-- dump date 20140619_002529 -- class Genbank::misc_feature -- table misc_feature_note -- id note 401473000001 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 401473000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473000003 Walker A motif; other site 401473000004 ATP binding site [chemical binding]; other site 401473000005 Walker B motif; other site 401473000006 arginine finger; other site 401473000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 401473000008 DnaA box-binding interface [nucleotide binding]; other site 401473000009 DNA polymerase III subunit beta; Validated; Region: PRK07761 401473000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 401473000011 putative DNA binding surface [nucleotide binding]; other site 401473000012 dimer interface [polypeptide binding]; other site 401473000013 beta-clamp/clamp loader binding surface; other site 401473000014 beta-clamp/translesion DNA polymerase binding surface; other site 401473000015 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 401473000016 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473000017 Walker A/P-loop; other site 401473000018 ATP binding site [chemical binding]; other site 401473000019 Q-loop/lid; other site 401473000020 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473000021 ABC transporter signature motif; other site 401473000022 Walker B; other site 401473000023 D-loop; other site 401473000024 H-loop/switch region; other site 401473000025 Protein of unknown function (DUF721); Region: DUF721; pfam05258 401473000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 401473000027 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 401473000028 anchoring element; other site 401473000029 dimer interface [polypeptide binding]; other site 401473000030 ATP binding site [chemical binding]; other site 401473000031 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 401473000032 active site 401473000033 putative metal-binding site [ion binding]; other site 401473000034 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 401473000035 DNA gyrase subunit A; Validated; Region: PRK05560 401473000036 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 401473000037 CAP-like domain; other site 401473000038 active site 401473000039 primary dimer interface [polypeptide binding]; other site 401473000040 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401473000041 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401473000042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401473000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401473000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 401473000045 Transmembrane domain of unknown function (DUF3566); Region: DUF3566; pfam12089 401473000046 glutamate dehydrogenase; Provisional; Region: PRK09414 401473000047 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 401473000048 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 401473000049 NAD(P) binding site [chemical binding]; other site 401473000050 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473000051 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473000052 DNA binding site [nucleotide binding] 401473000053 domain linker motif; other site 401473000054 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 401473000055 putative dimerization interface [polypeptide binding]; other site 401473000056 putative ligand binding site [chemical binding]; other site 401473000057 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 401473000058 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 401473000059 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 401473000060 substrate binding site [chemical binding]; other site 401473000061 ATP binding site [chemical binding]; other site 401473000062 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 401473000063 phosphate binding site [ion binding]; other site 401473000064 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 401473000065 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 401473000066 tetramer interface [polypeptide binding]; other site 401473000067 active site 401473000068 Large-conductance mechanosensitive channel, MscL; Region: MscL; cl00860 401473000069 Protein of unknown function DUF45; Region: DUF45; pfam01863 401473000070 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 401473000071 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 401473000072 dimerization interface [polypeptide binding]; other site 401473000073 DPS ferroxidase diiron center [ion binding]; other site 401473000074 ion pore; other site 401473000075 Domain of unknown function DUF21; Region: DUF21; pfam01595 401473000076 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 401473000077 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 401473000078 Transporter associated domain; Region: CorC_HlyC; smart01091 401473000079 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391 401473000080 active site clefts [active] 401473000081 zinc binding site [ion binding]; other site 401473000082 dimer interface [polypeptide binding]; other site 401473000083 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 401473000084 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 401473000085 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 401473000086 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 401473000087 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 401473000088 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 401473000089 Na binding site [ion binding]; other site 401473000090 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 401473000091 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 401473000092 active site 401473000093 HIGH motif; other site 401473000094 dimer interface [polypeptide binding]; other site 401473000095 KMSKS motif; other site 401473000096 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 401473000097 homodimer interface [polypeptide binding]; other site 401473000098 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 401473000099 active site pocket [active] 401473000100 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 401473000101 putative septation inhibitor protein; Reviewed; Region: PRK02251 401473000102 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 401473000103 Sortase D (SrtD) is a membrane transpeptidase found in gram-positive bacteria that anchors surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the surface protein substrate is cleaved...; Region: Sortase_D_5; cd05830 401473000104 active site 401473000105 catalytic site [active] 401473000106 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 401473000107 Glutamine amidotransferase class-I; Region: GATase; pfam00117 401473000108 glutamine binding [chemical binding]; other site 401473000109 catalytic triad [active] 401473000110 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 401473000111 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 401473000112 active site 401473000113 ATP binding site [chemical binding]; other site 401473000114 substrate binding site [chemical binding]; other site 401473000115 activation loop (A-loop); other site 401473000116 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 401473000117 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 401473000118 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 401473000119 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 401473000120 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 401473000121 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 401473000122 active site 401473000123 ATP binding site [chemical binding]; other site 401473000124 substrate binding site [chemical binding]; other site 401473000125 activation loop (A-loop); other site 401473000126 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 401473000127 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 401473000128 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 401473000129 active site 401473000130 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 401473000131 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 401473000132 phosphopeptide binding site; other site 401473000133 Protein of unknown function (DUF2662); Region: DUF3662; pfam12401 401473000134 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 401473000135 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 401473000136 phosphopeptide binding site; other site 401473000137 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 401473000138 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 401473000139 Predicted membrane protein [Function unknown]; Region: COG1511 401473000140 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 401473000141 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 401473000142 Predicted membrane protein [Function unknown]; Region: COG1511 401473000143 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 401473000144 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 401473000145 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 401473000146 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 401473000147 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 401473000148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473000149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473000150 homodimer interface [polypeptide binding]; other site 401473000151 catalytic residue [active] 401473000152 EamA-like transporter family; Region: EamA; pfam00892 401473000153 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 401473000154 NADH(P)-binding; Region: NAD_binding_10; pfam13460 401473000155 NAD binding site [chemical binding]; other site 401473000156 substrate binding site [chemical binding]; other site 401473000157 putative active site [active] 401473000158 Predicted transcriptional regulators [Transcription]; Region: COG1733 401473000159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401473000160 putative DNA binding site [nucleotide binding]; other site 401473000161 putative Zn2+ binding site [ion binding]; other site 401473000162 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 401473000163 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 401473000164 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 401473000165 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 401473000166 protein binding site [polypeptide binding]; other site 401473000167 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 401473000168 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 401473000169 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 401473000170 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473000171 motif II; other site 401473000172 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 401473000173 active site 401473000174 homodimer interface [polypeptide binding]; other site 401473000175 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 401473000176 ferredoxin-NADP+ reductase; Region: PLN02852 401473000177 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 401473000178 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 401473000179 heat shock protein HtpX; Provisional; Region: PRK03072 401473000180 Similar to ISSde12 12bp perfect TIRs 401473000181 integrase; Provisional; Region: int; PHA02601 401473000182 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 401473000183 active site 401473000184 DNA binding site [nucleotide binding] 401473000185 Int/Topo IB signature motif; other site 401473000186 Abi-like protein; Region: Abi_2; pfam07751 401473000187 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 401473000188 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 401473000189 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 401473000190 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473000191 Walker A/P-loop; other site 401473000192 ATP binding site [chemical binding]; other site 401473000193 Q-loop/lid; other site 401473000194 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 401473000195 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 401473000196 putative active site [active] 401473000197 putative FMN binding site [chemical binding]; other site 401473000198 putative substrate binding site [chemical binding]; other site 401473000199 putative catalytic residue [active] 401473000200 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401473000201 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 401473000202 NAD(P) binding site [chemical binding]; other site 401473000203 active site 401473000204 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473000205 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473000206 Protein of unknown function (DUF2442); Region: DUF2442; pfam10387 401473000207 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 401473000208 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 401473000209 Shugoshin N-terminal coiled-coil region; Region: Shugoshin_N; pfam07558 401473000210 Nitroreductase family; Region: Nitroreductase; pfam00881 401473000211 FMN binding site [chemical binding]; other site 401473000212 dimer interface [polypeptide binding]; other site 401473000213 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 401473000214 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401473000215 non-specific DNA binding site [nucleotide binding]; other site 401473000216 salt bridge; other site 401473000217 sequence-specific DNA binding site [nucleotide binding]; other site 401473000218 aromatic amino acid exporter; Provisional; Region: PRK11689 401473000219 EamA-like transporter family; Region: EamA; pfam00892 401473000220 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 401473000221 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 401473000222 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 401473000223 active site 401473000224 intersubunit interface [polypeptide binding]; other site 401473000225 zinc binding site [ion binding]; other site 401473000226 Na+ binding site [ion binding]; other site 401473000227 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 401473000228 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 401473000229 NodB motif; other site 401473000230 active site 401473000231 catalytic site [active] 401473000232 metal binding site [ion binding]; metal-binding site 401473000233 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 401473000234 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 401473000235 GDP-binding site [chemical binding]; other site 401473000236 ACT binding site; other site 401473000237 IMP binding site; other site 401473000238 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 401473000239 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 401473000240 Cl- selectivity filter; other site 401473000241 Cl- binding residues [ion binding]; other site 401473000242 pore gating glutamate residue; other site 401473000243 dimer interface [polypeptide binding]; other site 401473000244 H+/Cl- coupling transport residue; other site 401473000245 TrkA-C domain; Region: TrkA_C; pfam02080 401473000246 CrcB-like protein; Region: CRCB; pfam02537 401473000247 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 401473000248 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 401473000249 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 401473000250 TM-ABC transporter signature motif; other site 401473000251 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 401473000252 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 401473000253 TM-ABC transporter signature motif; other site 401473000254 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 401473000255 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 401473000256 Walker A/P-loop; other site 401473000257 ATP binding site [chemical binding]; other site 401473000258 Q-loop/lid; other site 401473000259 ABC transporter signature motif; other site 401473000260 Walker B; other site 401473000261 D-loop; other site 401473000262 H-loop/switch region; other site 401473000263 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 401473000264 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 401473000265 Walker A/P-loop; other site 401473000266 ATP binding site [chemical binding]; other site 401473000267 Q-loop/lid; other site 401473000268 ABC transporter signature motif; other site 401473000269 Walker B; other site 401473000270 D-loop; other site 401473000271 H-loop/switch region; other site 401473000272 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 401473000273 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 401473000274 ligand binding site [chemical binding]; other site 401473000275 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 401473000276 Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268 401473000277 ligand binding site [chemical binding]; other site 401473000278 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473000279 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473000280 DNA binding site [nucleotide binding] 401473000281 domain linker motif; other site 401473000282 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 401473000283 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 401473000284 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 401473000285 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473000286 catalytic residue [active] 401473000287 hypothetical protein; Provisional; Region: PRK05463 401473000288 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 401473000289 putative active site [active] 401473000290 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 401473000291 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049 401473000292 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 401473000293 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 401473000294 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401473000295 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401473000296 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 401473000297 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 401473000298 carboxyltransferase (CT) interaction site; other site 401473000299 biotinylation site [posttranslational modification]; other site 401473000300 Domain of unknown function (DUF4392); Region: DUF4392; pfam14336 401473000301 sucrose phosphorylase; Provisional; Region: PRK13840 401473000302 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 401473000303 active site 401473000304 homodimer interface [polypeptide binding]; other site 401473000305 catalytic site [active] 401473000306 Domain of unknown function (DUF1964); Region: DUF1964; pfam09244 401473000307 Protein of unknown function, DUF624; Region: DUF624; pfam04854 401473000308 Protein of unknown function, DUF624; Region: DUF624; cl02369 401473000309 trehalose synthase; Region: treS_nterm; TIGR02456 401473000310 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_2; cd11348 401473000311 active site 401473000312 catalytic site [active] 401473000313 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473000314 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473000315 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 401473000316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473000317 dimer interface [polypeptide binding]; other site 401473000318 conserved gate region; other site 401473000319 putative PBP binding loops; other site 401473000320 ABC-ATPase subunit interface; other site 401473000321 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473000322 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473000323 dimer interface [polypeptide binding]; other site 401473000324 conserved gate region; other site 401473000325 putative PBP binding loops; other site 401473000326 ABC-ATPase subunit interface; other site 401473000327 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473000328 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473000329 putative substrate translocation pore; other site 401473000330 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473000331 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473000332 metabolite-proton symporter; Region: 2A0106; TIGR00883 401473000333 putative substrate translocation pore; other site 401473000334 ketol-acid reductoisomerase; Provisional; Region: PRK05479 401473000335 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 401473000336 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 401473000337 ketol-acid reductoisomerase; Provisional; Region: PRK05479 401473000338 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 401473000339 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 401473000340 Similar to ISBlo3 ISBlo3 24-24bpTIRs 401473000341 Helix-turn-helix domain; Region: HTH_28; pfam13518 401473000342 Transposase; Region: HTH_Tnp_1; cl17663 401473000343 putative transposase OrfB; Reviewed; Region: PHA02517 401473000344 HTH-like domain; Region: HTH_21; pfam13276 401473000345 Integrase core domain; Region: rve; pfam00665 401473000346 Integrase core domain; Region: rve_2; pfam13333 401473000347 Domain of unknown function (DUF303); Region: DUF303; pfam03629 401473000348 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 401473000349 active site 401473000350 catalytic triad [active] 401473000351 oxyanion hole [active] 401473000352 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 401473000353 beta-galactosidase; Region: BGL; TIGR03356 401473000354 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473000355 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473000356 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473000357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473000358 putative PBP binding loops; other site 401473000359 dimer interface [polypeptide binding]; other site 401473000360 ABC-ATPase subunit interface; other site 401473000361 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473000362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473000363 dimer interface [polypeptide binding]; other site 401473000364 conserved gate region; other site 401473000365 putative PBP binding loops; other site 401473000366 ABC-ATPase subunit interface; other site 401473000367 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 401473000368 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 401473000369 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473000370 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473000371 DNA binding site [nucleotide binding] 401473000372 domain linker motif; other site 401473000373 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473000374 ligand binding site [chemical binding]; other site 401473000375 dimerization interface [polypeptide binding]; other site 401473000376 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 401473000377 active site 401473000378 Protein of unknown function, DUF624; Region: DUF624; pfam04854 401473000379 Melibiase; Region: Melibiase; pfam02065 401473000380 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 401473000381 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473000382 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473000383 DNA binding site [nucleotide binding] 401473000384 domain linker motif; other site 401473000385 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473000386 dimerization interface [polypeptide binding]; other site 401473000387 ligand binding site [chemical binding]; other site 401473000388 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 401473000389 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473000390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473000391 dimer interface [polypeptide binding]; other site 401473000392 conserved gate region; other site 401473000393 putative PBP binding loops; other site 401473000394 ABC-ATPase subunit interface; other site 401473000395 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473000396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473000397 dimer interface [polypeptide binding]; other site 401473000398 conserved gate region; other site 401473000399 putative PBP binding loops; other site 401473000400 ABC-ATPase subunit interface; other site 401473000401 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473000402 Flagellar FliJ protein; Region: FliJ; pfam02050 401473000403 FlxA-like protein; Region: FlxA; pfam14282 401473000404 FtsX-like permease family; Region: FtsX; pfam02687 401473000405 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 401473000406 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 401473000407 active site 401473000408 catalytic site [active] 401473000409 legume lectins; Region: lectin_L-type; cl14058 401473000410 homotetramer interaction site [polypeptide binding]; other site 401473000411 carbohydrate binding site [chemical binding]; other site 401473000412 metal binding site [ion binding]; metal-binding site 401473000413 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 401473000414 metal ion-dependent adhesion site (MIDAS); other site 401473000415 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 401473000416 domain interaction interfaces [polypeptide binding]; other site 401473000417 T surface-antigen of pili; Region: FctA; cl16948 401473000418 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 401473000419 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 401473000420 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 401473000421 ThiS interaction site; other site 401473000422 putative active site [active] 401473000423 tetramer interface [polypeptide binding]; other site 401473000424 thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644 401473000425 E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487 401473000426 putative ATP binding site [chemical binding]; other site 401473000427 putative substrate interface [chemical binding]; other site 401473000428 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 401473000429 thiS-thiF/thiG interaction site; other site 401473000430 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401473000431 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 401473000432 active site 401473000433 catalytic tetrad [active] 401473000434 MarR family; Region: MarR; pfam01047 401473000435 Transcriptional regulators [Transcription]; Region: MarR; COG1846 401473000436 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401473000437 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401473000438 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473000439 Walker A/P-loop; other site 401473000440 ATP binding site [chemical binding]; other site 401473000441 Q-loop/lid; other site 401473000442 ABC transporter signature motif; other site 401473000443 Walker B; other site 401473000444 D-loop; other site 401473000445 H-loop/switch region; other site 401473000446 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401473000447 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401473000448 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 401473000449 Walker A/P-loop; other site 401473000450 ATP binding site [chemical binding]; other site 401473000451 Q-loop/lid; other site 401473000452 ABC transporter signature motif; other site 401473000453 Walker B; other site 401473000454 D-loop; other site 401473000455 H-loop/switch region; other site 401473000456 AAA ATPase domain; Region: AAA_16; pfam13191 401473000457 ApbE family; Region: ApbE; pfam02424 401473000458 MFS/sugar transport protein; Region: MFS_2; pfam13347 401473000459 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 401473000460 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473000461 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473000462 DNA binding site [nucleotide binding] 401473000463 domain linker motif; other site 401473000464 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473000465 dimerization interface [polypeptide binding]; other site 401473000466 ligand binding site [chemical binding]; other site 401473000467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473000468 putative substrate translocation pore; other site 401473000469 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 401473000470 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 401473000471 MFS/sugar transport protein; Region: MFS_2; pfam13347 401473000472 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473000473 putative substrate translocation pore; other site 401473000474 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 401473000475 Fe2+ transport protein; Region: Iron_transport; pfam10634 401473000476 Predicted membrane protein [Function unknown]; Region: COG4393 401473000477 Predicted membrane protein (DUF2318); Region: DUF2318; pfam10080 401473000478 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473000479 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 401473000480 FtsX-like permease family; Region: FtsX; pfam02687 401473000481 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473000482 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 401473000483 FtsX-like permease family; Region: FtsX; pfam02687 401473000484 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473000485 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473000486 Walker A/P-loop; other site 401473000487 ATP binding site [chemical binding]; other site 401473000488 Q-loop/lid; other site 401473000489 ABC transporter signature motif; other site 401473000490 Walker B; other site 401473000491 D-loop; other site 401473000492 H-loop/switch region; other site 401473000493 This conserved region includes the FMN-binding site of the NqrC protein as well as the NosR and NirI regulatory proteins; Region: FMN_bind; smart00900 401473000494 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473000495 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473000496 DNA binding site [nucleotide binding] 401473000497 domain linker motif; other site 401473000498 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473000499 dimerization interface [polypeptide binding]; other site 401473000500 ligand binding site [chemical binding]; other site 401473000501 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473000502 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473000503 DNA binding site [nucleotide binding] 401473000504 domain linker motif; other site 401473000505 Ligand-binding domain of DNA-binding regulatory protein from Corynebacterium glutamicum which has a unique ability to produce significant amounts of L-glutamate directly from cheap sugar and ammonia; Region: PBP1_LacI_like_13; cd06299 401473000506 dimerization interface [polypeptide binding]; other site 401473000507 putative ligand binding site [chemical binding]; other site 401473000508 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 401473000509 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 401473000510 Walker A/P-loop; other site 401473000511 ATP binding site [chemical binding]; other site 401473000512 Q-loop/lid; other site 401473000513 ABC transporter signature motif; other site 401473000514 Walker B; other site 401473000515 D-loop; other site 401473000516 H-loop/switch region; other site 401473000517 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 401473000518 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 401473000519 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 401473000520 TM-ABC transporter signature motif; other site 401473000521 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 401473000522 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 401473000523 ligand binding site [chemical binding]; other site 401473000524 dimerization interface [polypeptide binding]; other site 401473000525 D-ribose pyranase; Provisional; Region: PRK11797 401473000526 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473000527 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473000528 Predicted membrane protein [Function unknown]; Region: COG1511 401473000529 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 401473000530 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 401473000531 Predicted membrane protein [Function unknown]; Region: COG1511 401473000532 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 401473000533 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 401473000534 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 401473000535 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 401473000536 catalytic residues [active] 401473000537 Peptidase family C69; Region: Peptidase_C69; cl17793 401473000538 Peptidase family C69; Region: Peptidase_C69; cl17793 401473000539 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 401473000540 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473000541 active site 401473000542 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473000543 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473000544 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 401473000545 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 401473000546 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 401473000547 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 401473000548 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 401473000549 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 401473000550 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 401473000551 Nitrogen regulatory protein P-II; Region: P-II; smart00938 401473000552 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 401473000553 metal binding triad; other site 401473000554 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 401473000555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 401473000556 replicative DNA helicase; Region: DnaB; TIGR00665 401473000557 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 401473000558 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 401473000559 Walker A motif; other site 401473000560 ATP binding site [chemical binding]; other site 401473000561 Walker B motif; other site 401473000562 DNA binding loops [nucleotide binding] 401473000563 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401473000564 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 401473000565 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 401473000566 catalytic triad [active] 401473000567 Uncharacterized conserved protein [Function unknown]; Region: COG3937 401473000568 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 401473000569 ABC1 family; Region: ABC1; cl17513 401473000570 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 401473000571 active site 401473000572 catalytic site [active] 401473000573 Cna protein B-type domain; Region: Cna_B; pfam05738 401473000574 Cna protein B-type domain; Region: Cna_B; pfam05738 401473000575 T surface-antigen of pili; Region: FctA; pfam12892 401473000576 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 401473000577 T surface-antigen of pili; Region: FctA; cl16948 401473000578 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 401473000579 Cna protein B-type domain; Region: Cna_B; pfam05738 401473000580 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 401473000581 active site 401473000582 catalytic site [active] 401473000583 Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009 401473000584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401473000585 active site 401473000586 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 401473000587 active site 401473000588 Ap6A binding site [chemical binding]; other site 401473000589 nudix motif; other site 401473000590 metal binding site [ion binding]; metal-binding site 401473000591 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473000592 catalytic core [active] 401473000593 polyphosphate kinase; Provisional; Region: PRK05443 401473000594 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 401473000595 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 401473000596 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 401473000597 putative domain interface [polypeptide binding]; other site 401473000598 putative active site [active] 401473000599 catalytic site [active] 401473000600 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 401473000601 putative domain interface [polypeptide binding]; other site 401473000602 putative active site [active] 401473000603 catalytic site [active] 401473000604 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473000605 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473000606 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 401473000607 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 401473000608 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 401473000609 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473000610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473000611 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473000612 putative substrate translocation pore; other site 401473000613 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 401473000614 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 401473000615 ATP binding site [chemical binding]; other site 401473000616 Walker A motif; other site 401473000617 hexamer interface [polypeptide binding]; other site 401473000618 Walker B motif; other site 401473000619 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 401473000620 Protein of unknown function (DUF4244); Region: DUF4244; pfam14029 401473000621 helicase/secretion neighborhood TadE-like protein; Region: tadE_like_DECH; TIGR03816 401473000622 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 401473000623 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473000624 active site 401473000625 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 401473000626 phosphorylation site [posttranslational modification] 401473000627 intermolecular recognition site; other site 401473000628 dimerization interface [polypeptide binding]; other site 401473000629 LytTr DNA-binding domain; Region: LytTR; pfam04397 401473000630 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 401473000631 ATP binding site [chemical binding]; other site 401473000632 Mg2+ binding site [ion binding]; other site 401473000633 G-X-G motif; other site 401473000634 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 401473000635 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473000636 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 401473000637 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 401473000638 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 401473000639 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 401473000640 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 401473000641 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473000642 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473000643 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 401473000644 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401473000645 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 401473000646 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401473000647 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 401473000648 Melibiase; Region: Melibiase; pfam02065 401473000649 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07764 401473000650 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473000651 Walker A motif; other site 401473000652 ATP binding site [chemical binding]; other site 401473000653 Walker B motif; other site 401473000654 arginine finger; other site 401473000655 recombination protein RecR; Reviewed; Region: recR; PRK00076 401473000656 RecR protein; Region: RecR; pfam02132 401473000657 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 401473000658 putative active site [active] 401473000659 putative metal-binding site [ion binding]; other site 401473000660 tetramer interface [polypeptide binding]; other site 401473000661 aspartate kinase; Reviewed; Region: PRK06635 401473000662 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 401473000663 putative nucleotide binding site [chemical binding]; other site 401473000664 putative catalytic residues [active] 401473000665 putative Mg ion binding site [ion binding]; other site 401473000666 putative aspartate binding site [chemical binding]; other site 401473000667 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 401473000668 putative allosteric regulatory site; other site 401473000669 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 401473000670 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK08664 401473000671 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 401473000672 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 401473000673 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 401473000674 metal binding site [ion binding]; metal-binding site 401473000675 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 401473000676 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 401473000677 2-isopropylmalate synthase; Validated; Region: PRK03739 401473000678 Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942 401473000679 active site 401473000680 catalytic residues [active] 401473000681 metal binding site [ion binding]; metal-binding site 401473000682 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 401473000683 Glycosyl hydrolase family 43; Region: GH43_ABN_1; cd08998 401473000684 substrate binding site [chemical binding]; other site 401473000685 active site 401473000686 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 401473000687 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 401473000688 active site 401473000689 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473000690 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473000691 DNA binding site [nucleotide binding] 401473000692 domain linker motif; other site 401473000693 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473000694 dimerization interface [polypeptide binding]; other site 401473000695 ligand binding site [chemical binding]; other site 401473000696 Glycosyl hydrolase family 43; Region: GH43_1; cd08980 401473000697 active site 401473000698 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473000699 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 401473000700 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473000701 dimer interface [polypeptide binding]; other site 401473000702 conserved gate region; other site 401473000703 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 401473000704 ABC-ATPase subunit interface; other site 401473000705 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473000706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473000707 dimer interface [polypeptide binding]; other site 401473000708 conserved gate region; other site 401473000709 ABC-ATPase subunit interface; other site 401473000710 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 401473000711 active site 401473000712 Transglycosylase; Region: Transgly; pfam00912 401473000713 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 401473000714 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 401473000715 Myo-inositol-1-phosphate synthase [Lipid metabolism]; Region: INO1; COG1260 401473000716 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; cl00554 401473000717 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 401473000718 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 401473000719 UDP-galactopyranose mutase; Region: GLF; pfam03275 401473000720 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 401473000721 active site 401473000722 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 401473000723 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 401473000724 active site 401473000725 interdomain interaction site; other site 401473000726 putative metal-binding site [ion binding]; other site 401473000727 nucleotide binding site [chemical binding]; other site 401473000728 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 401473000729 domain I; other site 401473000730 phosphate binding site [ion binding]; other site 401473000731 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 401473000732 domain II; other site 401473000733 domain III; other site 401473000734 nucleotide binding site [chemical binding]; other site 401473000735 DNA binding groove [nucleotide binding] 401473000736 catalytic site [active] 401473000737 domain IV; other site 401473000738 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 401473000739 thymidylate kinase; Validated; Region: tmk; PRK00698 401473000740 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 401473000741 TMP-binding site; other site 401473000742 ATP-binding site [chemical binding]; other site 401473000743 DNA polymerase III subunit delta'; Validated; Region: PRK07940 401473000744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473000745 Walker A motif; other site 401473000746 ATP binding site [chemical binding]; other site 401473000747 Walker B motif; other site 401473000748 arginine finger; other site 401473000749 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473000750 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473000751 DNA binding site [nucleotide binding] 401473000752 domain linker motif; other site 401473000753 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473000754 dimerization interface [polypeptide binding]; other site 401473000755 ligand binding site [chemical binding]; other site 401473000756 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 401473000757 dimerization domain swap beta strand [polypeptide binding]; other site 401473000758 regulatory protein interface [polypeptide binding]; other site 401473000759 active site 401473000760 regulatory phosphorylation site [posttranslational modification]; other site 401473000761 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 401473000762 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 401473000763 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 401473000764 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 401473000765 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 401473000766 substrate binding site [chemical binding]; other site 401473000767 Peptidase family C69; Region: Peptidase_C69; pfam03577 401473000768 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 401473000769 macrophage migration inhibitory factor-like protein; Provisional; Region: PTZ00450 401473000770 Predicted membrane protein [Function unknown]; Region: COG2246 401473000771 GtrA-like protein; Region: GtrA; pfam04138 401473000772 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473000773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473000774 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473000775 catalytic core [active] 401473000776 Protein of unknown function (DUF805); Region: DUF805; pfam05656 401473000777 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 401473000778 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 401473000779 HIGH motif; other site 401473000780 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 401473000781 active site 401473000782 KMSKS motif; other site 401473000783 Saccharomyces cerevisiae DCR2 phosphatase and related proteins, metallophosphatase domain; Region: MPP_Dcr2; cd07383 401473000784 putative active site [active] 401473000785 putative metal binding site [ion binding]; other site 401473000786 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 401473000787 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 401473000788 Transcriptional regulator [Transcription]; Region: IclR; COG1414 401473000789 Bacterial transcriptional regulator; Region: IclR; pfam01614 401473000790 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 401473000791 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 401473000792 substrate binding site [chemical binding]; other site 401473000793 ligand binding site [chemical binding]; other site 401473000794 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 401473000795 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 401473000796 substrate binding site [chemical binding]; other site 401473000797 Divergent AAA domain; Region: AAA_4; pfam04326 401473000798 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 401473000799 Response regulator receiver domain; Region: Response_reg; pfam00072 401473000800 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473000801 active site 401473000802 phosphorylation site [posttranslational modification] 401473000803 intermolecular recognition site; other site 401473000804 dimerization interface [polypeptide binding]; other site 401473000805 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 401473000806 Histidine kinase; Region: His_kinase; pfam06580 401473000807 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473000808 ATP binding site [chemical binding]; other site 401473000809 Mg2+ binding site [ion binding]; other site 401473000810 G-X-G motif; other site 401473000811 Dihydroorotate dehydrogenase (DHOD) and Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the...; Region: DHOD_DHPD_FMN; cd02810 401473000812 active site 401473000813 FMN binding site [chemical binding]; other site 401473000814 substrate binding site [chemical binding]; other site 401473000815 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 401473000816 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 401473000817 hinge; other site 401473000818 active site 401473000819 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 401473000820 domain interaction interfaces [polypeptide binding]; other site 401473000821 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 401473000822 Cna protein B-type domain; Region: Cna_B; pfam05738 401473000823 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 401473000824 active site 401473000825 catalytic site [active] 401473000826 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 401473000827 domain interaction interfaces [polypeptide binding]; other site 401473000828 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 401473000829 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 401473000830 putative acyl-acceptor binding pocket; other site 401473000831 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 401473000832 