other site 326426006036 Walker B; other site 326426006037 D-loop; other site 326426006038 H-loop/switch region; other site 326426006039 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 326426006040 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_7; cd06316 326426006041 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 326426006042 putative ligand binding site [chemical binding]; other site 326426006043 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 326426006044 Integrase core domain; Region: rve; pfam00665 326426006045 transposase/IS protein; Provisional; Region: PRK09183 326426006046 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 326426006047 Walker A motif; other site 326426006048 ATP binding site [chemical binding]; other site 326426006049 Walker B motif; other site 326426006050 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 326426006051 FtsX-like permease family; Region: FtsX; pfam02687 326426006052 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 326426006053 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 326426006054 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 326426006055 Walker A/P-loop; other site 326426006056 ATP binding site [chemical binding]; other site 326426006057 Q-loop/lid; other site 326426006058 ABC transporter signature motif; other site 326426006059 Walker B; other site 326426006060 D-loop; other site 326426006061 H-loop/switch region; other site 326426006062 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 326426006063 Protein of unknown function, DUF624; Region: DUF624; pfam04854 326426006064 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426006065 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426006066 dimer interface [polypeptide binding]; other site 326426006067 conserved gate region; other site 326426006068 putative PBP binding loops; other site 326426006069 ABC-ATPase subunit interface; other site 326426006070 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 326426006071 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426006072 putative PBP binding loops; other site 326426006073 dimer interface [polypeptide binding]; other site 326426006074 ABC-ATPase subunit interface; other site 326426006075 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426006076 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426006077 DNA binding site [nucleotide binding] 326426006078 domain linker motif; other site 326426006079 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426006080 ligand binding site [chemical binding]; other site 326426006081 dimerization interface [polypeptide binding]; other site 326426006082 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326426006083 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426006084 catalytic core [active] 326426006085 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 326426006086 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 326426006087 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 326426006088 dimer interface [polypeptide binding]; other site 326426006089 FMN binding site [chemical binding]; other site 326426006090 NADPH bind site [chemical binding]; other site 326426006091 Predicted membrane protein [Function unknown]; Region: COG1511 326426006092 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 326426006093 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 326426006094 Predicted membrane protein [Function unknown]; Region: COG1511 326426006095 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 326426006096 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 326426006097 NAD-dependent deacetylase; Provisional; Region: PRK00481 326426006098 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 326426006099 threonine dehydratase; Provisional; Region: PRK08198 326426006100 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 326426006101 tetramer interface [polypeptide binding]; other site 326426006102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 326426006103 catalytic residue [active] 326426006104 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 326426006105 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 326426006106 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 326426006107 Ca binding site [ion binding]; other site 326426006108 active site 326426006109 catalytic site [active] 326426006110 probable galactinol--sucrose galactosyltransferase 1; Region: PLN02355 326426006111 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 326426006112 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 326426006113 active site 326426006114 catalytic site [active] 326426006115 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426006116 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426006117 dimer interface [polypeptide binding]; other site 326426006118 conserved gate region; other site 326426006119 putative PBP binding loops; other site 326426006120 ABC-ATPase subunit interface; other site 326426006121 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 326426006122 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426006123 dimer interface [polypeptide binding]; other site 326426006124 conserved gate region; other site 326426006125 putative PBP binding loops; other site 326426006126 ABC-ATPase subunit interface; other site 326426006127 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426006128 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426006129 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 326426006130 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 326426006131 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426006132 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426006133 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426006134 DNA binding site [nucleotide binding] 326426006135 domain linker motif; other site 326426006136 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426006137 ligand binding site [chemical binding]; other site 326426006138 dimerization interface [polypeptide binding]; other site 326426006139 Transcriptional regulators [Transcription]; Region: PurR; COG1609 326426006140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 326426006141 DNA binding site [nucleotide binding] 326426006142 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 326426006143 ligand binding site [chemical binding]; other site 326426006144 dimerization interface [polypeptide binding]; other site 326426006145 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 326426006146 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426006147 dimer interface [polypeptide binding]; other site 326426006148 conserved gate region; other site 326426006149 putative PBP binding loops; other site 326426006150 ABC-ATPase subunit interface; other site 326426006151 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 326426006152 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 326426006153 dimer interface [polypeptide binding]; other site 326426006154 conserved gate region; other site 326426006155 putative PBP binding loops; other site 326426006156 ABC-ATPase subunit interface; other site 326426006157 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 326426006158 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 326426006159 Transcriptional regulators [Transcription]; Region: MarR; COG1846 326426006160 MarR family; Region: MarR_2; pfam12802 326426006161 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 326426006162 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 326426006163 nucleotide binding site [chemical binding]; other site 326426006164 Melibiase; Region: Melibiase; pfam02065 326426006165 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 326426006166 nucleoside/Zn binding site; other site 326426006167 dimer interface [polypeptide binding]; other site 326426006168 catalytic motif [active] 326426006169 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 326426006170 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 326426006171 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 326426006172 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 326426006173 trimer interface [polypeptide binding]; other site 326426006174 active site 326426006175 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 326426006176 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 326426006177 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 326426006178 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 326426006179 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 326426006180 active site 326426006181 motif I; other site 326426006182 motif II; other site 326426006183 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 326426006184 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 326426006185 HPr interaction site; other site 326426006186 glycerol kinase (GK) interaction site [polypeptide binding]; other site 326426006187 active site 326426006188 phosphorylation site [posttranslational modification] 326426006189 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 326426006190 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 