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 401473000833 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 401473000834 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 401473000835 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 401473000836 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401473000837 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 401473000838 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 401473000839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473000840 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473000841 dimer interface [polypeptide binding]; other site 401473000842 conserved gate region; other site 401473000843 putative PBP binding loops; other site 401473000844 ABC-ATPase subunit interface; other site 401473000845 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 401473000846 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473000847 Walker A/P-loop; other site 401473000848 ATP binding site [chemical binding]; other site 401473000849 Q-loop/lid; other site 401473000850 ABC transporter signature motif; other site 401473000851 Walker B; other site 401473000852 D-loop; other site 401473000853 H-loop/switch region; other site 401473000854 CAAX protease self-immunity; Region: Abi; pfam02517 401473000855 Mechanosensitive ion channel; Region: MS_channel; pfam00924 401473000856 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 401473000857 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 401473000858 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 401473000859 Protein of unknown function (DUF2974); Region: DUF2974; pfam11187 401473000860 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473000861 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473000862 aspartate aminotransferase; Provisional; Region: PRK06836 401473000863 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473000864 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473000865 homodimer interface [polypeptide binding]; other site 401473000866 catalytic residue [active] 401473000867 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 401473000868 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490 401473000869 fructuronate transporter; Provisional; Region: PRK10034; cl15264 401473000870 GntP family permease; Region: GntP_permease; pfam02447 401473000871 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 401473000872 AAA domain; Region: AAA_33; pfam13671 401473000873 ATP-binding site [chemical binding]; other site 401473000874 Gluconate-6-phosphate binding site [chemical binding]; other site 401473000875 Transcriptional regulators [Transcription]; Region: FadR; COG2186 401473000876 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 401473000877 DNA-binding site [nucleotide binding]; DNA binding site 401473000878 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 401473000879 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 401473000880 Lipase (class 2); Region: Lipase_2; pfam01674 401473000881 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 401473000882 active site 401473000883 NTP binding site [chemical binding]; other site 401473000884 metal binding triad [ion binding]; metal-binding site 401473000885 Domain of unknown function (DUF4037); Region: DUF4037; pfam13228 401473000886 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 401473000887 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473000888 putative substrate translocation pore; other site 401473000889 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 401473000890 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 401473000891 binding surface 401473000892 TPR motif; other site 401473000893 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 401473000894 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 401473000895 ssDNA binding site; other site 401473000896 generic binding surface II; other site 401473000897 DEAD-like helicases superfamily; Region: DEXDc; smart00487 401473000898 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473000899 ATP binding site [chemical binding]; other site 401473000900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473000901 putative Mg++ binding site [ion binding]; other site 401473000902 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473000903 nucleotide binding region [chemical binding]; other site 401473000904 ATP-binding site [chemical binding]; other site 401473000905 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 401473000906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401473000907 S-adenosylmethionine binding site [chemical binding]; other site 401473000908 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 401473000909 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 401473000910 Aspartase; Region: Aspartase; cd01357 401473000911 active sites [active] 401473000912 tetramer interface [polypeptide binding]; other site 401473000913 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 401473000914 RimM N-terminal domain; Region: RimM; pfam01782 401473000915 hypothetical protein; Provisional; Region: PRK02821 401473000916 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 401473000917 G-X-X-G motif; other site 401473000918 30S ribosomal protein S16; Provisional; Region: rpsP; PRK14520 401473000919 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 401473000920 putative catalytic site [active] 401473000921 putative metal binding site [ion binding]; other site 401473000922 putative phosphate binding site [ion binding]; other site 401473000923 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 401473000924 signal recognition particle protein; Provisional; Region: PRK10867 401473000925 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 401473000926 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 401473000927 P loop; other site 401473000928 GTP binding site [chemical binding]; other site 401473000929 Signal peptide binding domain; Region: SRP_SPB; pfam02978 401473000930 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 401473000931 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401473000932 active site 401473000933 HIGH motif; other site 401473000934 nucleotide binding site [chemical binding]; other site 401473000935 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 401473000936 KMSKS motif; other site 401473000937 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 401473000938 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 401473000939 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 401473000940 catalytic triad [active] 401473000941 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473000942 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401473000943 ABC transporter; Region: ABC_tran_2; pfam12848 401473000944 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473000945 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401473000946 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 401473000947 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 401473000948 putative valine binding site [chemical binding]; other site 401473000949 dimer interface [polypeptide binding]; other site 401473000950 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 401473000951 acetolactate synthase 1 catalytic subunit; Validated; Region: PRK07789 401473000952 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 401473000953 PYR/PP interface [polypeptide binding]; other site 401473000954 dimer interface [polypeptide binding]; other site 401473000955 TPP binding site [chemical binding]; other site 401473000956 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 401473000957 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 401473000958 TPP-binding site [chemical binding]; other site 401473000959 dimer interface [polypeptide binding]; other site 401473000960 ribonuclease III; Reviewed; Region: rnc; PRK00102 401473000961 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 401473000962 dimerization interface [polypeptide binding]; other site 401473000963 active site 401473000964 metal binding site [ion binding]; metal-binding site 401473000965 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 401473000966 dsRNA binding site [nucleotide binding]; other site 401473000967 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 401473000968 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 401473000969 putative mechanosensitive channel protein; Provisional; Region: PRK10929 401473000970 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 401473000971 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 401473000972 active site 401473000973 (T/H)XGH motif; other site 401473000974 Protein of unknown function (DUF3039); Region: DUF3039; pfam11238 401473000975 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401473000976 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 401473000977 active site 401473000978 catalytic tetrad [active] 401473000979 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 401473000980 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 401473000981 DNA binding residues [nucleotide binding] 401473000982 putative dimer interface [polypeptide binding]; other site 401473000983 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 401473000984 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 401473000985 active site 401473000986 ribonuclease PH; Reviewed; Region: rph; PRK00173 401473000987 Ribonuclease PH; Region: RNase_PH_bact; cd11362 401473000988 hexamer interface [polypeptide binding]; other site 401473000989 active site 401473000990 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 401473000991 active site 401473000992 dimerization interface [polypeptide binding]; other site 401473000993 Membrane transport protein; Region: Mem_trans; cl09117 401473000994 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 401473000995 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 401473000996 Substrate binding site; other site 401473000997 Cupin domain; Region: Cupin_2; cl17218 401473000998 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 401473000999 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 401473001000 active site 401473001001 dimer interface [polypeptide binding]; other site 401473001002 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 401473001003 dimer interface [polypeptide binding]; other site 401473001004 active site 401473001005 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 401473001006 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 401473001007 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 401473001008 Catalytic site [active] 401473001009 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 401473001010 RNA/DNA hybrid binding site [nucleotide binding]; other site 401473001011 active site 401473001012 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473001013 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 401473001014 Walker A/P-loop; other site 401473001015 ATP binding site [chemical binding]; other site 401473001016 Q-loop/lid; other site 401473001017 ABC transporter signature motif; other site 401473001018 Walker B; other site 401473001019 D-loop; other site 401473001020 H-loop/switch region; other site 401473001021 Predicted permeases [General function prediction only]; Region: COG0679 401473001022 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13007 401473001023 M20 Peptidase actinobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_actinobac; cd05647 401473001024 metal binding site [ion binding]; metal-binding site 401473001025 putative dimer interface [polypeptide binding]; other site 401473001026 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 401473001027 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 401473001028 homodimer interface [polypeptide binding]; other site 401473001029 oligonucleotide binding site [chemical binding]; other site 401473001030 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 401473001031 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 401473001032 GTPase CgtA; Reviewed; Region: obgE; PRK12296 401473001033 GTP1/OBG; Region: GTP1_OBG; pfam01018 401473001034 Obg GTPase; Region: Obg; cd01898 401473001035 G1 box; other site 401473001036 GTP/Mg2+ binding site [chemical binding]; other site 401473001037 Switch I region; other site 401473001038 G2 box; other site 401473001039 G3 box; other site 401473001040 Switch II region; other site 401473001041 G4 box; other site 401473001042 G5 box; other site 401473001043 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 401473001044 gamma-glutamyl kinase; Provisional; Region: PRK05429 401473001045 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 401473001046 nucleotide binding site [chemical binding]; other site 401473001047 homotetrameric interface [polypeptide binding]; other site 401473001048 putative phosphate binding site [ion binding]; other site 401473001049 putative allosteric binding site; other site 401473001050 PUA domain; Region: PUA; pfam01472 401473001051 aspartate aminotransferase; Provisional; Region: PRK05764 401473001052 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473001053 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473001054 homodimer interface [polypeptide binding]; other site 401473001055 catalytic residue [active] 401473001056 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 401473001057 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 401473001058 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 401473001059 putative homodimer interface [polypeptide binding]; other site 401473001060 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 401473001061 heterodimer interface [polypeptide binding]; other site 401473001062 homodimer interface [polypeptide binding]; other site 401473001063 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 401473001064 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 401473001065 23S rRNA interface [nucleotide binding]; other site 401473001066 L7/L12 interface [polypeptide binding]; other site 401473001067 putative thiostrepton binding site; other site 401473001068 L25 interface [polypeptide binding]; other site 401473001069 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 401473001070 mRNA/rRNA interface [nucleotide binding]; other site 401473001071 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 401473001072 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 401473001073 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 401473001074 BioY family; Region: BioY; pfam02632 401473001075 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 401473001076 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401473001077 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401473001078 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 401473001079 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 401473001080 carboxyltransferase (CT) interaction site; other site 401473001081 biotinylation site [posttranslational modification]; other site 401473001082 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 401473001083 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 401473001084 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 401473001085 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 401473001086 Enoyl reductase domain of yeast-type FAS1 [Lipid metabolism]; Region: COG4981 401473001087 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 401473001088 phosphate binding site [ion binding]; other site 401473001089 Domain of unknown function (DUF1729); Region: DUF1729; pfam08354 401473001090 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 401473001091 active site 2 [active] 401473001092 active site 1 [active] 401473001093 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 401473001094 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 401473001095 3-oxoacyl-[acyl-carrier protein]; Region: COG4982 401473001096 ketoacyl reductase (KR) domain of fungal-type fatty acid synthase (fFAS), classical (c)-like SDRs; Region: KR_fFAS_SDR_c_like; cd08950 401473001097 putative NAD(P) binding site [chemical binding]; other site 401473001098 active site 401473001099 "elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828 401473001100 3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304 401473001101 active site 401473001102 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; cl00500 401473001103 Alpha amylase catalytic domain found in Amylosucrase; Region: AmyAc_Amylosucrase; cd11324 401473001104 trehalose synthase; Region: treS_nterm; TIGR02456 401473001105 active site 401473001106 catalytic site [active] 401473001107 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 401473001108 16S/18S rRNA binding site [nucleotide binding]; other site 401473001109 S13e-L30e interaction site [polypeptide binding]; other site 401473001110 25S rRNA binding site [nucleotide binding]; other site 401473001111 guanosine pentaphosphate synthetase I/polynucleotide phosphorylase; Region: pppGpp_PNP; TIGR02696 401473001112 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 401473001113 oligomer interface [polypeptide binding]; other site 401473001114 RNA binding site [nucleotide binding]; other site 401473001115 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 401473001116 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 401473001117 RNase E interface [polypeptide binding]; other site 401473001118 trimer interface [polypeptide binding]; other site 401473001119 active site 401473001120 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 401473001121 putative nucleic acid binding region [nucleotide binding]; other site 401473001122 G-X-X-G motif; other site 401473001123 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 401473001124 RNA binding site [nucleotide binding]; other site 401473001125 domain interface; other site 401473001126 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 401473001127 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 401473001128 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401473001129 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 401473001130 active site 401473001131 catalytic tetrad [active] 401473001132 LysE type translocator; Region: LysE; cl00565 401473001133 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 401473001134 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 401473001135 DNA-binding site [nucleotide binding]; DNA binding site 401473001136 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473001137 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473001138 homodimer interface [polypeptide binding]; other site 401473001139 catalytic residue [active] 401473001140 putative transporter; Provisional; Region: PRK11021 401473001141 Transmembrane amino acid transporter protein; Region: Aa_trans; cl17468 401473001142 AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_1; cd03137 401473001143 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 401473001144 conserved cys residue [active] 401473001145 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401473001146 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401473001147 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 401473001148 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 401473001149 Peptidase family U32; Region: Peptidase_U32; pfam01136 401473001150 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 401473001151 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 401473001152 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 401473001153 substrate binding site; other site 401473001154 dimer interface; other site 401473001155 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 401473001156 putative substrate binding pocket [chemical binding]; other site 401473001157 AC domain interface; other site 401473001158 catalytic triad [active] 401473001159 AB domain interface; other site 401473001160 interchain disulfide; other site 401473001161 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 401473001162 trimer interface [polypeptide binding]; other site 401473001163 active site 401473001164 G bulge; other site 401473001165 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 401473001166 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 401473001167 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 401473001168 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 401473001169 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 401473001170 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 401473001171 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 401473001172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 401473001173 dimer interface [polypeptide binding]; other site 401473001174 phosphorylation site [posttranslational modification] 401473001175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473001176 ATP binding site [chemical binding]; other site 401473001177 Mg2+ binding site [ion binding]; other site 401473001178 G-X-G motif; other site 401473001179 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 401473001180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473001181 active site 401473001182 phosphorylation site [posttranslational modification] 401473001183 intermolecular recognition site; other site 401473001184 dimerization interface [polypeptide binding]; other site 401473001185 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401473001186 DNA binding site [nucleotide binding] 401473001187 PBP superfamily domain; Region: PBP_like_2; cl17296 401473001188 potential frameshift: common BLAST hit: gi|119025297|ref|YP_909142.1| phosphate ABC transporter permease 401473001189 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473001190 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473001191 ABC-ATPase subunit interface; other site 401473001192 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 401473001193 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473001194 dimer interface [polypeptide binding]; other site 401473001195 conserved gate region; other site 401473001196 putative PBP binding loops; other site 401473001197 ABC-ATPase subunit interface; other site 401473001198 phosphate transporter ATP-binding protein; Provisional; Region: PRK14241 401473001199 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 401473001200 Walker A/P-loop; other site 401473001201 ATP binding site [chemical binding]; other site 401473001202 Q-loop/lid; other site 401473001203 ABC transporter signature motif; other site 401473001204 Walker B; other site 401473001205 D-loop; other site 401473001206 H-loop/switch region; other site 401473001207 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 401473001208 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 401473001209 intersubunit interface [polypeptide binding]; other site 401473001210 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 401473001211 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 401473001212 23S rRNA interface [nucleotide binding]; other site 401473001213 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 401473001214 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 401473001215 peripheral dimer interface [polypeptide binding]; other site 401473001216 core dimer interface [polypeptide binding]; other site 401473001217 L10 interface [polypeptide binding]; other site 401473001218 L11 interface [polypeptide binding]; other site 401473001219 putative EF-Tu interaction site [polypeptide binding]; other site 401473001220 putative EF-G interaction site [polypeptide binding]; other site 401473001221 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 401473001222 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 401473001223 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 401473001224 phosphopeptide binding site; other site 401473001225 Part of AAA domain; Region: AAA_19; pfam13245 401473001226 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 401473001227 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 401473001228 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 401473001229 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 401473001230 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 401473001231 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 401473001232 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 401473001233 oligomerisation interface [polypeptide binding]; other site 401473001234 mobile loop; other site 401473001235 roof hairpin; other site 401473001236 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 401473001237 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401473001238 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401473001239 catalytic residue [active] 401473001240 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 401473001241 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13903 401473001242 FAD binding domain; Region: FAD_binding_4; pfam01565 401473001243 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 401473001244 amino acid transporter; Region: 2A0306; TIGR00909 401473001245 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 401473001246 Ferredoxin [Energy production and conversion]; Region: COG1146 401473001247 4Fe-4S binding domain; Region: Fer4; pfam00037 401473001248 N-succinyldiaminopimelate aminotransferase; Reviewed; Region: PRK07865 401473001249 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473001250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473001251 homodimer interface [polypeptide binding]; other site 401473001252 catalytic residue [active] 401473001253 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 401473001254 active site 401473001255 DNA polymerase IV; Validated; Region: PRK02406 401473001256 DNA binding site [nucleotide binding] 401473001257 Threonine/homoserine efflux transporter [Amino acid transport and metabolism]; Region: rhtA; COG5006 401473001258 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 401473001259 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 401473001260 putative active site [active] 401473001261 putative metal binding site [ion binding]; other site 401473001262 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 401473001263 Putative D-3-Phosphoglycerate Dehydrogenases; Region: PGDH_like_1; cd12169 401473001264 dimerization interface [polypeptide binding]; other site 401473001265 NAD binding site [chemical binding]; other site 401473001266 ligand binding site [chemical binding]; other site 401473001267 catalytic site [active] 401473001268 Uncharacterized conserved protein [Function unknown]; Region: COG1739 401473001269 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 401473001270 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 401473001271 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 401473001272 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 401473001273 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 401473001274 23S rRNA interface [nucleotide binding]; other site 401473001275 L3 interface [polypeptide binding]; other site 401473001276 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 401473001277 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 401473001278 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 401473001279 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 401473001280 active site 401473001281 catalytic site [active] 401473001282 L-threonine dehydrogenase; Region: threonine_DH_like; cd08234 401473001283 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 401473001284 putative NAD(P) binding site [chemical binding]; other site 401473001285 catalytic Zn binding site [ion binding]; other site 401473001286 polyol permease family; Region: 2A0118; TIGR00897 401473001287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473001288 putative substrate translocation pore; other site 401473001289 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 401473001290 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401473001291 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 401473001292 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 401473001293 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 401473001294 putative catalytic cysteine [active] 401473001295 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 401473001296 putative active site [active] 401473001297 metal binding site [ion binding]; metal-binding site 401473001298 YwiC-like protein; Region: YwiC; pfam14256 401473001299 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 401473001300 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 401473001301 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 401473001302 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 401473001303 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 401473001304 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 401473001305 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 401473001306 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 401473001307 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 401473001308 putative translocon binding site; other site 401473001309 protein-rRNA interface [nucleotide binding]; other site 401473001310 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 401473001311 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 401473001312 G-X-X-G motif; other site 401473001313 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 401473001314 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 401473001315 23S rRNA interface [nucleotide binding]; other site 401473001316 5S rRNA interface [nucleotide binding]; other site 401473001317 putative antibiotic binding site [chemical binding]; other site 401473001318 L25 interface [polypeptide binding]; other site 401473001319 L27 interface [polypeptide binding]; other site 401473001320 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 401473001321 23S rRNA interface [nucleotide binding]; other site 401473001322 putative translocon interaction site; other site 401473001323 signal recognition particle (SRP54) interaction site; other site 401473001324 L23 interface [polypeptide binding]; other site 401473001325 trigger factor interaction site; other site 401473001326 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 401473001327 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 401473001328 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 401473001329 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 401473001330 RNA binding site [nucleotide binding]; other site 401473001331 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 401473001332 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 401473001333 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 401473001334 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 401473001335 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 401473001336 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 401473001337 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 401473001338 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 401473001339 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 401473001340 5S rRNA interface [nucleotide binding]; other site 401473001341 L27 interface [polypeptide binding]; other site 401473001342 23S rRNA interface [nucleotide binding]; other site 401473001343 L5 interface [polypeptide binding]; other site 401473001344 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 401473001345 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 401473001346 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 401473001347 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 401473001348 23S rRNA binding site [nucleotide binding]; other site 401473001349 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 401473001350 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 401473001351 SecY translocase; Region: SecY; pfam00344 401473001352 adenylate kinase; Reviewed; Region: adk; PRK00279 401473001353 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 401473001354 AMP-binding site [chemical binding]; other site 401473001355 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 401473001356 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 401473001357 rRNA binding site [nucleotide binding]; other site 401473001358 predicted 30S ribosome binding site; other site 401473001359 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 401473001360 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 401473001361 30S ribosomal protein S13; Region: bact_S13; TIGR03631 401473001362 30S ribosomal protein S11; Validated; Region: PRK05309 401473001363 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 401473001364 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 401473001365 alphaNTD homodimer interface [polypeptide binding]; other site 401473001366 alphaNTD - beta interaction site [polypeptide binding]; other site 401473001367 alphaNTD - beta' interaction site [polypeptide binding]; other site 401473001368 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 401473001369 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 401473001370 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 401473001371 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 401473001372 dimerization interface 3.5A [polypeptide binding]; other site 401473001373 active site 401473001374 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 401473001375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 401473001376 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 401473001377 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 401473001378 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 401473001379 7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402 401473001380 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 401473001381 NusA N-terminal domain; Region: NusA_N; pfam08529 401473001382 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 401473001383 RNA binding site [nucleotide binding]; other site 401473001384 homodimer interface [polypeptide binding]; other site 401473001385 NusA-like KH domain; Region: KH_5; pfam13184 401473001386 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 401473001387 G-X-X-G motif; other site 401473001388 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 401473001389 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 401473001390 Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532 401473001391 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 401473001392 G1 box; other site 401473001393 putative GEF interaction site [polypeptide binding]; other site 401473001394 GTP/Mg2+ binding site [chemical binding]; other site 401473001395 Switch I region; other site 401473001396 G2 box; other site 401473001397 G3 box; other site 401473001398 Switch II region; other site 401473001399 G4 box; other site 401473001400 G5 box; other site 401473001401 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 401473001402 Translation-initiation factor 2; Region: IF-2; pfam11987 401473001403 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 401473001404 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 401473001405 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK03287 401473001406 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 401473001407 RNA binding site [nucleotide binding]; other site 401473001408 active site 401473001409 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 401473001410 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 401473001411 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401473001412 active site 401473001413 nucleotide binding site [chemical binding]; other site 401473001414 HIGH motif; other site 401473001415 KMSKS motif; other site 401473001416 Riboflavin kinase; Region: Flavokinase; smart00904 401473001417 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 401473001418 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473001419 Walker A/P-loop; other site 401473001420 ATP binding site [chemical binding]; other site 401473001421 Q-loop/lid; other site 401473001422 ABC transporter signature motif; other site 401473001423 Walker B; other site 401473001424 D-loop; other site 401473001425 H-loop/switch region; other site 401473001426 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 401473001427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473001428 dimer interface [polypeptide binding]; other site 401473001429 conserved gate region; other site 401473001430 putative PBP binding loops; other site 401473001431 ABC-ATPase subunit interface; other site 401473001432 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401473001433 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 401473001434 substrate binding pocket [chemical binding]; other site 401473001435 membrane-bound complex binding site; other site 401473001436 hinge residues; other site 401473001437 Cupin superfamily (DUF985); Region: Cupin_5; pfam06172 401473001438 Cytosine deaminase and related metal-dependent hydrolases [Nucleotide transport and metabolism / General function prediction only]; Region: SsnA; COG0402 401473001439 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 401473001440 active site 401473001441 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 401473001442 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 401473001443 NAD binding site [chemical binding]; other site 401473001444 DNA repair protein RadA; Provisional; Region: PRK11823 401473001445 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 401473001446 Walker A motif; other site 401473001447 ATP binding site [chemical binding]; other site 401473001448 Walker B motif; other site 401473001449 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 401473001450 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401473001451 active site 401473001452 dimer interface [polypeptide binding]; other site 401473001453 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 401473001454 RNA/DNA hybrid binding site [nucleotide binding]; other site 401473001455 active site 401473001456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 401473001457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473001458 ATP binding site [chemical binding]; other site 401473001459 Mg2+ binding site [ion binding]; other site 401473001460 G-X-G motif; other site 401473001461 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 401473001462 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473001463 active site 401473001464 phosphorylation site [posttranslational modification] 401473001465 intermolecular recognition site; other site 401473001466 dimerization interface [polypeptide binding]; other site 401473001467 LytTr DNA-binding domain; Region: LytTR; smart00850 401473001468 phosphoglucomutase; Validated; Region: PRK07564 401473001469 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 401473001470 active site 401473001471 substrate binding site [chemical binding]; other site 401473001472 metal binding site [ion binding]; metal-binding site 401473001473 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 401473001474 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 401473001475 active site turn [active] 401473001476 phosphorylation site [posttranslational modification] 401473001477 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 401473001478 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 401473001479 HPr interaction site; other site 401473001480 glycerol kinase (GK) interaction site [polypeptide binding]; other site 401473001481 active site 401473001482 phosphorylation site [posttranslational modification] 401473001483 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 401473001484 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 401473001485 seryl-tRNA synthetase; Provisional; Region: PRK05431 401473001486 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 401473001487 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 401473001488 dimer interface [polypeptide binding]; other site 401473001489 active site 401473001490 motif 1; other site 401473001491 motif 2; other site 401473001492 motif 3; other site 401473001493 Melibiase; Region: Melibiase; pfam02065 401473001494 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473001495 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473001496 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 401473001497 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473001498 dimer interface [polypeptide binding]; other site 401473001499 conserved gate region; other site 401473001500 putative PBP binding loops; other site 401473001501 ABC-ATPase subunit interface; other site 401473001502 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473001503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473001504 dimer interface [polypeptide binding]; other site 401473001505 conserved gate region; other site 401473001506 putative PBP binding loops; other site 401473001507 ABC-ATPase subunit interface; other site 401473001508 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473001509 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473001510 DNA binding site [nucleotide binding] 401473001511 domain linker motif; other site 401473001512 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 401473001513 ligand binding site [chemical binding]; other site 401473001514 dimerization interface (open form) [polypeptide binding]; other site 401473001515 dimerization interface (closed form) [polypeptide binding]; other site 401473001516 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 401473001517 Uncharacterized conserved protein [Function unknown]; Region: COG1434 401473001518 putative active site [active] 401473001519 Phosphotransferase enzyme family; Region: APH; pfam01636 401473001520 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 401473001521 active site 401473001522 ATP binding site [chemical binding]; other site 401473001523 ethanolamine permease; Region: 2A0305; TIGR00908 401473001524 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 401473001525 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 401473001526 inhibitor-cofactor binding pocket; inhibition site 401473001527 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473001528 catalytic residue [active] 401473001529 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 401473001530 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 401473001531 DNA-binding site [nucleotide binding]; DNA binding site 401473001532 UTRA domain; Region: UTRA; pfam07702 401473001533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 401473001534 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473001535 active site 401473001536 phosphorylation site [posttranslational modification] 401473001537 intermolecular recognition site; other site 401473001538 dimerization interface [polypeptide binding]; other site 401473001539 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 401473001540 DNA binding residues [nucleotide binding] 401473001541 dimerization interface [polypeptide binding]; other site 401473001542 PspC domain; Region: PspC; pfam04024 401473001543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 401473001544 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473001545 ATP binding site [chemical binding]; other site 401473001546 Mg2+ binding site [ion binding]; other site 401473001547 G-X-G motif; other site 401473001548 PspC domain; Region: PspC; pfam04024 401473001549 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 401473001550 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401473001551 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401473001552 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473001553 Walker A/P-loop; other site 401473001554 ATP binding site [chemical binding]; other site 401473001555 Q-loop/lid; other site 401473001556 ABC transporter signature motif; other site 401473001557 Walker B; other site 401473001558 D-loop; other site 401473001559 H-loop/switch region; other site 401473001560 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401473001561 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401473001562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473001563 Walker A/P-loop; other site 401473001564 ATP binding site [chemical binding]; other site 401473001565 Q-loop/lid; other site 401473001566 ABC transporter signature motif; other site 401473001567 Walker B; other site 401473001568 D-loop; other site 401473001569 H-loop/switch region; other site 401473001570 MFS transport protein AraJ; Provisional; Region: PRK10091 401473001571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473001572 putative substrate translocation pore; other site 401473001573 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 401473001574 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473001575 active site 401473001576 phosphorylation site [posttranslational modification] 401473001577 intermolecular recognition site; other site 401473001578 dimerization interface [polypeptide binding]; other site 401473001579 LytTr DNA-binding domain; Region: LytTR; pfam04397 401473001580 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 401473001581 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 401473001582 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473001583 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 401473001584 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 401473001585 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 401473001586 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 401473001587 dimer interface [polypeptide binding]; other site 401473001588 putative anticodon binding site; other site 401473001589 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 401473001590 motif 1; other site 401473001591 dimer interface [polypeptide binding]; other site 401473001592 active site 401473001593 motif 2; other site 401473001594 motif 3; other site 401473001595 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080 401473001596 UbiA prenyltransferase family; Region: UbiA; pfam01040 401473001597 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473001598 catalytic core [active] 401473001599 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 401473001600 myosin-cross-reactive antigen; Provisional; Region: PRK13977 401473001601 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 401473001602 PhoU domain; Region: PhoU; pfam01895 401473001603 PhoU domain; Region: PhoU; pfam01895 401473001604 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 401473001605 dimer interface [polypeptide binding]; other site 401473001606 phosphorylation site [posttranslational modification] 401473001607 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473001608 ATP binding site [chemical binding]; other site 401473001609 Mg2+ binding site [ion binding]; other site 401473001610 G-X-G motif; other site 401473001611 plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647 401473001612 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 401473001613 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 401473001614 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 401473001615 phosphoserine aminotransferase; Provisional; Region: PRK03080 401473001616 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401473001617 catalytic residue [active] 401473001618 CHAP domain; Region: CHAP; pfam05257 401473001619 NlpC/P60 family; Region: NLPC_P60; pfam00877 401473001620 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 401473001621 Ligand Binding Site [chemical binding]; other site 401473001622 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 401473001623 Ligand Binding Site [chemical binding]; other site 401473001624 OsmC-like protein; Region: OsmC; pfam02566 401473001625 thymidylate synthase; Reviewed; Region: thyA; PRK01827 401473001626 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 401473001627 dimerization interface [polypeptide binding]; other site 401473001628 active site 401473001629 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 401473001630 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 401473001631 folate binding site [chemical binding]; other site 401473001632 NADP+ binding site [chemical binding]; other site 401473001633 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 401473001634 Low molecular weight phosphatase family; Region: LMWPc; cd00115 401473001635 active site 401473001636 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 401473001637 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 401473001638 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401473001639 NAD(P) binding site [chemical binding]; other site 401473001640 active site 401473001641 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 401473001642 Cna protein B-type domain; Region: Cna_B; pfam05738 401473001643 Cna protein B-type domain; Region: Cna_B; pfam05738 401473001644 Cna protein B-type domain; Region: Cna_B; pfam05738 401473001645 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 401473001646 Cna protein B-type domain; Region: Cna_B; pfam05738 401473001647 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 401473001648 active site 401473001649 catalytic site [active] 401473001650 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 401473001651 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 401473001652 dimer interface [polypeptide binding]; other site 401473001653 active site 401473001654 metal binding site [ion binding]; metal-binding site 401473001655 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 401473001656 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473001657 active site 401473001658 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 401473001659 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 401473001660 Domain of unknown function DUF20; Region: UPF0118; pfam01594 401473001661 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 401473001662 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 401473001663 DXD motif; other site 401473001664 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 401473001665 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 401473001666 Walker A/P-loop; other site 401473001667 ATP binding site [chemical binding]; other site 401473001668 Q-loop/lid; other site 401473001669 ABC transporter signature motif; other site 401473001670 Walker B; other site 401473001671 D-loop; other site 401473001672 H-loop/switch region; other site 401473001673 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 401473001674 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 401473001675 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 401473001676 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 401473001677 Ligand Binding Site [chemical binding]; other site 401473001678 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401473001679 active site 401473001680 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 401473001681 Preprotein translocase subunit; Region: YajC; cl00806 401473001682 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473001683 Walker A motif; other site 401473001684 ATP binding site [chemical binding]; other site 401473001685 Walker B motif; other site 401473001686 arginine finger; other site 401473001687 Peptidase family M41; Region: Peptidase_M41; pfam01434 401473001688 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 401473001689 homodecamer interface [polypeptide binding]; other site 401473001690 GTP cyclohydrolase I; Provisional; Region: PLN03044 401473001691 active site 401473001692 putative catalytic site residues [active] 401473001693 zinc binding site [ion binding]; other site 401473001694 GTP-CH-I/GFRP interaction surface; other site 401473001695 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 401473001696 dihydropteroate synthase; Region: DHPS; TIGR01496 401473001697 substrate binding pocket [chemical binding]; other site 401473001698 dimer interface [polypeptide binding]; other site 401473001699 inhibitor binding site; inhibition site 401473001700 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 401473001701 homooctamer interface [polypeptide binding]; other site 401473001702 active site 401473001703 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 401473001704 catalytic center binding site [active] 401473001705 ATP binding site [chemical binding]; other site 401473001706 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cl00233 401473001707 catalytic center binding site [active] 401473001708 ATP binding site [chemical binding]; other site 401473001709 Protein of unknown function (DUF3180); Region: DUF3180; pfam11377 401473001710 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 401473001711 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 401473001712 active site 401473001713 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 401473001714 catalytic triad [active] 401473001715 dimer interface [polypeptide binding]; other site 401473001716 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 401473001717 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473001718 Walker A/P-loop; other site 401473001719 ATP binding site [chemical binding]; other site 401473001720 Q-loop/lid; other site 401473001721 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401473001722 ABC transporter; Region: ABC_tran_2; pfam12848 401473001723 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401473001724 Beta-lactamase; Region: Beta-lactamase; pfam00144 401473001725 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 401473001726 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 401473001727 active site 401473001728 catalytic residues [active] 401473001729 metal binding site [ion binding]; metal-binding site 401473001730 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 401473001731 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 401473001732 active site 401473001733 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 401473001734 putative active site [active] 401473001735 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 401473001736 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 401473001737 homodimer interface [polypeptide binding]; other site 401473001738 substrate-cofactor binding pocket; other site 401473001739 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473001740 catalytic residue [active] 401473001741 xylose isomerase; Provisional; Region: PRK05474 401473001742 xylose isomerase; Region: xylose_isom_A; TIGR02630 401473001743 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 401473001744 active site 401473001745 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473001746 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473001747 DNA binding site [nucleotide binding] 401473001748 domain linker motif; other site 401473001749 Ligand-binding domain of a LacI-like transcriptional regulator, CatR which is involved in catechol degradation; Region: PBP1_CatR_like; cd06296 401473001750 putative dimerization interface [polypeptide binding]; other site 401473001751 putative ligand binding site [chemical binding]; other site 401473001752 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473001753 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473001754 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 401473001755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473001756 dimer interface [polypeptide binding]; other site 401473001757 conserved gate region; other site 401473001758 putative PBP binding loops; other site 401473001759 ABC-ATPase subunit interface; other site 401473001760 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473001761 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473001762 dimer interface [polypeptide binding]; other site 401473001763 conserved gate region; other site 401473001764 putative PBP binding loops; other site 401473001765 ABC-ATPase subunit interface; other site 401473001766 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 401473001767 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 401473001768 inhibitor binding site; inhibition site 401473001769 active site 401473001770 Protein of unknown function (DUF1349); Region: DUF1349; cl01397 401473001771 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 401473001772 trimer interface [polypeptide binding]; other site 401473001773 active site 401473001774 substrate binding site [chemical binding]; other site 401473001775 CoA binding site [chemical binding]; other site 401473001776 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 401473001777 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 401473001778 putative ligand binding site [chemical binding]; other site 401473001779 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 401473001780 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 401473001781 Walker A/P-loop; other site 401473001782 ATP binding site [chemical binding]; other site 401473001783 Q-loop/lid; other site 401473001784 ABC transporter signature motif; other site 401473001785 Walker B; other site 401473001786 D-loop; other site 401473001787 H-loop/switch region; other site 401473001788 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 401473001789 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 401473001790 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 401473001791 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 401473001792 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 401473001793 TM-ABC transporter signature motif; other site 401473001794 D-xylulose kinases, subgroup 1; members of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_1; cd07809 401473001795 N- and C-terminal domain interface [polypeptide binding]; other site 401473001796 D-xylulose kinase; Region: XylB; TIGR01312 401473001797 active site 401473001798 MgATP binding site [chemical binding]; other site 401473001799 catalytic site [active] 401473001800 metal binding site [ion binding]; metal-binding site 401473001801 xylulose binding site [chemical binding]; other site 401473001802 putative homodimer interface [polypeptide binding]; other site 401473001803 Bdent1; attR/attL site 401473001804 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401473001805 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 401473001806 Helix-turn-helix domain; Region: HTH_17; pfam12728 401473001807 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 401473001808 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 401473001809 active site 401473001810 Phage Terminase; Region: Terminase_1; pfam03354 401473001811 Phage-related protein [Function unknown]; Region: COG4695; cl01923 401473001812 Phage portal protein; Region: Phage_portal; pfam04860 401473001813 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 401473001814 Phage capsid family; Region: Phage_capsid; pfam05065 401473001815 tape measure domain; Region: tape_meas_nterm; TIGR02675 401473001816 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 401473001817 active site 401473001818 catalytic triad [active] 401473001819 oxyanion hole [active] 401473001820 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 401473001821 active site 401473001822 DNA binding site [nucleotide binding] 401473001823 Int/Topo IB signature motif; other site 401473001824 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 401473001825 peptide chain release factor 1; Validated; Region: prfA; PRK00591 401473001826 PCRF domain; Region: PCRF; pfam03462 401473001827 RF-1 domain; Region: RF-1; pfam00472 401473001828 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 401473001829 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401473001830 S-adenosylmethionine binding site [chemical binding]; other site 401473001831 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 401473001832 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 401473001833 putative ligand binding site [chemical binding]; other site 401473001834 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 401473001835 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 401473001836 TM-ABC transporter signature motif; other site 401473001837 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 401473001838 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 401473001839 TM-ABC transporter signature motif; other site 401473001840 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 401473001841 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 401473001842 Walker A/P-loop; other site 401473001843 ATP binding site [chemical binding]; other site 401473001844 Q-loop/lid; other site 401473001845 ABC transporter signature motif; other site 401473001846 Walker B; other site 401473001847 D-loop; other site 401473001848 H-loop/switch region; other site 401473001849 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 401473001850 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 401473001851 Walker A/P-loop; other site 401473001852 ATP binding site [chemical binding]; other site 401473001853 Q-loop/lid; other site 401473001854 ABC transporter signature motif; other site 401473001855 Walker B; other site 401473001856 D-loop; other site 401473001857 H-loop/switch region; other site 401473001858 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 401473001859 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 401473001860 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 401473001861 Mg++ binding site [ion binding]; other site 401473001862 putative catalytic motif [active] 401473001863 substrate binding site [chemical binding]; other site 401473001864 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 401473001865 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 401473001866 Int/Topo IB signature motif; other site 401473001867 Protein of unknown function (DUF3631); Region: DUF3631; pfam12307 401473001868 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 401473001869 Phage capsid family; Region: Phage_capsid; pfam05065 401473001870 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 401473001871 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 401473001872 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 401473001873 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 401473001874 active site 401473001875 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 401473001876 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473001877 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473001878 DNA binding site [nucleotide binding] 401473001879 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473001880 ligand binding site [chemical binding]; other site 401473001881 dimerization interface [polypeptide binding]; other site 401473001882 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 401473001883 active site 401473001884 catalytic site [active] 401473001885 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 401473001886 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473001887 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473001888 putative substrate translocation pore; other site 401473001889 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 401473001890 catalytic site [active] 401473001891 putative active site [active] 401473001892 putative substrate binding site [chemical binding]; other site 401473001893 dimer interface [polypeptide binding]; other site 401473001894 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 401473001895 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473001896 active site 401473001897 motif I; other site 401473001898 motif II; other site 401473001899 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473001900 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473001901 PIF1-like helicase; Region: PIF1; pfam05970 401473001902 Walker A motif; other site 401473001903 ATP binding site [chemical binding]; other site 401473001904 Walker B motif; other site 401473001905 arginine finger; other site 401473001906 prolyl-tRNA synthetase; Provisional; Region: PRK09194 401473001907 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 401473001908 dimer interface [polypeptide binding]; other site 401473001909 motif 1; other site 401473001910 active site 401473001911 motif 2; other site 401473001912 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 401473001913 putative deacylase active site [active] 401473001914 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 401473001915 active site 401473001916 motif 3; other site 401473001917 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 401473001918 anticodon binding site; other site 401473001919 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 401473001920 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 401473001921 ssDNA binding site [nucleotide binding]; other site 401473001922 dimer interface [polypeptide binding]; other site 401473001923 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401473001924 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 401473001925 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 401473001926 active site 401473001927 Zn binding site [ion binding]; other site 401473001928 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 401473001929 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 401473001930 active site 401473001931 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 401473001932 Citrate synthase; Region: Citrate_synt; pfam00285 401473001933 oxalacetate binding site [chemical binding]; other site 401473001934 citrylCoA binding site [chemical binding]; other site 401473001935 coenzyme A binding site [chemical binding]; other site 401473001936 catalytic triad [active] 401473001937 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 401473001938 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_actino; TIGR03535 401473001939 Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649 401473001940 putative trimer interface [polypeptide binding]; other site 401473001941 putative CoA binding site [chemical binding]; other site 401473001942 peptide chain release factor 2; Validated; Region: prfB; PRK00578 401473001943 This domain is found in peptide chain release factors; Region: PCRF; smart00937 401473001944 RF-1 domain; Region: RF-1; pfam00472 401473001945 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 401473001946 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473001947 Walker A/P-loop; other site 401473001948 ATP binding site [chemical binding]; other site 401473001949 Q-loop/lid; other site 401473001950 ABC transporter signature motif; other site 401473001951 Walker B; other site 401473001952 D-loop; other site 401473001953 H-loop/switch region; other site 401473001954 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 401473001955 CHAP domain; Region: CHAP; pfam05257 401473001956 Surface antigen [General function prediction only]; Region: COG3942 401473001957 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 401473001958 SmpB-tmRNA interface; other site 401473001959 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401473001960 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 401473001961 substrate binding pocket [chemical binding]; other site 401473001962 membrane-bound complex binding site; other site 401473001963 hinge residues; other site 401473001964 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401473001965 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 401473001966 substrate binding pocket [chemical binding]; other site 401473001967 membrane-bound complex binding site; other site 401473001968 hinge residues; other site 401473001969 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473001970 dimer interface [polypeptide binding]; other site 401473001971 conserved gate region; other site 401473001972 putative PBP binding loops; other site 401473001973 ABC-ATPase subunit interface; other site 401473001974 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 401473001975 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 401473001976 Walker A/P-loop; other site 401473001977 ATP binding site [chemical binding]; other site 401473001978 Q-loop/lid; other site 401473001979 ABC transporter signature motif; other site 401473001980 Walker B; other site 401473001981 D-loop; other site 401473001982 H-loop/switch region; other site 401473001983 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 401473001984 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 401473001985 glutaminase active site [active] 401473001986 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 401473001987 dimer interface [polypeptide binding]; other site 401473001988 active site 401473001989 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 401473001990 dimer interface [polypeptide binding]; other site 401473001991 active site 401473001992 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 401473001993 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 401473001994 active site 401473001995 serine/threonine transporter SstT; Provisional; Region: PRK13628 401473001996 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 401473001997 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473001998 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 401473001999 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473002000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002001 dimer interface [polypeptide binding]; other site 401473002002 conserved gate region; other site 401473002003 putative PBP binding loops; other site 401473002004 ABC-ATPase subunit interface; other site 401473002005 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473002006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002007 dimer interface [polypeptide binding]; other site 401473002008 conserved gate region; other site 401473002009 putative PBP binding loops; other site 401473002010 ABC-ATPase subunit interface; other site 401473002011 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 401473002012 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 401473002013 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 401473002014 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 401473002015 Alpha-L-arabinofuranosidase [Carbohydrate transport and metabolism]; Region: AbfA; COG3534 401473002016 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; pfam06964 401473002017 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473002018 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 401473002019 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473002020 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473002021 pantothenate kinase; Reviewed; Region: PRK13318 401473002022 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 401473002023 Flavoprotein; Region: Flavoprotein; pfam02441 401473002024 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 401473002025 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 401473002026 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 401473002027 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 401473002028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473002029 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473002030 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 401473002031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002032 dimer interface [polypeptide binding]; other site 401473002033 conserved gate region; other site 401473002034 putative PBP binding loops; other site 401473002035 ABC-ATPase subunit interface; other site 401473002036 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 401473002037 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 401473002038 Walker A/P-loop; other site 401473002039 ATP binding site [chemical binding]; other site 401473002040 Q-loop/lid; other site 401473002041 ABC transporter signature motif; other site 401473002042 Walker B; other site 401473002043 D-loop; other site 401473002044 H-loop/switch region; other site 401473002045 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 401473002046 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 401473002047 Walker A/P-loop; other site 401473002048 ATP binding site [chemical binding]; other site 401473002049 Q-loop/lid; other site 401473002050 ABC transporter signature motif; other site 401473002051 Walker B; other site 401473002052 D-loop; other site 401473002053 H-loop/switch region; other site 401473002054 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 401473002055 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 401473002056 dimer interface [polypeptide binding]; other site 401473002057 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473002058 catalytic residue [active] 401473002059 potential frameshift: common BLAST hit: gi|119025509|ref|YP_909354.1| cystathionine gamma-synthase 401473002060 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401473002061 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401473002062 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401473002063 catalytic residue [active] 401473002064 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 401473002065 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473002066 ATP binding site [chemical binding]; other site 401473002067 putative Mg++ binding site [ion binding]; other site 401473002068 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473002069 nucleotide binding region [chemical binding]; other site 401473002070 ATP-binding site [chemical binding]; other site 401473002071 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 401473002072 HRDC domain; Region: HRDC; pfam00570 401473002073 S-ribosylhomocysteinase; Provisional; Region: PRK02260 401473002074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 401473002075 amino acid transporter; Region: 2A0306; TIGR00909 401473002076 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 401473002077 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 401473002078 alanine racemase; Reviewed; Region: alr; PRK00053 401473002079 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 401473002080 active site 401473002081 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401473002082 dimer interface [polypeptide binding]; other site 401473002083 substrate binding site [chemical binding]; other site 401473002084 catalytic residues [active] 401473002085 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK03007 401473002086 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 401473002087 DNA primase; Validated; Region: dnaG; PRK05667 401473002088 CHC2 zinc finger; Region: zf-CHC2; pfam01807 401473002089 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 401473002090 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 401473002091 active site 401473002092 metal binding site [ion binding]; metal-binding site 401473002093 interdomain interaction site; other site 401473002094 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 401473002095 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 401473002096 transmembrane helices; other site 401473002097 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 401473002098 VanZ like family; Region: VanZ; pfam04892 401473002099 Protein of unknown function, DUF606; Region: DUF606; pfam04657 401473002100 Protein of unknown function, DUF606; Region: DUF606; pfam04657 401473002101 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 401473002102 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 401473002103 G1 box; other site 401473002104 putative GEF interaction site [polypeptide binding]; other site 401473002105 GTP/Mg2+ binding site [chemical binding]; other site 401473002106 Switch I region; other site 401473002107 G2 box; other site 401473002108 G3 box; other site 401473002109 Switch II region; other site 401473002110 G4 box; other site 401473002111 G5 box; other site 401473002112 Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787 401473002113 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cl02789 401473002114 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 401473002115 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 401473002116 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 401473002117 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 401473002118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002119 dimer interface [polypeptide binding]; other site 401473002120 conserved gate region; other site 401473002121 putative PBP binding loops; other site 401473002122 ABC-ATPase subunit interface; other site 401473002123 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002124 dimer interface [polypeptide binding]; other site 401473002125 conserved gate region; other site 401473002126 putative PBP binding loops; other site 401473002127 ABC-ATPase subunit interface; other site 401473002128 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 401473002129 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 401473002130 Walker A/P-loop; other site 401473002131 ATP binding site [chemical binding]; other site 401473002132 Q-loop/lid; other site 401473002133 ABC transporter signature motif; other site 401473002134 Walker B; other site 401473002135 D-loop; other site 401473002136 H-loop/switch region; other site 401473002137 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 401473002138 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401473002139 substrate binding pocket [chemical binding]; other site 401473002140 membrane-bound complex binding site; other site 401473002141 hinge residues; other site 401473002142 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 401473002143 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 401473002144 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 401473002145 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 401473002146 potential frameshift: common BLAST hit: gi|241196701|ref|YP_002970256.1| ABC transporter ATP-binding protein 401473002147 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 401473002148 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 401473002149 Walker A/P-loop; other site 401473002150 ATP binding site [chemical binding]; other site 401473002151 Q-loop/lid; other site 401473002152 ABC transporter signature motif; other site 401473002153 Walker B; other site 401473002154 D-loop; other site 401473002155 H-loop/switch region; other site 401473002156 NIL domain; Region: NIL; pfam09383 401473002157 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002158 dimer interface [polypeptide binding]; other site 401473002159 conserved gate region; other site 401473002160 putative PBP binding loops; other site 401473002161 ABC-ATPase subunit interface; other site 401473002162 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473002163 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473002164 homodimer interface [polypeptide binding]; other site 401473002165 catalytic residue [active] 401473002166 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 401473002167 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 401473002168 homodimer interface [polypeptide binding]; other site 401473002169 substrate-cofactor binding pocket; other site 401473002170 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473002171 catalytic residue [active] 401473002172 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 401473002173 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473002174 Walker B; other site 401473002175 D-loop; other site 401473002176 H-loop/switch region; other site 401473002177 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 401473002178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401473002179 substrate binding pocket [chemical binding]; other site 401473002180 membrane-bound complex binding site; other site 401473002181 hinge residues; other site 401473002182 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 401473002183 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002184 dimer interface [polypeptide binding]; other site 401473002185 conserved gate region; other site 401473002186 putative PBP binding loops; other site 401473002187 ABC-ATPase subunit interface; other site 401473002188 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 401473002189 active site 401473002190 NAD binding site [chemical binding]; other site 401473002191 metal binding site [ion binding]; metal-binding site 401473002192 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473002193 ABC transporter signature motif; other site 401473002194 Walker B; other site 401473002195 D-loop; other site 401473002196 H-loop/switch region; other site 401473002197 NIL domain; Region: NIL; pfam09383 401473002198 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002199 dimer interface [polypeptide binding]; other site 401473002200 conserved gate region; other site 401473002201 ABC-ATPase subunit interface; other site 401473002202 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 401473002203 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 401473002204 Protein of unknown function (DUF1684); Region: DUF1684; pfam07920 401473002205 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 401473002206 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 401473002207 putative active site [active] 401473002208 metal binding site [ion binding]; metal-binding site 401473002209 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 401473002210 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 401473002211 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473002212 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473002213 Walker A/P-loop; other site 401473002214 ATP binding site [chemical binding]; other site 401473002215 Q-loop/lid; other site 401473002216 ABC transporter signature motif; other site 401473002217 Walker B; other site 401473002218 D-loop; other site 401473002219 H-loop/switch region; other site 401473002220 S-layer domain [Cell envelope biogenesis, outer membrane]; Region: COG1361 401473002221 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473002222 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 401473002223 FtsX-like permease family; Region: FtsX; pfam02687 401473002224 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 401473002225 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 401473002226 TPP-binding site; other site 401473002227 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 401473002228 PYR/PP interface [polypeptide binding]; other site 401473002229 dimer interface [polypeptide binding]; other site 401473002230 TPP binding site [chemical binding]; other site 401473002231 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 401473002232 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 401473002233 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 401473002234 NAD(P) binding site [chemical binding]; other site 401473002235 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 401473002236 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 401473002237 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 401473002238 NAD binding site [chemical binding]; other site 401473002239 ATP-grasp domain; Region: ATP-grasp; pfam02222 401473002240 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 401473002241 metal binding site 2 [ion binding]; metal-binding site 401473002242 putative DNA binding helix; other site 401473002243 metal binding site 1 [ion binding]; metal-binding site 401473002244 dimer interface [polypeptide binding]; other site 401473002245 structural Zn2+ binding site [ion binding]; other site 401473002246 Sulfatase; Region: Sulfatase; pfam00884 401473002247 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 401473002248 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 401473002249 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 401473002250 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 401473002251 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 401473002252 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 401473002253 dimerization interface [polypeptide binding]; other site 401473002254 putative ATP binding site [chemical binding]; other site 401473002255 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 401473002256 active site 401473002257 tetramer interface [polypeptide binding]; other site 401473002258 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401473002259 active site 401473002260 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 401473002261 Y-family of DNA polymerases; Region: PolY; cl12025 401473002262 active site 401473002263 DNA binding site [nucleotide binding] 401473002264 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 401473002265 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 401473002266 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 401473002267 dimerization interface [polypeptide binding]; other site 401473002268 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 401473002269 dimerization interface [polypeptide binding]; other site 401473002270 ATP binding site [chemical binding]; other site 401473002271 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 401473002272 dimerization interface [polypeptide binding]; other site 401473002273 ATP binding site [chemical binding]; other site 401473002274 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 401473002275 putative active site [active] 401473002276 catalytic triad [active] 401473002277 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 401473002278 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 401473002279 active site 401473002280 substrate binding site [chemical binding]; other site 401473002281 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 401473002282 ATP-grasp domain; Region: ATP-grasp; pfam02222 401473002283 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401473002284 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401473002285 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 401473002286 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 401473002287 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401473002288 catalytic residue [active] 401473002289 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 401473002290 Sodium Bile acid symporter family; Region: SBF; pfam01758 401473002291 30S ribosomal protein S12; Validated; Region: rpsL; PRK05163 401473002292 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 401473002293 30S ribosomal protein S7; Validated; Region: PRK05302 401473002294 elongation factor G; Reviewed; Region: PRK00007 401473002295 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 401473002296 G1 box; other site 401473002297 putative GEF interaction site [polypeptide binding]; other site 401473002298 GTP/Mg2+ binding site [chemical binding]; other site 401473002299 Switch I region; other site 401473002300 G2 box; other site 401473002301 G3 box; other site 401473002302 Switch II region; other site 401473002303 G4 box; other site 401473002304 G5 box; other site 401473002305 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 401473002306 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 401473002307 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 401473002308 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 401473002309 G4 box; other site 401473002310 G5 box; other site 401473002311 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 401473002312 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 401473002313 Antibiotic Binding Site [chemical binding]; other site 401473002314 elongation factor P; Validated; Region: PRK00529 401473002315 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 401473002316 RNA binding site [nucleotide binding]; other site 401473002317 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 401473002318 RNA binding site [nucleotide binding]; other site 401473002319 transcription antitermination factor NusB; Region: nusB; TIGR01951 401473002320 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 401473002321 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 401473002322 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 401473002323 catalytic site [active] 401473002324 subunit interface [polypeptide binding]; other site 401473002325 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 401473002326 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401473002327 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401473002328 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 401473002329 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 401473002330 ATP-grasp domain; Region: ATP-grasp_4; cl17255 401473002331 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 401473002332 IMP binding site; other site 401473002333 dimer interface [polypeptide binding]; other site 401473002334 interdomain contacts; other site 401473002335 partial ornithine binding site; other site 401473002336 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 401473002337 active site 401473002338 dimer interface [polypeptide binding]; other site 401473002339 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 401473002340 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 401473002341 catalytic site [active] 401473002342 G-X2-G-X-G-K; other site 401473002343 Similar to ISBlo3 perfect TIRs 17bp 401473002344 Helix-turn-helix domain; Region: HTH_28; pfam13518 401473002345 Transposase; Region: HTH_Tnp_1; cl17663 401473002346 Integrase core domain; Region: rve; pfam00665 401473002347 DDE domain; Region: DDE_Tnp_IS240; pfam13610 401473002348 Integrase core domain; Region: rve_2; pfam13333 401473002349 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 401473002350 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 401473002351 S-adenosylmethionine synthetase; Validated; Region: PRK05250 401473002352 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 401473002353 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 401473002354 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 401473002355 primosome assembly protein PriA; Provisional; Region: PRK14873 401473002356 Subunit B of Class III Extradiol ring-cleavage dioxygenases; Region: Extradiol_Dioxygenase_3B_like; cl00599 401473002357 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 401473002358 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473002359 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 401473002360 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 401473002361 putative active site [active] 401473002362 substrate binding site [chemical binding]; other site 401473002363 putative cosubstrate binding site; other site 401473002364 catalytic site [active] 401473002365 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 401473002366 substrate binding site [chemical binding]; other site 401473002367 phosphoserine phosphatase SerB; Region: serB; TIGR00338 401473002368 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473002369 motif II; other site 401473002370 proteasome ATPase; Region: pup_AAA; TIGR03689 401473002371 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473002372 Walker A motif; other site 401473002373 ATP binding site [chemical binding]; other site 401473002374 Walker B motif; other site 401473002375 arginine finger; other site 401473002376 Pup-ligase protein; Region: Pup_ligase; cl15463 401473002377 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 401473002378 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 401473002379 active site 401473002380 ubiquitin-like protein Pup; Region: pupylate_cterm; TIGR03687 401473002381 Pup-ligase protein; Region: Pup_ligase; cl15463 401473002382 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 401473002383 IHF dimer interface [polypeptide binding]; other site 401473002384 IHF - DNA interface [nucleotide binding]; other site 401473002385 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 401473002386 adenylosuccinate lyase; Provisional; Region: PRK09285 401473002387 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 401473002388 tetramer interface [polypeptide binding]; other site 401473002389 active site 401473002390 PGAP1-like protein; Region: PGAP1; pfam07819 401473002391 Proteins of 100 residues with WXG; Region: WXG100; cl02005 401473002392 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 401473002393 metal ion-dependent adhesion site (MIDAS); other site 401473002394 von Willebrand factor type A domain; Region: VWA_2; pfam13519 401473002395 Protein of unknown function DUF58; Region: DUF58; pfam01882 401473002396 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 401473002397 MoxR-like ATPases [General function prediction only]; Region: COG0714 401473002398 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 401473002399 ligand binding site [chemical binding]; other site 401473002400 active site 401473002401 UGI interface [polypeptide binding]; other site 401473002402 catalytic site [active] 401473002403 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 401473002404 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 401473002405 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 401473002406 ring oligomerisation interface [polypeptide binding]; other site 401473002407 ATP/Mg binding site [chemical binding]; other site 401473002408 stacking interactions; other site 401473002409 hinge regions; other site 401473002410 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 401473002411 Repair protein; Region: Repair_PSII; cl01535 401473002412 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 401473002413 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473002414 active site 401473002415 phosphorylation site [posttranslational modification] 401473002416 intermolecular recognition site; other site 401473002417 dimerization interface [polypeptide binding]; other site 401473002418 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401473002419 DNA binding site [nucleotide binding] 401473002420 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 401473002421 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 401473002422 dimerization interface [polypeptide binding]; other site 401473002423 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 401473002424 dimer interface [polypeptide binding]; other site 401473002425 phosphorylation site [posttranslational modification] 401473002426 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473002427 ATP binding site [chemical binding]; other site 401473002428 Mg2+ binding site [ion binding]; other site 401473002429 G-X-G motif; other site 401473002430 Protein of unknown function (DUF3027); Region: DUF3027; pfam11228 401473002431 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 401473002432 Ligand Binding Site [chemical binding]; other site 401473002433 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 401473002434 Ligand Binding Site [chemical binding]; other site 401473002435 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 401473002436 Clp amino terminal domain; Region: Clp_N; pfam02861 401473002437 Clp amino terminal domain; Region: Clp_N; pfam02861 401473002438 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473002439 Walker A motif; other site 401473002440 ATP binding site [chemical binding]; other site 401473002441 Walker B motif; other site 401473002442 arginine finger; other site 401473002443 UvrB/uvrC motif; Region: UVR; pfam02151 401473002444 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473002445 Walker A motif; other site 401473002446 ATP binding site [chemical binding]; other site 401473002447 Walker B motif; other site 401473002448 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 401473002449 Domain of Unknown Function (DUF349); Region: DUF349; pfam03993 401473002450 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 401473002451 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 401473002452 dimer interface [polypeptide binding]; other site 401473002453 motif 1; other site 401473002454 active site 401473002455 motif 2; other site 401473002456 motif 3; other site 401473002457 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 401473002458 anticodon binding site; other site 401473002459 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 401473002460 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 401473002461 dimer interface [polypeptide binding]; other site 401473002462 anticodon binding site; other site 401473002463 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 401473002464 motif 1; other site 401473002465 dimer interface [polypeptide binding]; other site 401473002466 active site 401473002467 motif 2; other site 401473002468 GAD domain; Region: GAD; pfam02938 401473002469 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 401473002470 active site 401473002471 motif 3; other site 401473002472 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 401473002473 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401473002474 substrate binding pocket [chemical binding]; other site 401473002475 membrane-bound complex binding site; other site 401473002476 hinge residues; other site 401473002477 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 401473002478 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002479 dimer interface [polypeptide binding]; other site 401473002480 conserved gate region; other site 401473002481 putative PBP binding loops; other site 401473002482 ABC-ATPase subunit interface; other site 401473002483 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 401473002484 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 401473002485 Walker A/P-loop; other site 401473002486 ATP binding site [chemical binding]; other site 401473002487 Q-loop/lid; other site 401473002488 ABC transporter signature motif; other site 401473002489 Walker B; other site 401473002490 D-loop; other site 401473002491 H-loop/switch region; other site 401473002492 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 401473002493 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 401473002494 Walker A/P-loop; other site 401473002495 ATP binding site [chemical binding]; other site 401473002496 Q-loop/lid; other site 401473002497 ABC transporter signature motif; other site 401473002498 Walker B; other site 401473002499 D-loop; other site 401473002500 H-loop/switch region; other site 401473002501 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401473002502 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 401473002503 substrate binding pocket [chemical binding]; other site 401473002504 membrane-bound complex binding site; other site 401473002505 hinge residues; other site 401473002506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002507 dimer interface [polypeptide binding]; other site 401473002508 conserved gate region; other site 401473002509 ABC-ATPase subunit interface; other site 401473002510 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 401473002511 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002512 dimer interface [polypeptide binding]; other site 401473002513 conserved gate region; other site 401473002514 putative PBP binding loops; other site 401473002515 ABC-ATPase subunit interface; other site 401473002516 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 401473002517 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473002518 ATP binding site [chemical binding]; other site 401473002519 putative Mg++ binding site [ion binding]; other site 401473002520 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473002521 nucleotide binding region [chemical binding]; other site 401473002522 ATP-binding site [chemical binding]; other site 401473002523 Domain of unknown function (DUF3516); Region: DUF3516; pfam12029 401473002524 recombination factor protein RarA; Reviewed; Region: PRK13342 401473002525 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473002526 Walker A motif; other site 401473002527 ATP binding site [chemical binding]; other site 401473002528 Walker B motif; other site 401473002529 arginine finger; other site 401473002530 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 401473002531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473002532 putative substrate translocation pore; other site 401473002533 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473002534 