326426006191 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cl00164 326426006192 active site turn [active] 326426006193 phosphorylation site [posttranslational modification] 326426006194 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 326426006195 Major Facilitator Superfamily; Region: MFS_1; pfam07690 326426006196 putative substrate translocation pore; other site 326426006197 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 326426006198 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 326426006199 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 326426006200 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 326426006201 active site 326426006202 phosphate binding residues; other site 326426006203 catalytic residues [active] 326426006204 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 326426006205 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 326426006206 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 326426006207 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 326426006208 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 326426006209 active site 326426006210 catalytic site [active] 326426006211 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 326426006212 Cna protein B-type domain; Region: Cna_B; pfam05738 326426006213 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 326426006214 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 326426006215 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 326426006216 Walker A/P-loop; other site 326426006217 ATP binding site [chemical binding]; other site 326426006218 Q-loop/lid; other site 326426006219 ABC transporter signature motif; other site 326426006220 Walker B; other site 326426006221 D-loop; other site 326426006222 H-loop/switch region; other site 326426006223 TOBE domain; Region: TOBE_2; pfam08402 326426006224 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 326426006225 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 326426006226 DNA-binding site [nucleotide binding]; DNA binding site 326426006227 UTRA domain; Region: UTRA; pfam07702 326426006228 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 326426006229 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 326426006230 active site 326426006231 P-loop; other site 326426006232 phosphorylation site [posttranslational modification] 326426006233 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 326426006234 active site 326426006235 phosphorylation site [posttranslational modification] 326426006236 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 326426006237 active site 326426006238 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 326426006239 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 326426006240 active site 326426006241 phosphorylation site [posttranslational modification] 326426006242 intermolecular recognition site; other site 326426006243 dimerization interface [polypeptide binding]; other site 326426006244 LytTr DNA-binding domain; Region: LytTR; smart00850 326426006245 Domain of unknown function (DUF4401); Region: DUF4401; pfam14351 326426006246 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 326426006247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 326426006248 ATP binding site [chemical binding]; other site 326426006249 Mg2+ binding site [ion binding]; other site 326426006250 G-X-G motif; other site 326426006251 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 326426006252 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 326426006253 dimer interface [polypeptide binding]; other site 326426006254 putative radical transfer pathway; other site 326426006255 diiron center [ion binding]; other site 326426006256 tyrosyl radical; other site 326426006257 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 326426006258 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 326426006259 Class I ribonucleotide reductase; Region: RNR_I; cd01679 326426006260 active site 326426006261 dimer interface [polypeptide binding]; other site 326426006262 catalytic residues [active] 326426006263 effector binding site; other site 326426006264 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 326426006265 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 326426006266 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 326426006267 catalytic residues [active] 326426006268 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 326426006269 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 326426006270 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 326426006271 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 326426006272 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 326426006273 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 326426006274 non-specific DNA binding site [nucleotide binding]; other site 326426006275 salt bridge; other site 326426006276 sequence-specific DNA binding site [nucleotide binding]; other site 326426006277 Protein of unknown function (DUF3990); Region: DUF3990; pfam13151 326426006278 Ion channel; Region: Ion_trans_2; pfam07885 326426006279 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 326426006280 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 326426006281 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 326426006282 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 326426006283 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 326426006284 Catalytic domain of Protein Kinases; Region: PKc; cd00180 326426006285 active site 326426006286 ATP binding site [chemical binding]; other site 326426006287 substrate binding site [chemical binding]; other site 326426006288 activation loop (A-loop); other site 326426006289 Gamma interferon inducible lysosomal thiol reductase (GILT); Region: GILT; pfam03227 326426006290 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 326426006291 Domain of unknown function (DUF348); Region: DUF348; pfam03990 326426006292 Domain of unknown function (DUF348); Region: DUF348; pfam03990 326426006293 G5 domain; Region: G5; pfam07501 326426006294 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 326426006295 N-acetyl-D-glucosamine binding site [chemical binding]; other site 326426006296 catalytic residue [active] 326426006297 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 326426006298 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 326426006299 S-adenosylmethionine binding site [chemical binding]; other site 326426006300 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK03188 326426006301 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 326426006302 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 326426006303 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 326426006304 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 326426006305 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 326426006306 active site 326426006307 NTP binding site [chemical binding]; other site 326426006308 metal binding triad [ion binding]; metal-binding site 326426006309 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 326426006310 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 326426006311 Zn2+ binding site [ion binding]; other site 326426006312 Mg2+ binding site [ion binding]; other site 326426006313 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 326426006314 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 326426006315 active site 326426006316 Ap6A binding site [chemical binding]; other site 326426006317 nudix motif; other site 326426006318 metal binding site [ion binding]; metal-binding site 326426006319 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 326426006320 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 326426006321 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 326426006322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 326426006323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 326426006324 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 326426006325 ParB-like nuclease domain; Region: ParB; smart00470 326426006326 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 326426006327 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326426006328 P-loop; other site 326426006329 Magnesium ion binding site [ion binding]; other site 326426006330 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 326426006331 Magnesium ion binding site [ion binding]; other site 326426006332 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 326426006333 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 326426006334 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 326426006335 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 326426006336 G-X-X-G motif; other site 326426006337 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 326426006338 RxxxH motif; other site 326426006339 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01315 326426006340 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 326426006341 hypothetical protein; Provisional; Region: PRK14372 326426006342 Ribonuclease P; Region: Ribonuclease_P; pfam00825 326426006343 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399