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 401473002535 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 401473002536 Clp protease; Region: CLP_protease; pfam00574 401473002537 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 401473002538 oligomer interface [polypeptide binding]; other site 401473002539 active site residues [active] 401473002540 ATP-dependent Clp protease proteolytic subunit; Reviewed; Region: PRK12553 401473002541 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 401473002542 oligomer interface [polypeptide binding]; other site 401473002543 active site residues [active] 401473002544 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 401473002545 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 401473002546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473002547 Walker A motif; other site 401473002548 ATP binding site [chemical binding]; other site 401473002549 Walker B motif; other site 401473002550 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 401473002551 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 401473002552 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 401473002553 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 401473002554 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 401473002555 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 401473002556 L-aspartate oxidase; Provisional; Region: PRK06175 401473002557 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08205 401473002558 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 401473002559 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 401473002560 DNA protecting protein DprA; Region: dprA; TIGR00732 401473002561 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 401473002562 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 401473002563 Uncharacterized protein conserved in archaea (DUF2124); Region: DUF2124; cl01695 401473002564 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473002565 Walker A motif; other site 401473002566 ATP binding site [chemical binding]; other site 401473002567 Walker B motif; other site 401473002568 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 401473002569 hypothetical protein; Provisional; Region: PRK14681 401473002570 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 401473002571 dimer interface [polypeptide binding]; other site 401473002572 pyridoxal binding site [chemical binding]; other site 401473002573 ATP binding site [chemical binding]; other site 401473002574 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 401473002575 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 401473002576 homodimer interface [polypeptide binding]; other site 401473002577 substrate-cofactor binding pocket; other site 401473002578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473002579 catalytic residue [active] 401473002580 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 401473002581 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 401473002582 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 401473002583 Walker A/P-loop; other site 401473002584 ATP binding site [chemical binding]; other site 401473002585 Q-loop/lid; other site 401473002586 ABC transporter signature motif; other site 401473002587 Walker B; other site 401473002588 D-loop; other site 401473002589 H-loop/switch region; other site 401473002590 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 401473002591 Walker A/P-loop; other site 401473002592 ATP binding site [chemical binding]; other site 401473002593 Q-loop/lid; other site 401473002594 ABC transporter signature motif; other site 401473002595 Walker B; other site 401473002596 D-loop; other site 401473002597 H-loop/switch region; other site 401473002598 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 401473002599 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 401473002600 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 401473002601 AsnC family; Region: AsnC_trans_reg; pfam01037 401473002602 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 401473002603 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 401473002604 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473002605 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473002606 Walker A/P-loop; other site 401473002607 ATP binding site [chemical binding]; other site 401473002608 Q-loop/lid; other site 401473002609 ABC transporter signature motif; other site 401473002610 Walker B; other site 401473002611 D-loop; other site 401473002612 H-loop/switch region; other site 401473002613 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 401473002614 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473002615 FtsX-like permease family; Region: FtsX; pfam02687 401473002616 FtsX-like permease family; Region: FtsX; pfam02687 401473002617 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 401473002618 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473002619 active site 401473002620 phosphorylation site [posttranslational modification] 401473002621 intermolecular recognition site; other site 401473002622 dimerization interface [polypeptide binding]; other site 401473002623 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 401473002624 DNA binding residues [nucleotide binding] 401473002625 dimerization interface [polypeptide binding]; other site 401473002626 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 401473002627 Histidine kinase; Region: HisKA_3; pfam07730 401473002628 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473002629 ATP binding site [chemical binding]; other site 401473002630 Mg2+ binding site [ion binding]; other site 401473002631 G-X-G motif; other site 401473002632 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 401473002633 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 401473002634 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 401473002635 GTP-binding protein YchF; Reviewed; Region: PRK09601 401473002636 YchF GTPase; Region: YchF; cd01900 401473002637 Switch I region; other site 401473002638 G2 box; other site 401473002639 Switch II region; other site 401473002640 G3 box; other site 401473002641 GTP/Mg2+ binding site [chemical binding]; other site 401473002642 G4 box; other site 401473002643 G5 box; other site 401473002644 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 401473002645 Predicted transcriptional regulators [Transcription]; Region: COG1725 401473002646 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 401473002647 DNA-binding site [nucleotide binding]; DNA binding site 401473002648 Predicted membrane protein [General function prediction only]; Region: COG4194 401473002649 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 401473002650 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 401473002651 EamA-like transporter family; Region: EamA; pfam00892 401473002652 EamA-like transporter family; Region: EamA; pfam00892 401473002653 Predicted membrane protein [Function unknown]; Region: COG2855 401473002654 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 401473002655 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401473002656 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401473002657 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 401473002658 dimerization interface [polypeptide binding]; other site 401473002659 Domain of unknown function (DUF362); Region: DUF362; pfam04015 401473002660 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 401473002661 AAA domain; Region: AAA_18; pfam13238 401473002662 active site 401473002663 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 401473002664 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401473002665 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 401473002666 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401473002667 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473002668 catalytic core [active] 401473002669 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 401473002670 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 401473002671 classical (c) SDRs; Region: SDR_c; cd05233 401473002672 NAD(P) binding site [chemical binding]; other site 401473002673 active site 401473002674 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 401473002675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 401473002676 ATP binding site [chemical binding]; other site 401473002677 putative Mg++ binding site [ion binding]; other site 401473002678 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473002679 nucleotide binding region [chemical binding]; other site 401473002680 ATP-binding site [chemical binding]; other site 401473002681 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390 401473002682 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473002683 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 401473002684 Walker A/P-loop; other site 401473002685 ATP binding site [chemical binding]; other site 401473002686 Q-loop/lid; other site 401473002687 ABC transporter signature motif; other site 401473002688 Walker B; other site 401473002689 D-loop; other site 401473002690 H-loop/switch region; other site 401473002691 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 401473002692 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 401473002693 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 401473002694 conserved cys residue [active] 401473002695 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 401473002696 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 401473002697 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 401473002698 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 401473002699 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 401473002700 putative active site [active] 401473002701 glucose-6-phosphate dehydrogenase assembly protein OpcA; Region: OpcA; TIGR00534 401473002702 Glucose-6-phosphate dehydrogenase subunit; Region: OpcA_G6PD_assem; pfam10128 401473002703 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 401473002704 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 401473002705 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 401473002706 Pyrimidine reductase, riboflavin biosynthesis [Coenzyme metabolism]; Region: RibD; COG1985 401473002707 RibD C-terminal domain; Region: RibD_C; cl17279 401473002708 classical (c) SDRs; Region: SDR_c; cd05233 401473002709 NAD(P) binding site [chemical binding]; other site 401473002710 active site 401473002711 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 401473002712 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 401473002713 DNA binding site [nucleotide binding] 401473002714 active site 401473002715 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 401473002716 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 401473002717 NADH(P)-binding; Region: NAD_binding_10; pfam13460 401473002718 NAD(P) binding site [chemical binding]; other site 401473002719 putative active site [active] 401473002720 Transcriptional regulator [Transcription]; Region: LysR; COG0583 401473002721 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 401473002722 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 401473002723 dimerization interface [polypeptide binding]; other site 401473002724 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 401473002725 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 401473002726 active site 401473002727 substrate binding site [chemical binding]; other site 401473002728 trimer interface [polypeptide binding]; other site 401473002729 CoA binding site [chemical binding]; other site 401473002730 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 401473002731 AzlC protein; Region: AzlC; cl00570 401473002732 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 401473002733 carbon starvation protein A; Provisional; Region: PRK15015 401473002734 Carbon starvation protein CstA; Region: CstA; pfam02554 401473002735 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 401473002736 Protein of unknown function (DUF466); Region: DUF466; cl01082 401473002737 Uncharacterized conserved protein [Function unknown]; Region: COG1615 401473002738 Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699 401473002739 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 401473002740 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401473002741 Coenzyme A binding pocket [chemical binding]; other site 401473002742 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 401473002743 putative active site [active] 401473002744 catalytic residue [active] 401473002745 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 401473002746 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 401473002747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473002748 ATP binding site [chemical binding]; other site 401473002749 putative Mg++ binding site [ion binding]; other site 401473002750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473002751 nucleotide binding region [chemical binding]; other site 401473002752 ATP-binding site [chemical binding]; other site 401473002753 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 401473002754 enolase; Provisional; Region: eno; PRK00077 401473002755 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 401473002756 dimer interface [polypeptide binding]; other site 401473002757 metal binding site [ion binding]; metal-binding site 401473002758 substrate binding pocket [chemical binding]; other site 401473002759 Septum formation initiator; Region: DivIC; pfam04977 401473002760 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 401473002761 Protein of unknown function (DUF501); Region: DUF501; pfam04417 401473002762 exopolyphosphatase; Region: exo_poly_only; TIGR03706 401473002763 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 401473002764 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 401473002765 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 401473002766 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 401473002767 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 401473002768 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 401473002769 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 401473002770 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 401473002771 ATP synthase archaeal, H subunit; Region: AhaH; TIGR02926 401473002772 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 401473002773 Haemolysin-III related; Region: HlyIII; pfam03006 401473002774 Signal transduction histidine kinase; Region: H_kinase_N; pfam12282 401473002775 PAS fold; Region: PAS_4; pfam08448 401473002776 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 401473002777 Histidine kinase; Region: HisKA_2; pfam07568 401473002778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473002779 ATP binding site [chemical binding]; other site 401473002780 Mg2+ binding site [ion binding]; other site 401473002781 G-X-G motif; other site 401473002782 Transcription factor WhiB; Region: Whib; pfam02467 401473002783 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 401473002784 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 401473002785 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 401473002786 Transcription factor WhiB; Region: Whib; pfam02467 401473002787 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 401473002788 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 401473002789 Minimal MMP-like domain found in a group of hypothetical proteins from alphaproteobacteria and actinobacteria; Region: MMP_TTHA0227_like_1; cd12954 401473002790 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 401473002791 Eukaryotic phosphomannomutase; Region: PMM; cl17107 401473002792 comF family protein; Region: comF; TIGR00201 401473002793 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401473002794 active site 401473002795 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 401473002796 GtrA-like protein; Region: GtrA; pfam04138 401473002797 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 401473002798 dimerization interface [polypeptide binding]; other site 401473002799 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 401473002800 dimer interface [polypeptide binding]; other site 401473002801 phosphorylation site [posttranslational modification] 401473002802 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473002803 ATP binding site [chemical binding]; other site 401473002804 Mg2+ binding site [ion binding]; other site 401473002805 G-X-G motif; other site 401473002806 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 401473002807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473002808 active site 401473002809 phosphorylation site [posttranslational modification] 401473002810 intermolecular recognition site; other site 401473002811 dimerization interface [polypeptide binding]; other site 401473002812 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401473002813 DNA binding site [nucleotide binding] 401473002814 glycogen branching enzyme; Provisional; Region: PRK05402 401473002815 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 401473002816 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 401473002817 active site 401473002818 catalytic site [active] 401473002819 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 401473002820 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; cl00588 401473002821 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 401473002822 homotrimer interaction site [polypeptide binding]; other site 401473002823 zinc binding site [ion binding]; other site 401473002824 CDP-binding sites; other site 401473002825 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 401473002826 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 401473002827 ABC-ATPase subunit interface; other site 401473002828 dimer interface [polypeptide binding]; other site 401473002829 putative PBP binding regions; other site 401473002830 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 401473002831 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 401473002832 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 401473002833 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 401473002834 intersubunit interface [polypeptide binding]; other site 401473002835 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14193 401473002836 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 401473002837 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 401473002838 homodimer interface [polypeptide binding]; other site 401473002839 NADP binding site [chemical binding]; other site 401473002840 substrate binding site [chemical binding]; other site 401473002841 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK07899 401473002842 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 401473002843 RNA binding site [nucleotide binding]; other site 401473002844 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 401473002845 RNA binding site [nucleotide binding]; other site 401473002846 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 401473002847 RNA binding site [nucleotide binding]; other site 401473002848 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 401473002849 RNA binding site [nucleotide binding]; other site 401473002850 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 401473002851 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 401473002852 CoA-binding site [chemical binding]; other site 401473002853 ATP-binding [chemical binding]; other site 401473002854 excinuclease ABC subunit B; Provisional; Region: PRK05298 401473002855 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473002856 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473002857 nucleotide binding region [chemical binding]; other site 401473002858 ATP-binding site [chemical binding]; other site 401473002859 Ultra-violet resistance protein B; Region: UvrB; pfam12344 401473002860 UvrB/uvrC motif; Region: UVR; pfam02151 401473002861 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 401473002862 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 401473002863 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 401473002864 domain interfaces; other site 401473002865 active site 401473002866 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 401473002867 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 401473002868 dimer interface [polypeptide binding]; other site 401473002869 ADP-ribose binding site [chemical binding]; other site 401473002870 active site 401473002871 nudix motif; other site 401473002872 metal binding site [ion binding]; metal-binding site 401473002873 Helix-turn-helix domain; Region: HTH_38; pfam13936 401473002874 Protein of unknown function (DUF2637); Region: DUF2637; pfam10935 401473002875 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 401473002876 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401473002877 putative DNA binding site [nucleotide binding]; other site 401473002878 putative Zn2+ binding site [ion binding]; other site 401473002879 Fic family protein [Function unknown]; Region: COG3177 401473002880 Fic/DOC family; Region: Fic; pfam02661 401473002881 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 401473002882 Uncharacterized conserved protein [Function unknown]; Region: COG4933 401473002883 Protein of unknown function (DUF2786); Region: DUF2786; pfam10979 401473002884 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 401473002885 active site 401473002886 catalytic site [active] 401473002887 substrate binding site [chemical binding]; other site 401473002888 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 401473002889 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 401473002890 dimer interface [polypeptide binding]; other site 401473002891 ssDNA binding site [nucleotide binding]; other site 401473002892 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401473002893 TrwC relaxase; Region: TrwC; pfam08751 401473002894 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 401473002895 AAA domain; Region: AAA_30; pfam13604 401473002896 AAA domain; Region: AAA_22; pfam13401 401473002897 Helix-turn-helix XRE-family like proteins; Region: HTH_XRE; smart00530 401473002898 Plasmid encoded RepA protein; Region: RepA_C; pfam04796 401473002899 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 401473002900 beta-galactosidase; Region: BGL; TIGR03356 401473002901 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473002902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002903 dimer interface [polypeptide binding]; other site 401473002904 conserved gate region; other site 401473002905 putative PBP binding loops; other site 401473002906 ABC-ATPase subunit interface; other site 401473002907 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 401473002908 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473002909 dimer interface [polypeptide binding]; other site 401473002910 conserved gate region; other site 401473002911 putative PBP binding loops; other site 401473002912 ABC-ATPase subunit interface; other site 401473002913 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473002914 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473002915 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 401473002916 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473002917 dimerization interface [polypeptide binding]; other site 401473002918 ligand binding site [chemical binding]; other site 401473002919 Type IV secretory pathway, VirD4 components [Intracellular trafficking and secretion]; Region: VirD4; COG3505 401473002920 TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696 401473002921 AAA-like domain; Region: AAA_10; pfam12846 401473002922 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 401473002923 HipA-like C-terminal domain; Region: HipA_C; pfam07804 401473002924 hypothetical protein; Provisional; Region: PRK04140 401473002925 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 401473002926 Surface antigen [General function prediction only]; Region: COG3942 401473002927 CHAP domain; Region: CHAP; pfam05257 401473002928 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 401473002929 N-acetyl-D-glucosamine binding site [chemical binding]; other site 401473002930 catalytic residue [active] 401473002931 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 401473002932 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 401473002933 active site 401473002934 DNA binding site [nucleotide binding] 401473002935 Int/Topo IB signature motif; other site 401473002936 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 401473002937 Predicted membrane protein [Function unknown]; Region: COG2323 401473002938 CAAX protease self-immunity; Region: Abi; pfam02517 401473002939 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 401473002940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473002941 active site 401473002942 phosphorylation site [posttranslational modification] 401473002943 intermolecular recognition site; other site 401473002944 dimerization interface [polypeptide binding]; other site 401473002945 ANTAR domain; Region: ANTAR; pfam03861 401473002946 DNA polymerase I; Provisional; Region: PRK05755 401473002947 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 401473002948 active site 401473002949 metal binding site 1 [ion binding]; metal-binding site 401473002950 putative 5' ssDNA interaction site; other site 401473002951 metal binding site 3; metal-binding site 401473002952 metal binding site 2 [ion binding]; metal-binding site 401473002953 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 401473002954 putative DNA binding site [nucleotide binding]; other site 401473002955 putative metal binding site [ion binding]; other site 401473002956 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 401473002957 active site 401473002958 substrate binding site [chemical binding]; other site 401473002959 catalytic site [active] 401473002960 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 401473002961 active site 401473002962 DNA binding site [nucleotide binding] 401473002963 catalytic site [active] 401473002964 Uncharacterized conserved protein [Function unknown]; Region: COG0327 401473002965 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 401473002966 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 401473002967 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 401473002968 dimer interface [polypeptide binding]; other site 401473002969 ADP-ribose binding site [chemical binding]; other site 401473002970 active site 401473002971 nudix motif; other site 401473002972 metal binding site [ion binding]; metal-binding site 401473002973 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 401473002974 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 401473002975 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 401473002976 active site 401473002977 catalytic site [active] 401473002978 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 401473002979 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 401473002980 hinge; other site 401473002981 active site 401473002982 Uncharacterized conserved protein [Function unknown]; Region: COG4127 401473002983 Restriction endonuclease; Region: Mrr_cat; pfam04471 401473002984 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 401473002985 Double zinc ribbon; Region: DZR; pfam12773 401473002986 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 401473002987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473002988 active site 401473002989 phosphorylation site [posttranslational modification] 401473002990 intermolecular recognition site; other site 401473002991 dimerization interface [polypeptide binding]; other site 401473002992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 401473002993 DNA binding residues [nucleotide binding] 401473002994 dimerization interface [polypeptide binding]; other site 401473002995 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 401473002996 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 401473002997 ATP binding site [chemical binding]; other site 401473002998 Mg2+ binding site [ion binding]; other site 401473002999 G-X-G motif; other site 401473003000 GMP synthase; Reviewed; Region: guaA; PRK00074 401473003001 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 401473003002 AMP/PPi binding site [chemical binding]; other site 401473003003 candidate oxyanion hole; other site 401473003004 catalytic triad [active] 401473003005 potential glutamine specificity residues [chemical binding]; other site 401473003006 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 401473003007 ATP Binding subdomain [chemical binding]; other site 401473003008 Ligand Binding sites [chemical binding]; other site 401473003009 Dimerization subdomain; other site 401473003010 putative phosphoketolase; Provisional; Region: PRK05261 401473003011 XFP N-terminal domain; Region: XFP_N; pfam09364 401473003012 XFP C-terminal domain; Region: XFP_C; pfam09363 401473003013 AAA domain; Region: AAA_26; pfam13500 401473003014 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 401473003015 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 401473003016 propionate/acetate kinase; Provisional; Region: PRK12379 401473003017 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 401473003018 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 401473003019 catalytic triad [active] 401473003020 catalytic triad [active] 401473003021 oxyanion hole [active] 401473003022 xanthine permease; Region: pbuX; TIGR03173 401473003023 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401473003024 active site 401473003025 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 401473003026 Part of AAA domain; Region: AAA_19; pfam13245 401473003027 Family description; Region: UvrD_C_2; pfam13538 401473003028 Domain of unknown function (DUF4418); Region: DUF4418; pfam14387 401473003029 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473003030 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 401473003031 FtsX-like permease family; Region: FtsX; pfam02687 401473003032 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473003033 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473003034 Walker A/P-loop; other site 401473003035 ATP binding site [chemical binding]; other site 401473003036 Q-loop/lid; other site 401473003037 ABC transporter signature motif; other site 401473003038 Walker B; other site 401473003039 D-loop; other site 401473003040 H-loop/switch region; other site 401473003041 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 401473003042 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 401473003043 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401473003044 RNA binding surface [nucleotide binding]; other site 401473003045 Membrane protein of unknown function; Region: DUF360; pfam04020 401473003046 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473003047 catalytic core [active] 401473003048 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 401473003049 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 401473003050 motif 1; other site 401473003051 active site 401473003052 motif 2; other site 401473003053 motif 3; other site 401473003054 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 401473003055 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 401473003056 YceG-like family; Region: YceG; pfam02618 401473003057 proteins similar to Escherichia coli yceG; Region: yceG_like; cl17666 401473003058 dimerization interface [polypeptide binding]; other site 401473003059 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 401473003060 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 401473003061 Tetramer interface [polypeptide binding]; other site 401473003062 active site 401473003063 FMN-binding site [chemical binding]; other site 401473003064 bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK14021 401473003065 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 401473003066 ADP binding site [chemical binding]; other site 401473003067 magnesium binding site [ion binding]; other site 401473003068 putative shikimate binding site; other site 401473003069 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 401473003070 active site 401473003071 dimer interface [polypeptide binding]; other site 401473003072 metal binding site [ion binding]; metal-binding site 401473003073 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 401473003074 Dehydroquinase class II; Region: DHquinase_II; pfam01220 401473003075 trimer interface [polypeptide binding]; other site 401473003076 active site 401473003077 dimer interface [polypeptide binding]; other site 401473003078 Alpha amylase catalytic domain found in bacterial and eukaryotic Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_euk_AmyA; cd11317 401473003079 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 401473003080 active site 401473003081 Ca binding site [ion binding]; other site 401473003082 catalytic site [active] 401473003083 Aamy_C domain; Region: Aamy_C; smart00632 401473003084 Carbohydrate binding domain (family 25); Region: CBM_25; cl04060 401473003085 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 401473003086 carbohydrate binding site [chemical binding]; other site 401473003087 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 401473003088 carbohydrate binding site [chemical binding]; other site 401473003089 pullulanase, type I; Region: pulA_typeI; TIGR02104 401473003090 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 401473003091 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 401473003092 Ca binding site [ion binding]; other site 401473003093 active site 401473003094 catalytic site [active] 401473003095 CTP synthetase; Validated; Region: pyrG; PRK05380 401473003096 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 401473003097 Catalytic site [active] 401473003098 active site 401473003099 UTP binding site [chemical binding]; other site 401473003100 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 401473003101 active site 401473003102 putative oxyanion hole; other site 401473003103 catalytic triad [active] 401473003104 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 401473003105 FeS assembly protein SufB; Region: sufB; TIGR01980 401473003106 FeS assembly protein SufD; Region: sufD; TIGR01981 401473003107 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 401473003108 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 401473003109 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 401473003110 Walker A/P-loop; other site 401473003111 ATP binding site [chemical binding]; other site 401473003112 Q-loop/lid; other site 401473003113 ABC transporter signature motif; other site 401473003114 Walker B; other site 401473003115 D-loop; other site 401473003116 H-loop/switch region; other site 401473003117 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 401473003118 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 401473003119 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 401473003120 catalytic residue [active] 401473003121 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 401473003122 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 401473003123 trimerization site [polypeptide binding]; other site 401473003124 active site 401473003125 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 401473003126 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844 401473003127 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 401473003128 ligand binding site; other site 401473003129 oligomer interface; other site 401473003130 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 401473003131 dimer interface [polypeptide binding]; other site 401473003132 N-terminal domain interface [polypeptide binding]; other site 401473003133 sulfate 1 binding site; other site 401473003134 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 401473003135 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 401473003136 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 401473003137 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 401473003138 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 401473003139 nucleotide binding site/active site [active] 401473003140 HIT family signature motif; other site 401473003141 catalytic residue [active] 401473003142 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 401473003143 PhoH-like protein; Region: PhoH; pfam02562 401473003144 metal-binding heat shock protein; Provisional; Region: PRK00016 401473003145 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 401473003146 Transporter associated domain; Region: CorC_HlyC; smart01091 401473003147 GTPase Era; Reviewed; Region: era; PRK00089 401473003148 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 401473003149 G1 box; other site 401473003150 GTP/Mg2+ binding site [chemical binding]; other site 401473003151 Switch I region; other site 401473003152 G2 box; other site 401473003153 Switch II region; other site 401473003154 G3 box; other site 401473003155 G4 box; other site 401473003156 G5 box; other site 401473003157 KH domain; Region: KH_2; pfam07650 401473003158 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 401473003159 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 401473003160 acyl-activating enzyme (AAE) consensus motif; other site 401473003161 putative AMP binding site [chemical binding]; other site 401473003162 putative active site [active] 401473003163 putative CoA binding site [chemical binding]; other site 401473003164 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 401473003165 NAD/NADP transhydrogenase alpha subunit [Energy production and conversion]; Region: PntA; COG3288 401473003166 ligand binding site [chemical binding]; other site 401473003167 homodimer interface [polypeptide binding]; other site 401473003168 NAD(P) binding site [chemical binding]; other site 401473003169 trimer interface B [polypeptide binding]; other site 401473003170 trimer interface A [polypeptide binding]; other site 401473003171 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 401473003172 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 401473003173 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; COG1282 401473003174 H+ Antiporter protein; Region: 2A0121; TIGR00900 401473003175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473003176 putative substrate translocation pore; other site 401473003177 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473003178 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473003179 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 401473003180 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 401473003181 XylS is a glycosyl hydrolase family 31 (GH31) alpha-xylosidase found in prokaryotes, eukaryotes, and archaea, that catalyzes the release of alpha-xylose from the non-reducing terminal side of the alpha-xyloside substrate. XylS has been characterized in...; Region: GH31_xylosidase_XylS; cd06591 401473003182 putative active site [active] 401473003183 putative catalytic site [active] 401473003184 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473003185 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473003186 DNA binding site [nucleotide binding] 401473003187 domain linker motif; other site 401473003188 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473003189 dimerization interface [polypeptide binding]; other site 401473003190 ligand binding site [chemical binding]; other site 401473003191 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 401473003192 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 401473003193 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401473003194 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 401473003195 active site 401473003196 catalytic tetrad [active] 401473003197 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 401473003198 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473003199 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473003200 Walker A/P-loop; other site 401473003201 ATP binding site [chemical binding]; other site 401473003202 Q-loop/lid; other site 401473003203 ABC transporter signature motif; other site 401473003204 Walker B; other site 401473003205 D-loop; other site 401473003206 H-loop/switch region; other site 401473003207 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 401473003208 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473003209 FtsX-like permease family; Region: FtsX; pfam02687 401473003210 Predicted transcriptional regulators [Transcription]; Region: COG1695 401473003211 Transcriptional regulator PadR-like family; Region: PadR; cl17335 401473003212 CrcB-like protein; Region: CRCB; pfam02537 401473003213 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 401473003214 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 401473003215 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 401473003216 acetylornithine aminotransferase; Provisional; Region: PRK02627 401473003217 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 401473003218 inhibitor-cofactor binding pocket; inhibition site 401473003219 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473003220 catalytic residue [active] 401473003221 Cytidylate kinase-like family; Region: Cytidylate_kin2; pfam13189 401473003222 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401473003223 Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH1; cd08185 401473003224 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 401473003225 putative active site [active] 401473003226 metal binding site [ion binding]; metal-binding site 401473003227 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 401473003228 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401473003229 Coenzyme A binding pocket [chemical binding]; other site 401473003230 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 401473003231 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 401473003232 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 401473003233 5S rRNA interface [nucleotide binding]; other site 401473003234 CTC domain interface [polypeptide binding]; other site 401473003235 L16 interface [polypeptide binding]; other site 401473003236 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 401473003237 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 401473003238 homodimer interface [polypeptide binding]; other site 401473003239 substrate-cofactor binding pocket; other site 401473003240 catalytic residue [active] 401473003241 UPF0126 domain; Region: UPF0126; pfam03458 401473003242 Predicted membrane protein [Function unknown]; Region: COG2860 401473003243 UPF0126 domain; Region: UPF0126; pfam03458 401473003244 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 401473003245 GTP-binding protein LepA; Provisional; Region: PRK05433 401473003246 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 401473003247 G1 box; other site 401473003248 putative GEF interaction site [polypeptide binding]; other site 401473003249 GTP/Mg2+ binding site [chemical binding]; other site 401473003250 Switch I region; other site 401473003251 G2 box; other site 401473003252 G3 box; other site 401473003253 Switch II region; other site 401473003254 G4 box; other site 401473003255 G5 box; other site 401473003256 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 401473003257 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 401473003258 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 401473003259 coproporphyrinogen III oxidase; Validated; Region: PRK05628 401473003260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401473003261 FeS/SAM binding site; other site 401473003262 HemN C-terminal domain; Region: HemN_C; pfam06969 401473003263 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 401473003264 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 401473003265 active site 401473003266 dimer interface [polypeptide binding]; other site 401473003267 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 401473003268 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 401473003269 active site 401473003270 FMN binding site [chemical binding]; other site 401473003271 substrate binding site [chemical binding]; other site 401473003272 3Fe-4S cluster binding site [ion binding]; other site 401473003273 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 401473003274 domain interface; other site 401473003275 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 401473003276 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 401473003277 photosystem II protein J; Region: psbJ; CHL00108 401473003278 glycogen synthase, Corynebacterium family; Region: glgA_Coryne; TIGR02149 401473003279 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 401473003280 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 401473003281 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473003282 Walker A/P-loop; other site 401473003283 ATP binding site [chemical binding]; other site 401473003284 Q-loop/lid; other site 401473003285 ABC transporter signature motif; other site 401473003286 Walker B; other site 401473003287 D-loop; other site 401473003288 H-loop/switch region; other site 401473003289 tRNA(1-methyladenosine) methyltransferase and related methyltransferases [Translation, ribosomal structure and biogenesis]; Region: GCD14; COG2519 401473003290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401473003291 S-adenosylmethionine binding site [chemical binding]; other site 401473003292 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473003293 catalytic core [active] 401473003294 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 401473003295 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 401473003296 THF binding site; other site 401473003297 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 401473003298 substrate binding site [chemical binding]; other site 401473003299 THF binding site; other site 401473003300 zinc-binding site [ion binding]; other site 401473003301 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 401473003302 FAD binding site [chemical binding]; other site 401473003303 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14109 401473003304 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 401473003305 metal binding triad; other site 401473003306 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 401473003307 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 401473003308 metal binding triad; other site 401473003309 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 401473003310 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 401473003311 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 401473003312 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 401473003313 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 401473003314 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 401473003315 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 401473003316 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 401473003317 dihydroorotase; Validated; Region: pyrC; PRK09357 401473003318 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 401473003319 active site 401473003320 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 401473003321 active site 401473003322 dimer interface [polypeptide binding]; other site 401473003323 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 401473003324 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 401473003325 FAD binding pocket [chemical binding]; other site 401473003326 FAD binding motif [chemical binding]; other site 401473003327 phosphate binding motif [ion binding]; other site 401473003328 beta-alpha-beta structure motif; other site 401473003329 NAD binding pocket [chemical binding]; other site 401473003330 Iron coordination center [ion binding]; other site 401473003331 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 401473003332 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 401473003333 heterodimer interface [polypeptide binding]; other site 401473003334 active site 401473003335 FMN binding site [chemical binding]; other site 401473003336 homodimer interface [polypeptide binding]; other site 401473003337 substrate binding site [chemical binding]; other site 401473003338 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401473003339 active site 401473003340 Pseudo-gene of Transcriptional regulator, LysR family (in-frame stop codon) 401473003341 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 401473003342 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473003343 motif II; other site 401473003344 Peptidase C26; Region: Peptidase_C26; pfam07722 401473003345 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 401473003346 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 401473003347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473003348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473003349 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473003350 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473003351 Walker A/P-loop; other site 401473003352 ATP binding site [chemical binding]; other site 401473003353 Q-loop/lid; other site 401473003354 ABC transporter signature motif; other site 401473003355 Walker B; other site 401473003356 D-loop; other site 401473003357 H-loop/switch region; other site 401473003358 Elongation factor TS; Region: EF_TS; pfam00889 401473003359 Occludin homology domain; Region: Occludin_ELL; pfam07303 401473003360 FtsX-like permease family; Region: FtsX; pfam02687 401473003361 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473003362 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 401473003363 FtsX-like permease family; Region: FtsX; pfam02687 401473003364 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 401473003365 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 401473003366 putative substrate binding site [chemical binding]; other site 401473003367 putative ATP binding site [chemical binding]; other site 401473003368 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473003369 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473003370 Walker A/P-loop; other site 401473003371 ATP binding site [chemical binding]; other site 401473003372 Q-loop/lid; other site 401473003373 ABC transporter signature motif; other site 401473003374 Walker B; other site 401473003375 D-loop; other site 401473003376 H-loop/switch region; other site 401473003377 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 401473003378 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 401473003379 active site 401473003380 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 401473003381 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 401473003382 DNA binding residues [nucleotide binding] 401473003383 putative dimer interface [polypeptide binding]; other site 401473003384 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 401473003385 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 401473003386 catalytic Zn binding site [ion binding]; other site 401473003387 NAD(P) binding site [chemical binding]; other site 401473003388 structural Zn binding site [ion binding]; other site 401473003389 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 401473003390 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 401473003391 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 401473003392 substrate binding site [chemical binding]; other site 401473003393 THF binding site; other site 401473003394 zinc-binding site [ion binding]; other site 401473003395 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 401473003396 active site 401473003397 catalytic triad [active] 401473003398 oxyanion hole [active] 401473003399 Cation efflux family; Region: Cation_efflux; pfam01545 401473003400 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 401473003401 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401473003402 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401473003403 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401473003404 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 401473003405 ATP-binding cassette domain of non-transporter proteins; Region: ABC_Class2; cd03227 401473003406 Walker A/P-loop; other site 401473003407 ATP binding site [chemical binding]; other site 401473003408 Q-loop/lid; other site 401473003409 ABC transporter signature motif; other site 401473003410 Walker B; other site 401473003411 D-loop; other site 401473003412 H-loop/switch region; other site 401473003413 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 401473003414 Isochorismatase family; Region: Isochorismatase; pfam00857 401473003415 catalytic triad [active] 401473003416 metal binding site [ion binding]; metal-binding site 401473003417 conserved cis-peptide bond; other site 401473003418 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473003419 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 401473003420 malate dehydrogenase; Provisional; Region: PRK13529 401473003421 Malic enzyme, N-terminal domain; Region: malic; pfam00390 401473003422 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 401473003423 NAD(P) binding site [chemical binding]; other site 401473003424 A new structural DNA glycosylase; Region: AlkD_like; cd06561 401473003425 active site 401473003426 Predicted membrane protein [Function unknown]; Region: COG2364 401473003427 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 401473003428 VanZ like family; Region: VanZ; pfam04892 401473003429 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 401473003430 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 401473003431 Domain of unknown function (DUF4194); Region: DUF4194; pfam13835 401473003432 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913 401473003433 P-loop containing region of AAA domain; Region: AAA_29; pfam13555 401473003434 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 401473003435 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 401473003436 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 401473003437 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 401473003438 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 401473003439 excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671 401473003440 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 401473003441 GIY-YIG motif/motif A; other site 401473003442 active site 401473003443 catalytic site [active] 401473003444 putative DNA binding site [nucleotide binding]; other site 401473003445 metal binding site [ion binding]; metal-binding site 401473003446 UvrB/uvrC motif; Region: UVR; pfam02151 401473003447 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 401473003448 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 401473003449 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 401473003450 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 401473003451 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 401473003452 shikimate binding site; other site 401473003453 NAD(P) binding site [chemical binding]; other site 401473003454 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 401473003455 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 401473003456 Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650 401473003457 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 401473003458 Phosphoglycerate kinase; Region: PGK; pfam00162 401473003459 substrate binding site [chemical binding]; other site 401473003460 hinge regions; other site 401473003461 ADP binding site [chemical binding]; other site 401473003462 catalytic site [active] 401473003463 Similar to ISBlo3 imperfect TIRs 401473003464 Helix-turn-helix domain; Region: HTH_28; pfam13518 401473003465 Transposase; Region: HTH_Tnp_1; cl17663 401473003466 Integrase core domain; Region: rve; pfam00665 401473003467 DDE domain; Region: DDE_Tnp_IS240; pfam13610 401473003468 Integrase core domain; Region: rve_2; pfam13333 401473003469 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 401473003470 triosephosphate isomerase; Provisional; Region: PRK14567 401473003471 substrate binding site [chemical binding]; other site 401473003472 dimer interface [polypeptide binding]; other site 401473003473 catalytic triad [active] 401473003474 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 401473003475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 401473003476 active site 401473003477 motif I; other site 401473003478 motif II; other site 401473003479 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 401473003480 bifunctional HTH-domain containing protein/aminotransferase; Provisional; Region: PRK13355 401473003481 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401473003482 non-specific DNA binding site [nucleotide binding]; other site 401473003483 salt bridge; other site 401473003484 sequence-specific DNA binding site [nucleotide binding]; other site 401473003485 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473003486 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473003487 homodimer interface [polypeptide binding]; other site 401473003488 catalytic residue [active] 401473003489 Transaldolase-like proteins from plants and bacteria; Region: Transaldolase_like; cd00955 401473003490 putative active site [active] 401473003491 transaldolase; Provisional; Region: PRK03903 401473003492 catalytic residue [active] 401473003493 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 401473003494 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 401473003495 TPP-binding site [chemical binding]; other site 401473003496 dimer interface [polypeptide binding]; other site 401473003497 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 401473003498 PYR/PP interface [polypeptide binding]; other site 401473003499 dimer interface [polypeptide binding]; other site 401473003500 TPP binding site [chemical binding]; other site 401473003501 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 401473003502 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 401473003503 HTH domain; Region: HTH_11; pfam08279 401473003504 chaperone protein DnaJ; Provisional; Region: PRK14278 401473003505 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 401473003506 HSP70 interaction site [polypeptide binding]; other site 401473003507 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 401473003508 Zn binding sites [ion binding]; other site 401473003509 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 401473003510 dimer interface [polypeptide binding]; other site 401473003511 Fructosamine kinase; Region: Fructosamin_kin; cl17579 401473003512 Phosphotransferase enzyme family; Region: APH; pfam01636 401473003513 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554 401473003514 PAC2 family; Region: PAC2; pfam09754 401473003515 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 401473003516 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 401473003517 phosphopeptide binding site; other site 401473003518 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 401473003519 DNA binding residues [nucleotide binding] 401473003520 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 401473003521 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 401473003522 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473003523 motif II; other site 401473003524 Domain of unknown function (DUF4109); Region: DUF4109; pfam13397 401473003525 DEAD-like helicases superfamily; Region: DEXDc; smart00487 401473003526 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473003527 ATP binding site [chemical binding]; other site 401473003528 putative Mg++ binding site [ion binding]; other site 401473003529 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473003530 nucleotide binding region [chemical binding]; other site 401473003531 ATP-binding site [chemical binding]; other site 401473003532 DSHCT (NUC185) domain; Region: DSHCT; pfam08148 401473003533 Predicted transcriptional regulator [Transcription]; Region: COG2378 401473003534 WYL domain; Region: WYL; pfam13280 401473003535 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 401473003536 active site 401473003537 bifunctional cytidylate kinase/GTPase Der; Reviewed; Region: PRK09518 401473003538 AAA domain; Region: AAA_17; pfam13207 401473003539 Cytidylate kinase; Region: Cytidylate_kin; pfam02224 401473003540 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 401473003541 G1 box; other site 401473003542 GTP/Mg2+ binding site [chemical binding]; other site 401473003543 Switch I region; other site 401473003544 G2 box; other site 401473003545 Switch II region; other site 401473003546 G3 box; other site 401473003547 G4 box; other site 401473003548 G5 box; other site 401473003549 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 401473003550 G1 box; other site 401473003551 GTP/Mg2+ binding site [chemical binding]; other site 401473003552 Switch I region; other site 401473003553 G2 box; other site 401473003554 G3 box; other site 401473003555 Switch II region; other site 401473003556 G4 box; other site 401473003557 G5 box; other site 401473003558 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 401473003559 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401473003560 RNA binding surface [nucleotide binding]; other site 401473003561 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 401473003562 active site 401473003563 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 401473003564 amphipathic channel; other site 401473003565 Asn-Pro-Ala signature motifs; other site 401473003566 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 401473003567 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 401473003568 purine monophosphate binding site [chemical binding]; other site 401473003569 dimer interface [polypeptide binding]; other site 401473003570 putative catalytic residues [active] 401473003571 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 401473003572 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 401473003573 CoA binding domain; Region: CoA_binding; pfam02629 401473003574 CoA-ligase; Region: Ligase_CoA; pfam00549 401473003575 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 401473003576 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 401473003577 CoA-ligase; Region: Ligase_CoA; pfam00549 401473003578 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401473003579 active site 401473003580 Preprotein translocase subunit; Region: YajC; cl00806 401473003581 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 401473003582 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473003583 Walker A motif; other site 401473003584 ATP binding site [chemical binding]; other site 401473003585 Walker B motif; other site 401473003586 arginine finger; other site 401473003587 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 401473003588 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 401473003589 Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase; cl00205 401473003590 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 401473003591 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 401473003592 active site 401473003593 putative DNA-binding cleft [nucleotide binding]; other site 401473003594 dimer interface [polypeptide binding]; other site 401473003595 hypothetical protein; Validated; Region: PRK00110 401473003596 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401473003597 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 401473003598 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 401473003599 putative acyl-acceptor binding pocket; other site 401473003600 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 401473003601 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 401473003602 thiS-thiF/thiG interaction site; other site 401473003603 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 401473003604 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 401473003605 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 401473003606 active site 401473003607 dimer interface [polypeptide binding]; other site 401473003608 motif 1; other site 401473003609 motif 2; other site 401473003610 motif 3; other site 401473003611 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 401473003612 anticodon binding site; other site 401473003613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879 401473003614 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 401473003615 Protein of unknown function (DUF1290); Region: DUF1290; pfam06947 401473003616 Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949 401473003617 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 401473003618 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 401473003619 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 401473003620 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 401473003621 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Mycobacterium tuberculosis phosphoribosyl-ATP pyrophosphohydrolase (HisE or PRATP-PH) and its bacterial homologs; Region: NTP-PPase_HisE; cd11547 401473003622 homodimer interface [polypeptide binding]; other site 401473003623 putative metal binding site [ion binding]; other site 401473003624 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 401473003625 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 401473003626 substrate binding site [chemical binding]; other site 401473003627 hexamer interface [polypeptide binding]; other site 401473003628 metal binding site [ion binding]; metal-binding site 401473003629 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 401473003630 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 401473003631 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 401473003632 substrate binding site [chemical binding]; other site 401473003633 active site 401473003634 catalytic residues [active] 401473003635 heterodimer interface [polypeptide binding]; other site 401473003636 bifunctional indole-3-glycerol phosphate synthase/tryptophan synthase subunit beta; Provisional; Region: PRK13802 401473003637 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 401473003638 active site 401473003639 ribulose/triose binding site [chemical binding]; other site 401473003640 phosphate binding site [ion binding]; other site 401473003641 substrate (anthranilate) binding pocket [chemical binding]; other site 401473003642 product (indole) binding pocket [chemical binding]; other site 401473003643 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 401473003644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473003645 catalytic residue [active] 401473003646 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 401473003647 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 401473003648 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 401473003649 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 401473003650 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 401473003651 substrate binding site [chemical binding]; other site 401473003652 glutamase interaction surface [polypeptide binding]; other site 401473003653 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14459 401473003654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401473003655 FeS/SAM binding site; other site 401473003656 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 401473003657 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 401473003658 ribosome recycling factor; Reviewed; Region: frr; PRK00083 401473003659 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 401473003660 hinge region; other site 401473003661 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 401473003662 putative nucleotide binding site [chemical binding]; other site 401473003663 uridine monophosphate binding site [chemical binding]; other site 401473003664 homohexameric interface [polypeptide binding]; other site 401473003665 elongation factor Ts; Provisional; Region: tsf; PRK09377 401473003666 UBA/TS-N domain; Region: UBA; pfam00627 401473003667 Elongation factor TS; Region: EF_TS; pfam00889 401473003668 Elongation factor TS; Region: EF_TS; pfam00889 401473003669 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 401473003670 rRNA interaction site [nucleotide binding]; other site 401473003671 S8 interaction site; other site 401473003672 putative laminin-1 binding site; other site 401473003673 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 401473003674 active site 401473003675 catalytic residues [active] 401473003676 metal binding site [ion binding]; metal-binding site 401473003677 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 401473003678 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 401473003679 acyl-activating enzyme (AAE) consensus motif; other site 401473003680 putative AMP binding site [chemical binding]; other site 401473003681 putative active site [active] 401473003682 putative CoA binding site [chemical binding]; other site 401473003683 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK08649 401473003684 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 401473003685 active site 401473003686 isocitrate dehydrogenase; Validated; Region: PRK08299 401473003687 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 401473003688 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 401473003689 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 401473003690 acyl-activating enzyme (AAE) consensus motif; other site 401473003691 putative AMP binding site [chemical binding]; other site 401473003692 putative active site [active] 401473003693 putative CoA binding site [chemical binding]; other site 401473003694 UGMP family protein; Validated; Region: PRK09604 401473003695 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 401473003696 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 401473003697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401473003698 Coenzyme A binding pocket [chemical binding]; other site 401473003699 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 401473003700 Glycoprotease family; Region: Peptidase_M22; pfam00814 401473003701 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 401473003702 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 401473003703 Competence protein; Region: Competence; pfam03772 401473003704 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 401473003705 Helix-hairpin-helix motif; Region: HHH; pfam00633 401473003706 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 401473003707 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 401473003708 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401473003709 active site 401473003710 HIGH motif; other site 401473003711 nucleotide binding site [chemical binding]; other site 401473003712 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 401473003713 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401473003714 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401473003715 active site 401473003716 KMSKS motif; other site 401473003717 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 401473003718 tRNA binding surface [nucleotide binding]; other site 401473003719 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401473003720 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 401473003721 substrate binding pocket [chemical binding]; other site 401473003722 membrane-bound complex binding site; other site 401473003723 hinge residues; other site 401473003724 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 401473003725 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 401473003726 Cl binding site [ion binding]; other site 401473003727 oligomer interface [polypeptide binding]; other site 401473003728 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473003729 catalytic core [active] 401473003730 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 401473003731 Histidine kinase; Region: His_kinase; pfam06580 401473003732 Response regulator receiver domain; Region: Response_reg; pfam00072 401473003733 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473003734 active site 401473003735 phosphorylation site [posttranslational modification] 401473003736 intermolecular recognition site; other site 401473003737 dimerization interface [polypeptide binding]; other site 401473003738 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 401473003739 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 401473003740 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473003741 catalytic core [active] 401473003742 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 401473003743 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14352 401473003744 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 401473003745 Substrate binding site; other site 401473003746 Mg++ binding site; other site 401473003747 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 401473003748 active site 401473003749 substrate binding site [chemical binding]; other site 401473003750 CoA binding site [chemical binding]; other site 401473003751 Isoleucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: IleS; COG0060 401473003752 GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439 401473003753 GIY-YIG motif/motif A; other site 401473003754 putative active site [active] 401473003755 putative metal binding site [ion binding]; other site 401473003756 AAA domain; Region: AAA_30; pfam13604 401473003757 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 401473003758 Uncharacterized conserved protein [Function unknown]; Region: COG3410 401473003759 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 401473003760 Zeta toxin; Region: Zeta_toxin; pfam06414 401473003761 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 401473003762 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 401473003763 active site 401473003764 catalytic site [active] 401473003765 substrate binding site [chemical binding]; other site 401473003766 Domain of unknown function (DUF955); Region: DUF955; cl01076 401473003767 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cl11442 401473003768 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 401473003769 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 401473003770 CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865 401473003771 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483 401473003772 Protein of unknown function (DUF499); Region: DUF499; pfam04465 401473003773 Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743 401473003774 Protein of unknown function (DUF1156); Region: DUF1156; pfam06634 401473003775 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 401473003776 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 401473003777 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473003778 ATP binding site [chemical binding]; other site 401473003779 putative Mg++ binding site [ion binding]; other site 401473003780 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 401473003781 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473003782 nucleotide binding region [chemical binding]; other site 401473003783 ATP-binding site [chemical binding]; other site 401473003784 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 401473003785 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 401473003786 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 401473003787 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401473003788 active site 401473003789 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 401473003790 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 401473003791 active site 401473003792 (T/H)XGH motif; other site 401473003793 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 401473003794 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 401473003795 putative catalytic cysteine [active] 401473003796 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 401473003797 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 401473003798 dimer interface [polypeptide binding]; other site 401473003799 active site 401473003800 glycine-pyridoxal phosphate binding site [chemical binding]; other site 401473003801 folate binding site [chemical binding]; other site 401473003802 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 401473003803 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 401473003804 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473003805 catalytic residue [active] 401473003806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473003807 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473003808 putative substrate translocation pore; other site 401473003809 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473003810 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473003811 DNA binding site [nucleotide binding] 401473003812 domain linker motif; other site 401473003813 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473003814 dimerization interface [polypeptide binding]; other site 401473003815 ligand binding site [chemical binding]; other site 401473003816 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473003817 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 401473003818 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473003819 dimer interface [polypeptide binding]; other site 401473003820 conserved gate region; other site 401473003821 putative PBP binding loops; other site 401473003822 ABC-ATPase subunit interface; other site 401473003823 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473003824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473003825 dimer interface [polypeptide binding]; other site 401473003826 conserved gate region; other site 401473003827 putative PBP binding loops; other site 401473003828 ABC-ATPase subunit interface; other site 401473003829 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 401473003830 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_ox_2; pfam12900 401473003831 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 401473003832 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 401473003833 Predicted transcriptional regulators [Transcription]; Region: COG1725 401473003834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 401473003835 DNA-binding site [nucleotide binding]; DNA binding site 401473003836 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 401473003837 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473003838 motif II; other site 401473003839 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 401473003840 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473003841 Walker A/P-loop; other site 401473003842 ATP binding site [chemical binding]; other site 401473003843 Q-loop/lid; other site 401473003844 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 401473003845 ABC transporter signature motif; other site 401473003846 Walker B; other site 401473003847 D-loop; other site 401473003848 H-loop/switch region; other site 401473003849 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03372 401473003850 ATP-NAD kinase; Region: NAD_kinase; pfam01513 401473003851 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 401473003852 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 401473003853 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 401473003854 TrkA-N domain; Region: TrkA_N; pfam02254 401473003855 TrkA-C domain; Region: TrkA_C; pfam02080 401473003856 FtsJ-like methyltransferase; Region: FtsJ; cl17430 401473003857 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 401473003858 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 401473003859 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473003860 motif II; other site 401473003861 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 401473003862 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 401473003863 active site 401473003864 HIGH motif; other site 401473003865 dimer interface [polypeptide binding]; other site 401473003866 KMSKS motif; other site 401473003867 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 401473003868 RNA binding surface [nucleotide binding]; other site 401473003869 Protein of unknown function (DUF975); Region: DUF975; cl10504 401473003870 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 401473003871 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 401473003872 Predicted membrane protein [Function unknown]; Region: COG4905 401473003873 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 401473003874 Zn2+ binding site [ion binding]; other site 401473003875 Mg2+ binding site [ion binding]; other site 401473003876 argininosuccinate lyase; Provisional; Region: PRK00855 401473003877 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 401473003878 active sites [active] 401473003879 tetramer interface [polypeptide binding]; other site 401473003880 argininosuccinate synthase; Provisional; Region: PRK13820 401473003881 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 401473003882 ANP binding site [chemical binding]; other site 401473003883 Substrate Binding Site II [chemical binding]; other site 401473003884 Substrate Binding Site I [chemical binding]; other site 401473003885 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 401473003886 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 401473003887 ornithine carbamoyltransferase; Provisional; Region: PRK00779 401473003888 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 401473003889 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 401473003890 acetylornithine aminotransferase; Provisional; Region: argD; PRK03244 401473003891 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 401473003892 inhibitor-cofactor binding pocket; inhibition site 401473003893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473003894 catalytic residue [active] 401473003895 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 401473003896 feedback inhibition sensing region; other site 401473003897 homohexameric interface [polypeptide binding]; other site 401473003898 nucleotide binding site [chemical binding]; other site 401473003899 N-acetyl-L-glutamate binding site [chemical binding]; other site 401473003900 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 401473003901 heterotetramer interface [polypeptide binding]; other site 401473003902 active site pocket [active] 401473003903 cleavage site 401473003904 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 401473003905 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 401473003906 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 401473003907 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 401473003908 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 401473003909 putative tRNA-binding site [nucleotide binding]; other site 401473003910 B3/4 domain; Region: B3_4; pfam03483 401473003911 tRNA synthetase B5 domain; Region: B5; pfam03484 401473003912 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 401473003913 dimer interface [polypeptide binding]; other site 401473003914 motif 1; other site 401473003915 motif 3; other site 401473003916 motif 2; other site 401473003917 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 401473003918 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 401473003919 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 401473003920 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 401473003921 dimer interface [polypeptide binding]; other site 401473003922 motif 1; other site 401473003923 active site 401473003924 motif 2; other site 401473003925 motif 3; other site 401473003926 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 401473003927 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 401473003928 FtsX-like permease family; Region: FtsX; pfam02687 401473003929 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473003930 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473003931 Walker A/P-loop; other site 401473003932 ATP binding site [chemical binding]; other site 401473003933 Q-loop/lid; other site 401473003934 ABC transporter signature motif; other site 401473003935 Walker B; other site 401473003936 D-loop; other site 401473003937 H-loop/switch region; other site 401473003938 hypothetical protein; Provisional; Region: PRK07907 401473003939 M20 Dipeptidases; Region: M20_Dipept_like; cd03893 401473003940 active site 401473003941 metal binding site [ion binding]; metal-binding site 401473003942 dimer interface [polypeptide binding]; other site 401473003943 Protein of unknown function (DUF3043); Region: DUF3043; pfam11241 401473003944 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 401473003945 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 401473003946 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401473003947 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 401473003948 Domain of unknown function (DUF4191); Region: DUF4191; pfam13829 401473003949 glutamine synthetase, type I; Region: GlnA; TIGR00653 401473003950 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 401473003951 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 401473003952 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 401473003953 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473003954 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 401473003955 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 401473003956 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 401473003957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473003958 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 401473003959 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 401473003960 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401473003961 EcoEI R protein C-terminal; Region: EcoEI_R_C; pfam08463 401473003962 Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098 401473003963 catalytic site [active] 401473003964 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473003965 H-loop/switch region; other site 401473003966 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 401473003967 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 401473003968 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 401473003969 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 401473003970 Walker A/P-loop; other site 401473003971 ATP binding site [chemical binding]; other site 401473003972 Q-loop/lid; other site 401473003973 ABC transporter signature motif; other site 401473003974 Walker B; other site 401473003975 D-loop; other site 401473003976 H-loop/switch region; other site 401473003977 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 401473003978 Walker A/P-loop; other site 401473003979 ATP binding site [chemical binding]; other site 401473003980 Q-loop/lid; other site 401473003981 ABC transporter signature motif; other site 401473003982 Walker B; other site 401473003983 D-loop; other site 401473003984 H-loop/switch region; other site 401473003985 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819 401473003986 Domain of unknown function DUF59; Region: DUF59; cl00941 401473003987 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 401473003988 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 401473003989 Walker A motif; other site 401473003990 Ligase N family; Region: LIGANc; smart00532 401473003991 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 401473003992 nucleotide binding pocket [chemical binding]; other site 401473003993 K-X-D-G motif; other site 401473003994 catalytic site [active] 401473003995 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 401473003996 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 401473003997 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 401473003998 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 401473003999 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 401473004000 Dimer interface [polypeptide binding]; other site 401473004001 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 401473004002 binding surface 401473004003 TPR motif; other site 401473004004 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 401473004005 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 401473004006 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473004007 Walker A/P-loop; other site 401473004008 ATP binding site [chemical binding]; other site 401473004009 Q-loop/lid; other site 401473004010 ABC transporter signature motif; other site 401473004011 Walker B; other site 401473004012 D-loop; other site 401473004013 H-loop/switch region; other site 401473004014 tyrosine aminotransferase; Provisional; Region: PTZ00433 401473004015 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473004016 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473004017 homodimer interface [polypeptide binding]; other site 401473004018 catalytic residue [active] 401473004019 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401473004020 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401473004021 nucleotide binding site [chemical binding]; other site 401473004022 Predicted membrane protein [Function unknown]; Region: COG3601 401473004023 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 401473004024 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 401473004025 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 401473004026 Walker A/P-loop; other site 401473004027 ATP binding site [chemical binding]; other site 401473004028 Q-loop/lid; other site 401473004029 ABC transporter signature motif; other site 401473004030 Walker B; other site 401473004031 D-loop; other site 401473004032 H-loop/switch region; other site 401473004033 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 401473004034 Walker A/P-loop; other site 401473004035 ATP binding site [chemical binding]; other site 401473004036 Q-loop/lid; other site 401473004037 ABC transporter signature motif; other site 401473004038 Walker B; other site 401473004039 D-loop; other site 401473004040 H-loop/switch region; other site 401473004041 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 401473004042 Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228 401473004043 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 401473004044 Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299 401473004045 active site 401473004046 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 401473004047 Putative transcription activator [Transcription]; Region: TenA; COG0819 401473004048 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 401473004049 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 401473004050 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473004051 ATP binding site [chemical binding]; other site 401473004052 putative Mg++ binding site [ion binding]; other site 401473004053 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473004054 nucleotide binding region [chemical binding]; other site 401473004055 ATP-binding site [chemical binding]; other site 401473004056 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 401473004057 trimer interface [polypeptide binding]; other site 401473004058 active site 401473004059 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: PRK12334 401473004060 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 401473004061 homodimer interface [polypeptide binding]; other site 401473004062 metal binding site [ion binding]; metal-binding site 401473004063 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 401473004064 Excalibur calcium-binding domain; Region: Excalibur; smart00894 401473004065 Ion channel; Region: Ion_trans_2; pfam07885 401473004066 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 401473004067 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143 401473004068 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 401473004069 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 401473004070 NAD binding site [chemical binding]; other site 401473004071 ligand binding site [chemical binding]; other site 401473004072 catalytic site [active] 401473004073 Protein of unknown function, DUF488; Region: DUF488; cl01246 401473004074 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 401473004075 putative active site [active] 401473004076 dimerization interface [polypeptide binding]; other site 401473004077 putative tRNAtyr binding site [nucleotide binding]; other site 401473004078 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473004079 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473004080 short chain dehydrogenase; Provisional; Region: PRK08226 401473004081 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401473004082 NAD(P) binding site [chemical binding]; other site 401473004083 active site 401473004084 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 401473004085 6-hydroxycyclohex-1-ene-1-carboxyl-CoA dehydrogenase, N-benzyl-3-pyrrolidinol dehydrogenase, and other MDR family members; Region: hydroxyacyl_CoA_DH; cd08254 401473004086 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 401473004087 catalytic Zn binding site [ion binding]; other site 401473004088 putative NAD(P) binding site [chemical binding]; other site 401473004089 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 401473004090 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cl00253 401473004091 putative active site [active] 401473004092 dimerization interface [polypeptide binding]; other site 401473004093 putative tRNAtyr binding site [nucleotide binding]; other site 401473004094 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 401473004095 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 401473004096 active site 401473004097 purine riboside binding site [chemical binding]; other site 401473004098 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 401473004099 putative ADP-ribose binding site [chemical binding]; other site 401473004100 putative active site [active] 401473004101 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 401473004102 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 401473004103 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 401473004104 catalytic site [active] 401473004105 metal binding site [ion binding]; metal-binding site 401473004106 AAA ATPase domain; Region: AAA_16; pfam13191 401473004107 Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848 401473004108 Uncharacterized conserved protein [Function unknown]; Region: COG3410 401473004109 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 401473004110 homodimer interface [polypeptide binding]; other site 401473004111 chemical substrate binding site [chemical binding]; other site 401473004112 oligomer interface [polypeptide binding]; other site 401473004113 metal binding site [ion binding]; metal-binding site 401473004114 CAAX protease self-immunity; Region: Abi; pfam02517 401473004115 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 401473004116 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 401473004117 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 401473004118 Uncharacterized conserved protein [Function unknown]; Region: COG1434 401473004119 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 401473004120 putative active site [active] 401473004121 DNA polymerase III subunit epsilon; Provisional; Region: PRK06063 401473004122 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 401473004123 active site 401473004124 catalytic site [active] 401473004125 substrate binding site [chemical binding]; other site 401473004126 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 401473004127 Dimer interface [polypeptide binding]; other site 401473004128 BRCT sequence motif; other site 401473004129 trigger factor; Provisional; Region: tig; PRK01490 401473004130 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 401473004131 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 401473004132 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 401473004133 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 401473004134 active site 401473004135 catalytic site [active] 401473004136 substrate binding site [chemical binding]; other site 401473004137 HRDC domain; Region: HRDC; pfam00570 401473004138 Protein of unknown function (DUF3000); Region: DUF3000; pfam11452 401473004139 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 401473004140 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401473004141 FeS/SAM binding site; other site 401473004142 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 401473004143 Pyruvate formate lyase 1; Region: PFL1; cd01678 401473004144 coenzyme A binding site [chemical binding]; other site 401473004145 active site 401473004146 catalytic residues [active] 401473004147 glycine loop; other site 401473004148 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 401473004149 H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610 401473004150 fructuronate transporter; Provisional; Region: PRK10034; cl15264 401473004151 Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835 401473004152 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 401473004153 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 401473004154 NAD synthetase; Provisional; Region: PRK13981 401473004155 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 401473004156 multimer interface [polypeptide binding]; other site 401473004157 active site 401473004158 catalytic triad [active] 401473004159 protein interface 1 [polypeptide binding]; other site 401473004160 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 401473004161 homodimer interface [polypeptide binding]; other site 401473004162 NAD binding pocket [chemical binding]; other site 401473004163 ATP binding pocket [chemical binding]; other site 401473004164 Mg binding site [ion binding]; other site 401473004165 active-site loop [active] 401473004166 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 401473004167 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 401473004168 metal binding site [ion binding]; metal-binding site 401473004169 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473004170 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 401473004171 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 401473004172 Walker A/P-loop; other site 401473004173 ATP binding site [chemical binding]; other site 401473004174 Q-loop/lid; other site 401473004175 ABC transporter signature motif; other site 401473004176 Walker B; other site 401473004177 D-loop; other site 401473004178 H-loop/switch region; other site 401473004179 NIL domain; Region: NIL; cl09633 401473004180 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 401473004181 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 401473004182 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 401473004183 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473004184 active site 401473004185 motif I; other site 401473004186 motif II; other site 401473004187 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473004188 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 401473004189 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 401473004190 Tubulin/FtsZ: Family includes tubulin alpha-, beta-, gamma-, delta-, and epsilon-tubulins as well as FtsZ, all of which are involved in polymer formation. Tubulin is the major component of microtubules, but also exists as a heterodimer and as a curved...; Region: Tubulin_FtsZ; cl10017 401473004191 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 401473004192 GIY-YIG motif/motif A; other site 401473004193 putative active site [active] 401473004194 putative metal binding site [ion binding]; other site 401473004195 putative transposase OrfB; Reviewed; Region: PHA02517 401473004196 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria; Region: GIY-YIG_unchar_1; cd10446 401473004197 GIY-YIG motif/motif A; other site 401473004198 putative active site [active] 401473004199 putative metal binding site [ion binding]; other site 401473004200 Similar to ISBlo10 12/10bp TIRs 401473004201 Integrase core domain; Region: rve_3; cl15866 401473004202 Protein of unknown function (DUF2699); Region: DUF2699; pfam10919 401473004203 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 401473004204 active site 401473004205 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 401473004206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 401473004207 Zn2+ binding site [ion binding]; other site 401473004208 Mg2+ binding site [ion binding]; other site 401473004209 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 401473004210 synthetase active site [active] 401473004211 NTP binding site [chemical binding]; other site 401473004212 metal binding site [ion binding]; metal-binding site 401473004213 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 401473004214 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 401473004215 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 401473004216 trimer interface [polypeptide binding]; other site 401473004217 active site 401473004218 Domain of unknown function (DUF4193); Region: DUF4193; pfam13834 401473004219 Protein of unknown function (DUF3071); Region: DUF3071; pfam11268 401473004220 Uncharacterized conserved protein [Function unknown]; Region: COG3379 401473004221 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 401473004222 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 401473004223 CAP-like domain; other site 401473004224 active site 401473004225 primary dimer interface [polypeptide binding]; other site 401473004226 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 401473004227 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473004228 ATP binding site [chemical binding]; other site 401473004229 putative Mg++ binding site [ion binding]; other site 401473004230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473004231 nucleotide binding region [chemical binding]; other site 401473004232 ATP-binding site [chemical binding]; other site 401473004233 DEAD/H associated; Region: DEAD_assoc; pfam08494 401473004234 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401473004235 salt bridge; other site 401473004236 non-specific DNA binding site [nucleotide binding]; other site 401473004237 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 401473004238 sequence-specific DNA binding site [nucleotide binding]; other site 401473004239 Protein of unknown function (DUF3036); Region: DUF3036; pfam11234 401473004240 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 401473004241 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 401473004242 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473004243 putative substrate translocation pore; other site 401473004244 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473004245 Mg2+ binding site [ion binding]; other site 401473004246 G-X-G motif; other site 401473004247 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 401473004248 anchoring element; other site 401473004249 dimer interface [polypeptide binding]; other site 401473004250 ATP binding site [chemical binding]; other site 401473004251 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 401473004252 active site 401473004253 putative metal-binding site [ion binding]; other site 401473004254 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 401473004255 RNA polymerase sigma factor SigB; Reviewed; Region: PRK07921 401473004256 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 401473004257 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 401473004258 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 401473004259 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 401473004260 DNA binding residues [nucleotide binding] 401473004261 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 401473004262 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 401473004263 substrate binding pocket [chemical binding]; other site 401473004264 chain length determination region; other site 401473004265 substrate-Mg2+ binding site; other site 401473004266 catalytic residues [active] 401473004267 aspartate-rich region 1; other site 401473004268 active site lid residues [active] 401473004269 aspartate-rich region 2; other site 401473004270 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 401473004271 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 401473004272 active site 401473004273 ATP binding site [chemical binding]; other site 401473004274 substrate binding site [chemical binding]; other site 401473004275 activation loop (A-loop); other site 401473004276 PASTA domain; Region: PASTA; pfam03793 401473004277 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 401473004278 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 401473004279 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 401473004280 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 401473004281 putative acyl-acceptor binding pocket; other site 401473004282 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 401473004283 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 401473004284 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 401473004285 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 401473004286 DEAD/DEAH box helicase; Region: DEAD; pfam00270 401473004287 ATP binding site [chemical binding]; other site 401473004288 putative Mg++ binding site [ion binding]; other site 401473004289 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 401473004290 SEC-C motif; Region: SEC-C; pfam02810 401473004291 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cl00250 401473004292 30S subunit binding site; other site 401473004293 RecX family; Region: RecX; pfam02631 401473004294 recombinase A; Provisional; Region: recA; PRK09354 401473004295 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 401473004296 hexamer interface [polypeptide binding]; other site 401473004297 Walker A motif; other site 401473004298 ATP binding site [chemical binding]; other site 401473004299 Walker B motif; other site 401473004300 Protein of unknown function (DUF3046); Region: DUF3046; pfam11248 401473004301 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401473004302 non-specific DNA binding site [nucleotide binding]; other site 401473004303 salt bridge; other site 401473004304 sequence-specific DNA binding site [nucleotide binding]; other site 401473004305 Competence-damaged protein; Region: CinA; pfam02464 401473004306 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 401473004307 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 401473004308 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 401473004309 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 401473004310 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 401473004311 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 401473004312 Carbohydrate binding domain (family 11); Region: CBM_11; pfam03425 401473004313 Fic/DOC family; Region: Fic; cl00960 401473004314 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 401473004315 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 401473004316 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14326 401473004317 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 401473004318 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401473004319 FeS/SAM binding site; other site 401473004320 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 401473004321 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 401473004322 synthetase active site [active] 401473004323 NTP binding site [chemical binding]; other site 401473004324 metal binding site [ion binding]; metal-binding site 401473004325 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 401473004326 EamA-like transporter family; Region: EamA; pfam00892 401473004327 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 401473004328 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 401473004329 Protein of unknown function DUF262; Region: DUF262; pfam03235 401473004330 Uncharacterized conserved protein [Function unknown]; Region: COG1479 401473004331 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 401473004332 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 401473004333 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473004334 active site 401473004335 phosphorylation site [posttranslational modification] 401473004336 intermolecular recognition site; other site 401473004337 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 401473004338 DNA binding residues [nucleotide binding] 401473004339 dimerization interface [polypeptide binding]; other site 401473004340 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 401473004341 Histidine kinase; Region: HisKA_3; pfam07730 401473004342 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 401473004343 ATP binding site [chemical binding]; other site 401473004344 Mg2+ binding site [ion binding]; other site 401473004345 G-X-G motif; other site 401473004346 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 401473004347 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 401473004348 Walker A/P-loop; other site 401473004349 ATP binding site [chemical binding]; other site 401473004350 Q-loop/lid; other site 401473004351 ABC transporter signature motif; other site 401473004352 Walker B; other site 401473004353 D-loop; other site 401473004354 H-loop/switch region; other site 401473004355 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 401473004356 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 401473004357 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 401473004358 Cupin domain; Region: Cupin_2; cl17218 401473004359 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 401473004360 maltose O-acetyltransferase; Provisional; Region: PRK10092 401473004361 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 401473004362 active site 401473004363 substrate binding site [chemical binding]; other site 401473004364 trimer interface [polypeptide binding]; other site 401473004365 CoA binding site [chemical binding]; other site 401473004366 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 401473004367 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134 401473004368 aconitate hydratase; Validated; Region: PRK09277 401473004369 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 401473004370 substrate binding site [chemical binding]; other site 401473004371 ligand binding site [chemical binding]; other site 401473004372 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 401473004373 substrate binding site [chemical binding]; other site 401473004374 Bdent2 401473004375 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 401473004376 DNA binding site [nucleotide binding] 401473004377 Int/Topo IB signature motif; other site 401473004378 active site 401473004379 catalytic residues [active] 401473004380 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 401473004381 nucleotide binding site [chemical binding]; other site 401473004382 polymerase nucleotide-binding site; other site 401473004383 primase nucleotide-binding site [nucleotide binding]; other site 401473004384 DNA-binding residues [nucleotide binding]; DNA binding site 401473004385 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 401473004386 conjugal transfer coupling protein TraG; Provisional; Region: PRK13822 401473004387 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 401473004388 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 401473004389 Phage capsid family; Region: Phage_capsid; pfam05065 401473004390 Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355 401473004391 tape measure domain; Region: tape_meas_nterm; TIGR02675 401473004392 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 401473004393 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 401473004394 active site 401473004395 catalytic triad [active] 401473004396 oxyanion hole [active] 401473004397 LysA is a cell wall endolysin produced by Lactobacillus fermentum, which degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. The N-terminal glycosyl hydrolase...; Region: GH25_LysA-like; cd06417 401473004398 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 401473004399 active site 401473004400 Cpl-7 lysozyme C-terminal domain; Region: Cpl-7; cl07020 401473004401 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 401473004402 Helix-turn-helix domain; Region: HTH_17; pfam12728 401473004403 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 401473004404 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 401473004405 cofactor binding site; other site 401473004406 DNA binding site [nucleotide binding] 401473004407 substrate interaction site [chemical binding]; other site 401473004408 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 401473004409 Helix-turn-helix domain; Region: HTH_17; pfam12728 401473004410 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 401473004411 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 401473004412 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 401473004413 active site 401473004414 motif I; other site 401473004415 motif II; other site 401473004416 NADH dehydrogenase subunit 6; Provisional; Region: ND6; cl17624 401473004417 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 401473004418 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 401473004419 TRAM domain; Region: TRAM; cl01282 401473004420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401473004421 S-adenosylmethionine binding site [chemical binding]; other site 401473004422 Protein of unknown function (DUF3159); Region: DUF3159; pfam11361 401473004423 Protein of unknown function (DUF3710); Region: DUF3710; pfam12502 401473004424 Neisseria meningitides Nape-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Nape_like_AP-endo; cd10281 401473004425 putative active site [active] 401473004426 putative DNA binding site [nucleotide binding]; other site 401473004427 metal binding site A [ion binding]; metal-binding site 401473004428 putative catalytic site [active] 401473004429 putative phosphate binding site [ion binding]; other site 401473004430 putative AP binding site [nucleotide binding]; other site 401473004431 putative metal binding site B [ion binding]; other site 401473004432 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 401473004433 AAA domain; Region: AAA_21; pfam13304 401473004434 Walker A/P-loop; other site 401473004435 ATP binding site [chemical binding]; other site 401473004436 Q-loop/lid; other site 401473004437 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 401473004438 ABC transporter signature motif; other site 401473004439 Walker B; other site 401473004440 D-loop; other site 401473004441 H-loop/switch region; other site 401473004442 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 401473004443 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 401473004444 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 401473004445 Walker A/P-loop; other site 401473004446 ATP binding site [chemical binding]; other site 401473004447 Q-loop/lid; other site 401473004448 ABC transporter signature motif; other site 401473004449 Walker B; other site 401473004450 D-loop; other site 401473004451 H-loop/switch region; other site 401473004452 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 401473004453 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 401473004454 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 401473004455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473004456 dimer interface [polypeptide binding]; other site 401473004457 conserved gate region; other site 401473004458 putative PBP binding loops; other site 401473004459 ABC-ATPase subunit interface; other site 401473004460 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 401473004461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473004462 dimer interface [polypeptide binding]; other site 401473004463 conserved gate region; other site 401473004464 putative PBP binding loops; other site 401473004465 ABC-ATPase subunit interface; other site 401473004466 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 401473004467 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 401473004468 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 401473004469 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 401473004470 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 401473004471 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 401473004472 active site 401473004473 DNA binding site [nucleotide binding] 401473004474 Int/Topo IB signature motif; other site 401473004475 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473004476 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473004477 Walker A/P-loop; other site 401473004478 ATP binding site [chemical binding]; other site 401473004479 Q-loop/lid; other site 401473004480 ABC transporter signature motif; other site 401473004481 Walker B; other site 401473004482 D-loop; other site 401473004483 H-loop/switch region; other site 401473004484 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473004485 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 401473004486 FtsX-like permease family; Region: FtsX; pfam02687 401473004487 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473004488 FtsX-like permease family; Region: FtsX; pfam02687 401473004489 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 401473004490 prephenate dehydrogenase; Validated; Region: PRK08507 401473004491 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 401473004492 Prephenate dehydratase; Region: PDT; pfam00800 401473004493 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 401473004494 putative L-Phe binding site [chemical binding]; other site 401473004495 GTP-binding protein TypA/BipA; Region: TypA_BipA; TIGR01394 401473004496 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 401473004497 G1 box; other site 401473004498 putative GEF interaction site [polypeptide binding]; other site 401473004499 GTP/Mg2+ binding site [chemical binding]; other site 401473004500 Switch I region; other site 401473004501 G2 box; other site 401473004502 G3 box; other site 401473004503 Switch II region; other site 401473004504 G4 box; other site 401473004505 G5 box; other site 401473004506 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 401473004507 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 401473004508 Helix-turn-helix domain; Region: HTH_28; pfam13518 401473004509 Transposase; Region: HTH_Tnp_1; cl17663 401473004510 Similar to ISBlo3. no TIRS detected 401473004511 Integrase core domain; Region: rve; pfam00665 401473004512 DDE domain; Region: DDE_Tnp_IS240; pfam13610 401473004513 Integrase core domain; Region: rve_2; pfam13333 401473004514 benzoate transport; Region: 2A0115; TIGR00895 401473004515 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473004516 putative substrate translocation pore; other site 401473004517 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 401473004518 nudix motif; other site 401473004519 Uncharacterized conserved protein [General function prediction only]; Region: COG4111 401473004520 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 401473004521 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 401473004522 P-loop; other site 401473004523 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 401473004524 Magnesium ion binding site [ion binding]; other site 401473004525 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 401473004526 Magnesium ion binding site [ion binding]; other site 401473004527 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 401473004528 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 401473004529 active site 401473004530 Int/Topo IB signature motif; other site 401473004531 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 401473004532 23S rRNA binding site [nucleotide binding]; other site 401473004533 L21 binding site [polypeptide binding]; other site 401473004534 L13 binding site [polypeptide binding]; other site 401473004535 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 401473004536 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 401473004537 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 401473004538 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 401473004539 Asparagine synthase (glutamine-hydrolyzing) [Amino acid transport and metabolism]; Region: AsnB; COG0367 401473004540 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 401473004541 active site 401473004542 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 401473004543 Ligand Binding Site [chemical binding]; other site 401473004544 Molecular Tunnel; other site 401473004545 Thiamine pyrophosphokinase; Region: TPK; cd07995 401473004546 active site 401473004547 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 401473004548 dimerization interface [polypeptide binding]; other site 401473004549 thiamine binding site [chemical binding]; other site 401473004550 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 401473004551 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 401473004552 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 401473004553 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 401473004554 putative deacylase active site [active] 401473004555 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 401473004556 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 401473004557 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 401473004558 active site 401473004559 catalytic residues [active] 401473004560 RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino 401473004561 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 401473004562 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 401473004563 DNA binding residues [nucleotide binding] 401473004564 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 401473004565 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401473004566 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401473004567 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401473004568 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 401473004569 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401473004570 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401473004571 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401473004572 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 401473004573 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 401473004574 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 401473004575 aspartate racemase; Region: asp_race; TIGR00035 401473004576 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 401473004577 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401473004578 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401473004579 proline aminopeptidase P II; Provisional; Region: PRK10879 401473004580 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 401473004581 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 401473004582 active site 401473004583 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_17; cd04676 401473004584 nudix motif; other site 401473004585 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 401473004586 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 401473004587 Walker A/P-loop; other site 401473004588 ATP binding site [chemical binding]; other site 401473004589 Q-loop/lid; other site 401473004590 ABC transporter signature motif; other site 401473004591 Walker B; other site 401473004592 D-loop; other site 401473004593 H-loop/switch region; other site 401473004594 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 401473004595 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 401473004596 Walker A/P-loop; other site 401473004597 ATP binding site [chemical binding]; other site 401473004598 Q-loop/lid; other site 401473004599 ABC transporter signature motif; other site 401473004600 Walker B; other site 401473004601 D-loop; other site 401473004602 H-loop/switch region; other site 401473004603 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 401473004604 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 401473004605 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 401473004606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473004607 dimer interface [polypeptide binding]; other site 401473004608 conserved gate region; other site 401473004609 ABC-ATPase subunit interface; other site 401473004610 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 401473004611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473004612 dimer interface [polypeptide binding]; other site 401473004613 conserved gate region; other site 401473004614 putative PBP binding loops; other site 401473004615 ABC-ATPase subunit interface; other site 401473004616 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 401473004617 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 401473004618 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 401473004619 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 401473004620 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401473004621 putative DNA binding site [nucleotide binding]; other site 401473004622 Transcriptional regulators [Transcription]; Region: MarR; COG1846 401473004623 putative Zn2+ binding site [ion binding]; other site 401473004624 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401473004625 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401473004626 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 401473004627 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 401473004628 putative substrate binding site [chemical binding]; other site 401473004629 putative ATP binding site [chemical binding]; other site 401473004630 Uncharacterized conserved protein [Function unknown]; Region: COG3538 401473004631 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 401473004632 dimerization interface [polypeptide binding]; other site 401473004633 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 401473004634 putative active cleft [active] 401473004635 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 401473004636 Cell division protein FtsQ; Region: FtsQ; pfam03799 401473004637 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 401473004638 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401473004639 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401473004640 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401473004641 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 401473004642 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 401473004643 homodimer interface [polypeptide binding]; other site 401473004644 active site 401473004645 cell division protein FtsW; Region: ftsW; TIGR02614 401473004646 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01438 401473004647 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401473004648 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 401473004649 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 401473004650 Mg++ binding site [ion binding]; other site 401473004651 putative catalytic motif [active] 401473004652 putative substrate binding site [chemical binding]; other site 401473004653 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 401473004654 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 401473004655 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 401473004656 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 401473004657 putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929 401473004658 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 401473004659 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 401473004660 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 401473004661 MraW methylase family; Region: Methyltransf_5; cl17771 401473004662 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 401473004663 MraZ protein; Region: MraZ; pfam02381 401473004664 cell division protein MraZ; Reviewed; Region: PRK00326 401473004665 MraZ protein; Region: MraZ; pfam02381 401473004666 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 401473004667 Part of AAA domain; Region: AAA_19; pfam13245 401473004668 Family description; Region: UvrD_C_2; pfam13538 401473004669 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 401473004670 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 401473004671 ligand binding site [chemical binding]; other site 401473004672 NAD binding site [chemical binding]; other site 401473004673 tetramer interface [polypeptide binding]; other site 401473004674 catalytic site [active] 401473004675 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 401473004676 L-serine binding site [chemical binding]; other site 401473004677 ACT domain interface; other site 401473004678 ATP cone domain; Region: ATP-cone; pfam03477 401473004679 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 401473004680 LexA repressor; Validated; Region: PRK00215 401473004681 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 401473004682 Catalytic site [active] 401473004683 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 401473004684 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 401473004685 A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292 401473004686 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 401473004687 NAD binding site [chemical binding]; other site 401473004688 dimer interface [polypeptide binding]; other site 401473004689 substrate binding site [chemical binding]; other site 401473004690 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401473004691 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 401473004692 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 401473004693 HflX GTPase family; Region: HflX; cd01878 401473004694 G1 box; other site 401473004695 GTP/Mg2+ binding site [chemical binding]; other site 401473004696 Switch I region; other site 401473004697 G2 box; other site 401473004698 G3 box; other site 401473004699 Switch II region; other site 401473004700 G4 box; other site 401473004701 G5 box; other site 401473004702 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 401473004703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401473004704 S-adenosylmethionine binding site [chemical binding]; other site 401473004705 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 401473004706 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473004707 ATP binding site [chemical binding]; other site 401473004708 putative Mg++ binding site [ion binding]; other site 401473004709 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473004710 nucleotide binding region [chemical binding]; other site 401473004711 ATP-binding site [chemical binding]; other site 401473004712 Helicase associated domain (HA2); Region: HA2; pfam04408 401473004713 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 401473004714 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 401473004715 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 401473004716 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473004717 putative substrate translocation pore; other site 401473004718 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 401473004719 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 401473004720 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 401473004721 type VII secretion protein EccCa; Region: T7SS_EccC_a; TIGR03924 401473004722 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 401473004723 type VII secretion protein EccCb; Region: T7SS_EccC_b; TIGR03925 401473004724 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 401473004725 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 401473004726 RDD family; Region: RDD; pfam06271 401473004727 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 401473004728 phosphopeptide binding site; other site 401473004729 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 401473004730 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cd00306 401473004731 active site 401473004732 catalytic residues [active] 401473004733 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 401473004734 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489 401473004735 Protein of unknown function (DUF690); Region: DUF690; cl04939 401473004736 type VII secretion-associated serine protease mycosin; Region: T7SS_mycosin; TIGR03921 401473004737 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 401473004738 active site 401473004739 catalytic residues [active] 401473004740 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 401473004741 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 401473004742 catalytic residues [active] 401473004743 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 401473004744 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 401473004745 putative active site [active] 401473004746 oxyanion strand; other site 401473004747 catalytic triad [active] 401473004748 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 401473004749 putative active site pocket [active] 401473004750 4-fold oligomerization interface [polypeptide binding]; other site 401473004751 metal binding residues [ion binding]; metal-binding site 401473004752 3-fold/trimer interface [polypeptide binding]; other site 401473004753 histidinol-phosphate aminotransferase; Provisional; Region: PRK03317 401473004754 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473004755 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473004756 homodimer interface [polypeptide binding]; other site 401473004757 catalytic residue [active] 401473004758 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 401473004759 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 401473004760 NAD binding site [chemical binding]; other site 401473004761 dimerization interface [polypeptide binding]; other site 401473004762 product binding site; other site 401473004763 substrate binding site [chemical binding]; other site 401473004764 zinc binding site [ion binding]; other site 401473004765 catalytic residues [active] 401473004766 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473004767 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473004768 putative substrate translocation pore; other site 401473004769 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 401473004770 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 401473004771 active site 401473004772 PHP Thumb interface [polypeptide binding]; other site 401473004773 metal binding site [ion binding]; metal-binding site 401473004774 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 401473004775 generic binding surface II; other site 401473004776 generic binding surface I; other site 401473004777 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 401473004778 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 401473004779 active site 401473004780 lipoprotein signal peptidase; Provisional; Region: PRK14771 401473004781 YGGT family; Region: YGGT; pfam02325 401473004782 Protein of unknown function (DUF552); Region: DUF552; pfam04472 401473004783 cell division protein FtsZ; Validated; Region: PRK09330 401473004784 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 401473004785 nucleotide binding site [chemical binding]; other site 401473004786 SulA interaction site; other site 401473004787 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 401473004788 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 401473004789 FMN binding site [chemical binding]; other site 401473004790 active site 401473004791 catalytic residues [active] 401473004792 substrate binding site [chemical binding]; other site 401473004793 glycyl-tRNA synthetase; Provisional; Region: PRK04173 401473004794 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 401473004795 active site 401473004796 motif 2; other site 401473004797 motif 3; other site 401473004798 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 401473004799 anticodon binding site; other site 401473004800 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401473004801 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 401473004802 active site 401473004803 catalytic tetrad [active] 401473004804 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 401473004805 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 401473004806 DNA binding residues [nucleotide binding] 401473004807 putative dimer interface [polypeptide binding]; other site 401473004808 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 401473004809 substrate binding site [chemical binding]; other site 401473004810 multimerization interface [polypeptide binding]; other site 401473004811 ATP binding site [chemical binding]; other site 401473004812 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 401473004813 active site 401473004814 thiamine phosphate binding site [chemical binding]; other site 401473004815 pyrophosphate binding site [ion binding]; other site 401473004816 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 401473004817 ThiC-associated domain; Region: ThiC-associated; pfam13667 401473004818 ThiC family; Region: ThiC; pfam01964 401473004819 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 401473004820 dimer interface [polypeptide binding]; other site 401473004821 substrate binding site [chemical binding]; other site 401473004822 ATP binding site [chemical binding]; other site 401473004823 Domain of unknown function DUF77; Region: DUF77; pfam01910 401473004824 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473004825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473004826 DNA binding site [nucleotide binding] 401473004827 domain linker motif; other site 401473004828 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 401473004829 putative dimerization interface [polypeptide binding]; other site 401473004830 putative ligand binding site [chemical binding]; other site 401473004831 galactoside permease; Reviewed; Region: lacY; PRK09528 401473004832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473004833 putative substrate translocation pore; other site 401473004834 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 401473004835 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 401473004836 substrate binding [chemical binding]; other site 401473004837 active site 401473004838 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 401473004839 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 401473004840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473004841 active site 401473004842 phosphorylation site [posttranslational modification] 401473004843 intermolecular recognition site; other site 401473004844 dimerization interface [polypeptide binding]; other site 401473004845 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 401473004846 DNA binding residues [nucleotide binding] 401473004847 dimerization interface [polypeptide binding]; other site 401473004848 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cd00172 401473004849 serpin-like protein; Provisional; Region: PHA02660 401473004850 reactive center loop; other site 401473004851 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 401473004852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473004853 dimer interface [polypeptide binding]; other site 401473004854 conserved gate region; other site 401473004855 putative PBP binding loops; other site 401473004856 ABC-ATPase subunit interface; other site 401473004857 NMT1/THI5 like; Region: NMT1; pfam09084 401473004858 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 401473004859 active site 401473004860 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 401473004861 undecaprenyl pyrophosphate synthase; Provisional; Region: PRK14829 401473004862 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 401473004863 catalytic residue [active] 401473004864 putative FPP diphosphate binding site; other site 401473004865 putative FPP binding hydrophobic cleft; other site 401473004866 dimer interface [polypeptide binding]; other site 401473004867 putative IPP diphosphate binding site; other site 401473004868 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 401473004869 Recombination protein O N terminal; Region: RecO_N; pfam11967 401473004870 Recombination protein O C terminal; Region: RecO_C; pfam02565 401473004871 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 401473004872 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 401473004873 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 401473004874 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 401473004875 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 401473004876 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 401473004877 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 401473004878 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 401473004879 DivIVA domain repeat protein; Region: divI1A_rptt_fam; TIGR03543 401473004880 DivIVA domain; Region: DivI1A_domain; TIGR03544 401473004881 Predicted transcriptional regulators [Transcription]; Region: COG1733 401473004882 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 401473004883 Protein of unknown function (DUF3052); Region: DUF3052; pfam11253 401473004884 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 401473004885 Uncharacterized conserved protein (DUF2342); Region: DUF2342; pfam10103 401473004886 UvrD/REP helicase N-terminal domain; Region: UvrD-helicase; pfam00580 401473004887 Part of AAA domain; Region: AAA_19; pfam13245 401473004888 Family description; Region: UvrD_C_2; pfam13538 401473004889 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 401473004890 Phosphotransferase enzyme family; Region: APH; pfam01636 401473004891 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 401473004892 substrate binding site [chemical binding]; other site 401473004893 Protein of unknown function (DUF3107); Region: DUF3107; pfam11305 401473004894 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 401473004895 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 401473004896 Vitamin K epoxide reductase family in bacteria; Region: VKOR_5; cd12922 401473004897 putative active site [active] 401473004898 redox center [active] 401473004899 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 401473004900 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 401473004901 glutamate racemase; Provisional; Region: PRK00865 401473004902 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 401473004903 nucleophile elbow; other site 401473004904 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 401473004905 active site 401473004906 DNA binding site [nucleotide binding] 401473004907 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 401473004908 putative hydrolase; Provisional; Region: PRK11460 401473004909 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401473004910 sequence-specific DNA binding site [nucleotide binding]; other site 401473004911 salt bridge; other site 401473004912 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401473004913 non-specific DNA binding site [nucleotide binding]; other site 401473004914 salt bridge; other site 401473004915 sequence-specific DNA binding site [nucleotide binding]; other site 401473004916 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 401473004917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401473004918 non-specific DNA binding site [nucleotide binding]; other site 401473004919 salt bridge; other site 401473004920 sequence-specific DNA binding site [nucleotide binding]; other site 401473004921 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 401473004922 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 401473004923 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040 401473004924 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 401473004925 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 401473004926 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 401473004927 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 401473004928 AAA domain; Region: AAA_14; pfam13173 401473004929 AAA domain; Region: AAA_22; pfam13401 401473004930 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 401473004931 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 401473004932 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 401473004933 HIGH motif; other site 401473004934 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 401473004935 active site 401473004936 KMSKS motif; other site 401473004937 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 401473004938 tRNA binding surface [nucleotide binding]; other site 401473004939 anticodon binding site; other site 401473004940 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 401473004941 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473004942 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 401473004943 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 401473004944 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 401473004945 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 401473004946 Beta galactosidase small chain; Region: Bgal_small_N; smart01038 401473004947 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473004948 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473004949 DNA binding site [nucleotide binding] 401473004950 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 401473004951 putative ligand binding site [chemical binding]; other site 401473004952 putative dimerization interface [polypeptide binding]; other site 401473004953 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 401473004954 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473004955 putative substrate translocation pore; other site 401473004956 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 401473004957 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401473004958 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 401473004959 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 401473004960 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 401473004961 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401473004962 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 401473004963 Walker A/P-loop; other site 401473004964 ATP binding site [chemical binding]; other site 401473004965 Q-loop/lid; other site 401473004966 ABC transporter signature motif; other site 401473004967 Walker B; other site 401473004968 D-loop; other site 401473004969 H-loop/switch region; other site 401473004970 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401473004971 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401473004972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473004973 Walker A/P-loop; other site 401473004974 ATP binding site [chemical binding]; other site 401473004975 Q-loop/lid; other site 401473004976 ABC transporter signature motif; other site 401473004977 Walker B; other site 401473004978 D-loop; other site 401473004979 H-loop/switch region; other site 401473004980 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 401473004981 MarR family; Region: MarR_2; pfam12802 401473004982 maltose O-acetyltransferase; Provisional; Region: PRK10092 401473004983 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 401473004984 active site 401473004985 substrate binding site [chemical binding]; other site 401473004986 trimer interface [polypeptide binding]; other site 401473004987 CoA binding site [chemical binding]; other site 401473004988 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 401473004989 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 401473004990 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 401473004991 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473004992 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473004993 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473004994 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 401473004995 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 401473004996 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 401473004997 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473004998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473004999 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 401473005000 classical (c) SDRs; Region: SDR_c; cd05233 401473005001 NAD(P) binding site [chemical binding]; other site 401473005002 active site 401473005003 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 401473005004 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 401473005005 DNA binding residues [nucleotide binding] 401473005006 drug binding residues [chemical binding]; other site 401473005007 dimer interface [polypeptide binding]; other site 401473005008 Bacterial PH domain; Region: DUF304; pfam03703 401473005009 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005010 putative substrate translocation pore; other site 401473005011 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473005012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005013 Transcriptional regulators [Transcription]; Region: MarR; COG1846 401473005014 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 401473005015 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 401473005016 MFS/sugar transport protein; Region: MFS_2; pfam13347 401473005017 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 401473005018 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473005019 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473005020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005021 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473005022 putative substrate translocation pore; other site 401473005023 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 401473005024 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 401473005025 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473005026 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473005027 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473005028 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 401473005029 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473005030 ATP binding site [chemical binding]; other site 401473005031 Mg2+ binding site [ion binding]; other site 401473005032 G-X-G motif; other site 401473005033 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 401473005034 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473005035 active site 401473005036 phosphorylation site [posttranslational modification] 401473005037 intermolecular recognition site; other site 401473005038 dimerization interface [polypeptide binding]; other site 401473005039 LytTr DNA-binding domain; Region: LytTR; pfam04397 401473005040 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 401473005041 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473005042 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 401473005043 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 401473005044 Beta-xylosidase [Carbohydrate transport and metabolism]; Region: XynB; COG3507 401473005045 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 401473005046 inhibitor binding site; inhibition site 401473005047 active site 401473005048 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 401473005049 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 401473005050 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 401473005051 O-Glycosyl hydrolase family 30; Region: Glyco_hydro_30; pfam02055 401473005052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005053 putative substrate translocation pore; other site 401473005054 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473005055 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473005056 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 401473005057 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 401473005058 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473005059 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473005060 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470 401473005061 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473005062 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473005063 DNA binding site [nucleotide binding] 401473005064 domain linker motif; other site 401473005065 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 401473005066 putative dimerization interface [polypeptide binding]; other site 401473005067 putative ligand binding site [chemical binding]; other site 401473005068 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 401473005069 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 401473005070 NADP binding site [chemical binding]; other site 401473005071 homodimer interface [polypeptide binding]; other site 401473005072 active site 401473005073 fructuronate transporter; Provisional; Region: PRK10034; cl15264 401473005074 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 401473005075 potential frameshift: common BLAST hit: gi|189440793|ref|YP_001955874.1| Activator of 2-hydroxyglutaryl-CoA dehydratase 401473005076 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 401473005077 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 401473005078 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 401473005079 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 401473005080 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 401473005081 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 401473005082 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 401473005083 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 401473005084 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 401473005085 FeS/SAM binding site; other site 401473005086 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 401473005087 ATP cone domain; Region: ATP-cone; pfam03477 401473005088 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 401473005089 Class III ribonucleotide reductase; Region: RNR_III; cd01675 401473005090 active site 401473005091 Zn binding site [ion binding]; other site 401473005092 glycine loop; other site 401473005093 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 401473005094 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 401473005095 generic binding surface II; other site 401473005096 generic binding surface I; other site 401473005097 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 401473005098 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 401473005099 putative catalytic site [active] 401473005100 putative metal binding site [ion binding]; other site 401473005101 putative phosphate binding site [ion binding]; other site 401473005102 NADH(P)-binding; Region: NAD_binding_10; pfam13460 401473005103 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401473005104 NAD(P) binding site [chemical binding]; other site 401473005105 active site 401473005106 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 401473005107 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 401473005108 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 401473005109 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 401473005110 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 401473005111 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473005112 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473005113 dimer interface [polypeptide binding]; other site 401473005114 conserved gate region; other site 401473005115 putative PBP binding loops; other site 401473005116 ABC-ATPase subunit interface; other site 401473005117 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 401473005118 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473005119 conserved gate region; other site 401473005120 putative PBP binding loops; other site 401473005121 ABC-ATPase subunit interface; other site 401473005122 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473005123 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 401473005124 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473005125 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473005126 DNA binding site [nucleotide binding] 401473005127 domain linker motif; other site 401473005128 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473005129 dimerization interface [polypeptide binding]; other site 401473005130 ligand binding site [chemical binding]; other site 401473005131 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 401473005132 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 401473005133 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005134 putative substrate translocation pore; other site 401473005135 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 401473005136 exopolyphosphatase; Region: exo_poly_only; TIGR03706 401473005137 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401473005138 nucleotide binding site [chemical binding]; other site 401473005139 aminotransferase; Validated; Region: PRK07337 401473005140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473005141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473005142 homodimer interface [polypeptide binding]; other site 401473005143 catalytic residue [active] 401473005144 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 401473005145 putative active site [active] 401473005146 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 401473005147 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 401473005148 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 401473005149 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 401473005150 PLD-like domain; Region: PLDc_2; pfam13091 401473005151 putative homodimer interface [polypeptide binding]; other site 401473005152 putative active site [active] 401473005153 catalytic site [active] 401473005154 DEAD-like helicases superfamily; Region: DEXDc; smart00487 401473005155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473005156 ATP binding site [chemical binding]; other site 401473005157 DNA phosphorothioation system restriction enzyme; Region: dnd_restrict_1; TIGR04095 401473005158 putative Mg++ binding site [ion binding]; other site 401473005159 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 401473005160 nucleotide binding region [chemical binding]; other site 401473005161 ATP-binding site [chemical binding]; other site 401473005162 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 401473005163 potential frameshift: common BLAST hit: gi|119026629|ref|YP_910474.1| beta-glucosidase-related glycosidase 401473005164 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 401473005165 potential frameshift: common BLAST hit: gi|256831712|ref|YP_003160439.1| Beta-glucosidase 401473005166 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473005167 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 401473005168 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 401473005169 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 401473005170 active site 401473005171 catalytic site [active] 401473005172 substrate binding site [chemical binding]; other site 401473005173 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 401473005174 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 401473005175 Zeta toxin; Region: Zeta_toxin; pfam06414 401473005176 5' nucleotidase, deoxy (Pyrimidine), cytosolic type C protein (NT5C); Region: NT5C; cl17836 401473005177 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 401473005178 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 401473005179 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 401473005180 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 401473005181 active site 401473005182 catalytic site [active] 401473005183 substrate binding site [chemical binding]; other site 401473005184 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 401473005185 tyrosine decarboxylase MnfA; Region: tyr_de_CO2_Arch; TIGR03812 401473005186 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473005187 catalytic residue [active] 401473005188 putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813 401473005189 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 401473005190 active site 401473005191 catalytic residues [active] 401473005192 metal binding site [ion binding]; metal-binding site 401473005193 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14318 401473005194 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 401473005195 active site 401473005196 substrate binding site [chemical binding]; other site 401473005197 metal binding site [ion binding]; metal-binding site 401473005198 aminopeptidase N, Streptomyces lividans type; Region: pepN_strep_liv; TIGR02412 401473005199 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_3; cd09602 401473005200 Zn binding site [ion binding]; other site 401473005201 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 401473005202 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 401473005203 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 401473005204 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 401473005205 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 401473005206 dimer interface [polypeptide binding]; other site 401473005207 active site 401473005208 catalytic residue [active] 401473005209 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 401473005210 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005211 putative substrate translocation pore; other site 401473005212 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 401473005213 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 401473005214 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 401473005215 Soluble P-type ATPase [General function prediction only]; Region: COG4087 401473005216 Uncharacterized conserved protein [Function unknown]; Region: COG3350 401473005217 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 401473005218 putative homodimer interface [polypeptide binding]; other site 401473005219 putative homotetramer interface [polypeptide binding]; other site 401473005220 putative allosteric switch controlling residues; other site 401473005221 putative metal binding site [ion binding]; other site 401473005222 putative homodimer-homodimer interface [polypeptide binding]; other site 401473005223 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 401473005224 dihydrodipicolinate reductase; Provisional; Region: PRK00048 401473005225 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 401473005226 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 401473005227 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473005228 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005229 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 401473005230 Coenzyme A binding pocket [chemical binding]; other site 401473005231 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 401473005232 Family description; Region: UvrD_C_2; pfam13538 401473005233 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 401473005234 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 401473005235 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 401473005236 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 401473005237 Protein of unknown function DUF86; Region: DUF86; cl01031 401473005238 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 401473005239 active site 401473005240 NTP binding site [chemical binding]; other site 401473005241 metal binding triad [ion binding]; metal-binding site 401473005242 antibiotic binding site [chemical binding]; other site 401473005243 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 401473005244 Catalytic domain of Protein Kinases; Region: PKc; cd00180 401473005245 active site 401473005246 ATP binding site [chemical binding]; other site 401473005247 substrate binding site [chemical binding]; other site 401473005248 activation loop (A-loop); other site 401473005249 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 401473005250 Interdomain contacts; other site 401473005251 Cytokine receptor motif; other site 401473005252 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 401473005253 Interdomain contacts; other site 401473005254 Cytokine receptor motif; other site 401473005255 MoxR-like ATPases [General function prediction only]; Region: COG0714 401473005256 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473005257 Walker A motif; other site 401473005258 ATP binding site [chemical binding]; other site 401473005259 Walker B motif; other site 401473005260 arginine finger; other site 401473005261 Protein of unknown function DUF58; Region: DUF58; pfam01882 401473005262 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 401473005263 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 401473005264 Serine/threonine protein phosphatase [Signal transduction mechanisms]; Region: PTC1; COG0631 401473005265 active site 401473005266 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 401473005267 phosphopeptide binding site; other site 401473005268 RNA polymerase beta' subunit; Region: rpoC1; CHL00018 401473005269 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 401473005270 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 401473005271 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 401473005272 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 401473005273 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 401473005274 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 401473005275 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 401473005276 DNA binding site [nucleotide binding] 401473005277 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 401473005278 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 401473005279 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 401473005280 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 401473005281 RPB1 interaction site [polypeptide binding]; other site 401473005282 RPB10 interaction site [polypeptide binding]; other site 401473005283 RPB11 interaction site [polypeptide binding]; other site 401473005284 RPB3 interaction site [polypeptide binding]; other site 401473005285 RPB12 interaction site [polypeptide binding]; other site 401473005286 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 401473005287 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 401473005288 minor groove reading motif; other site 401473005289 helix-hairpin-helix signature motif; other site 401473005290 substrate binding pocket [chemical binding]; other site 401473005291 active site 401473005292 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 401473005293 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 401473005294 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 401473005295 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 401473005296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005297 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473005298 putative substrate translocation pore; other site 401473005299 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005300 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401473005301 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 401473005302 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 401473005303 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 401473005304 substrate binding site [chemical binding]; other site 401473005305 hexamer interface [polypeptide binding]; other site 401473005306 metal binding site [ion binding]; metal-binding site 401473005307 D-allose kinase; Provisional; Region: PRK09698 401473005308 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401473005309 nucleotide binding site [chemical binding]; other site 401473005310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005311 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473005312 putative substrate translocation pore; other site 401473005313 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 401473005314 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 401473005315 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 401473005316 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 401473005317 Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085 401473005318 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 401473005319 dimer interface [polypeptide binding]; other site 401473005320 active site 401473005321 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 401473005322 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 401473005323 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 401473005324 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 401473005325 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 401473005326 Ligand binding site; other site 401473005327 Putative Catalytic site; other site 401473005328 DXD motif; other site 401473005329 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 401473005330 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 401473005331 quinone interaction residues [chemical binding]; other site 401473005332 active site 401473005333 catalytic residues [active] 401473005334 FMN binding site [chemical binding]; other site 401473005335 substrate binding site [chemical binding]; other site 401473005336 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 401473005337 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 401473005338 active site 401473005339 FMN binding site [chemical binding]; other site 401473005340 substrate binding site [chemical binding]; other site 401473005341 homotetramer interface [polypeptide binding]; other site 401473005342 catalytic residue [active] 401473005343 Transglycosylase; Region: Transgly; pfam00912 401473005344 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 401473005345 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 401473005346 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 401473005347 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 401473005348 ligand binding site [chemical binding]; other site 401473005349 flexible hinge region; other site 401473005350 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 401473005351 putative switch regulator; other site 401473005352 non-specific DNA interactions [nucleotide binding]; other site 401473005353 DNA binding site [nucleotide binding] 401473005354 sequence specific DNA binding site [nucleotide binding]; other site 401473005355 putative cAMP binding site [chemical binding]; other site 401473005356 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 401473005357 TM2 domain; Region: TM2; pfam05154 401473005358 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 401473005359 tartrate dehydrogenase; Region: TTC; TIGR02089 401473005360 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 401473005361 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 401473005362 Uncharacterized conserved protein [Function unknown]; Region: COG4850 401473005363 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 401473005364 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 401473005365 lipoyl attachment site [posttranslational modification]; other site 401473005366 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 401473005367 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 401473005368 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 401473005369 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 401473005370 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 401473005371 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 401473005372 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 401473005373 putative NADH binding site [chemical binding]; other site 401473005374 putative active site [active] 401473005375 nudix motif; other site 401473005376 putative metal binding site [ion binding]; other site 401473005377 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 401473005378 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 401473005379 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 401473005380 catalytic residues [active] 401473005381 Domain of unknown function (DUF348); Region: DUF348; pfam03990 401473005382 G5 domain; Region: G5; pfam07501 401473005383 lysozyme_like domain. This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222 401473005384 catalytic residue [active] 401473005385 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 401473005386 Low molecular weight phosphatase family; Region: LMWPc; cd00115 401473005387 active site 401473005388 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 401473005389 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401473005390 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 401473005391 putative ADP-binding pocket [chemical binding]; other site 401473005392 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 401473005393 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 401473005394 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 401473005395 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473005396 active site 401473005397 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 401473005398 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473005399 active site 401473005400 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 401473005401 active site 401473005402 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 401473005403 trimer interface [polypeptide binding]; other site 401473005404 active site 401473005405 substrate binding site [chemical binding]; other site 401473005406 CoA binding site [chemical binding]; other site 401473005407 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 401473005408 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 401473005409 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cd12082 401473005410 Acyltransferase family; Region: Acyl_transf_3; pfam01757 401473005411 putative glycosyl transferase; Provisional; Region: PRK10073 401473005412 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473005413 active site 401473005414 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 401473005415 Acyltransferase family; Region: Acyl_transf_3; pfam01757 401473005416 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 401473005417 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 401473005418 putative glycosyl transferase; Provisional; Region: PRK10073 401473005419 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473005420 active site 401473005421 Core-2/I-Branching enzyme; Region: Branch; pfam02485 401473005422 putative glycosyl transferase; Provisional; Region: PRK10073 401473005423 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473005424 active site 401473005425 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 401473005426 FMN binding site [chemical binding]; other site 401473005427 dimer interface [polypeptide binding]; other site 401473005428 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 401473005429 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 401473005430 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473005431 active site 401473005432 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473005433 active site 401473005434 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 401473005435 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 401473005436 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401473005437 putative ADP-binding pocket [chemical binding]; other site 401473005438 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401473005439 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401473005440 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 401473005441 putative glycosyl transferase; Provisional; Region: PRK10073 401473005442 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473005443 active site 401473005444 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 401473005445 active site 401473005446 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401473005447 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 401473005448 putative ADP-binding pocket [chemical binding]; other site 401473005449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401473005450 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 401473005451 putative ADP-binding pocket [chemical binding]; other site 401473005452 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 401473005453 trimer interface [polypeptide binding]; other site 401473005454 active site 401473005455 substrate binding site [chemical binding]; other site 401473005456 CoA binding site [chemical binding]; other site 401473005457 Chain length determinant protein; Region: Wzz; cl15801 401473005458 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 401473005459 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 401473005460 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 401473005461 Bacterial sugar transferase; Region: Bac_transf; cl00939 401473005462 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 401473005463 Bacterial sugar transferase; Region: Bac_transf; pfam02397 401473005464 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 401473005465 Chain length determinant protein; Region: Wzz; cl15801 401473005466 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 401473005467 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 401473005468 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 401473005469 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 401473005470 substrate binding site; other site 401473005471 tetramer interface; other site 401473005472 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 401473005473 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 401473005474 NAD binding site [chemical binding]; other site 401473005475 substrate binding site [chemical binding]; other site 401473005476 homodimer interface [polypeptide binding]; other site 401473005477 active site 401473005478 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 401473005479 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401473005480 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 401473005481 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 401473005482 Probable Catalytic site; other site 401473005483 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 401473005484 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 401473005485 classical (c) SDRs; Region: SDR_c; cd05233 401473005486 NAD(P) binding site [chemical binding]; other site 401473005487 active site 401473005488 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 401473005489 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase [Coenzyme metabolism]; Region: MenD; COG1165 401473005490 dimer interface [polypeptide binding]; other site 401473005491 tetramer interface [polypeptide binding]; other site 401473005492 PYR/PP interface [polypeptide binding]; other site 401473005493 TPP binding site [chemical binding]; other site 401473005494 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 401473005495 TPP-binding site; other site 401473005496 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 401473005497 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 401473005498 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 401473005499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 401473005500 salt bridge; other site 401473005501 non-specific DNA binding site [nucleotide binding]; other site 401473005502 sequence-specific DNA binding site [nucleotide binding]; other site 401473005503 HipA N-terminal domain; Region: Couple_hipA; pfam13657 401473005504 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 401473005505 HipA-like N-terminal domain; Region: HipA_N; pfam07805 401473005506 HipA-like C-terminal domain; Region: HipA_C; pfam07804 401473005507 AAA domain; Region: AAA_14; pfam13173 401473005508 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 401473005509 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 401473005510 active site 401473005511 catalytic site [active] 401473005512 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 401473005513 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 401473005514 Cna protein B-type domain; Region: Cna_B; pfam05738 401473005515 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 401473005516 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 401473005517 intersubunit interface [polypeptide binding]; other site 401473005518 YodA lipocalin-like domain; Region: YodA; pfam09223 401473005519 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 401473005520 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 401473005521 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 401473005522 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 401473005523 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 401473005524 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473005525 Walker A/P-loop; other site 401473005526 ATP binding site [chemical binding]; other site 401473005527 Q-loop/lid; other site 401473005528 ABC transporter signature motif; other site 401473005529 Walker B; other site 401473005530 D-loop; other site 401473005531 H-loop/switch region; other site 401473005532 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473005533 FtsX-like permease family; Region: FtsX; pfam02687 401473005534 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 401473005535 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473005536 FtsX-like permease family; Region: FtsX; pfam02687 401473005537 Low molecular weight phosphatase family; Region: LMWPc; cd00115 401473005538 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 401473005539 active site 401473005540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005541 putative substrate translocation pore; other site 401473005542 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005543 putative substrate translocation pore; other site 401473005544 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 401473005545 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 401473005546 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 401473005547 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 401473005548 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 401473005549 active site 401473005550 catalytic tetrad [active] 401473005551 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 401473005552 putative active site [active] 401473005553 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473005554 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473005555 DNA binding site [nucleotide binding] 401473005556 domain linker motif; other site 401473005557 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473005558 ligand binding site [chemical binding]; other site 401473005559 dimerization interface [polypeptide binding]; other site 401473005560 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 401473005561 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 401473005562 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 401473005563 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473005564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473005565 dimer interface [polypeptide binding]; other site 401473005566 conserved gate region; other site 401473005567 putative PBP binding loops; other site 401473005568 ABC-ATPase subunit interface; other site 401473005569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473005570 dimer interface [polypeptide binding]; other site 401473005571 conserved gate region; other site 401473005572 putative PBP binding loops; other site 401473005573 ABC-ATPase subunit interface; other site 401473005574 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473005575 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473005576 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 401473005577 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 401473005578 predicted active site [active] 401473005579 catalytic triad [active] 401473005580 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 401473005581 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 401473005582 active site 401473005583 multimer interface [polypeptide binding]; other site 401473005584 ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988 401473005585 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401473005586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473005587 Walker A/P-loop; other site 401473005588 ATP binding site [chemical binding]; other site 401473005589 Q-loop/lid; other site 401473005590 ABC transporter signature motif; other site 401473005591 Walker B; other site 401473005592 D-loop; other site 401473005593 H-loop/switch region; other site 401473005594 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401473005595 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473005596 Walker A/P-loop; other site 401473005597 ATP binding site [chemical binding]; other site 401473005598 Q-loop/lid; other site 401473005599 ABC transporter signature motif; other site 401473005600 Walker B; other site 401473005601 D-loop; other site 401473005602 H-loop/switch region; other site 401473005603 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 401473005604 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 401473005605 acyl-activating enzyme (AAE) consensus motif; other site 401473005606 putative AMP binding site [chemical binding]; other site 401473005607 putative active site [active] 401473005608 putative CoA binding site [chemical binding]; other site 401473005609 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 401473005610 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473005611 putative substrate translocation pore; other site 401473005612 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473005613 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473005614 DNA binding site [nucleotide binding] 401473005615 domain linker motif; other site 401473005616 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473005617 ligand binding site [chemical binding]; other site 401473005618 dimerization interface [polypeptide binding]; other site 401473005619 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 401473005620 active site 401473005621 tetramer interface [polypeptide binding]; other site 401473005622 L-arabinose isomerase; Provisional; Region: PRK02929 401473005623 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 401473005624 hexamer (dimer of trimers) interface [polypeptide binding]; other site 401473005625 trimer interface [polypeptide binding]; other site 401473005626 substrate binding site [chemical binding]; other site 401473005627 Mn binding site [ion binding]; other site 401473005628 L-ribulose-5-phosphate 4-epimerase; Validated; Region: PRK06557 401473005629 intersubunit interface [polypeptide binding]; other site 401473005630 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 401473005631 active site 401473005632 Zn2+ binding site [ion binding]; other site 401473005633 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 401473005634 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 401473005635 putative N- and C-terminal domain interface [polypeptide binding]; other site 401473005636 putative active site [active] 401473005637 MgATP binding site [chemical binding]; other site 401473005638 catalytic site [active] 401473005639 metal binding site [ion binding]; metal-binding site 401473005640 putative carbohydrate binding site [chemical binding]; other site 401473005641 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473005642 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473005643 DNA binding site [nucleotide binding] 401473005644 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 401473005645 ligand binding site [chemical binding]; other site 401473005646 dimerization interface (open form) [polypeptide binding]; other site 401473005647 dimerization interface (closed form) [polypeptide binding]; other site 401473005648 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 401473005649 putative active site [active] 401473005650 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 401473005651 dimer interface [polypeptide binding]; other site 401473005652 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 401473005653 nudix motif; other site 401473005654 homoserine kinase; Provisional; Region: PRK01212 401473005655 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 401473005656 homoserine dehydrogenase; Provisional; Region: PRK06349 401473005657 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 401473005658 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 401473005659 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 401473005660 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 401473005661 HPr interaction site; other site 401473005662 glycerol kinase (GK) interaction site [polypeptide binding]; other site 401473005663 active site 401473005664 phosphorylation site [posttranslational modification] 401473005665 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 401473005666 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 401473005667 catalytic residue [active] 401473005668 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 401473005669 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401473005670 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 401473005671 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 401473005672 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 401473005673 active site 401473005674 HIGH motif; other site 401473005675 KMSK motif region; other site 401473005676 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 401473005677 tRNA binding surface [nucleotide binding]; other site 401473005678 anticodon binding site; other site 401473005679 S-methylmethionine transporter; Provisional; Region: PRK11387 401473005680 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 401473005681 homotrimer interaction site [polypeptide binding]; other site 401473005682 putative active site [active] 401473005683 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 401473005684 putative active site; other site 401473005685 putative metal binding residues [ion binding]; other site 401473005686 signature motif; other site 401473005687 putative triphosphate binding site [ion binding]; other site 401473005688 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 401473005689 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 401473005690 Similar to ISBlo3 like 16bp perfect TIRs 401473005691 Helix-turn-helix domain; Region: HTH_28; pfam13518 401473005692 Transposase; Region: HTH_Tnp_1; cl17663 401473005693 Integrase core domain; Region: rve; pfam00665 401473005694 DDE domain; Region: DDE_Tnp_IS240; pfam13610 401473005695 Integrase core domain; Region: rve_2; pfam13333 401473005696 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473005697 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 401473005698 Walker A/P-loop; other site 401473005699 ATP binding site [chemical binding]; other site 401473005700 Q-loop/lid; other site 401473005701 ABC transporter signature motif; other site 401473005702 Walker B; other site 401473005703 D-loop; other site 401473005704 H-loop/switch region; other site 401473005705 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473005706 active site 401473005707 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 401473005708 phosphorylation site [posttranslational modification] 401473005709 intermolecular recognition site; other site 401473005710 dimerization interface [polypeptide binding]; other site 401473005711 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 401473005712 DNA binding residues [nucleotide binding] 401473005713 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 401473005714 hypothetical protein; Provisional; Region: PRK03298 401473005715 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 401473005716 gamma subunit interface [polypeptide binding]; other site 401473005717 epsilon subunit interface [polypeptide binding]; other site 401473005718 LBP interface [polypeptide binding]; other site 401473005719 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 401473005720 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 401473005721 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 401473005722 alpha subunit interaction interface [polypeptide binding]; other site 401473005723 Walker A motif; other site 401473005724 ATP binding site [chemical binding]; other site 401473005725 Walker B motif; other site 401473005726 inhibitor binding site; inhibition site 401473005727 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 401473005728 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 401473005729 core domain interface [polypeptide binding]; other site 401473005730 delta subunit interface [polypeptide binding]; other site 401473005731 epsilon subunit interface [polypeptide binding]; other site 401473005732 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 401473005733 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 401473005734 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 401473005735 beta subunit interaction interface [polypeptide binding]; other site 401473005736 Walker A motif; other site 401473005737 ATP binding site [chemical binding]; other site 401473005738 Walker B motif; other site 401473005739 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 401473005740 F0F1 ATP synthase subunit delta; Provisional; Region: PRK13430 401473005741 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 401473005742 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 401473005743 ATP synthase subunit C; Region: ATP-synt_C; cl00466 401473005744 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 401473005745 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 401473005746 homoserine O-succinyltransferase; Provisional; Region: PRK05368 401473005747 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 401473005748 proposed active site lysine [active] 401473005749 conserved cys residue [active] 401473005750 formyl-coenzyme A transferase; Provisional; Region: PRK05398 401473005751 CoA-transferase family III; Region: CoA_transf_3; pfam02515 401473005752 Membrane transport protein; Region: Mem_trans; cl09117 401473005753 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 401473005754 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 401473005755 PYR/PP interface [polypeptide binding]; other site 401473005756 dimer interface [polypeptide binding]; other site 401473005757 TPP binding site [chemical binding]; other site 401473005758 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 401473005759 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 401473005760 TPP-binding site; other site 401473005761 dimer interface [polypeptide binding]; other site 401473005762 Domain of unknown function (DUF3416); Region: DUF3416; pfam11896 401473005763 Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344 401473005764 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 401473005765 active site 401473005766 homodimer interface [polypeptide binding]; other site 401473005767 catalytic site [active] 401473005768 acceptor binding site [chemical binding]; other site 401473005769 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 401473005770 dimer interface [polypeptide binding]; other site 401473005771 substrate binding site [chemical binding]; other site 401473005772 metal binding sites [ion binding]; metal-binding site 401473005773 Predicted membrane protein [Function unknown]; Region: COG1971 401473005774 Domain of unknown function DUF; Region: DUF204; pfam02659 401473005775 Domain of unknown function DUF; Region: DUF204; pfam02659 401473005776 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 401473005777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 401473005778 DNA binding site [nucleotide binding] 401473005779 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 401473005780 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 401473005781 minor groove reading motif; other site 401473005782 helix-hairpin-helix signature motif; other site 401473005783 substrate binding pocket [chemical binding]; other site 401473005784 active site 401473005785 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 401473005786 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 401473005787 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 401473005788 valyl-tRNA synthetase; Reviewed; Region: valS; PRK13208 401473005789 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401473005790 active site 401473005791 HIGH motif; other site 401473005792 nucleotide binding site [chemical binding]; other site 401473005793 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 401473005794 active site 401473005795 KMSKS motif; other site 401473005796 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 401473005797 tRNA binding surface [nucleotide binding]; other site 401473005798 anticodon binding site; other site 401473005799 chorismate mutase; Provisional; Region: PRK09239 401473005800 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 401473005801 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401473005802 putative DNA binding site [nucleotide binding]; other site 401473005803 putative Zn2+ binding site [ion binding]; other site 401473005804 AsnC family; Region: AsnC_trans_reg; pfam01037 401473005805 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 401473005806 transcription termination factor Rho; Provisional; Region: PRK12608 401473005807 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 401473005808 RNA binding site [nucleotide binding]; other site 401473005809 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 401473005810 Walker A motif; other site 401473005811 ATP binding site [chemical binding]; other site 401473005812 Walker B motif; other site 401473005813 hypothetical protein; Provisional; Region: PRK07208 401473005814 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 401473005815 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 401473005816 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 401473005817 Protein of unknown function (DUF2469); Region: DUF2469; pfam10611 401473005818 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 401473005819 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 401473005820 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 401473005821 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 401473005822 GatB domain; Region: GatB_Yqey; pfam02637 401473005823 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 401473005824 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 401473005825 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 401473005826 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 401473005827 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 401473005828 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 401473005829 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cl00309 401473005830 RmuC family; Region: RmuC; pfam02646 401473005831 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 401473005832 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 401473005833 Clp amino terminal domain; Region: Clp_N; pfam02861 401473005834 Clp amino terminal domain; Region: Clp_N; pfam02861 401473005835 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473005836 Walker A motif; other site 401473005837 ATP binding site [chemical binding]; other site 401473005838 Walker B motif; other site 401473005839 arginine finger; other site 401473005840 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 401473005841 Walker A motif; other site 401473005842 ATP binding site [chemical binding]; other site 401473005843 Walker B motif; other site 401473005844 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 401473005845 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 401473005846 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 401473005847 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 401473005848 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 401473005849 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 401473005850 metal ion-dependent adhesion site (MIDAS); other site 401473005851 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 401473005852 domain interaction interfaces [polypeptide binding]; other site 401473005853 T surface-antigen of pili; Region: FctA; cl16948 401473005854 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 401473005855 active site 401473005856 catalytic site [active] 401473005857 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 401473005858 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 401473005859 catalytic residue [active] 401473005860 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 401473005861 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 401473005862 active site 401473005863 HIGH motif; other site 401473005864 nucleotide binding site [chemical binding]; other site 401473005865 active site 401473005866 KMSKS motif; other site 401473005867 Protein of unknown function (DUF3152); Region: DUF3152; pfam11350 401473005868 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 401473005869 amphipathic channel; other site 401473005870 Asn-Pro-Ala signature motifs; other site 401473005871 Cna protein B-type domain; Region: Cna_B; pfam05738 401473005872 Fibronectin-binding protein signal sequence; Region: Fb_signal; pfam08341 401473005873 TQXA domain; Region: TQXA_dom; TIGR03934 401473005874 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 401473005875 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 401473005876 Walker A/P-loop; other site 401473005877 ATP binding site [chemical binding]; other site 401473005878 Q-loop/lid; other site 401473005879 ABC transporter signature motif; other site 401473005880 Walker B; other site 401473005881 D-loop; other site 401473005882 H-loop/switch region; other site 401473005883 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 401473005884 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473005885 Walker A/P-loop; other site 401473005886 ATP binding site [chemical binding]; other site 401473005887 Q-loop/lid; other site 401473005888 ABC transporter signature motif; other site 401473005889 Walker B; other site 401473005890 D-loop; other site 401473005891 H-loop/switch region; other site 401473005892 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 401473005893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473005894 active site 401473005895 phosphorylation site [posttranslational modification] 401473005896 intermolecular recognition site; other site 401473005897 dimerization interface [polypeptide binding]; other site 401473005898 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 401473005899 DNA binding residues [nucleotide binding] 401473005900 dimerization interface [polypeptide binding]; other site 401473005901 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 401473005902 Histidine kinase; Region: HisKA_3; pfam07730 401473005903 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 401473005904 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 401473005905 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 401473005906 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 401473005907 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 401473005908 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 401473005909 dimer interface [polypeptide binding]; other site 401473005910 ssDNA binding site [nucleotide binding]; other site 401473005911 tetramer (dimer of dimers) interface [polypeptide binding]; other site 401473005912 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 401473005913 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 401473005914 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK03092 401473005915 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 401473005916 active site 401473005917 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 401473005918 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 401473005919 substrate binding site [chemical binding]; other site 401473005920 dimer interface [polypeptide binding]; other site 401473005921 ATP binding site [chemical binding]; other site 401473005922 Major Facilitator Superfamily; Region: MFS_1; pfam07690 401473005923 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 401473005924 active site 401473005925 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473005926 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473005927 DNA binding site [nucleotide binding] 401473005928 domain linker motif; other site 401473005929 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473005930 dimerization interface [polypeptide binding]; other site 401473005931 ligand binding site [chemical binding]; other site 401473005932 Sulfatase; Region: Sulfatase; pfam00884 401473005933 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 401473005934 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 401473005935 active site 401473005936 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 401473005937 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 401473005938 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 401473005939 putative ADP-binding pocket [chemical binding]; other site 401473005940 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 401473005941 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 401473005942 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 401473005943 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 401473005944 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 401473005945 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 401473005946 active site 401473005947 Glycosyl hydrolase family 99-like domain of WbsX-like glycosyltransferases; Region: Glyco_tran_WbsX; cd11579 401473005948 putative ligand binding site [chemical binding]; other site 401473005949 putative catalytic site [active] 401473005950 Protein of unknown function (DUF4012); Region: DUF4012; pfam13196 401473005951 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 401473005952 Bacterial sugar transferase; Region: Bac_transf; pfam02397 401473005953 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 401473005954 Acyltransferase family; Region: Acyl_transf_3; pfam01757 401473005955 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 401473005956 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 401473005957 active site 401473005958 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 401473005959 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 401473005960 active site 401473005961 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 401473005962 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 401473005963 active site 401473005964 Fic family protein [Function unknown]; Region: COG3177 401473005965 Fic/DOC family; Region: Fic; pfam02661 401473005966 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 401473005967 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 401473005968 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 401473005969 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 401473005970 Walker A/P-loop; other site 401473005971 ATP binding site [chemical binding]; other site 401473005972 Q-loop/lid; other site 401473005973 ABC transporter signature motif; other site 401473005974 Walker B; other site 401473005975 D-loop; other site 401473005976 H-loop/switch region; other site 401473005977 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 401473005978 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 401473005979 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 401473005980 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 401473005981 NAD(P) binding site [chemical binding]; other site 401473005982 active site 401473005983 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 401473005984 substrate binding site; other site 401473005985 dimer interface; other site 401473005986 LicD family; Region: LicD; pfam04991 401473005987 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 401473005988 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 401473005989 active site 401473005990 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 401473005991 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 401473005992 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 401473005993 Acyltransferase family; Region: Acyl_transf_3; pfam01757 401473005994 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 401473005995 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 401473005996 active site 401473005997 catalytic triad [active] 401473005998 oxyanion hole [active] 401473005999 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 401473006000 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 401473006001 Ligand binding site; other site 401473006002 Putative Catalytic site; other site 401473006003 DXD motif; other site 401473006004 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 401473006005 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 401473006006 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 401473006007 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 401473006008 active site 401473006009 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 401473006010 Domain of unknown function (DUF303); Region: DUF303; pfam03629 401473006011 Predicted permeases [General function prediction only]; Region: COG0701 401473006012 Domain of unknown function (DUF1980); Region: DUF1980; cl01492 401473006013 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 401473006014 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 401473006015 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 401473006016 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 401473006017 TM-ABC transporter signature motif; other site 401473006018 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 401473006019 Q-loop/lid; other site 401473006020 ABC transporter signature motif; other site 401473006021 Walker B; other site 401473006022 D-loop; other site 401473006023 H-loop/switch region; other site 401473006024 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 401473006025 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 401473006026 ABC-type xylose transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: XylF; COG4213 401473006027 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 401473006028 putative ligand binding site [chemical binding]; other site 401473006029 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 401473006030 putative DNA binding site [nucleotide binding]; other site 401473006031 putative Zn2+ binding site [ion binding]; other site 401473006032 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401473006033 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401473006034 nucleotide binding site [chemical binding]; other site 401473006035 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 401473006036 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 401473006037 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 401473006038 Walker A/P-loop; other site 401473006039 ATP binding site [chemical binding]; other site 401473006040 Q-loop/lid; other site 401473006041 ABC transporter signature motif; other site 401473006042 Walker B; other site 401473006043 D-loop; other site 401473006044 H-loop/switch region; other site 401473006045 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 401473006046 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 401473006047 active site 401473006048 dimer interface [polypeptide binding]; other site 401473006049 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 401473006050 DNA binding residues [nucleotide binding] 401473006051 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 401473006052 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 401473006053 ATP binding site [chemical binding]; other site 401473006054 putative Mg++ binding site [ion binding]; other site 401473006055 helicase superfamily c-terminal domain; Region: HELICc; smart00490 401473006056 ATP-binding site [chemical binding]; other site 401473006057 Predicted helicase [General function prediction only]; Region: COG4889 401473006058 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 401473006059 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 401473006060 FtsX-like permease family; Region: FtsX; pfam02687 401473006061 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 401473006062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473006063 Q-loop/lid; other site 401473006064 ABC transporter signature motif; other site 401473006065 Walker B; other site 401473006066 D-loop; other site 401473006067 H-loop/switch region; other site 401473006068 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 401473006069 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 401473006070 putative active site [active] 401473006071 putative dimer interface [polypeptide binding]; other site 401473006072 K+ potassium transporter; Region: K_trans; pfam02705 401473006073 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 401473006074 active site 401473006075 MFS/sugar transport protein; Region: MFS_2; pfam13347 401473006076 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 401473006077 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 401473006078 alpha-galactosidase; Region: PLN02808; cl17638 401473006079 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473006080 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006081 DNA binding site [nucleotide binding] 401473006082 domain linker motif; other site 401473006083 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473006084 dimerization interface [polypeptide binding]; other site 401473006085 ligand binding site [chemical binding]; other site 401473006086 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 401473006087 active site 401473006088 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310 401473006089 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 401473006090 putative ligand binding site [chemical binding]; other site 401473006091 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 401473006092 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 401473006093 TM-ABC transporter signature motif; other site 401473006094 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 401473006095 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 401473006096 Walker A/P-loop; other site 401473006097 ATP binding site [chemical binding]; other site 401473006098 Q-loop/lid; other site 401473006099 ABC transporter signature motif; other site 401473006100 Walker B; other site 401473006101 D-loop; other site 401473006102 H-loop/switch region; other site 401473006103 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 401473006104 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 401473006105 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473006106 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006107 DNA binding site [nucleotide binding] 401473006108 domain linker motif; other site 401473006109 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473006110 dimerization interface [polypeptide binding]; other site 401473006111 ligand binding site [chemical binding]; other site 401473006112 Melibiase; Region: Melibiase; pfam02065 401473006113 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 401473006114 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 401473006115 Protein of unknown function, DUF624; Region: DUF624; cl02369 401473006116 Glycosyl hydrolase family 43; Region: GH43_6; cd08985 401473006117 active site 401473006118 Glycosyl hydrolase family 43; Region: GH43_2; cd08981 401473006119 active site 401473006120 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006121 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006122 dimer interface [polypeptide binding]; other site 401473006123 ABC-ATPase subunit interface; other site 401473006124 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 401473006125 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006126 dimer interface [polypeptide binding]; other site 401473006127 conserved gate region; other site 401473006128 putative PBP binding loops; other site 401473006129 ABC-ATPase subunit interface; other site 401473006130 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473006131 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473006132 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006133 DNA binding site [nucleotide binding] 401473006134 domain linker motif; other site 401473006135 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473006136 ligand binding site [chemical binding]; other site 401473006137 dimerization interface [polypeptide binding]; other site 401473006138 beta-D-glucuronidase; Provisional; Region: PRK10150 401473006139 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 401473006140 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 401473006141 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 401473006142 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 401473006143 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401473006144 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 401473006145 Walker A/P-loop; other site 401473006146 ATP binding site [chemical binding]; other site 401473006147 Q-loop/lid; other site 401473006148 ABC transporter signature motif; other site 401473006149 Walker B; other site 401473006150 D-loop; other site 401473006151 H-loop/switch region; other site 401473006152 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 401473006153 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 401473006154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 401473006155 Walker A/P-loop; other site 401473006156 ATP binding site [chemical binding]; other site 401473006157 Q-loop/lid; other site 401473006158 ABC transporter signature motif; other site 401473006159 Walker B; other site 401473006160 D-loop; other site 401473006161 H-loop/switch region; other site 401473006162 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 401473006163 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 401473006164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473006165 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 401473006166 putative substrate translocation pore; other site 401473006167 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 401473006168 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 401473006169 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 401473006170 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 401473006171 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 401473006172 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 401473006173 active site 401473006174 HIGH motif; other site 401473006175 KMSKS motif; other site 401473006176 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 401473006177 tRNA binding surface [nucleotide binding]; other site 401473006178 anticodon binding site; other site 401473006179 Predicted methyltransferases [General function prediction only]; Region: COG0313 401473006180 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 401473006181 putative SAM binding site [chemical binding]; other site 401473006182 putative homodimer interface [polypeptide binding]; other site 401473006183 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 401473006184 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 401473006185 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 401473006186 N-terminal domain of cellobiose phosphorylase (CBP) and similar proteins; Region: GH94N_CBP_like; cd11754 401473006187 catalytic domain interface [polypeptide binding]; other site 401473006188 homodimer interface [polypeptide binding]; other site 401473006189 putative active site [active] 401473006190 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 401473006191 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 401473006192 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473006193 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473006194 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 401473006195 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006196 domain linker motif; other site 401473006197 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473006198 ligand binding site [chemical binding]; other site 401473006199 dimerization interface [polypeptide binding]; other site 401473006200 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 401473006201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 401473006202 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 401473006203 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 401473006204 NAD(P) binding site [chemical binding]; other site 401473006205 catalytic residues [active] 401473006206 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 401473006207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006208 dimer interface [polypeptide binding]; other site 401473006209 conserved gate region; other site 401473006210 putative PBP binding loops; other site 401473006211 ABC-ATPase subunit interface; other site 401473006212 potential frameshift: common BLAST hit: gi|118472060|ref|YP_889020.1| ABC transporter permease protein 401473006213 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473006214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473006215 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 401473006216 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 401473006217 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 401473006218 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 401473006219 Walker A/P-loop; other site 401473006220 ATP binding site [chemical binding]; other site 401473006221 Q-loop/lid; other site 401473006222 ABC transporter signature motif; other site 401473006223 Walker B; other site 401473006224 D-loop; other site 401473006225 H-loop/switch region; other site 401473006226 TOBE domain; Region: TOBE_2; pfam08402 401473006227 Transcriptional regulators [Transcription]; Region: FadR; COG2186 401473006228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 401473006229 DNA-binding site [nucleotide binding]; DNA binding site 401473006230 FCD domain; Region: FCD; pfam07729 401473006231 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 401473006232 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 401473006233 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 401473006234 active site 401473006235 NAD binding site [chemical binding]; other site 401473006236 metal binding site [ion binding]; metal-binding site 401473006237 4-aminobutyrate aminotransferase; Provisional; Region: PRK06058 401473006238 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 401473006239 inhibitor-cofactor binding pocket; inhibition site 401473006240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473006241 catalytic residue [active] 401473006242 Purine catabolism regulatory protein-like family; Region: PucR; pfam07905 401473006243 Domain of Unknown Function (DUF1521); Region: DUF1521; pfam07481 401473006244 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 401473006245 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401473006246 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 401473006247 nucleotide binding site [chemical binding]; other site 401473006248 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 401473006249 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 401473006250 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 401473006251 Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000 401473006252 inhibitor binding site; inhibition site 401473006253 active site 401473006254 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 401473006255 Endoglucanase [Carbohydrate transport and metabolism]; Region: BglC; COG2730 401473006256 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 401473006257 Carbohydrate binding domain X2; Region: CBM_X2; pfam03442 401473006258 putative alpha-glucosidase; Provisional; Region: PRK10658 401473006259 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 401473006260 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 401473006261 active site 401473006262 homotrimer interface [polypeptide binding]; other site 401473006263 catalytic site [active] 401473006264 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 401473006265 Probable beta-xylosidase; Provisional; Region: PLN03080 401473006266 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 401473006267 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473006268 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 401473006269 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 401473006270 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 401473006271 active site 401473006272 catalytic triad [active] 401473006273 oxyanion hole [active] 401473006274 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 401473006275 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473006276 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006277 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006278 dimer interface [polypeptide binding]; other site 401473006279 conserved gate region; other site 401473006280 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473006281 ABC-ATPase subunit interface; other site 401473006282 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 401473006283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006284 dimer interface [polypeptide binding]; other site 401473006285 conserved gate region; other site 401473006286 putative PBP binding loops; other site 401473006287 ABC-ATPase subunit interface; other site 401473006288 Protein of unknown function, DUF624; Region: DUF624; cl02369 401473006289 putative alpha-glucosidase; Provisional; Region: PRK10658 401473006290 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 401473006291 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 401473006292 active site 401473006293 homotrimer interface [polypeptide binding]; other site 401473006294 catalytic site [active] 401473006295 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 401473006296 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006297 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006298 dimer interface [polypeptide binding]; other site 401473006299 conserved gate region; other site 401473006300 putative PBP binding loops; other site 401473006301 ABC-ATPase subunit interface; other site 401473006302 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006303 dimer interface [polypeptide binding]; other site 401473006304 conserved gate region; other site 401473006305 putative PBP binding loops; other site 401473006306 ABC-ATPase subunit interface; other site 401473006307 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473006308 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473006309 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473006310 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006311 DNA binding site [nucleotide binding] 401473006312 domain linker motif; other site 401473006313 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473006314 dimerization interface [polypeptide binding]; other site 401473006315 ligand binding site [chemical binding]; other site 401473006316 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 401473006317 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006319 dimer interface [polypeptide binding]; other site 401473006320 conserved gate region; other site 401473006321 putative PBP binding loops; other site 401473006322 ABC-ATPase subunit interface; other site 401473006323 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473006324 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473006325 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006326 DNA binding site [nucleotide binding] 401473006327 domain linker motif; other site 401473006328 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473006329 dimerization interface [polypeptide binding]; other site 401473006330 ligand binding site [chemical binding]; other site 401473006331 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 401473006332 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 401473006333 AAA domain; Region: AAA_14; pfam13173 401473006334 Domain of unknown function (DUF4143); Region: DUF4143; pfam13635 401473006335 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473006336 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006337 DNA binding site [nucleotide binding] 401473006338 domain linker motif; other site 401473006339 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 401473006340 dimerization interface [polypeptide binding]; other site 401473006341 ligand binding site [chemical binding]; other site 401473006342 sodium binding site [ion binding]; other site 401473006343 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 401473006344 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 401473006345 substrate binding [chemical binding]; other site 401473006346 active site 401473006347 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 401473006348 Protein of unknown function (DUF2961); Region: DUF2961; pfam11175 401473006349 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006350 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006351 dimer interface [polypeptide binding]; other site 401473006352 conserved gate region; other site 401473006353 putative PBP binding loops; other site 401473006354 ABC-ATPase subunit interface; other site 401473006355 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006356 putative PBP binding loops; other site 401473006357 dimer interface [polypeptide binding]; other site 401473006358 ABC-ATPase subunit interface; other site 401473006359 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473006360 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473006361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473006362 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 401473006363 motif I; other site 401473006364 active site 401473006365 Helix-Turn-Helix DNA binding domain of the HspR transcription regulator; Region: HTH_HspR; cd04766 401473006366 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 401473006367 DNA binding residues [nucleotide binding] 401473006368 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 401473006369 HSP70 interaction site [polypeptide binding]; other site 401473006370 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 401473006371 substrate binding site [polypeptide binding]; other site 401473006372 dimer interface [polypeptide binding]; other site 401473006373 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cl03075 401473006374 GrpE; Region: GrpE; pfam01025 401473006375 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 401473006376 dimer interface [polypeptide binding]; other site 401473006377 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 401473006378 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 401473006379 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 401473006380 nucleotide binding site [chemical binding]; other site 401473006381 alkaline phosphatase; Provisional; Region: PRK10518 401473006382 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 401473006383 active site 401473006384 dimer interface [polypeptide binding]; other site 401473006385 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 401473006386 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 401473006387 putative active site [active] 401473006388 putative catalytic site [active] 401473006389 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006390 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006391 dimer interface [polypeptide binding]; other site 401473006392 conserved gate region; other site 401473006393 putative PBP binding loops; other site 401473006394 ABC-ATPase subunit interface; other site 401473006395 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006396 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006397 dimer interface [polypeptide binding]; other site 401473006398 conserved gate region; other site 401473006399 putative PBP binding loops; other site 401473006400 ABC-ATPase subunit interface; other site 401473006401 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 401473006402 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473006403 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473006404 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006405 DNA binding site [nucleotide binding] 401473006406 domain linker motif; other site 401473006407 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473006408 ligand binding site [chemical binding]; other site 401473006409 dimerization interface [polypeptide binding]; other site 401473006410 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 401473006411 Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827 401473006412 active site 401473006413 catalytic site [active] 401473006414 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 401473006415 domain interaction interfaces [polypeptide binding]; other site 401473006416 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 401473006417 choice-of-anchor A domain; Region: choice_anch_A; TIGR04215 401473006418 Bacterial Ig-like domain (group 2); Region: Big_2; cl02708 401473006419 Cna protein B-type domain; Region: Cna_B; pfam05738 401473006420 Cna protein B-type domain; Region: Cna_B; pfam05738 401473006421 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473006422 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006423 DNA binding site [nucleotide binding] 401473006424 domain linker motif; other site 401473006425 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473006426 ligand binding site [chemical binding]; other site 401473006427 dimerization interface [polypeptide binding]; other site 401473006428 TraX protein; Region: TraX; cl05434 401473006429 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 401473006430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 401473006431 motif II; other site 401473006432 pullulanase, type I; Region: pulA_typeI; TIGR02104 401473006433 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 401473006434 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 401473006435 Ca binding site [ion binding]; other site 401473006436 active site 401473006437 catalytic site [active] 401473006438 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006440 dimer interface [polypeptide binding]; other site 401473006441 conserved gate region; other site 401473006442 ABC-ATPase subunit interface; other site 401473006443 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 401473006444 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006445 dimer interface [polypeptide binding]; other site 401473006446 conserved gate region; other site 401473006447 putative PBP binding loops; other site 401473006448 ABC-ATPase subunit interface; other site 401473006449 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 401473006450 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 401473006451 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 401473006452 active site 401473006453 catalytic site [active] 401473006454 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 401473006455 4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640 401473006456 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), trehalose synthase (also called maltose alpha-D-glucosyltransferase), and related proteins; Region: AmyAc_OligoGlu_TS; cd11332 401473006457 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 401473006458 active site 401473006459 catalytic site [active] 401473006460 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 401473006461 Protein of unknown function, DUF624; Region: DUF624; pfam04854 401473006462 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006464 dimer interface [polypeptide binding]; other site 401473006465 conserved gate region; other site 401473006466 putative PBP binding loops; other site 401473006467 ABC-ATPase subunit interface; other site 401473006468 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006469 dimer interface [polypeptide binding]; other site 401473006470 conserved gate region; other site 401473006471 putative PBP binding loops; other site 401473006472 ABC-ATPase subunit interface; other site 401473006473 Transcriptional regulators [Transcription]; Region: PurR; COG1609 401473006474 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 401473006475 DNA binding site [nucleotide binding] 401473006476 domain linker motif; other site 401473006477 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 401473006478 ligand binding site [chemical binding]; other site 401473006479 dimerization interface [polypeptide binding]; other site 401473006480 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 401473006481 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473006482 catalytic core [active] 401473006483 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 401473006484 Protein of unknown function (DUF4235); Region: DUF4235; pfam14019 401473006485 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 401473006486 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 401473006487 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 401473006488 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473006489 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 401473006490 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473006491 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 401473006492 active site 401473006493 phosphorylation site [posttranslational modification] 401473006494 intermolecular recognition site; other site 401473006495 dimerization interface [polypeptide binding]; other site 401473006496 LytTr DNA-binding domain; Region: LytTR; pfam04397 401473006497 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473006498 ATP binding site [chemical binding]; other site 401473006499 Mg2+ binding site [ion binding]; other site 401473006500 G-X-G motif; other site 401473006501 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 401473006502 dimer interface [polypeptide binding]; other site 401473006503 FMN binding site [chemical binding]; other site 401473006504 NADPH bind site [chemical binding]; other site 401473006505 NAD-dependent protein deacetylases, SIR2 family [Transcription]; Region: SIR2; COG0846 401473006506 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 401473006507 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 401473006508 tetramer interface [polypeptide binding]; other site 401473006509 threonine dehydratase; Provisional; Region: PRK08198 401473006510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473006511 catalytic residue [active] 401473006512 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 401473006513 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 401473006514 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 401473006515 Ca binding site [ion binding]; other site 401473006516 active site 401473006517 catalytic site [active] 401473006518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 401473006519 ABC-ATPase subunit interface; other site 401473006520 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 401473006521 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006522 dimer interface [polypeptide binding]; other site 401473006523 conserved gate region; other site 401473006524 putative PBP binding loops; other site 401473006525 ABC-ATPase subunit interface; other site 401473006526 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 401473006527 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006528 dimer interface [polypeptide binding]; other site 401473006529 conserved gate region; other site 401473006530 putative PBP binding loops; other site 401473006531 ABC-ATPase subunit interface; other site 401473006532 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 401473006533 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 401473006534 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 401473006535 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 401473006536 Melibiase; Region: Melibiase; pfam02065 401473006537 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 401473006538 nucleoside/Zn binding site; other site 401473006539 dimer interface [polypeptide binding]; other site 401473006540 catalytic motif [active] 401473006541 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 401473006542 Predicted esterase [General function prediction only]; Region: COG0400 401473006543 Serine hydrolase (FSH1); Region: FSH1; pfam03959 401473006544 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 401473006545 trimer interface [polypeptide binding]; other site 401473006546 active site 401473006547 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 401473006548 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 401473006549 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 401473006550 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 401473006551 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 401473006552 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 401473006553 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 401473006554 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 401473006555 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 401473006556 Lipopolysaccharide kinase (Kdo/WaaP) family; Region: Kdo; cl17488 401473006557 Domain of unknown function (DUF4032); Region: DUF4032; pfam13224 401473006558 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 401473006559 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 401473006560 Walker A/P-loop; other site 401473006561 ATP binding site [chemical binding]; other site 401473006562 Q-loop/lid; other site 401473006563 ABC transporter signature motif; other site 401473006564 Walker B; other site 401473006565 D-loop; other site 401473006566 H-loop/switch region; other site 401473006567 TOBE domain; Region: TOBE_2; pfam08402 401473006568 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 401473006569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 401473006570 active site 401473006571 phosphorylation site [posttranslational modification] 401473006572 intermolecular recognition site; other site 401473006573 dimerization interface [polypeptide binding]; other site 401473006574 LytTr DNA-binding domain; Region: LytTR; smart00850 401473006575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 401473006576 ATP binding site [chemical binding]; other site 401473006577 Mg2+ binding site [ion binding]; other site 401473006578 G-X-G motif; other site 401473006579 Putative ClC chloride channel. Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033 401473006580 putative ion selectivity filter; other site 401473006581 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 401473006582 putative pore gating glutamate residue; other site 401473006583 Protein of unknown function (DUF3225); Region: DUF3225; pfam11533 401473006584 Amidase; Region: Amidase; cl11426 401473006585 indole-3-acetamide amidohydrolase; Region: PLN02722 401473006586 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 401473006587 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 401473006588 Walker A/P-loop; other site 401473006589 ATP binding site [chemical binding]; other site 401473006590 Q-loop/lid; other site 401473006591 ABC transporter signature motif; other site 401473006592 Walker B; other site 401473006593 D-loop; other site 401473006594 H-loop/switch region; other site 401473006595 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 401473006596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 401473006597 dimer interface [polypeptide binding]; other site 401473006598 conserved gate region; other site 401473006599 ABC-ATPase subunit interface; other site 401473006600 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 401473006601 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 401473006602 substrate binding pocket [chemical binding]; other site 401473006603 membrane-bound complex binding site; other site 401473006604 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 401473006605 Transcriptional regulators [Transcription]; Region: FadR; COG2186 401473006606 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 401473006607 DNA-binding site [nucleotide binding]; DNA binding site 401473006608 FCD domain; Region: FCD; pfam07729 401473006609 maltose O-acetyltransferase; Provisional; Region: PRK10092 401473006610 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 401473006611 active site 401473006612 substrate binding site [chemical binding]; other site 401473006613 trimer interface [polypeptide binding]; other site 401473006614 CoA binding site [chemical binding]; other site 401473006615 aspartate aminotransferase; Provisional; Region: PRK05764 401473006616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 401473006617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 401473006618 homodimer interface [polypeptide binding]; other site 401473006619 catalytic residue [active] 401473006620 AAA ATPase domain; Region: AAA_16; pfam13191 401473006621 Archaeal ATPase; Region: Arch_ATPase; pfam01637 401473006622 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 401473006623 Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008 401473006624 Probable beta-xylosidase; Provisional; Region: PLN03080 401473006625 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 401473006626 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473006627 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 401473006628 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473006629 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 401473006630 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 401473006631 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 401473006632 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 401473006633 active site 401473006634 Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915 401473006635 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 401473006636 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 401473006637 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 401473006638 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 401473006639 Catalytic domain of Protein Kinases; Region: PKc; cd00180 401473006640 active site 401473006641 ATP binding site [chemical binding]; other site 401473006642 substrate binding site [chemical binding]; other site 401473006643 activation loop (A-loop); other site 401473006644 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 401473006645 DsbA family; consists of DsbA and DsbA-like proteins, including DsbC, DsbG, glutathione (GSH) S-transferase kappa (GSTK), 2-hydroxychromene-2-carboxylate (HCCA) isomerase, an oxidoreductase (FrnE) presumed to be involved in frenolicin biosynthesis, a...; Region: DsbA_family; cd02972 401473006646 catalytic residues [active] 401473006647 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 401473006648 Domain of unknown function (DUF348); Region: DUF348; pfam03990 401473006649 G5 domain; Region: G5; pfam07501 401473006650 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 401473006651 N-acetyl-D-glucosamine binding site [chemical binding]; other site 401473006652 catalytic residue [active] 401473006653 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 401473006654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 401473006655 S-adenosylmethionine binding site [chemical binding]; other site 401473006656 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 401473006657 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 401473006658 LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399 401473006659 tRNA adenylyltransferase; Region: tRNA_CCA_actino; TIGR02692 401473006660 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 401473006661 active site 401473006662 NTP binding site [chemical binding]; other site 401473006663 metal binding triad [ion binding]; metal-binding site 401473006664 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 401473006665 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 401473006666 Zn2+ binding site [ion binding]; other site 401473006667 Mg2+ binding site [ion binding]; other site 401473006668 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 401473006669 Diadenosine hexaphosphate (Ap6A) hydrolase is a member of the Nudix hydrolase superfamily. Ap6A hydrolase specifically hydrolyzes diadenosine polyphosphates, but not ATP or diadenosine triphosphate, and it generates ATP as the product. Ap6A, the most...; Region: Ap6A_hydrolase; cd03673 401473006670 active site 401473006671 Ap6A binding site [chemical binding]; other site 401473006672 nudix motif; other site 401473006673 metal binding site [ion binding]; metal-binding site 401473006674 integral membrane protein MviN; Region: mviN; TIGR01695 401473006675 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 401473006676 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 401473006677 acetolactate synthase; Reviewed; Region: PRK08322 401473006678 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 401473006679 PYR/PP interface [polypeptide binding]; other site 401473006680 dimer interface [polypeptide binding]; other site 401473006681 TPP binding site [chemical binding]; other site 401473006682 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 401473006683 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 401473006684 TPP-binding site [chemical binding]; other site 401473006685 dimer interface [polypeptide binding]; other site 401473006686 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 401473006687 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 401473006688 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 401473006689 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 401473006690 ParB-like nuclease domain; Region: ParB; smart00470 401473006691 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 401473006692 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 401473006693 P-loop; other site 401473006694 Magnesium ion binding site [ion binding]; other site 401473006695 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 401473006696 Magnesium ion binding site [ion binding]; other site 401473006697 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 401473006698 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 401473006699 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 401473006700 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 401473006701 G-X-X-G motif; other site 401473006702 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 401473006703 RxxxH motif; other site 401473006704 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 401473006705 Ribonuclease P; Region: Ribonuclease_P; pfam00825 401473006706 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399